<110> Hyseq, Inc.


<120>  Novel Nucleic Acids and Polypeptides

<130>  21272-041

<140>  Not yet assigned

<141>  2001-02-26

<150>  09/664,641

<151>  2000-09-19

<150>  09/616,807
<151>  2000-07-14

<150>  09/597,707
<151>  2000-06-17

<150>  09/577,409

<151>  2000-05-18

<150>  09/515,126
<151>  2000-02-28

<160>  688    



<170>  Custom



      <210> 1
      <211> 1049
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(727)

      <400> 1
 tcactaggcc agtgacgtgg aaatcgcgct taggggctga ggcgcg   atg gca ggt      55
                                                      Met Ala Gly
                                                        1

 gtc ggg gct ggg cct ctg cgg gcg atg ggg cgg cag gcc ctg ctg ctt      103
 Val Gly Ala Gly Pro Leu Arg Ala Met Gly Arg Gln Ala Leu Leu Leu
       5                  10                  15

 ctc gcg ctg tgc gcc aca ggc gcc cag ggg ctc tac ttc cac atc ggc      151
 Leu Ala Leu Cys Ala Thr Gly Ala Gln Gly Leu Tyr Phe His Ile Gly
  20                  25                  30                  35

 gag acc gag aag cgc tgt ttc atc gag gaa atc ccc gac gag acc atg      199
 Glu Thr Glu Lys Arg Cys Phe Ile Glu Glu Ile Pro Asp Glu Thr Met
                  40                  45                  50

 gtc atc ggc aac tat cgt acc cag atg tgg gat aag cag aag gag gtc      247
 Val Ile Gly Asn Tyr Arg Thr Gln Met Trp Asp Lys Gln Lys Glu Val
              55                  60                  65

 ttc ctg ccc tcg acc cct ggc ctg ggc atg cac gtg gaa gtg aag gac      295
 Phe Leu Pro Ser Thr Pro Gly Leu Gly Met His Val Glu Val Lys Asp
          70                  75                  80

 ccc gac ggc aag gtg gtg ctg tcc cgg cag tac ggc tcg gag ggc cgc      343
 Pro Asp Gly Lys Val Val Leu Ser Arg Gln Tyr Gly Ser Glu Gly Arg
      85                  90                  95

 ttc acg ttc acc tcc cac acg ccc ggt gac cat caa atc tgt ctg cac      391
 Phe Thr Phe Thr Ser His Thr Pro Gly Asp His Gln Ile Cys Leu His
 100                 105                 110                 115

 tcc aat tct acc agg atg gct ctc ttc gct ggt ggc aaa ctg cgt gtg      439
 Ser Asn Ser Thr Arg Met Ala Leu Phe Ala Gly Gly Lys Leu Arg Val
                 120                 125                 130

 cat ctc gac atc cag gtt ggg gag cat gcc aac aac tac cct gag att      487
 His Leu Asp Ile Gln Val Gly Glu His Ala Asn Asn Tyr Pro Glu Ile
             135                 140                 145

 gct gca aaa gat aag ctg acg gag cta cag ctc cgc gcc cgc cag ttg      535
 Ala Ala Lys Asp Lys Leu Thr Glu Leu Gln Leu Arg Ala Arg Gln Leu
         150                 155                 160

 ctt gat cag gtg gaa cag att cag aag gag cag gat tac caa agg tat      583
 Leu Asp Gln Val Glu Gln Ile Gln Lys Glu Gln Asp Tyr Gln Arg Tyr
     165                 170                 175

 cgt gaa gag cgc ttc cga ctg acg agc gag agc acc aac cag agg gtc      631
 Arg Glu Glu Arg Phe Arg Leu Thr Ser Glu Ser Thr Asn Gln Arg Val
 180                 185                 190                 195

 cta tgg tgg tcc att gct cag act gtc atc ctc atc ctc act ggc atc      679
 Leu Trp Trp Ser Ile Ala Gln Thr Val Ile Leu Ile Leu Thr Gly Ile
                 200                 205                 210

 tgg cag atg cgt cac ctc aag agc ttc ttt gag gcc aag aag ctg gtg      727
 Trp Gln Met Arg His Leu Lys Ser Phe Phe Glu Ala Lys Lys Leu Val 
             215                 220                 225

 tagtgccctc tttgtatgac ccttcctttt tacctcattt atttggtact ttccccacac    787

 agtcctttat ccacctggat ttttagggaa aaaaatgaaa aagaataagt cacattggtt    847

 ccatggccac aaaccattca gatcagccac ttgctgaccc tggttcttaa ggacacatga    907

 cattagtcca atctttcaaa atcttgtctt agggcttgtg aggaatcaga actaacccag    967

 gactcagtcc tgcttctttt gcctcgagtg attttcctct gtttttcact aaataagcaa   1027

 atgaaaactc aaaaaaaaaa aa                                            1049




      <210> 2
      <211> 2582
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1569)

      <400> 2
  atg gtg gca gga gag agt gag aag ggg gag gcc cag gag cta tta aaa      48
  Met Val Ala Gly Glu Ser Glu Lys Gly Glu Ala Gln Glu Leu Leu Lys
    1               5                  10                  15

 acc aga ctg aac caa ggg tca ggt ccc aca ctg ggc acc caa gct gcc       96
 Thr Arg Leu Asn Gln Gly Ser Gly Pro Thr Leu Gly Thr Gln Ala Ala
              20                  25                  30

 att ttt aag act gcc atg cca ctg aac cac aga gaa gac agg agc caa      144
 Ile Phe Lys Thr Ala Met Pro Leu Asn His Arg Glu Asp Arg Ser Gln
          35                  40                  45

 gag gct ata atc acg tgc tcc gaa gac ttc cgg gtt tcc aac gtg act      192
 Glu Ala Ile Ile Thr Cys Ser Glu Asp Phe Arg Val Ser Asn Val Thr
      50                  55                  60

 tcc ggt tgt cag aat tta ccc ctg acg cgg cgg cgg ccg acg gga agc      240
 Ser Gly Cys Gln Asn Leu Pro Leu Thr Arg Arg Arg Pro Thr Gly Ser
  65                  70                  75                  80

 tgt gtg tgc tta ggt cgt ggt ggc ccc ggt ggt ggt ggg ctc cgg gcg      288
 Cys Val Cys Leu Gly Arg Gly Gly Pro Gly Gly Gly Gly Leu Arg Ala
                  85                  90                  95

 ggc tcg cgt cat cct gcc ccc gct gcg atg cat ccg cgg cgc ccg gac      336
 Gly Ser Arg His Pro Ala Pro Ala Ala Met His Pro Arg Arg Pro Asp
             100                 105                 110

 gga ttt gat ggc ttg ggc tac cgg ggt ggt gcc cgg gac gag cag ggc      384
 Gly Phe Asp Gly Leu Gly Tyr Arg Gly Gly Ala Arg Asp Glu Gln Gly
         115                 120                 125

 ttt ggc ggc gcc ttc cct gca agg tcc ttc agc acc ggg tcg gac ctg      432
 Phe Gly Gly Ala Phe Pro Ala Arg Ser Phe Ser Thr Gly Ser Asp Leu
     130                 135                 140

 ggc cac tgg gtg acg act ccc cca gat atc ccc ggc agc cgc aac ctg      480
 Gly His Trp Val Thr Thr Pro Pro Asp Ile Pro Gly Ser Arg Asn Leu
 145                 150                 155                 160

 cac tgg ggc gag aag agc ccg ccc tac ggc gtg ccc acc acc tcc acc      528
 His Trp Gly Glu Lys Ser Pro Pro Tyr Gly Val Pro Thr Thr Ser Thr
                 165                 170                 175

 ccg tac gaa ggc ccc acg gag gaa ccc ttt tcc agt ggc ggc ggc ggc      576
 Pro Tyr Glu Gly Pro Thr Glu Glu Pro Phe Ser Ser Gly Gly Gly Gly
             180                 185                 190

 agt gtg cag ggg cag agc agt gaa cag ctg aat aga ttt gct gga ttt      624
 Ser Val Gln Gly Gln Ser Ser Glu Gln Leu Asn Arg Phe Ala Gly Phe
         195                 200                 205

 ggt att gga ctt gca agt ctc ttt aca gaa aat gta ttg gca cat cct      672
 Gly Ile Gly Leu Ala Ser Leu Phe Thr Glu Asn Val Leu Ala His Pro
     210                 215                 220

 tgc att gtt cta cgc cgc caa tgt cag gtt aat tac cat gct cag cat      720
 Cys Ile Val Leu Arg Arg Gln Cys Gln Val Asn Tyr His Ala Gln His
 225                 230                 235                 240

 tac cat ctc act cca ttt aca gtc atc aat att atg tac agt ttc aac      768
 Tyr His Leu Thr Pro Phe Thr Val Ile Asn Ile Met Tyr Ser Phe Asn
                 245                 250                 255

 aaa act cag gga cct aga gcc ctg tgg aaa gga atg gga agt aca ttt      816
 Lys Thr Gln Gly Pro Arg Ala Leu Trp Lys Gly Met Gly Ser Thr Phe
             260                 265                 270

 att gtc cag gga gtc aca ctt gga gca gaa ggc ata att agt gaa ttt      864
 Ile Val Gln Gly Val Thr Leu Gly Ala Glu Gly Ile Ile Ser Glu Phe
         275                 280                 285

 aca cct ttg cca agg gag gtt tta cat aaa tgg agt cct aaa caa ata      912
 Thr Pro Leu Pro Arg Glu Val Leu His Lys Trp Ser Pro Lys Gln Ile
     290                 295                 300

 gga gaa cac ctt cta ctg aaa tcc cta act tac gtg gtg gca atg cct      960
 Gly Glu His Leu Leu Leu Lys Ser Leu Thr Tyr Val Val Ala Met Pro
 305                 310                 315                 320

 ttt tat tca gca agt ctg att gaa aca gtg cag agt gag ata att cga     1008
 Phe Tyr Ser Ala Ser Leu Ile Glu Thr Val Gln Ser Glu Ile Ile Arg
                 325                 330                 335

 gat aat act ggc att ttg gag tgt gtt aaa gaa gga att gga aga gtg     1056
 Asp Asn Thr Gly Ile Leu Glu Cys Val Lys Glu Gly Ile Gly Arg Val
             340                 345                 350

 ata ggc atg gga gtg cct cat agc aaa cga ctt ctt ccg ctt ctt tcc     1104
 Ile Gly Met Gly Val Pro His Ser Lys Arg Leu Leu Pro Leu Leu Ser
         355                 360                 365

 ttg atc ttc cct acg gtg ctt cat gga gtt ctt cat tac atc atc agc     1152
 Leu Ile Phe Pro Thr Val Leu His Gly Val Leu His Tyr Ile Ile Ser
     370                 375                 380

 tca gtt att cag aag ttt gtc cta cta att cta aag aga aag act tac     1200
 Ser Val Ile Gln Lys Phe Val Leu Leu Ile Leu Lys Arg Lys Thr Tyr
 385                 390                 395                 400

 aat agc cac cta gct gag agc act agc cct gtg cag agt atg ttg gat     1248
 Asn Ser His Leu Ala Glu Ser Thr Ser Pro Val Gln Ser Met Leu Asp
                 405                 410                 415

 gct tat ttt cca gaa ctt att gct aac ttt gct gcc agt ctt tgt tct     1296
 Ala Tyr Phe Pro Glu Leu Ile Ala Asn Phe Ala Ala Ser Leu Cys Ser
             420                 425                 430

 gac gtt ata ctt tac cca ttg gaa aca gtt ttg cac cgc ctt cac att     1344
 Asp Val Ile Leu Tyr Pro Leu Glu Thr Val Leu His Arg Leu His Ile
         435                 440                 445

 caa gga aca cgc aca ata att gac aat aca gac ctt ggc tat gaa gtg     1392
 Gln Gly Thr Arg Thr Ile Ile Asp Asn Thr Asp Leu Gly Tyr Glu Val
     450                 455                 460

 ctt cca att aat aca caa tat gag gga atg aga gac tgt atc aat acc     1440
 Leu Pro Ile Asn Thr Gln Tyr Glu Gly Met Arg Asp Cys Ile Asn Thr
 465                 470                 475                 480

 ata agg cag gag gaa gga gtg ttt ggt ttt tat aaa ggg ttt ggt gct     1488
 Ile Arg Gln Glu Glu Gly Val Phe Gly Phe Tyr Lys Gly Phe Gly Ala
                 485                 490                 495

 gtt ata ata cag tac aca ctg cat gca gct gtt tta cag att acc aaa     1536
 Val Ile Ile Gln Tyr Thr Leu His Ala Ala Val Leu Gln Ile Thr Lys
             500                 505                 510

 att att tac tct aca ctt ctt caa aat aac att tgagattt aggttccttc     1587
 Ile Ile Tyr Ser Thr Leu Leu Gln Asn Asn Ile 
         515                 520

 actgagtagt ctggaagata taatctggat aatttgctat gaagttatga gggataaaag   1647

 tgaaatactg gggaagaaaa tggattggaa agtaaaattg gtactaaagc ccatactgat   1707

 tatcttgact ttgtttttta aggcataggt atatattttg gatcaaaatc cttccaaatt   1767

 tgaaaactca ataaaaataa cacttattaa attctagtta gtgtagcact catgctgaag   1827

 taaacatgat cgtaggcaga agcaaaattt tattataaaa tctaaaacaa aactttatag   1887

 agttgaatct attccatctg acttcaatat ttgccaaacg tttattttac ctcctagatt   1947

 gatgttggta tagtatcctt aatacagtgt agtatattaa tgtccttaat acaatcagga   2007

 ggtttttacc tttaagcaaa taaattatgt cattattgaa aaagacttaa gggatgatta   2067

 gacttggcaa tctgtaagca ggagtataaa tgttttaaat tgcattgtcc ctatgtaact   2127

 atcttaatgg ctatatatat gtattttata aagccattta tgtatacaca tgtaacttgg   2187

 aatttccttc atccctacac attttctaca cttacatcac cttattgcat aaaacaaagt   2247

 cacgcgcttt ctgcttgaac atcaaaatat caaaaaccaa ggtacccaaa agatacaagt   2307

 cagagacaac atccttgtcc atatccaaac ccagtgtttc agtgctagca acttaatttc   2367

 tcatacattt atagagtttg gtttgctttg ctagttgtgt gaatcattgg gctgttttta   2427

 gagccactgt taagagagaa tataaaataa tcatgacaat tactactgtt tccacattta   2487

 caaattgtgt acttaaatga acctcatttc ccttttattt ctgaatggct tgtctgagag   2547

 gaaacaaaat taaaattcat ctgggaaaaa aaaaa                              2582




      <210> 3
      <211> 3232
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (216)..(1655)

      <400> 3
 ggcacgagcc cggctctggc gtccctggct gccaagcctg aggcccgcag tcctactccc     60

 gccgagaccc gccgctccgg tcctgccccg aactgcccac ggccggcagc gcttccaggc    120

 cctgaaaaaa actctcttcc tgtgtctggc cagaggtata gagagagaca ggttcaactc    180

 taaggcctga aaaggaacaa ggcccaccgg aagca   atg gcc act gtc cct ggc     233
                                          Met Ala Thr Val Pro Gly
                                            1               5

 ctc cag ccc ctg cca acc ttg gag cag gac ctg gaa cag gaa gag atc      281
 Leu Gln Pro Leu Pro Thr Leu Glu Gln Asp Leu Glu Gln Glu Glu Ile
              10                  15                  20

 ctg att gtg aag gtg gag gag gac ttc tgc ttg gaa gag gag ccc tcc      329
 Leu Ile Val Lys Val Glu Glu Asp Phe Cys Leu Glu Glu Glu Pro Ser
          25                  30                  35

 gtg gag acg gag gac ccc agc cct gag act ttc cgc cag ctc ttc cgg      377
 Val Glu Thr Glu Asp Pro Ser Pro Glu Thr Phe Arg Gln Leu Phe Arg
      40                  45                  50

 ctc ttc tgc tac cag gag gtg gct ggg ccc cgg gag gcc ctg agc cgc      425
 Leu Phe Cys Tyr Gln Glu Val Ala Gly Pro Arg Glu Ala Leu Ser Arg
  55                  60                  65                  70

 ctc tgg gag ctg tgc tgc cgc tgg ctg cgg ccg gag ctg cgc acc aag      473
 Leu Trp Glu Leu Cys Cys Arg Trp Leu Arg Pro Glu Leu Arg Thr Lys
                  75                  80                  85

 gag cag atc ctg gag ctg ctg gtg ctg gag cag ttc ctg act gtg ctg      521
 Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Thr Val Leu
              90                  95                 100

 ccg ggg gag atc cag gct cgg gta cgc gag cag cag ccg gag agc ggt      569
 Pro Gly Glu Ile Gln Ala Arg Val Arg Glu Gln Gln Pro Glu Ser Gly
         105                 110                 115

 gag gag gcc gtg gtc ctc gtg gaa ggg ctg cag cgg aag ccc agg aaa      617
 Glu Glu Ala Val Val Leu Val Glu Gly Leu Gln Arg Lys Pro Arg Lys
     120                 125                 130

 cac agg cag cgg ggc tca gag ctg ctt tct gat gac gag gtg ccc ctc      665
 His Arg Gln Arg Gly Ser Glu Leu Leu Ser Asp Asp Glu Val Pro Leu
 135                 140                 145                 150

 ggg ata ggg gga cag ttc tta aaa cac cag gca gag gct cag cca gag      713
 Gly Ile Gly Gly Gln Phe Leu Lys His Gln Ala Glu Ala Gln Pro Glu
                 155                 160                 165

 gat ctg tcc ctg gag gaa gag gct cga ttc tcc agc cag cag ccc cca      761
 Asp Leu Ser Leu Glu Glu Glu Ala Arg Phe Ser Ser Gln Gln Pro Pro
             170                 175                 180

 gcc cag ctg agc cac agg cca cag agg ggc ccg ctg ttg tgg cca gag      809
 Ala Gln Leu Ser His Arg Pro Gln Arg Gly Pro Leu Leu Trp Pro Glu
         185                 190                 195

 aga ggc cct cca gct ccc cgg cat cag gag atg gcg tca gcc tcg ccc      857
 Arg Gly Pro Pro Ala Pro Arg His Gln Glu Met Ala Ser Ala Ser Pro
     200                 205                 210

 ttc ctt tcg gcc tgg tcc cag gtg ccc gtg aac ttg gag gac gtg gct      905
 Phe Leu Ser Ala Trp Ser Gln Val Pro Val Asn Leu Glu Asp Val Ala
 215                 220                 225                 230

 gta tac ctt tct ggg gag gag cca aga tgc atg gac cca gct cag cgg      953
 Val Tyr Leu Ser Gly Glu Glu Pro Arg Cys Met Asp Pro Ala Gln Arg
                 235                 240                 245

 gac gcg ccg ctg gag aat gaa gga cct ggg atc cag ttg gag gac ggc     1001
 Asp Ala Pro Leu Glu Asn Glu Gly Pro Gly Ile Gln Leu Glu Asp Gly
             250                 255                 260

 ggt gat ggc agg gag gat gcc ccg ttg aga atg gag tgg tac cga gtg     1049
 Gly Asp Gly Arg Glu Asp Ala Pro Leu Arg Met Glu Trp Tyr Arg Val
         265                 270                 275

 ctc tcg gca cga tgc cag ggg cct ggc cac ccg ctc cca ggt cag agg     1097
 Leu Ser Ala Arg Cys Gln Gly Pro Gly His Pro Leu Pro Gly Gln Arg
     280                 285                 290

 cca gcc cca gtc agg ggc ttg gtc agg cct gat cag cca aga ggc ggc     1145
 Pro Ala Pro Val Arg Gly Leu Val Arg Pro Asp Gln Pro Arg Gly Gly
 295                 300                 305                 310

 ccc cca cca gga aga cgg gct tcc cat ggg gct gac aag ccg tac acc     1193
 Pro Pro Pro Gly Arg Arg Ala Ser His Gly Ala Asp Lys Pro Tyr Thr
                 315                 320                 325

 tgc ccc gaa tgt ggc aaa ggc ttc agc aag acg tcc cac ttg acc aag     1241
 Cys Pro Glu Cys Gly Lys Gly Phe Ser Lys Thr Ser His Leu Thr Lys
             330                 335                 340

 cac cag cgc aca cac acg ggc gag cgg cct tac aag tgc cta gtc tgt     1289
 His Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Leu Val Cys
         345                 350                 355

 ggg aag ggc ttt agc gac cgc tcc aac ttc agc acg cac cag agg gtg     1337
 Gly Lys Gly Phe Ser Asp Arg Ser Asn Phe Ser Thr His Gln Arg Val
     360                 365                 370

 cac aca ggc gag aag ccc tac ccg tgc ccc gag tgt ggg aag cgc ttc     1385
 His Thr Gly Glu Lys Pro Tyr Pro Cys Pro Glu Cys Gly Lys Arg Phe
 375                 380                 385                 390

 agc cag agc tcc agc ctg gtc atc cac cgc agg aca cac agc ggg gag     1433
 Ser Gln Ser Ser Ser Leu Val Ile His Arg Arg Thr His Ser Gly Glu
                 395                 400                 405

 cgg ccc tat gcc tgc acc cag tgc ggg aag cgc ttc aac aac agc tcg     1481
 Arg Pro Tyr Ala Cys Thr Gln Cys Gly Lys Arg Phe Asn Asn Ser Ser
             410                 415                 420

 cac ttc agc gcc cac cgc cgg acg cac aca ggt gag aag ccc tac acc     1529
 His Phe Ser Ala His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Thr
         425                 430                 435

 tgc ccg gcc tgt ggc cgg ggc ttc cgc cgg ggc acc gac ctg cac aag     1577
 Cys Pro Ala Cys Gly Arg Gly Phe Arg Arg Gly Thr Asp Leu His Lys
     440                 445                 450

 cac cag cgg acc cac atg ggg gca ggc tcc ttg ccg acg ctc cag ccg     1625
 His Gln Arg Thr His Met Gly Ala Gly Ser Leu Pro Thr Leu Gln Pro
 455                 460                 465                 470

 gtg gct cct gga ggc ccc ggt gca aaa gcc t gatcaccatg cctgaaactc     1676
 Val Ala Pro Gly Gly Pro Gly Ala Lys Ala 
                 475                 480

 cctttccagg actctcatcc ctgggcacag aattcaggaa actgctagac agcctggtcc   1736

 gaaagcattg ccagctgccc gtttcctccc atggcccagt atgaggccag caggggacat   1796

 ttgggatgcc caggccgcag aggaagctgg gcactgggtg cagaacaagg gcaaggacag   1856

 gctctgagtg tccagtggca gccagaacag gtgacacaga gcaggggctt cagccacaga   1916

 gacacactca ggaggccaga agccgacact caaggtgttc gtggggctgg ctcctgaagg   1976

 gcctgggagg gtccatcagc tgcctccagc atccagtggc tgctggcata cagcctcatc   2036

 cccacgtccc aacccctctc ctgtgtgtct gtgaccctgt gcgctgtctc tgtgtgtacc   2096

 ccccacctgc tccccccccc tttttttttt gagacggggc cttgctgtgt cccccaggcg   2156

 ggagtgcagt gccatgatca tagctcactg cagccttgaa tccctgggct caagtgttcc   2216

 tcctgcctcg tcctcctgag tagctggggt tacaggtgtg tgccgccatg cccagtctct   2276

 tttttggtag ggccaccact cactgggttt agggttcccc aatacactgt gacctcatct   2336

 taactaatta tatcatcaaa acccgtgttt ccaaataagg tcacattctg aggtctgggt   2396

 gcacatgaat ttgagggacc cctcgtctgc tgcagggagc cctgctgtac cccagccttc   2456

 ccaggacgtg gtctccagct tcttcatcct gccagagatt ccaaatggag cccggggctc   2516

 tgcagcattc cagtcccctt tgcagatcca tagctgctct gcagggcgga agacacctgg   2576

 ggcgggaaag cacccctgag ttccatcttc ctgacatgtc gcctgggatg tgacgggcct   2636

 gacatctccc cagggccggg gcccagggct gcctttgctc ctggcccctt agtgtctgga   2696

 atgtggcctt ccacggttgc cccactttgt ctttctaagg taagaagcct tcaccttcca   2756

 gcttttgtct ggcctgtgct gcgtgggagc cactggtctg tgcacatcca cggtgggtga   2816

 gtggccaaga caagcagtgt gatagagtcc ttggtgggtt tagtcatctc ggaagtcgta   2876

 gggcagctat ggaaaccact gggttctgga acgttccagc caggcagtgg ttgttcctca   2936

 taggtaggtg gccttggcct tcatcccagc ctgggatgct ccattgcatt tgtcacctag   2996

 tcactgtata tacgtgcaca tttgaccttt tggcacagcc caggttccag gtgcgtgacc   3056

 tgcccttttt ctcattccct taactgacat tatttagtgt cagaggccga gcacagtggc   3116

 tcccacctat aatcctagca ctttgggagg ccaacgcggg tggattgctt gagcccagga   3176

 gttcaagagc agcctgggca atatagaaag acctcttccc taccaaaaaa aaaaaa       3232




      <210> 4
      <211> 5462
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(5460)

      <400> 4
  atg cac ggg aaa gac cag agg ttg gta cgg agc cag cac gtt gaa gga      48
  Met His Gly Lys Asp Gln Arg Leu Val Arg Ser Gln His Val Glu Gly
    1               5                  10                  15

 tgt tgt aag agg atc ggc ttt gat ggt ggc tct caa ttg gtc atc gtc       96
 Cys Cys Lys Arg Ile Gly Phe Asp Gly Gly Ser Gln Leu Val Ile Val
              20                  25                  30

 aac ttc cca tgg cct gcc att atg ctc ctc atc ttc ttc att atg ctc      144
 Asn Phe Pro Trp Pro Ala Ile Met Leu Leu Ile Phe Phe Ile Met Leu
          35                  40                  45

 ctc atc ttc ttt gca aaa cct ttt gaa cca cca ctg tgc ctg agc atg      192
 Leu Ile Phe Phe Ala Lys Pro Phe Glu Pro Pro Leu Cys Leu Ser Met
      50                  55                  60

 ccc acc agt gag acc gag tcc gtc aac acc gaa aac gtg gct gga ggt      240
 Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala Gly Gly
  65                  70                  75                  80

 gac atc gag gga gaa aac tgc ggg gcc agg ctg gca gac agc gag gtt      288
 Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala Asp Ser Glu Val
                  85                  90                  95

 agg gcc ctg agt cct gct ggc cac cct ttc cat tct gat aaa tgt gac      336
 Arg Ala Leu Ser Pro Ala Gly His Pro Phe His Ser Asp Lys Cys Asp
             100                 105                 110

 ctg gga gag aag cag cca gaa gag tgt gag aag tca ctg aag ggc att      384
 Leu Gly Glu Lys Gln Pro Glu Glu Cys Glu Lys Ser Leu Lys Gly Ile
         115                 120                 125

 cag aac aga gct gag tgg gag gtt gat ttg gtt agt tct gag ctc ctg      432
 Gln Asn Arg Ala Glu Trp Glu Val Asp Leu Val Ser Ser Glu Leu Leu
     130                 135                 140

 aag gat cac tgc gac gtc agg aaa aga gca ggg agg aat gag aag ctg      480
 Lys Asp His Cys Asp Val Arg Lys Arg Ala Gly Arg Asn Glu Lys Leu
 145                 150                 155                 160

 caa gag cct gac aca gcc ttc tct ccc tcc tcg ctc ttc ttc aag aat      528
 Gln Glu Pro Asp Thr Ala Phe Ser Pro Ser Ser Leu Phe Phe Lys Asn
                 165                 170                 175

 ccg ctc aac ctg agc cac cgg atc tcc aag tca aag ttc agc cgc tac      576
 Pro Leu Asn Leu Ser His Arg Ile Ser Lys Ser Lys Phe Ser Arg Tyr
             180                 185                 190

 tgg cgc cgg tgg aat cgg ttc tgc aga agg aag tgc cgc gcc gca gtc      624
 Trp Arg Arg Trp Asn Arg Phe Cys Arg Arg Lys Cys Arg Ala Ala Val
         195                 200                 205

 aag tct aat gtc ttc tac tgg ctg gtg att ttc ctg gtg ttc ctc aac      672
 Lys Ser Asn Val Phe Tyr Trp Leu Val Ile Phe Leu Val Phe Leu Asn
     210                 215                 220

 acg ctc acc att gcc tct gag cac tac aac cag ccc aac tgg ctc aca      720
 Thr Leu Thr Ile Ala Ser Glu His Tyr Asn Gln Pro Asn Trp Leu Thr
 225                 230                 235                 240

 gaa gtc caa gac acg gca aac aag gcc ctg ctg gcc ctg ttc acg gca      768
 Glu Val Gln Asp Thr Ala Asn Lys Ala Leu Leu Ala Leu Phe Thr Ala
                 245                 250                 255

 gag atg ctc ctg aag atg tac agc ctg ggc ctg cag gcc tac ttc gtg      816
 Glu Met Leu Leu Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val
             260                 265                 270

 tcc ctc ttc aac cgc ttt gac tgc ttc gtc gtg tgt ggc ggc atc ctg      864
 Ser Leu Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu
         275                 280                 285

 gag acc atc ctg gtg gag acc aag atc atg tcc cca ctg ggc atc tcc      912
 Glu Thr Ile Leu Val Glu Thr Lys Ile Met Ser Pro Leu Gly Ile Ser
     290                 295                 300

 gtg ctc aga tgc gtc cgg ctg ctg agg att ttc aag atc acg agg tac      960
 Val Leu Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Ile Thr Arg Tyr
 305                 310                 315                 320

 tgg aac tcc ttg agc aac ctg gtg gca tcc ttg ctg aac tct gtg cgc     1008
 Trp Asn Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Val Arg
                 325                 330                 335

 tcc atc gcc tcc ctg ctc ctt ctc ctc ttc ctc ttc atc atc atc ttc     1056
 Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe
             340                 345                 350

 tcc ctc ctg ggg atg cag ctc ttt gga gga aag ttc aac ttt gat gag     1104
 Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu
         355                 360                 365

 atg cag acc cgg agg agc aca ttc gat aac ttc ccc cag tcc ctc ctc     1152
 Met Gln Thr Arg Arg Ser Thr Phe Asp Asn Phe Pro Gln Ser Leu Leu
     370                 375                 380

 act gtg ttt cag atc ctg acc ggg gag gac tgg aat tcg gtg atg tat     1200
 Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ser Val Met Tyr
 385                 390                 395                 400

 gat ggg atc atg gct tat ggc ggc ccc tct ttt cca ggg atg tta gtc     1248
 Asp Gly Ile Met Ala Tyr Gly Gly Pro Ser Phe Pro Gly Met Leu Val
                 405                 410                 415

 tgt att tac ttc atc atc ctc ttc atc tgt gga aac tgt atc ctt tgc     1296
 Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Cys Ile Leu Cys
             420                 425                 430

 tgc tgc ccc cca ccc ctg cgg ccc cca gcc ccc agc ctg cag cac agt     1344
 Cys Cys Pro Pro Pro Leu Arg Pro Pro Ala Pro Ser Leu Gln His Ser
         435                 440                 445

 gcc aaa cgg gca cgc ccc tca gaa tgg aca caa aca gat atc cta ctg     1392
 Ala Lys Arg Ala Arg Pro Ser Glu Trp Thr Gln Thr Asp Ile Leu Leu
     450                 455                 460

 aat gtg ttc ttg gcc att gct gtg gac aac ctg gct gat gct gag agc     1440
 Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser
 465                 470                 475                 480

 ctc aca tct gcc caa aag gag gag gaa gag gag aag gag aga aag aag     1488
 Leu Thr Ser Ala Gln Lys Glu Glu Glu Glu Glu Lys Glu Arg Lys Lys
                 485                 490                 495

 ctg gcc agg act gcc agc cca gag aag aaa caa gag ttg gtg gag aag     1536
 Leu Ala Arg Thr Ala Ser Pro Glu Lys Lys Gln Glu Leu Val Glu Lys
             500                 505                 510

 ccg gca gtg ggg gaa tcc aag gag gag aag att gag ctg aaa tcc atc     1584
 Pro Ala Val Gly Glu Ser Lys Glu Glu Lys Ile Glu Leu Lys Ser Ile
         515                 520                 525

 acg gct gac gga gag tct cca ccc gcc acc aag atc aac atg gat gac     1632
 Thr Ala Asp Gly Glu Ser Pro Pro Ala Thr Lys Ile Asn Met Asp Asp
     530                 535                 540

 ctc cag ccc aat gaa aat gag gat aag agc ccc tac ccc aac cca gaa     1680
 Leu Gln Pro Asn Glu Asn Glu Asp Lys Ser Pro Tyr Pro Asn Pro Glu
 545                 550                 555                 560

 act aca gga gaa gag gat gag gag gag cca gag atg cct gtc ggc cct     1728
 Thr Thr Gly Glu Glu Asp Glu Glu Glu Pro Glu Met Pro Val Gly Pro
                 565                 570                 575

 cgc cca cga cca ctc tct gag ctt cac ctt aag gaa aag gca gtg ccc     1776
 Arg Pro Arg Pro Leu Ser Glu Leu His Leu Lys Glu Lys Ala Val Pro
             580                 585                 590

 atg cca gaa gcc agc gcg ttt ttc atc ttc agc tct aac aac agg ttt     1824
 Met Pro Glu Ala Ser Ala Phe Phe Ile Phe Ser Ser Asn Asn Arg Phe
         595                 600                 605

 cgc ctc cag tgc cac cgc att gtc aat gac acg atc ttc acc aac ctg     1872
 Arg Leu Gln Cys His Arg Ile Val Asn Asp Thr Ile Phe Thr Asn Leu
     610                 615                 620

 atc ctc ttc ttc att ctg ctc agc agc att tcc ctg gct gct gag gac     1920
 Ile Leu Phe Phe Ile Leu Leu Ser Ser Ile Ser Leu Ala Ala Glu Asp
 625                 630                 635                 640

 ccg gtc cag cac acc tcc ttc agg aac cat att ctg ttt tat ttt gat     1968
 Pro Val Gln His Thr Ser Phe Arg Asn His Ile Leu Phe Tyr Phe Asp
                 645                 650                 655

 att gtt ttt acc acc att ttc acc att gaa att gct ctg aag atc cta     2016
 Ile Val Phe Thr Thr Ile Phe Thr Ile Glu Ile Ala Leu Lys Ile Leu
             660                 665                 670

 ggc aat gca gac tat gtc ttc act agt atc ttt aca tta gaa att atc     2064
 Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe Thr Leu Glu Ile Ile
         675                 680                 685

 ctt aag gac act cag gtg ccc cca gct gcc atc cct gga tgg aaa cac     2112
 Leu Lys Asp Thr Gln Val Pro Pro Ala Ala Ile Pro Gly Trp Lys His
     690                 695                 700

 ccc agc aag ggc ccc ttc cca agt aat ggt gta gaa tta gga aag cag     2160
 Pro Ser Lys Gly Pro Phe Pro Ser Asn Gly Val Glu Leu Gly Lys Gln
 705                 710                 715                 720

 gac cga ggt ggc tgg caa tca gaa aaa aag ggt caa aga gga aca att     2208
 Asp Arg Gly Gly Trp Gln Ser Glu Lys Lys Gly Gln Arg Gly Thr Ile
                 725                 730                 735

 agc act ggg tac ctg agt ctg gct ttt cct gat gcc ctg aac acc aca     2256
 Ser Thr Gly Tyr Leu Ser Leu Ala Phe Pro Asp Ala Leu Asn Thr Thr
             740                 745                 750

 gat gac ttt caa atg act gct tat ggg gct ttc ttg cac aag ggt tct     2304
 Asp Asp Phe Gln Met Thr Ala Tyr Gly Ala Phe Leu His Lys Gly Ser
         755                 760                 765

 ttc tgc cgg aac tac ttc aac atc ctg gac ctg ctg gtg gtc agc gtg     2352
 Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val Val Ser Val
     770                 775                 780

 tcc ctc atc tcc ttt ggc atc cag tcc agt gca atc aat gtc gtg aag     2400
 Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn Val Val Lys
 785                 790                 795                 800

 atc ttg cga gtc ctg cga gta ctc agg ccc ctg agg gcc atc aac agg     2448
 Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg
                 805                 810                 815

 gcc aag ggg cta aag cat gtg gtt cag tgt gtg ttt gtc gcc atc cgg     2496
 Ala Lys Gly Leu Lys His Val Val Gln Cys Val Phe Val Ala Ile Arg
             820                 825                 830

 acc atc ggg aac atc gtg att gtc acc acc ctg ctg cag ttc atg ttt     2544
 Thr Ile Gly Asn Ile Val Ile Val Thr Thr Leu Leu Gln Phe Met Phe
         835                 840                 845

 gcc tgc atc ggg gtc cag ctc ttc aag gga aag ctg tac acc tgt tca     2592
 Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys Leu Tyr Thr Cys Ser
     850                 855                 860

 gac agt tcc aag cag aca gag gcg gaa tgc aag ggc aac tac atc acg     2640
 Asp Ser Ser Lys Gln Thr Glu Ala Glu Cys Lys Gly Asn Tyr Ile Thr
 865                 870                 875                 880

 tac aaa gac ggg gag gtt gac cac ccc atc atc caa ccc cgc agc tgg     2688
 Tyr Lys Asp Gly Glu Val Asp His Pro Ile Ile Gln Pro Arg Ser Trp
                 885                 890                 895

 gag aac agc aag ttt gac ttt gac aat gtt ctg gca gcc atg atg gcc     2736
 Glu Asn Ser Lys Phe Asp Phe Asp Asn Val Leu Ala Ala Met Met Ala
             900                 905                 910

 ctc ttc acc gtc tcc acc ttc gaa ggg tgg cca gac atg agc cac gat     2784
 Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro Asp Met Ser His Asp
         915                 920                 925

 gtc aga gat ctc tgt cat tac cct tat ggc atc tgg gag ttg ggt gtg     2832
 Val Arg Asp Leu Cys His Tyr Pro Tyr Gly Ile Trp Glu Leu Gly Val
     930                 935                 940

 ggg aga gct tct cca ggt gtg ggc cct gtg gtc acc ata gga ttc aag     2880
 Gly Arg Ala Ser Pro Gly Val Gly Pro Val Val Thr Ile Gly Phe Lys
 945                 950                 955                 960

 att gcc act ccc agc atg ccc ttc att ggg ctg ctg tac cgc tcc atc     2928
 Ile Ala Thr Pro Ser Met Pro Phe Ile Gly Leu Leu Tyr Arg Ser Ile
                 965                 970                 975

 gac tcc cac acg gaa gac aag ggc ccc atc tac aac tac cgt gtg gag     2976
 Asp Ser His Thr Glu Asp Lys Gly Pro Ile Tyr Asn Tyr Arg Val Glu
             980                 985                 990

 atc tcc atc ttc ttc atc atc tac atc atc atc atc gcc ttc ttc atg     3024
 Ile Ser Ile Phe Phe Ile Ile Tyr Ile Ile Ile Ile Ala Phe Phe Met
         995                1000                1005

 atg aac atc ttc gtg ggc ttc gtc atc gtc acc ttt cag gag cag ggg     3072
 Met Asn Ile Phe Val Gly Phe Val Ile Val Thr Phe Gln Glu Gln Gly
    1010                1015                1020

 gag cag gag tac aag aac tgt gag ctg gac aag aac cag cga cag tgc     3120
 Glu Gln Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn Gln Arg Gln Cys
1025                1030                1035                1040

 gtg gaa tac gcc ctc aag gcc cgg ccc ctg cgg agg tac atc ccc aag     3168
 Val Glu Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg Tyr Ile Pro Lys
                1045                1050                1055

 aac cag cac cag tac aaa gtg tgg tac gtg gtc aac tcc acc tac ttc     3216
 Asn Gln His Gln Tyr Lys Val Trp Tyr Val Val Asn Ser Thr Tyr Phe
            1060                1065                1070

 gag tac ctg atg ttc gtc ctc atc ctg ctc aac acc atc tgc ctg gcc     3264
 Glu Tyr Leu Met Phe Val Leu Ile Leu Leu Asn Thr Ile Cys Leu Ala
        1075                1080                1085

 atg cag cac tac ggc cag agc tgc ctg ttc aaa atc gcc atg aac atc     3312
 Met Gln His Tyr Gly Gln Ser Cys Leu Phe Lys Ile Ala Met Asn Ile
    1090                1095                1100

 ctc aac atg ctc ttc act ggc ctc ttc acc gtg gag atg atc ctg aag     3360
 Leu Asn Met Leu Phe Thr Gly Leu Phe Thr Val Glu Met Ile Leu Lys
1105                1110                1115                1120

 ctc att gcc ttc aaa ccc aag gaa aga gga aat gaa ggc agt gaa gcc     3408
 Leu Ile Ala Phe Lys Pro Lys Glu Arg Gly Asn Glu Gly Ser Glu Ala
                1125                1130                1135

 ttg gcc ttg tct gct tct cag aga gta gag agg cag aaa gag gag cgg     3456
 Leu Ala Leu Ser Ala Ser Gln Arg Val Glu Arg Gln Lys Glu Glu Arg
            1140                1145                1150

 ttt ctc cgg tcc ccc acc tgt tgt cct gag gaa tcc atc aac gag gcc     3504
 Phe Leu Arg Ser Pro Thr Cys Cys Pro Glu Glu Ser Ile Asn Glu Ala
        1155                1160                1165

 ctg ggc act tcc ttt atc gag ata gtt ctt gag cgc ctc agt gat gat     3552
 Leu Gly Thr Ser Phe Ile Glu Ile Val Leu Glu Arg Leu Ser Asp Asp
    1170                1175                1180

 gtt gaa gca tgg tac cat ctt tat agg gct cac aga gta gtg cgg gag     3600
 Val Glu Ala Trp Tyr His Leu Tyr Arg Ala His Arg Val Val Arg Glu
1185                1190                1195                1200

 aca cca ata cac aac aaa caa agg ttt cag atg ggg agc ttg tca ctc     3648
 Thr Pro Ile His Asn Lys Gln Arg Phe Gln Met Gly Ser Leu Ser Leu
                1205                1210                1215

 tct ggg gtg gtc tgc cgg aag aga aag cag aga tgg aag gca aag aca     3696
 Ser Gly Val Val Cys Arg Lys Arg Lys Gln Arg Trp Lys Ala Lys Thr
            1220                1225                1230

 gtg gct ccg gag ccg cca tcc gtg ccg tgc tca gca gga ctt agc agc     3744
 Val Ala Pro Glu Pro Pro Ser Val Pro Cys Ser Ala Gly Leu Ser Ser
        1235                1240                1245

 atg gcc acc cag ccc gcc ctg cgt ggc tct gag gag ctg gac agt aga     3792
 Met Ala Thr Gln Pro Ala Leu Arg Gly Ser Glu Glu Leu Asp Ser Arg
    1250                1255                1260

 ggt ttg gtt tgc cac ttc aag gag agc cag gaa aac cct ttc tcc aac     3840
 Gly Leu Val Cys His Phe Lys Glu Ser Gln Glu Asn Pro Phe Ser Asn
1265                1270                1275                1280

 ccc tta ctt ctc aac cat ttg gga cac agt cac cag aga aat aag ggg     3888
 Pro Leu Leu Leu Asn His Leu Gly His Ser His Gln Arg Asn Lys Gly
                1285                1290                1295

 caa cag ggt tac ttt agt gat ccc tgg aat gtt ttt gac ttc ctc atc     3936
 Gln Gln Gly Tyr Phe Ser Asp Pro Trp Asn Val Phe Asp Phe Leu Ile
            1300                1305                1310

 gta att ggc agc ata att gac gtc att ctc agt gag act aat ctc tgc     3984
 Val Ile Gly Ser Ile Ile Asp Val Ile Leu Ser Glu Thr Asn Leu Cys
        1315                1320                1325

 ccg gcg ctg ccg ggc tgg ggc gtg gag ctg agc aga ggg agt ggc ggt     4032
 Pro Ala Leu Pro Gly Trp Gly Val Glu Leu Ser Arg Gly Ser Gly Gly
    1330                1335                1340

 gca ggg gac aca ccg ccc ggc tcc ccg ggg cgg cca cag ccc cac gcc     4080
 Ala Gly Asp Thr Pro Pro Gly Ser Pro Gly Arg Pro Gln Pro His Ala
1345                1350                1355                1360

 acc ttt gaa cta acc cag ctt ttg tca ggc ctc tgc acc ctg cga aaa     4128
 Thr Phe Glu Leu Thr Gln Leu Leu Ser Gly Leu Cys Thr Leu Arg Lys
                1365                1370                1375

 cca ggt tat cca ggt ttg agc tgc cag aac tgt aga gtg cac tat ttc     4176
 Pro Gly Tyr Pro Gly Leu Ser Cys Gln Asn Cys Arg Val His Tyr Phe
            1380                1385                1390

 tgt gat gca tgg aat aca ttt gac gcc ttg att gtt gtg ggt agc att     4224
 Cys Asp Ala Trp Asn Thr Phe Asp Ala Leu Ile Val Val Gly Ser Ile
        1395                1400                1405

 gtt gat ata gca atc acc gag gta aac atg gta ccc aaa gcc ccg gca     4272
 Val Asp Ile Ala Ile Thr Glu Val Asn Met Val Pro Lys Ala Pro Ala
    1410                1415                1420

 cta gag aag aag aag cga caa gag gca gag gag cgg aga ggc ctg ggc     4320
 Leu Glu Lys Lys Lys Arg Gln Glu Ala Glu Glu Arg Arg Gly Leu Gly
1425                1430                1435                1440

 cag ggc ctc tgg cgc gag gag atc ggg acc cgc aaa ctt ctg ttc atc     4368
 Gln Gly Leu Trp Arg Glu Glu Ile Gly Thr Arg Lys Leu Leu Phe Ile
                1445                1450                1455

 tgg gag atg ccg ctg aac aac tgc cag gtg tca caa gag gac cgt ctt     4416
 Trp Glu Met Pro Leu Asn Asn Cys Gln Val Ser Gln Glu Asp Arg Leu
            1460                1465                1470

 cag gcc ccc tca aag acc aca gat ggg aga aac tac aaa cta act cag     4464
 Gln Ala Pro Ser Lys Thr Thr Asp Gly Arg Asn Tyr Lys Leu Thr Gln
        1475                1480                1485

 ggc acc ggc agc aaa tct ggg aag ggg tca gag att aat ggc cca agt     4512
 Gly Thr Gly Ser Lys Ser Gly Lys Gly Ser Glu Ile Asn Gly Pro Ser
    1490                1495                1500

 att gat ggc tac caa caa att ctg aat tta cat cca aag aac gca gag     4560
 Ile Asp Gly Tyr Gln Gln Ile Leu Asn Leu His Pro Lys Asn Ala Glu
1505                1510                1515                1520

 gaa aac tcc cgc atc tcc atc acc ttc ttc cgc ctg ttc cgg gtc atg     4608
 Glu Asn Ser Arg Ile Ser Ile Thr Phe Phe Arg Leu Phe Arg Val Met
                1525                1530                1535

 cgt ctg gtg aag ctg ctg agc cgt ggg gag ggc atc cgg acg ctg ctg     4656
 Arg Leu Val Lys Leu Leu Ser Arg Gly Glu Gly Ile Arg Thr Leu Leu
            1540                1545                1550

 tgg acc ttc atc aag tcc ttc cag gcc ctg ccc tat gtg gcc ctc ctg     4704
 Trp Thr Phe Ile Lys Ser Phe Gln Ala Leu Pro Tyr Val Ala Leu Leu
        1555                1560                1565

 atc gtg atg ctg ttc ttc atc tac gcg gtg atc ggg atg cag gtg ttt     4752
 Ile Val Met Leu Phe Phe Ile Tyr Ala Val Ile Gly Met Gln Val Phe
    1570                1575                1580

 ggg aaa att gcc ctg aat gat acc aca gag atc aac cgg aac aac aac     4800
 Gly Lys Ile Ala Leu Asn Asp Thr Thr Glu Ile Asn Arg Asn Asn Asn
1585                1590                1595                1600

 ttt cag acc ttc ccc cag gcc gtg ctg ctc ctc ttc agg tgt gcc acc     4848
 Phe Gln Thr Phe Pro Gln Ala Val Leu Leu Leu Phe Arg Cys Ala Thr
                1605                1610                1615

 ggg gag gcc tgg cag gac atc atg ctg gcc tgc atg cca ggc aag aag     4896
 Gly Glu Ala Trp Gln Asp Ile Met Leu Ala Cys Met Pro Gly Lys Lys
            1620                1625                1630

 tgt gcc cca gag tcc gag ccc agc aac agc acg gag ggt gaa aca ccc     4944
 Cys Ala Pro Glu Ser Glu Pro Ser Asn Ser Thr Glu Gly Glu Thr Pro
        1635                1640                1645

 tgt ggt agc agc ttt gct gtc ttc tac ttc atc agc ttc tac atg ctc     4992
 Cys Gly Ser Ser Phe Ala Val Phe Tyr Phe Ile Ser Phe Tyr Met Leu
    1650                1655                1660

 tgt gcc ttc ctg atc atc aac ctc ttt gta gct gtc atc atg gac aac     5040
 Cys Ala Phe Leu Ile Ile Asn Leu Phe Val Ala Val Ile Met Asp Asn
1665                1670                1675                1680

 ttt gac tac ctg aca agg gac tgg tcc atc ctt ggt ccc cac cac ctg     5088
 Phe Asp Tyr Leu Thr Arg Asp Trp Ser Ile Leu Gly Pro His His Leu
                1685                1690                1695

 gat gag ttt aaa aga atc tgg gca gag tat gac cct gaa gcc aag ggt     5136
 Asp Glu Phe Lys Arg Ile Trp Ala Glu Tyr Asp Pro Glu Ala Lys Gly
            1700                1705                1710

 cgt atc aaa cac ctg gat gtg gtg acc ctc ctc cgg cgg att cag ccg     5184
 Arg Ile Lys His Leu Asp Val Val Thr Leu Leu Arg Arg Ile Gln Pro
        1715                1720                1725

 cca cta ggt ttt ggg aag ctg tgc cct cac cgc gtg gct tgc aaa cgc     5232
 Pro Leu Gly Phe Gly Lys Leu Cys Pro His Arg Val Ala Cys Lys Arg
    1730                1735                1740

 ctg gtc tcc atg aac atg cct ctg aac agc gac ggg aca gtc atg ttc     5280
 Leu Val Ser Met Asn Met Pro Leu Asn Ser Asp Gly Thr Val Met Phe
1745                1750                1755                1760

 aat gcc acc ctg ttt gcc ctg gtc agg acg gcc ctg agg atc aaa aca     5328
 Asn Ala Thr Leu Phe Ala Leu Val Arg Thr Ala Leu Arg Ile Lys Thr
                1765                1770                1775

 gaa gct ttc cat gaa act ctg gga ctc att ctg ggt ggt atc ttg aag     5376
 Glu Ala Phe His Glu Thr Leu Gly Leu Ile Leu Gly Gly Ile Leu Lys
            1780                1785                1790

 tca gag ggt ata gct cac aaa aca gaa gga gac ggg tgt tac ctg aag     5424
 Ser Glu Gly Ile Ala His Lys Thr Glu Gly Asp Gly Cys Tyr Leu Lys
        1795                1800                1805

 cag gac caa ccc ctg tct aaa aga act tac act ggc ta                  5462
 Gln Asp Gln Pro Leu Ser Lys Arg Thr Tyr Thr Gly 
    1810                1815                1820





      <210> 5
      <211> 1278
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (802)..(1056)

      <400> 5
 tgtgttttta atccttatgt ctttttggca gctcagaagg accagctcca ggtaaacaat     60

 acccagttga cctgtaaatc ttgccagtta tatcactgca ttaatcatag cacattgcga    120

 acacataata tctcgacttt gatgatttta ggttgcatcc ctgggctagg gattcctgtt    180

 aatctgtccg aggcttgggc tgccacacct gctttgcatt ttgtgaaact tcttctactt    240

 caggttactc attgtgcccg tagagcctta ggcatgataa tttttgctat cgtttccttg    300

 gtcacactaa taacttctgt tgtgatgtcc tctgtaactt tgcatagttc tgttcaaacg    360

 gctcagtacg tagagaattg gacacgtaca gccaaccaag cgaggctact tcagaataaa    420

 attaacactg agttacaaac tgaagtggca atgttgaaat ccatggttct gtggttaggg    480

 gaacaagtat aaagcttgca gttgcagcgg caattgcgct gtcattttaa tcacactcgt    540

 atttgtgtaa ccaacttaga atataacaaa agtgagtatc cgtgggacct tgtgaaagcc    600

 catttgcaag gagctttcac atccaacatc acctttgata ttagtgaatt acaaaacaaa    660

 attcttgatt taaataggca cactcaagaa tttcagcctt ctttagaaga ctggactgaa    720

 ttccaggaag gcctggagag cctcaaccct tggacctatc taaagtacca cagtaacatc    780

 ttatatgtag ttcttggagt a  atg ttg ttt tgt ctc tgt ctt ctg ttt ata     831
                          Met Leu Phe Cys Leu Cys Leu Leu Phe Ile
                            1               5                  10

 gtc tgt aaa atc gga tgg acc gcc aat cgg aga atg aga gct gcc cag      879
 Val Cys Lys Ile Gly Trp Thr Ala Asn Arg Arg Met Arg Ala Ala Gln
                  15                  20                  25

 cct ggt ctt aca ttc ttt caa tta att cat aaa cag ggg gat atg cag      927
 Pro Gly Leu Thr Phe Phe Gln Leu Ile His Lys Gln Gly Asp Met Gln
              30                  35                  40

 gga gcc gaa ggc cca tgg gac gtg acc aac tca gca ttc ctc tgg agg      975
 Gly Ala Glu Gly Pro Trp Asp Val Thr Asn Ser Ala Phe Leu Trp Arg
          45                  50                  55

 cta tat gat caa aca gca aac tgt tta tca aga atg cag gat atg ggc     1023
 Leu Tyr Asp Gln Thr Ala Asn Cys Leu Ser Arg Met Gln Asp Met Gly
      60                  65                  70

 aaa ctc aca ctt ccc tgc cac caa aag gtt tgc tgagggac atgtctccct     1074
 Lys Leu Thr Leu Pro Cys His Gln Lys Val Cys 
  75                  80                  85

 tgcaccgggc tccttgaagt tatctaatga gaaatctagc acctattatt caaaggatgc   1134

 agtcttgcaa gcctgctgtg aaccaaacgg ctgactgaca attacctgac aatcaccctg   1194

 cctttctcgc tctctctttt gcctaataaa tatggagggc tgtgtaaagc tcaaaaccct   1254

 tgtcccctag aggcaaaaaa aaaa                                          1278




      <210> 6
      <211> 2019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (140)..(628)

      <400> 6
 cctggtggcg aattcggcac gaggcgccgc gccgcgctgc gacgctgtag tggcttcgtc     60

 ttcggttttt ctcttccttc gctaacgcct cccggctctc gtcagcctcc cgccggccgt    120

 ctccttaaca ccgaacacc atg cct tca att aag ttg cag agt tct gat gga     172
                      Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly
                        1               5                  10

 gag ata ttt gaa gtt gat gtg gaa att gcc aaa caa tct gtg act att      220
 Glu Ile Phe Glu Val Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile
              15                  20                  25

 aag acc atg ttg gaa gat ttg gga atg gat gat gaa gga gat gat gac      268
 Lys Thr Met Leu Glu Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp
          30                  35                  40

 cca gtt cct cta cca aat gtg aat gca gca ata tta aaa aag gtc att      316
 Pro Val Pro Leu Pro Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile
      45                  50                  55

 cag tgg tgc acc cac cac aag gat gac cct cct cct cct gaa gat gat      364
 Gln Trp Cys Thr His His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp
  60                  65                  70                  75

 gag aac aaa gaa aag cga aca gat gat atc cct gtt tgg gac caa gaa      412
 Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu
                  80                  85                  90

 ttc ctg aaa gtt gac caa gga aca ctt ttt gaa ctc att ctg gct gca      460
 Phe Leu Lys Val Asp Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala
              95                 100                 105

 aac tac tta gac atc aaa ggt ttg ctt gat gtt aca tgc aag act gtt      508
 Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val
         110                 115                 120

 gcc aat atg atc aag ggg aaa act cct gag gag att cgc aag acc ttc      556
 Ala Asn Met Ile Lys Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe
     125                 130                 135

 aat atc aaa aat gac ttt act gaa gag gag gaa gcc cag gta cgc aaa      604
 Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys
 140                 145                 150                 155

 gag aac cag tgg tgt gaa gag aag tgaaatgttg tgcctgacac tgtaacactg     658
 Glu Asn Gln Trp Cys Glu Glu Lys 
                 160

 taaggattgt tccaaatact agttgcactg ctctgtttat aattgttaat attagacaaa    718

 cagtagacaa atgcagcagc aagtcaattg tattagcaga atattgtcct cattgcatgt    778

 gtagtttgag cacagatccc aaaccttacg gccaagtttc ttctagtatg atggaaagtt    838

 tcttttttct ttgctctgaa taaaactgaa ctgtgggttc tctataagtg gcattttggg    898

 ctttcctccc ttttttgtaa agcaatgtct gcctagttta ttgtccaagt taactttagg    958

 tgacctttta aaagttggca ttgaaaataa aacaacttgc aaaaaagttt tctggaatag   1018

 aattaacaaa atattatctt tatcatgagt tggaaactgg aaaaaggctt cttgaagtaa   1078

 atgttctgag tggagctact aggatgtctt ccagcctcct gcagtcaagg agtaccactg   1138

 tattgattag cctgtatgta gcagggctcc cttcattgca tctgaggact tggtttcttt   1198

 ttctttattt ttaatcctct tagttttaaa tatattgcct agagactcag ttactaccca   1258

 gtttgtggtt ttttgggaga aatgtaactg gacagttagc ttttcaatta aaaagacact   1318

 taacccatgt gggatgtcat ctttttataa ttagtgttcc catgtggaga aaattattca   1378

 cactacttgc atgtaaagaa taatttaact tttaacatta aaatatgtgg taaaacccag   1438

 aaagcatcca tcatgaatgc aagatacttt caataaaaag taagttatat agtaggtagt   1498

 taagtttgct tttgtggact taaatgtgtc tcttcactta aatgggttga atgtgtatat   1558

 atttgttcag cttgaaaaga cttagtttat atcctagctc actggaggct gctgacataa   1618

 ccataacttc tgtcccttct aattgtcatt tatatgccta actggagcta gtactttaat   1678

 tcttaacaca aaattactct gccattgttt ccagcttccc tcctacaata gaatgaagtt   1738

 tttttgatgg cttgagatgg ctcacaaatt ttgatttttt tttcttcctt gtgctccctt   1798

 tttttctcct tgcttttcca gttaacatct atattcacat gtaatcttgt tttctcttca   1858

 cattcactga gttgttcagg ctcagatcat cccttgacag tagtttgcct tcatctcacc   1918

 tttcatttgt cccaaattca ccttatttaa taaagtccca tatgttgtct cacttaattc   1978

 caatttgttg tctgtaccag agataggaaa ctataatgtg g                       2019




      <210> 7
      <211> 1717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (75)..(524)

      <400> 7
 cacgcgtccg ctggagcggc gcagccggag tggggccgtg aggagaataa aggcagcccc     60

 gttgatgact gaaa  atg aca aag cat cca cct aac aga cga gga atc agc     110
                  Met Thr Lys His Pro Pro Asn Arg Arg Gly Ile Ser
                    1               5                  10

 ttt gaa gtg gga gcc cag ttg gaa gcc cgg gac cgt tta aaa aac tgg      158
 Phe Glu Val Gly Ala Gln Leu Glu Ala Arg Asp Arg Leu Lys Asn Trp
          15                  20                  25

 tat cca gct cac ata gaa gac att gac tac gag gaa gga aaa gta ctc      206
 Tyr Pro Ala His Ile Glu Asp Ile Asp Tyr Glu Glu Gly Lys Val Leu
      30                  35                  40

 atc cat ttc aag cgt tgg aac cat cgt tat gat gag tgg ttc tgc tgg      254
 Ile His Phe Lys Arg Trp Asn His Arg Tyr Asp Glu Trp Phe Cys Trp
  45                  50                  55                  60

 gac agt cct tat tta cgc cct tta gag aaa ata cag ctg agg aaa gag      302
 Asp Ser Pro Tyr Leu Arg Pro Leu Glu Lys Ile Gln Leu Arg Lys Glu
                  65                  70                  75

 ggc ttg cat gaa gag gat gga tct tct gaa ttt caa ata aat gag cag      350
 Gly Leu His Glu Glu Asp Gly Ser Ser Glu Phe Gln Ile Asn Glu Gln
              80                  85                  90

 gtc ctt gct tgc tgg tct gat tgt cgt ttt tac ccg gcc aaa gtc act      398
 Val Leu Ala Cys Trp Ser Asp Cys Arg Phe Tyr Pro Ala Lys Val Thr
          95                 100                 105

 gct gtt aac aag gat ggt act tac act gtg aaa ttt tat gat gga gta      446
 Ala Val Asn Lys Asp Gly Thr Tyr Thr Val Lys Phe Tyr Asp Gly Val
     110                 115                 120

 gtt cag act gtc aaa cat att cat gtc aaa gct ttt tcc aaa gat cag      494
 Val Gln Thr Val Lys His Ile His Val Lys Ala Phe Ser Lys Asp Gln
 125                 130                 135                 140

 gtg aga aat gtg gtt ttg tgc ttt gtg tta t gaataatgct aacattgtag      545
 Val Arg Asn Val Val Leu Cys Phe Val Leu 
                 145                 150

 ttttgcctcc tcaaataaag acattacatt agttagagaa aagcaacagt gaatgtgaag    605

 aaagacaaag aatgataaac ccttaaagac agaaaagcga cccaagcagc ctgataaaga    665

 aggaaagtta atctgttctg aaaaggggaa agtgtcagag aaaagtcttc ccaagaaccg    725

 agaaggaaga caaggaaaac catttccgaa aatgacagag agtattctgg agatgcccaa    785

 gtggataaga aacctgaaaa tgacattgtg aagagtccac aagaaaactt gagggaaccc    845

 aaaagaaaac gaggcagacc cccttccata gctcctactg ctgtggattc aaactctcaa    905

 actttgcaac caataacatt ggaactgaga agaaggaaaa tatcaaaagg atgtgaagtc    965

 ccattaaaac gtcctcggct tgacaaaaat tcatcccagg aaaagtcaaa aaactactcg   1025

 gaaaacactg acaaagactt atcgaggaga cgttcctcca ggctgtccac taatgggacc   1085

 catgagatcc tagatcctga cttggttgta tcagatttgg ttgatacgga tcctttgcaa   1145

 gacacgttgt ctagtaccaa ggaatctgaa gaaggtcagt tgaagtctgc tttggaagct   1205

 ggccaggtct catctgcact gacttgccac tcctttgggg atggatccgg ggctgcaggc   1265

 ttggagttga actgcccatc aatgggagaa aacacgatga aaacagaacc gacttctccc   1325

 cttgtggaat tacaagagat ttcgactgtg gaagtaacaa atacttttaa gaaaacagat   1385

 gattttgggt catctaatgc accagctgtc gacctagacc ataagtttag atgcaaagtt   1445

 gtggactgtt taaaattttt ccgcaaagcc aaactgttgc actatcacat gaagtatttc   1505

 catggaatgg agaagtcact ggagccagaa gagagcccgg gaaagaggca tgtccaaacc   1565

 aggggccctt cagcttcaga caagcccagc caggagaccc tgaccaggaa gcgggtctct   1625

 gccagttccc caactacaaa agacaaggaa aagaataaag agaagaaatt caaggagttt   1685

 gtgagagtga agccaaagaa gaaaaaaaaa aa                                 1717




      <210> 8
      <211> 4613
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(1311)

      <400> 8
 cggaattccc gggtcgacga tttcgtcccc cctccgcgac tgcggataat gagcgcctcg     60

 ggccgcccag cgcagccgga gtatccacct cgatgaccac gggctgagcc ccgcgccgcc    120

 acc  atg tcc gtg gcc ttc gcg tct gcc cgg cca aga ggc aaa ggg gag     168
      Met Ser Val Ala Phe Ala Ser Ala Arg Pro Arg Gly Lys Gly Glu
        1               5                  10                  15

 gtt acg cag caa acc atc cag aag atg ctg gac gag aac cac cac ctg      216
 Val Thr Gln Gln Thr Ile Gln Lys Met Leu Asp Glu Asn His His Leu
                  20                  25                  30

 atc cag tgc atc ctg gag tac cag agc aag ggc aag acg gcc gag tgc      264
 Ile Gln Cys Ile Leu Glu Tyr Gln Ser Lys Gly Lys Thr Ala Glu Cys
              35                  40                  45

 acg cag tac cag cag atc ctg cac cgg aac ctg gta tac ctg gcc acg      312
 Thr Gln Tyr Gln Gln Ile Leu His Arg Asn Leu Val Tyr Leu Ala Thr
          50                  55                  60

 atc gca gac tcc aac cag aac atg cag tcc ctg ctt cct gcc ccg ccc      360
 Ile Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro
      65                  70                  75

 acg cag aac atg aac ctg ggc cct gga gcc ctg act cag agc ggc tcc      408
 Thr Gln Asn Met Asn Leu Gly Pro Gly Ala Leu Thr Gln Ser Gly Ser
  80                  85                  90                  95

 agc cag ggc ctg cac tct cag ggc agc ctg agt gac gcc atc agc acg      456
 Ser Gln Gly Leu His Ser Gln Gly Ser Leu Ser Asp Ala Ile Ser Thr
                 100                 105                 110

 ggc ctg cca ccc tcc tcc ctc ctg cag ggc cag att ggc aac ggg ccg      504
 Gly Leu Pro Pro Ser Ser Leu Leu Gln Gly Gln Ile Gly Asn Gly Pro
             115                 120                 125

 agc cac gtg tcc atg cag cag acg gcg cct aac acg ctg ccc acc acc      552
 Ser His Val Ser Met Gln Gln Thr Ala Pro Asn Thr Leu Pro Thr Thr
         130                 135                 140

 tcc atg agc atc tct ggg ccc ggc tac agc cac gcg gga ccc gcc tcg      600
 Ser Met Ser Ile Ser Gly Pro Gly Tyr Ser His Ala Gly Pro Ala Ser
     145                 150                 155

 cag ggc gtc ccc atg cag ggg caa ggc acc atc ggc aac tac gtg tct      648
 Gln Gly Val Pro Met Gln Gly Gln Gly Thr Ile Gly Asn Tyr Val Ser
 160                 165                 170                 175

 cgg acc aac atc aac atg cag tcc aac cca gtc tcc atg atg cag cag      696
 Arg Thr Asn Ile Asn Met Gln Ser Asn Pro Val Ser Met Met Gln Gln
                 180                 185                 190

 cag gcg gcc acg tcg cac tac agc tcg gcg cag ggc ggc agc cag cac      744
 Gln Ala Ala Thr Ser His Tyr Ser Ser Ala Gln Gly Gly Ser Gln His
             195                 200                 205

 tac cag ggc cag tcg tcc atc gcc atg atg ggg cag ggc agc cag ggg      792
 Tyr Gln Gly Gln Ser Ser Ile Ala Met Met Gly Gln Gly Ser Gln Gly
         210                 215                 220

 agc agc atg atg ggg cag cgg ccc atg gcg ccc tac cgg ccc tcc cag      840
 Ser Ser Met Met Gly Gln Arg Pro Met Ala Pro Tyr Arg Pro Ser Gln
     225                 230                 235

 caa ggc tct tcc cag cag tac ctg ggc cag gag gag tac tat ggc gag      888
 Gln Gly Ser Ser Gln Gln Tyr Leu Gly Gln Glu Glu Tyr Tyr Gly Glu
 240                 245                 250                 255

 cag tac agc cac agc cag ggc gcc gcg gag ccc atg ggc cag cag tac      936
 Gln Tyr Ser His Ser Gln Gly Ala Ala Glu Pro Met Gly Gln Gln Tyr
                 260                 265                 270

 tac ccc gac ggc cat ggc gat tac gcc tac cag cag tca tcc tac acg      984
 Tyr Pro Asp Gly His Gly Asp Tyr Ala Tyr Gln Gln Ser Ser Tyr Thr
             275                 280                 285

 gag cag agc tac gac cgg tcc ttc gag gag tcc acg cag cac tac tat     1032
 Glu Gln Ser Tyr Asp Arg Ser Phe Glu Glu Ser Thr Gln His Tyr Tyr
         290                 295                 300

 gag ggg gga aac tcc cag tac agc cag cag cag gcc ggg tac cag cag     1080
 Glu Gly Gly Asn Ser Gln Tyr Ser Gln Gln Gln Ala Gly Tyr Gln Gln
     305                 310                 315

 ggt gcc gcg cag cag cag acg tac tcc cag cag cag tac ccc agc cag     1128
 Gly Ala Ala Gln Gln Gln Thr Tyr Ser Gln Gln Gln Tyr Pro Ser Gln
 320                 325                 330                 335

 cag agc tac ccc ggg cag cag cag ggc tac ggg tct gcc cag gga gcc     1176
 Gln Ser Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Ser Ala Gln Gly Ala
                 340                 345                 350

 ccg tca cag tac ccc ggc tac cag caa ggc caa ggc cag cag tac gga     1224
 Pro Ser Gln Tyr Pro Gly Tyr Gln Gln Gly Gln Gly Gln Gln Tyr Gly
             355                 360                 365

 agc tac cga gca ccg cag aca gcg ccg tct gcc cag cag cag cgg ccc     1272
 Ser Tyr Arg Ala Pro Gln Thr Ala Pro Ser Ala Gln Gln Gln Arg Pro
         370                 375                 380

 tac ggc tat gaa cag ggc cag tat gga aat tac cag cag taagggacac      1321
 Tyr Gly Tyr Glu Gln Gly Gln Tyr Gly Asn Tyr Gln Gln 
     385                 390                 395

 acattctggc tggagccctt gtggtagcgt gttcatccag gggccggatg ggctggcggc   1381

 agctctggtg aattgtgaca tgttggttac ctgttcgccc agtgccacgt ctgcatgtga   1441

 agcgtgctca tttcatgctg ggtatgacgc cgagcgcaca ccactggcgt gagacagcgc   1501

 ttggtggtgt gatacttttg gtgctgtgta tagtattgta tgtcggtaca cggagaggta   1561

 tccttttttt gtcccccgcc cccttctcaa tgtttctagc tagctttggg ggtcattttg   1621

 tcatcagagc attctgtgcc cagggacagg acagatctcg aggacaccac agtccacctg   1681

 ttcccgtcaa cagacgttag gtctcatttt cctcctcatg cagtgttgta gtgtgggttg   1741

 tcaacttttc tttaactggc tacgccacag ctggacacac atgcagcccc tggagggcag   1801

 cctcttcctg tgcctcgatg gggtgggtgg gagggcatct tctgtgcgtt gggtcagttt   1861

 ctgttacgta acgaaaagga taaacatctc ccacgggaga ggccacagat ggccacttcc   1921

 agagcttgcc cattgcctgt ctctcgccaa ttccgtttat ccaaaaaggt acatgttttt   1981

 gtattaaaaa gtaaacaggg atcagtgact gtattccaaa taaatatgaa tccctaaggg   2041

 ccgtggacaa attgcctaac ccagggccag cggtattgct gaaggaaagg ggcagctctc   2101

 tgggaagtgg gccctcagag attactctgg ctttgaccct tgtttagctg atggtcattt   2161

 ctgggattgg aatatttaat aagcccaatt ctaagttgat aggtaatttt aaatattcaa   2221

 accaaatctt cccaacagtt ggcaagttgt ttattttata ttatttcttc caggacctac   2281

 ttgctcagat ctccaagcaa gcatttcttt tcttttaggg atgtctgaaa gtcacatcca   2341

 gttacattac tgtgttcttt ctaatgaaaa gtaaaggttt tatatagaga aacttgagta   2401

 atttttacat ttctaagaca ttaaatccca tttaaattct gtgtgaacat taaagacagc   2461

 acacttgcaa aagtatggtc aaaggaaaaa aatcccacat ttcaattaac aagtagcatg   2521

 gacatttgat caacctttag ttggaataat aatattcata tttgctatga atccttttaa   2581

 aaaaatcttt ggataaatgc tgacagattt ccaagaacta ccaagaaaat acaagagata   2641

 tccaatgctt gatatatgag gcctagtaat aacgatattt ctctttaatt gatgttttgt   2701

 tttaaaagtt aaaagtaatt cttggcgtgg tggttcacgc ctgtaatccc agcactttgg   2761

 gaggccgaag cgggcggatc acctgaggtc gggagttcga gaccagcctg accaacatgg   2821

 agaaaccccg tccctactaa aaatacaaaa ttagccaggt atggtggtgc atacctgtaa   2881

 tcccagctac tcgggaacct gaggcaggag aatggcttga acccaggaga cagaggttgt   2941

 ggtggggcaa gatcgcacca ttgcacccga gcctaggcaa acaaagagtg aaattccgtc   3001

 tcaaaaaaat aaataaataa ataaataaat aagttaaaat taattcattt atccagagtc   3061

 gggtgcttta gaatttataa gtcacttatg tgttttgctt gaattaattc tgacagcccc   3121

 tatgaggaaa tcatggaggc aggtaacagt tcccatttta gagatgaaga actgaggcac   3181

 agattaaagg acttgcctgt gttgaatacc agtcctgttc taggacattc tcccctctcc   3241

 taggagacgg atgtcacgca caaatgggga gagaagtgtt tattttgtag gcactaaggg   3301

 tttctaaaac ccttaacact ggtaagggct caaaaataaa cgtatgtgtt catattcgat   3361

 caccgaaatg agagttctta attgctaatt gacaaacgcg ttagcaattt cagttaggga   3421

 gtcatctccc ttgattgtgt tcttttcctg tcaattttca tagacctaat ttgcaaactc   3481

 aatcggggac taaaatttcc cactgaaaat gttaaacatt ttagataact gtgaagatag   3541

 tttattttta ttccttgcca atctgggaat atgccttttt tgtgtgtttg tgtgtttttt   3601

 taagtgctgt attaataata ctttctgaaa gaaaaggaca cttaccccaa aacttcaatc   3661

 tgaaatgtct tacattaaga atatcttgaa tgttgtgtat atattttaaa aagcactttg   3721

 caaaatagtt tgtacattta tttcctaatt tatacatgat ttttggtgtt aatatattta   3781

 atgattaata acagaatgtt tatttaatgt gctgtccatt tttatgtaat attatgggga   3841

 aagtgatgcc agcagttcct tttcattatt ctatcttctg tcatatgaat gttgagcaaa   3901

 gcttaggcca acatgaattg tttgtgaagt gtggttgatg gtgctttgtt tttttctgac   3961

 tacttctatg gaaggccagt gaagaagcaa aggaagacat gaaaattgac gctcattctt   4021

 cttcctattg ttccctgaca tccagcaaat tgtgaatttg aaaaatgatg gccagttttc   4081

 agaagtgctg acaaattcat attggtatgc aaaagctcat cacccattaa ggtttgttgt   4141

 tgaatcaaca gtactcagca tattaaaaca gtacatcaga actcatgcca acagtcttta   4201

 tgatgggatt aaggtggaca agatctccta agatctgtga atgggattaa ggtggacaag   4261

 atctcctaag atctgaaaag aaaccttaat acgctcatat ggttggagtg ttaagtgaac   4321

 ctctgatttt gtcagggttt ttctacgtgt aggcgtgaat agggggcacc ccttcaaaac   4381

 tgtacaaaga agacgactgt tttccatttc catttaaaca tttttagcca cttcatttct   4441

 atttattgaa caggtcaaat ttgtcttgtt atttgtgagt acagtacatt taaaaaacat   4501

 ccttatcggt tatttttttt tcagtcggag tttgacgtat aaattgttta tgcttttggt   4561

 gtaatctctt aataaactgg ttcttcaaaa atcatcctaa aaaaaaaaaa aa           4613




      <210> 9
      <211> 1498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(1064)

      <400> 9
 actgaaagtt acgttcataa cttacagagg attagtgtat attttccaac ctgaggcatg     60

 aaattctgag gcttatt   atg gaa aaa cta ctc aag ttg gat gtg aat gca     110
                      Met Glu Lys Leu Leu Lys Leu Asp Val Asn Ala
                        1               5                  10

 tcc cgg cag ggt att gaa gat gct gaa gaa aca gca act caa act tgt      158
 Ser Arg Gln Gly Ile Glu Asp Ala Glu Glu Thr Ala Thr Gln Thr Cys
              15                  20                  25

 ggt ggg aca gat tcc acg gaa gga ttg ttt aat atg gat gaa gat gaa      206
 Gly Gly Thr Asp Ser Thr Glu Gly Leu Phe Asn Met Asp Glu Asp Glu
          30                  35                  40

 gaa act gaa cat gaa aca aag gct ggt cct gaa cgg ctc gac cag atg      254
 Glu Thr Glu His Glu Thr Lys Ala Gly Pro Glu Arg Leu Asp Gln Met
      45                  50                  55

 gtg cat cct gta gcc gag cgc ctg gac atc ctg atg tct ttg gtt ttg      302
 Val His Pro Val Ala Glu Arg Leu Asp Ile Leu Met Ser Leu Val Leu
  60                  65                  70                  75

 tcc tac atg aag gat gtc tgc tat gta gat ggt aag gtt gat aac ggc      350
 Ser Tyr Met Lys Asp Val Cys Tyr Val Asp Gly Lys Val Asp Asn Gly
                  80                  85                  90

 aaa aca aag gat cta tat cgc gac ctg ata aac atc ttt gac aaa ctc      398
 Lys Thr Lys Asp Leu Tyr Arg Asp Leu Ile Asn Ile Phe Asp Lys Leu
              95                 100                 105

 ctg ttg ccc acc cat gcc tcc tgc cat gta cag ttt ttc atg ttt tac      446
 Leu Leu Pro Thr His Ala Ser Cys His Val Gln Phe Phe Met Phe Tyr
         110                 115                 120

 ctc tgt agt ttc aaa ttg gga ttc gca gag gca ttt ttg gaa cat ctc      494
 Leu Cys Ser Phe Lys Leu Gly Phe Ala Glu Ala Phe Leu Glu His Leu
     125                 130                 135

 tgg aaa aaa ttg cag gac cca agt aat cct gcc atc atc agg cag gct      542
 Trp Lys Lys Leu Gln Asp Pro Ser Asn Pro Ala Ile Ile Arg Gln Ala
 140                 145                 150                 155

 gct gga aat tat att gga agc ttt ttg gca aga gct aaa ttt att cct      590
 Ala Gly Asn Tyr Ile Gly Ser Phe Leu Ala Arg Ala Lys Phe Ile Pro
                 160                 165                 170

 ctt att act gta aaa tca tgc cta gat ctt ttg gtt aac tgg ctg cac      638
 Leu Ile Thr Val Lys Ser Cys Leu Asp Leu Leu Val Asn Trp Leu His
             175                 180                 185

 ata tac ctt aat aac cag gat tcg gga aca aag gca ttc tgc gat gtt      686
 Ile Tyr Leu Asn Asn Gln Asp Ser Gly Thr Lys Ala Phe Cys Asp Val
         190                 195                 200

 gct ctc cat gga cca ttt tac tca gcc tgc caa gct gtg ttc tac acc      734
 Ala Leu His Gly Pro Phe Tyr Ser Ala Cys Gln Ala Val Phe Tyr Thr
     205                 210                 215

 ttt gtt ttt aga cac aag cag ctt ttg agc gga aac ctg aaa gaa ggt      782
 Phe Val Phe Arg His Lys Gln Leu Leu Ser Gly Asn Leu Lys Glu Gly
 220                 225                 230                 235

 ttg cag tat ctt cag agt ctg aat ttt gag cgg ata gtg atg agc cag      830
 Leu Gln Tyr Leu Gln Ser Leu Asn Phe Glu Arg Ile Val Met Ser Gln
                 240                 245                 250

 cta aat ccc ctg aag att tgc ctg ccc tca gtg gtt aac ttt ttt gct      878
 Leu Asn Pro Leu Lys Ile Cys Leu Pro Ser Val Val Asn Phe Phe Ala
             255                 260                 265

 gca atc aca aat aag tac cag ctc gtc ttc tgc tac acc atc atc gag      926
 Ala Ile Thr Asn Lys Tyr Gln Leu Val Phe Cys Tyr Thr Ile Ile Glu
         270                 275                 280

 agg aac aat cgc cag atg ctg cca gtc att agg agt acc act gga gga      974
 Arg Asn Asn Arg Gln Met Leu Pro Val Ile Arg Ser Thr Thr Gly Gly
     285                 290                 295

 gac tca gtg cag acc tgc aca aac cca ctg gac acc ttc gtc ccc ttt     1022
 Asp Ser Val Gln Thr Cys Thr Asn Pro Leu Asp Thr Phe Val Pro Phe
 300                 305                 310                 315

 gat ccc tgt gtg ctg aag aga cct gcc ttt cgc ctt ctg cca tgattgg     1071
 Asp Pro Cys Val Leu Lys Arg Pro Ala Phe Arg Leu Leu Pro 
                 320                 325

 gaggcctccc cagccacatg gaactgtgag tccattcaac ttctttttct ttgtaaatta   1131

 cccagtctcg ggtatggctt tatcagcagc atgaaaacag acaaatatac tgttgtttct   1191

 tattaaatgt tattggctta ttttgaaaac aaaagcttac caaatacatg tgattatggg   1251

 aaggggccag aaagttacac tgcaagtaaa aatatcagta actatgttta ctgggtggcg   1311

 atggcaaaaa caatagtttt tccttttttt ttttttggag acaggatctt gctctgtcgc   1371

 ccaggctaca gtgcagtggt gcaatcacgg cccactgcag cctcgacctc cggagctcaa   1431

 ttgatcctcc cacctcagcc tcctgagtgg ctgcatctac agatgtgagc caccaaaaaa   1491

 aaaaaaa                                                             1498




      <210> 10
      <211> 1396
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(393)

      <400> 10
 ctggaagcag ggagggggct tccaggtcac agagagccta cgactagatt tgcatcttta     60

 cgtcctgcgc ggaggctgct acacacatgc agaagtcatg ctggtggcct ggacattgaa    120

 gggagagaag tggatttggg agacatttag gag atg gca ccg aaa gcg aag gaa     174
                                      Met Ala Pro Lys Ala Lys Glu
                                        1               5

 gct cct gct cct cct aaa gcc gaa gcc aaa gcg aag gct tta aag gcc      222
 Ala Pro Ala Pro Pro Lys Ala Glu Ala Lys Ala Lys Ala Leu Lys Ala
          10                  15                  20

 aag aag gca gtg ttg aaa ggt gtc cgc agc cac acg caa aaa aga gga      270
 Lys Lys Ala Val Leu Lys Gly Val Arg Ser His Thr Gln Lys Arg Gly
      25                  30                  35

 tcc gca tgt cac tca cct tca ggc ggc cca aga cac tgc gac tcc gga      318
 Ser Ala Cys His Ser Pro Ser Gly Gly Pro Arg His Cys Asp Ser Gly
  40                  45                  50                  55

 ggc agc cca gat atc ctc aga aga gca ccc cca gga gaa aca agc ttg      366
 Gly Ser Pro Asp Ile Leu Arg Arg Ala Pro Pro Gly Glu Thr Ser Leu
                  60                  65                  70

 gcc act atg cta tca tca agt ttc cgc tgacc actgagtcgg ccgtgaagaa      418
 Ala Thr Met Leu Ser Ser Ser Phe Arg 
              75                  80

 gatagaagaa aacaacatgc ttgtgttcac tgtggatgtt aaagccaaca agcaccagat    478

 cagacaggct gtgaagaagc tctatgacag tgatgtggcc aaggtcacca ccctgatttg    538

 tcctgataaa gagaagaagg catatgttcg acttgctcct gattatgatg ctttcgatgt    598

 tgtaacaaaa ttgggatcac ctaaactgag tccagctggc taactctaaa tatatgtgta    658

 tcttttcagc ataaaaaaat aatgtttttc ataagaatga caacttaatt agaatcaaat    718

 ctataagctt taagatttta cgtttctagt aagtataata ttagcttatt tgactagaac    778

 tcaagcagaa taggaattta tgcttgtttt atattcaata atgataattt tgaagatata    838

 gttgttttat tacaccaaaa atactatatt aatcttattt aactaagttt tatccaaatc    898

 atgttaactt aagaaacatt tgatcagttc ctatatttct aggagtttgg tgaatattta    958

 tttataaatg cttatttttt tccaagccaa gttagaatag agcactttta gaggatttca   1018

 taaatgaatt ttgtaatgct ctctggagtt aagaaaatat cacatataca taacgtacat   1078

 taatagatac acaaacacaa atagagattt catagctttc atcctgaaat ttcagccatg   1138

 aatcaggcat aaatattctg atggttaatt tcagacatct acttgatcgg attgagagac   1198

 acacatagct ggtcaaacac gatttcagcc atgaatcagg cataaatatt ctgatggtta   1258

 attttagaca tctacttgag tggattaaga gacacacgta gctggtcaaa catgatttca   1318

 gccatgaatc agccataaat attctgatgg ttaattttag acatctactt gagtggatta   1378

 agagacacac cctgtatt                                                 1396




      <210> 11
      <211> 2944
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(2941)

      <400> 11
 cgcggccgcg tgaggacgag gctatttgaa aacacgctcc gggagctaga gcctgaggtc     60

 ggcggcgcac gctgttgccc cgtgggcttc tgctccctcg cttgtcttct cgggcttctc    120

 gccccggccg cggccgggtc ctcagtagtc gaga    atg act aaa aaa aga aaa     172
                                          Met Thr Lys Lys Arg Lys
                                            1               5

 cgc caa cat gat ttt caa aaa gta aaa ttg aaa gtt ggt aaa aag aag      220
 Arg Gln His Asp Phe Gln Lys Val Lys Leu Lys Val Gly Lys Lys Lys
              10                  15                  20

 ccc aag tta caa aat gct act cct aca aac ttt aaa aca aag act ata      268
 Pro Lys Leu Gln Asn Ala Thr Pro Thr Asn Phe Lys Thr Lys Thr Ile
          25                  30                  35

 cat ctg cct gag caa ctc aaa gag gat gga aca ctt cca aca aac aat      316
 His Leu Pro Glu Gln Leu Lys Glu Asp Gly Thr Leu Pro Thr Asn Asn
      40                  45                  50

 aga aaa ctt aac ata aag gat ttg ctg tca cag atg cat cac tac aat      364
 Arg Lys Leu Asn Ile Lys Asp Leu Leu Ser Gln Met His His Tyr Asn
  55                  60                  65                  70

 gct ggg gtt aaa caa agt gct ctt ctt gga ctt aaa gac ctt ttg tct      412
 Ala Gly Val Lys Gln Ser Ala Leu Leu Gly Leu Lys Asp Leu Leu Ser
                  75                  80                  85

 caa tac cca ttt ata att gat gca cac ctt tca aac ata tta agt gaa      460
 Gln Tyr Pro Phe Ile Ile Asp Ala His Leu Ser Asn Ile Leu Ser Glu
              90                  95                 100

 gtg act gct gtg ttt aca gat aaa gat gct aat gta cga tta gca gca      508
 Val Thr Ala Val Phe Thr Asp Lys Asp Ala Asn Val Arg Leu Ala Ala
         105                 110                 115

 gtt caa ctt ctt caa ttc ctg gcc ccc aaa ata cga gct gaa caa att      556
 Val Gln Leu Leu Gln Phe Leu Ala Pro Lys Ile Arg Ala Glu Gln Ile
     120                 125                 130

 tct cca ttt ttt cct ttg gta agt gcc cat ctc tct agt gcc atg act      604
 Ser Pro Phe Phe Pro Leu Val Ser Ala His Leu Ser Ser Ala Met Thr
 135                 140                 145                 150

 cac att act gaa gga att cag gag gac tct tta aaa gtt ttg gac att      652
 His Ile Thr Glu Gly Ile Gln Glu Asp Ser Leu Lys Val Leu Asp Ile
                 155                 160                 165

 ctg ctg gaa cag tac cca gct cta att act ggc cgt agc agc ata ttg      700
 Leu Leu Glu Gln Tyr Pro Ala Leu Ile Thr Gly Arg Ser Ser Ile Leu
             170                 175                 180

 ctt aag aat ttt gta gaa ctt att tct cat cag cag ctg tcc aaa gga      748
 Leu Lys Asn Phe Val Glu Leu Ile Ser His Gln Gln Leu Ser Lys Gly
         185                 190                 195

 ctg ata aat aga gac aga tcc cag tcc tgg ata ctt tct gta aat cct      796
 Leu Ile Asn Arg Asp Arg Ser Gln Ser Trp Ile Leu Ser Val Asn Pro
     200                 205                 210

 aat cgg aga ctc act tct cag caa tgg agg ctg aaa gtc tta gtg aga      844
 Asn Arg Arg Leu Thr Ser Gln Gln Trp Arg Leu Lys Val Leu Val Arg
 215                 220                 225                 230

 ctc agt aaa ttc ctt cag gcc ttg gca gat gga tcc agt agg ttg aga      892
 Leu Ser Lys Phe Leu Gln Ala Leu Ala Asp Gly Ser Ser Arg Leu Arg
                 235                 240                 245

 gaa agt gaa gga ctt cag gaa cag aaa gaa aat ccc cat gcc act agc      940
 Glu Ser Glu Gly Leu Gln Glu Gln Lys Glu Asn Pro His Ala Thr Ser
             250                 255                 260

 aac tcc att ttt atc aac tgg aag gaa cat gcc aac gac cag caa cac      988
 Asn Ser Ile Phe Ile Asn Trp Lys Glu His Ala Asn Asp Gln Gln His
         265                 270                 275

 atc cag gtt tat gaa aat ggg ggt tca cag cca aat gtc agt tca cag     1036
 Ile Gln Val Tyr Glu Asn Gly Gly Ser Gln Pro Asn Val Ser Ser Gln
     280                 285                 290

 ttc agg cta cgg tat ctg gtt gga gga ctg agt ggt gtg gat gaa ggc     1084
 Phe Arg Leu Arg Tyr Leu Val Gly Gly Leu Ser Gly Val Asp Glu Gly
 295                 300                 305                 310

 ctg tca tct act gaa aac ctg aaa gga ttt att gag ata ata att cca     1132
 Leu Ser Ser Thr Glu Asn Leu Lys Gly Phe Ile Glu Ile Ile Ile Pro
                 315                 320                 325

 ttg cta att gaa tgc tgg gtt gaa gct gta cct cca caa cta gct act     1180
 Leu Leu Ile Glu Cys Trp Val Glu Ala Val Pro Pro Gln Leu Ala Thr
             330                 335                 340

 cct gtt ggg aat ggt ata gaa cga gaa cct cta cag gtt atg cag caa     1228
 Pro Val Gly Asn Gly Ile Glu Arg Glu Pro Leu Gln Val Met Gln Gln
         345                 350                 355

 gtt ctt aat att att tcc ctt ctg tgg aaa ctc tct aaa caa cag gat     1276
 Val Leu Asn Ile Ile Ser Leu Leu Trp Lys Leu Ser Lys Gln Gln Asp
     360                 365                 370

 gaa acc cat aaa ttg gag tca tgg ctt cga aag aac tac ctt att gat     1324
 Glu Thr His Lys Leu Glu Ser Trp Leu Arg Lys Asn Tyr Leu Ile Asp
 375                 380                 385                 390

 ttt aaa cac cat ttt atg agt cgt ttt cca tat gtc tta aaa gaa ata     1372
 Phe Lys His His Phe Met Ser Arg Phe Pro Tyr Val Leu Lys Glu Ile
                 395                 400                 405

 acc aag cac aaa agg aaa gag cca aat aaa agc atc aag cat tgc aca     1420
 Thr Lys His Lys Arg Lys Glu Pro Asn Lys Ser Ile Lys His Cys Thr
             410                 415                 420

 gtt ctc tcc aat aac ata gat cat ctc tta ctg aat tta aca ctg tct     1468
 Val Leu Ser Asn Asn Ile Asp His Leu Leu Leu Asn Leu Thr Leu Ser
         425                 430                 435

 gat atc atg gtc tcc ctg gca aat gcg tca act ttg cag aag gat tgc     1516
 Asp Ile Met Val Ser Leu Ala Asn Ala Ser Thr Leu Gln Lys Asp Cys
     440                 445                 450

 agt tgg ata gaa atg ata agg aaa ttt gta aca gag acc ctt gaa gat     1564
 Ser Trp Ile Glu Met Ile Arg Lys Phe Val Thr Glu Thr Leu Glu Asp
 455                 460                 465                 470

 ggc tct agg cta aat agt aag caa ctg aac aga ttg ctg gga gta tcc     1612
 Gly Ser Arg Leu Asn Ser Lys Gln Leu Asn Arg Leu Leu Gly Val Ser
                 475                 480                 485

 tgg agg tta atg caa ata cag cca aac aga gag gac aca gag act ctt     1660
 Trp Arg Leu Met Gln Ile Gln Pro Asn Arg Glu Asp Thr Glu Thr Leu
             490                 495                 500

 att aag gca gtt tat aca tta tat cag cag agg ggc ctt atc ctt cca     1708
 Ile Lys Ala Val Tyr Thr Leu Tyr Gln Gln Arg Gly Leu Ile Leu Pro
         505                 510                 515

 gtt cgg act ttg tta ttg aag ttt ttc agt aaa atc tat cag aca gaa     1756
 Val Arg Thr Leu Leu Leu Lys Phe Phe Ser Lys Ile Tyr Gln Thr Glu
     520                 525                 530

 gaa ctg aga tct tgt aga ttc aga tat cgt agt aaa gtg tta tcc cgt     1804
 Glu Leu Arg Ser Cys Arg Phe Arg Tyr Arg Ser Lys Val Leu Ser Arg
 535                 540                 545                 550

 tgg ctg gct ggc tta cca ttg caa ctt gct cat ctt ggc tcc cga aat     1852
 Trp Leu Ala Gly Leu Pro Leu Gln Leu Ala His Leu Gly Ser Arg Asn
                 555                 560                 565

 cct gag ctc tct aca cag ctt atc gat atc att cat acc gct gca gca     1900
 Pro Glu Leu Ser Thr Gln Leu Ile Asp Ile Ile His Thr Ala Ala Ala
             570                 575                 580

 cga gca aat aaa gaa tta cta aaa agt tta caa gct act gcc ctc cga     1948
 Arg Ala Asn Lys Glu Leu Leu Lys Ser Leu Gln Ala Thr Ala Leu Arg
         585                 590                 595

 att tat gat cca caa gaa ggt gct gtg gtg gtt ctc cct gca gac tct     1996
 Ile Tyr Asp Pro Gln Glu Gly Ala Val Val Val Leu Pro Ala Asp Ser
     600                 605                 610

 cag cag cgt ttg gtt cag ctt gta tat ttc cta ccc agt ctg ccg gct     2044
 Gln Gln Arg Leu Val Gln Leu Val Tyr Phe Leu Pro Ser Leu Pro Ala
 615                 620                 625                 630

 gat ttg ctt tct cgg tta agt cgt tgc tgt att atg gga aga ctc agt     2092
 Asp Leu Leu Ser Arg Leu Ser Arg Cys Cys Ile Met Gly Arg Leu Ser
                 635                 640                 645

 tca agt ttg gct gcc atg ctt atc ggg ata ctg cac atg aga tca tca     2140
 Ser Ser Leu Ala Ala Met Leu Ile Gly Ile Leu His Met Arg Ser Ser
             650                 655                 660

 ttt tct ggg tgg aag tat tca gct aaa gac tgg ttg atg agt gat gta     2188
 Phe Ser Gly Trp Lys Tyr Ser Ala Lys Asp Trp Leu Met Ser Asp Val
         665                 670                 675

 gac tat ttc agt ttc tta ttt tcc aca ctt aca ggg ttt tcg aaa gag     2236
 Asp Tyr Phe Ser Phe Leu Phe Ser Thr Leu Thr Gly Phe Ser Lys Glu
     680                 685                 690

 gag ttg act tgg ctt cag agc ctt cga gga gtt cct cat gtc atc cag     2284
 Glu Leu Thr Trp Leu Gln Ser Leu Arg Gly Val Pro His Val Ile Gln
 695                 700                 705                 710

 aca cag ctt tcc cct gtg ctt ctc tac ctt aca gat ttg gat caa ttt     2332
 Thr Gln Leu Ser Pro Val Leu Leu Tyr Leu Thr Asp Leu Asp Gln Phe
                 715                 720                 725

 tta cac cac tgg gat gta aca gag gca gtt ttt cac agt tta ttg gtt     2380
 Leu His His Trp Asp Val Thr Glu Ala Val Phe His Ser Leu Leu Val
             730                 735                 740

 att cct gcc cga agt cag aac ttt gac atc ttg caa agt gcc atc agt     2428
 Ile Pro Ala Arg Ser Gln Asn Phe Asp Ile Leu Gln Ser Ala Ile Ser
         745                 750                 755

 aag cat ttg gtt ggg ttg act gta att cct gac agc acg gct ggc tgt     2476
 Lys His Leu Val Gly Leu Thr Val Ile Pro Asp Ser Thr Ala Gly Cys
     760                 765                 770

 gtt ttt ggt gtt atc tgt aag ctc ctg gat cat act tgt gta gtt agt     2524
 Val Phe Gly Val Ile Cys Lys Leu Leu Asp His Thr Cys Val Val Ser
 775                 780                 785                 790

 gag act cta ctg cca ttt ctg gct tct tgt tgc tac agt ctt ctt tat     2572
 Glu Thr Leu Leu Pro Phe Leu Ala Ser Cys Cys Tyr Ser Leu Leu Tyr
                 795                 800                 805

 ttt ctg ctc act ata gag aaa ggg gaa gca gaa cat cta aga aag agg     2620
 Phe Leu Leu Thr Ile Glu Lys Gly Glu Ala Glu His Leu Arg Lys Arg
             810                 815                 820

 gac aag ctg tgg ggg gtc tgt gtc tcc atc ctg gct ctc ttg cct cga     2668
 Asp Lys Leu Trp Gly Val Cys Val Ser Ile Leu Ala Leu Leu Pro Arg
         825                 830                 835

 gtc ctc agg ttg atg ctg cag agc ctg cgg gtg aac aga gtt ggg cct     2716
 Val Leu Arg Leu Met Leu Gln Ser Leu Arg Val Asn Arg Val Gly Pro
     840                 845                 850

 gag gag ctg cct gtt gtg ggc cag ctg ctt cga ctg ctg ctt cag cat     2764
 Glu Glu Leu Pro Val Val Gly Gln Leu Leu Arg Leu Leu Leu Gln His
 855                 860                 865                 870

 gca ccc ctc agg act cat atg ttg acc aat gcg atc ttg gtg cag cag     2812
 Ala Pro Leu Arg Thr His Met Leu Thr Asn Ala Ile Leu Val Gln Gln
                 875                 880                 885

 atc atc aag aat atc acg aca ttg aag agt gga agt gtt cag gaa cag     2860
 Ile Ile Lys Asn Ile Thr Thr Leu Lys Ser Gly Ser Val Gln Glu Gln
             890                 895                 900

 tgg ctc aca gac tta cat tac tgc ttt aac gtg tat atc act ggg cat     2908
 Trp Leu Thr Asp Leu His Tyr Cys Phe Asn Val Tyr Ile Thr Gly His
         905                 910                 915

 ccc caa ggg ccc agt gca ctg gct aca gtg tat tga                     2944
 Pro Gln Gly Pro Ser Ala Leu Ala Thr Val Tyr 
     920                 925





      <210> 12
      <211> 2156
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(1808)

      <400> 12
 gcgagtcggg tggtcccttt ggctggagtg cctctctggt ctggggatca cctcaggcgc     60

 tgtccttcac tgggcgatcc agc    atg gac ccc gag gac gaa ggg gta gcg     110
                              Met Asp Pro Glu Asp Glu Gly Val Ala
                                1               5

 gga gtg atg tct gtg ggg ccg ccg gcg gcc cgg ctt cag gaa cca gtg      158
 Gly Val Met Ser Val Gly Pro Pro Ala Ala Arg Leu Gln Glu Pro Val
  10                  15                  20                  25

 acc ttc cgg gat gtg gct gtg gac ttt acc cag gag gaa tgg ggg cag      206
 Thr Phe Arg Asp Val Ala Val Asp Phe Thr Gln Glu Glu Trp Gly Gln
                  30                  35                  40

 ctg gac cct acc cag agg atc ctc tac cgt gac gtg atg ctg gag acc      254
 Leu Asp Pro Thr Gln Arg Ile Leu Tyr Arg Asp Val Met Leu Glu Thr
              45                  50                  55

 ttt ggt cac ctg ctc tcc ata ggt cct gag ctt ccg aag cct gaa gtc      302
 Phe Gly His Leu Leu Ser Ile Gly Pro Glu Leu Pro Lys Pro Glu Val
          60                  65                  70

 atc tcc cag ctg gag caa ggg acc gag cta tgg gtg gct gag aga gga      350
 Ile Ser Gln Leu Glu Gln Gly Thr Glu Leu Trp Val Ala Glu Arg Gly
      75                  80                  85

 acc acc cag ggc tgc cat cca gcc tgg gag cct cga tct gaa agc caa      398
 Thr Thr Gln Gly Cys His Pro Ala Trp Glu Pro Arg Ser Glu Ser Gln
  90                  95                 100                 105

 gca tca cgc aag gaa gag ggc ctg cct gaa gag gag cca tcc cat gtc      446
 Ala Ser Arg Lys Glu Glu Gly Leu Pro Glu Glu Glu Pro Ser His Val
                 110                 115                 120

 acg gga agg gaa gga ttc ccg aca gat gct cct tat ccc acc acg tta      494
 Thr Gly Arg Glu Gly Phe Pro Thr Asp Ala Pro Tyr Pro Thr Thr Leu
             125                 130                 135

 ggg aaa gac agg gag tgt cag agc cag agt ctg gca ctc aag gag cag      542
 Gly Lys Asp Arg Glu Cys Gln Ser Gln Ser Leu Ala Leu Lys Glu Gln
         140                 145                 150

 aat aac ttg aag cag ttg gaa ttt ggc ctc aag gaa gca cca gtt caa      590
 Asn Asn Leu Lys Gln Leu Glu Phe Gly Leu Lys Glu Ala Pro Val Gln
     155                 160                 165

 gat caa ggc tac aaa act ctc aga ctc agg gaa aac tgc gtc ctg agt      638
 Asp Gln Gly Tyr Lys Thr Leu Arg Leu Arg Glu Asn Cys Val Leu Ser
 170                 175                 180                 185

 tca agc cca aat cca ttc cca gag atc tct aga ggg gag tat ttg tat      686
 Ser Ser Pro Asn Pro Phe Pro Glu Ile Ser Arg Gly Glu Tyr Leu Tyr
                 190                 195                 200

 act tac gac tca cag att aca gac tca gaa cat aac tcc agc tta gtc      734
 Thr Tyr Asp Ser Gln Ile Thr Asp Ser Glu His Asn Ser Ser Leu Val
             205                 210                 215

 agt cag cag aca ggc tcc cca gga aaa cag ccc ggt gaa aac agt gac      782
 Ser Gln Gln Thr Gly Ser Pro Gly Lys Gln Pro Gly Glu Asn Ser Asp
         220                 225                 230

 tgt cac aga gat tcc agt cag gcc att cca att acg gaa ctc aca aaa      830
 Cys His Arg Asp Ser Ser Gln Ala Ile Pro Ile Thr Glu Leu Thr Lys
     235                 240                 245

 agc cag gtg cag gac aaa ccc tac aaa tgt act gac tgt ggg aag tcg      878
 Ser Gln Val Gln Asp Lys Pro Tyr Lys Cys Thr Asp Cys Gly Lys Ser
 250                 255                 260                 265

 ttt aac cat aac gca cac ctc acc gtg cac aag agg att cat acg gga      926
 Phe Asn His Asn Ala His Leu Thr Val His Lys Arg Ile His Thr Gly
                 270                 275                 280

 gaa aga cct tat atg tgc aag gag tgt ggg aaa gcc ttc agc cag aac      974
 Glu Arg Pro Tyr Met Cys Lys Glu Cys Gly Lys Ala Phe Ser Gln Asn
             285                 290                 295

 tcc tcc ctc gtc cag cat gag cgc atc cac act gga gac aag ccc tac     1022
 Ser Ser Leu Val Gln His Glu Arg Ile His Thr Gly Asp Lys Pro Tyr
         300                 305                 310

 aag tgt gcc gaa tgt ggg aag tct ttc tgc cat agt aca cac ctt acc     1070
 Lys Cys Ala Glu Cys Gly Lys Ser Phe Cys His Ser Thr His Leu Thr
     315                 320                 325

 gtc cat cgg agg att cac act ggg gag aag ccc tat gag tgt cag gac     1118
 Val His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gln Asp
 330                 335                 340                 345

 tgt ggg agg gcc ttc aac cag aac tcc tcc ctg ggg cgg cac aag agg     1166
 Cys Gly Arg Ala Phe Asn Gln Asn Ser Ser Leu Gly Arg His Lys Arg
                 350                 355                 360

 aca cac act ggg gag aag cca tac acc tgc agt gtg tgt ggg aaa tcc     1214
 Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Ser Val Cys Gly Lys Ser
             365                 370                 375

 ttc tct cgg acc act tgc ctt ttc ctg cac ctg aga act cac acc gag     1262
 Phe Ser Arg Thr Thr Cys Leu Phe Leu His Leu Arg Thr His Thr Glu
         380                 385                 390

 gag agg ccc tac gag tgt aac cac tgc ggg aag ggc ttc agg cac agc     1310
 Glu Arg Pro Tyr Glu Cys Asn His Cys Gly Lys Gly Phe Arg His Ser
     395                 400                 405

 tca tcc ctg gcc cag cac cag cgg aag cac gcg ggg gag aag ccc ttt     1358
 Ser Ser Leu Ala Gln His Gln Arg Lys His Ala Gly Glu Lys Pro Phe
 410                 415                 420                 425

 gag tgc cgc cag agg ctg atc ttt gag cag acg cca gct ctc aca aag     1406
 Glu Cys Arg Gln Arg Leu Ile Phe Glu Gln Thr Pro Ala Leu Thr Lys
                 430                 435                 440

 cat gaa tgg aca gaa gcc ctg ggc tgt gac cca cct ttg agt caa gat     1454
 His Glu Trp Thr Glu Ala Leu Gly Cys Asp Pro Pro Leu Ser Gln Asp
             445                 450                 455

 gag agg act cac cga agc gac aga ccc ttc aaa tgt aat cag tgt ggg     1502
 Glu Arg Thr His Arg Ser Asp Arg Pro Phe Lys Cys Asn Gln Cys Gly
         460                 465                 470

 aag tgt ttc att cag agc tct cac ctc atc cgg cac cag ata act cac     1550
 Lys Cys Phe Ile Gln Ser Ser His Leu Ile Arg His Gln Ile Thr His
     475                 480                 485

 acc aga gag gag cag ccc cat ggg cga agc cgg cgg cgt gaa caa tcc     1598
 Thr Arg Glu Glu Gln Pro His Gly Arg Ser Arg Arg Arg Glu Gln Ser
 490                 495                 500                 505

 tcg agc agg aac tca cac ctg gtt cag cat caa cac ccg aac tcc aga     1646
 Ser Ser Arg Asn Ser His Leu Val Gln His Gln His Pro Asn Ser Arg
                 510                 515                 520

 aag agc tct gca ggc gga gca aag gca ggg cag ccg gaa agc aga gcc     1694
 Lys Ser Ser Ala Gly Gly Ala Lys Ala Gly Gln Pro Glu Ser Arg Ala
             525                 530                 535

 ctg gct ttg ttt gac atc caa aaa atc atg caa gag aaa aac cct gtg     1742
 Leu Ala Leu Phe Asp Ile Gln Lys Ile Met Gln Glu Lys Asn Pro Val
         540                 545                 550

 cac gtt att ggg gtg gaa gag cct tct gtg ggt gct tcc atg tta ttt     1790
 His Val Ile Gly Val Glu Glu Pro Ser Val Gly Ala Ser Met Leu Phe
     555                 560                 565

 gac atc aga gaa tcc aca taggag agaaactttg ctgatgactt ttaaccacaa     1844
 Asp Ile Arg Glu Ser Thr 
 570                 575

 gtaaaaaatg tggtaagtcc acatagtgta ctcatggaag gaggggctgg gggtagaaat   1904

 gtcatgggtg acttctgact ttctaaggaa atgatgcttc ccaagcaccc gaggttggtt   1964

 ggtcccaaat ctatcaaact cagtgccctc tttagcgaca tattttgtga cattccttcc   2024

 attacaccac agtgagttca caggtaatat aacctaccca cctgtgtaat gtcaaaaaaa   2084

 atcaatatgc ggccccattt tgtaaaggat cattaaaatg aaagtaattt atggtagagt   2144

 aaaaaaaaaa aa                                                       2156




      <210> 13
      <211> 5745
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (92)..(1543)

      <400> 13
 gcttccccgt gtccctcaga ttgcaaaggc tttctgtgat gatgcagtgg gactgagatt     60

 caatcctgtc ctgtacccca aggcctccca a   atg att gtg tcc tat gat gag     112
                                      Met Ile Val Ser Tyr Asp Glu
                                        1               5

 cat gaa gtc aac aac aca ttc aaa ttc gga gtc att tat caa aaa gcc      160
 His Glu Val Asn Asn Thr Phe Lys Phe Gly Val Ile Tyr Gln Lys Ala
          10                  15                  20

 agg cag acc ctg gag gag gag cta ttt ggg aac aat gag gag agc cca      208
 Arg Gln Thr Leu Glu Glu Glu Leu Phe Gly Asn Asn Glu Glu Ser Pro
      25                  30                  35

 gct ttt aag gag ttc ttg gac ctg ctg ggg gac acg atc aca ctg cag      256
 Ala Phe Lys Glu Phe Leu Asp Leu Leu Gly Asp Thr Ile Thr Leu Gln
  40                  45                  50                  55

 gat ttc aaa ggt ttc cga gga ggc ctg gac gtg acc cac gga cag aca      304
 Asp Phe Lys Gly Phe Arg Gly Gly Leu Asp Val Thr His Gly Gln Thr
                  60                  65                  70

 ggg gtg gaa tca gtg tac aca aca ttc cgg gac agg gag atc atg ttt      352
 Gly Val Glu Ser Val Tyr Thr Thr Phe Arg Asp Arg Glu Ile Met Phe
              75                  80                  85

 cac gtt tcc aca aag ctg cca ttt acc gac gga gac gcc cag cag ctc      400
 His Val Ser Thr Lys Leu Pro Phe Thr Asp Gly Asp Ala Gln Gln Leu
          90                  95                 100

 cag aga aag aga cac att gga aat gac atc gtg gcc atc atc ttc caa      448
 Gln Arg Lys Arg His Ile Gly Asn Asp Ile Val Ala Ile Ile Phe Gln
     105                 110                 115

 gag gaa aac acg ccg ttt gtc cca gac atg ata gcc tcc aat ttc tta      496
 Glu Glu Asn Thr Pro Phe Val Pro Asp Met Ile Ala Ser Asn Phe Leu
 120                 125                 130                 135

 cat gcc tac atc gtc gtg cag gtc gag acc cca ggc aca gag acc cca      544
 His Ala Tyr Ile Val Val Gln Val Glu Thr Pro Gly Thr Glu Thr Pro
                 140                 145                 150

 tcc tac aag gtc tct gtc act gcg cgg gaa gat gtg ccc acc ttt ggt      592
 Ser Tyr Lys Val Ser Val Thr Ala Arg Glu Asp Val Pro Thr Phe Gly
             155                 160                 165

 cca cct ctg ccc agt ccc ccc gtt ttc cag aag ggc ccg gaa ttc agg      640
 Pro Pro Leu Pro Ser Pro Pro Val Phe Gln Lys Gly Pro Glu Phe Arg
         170                 175                 180

 gag ttt ctg ctc acc aag ctc acc aat gcc gag aac gcc tgc tgc aag      688
 Glu Phe Leu Leu Thr Lys Leu Thr Asn Ala Glu Asn Ala Cys Cys Lys
     185                 190                 195

 tcg gac aag ttt gca aag ctg gag gac cgg acc agg gct gcc ctc ctg      736
 Ser Asp Lys Phe Ala Lys Leu Glu Asp Arg Thr Arg Ala Ala Leu Leu
 200                 205                 210                 215

 gac aac ctt cac gat gag ctc cac gcc cac aca cag gcc atg ctg gga      784
 Asp Asn Leu His Asp Glu Leu His Ala His Thr Gln Ala Met Leu Gly
                 220                 225                 230

 ctg ggc cca gag gag gac aag ttt gag aat gga ggc cac ggg ggg ttc      832
 Leu Gly Pro Glu Glu Asp Lys Phe Glu Asn Gly Gly His Gly Gly Phe
             235                 240                 245

 ctg gag tct ttt aag agg gcc atc cgc gta cgc agc cac tcc atg gag      880
 Leu Glu Ser Phe Lys Arg Ala Ile Arg Val Arg Ser His Ser Met Glu
         250                 255                 260

 acc atg gtg ggc ggc cag aag aag tcg cac agt ggg ggc atc cct ggc      928
 Thr Met Val Gly Gly Gln Lys Lys Ser His Ser Gly Gly Ile Pro Gly
     265                 270                 275

 agc ctc agc ggg ggc atc tcc cac aac agc atg gag gtc acc aag acc      976
 Ser Leu Ser Gly Gly Ile Ser His Asn Ser Met Glu Val Thr Lys Thr
 280                 285                 290                 295

 acc ttc tcg cct cca gtg gtg gcg gca acg gtg aag aac cag tca cgg     1024
 Thr Phe Ser Pro Pro Val Val Ala Ala Thr Val Lys Asn Gln Ser Arg
                 300                 305                 310

 agt ccc atc aag cga cgc tcg ggg ctc ttc ccc cgc ctg cac acg ggc     1072
 Ser Pro Ile Lys Arg Arg Ser Gly Leu Phe Pro Arg Leu His Thr Gly
             315                 320                 325

 tca gaa ggc cag ggc gac agc cgg gca cga tgt gac agc aca tcc agc     1120
 Ser Glu Gly Gln Gly Asp Ser Arg Ala Arg Cys Asp Ser Thr Ser Ser
         330                 335                 340

 aca ccc aag acc cca gat ggt gga cac tcc tct cag gag ata aag tct     1168
 Thr Pro Lys Thr Pro Asp Gly Gly His Ser Ser Gln Glu Ile Lys Ser
     345                 350                 355

 gag acc tca tcc aat ccc agc tct cca gaa atc tgc ccc aac aag gag     1216
 Glu Thr Ser Ser Asn Pro Ser Ser Pro Glu Ile Cys Pro Asn Lys Glu
 360                 365                 370                 375

 aag ccc ttc atg aag ttg aag gaa aac ggc cgc gcc atc tcc cgc tcc     1264
 Lys Pro Phe Met Lys Leu Lys Glu Asn Gly Arg Ala Ile Ser Arg Ser
                 380                 385                 390

 tcc tcc agc acc agc agc gtc agc agc act gca ggg gag ggc gag gcc     1312
 Ser Ser Ser Thr Ser Ser Val Ser Ser Thr Ala Gly Glu Gly Glu Ala
             395                 400                 405

 atg gag gag ggc gac agt ggg ggc agc cag ccg tcc acg acc tca ccc     1360
 Met Glu Glu Gly Asp Ser Gly Gly Ser Gln Pro Ser Thr Thr Ser Pro
         410                 415                 420

 ttc aag cag gag gtg ttt gtc tac agc ccg tcc ccg agc agc gag agc     1408
 Phe Lys Gln Glu Val Phe Val Tyr Ser Pro Ser Pro Ser Ser Glu Ser
     425                 430                 435

 ccc agc ctg ggg gca gct gcc acc cca atc atc atg agc cgg agt ccc     1456
 Pro Ser Leu Gly Ala Ala Ala Thr Pro Ile Ile Met Ser Arg Ser Pro
 440                 445                 450                 455

 aca gat gcc aaa agc aga aac tcc ccg aga tcg aac ctg aaa ttc cgc     1504
 Thr Asp Ala Lys Ser Arg Asn Ser Pro Arg Ser Asn Leu Lys Phe Arg
                 460                 465                 470

 ttt gac aag ctc agc cat gcc agc tct ggt gcg ggt cac taatgtgaaa      1553
 Phe Asp Lys Leu Ser His Ala Ser Ser Gly Ala Gly His 
             475                 480

 gtggagtcct tcgcctgtcc aagggaatcc cctcttctgt cctggaaaag gctcctgacc   1613

 tcccagtgtg atgtccgggt cctttatcat cctattcatc ctggagagga aaagtgtcgg   1673

 gcaaaggggg atctgggggg agctcagcag tgactgggga gctggtctgc ctcagagaca   1733

 gagtaggggg tgggagcaga gcctcggtga gggtcttggc cacagggcag tgccttcctg   1793

 aacgtggcag gctttactac caggaacgca ctcggtggtg gaggccccat gttcccagga   1853

 gccaagattc gtagcatcct tgaggccatc ctgataaaat tcggcgctat tgcccccgta   1913

 gctctggagc tctaaaccgt ctatctgctt ctgtgctgaa cgcctttccc atctgctgac   1973

 gtaggcccag ggctgccctg cccctgctgc cagtgtaccg tgagcggggc tccagccagt   2033

 tcaagctcag agccagagct ggacgggcca gaactgcgct gcacacttcc tggactgagg   2093

 cggggacttt gggtcccacc cggtttctcc tgattatggc tgctgtgggg tgaggggagg   2153

 gaggggcagc cccgaggcag tctcttccct ttgagaagat attttcccac aaaggggtgg   2213

 gaagccagga gtgagaagga attcagggag agcaaaggag ccagtgctga gatgctgctg   2273

 tgttggttga ggaaaacctc gggcctgagg gccaggccgg agcccaggtc tctgctgaca   2333

 atgggggttc aaggaagacg tcgttatctc ccctccccac ttactcgagg agagaggtga   2393

 gggggggatg acttgcgggt tctgatcagg cccctgggtg gggaaggggc acagtgtccc   2453

 tcagcagctt acgcccctgg agtcttgggg ggcccagcct ggccctgggg ccttttccag   2513

 ctactgtgcc cttgggcagc tgcgtctggg gctcaacccc ccaatcctgt tcccctctcc   2573

 agctgcgggt ctgtaggcag ctgtcacatc tgaagggttt ctgcaacctg gaccccatct   2633

 gggtgtgggt cagaccctgt gacccacatg ccacccccac cctccacaga gcccccttgc   2693

 tgggacagcc agctcacctc caaggacatc ccctcctggc ttctccccct tccgagtctg   2753

 cagcgccgtg ggcttctctg ccgatgggcc cgggttgggg ttaaggtggg catcctccag   2813

 gtacaacgag cctgaagagc ccctttcagt gcagacgggg ctgcagagtg acactggctg   2873

 ggcacctgcc ccacgaccaa tgacaaggat ttccagctga atgctttatt cccataggga   2933

 tctggacctg tgcccaagat ataaatacta cacttttttt tttttttttt ttttaactga   2993

 cattgtgaaa ttctccctat agcttttgcc attcaagcaa cattgtgatc tttcttcccc   3053

 gccacgtgtg tgggaatgat tgagtcctgt ttgcaagctg gagaggagct ctcccttcgc   3113

 tagtactttc tctaaagtac tagtctagta aaatttattc ttgttagaag gtcaacaaaa   3173

 tatctgttta gcttttatga agagtcaccg tagcagcccc cacggctgga aagaggcccg   3233

 tacgttctgg acgcgttttg ttggctgggc ttctggaggc actggcaagg tcaaactgca   3293

 tttctttaag aacagttgca ggatctggct tgcctctgtg ggaagccggc attacaggtg   3353

 cttggtggat gggccgtgtc acattgccat ctggggtcct ttggggtttc caggttgtca   3413

 gcatgctgtc ccatttggga atcccatacc tgcctgtccc cactgcgctg gctgaccctt   3473

 gctgcctgct gcctcttggg agggctttgt ccctgcctct gagctggtgg gcaggatggc   3533

 tgggtggccc ccagagaagc acagacctgg gatggggtct ccatgcccgg tttgctgttg   3593

 gaatgatctg aacaggaccc caaatgcctc ttccctctgg tcatgcctca ctatctctag   3653

 gagctccatc ctgtggcttc cagagtgtgc acttccagcc cacccgggca gtgctgagag   3713

 ggaggaggag aacaaggatg gcccagcctc ccctccctcc cctagaccac ggggcgggca   3773

 gctcgggttc ctggagggct gtttccccca cgctgtccct acatctgctc tgatctaaaa   3833

 tgtctttcct tttatgctgc gcccagtctt ggggctcaaa gatttgccca aacctcattg   3893

 gccctcgtga ctaggctcat ctagatggtg ctcacgctgg tgtttgaggc atttccactg   3953

 tgatctccac gaggggatgt tttccgggac acatctctgg ctctgggaac tgcctgactc   4013

 actgaagaaa ctacttttca ggcactgtag ggtcacccat atgcctccag ctcagttgac   4073

 gcttaaaaac aggtgcagaa aagctcgcga tggaaggtct taatgagagt gtctgtctat   4133

 gccagtcatg taaaatgacg tttcttgaaa aagattcagt ggttcagctt tgtcagcatc   4193

 atctcaacac aagcctgctg gctcttttta gcatctcatc caaccatgtc atcgtccaga   4253

 tgagaaatct tagcccaggt gaggggaata acttgcttga ggtcacacag ctggctgttg   4313

 gcaaagctgg gattagaacc ctcaacccag ggtcccttcc tctgcagcgc ctacatggtt   4373

 ggttgaataa gtggctgcgt ttcctggggc cctgggtttt ggggaagcca gttagctgct   4433

 gctttggcac tggcatggag gtgagcagtc aaggatgctg gtgaggccgc agtttctgct   4493

 ctttttcatc aggggggata gtctctagga tttttcagtg aggacccttg ggctttggat   4553

 gcagcttgaa ccaagaaaac gaggagggaa agggattcag tgaactattc ctcagtggga   4613

 tcggttcttc agctcctgat gggggctgtg taatgggggc agaggccagg gaaaaagatg   4673

 ctgttcaccc accctcagct tcccttttcc taaattaaga ggaaaagtgg tcaaagaaaa   4733

 actcttcatt tctccctgat tcttaaacga aggtggttaa tagaaactca ggctcccgtg   4793

 acaaggcagg acaagagcct gtttcgcttt cctccctgac cctgccaggt gccaactcaa   4853

 acactacctt tctcattggt ttctaagtca gtagagacag atctgtttta agcagttggg   4913

 ggttcgagta gatctcatgg gtacaggagg ccagcaggga ccaggccagt cagccatgct   4973

 caggacccct cggctcctcc cccagcctct agctaccctg tatcgaggca aggggaggcc   5033

 agtaaagttt gccaagcctg atcctgcagc ctggtggggc tggctggggt attcttttac   5093

 caaactctgt tttaccgcca gccccttgta caccccaatc ccatgtctcc ctcccttcag   5153

 ctggaccgtg tgcccctttg ggaggaagaa gacaagcccc actagggcca agggcagcag   5213

 agccctgccg agtgagaggc tgtggggcag cggctctgtc ctgtgcctta ccagccctgg   5273

 ggagggggac atttggctgg aagactggaa tttaattgcc atcgtctttg attttgtgac   5333

 atttctgctt ggaagtgtga actaccctcc cccccccggc ttcctgctcc ttagcatgcg   5393

 tgcagctctc tcctgttttg ggtgttcccc ttggacactc cagctcgggg actgctggcg   5453

 tgtgaatgtg cagattcccc tgtgtggtcg aacctaagaa ctgtggcttg gaagtgatgc   5513

 tccatgtgac gacgactttg ctttctttcc tcttagtgag gaggtgattc gtagatccca   5573

 actgcctatg taatgtaaat aatgtacatt taatttattg ctatggtagc acattgtatt   5633

 tgttaatgta caaaacaaat tctaaaaggt tgacaaatgt atattttgtt gcttaaatgt   5693

 gtctttgcaa aaattgccaa taaataacat attttgtgtc caaaaaaaaa aa           5745




      <210> 14
      <211> 1476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(1171)

      <400> 14
 cctccccagc cgaggttctc ggcaccgcct tgagagcttc agctgcccca gggtgtgcag     60

 attagaatcc caagaaaatc aa atg gca tcc ggg gat ttc tgc tca cct gga     112
                          Met Ala Ser Gly Asp Phe Cys Ser Pro Gly
                            1               5                  10

 gaa ggg atg gaa ata ctt caa caa gtg tgc agc aaa caa ctt cct cct      160
 Glu Gly Met Glu Ile Leu Gln Gln Val Cys Ser Lys Gln Leu Pro Pro
                  15                  20                  25

 tgt aac ctg agt aaa gag gac ctg tta cag aac cca tac ttc agc aag      208
 Cys Asn Leu Ser Lys Glu Asp Leu Leu Gln Asn Pro Tyr Phe Ser Lys
              30                  35                  40

 ctt ctc ctg aat ctc tca cag cat gtg gat gag agt ggc tta agc ctc      256
 Leu Leu Leu Asn Leu Ser Gln His Val Asp Glu Ser Gly Leu Ser Leu
          45                  50                  55

 acc cta gca aag gag cag gct cag gca tgg aag gaa gtt cga ctg cat      304
 Thr Leu Ala Lys Glu Gln Ala Gln Ala Trp Lys Glu Val Arg Leu His
      60                  65                  70

 aag aca aca tgg ttg agg tct gag att tta cac aga gtc att caa gag      352
 Lys Thr Thr Trp Leu Arg Ser Glu Ile Leu His Arg Val Ile Gln Glu
  75                  80                  85                  90

 ttg ctt gtg gac tac tat gtg aag ata caa gac aca aat gta act tct      400
 Leu Leu Val Asp Tyr Tyr Val Lys Ile Gln Asp Thr Asn Val Thr Ser
                  95                 100                 105

 gag gac aaa aag ttt cat gag acc ctt gaa cag cgg ctg ctt gta act      448
 Glu Asp Lys Lys Phe His Glu Thr Leu Glu Gln Arg Leu Leu Val Thr
             110                 115                 120

 gaa ctg atg cgg ctc tta ggt cct agc cag gag agg gag ata cct cca      496
 Glu Leu Met Arg Leu Leu Gly Pro Ser Gln Glu Arg Glu Ile Pro Pro
         125                 130                 135

 ctg ctg ggg ctg gag aaa gcg gac ctt ctg gaa ctc atg cca ctc tca      544
 Leu Leu Gly Leu Glu Lys Ala Asp Leu Leu Glu Leu Met Pro Leu Ser
     140                 145                 150

 gag gat ttt gtg tgg atg agg gct cgg cta cag caa gaa gta gag gag      592
 Glu Asp Phe Val Trp Met Arg Ala Arg Leu Gln Gln Glu Val Glu Glu
 155                 160                 165                 170

 cag ctc aaa aag aaa tgt ttc act ctg ctc tgc tac tat gat ccc aat      640
 Gln Leu Lys Lys Lys Cys Phe Thr Leu Leu Cys Tyr Tyr Asp Pro Asn
                 175                 180                 185

 tca gat gct gac agt gaa acc gtg aag gca gca aag gtg tgg aaa ctc      688
 Ser Asp Ala Asp Ser Glu Thr Val Lys Ala Ala Lys Val Trp Lys Leu
             190                 195                 200

 gca gag gtc ctg gtg ggt gag cag cag cag tgc cag gat gcc aag agc      736
 Ala Glu Val Leu Val Gly Glu Gln Gln Gln Cys Gln Asp Ala Lys Ser
         205                 210                 215

 cag cag aag gag cag atg ttg ctg ctg gag aag aag agt gct gct tac      784
 Gln Gln Lys Glu Gln Met Leu Leu Leu Glu Lys Lys Ser Ala Ala Tyr
     220                 225                 230

 tcc cag gtg ctt ctc cgc tgc ctc act ttg ctg cag agg ctt ctt caa      832
 Ser Gln Val Leu Leu Arg Cys Leu Thr Leu Leu Gln Arg Leu Leu Gln
 235                 240                 245                 250

 gaa cac cgg ctg aag act caa tcc gag cta gac cgc atc aat gcc cag      880
 Glu His Arg Leu Lys Thr Gln Ser Glu Leu Asp Arg Ile Asn Ala Gln
                 255                 260                 265

 tac ctg gaa gtc aag tgc ggt gct atg atc ctt aag ctg agg atg gag      928
 Tyr Leu Glu Val Lys Cys Gly Ala Met Ile Leu Lys Leu Arg Met Glu
             270                 275                 280

 gag cta aag att ttg tcc gac act tac act gtt gag aaa gtg gaa gtt      976
 Glu Leu Lys Ile Leu Ser Asp Thr Tyr Thr Val Glu Lys Val Glu Val
         285                 290                 295

 cat cgt ctg att agg gac cgt ttg gag gga gcc att cac cta cag gag     1024
 His Arg Leu Ile Arg Asp Arg Leu Glu Gly Ala Ile His Leu Gln Glu
     300                 305                 310

 cag gac atg gag aac tca aga cag gtc ctg aac tcc tat gag gtc ctt     1072
 Gln Asp Met Glu Asn Ser Arg Gln Val Leu Asn Ser Tyr Glu Val Leu
 315                 320                 325                 330

 ggg gag gag ttt gac agg ctg gtg aaa gag tac acc gta ctc aag cag     1120
 Gly Glu Glu Phe Asp Arg Leu Val Lys Glu Tyr Thr Val Leu Lys Gln
                 335                 340                 345

 gca aca gag aac aag cgg tgg gcc ctc cag gag ttc agc aag gtc tac     1168
 Ala Thr Glu Asn Lys Arg Trp Ala Leu Gln Glu Phe Ser Lys Val Tyr
             350                 355                 360

 cgt tgag ctctggcagg gccaggagac atggcttctg catagctgct gcctcctaat     1225
 Arg 


 cttcctgcta gtgggaccac cttcacctgg ggctgccttc agtacaaggg agtgtggaaa   1285

 tgcttacgct tgaaacactg cagtcattta ggcactctcc tggtttctct ttatttttta   1345

 tgactgggcc tcttctggaa aatctagcaa ggagatttat ataattttta tgcatagctg   1405

 tgtgtcagtg tcagccctgt attgtatttg attatctcct gaataaagtt atgatattat   1465

 aaaaaaaaaa a                                                        1476




      <210> 15
      <211> 384
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(306)

      <400> 15
 aaaagaccta gtgtgccaaa a  atg aat gtc aag gtg ggc agg tgg agt cag      51
                          Met Asn Val Lys Val Gly Arg Trp Ser Gln
                            1               5                  10

 gta gtt ttt agg cca ttt att tgt aaa cag tta ttt tat cta tgc gtc       99
 Val Val Phe Arg Pro Phe Ile Cys Lys Gln Leu Phe Tyr Leu Cys Val
                  15                  20                  25

 tat ctg tct gtc tgt ctg tct atc tat cta tct atc tat cta tct atc      147
 Tyr Leu Ser Val Cys Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Ser Ile
              30                  35                  40

 tat cta tct atc tat cta tct atc tat cta tct atc tat cta ttt tat      195
 Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Phe Tyr
          45                  50                  55

 ttt ttg aga tgg agt ctt gct cta tcg tct gag ctg gag tgc agt ggt      243
 Phe Leu Arg Trp Ser Leu Ala Leu Ser Ser Glu Leu Glu Cys Ser Gly
      60                  65                  70

 gtg atc tcg gct cac tgc aaa ctc cgc ctc ccg ggt tca acc aat tct      291
 Val Ile Ser Ala His Cys Lys Leu Arg Leu Pro Gly Ser Thr Asn Ser
  75                  80                  85                  90

 ccc acc tca gcc tcc tgaccagctg ggattacagg cgtgcgccac cacatccagc      346
 Pro Thr Ser Ala Ser 
                  95

 caatgtttgt atttttagta gagacggggc ttcaccat                            384




      <210> 16
      <211> 1644
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(841)

      <400> 16
 ggcggggtct cctgagttgg tggtccttga ccctccatgg gacaaggagc tcgcggctgg     60

 cacagagagc caggccttgg tctccgccac tccccgagaa gactttcggg tgcgctgcac    120

 ctcgaagcgg gctgtgaccg aa atg cta caa ctg tgc ggc cgc ttc gtg caa     172
                          Met Leu Gln Leu Cys Gly Arg Phe Val Gln
                            1               5                  10

 aag ctc ggg gac gct ctg ccg gag gag att cgg gag ccc gct ctg cga      220
 Lys Leu Gly Asp Ala Leu Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg
                  15                  20                  25

 gat gcg cag tgg act ttt gaa tca gct gtg caa gag aat atc agc att      268
 Asp Ala Gln Trp Thr Phe Glu Ser Ala Val Gln Glu Asn Ile Ser Ile
              30                  35                  40

 aat ggg caa gca tgg cag gaa gct tca gat aat tgt ttt atg gat tct      316
 Asn Gly Gln Ala Trp Gln Glu Ala Ser Asp Asn Cys Phe Met Asp Ser
          45                  50                  55

 gac atc aaa gta ctt gaa gat cag ttt gat gaa atc ata gta gat ata      364
 Asp Ile Lys Val Leu Glu Asp Gln Phe Asp Glu Ile Ile Val Asp Ile
      60                  65                  70

 gcc aca aaa cgt aag cag tat ccc aga aag atc ctg gaa tgt gtc atc      412
 Ala Thr Lys Arg Lys Gln Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile
  75                  80                  85                  90

 aaa acc ata aaa gca aaa caa gaa att ctg aag cag tac cac cct gtt      460
 Lys Thr Ile Lys Ala Lys Gln Glu Ile Leu Lys Gln Tyr His Pro Val
                  95                 100                 105

 gta cat cca ctg gac cta aaa tat gac cct gat cca gcc cct cat atg      508
 Val His Pro Leu Asp Leu Lys Tyr Asp Pro Asp Pro Ala Pro His Met
             110                 115                 120

 gaa aat ttg aaa tgc aga ggg gaa aca gta gca aag gag atc agt gaa      556
 Glu Asn Leu Lys Cys Arg Gly Glu Thr Val Ala Lys Glu Ile Ser Glu
         125                 130                 135

 gcc atg aag tcc ttg cct gca tta att gaa caa gga gag gga ttt tcc      604
 Ala Met Lys Ser Leu Pro Ala Leu Ile Glu Gln Gly Glu Gly Phe Ser
     140                 145                 150

 caa gtt ctc agg atg cag cct gtt atc cac ctc cag agg att cac caa      652
 Gln Val Leu Arg Met Gln Pro Val Ile His Leu Gln Arg Ile His Gln
 155                 160                 165                 170

 gaa gtc ttt tcc agt tgt cat agg aaa cca gat gct aaa cct gag aac      700
 Glu Val Phe Ser Ser Cys His Arg Lys Pro Asp Ala Lys Pro Glu Asn
                 175                 180                 185

 ttt ata aca cag ata gaa acc aca cca aca gag act gct tcc agg aaa      748
 Phe Ile Thr Gln Ile Glu Thr Thr Pro Thr Glu Thr Ala Ser Arg Lys
             190                 195                 200

 acc tct gac atg gta ctg aaa aga aag caa act aaa gac tgc ccc cag      796
 Thr Ser Asp Met Val Leu Lys Arg Lys Gln Thr Lys Asp Cys Pro Gln
         205                 210                 215

 aga aaa tgg tat cca ttg cgg cca aag aaa att aat ctt gat aca tga      844
 Arg Lys Trp Tyr Pro Leu Arg Pro Lys Lys Ile Asn Leu Asp Thr 
     220                 225                 230

 gctctttctg tttattttgg gagttgaaaa taggcaccat caacatttag attacagcct    904

 aattaatacc tagataagac ttcatttgaa ataagaaata actcttttac tagtgattca    964

 tttatacaga tatagtatct ctgtgcgggg atatgatata atattgtatt tccttactgt   1024

 tttatctatt gtaaataaaa agcattttaa aaagtattga cacaaagccc atcagtgggc   1084

 attaaaaata ttaaaagtgc agacttttac tgtccttaag tgccatcaac tctcagctcc   1144

 cttgtagctt ttgtgggatt taacaagtaa caaattctgt tgtgtttccc tggtatacat   1204

 ctttctagga aaaaaaaaaa aagagagaga gctgtataat gatttttcgt ttacatgctg   1264

 aaaagtaatt atcagttctg cacagcagca gatgcagggt ttttttttaa agatgtagtt   1324

 tgatttatca aattaatgtg ctgatgataa tactggcttt gactttgtta ctccatgttc   1384

 agctaattta ggtttgtgag attaacttta ggattttttg ttgtgtaaga caatgataac   1444

 tattatttgt gcaacattac tctttgaaat aaaaattggc atgtagccaa tgtttcctgc   1504

 ccacactcac ttttttctat agaccattaa cataatttga cttggaacta atggtttctt   1564

 tttagggttt cttatttatt tctttacaaa tcattccagt tcaaaatata tatcagatta   1624

 atacactgaa aaaaaaaaaa                                               1644




      <210> 17
      <211> 2308
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(788)

      <400> 17
 gcggaggagc agtcgcagct gctttccgag gaagccggtg ttgccgagat tgccaaaatg     60

 ctttggagtt tttaactgaa tctaagaaaa gtccaaaata gatttgagac tgtaaaaaca    120

 gaaactgcag caagggggat tcagtgcca  atg cat caa caa aaa aga caa cca     173
                                  Met His Gln Gln Lys Arg Gln Pro
                                    1               5

 gag tta gtg gaa gga aat ctt cct gtt ttc gtg ttc ccc acg gag ctc      221
 Glu Leu Val Glu Gly Asn Leu Pro Val Phe Val Phe Pro Thr Glu Leu
      10                  15                  20

 ata ttt tat gca gat gat cag tca aca cat aag caa gtg ttg aca ctg      269
 Ile Phe Tyr Ala Asp Asp Gln Ser Thr His Lys Gln Val Leu Thr Leu
  25                  30                  35                  40

 tac aat ccc tat gag ttt gcc tta aag ttc aaa gtt ttg tgt act act      317
 Tyr Asn Pro Tyr Glu Phe Ala Leu Lys Phe Lys Val Leu Cys Thr Thr
                  45                  50                  55

 cca aat aag tat gtt gtc gtt gat gct gca ggt gca gta aag cct cag      365
 Pro Asn Lys Tyr Val Val Val Asp Ala Ala Gly Ala Val Lys Pro Gln
              60                  65                  70

 tgt tgt gtg gat att gtg att cgt cat cga gat gtt cga tcc tgt cac      413
 Cys Cys Val Asp Ile Val Ile Arg His Arg Asp Val Arg Ser Cys His
          75                  80                  85

 tat ggt gta ata gac aaa ttc cgt ctc caa gtt tcc gag caa agc caa      461
 Tyr Gly Val Ile Asp Lys Phe Arg Leu Gln Val Ser Glu Gln Ser Gln
      90                  95                 100

 agg aag gct ttg gga aga aaa gag gtt gtt gct act ctt ctc cca tca      509
 Arg Lys Ala Leu Gly Arg Lys Glu Val Val Ala Thr Leu Leu Pro Ser
 105                 110                 115                 120

 gca aaa gaa caa caa aag gaa gaa gag gaa aaa aga tta aag gaa cat      557
 Ala Lys Glu Gln Gln Lys Glu Glu Glu Glu Lys Arg Leu Lys Glu His
                 125                 130                 135

 tta act gaa agt tta ttt ttt gag cag tcg ttt caa cca gaa aac aga      605
 Leu Thr Glu Ser Leu Phe Phe Glu Gln Ser Phe Gln Pro Glu Asn Arg
             140                 145                 150

 gct gta tcc tca gga cct agt tta cta act gtc ttc ctg gga gtg gtg      653
 Ala Val Ser Ser Gly Pro Ser Leu Leu Thr Val Phe Leu Gly Val Val
         155                 160                 165

 tgc att gca gcc ctg atg ctg cct aca ctg ggg gat gtg gaa tcg ctg      701
 Cys Ile Ala Ala Leu Met Leu Pro Thr Leu Gly Asp Val Glu Ser Leu
     170                 175                 180

 gtg cct ctc tac ctc cac tta agt gtg aat caa aaa tta gtg gct gct      749
 Val Pro Leu Tyr Leu His Leu Ser Val Asn Gln Lys Leu Val Ala Ala
 185                 190                 195                 200

 tat atc tta ggt ctt atc aca atg gcc ata ctt aga aca tgagcaagga       798
 Tyr Ile Leu Gly Leu Ile Thr Met Ala Ile Leu Arg Thr 
                 205                 210

 tttcaattga cttctgaagt aaatctgtct tgaaaatatg aatgtggact gccttttatc    858

 tctatttcac tccattaaca tgcaacaaac tattgaatga tttcaaataa ttgcaaatgt    918

 ataatatata ttttaaatta taatttaatt tgaaggactg cagaacatta ttttacagac    978

 agcaaggatg cttctgagtg acacctagga aattatttga agaaattctt tttatatcta   1038

 tacctgttgt gtaagaaact ttaaaacatt tgttattttc tcaccttttt ttctaattca   1098

 ctttgattgc taggggtcat gtatgcttcg aagttacagg actaaaagag caaactgacc   1158

 ggcctaaaac taaaatgaca tttattccct agctacaaac atcagcgtta ttatgttaat   1218

 tataccttgc cctctatcat tataaatggt tgccatggtg tttctaaaaa taagtgtttt   1278

 accattaatg tgtagagggc aaacaaagca taaagtacta agggatcatg cttatcctag   1338

 ggtctcacag aagagaggac atatttaatt aatcttgtga attacagaac aggttgtggt   1398

 ccagacacca agaatcatag gggttttttt ttaaaaaacc taatagaagt agggtgacct   1458

 ctctctttgg tctaagagtt ctaaaggaag gtaggcatct gtttaattag ttggttcacc   1518

 ctggctttac ctctggttaa tgctttgtgt taataggaag gaaaaatcac tttatctttt   1578

 cttccaagcc cctccctgcc tgacttaccc agactgggat taccagatac caggtgattt   1638

 atgtggagat gatttttcac ctttaaactc taagccaagt gtaagaaact cttgatagct   1698

 atgtctattt tatatcagtc actgagactt ttttttaagt ttttatttat tattaagaca   1758

 actttgccaa aaaagtcccc taagcacaac tatttacatt tctttatagc ctcttctgat   1818

 ctctaacaca tatgcagttt taactgttat tttcatagta actgatcttt tgtctaagga   1878

 tttttacctg aaagcacaat gtattgagtc tcttgaaaat catctttcag atctttttac   1938

 agaatgaact tatgcactgc tactgtagta ttctcaagga atatatgtaa acacaaatgt   1998

 atgcctgagg ttggtttttg cagaaaacag tctctgcttc taaaaacttc tatgtctagt   2058

 cttccatagg aaatcctcac tgtttaacca tgtgaggagc ctaagtcacc taagtcatta   2118

 aacggatcat gtctgtacat tgtgtaatga atgaaaagca cataaatgta atctactttg   2178

 aactttgtaa aaatgatgtg tggaggctat tcttgtttct ccatctcaag tcctgtgtgt   2238

 gcacgtgtgt gcaagtgcac atgtgtgtgt gtaataacac attgtaaaga acagaaatta   2298

 ctttaaaaaa                                                          2308




      <210> 18
      <211> 1833
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1492)

      <400> 18
 gagaaggtcg ctgtcaagat ggagtttcca acccagtaaa tccaagggcc agaccgtgac     60

 ctcataaagc   atg atc tcc ttc tgt cca gac tgt ggc aaa agt atc caa     109
              Met Ile Ser Phe Cys Pro Asp Cys Gly Lys Ser Ile Gln
                1               5                  10

 gcg gca ttc aaa ttc tgc ccc tac tgt gga aat tct ttg cct gta gag      157
 Ala Ala Phe Lys Phe Cys Pro Tyr Cys Gly Asn Ser Leu Pro Val Glu
      15                  20                  25

 gag cat gta ggg tcc cag acc ttt gtc aat cca cat gtg tca tcc ttc      205
 Glu His Val Gly Ser Gln Thr Phe Val Asn Pro His Val Ser Ser Phe
  30                  35                  40                  45

 caa ggc tca aag aga ggg ctg aac tcc agt ttt gaa acc tct cct aag      253
 Gln Gly Ser Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys
                  50                  55                  60

 aaa gtg aaa tgg tcc agc acc gtc acc tct ccc cga tta tcc ctc ttc      301
 Lys Val Lys Trp Ser Ser Thr Val Thr Ser Pro Arg Leu Ser Leu Phe
              65                  70                  75

 tca gat ggt gac agt tct gag tct gaa gat act ctg agt tcc tct gag      349
 Ser Asp Gly Asp Ser Ser Glu Ser Glu Asp Thr Leu Ser Ser Ser Glu
          80                  85                  90

 aga tcc aaa ggc tcc ggg agc aga ccc cca acc ccc aaa agc agc cct      397
 Arg Ser Lys Gly Ser Gly Ser Arg Pro Pro Thr Pro Lys Ser Ser Pro
      95                 100                 105

 cag aag acc agg aag agc cct cag gtg acc agg ggt agc cct cag aag      445
 Gln Lys Thr Arg Lys Ser Pro Gln Val Thr Arg Gly Ser Pro Gln Lys
 110                 115                 120                 125

 acc agc tgt agc cct cag aag acc agg cag agc cct cag acg ctg aag      493
 Thr Ser Cys Ser Pro Gln Lys Thr Arg Gln Ser Pro Gln Thr Leu Lys
                 130                 135                 140

 cgg agc cga gtg acc acc tca ctt gaa gct ttg ccc aca ggg aca gtg      541
 Arg Ser Arg Val Thr Thr Ser Leu Glu Ala Leu Pro Thr Gly Thr Val
             145                 150                 155

 ctg aca gac aag agt ggg cga cag tgg aag ctg aag tcc ttc cag acc      589
 Leu Thr Asp Lys Ser Gly Arg Gln Trp Lys Leu Lys Ser Phe Gln Thr
         160                 165                 170

 agg gac aac cag ggc att ctc tat gaa gct gca ccc acc tcc acc ctc      637
 Arg Asp Asn Gln Gly Ile Leu Tyr Glu Ala Ala Pro Thr Ser Thr Leu
     175                 180                 185

 acc tgt gac tca gga cca cag aag caa aag ttc tca ctc aaa ctg gat      685
 Thr Cys Asp Ser Gly Pro Gln Lys Gln Lys Phe Ser Leu Lys Leu Asp
 190                 195                 200                 205

 gcc aag gat ggg cgc ttg ttc aat gag cag aac ttc ttc cag cgg gcc      733
 Ala Lys Asp Gly Arg Leu Phe Asn Glu Gln Asn Phe Phe Gln Arg Ala
                 210                 215                 220

 gcc aag cct ctg caa gtc aac aag tgg aag aag ctg tac tcg acc cca      781
 Ala Lys Pro Leu Gln Val Asn Lys Trp Lys Lys Leu Tyr Ser Thr Pro
             225                 230                 235

 ctg ctg gcc atc cct acc tgc atg ggt ttc ggt gtt cac cag gac aaa      829
 Leu Leu Ala Ile Pro Thr Cys Met Gly Phe Gly Val His Gln Asp Lys
         240                 245                 250

 tac agg ttc ttg gtg tta ccc agc ctg ggg agg agc ctt cag tcg gcc      877
 Tyr Arg Phe Leu Val Leu Pro Ser Leu Gly Arg Ser Leu Gln Ser Ala
     255                 260                 265

 ctg gat gtc agc cca aag cat gtg ctg tca gag agg tct gtg ctg cag      925
 Leu Asp Val Ser Pro Lys His Val Leu Ser Glu Arg Ser Val Leu Gln
 270                 275                 280                 285

 gtg gcc tgc cgg ctg ctg gat gcc ctg gag ttc ctc cat gag aat gag      973
 Val Ala Cys Arg Leu Leu Asp Ala Leu Glu Phe Leu His Glu Asn Glu
                 290                 295                 300

 tat gtt cat gga aat gtg aca gct gaa aat atc ttt gtg gat cca gag     1021
 Tyr Val His Gly Asn Val Thr Ala Glu Asn Ile Phe Val Asp Pro Glu
             305                 310                 315

 gac cag agt cag gtg act ttg gca ggc tat ggc ttc gcc ttc cgc tat     1069
 Asp Gln Ser Gln Val Thr Leu Ala Gly Tyr Gly Phe Ala Phe Arg Tyr
         320                 325                 330

 tgc cca agt ggc aaa cac gtg gcc tac gtg gaa ggc agc agg agc cct     1117
 Cys Pro Ser Gly Lys His Val Ala Tyr Val Glu Gly Ser Arg Ser Pro
     335                 340                 345

 cac gag ggg gac ctt gag ttc att agc atg gac ctg cac aag gga tgc     1165
 His Glu Gly Asp Leu Glu Phe Ile Ser Met Asp Leu His Lys Gly Cys
 350                 355                 360                 365

 ggg ccc tcc cgc cgc agc gac ctc cag agc ctg ggc tac tgc atg ctg     1213
 Gly Pro Ser Arg Arg Ser Asp Leu Gln Ser Leu Gly Tyr Cys Met Leu
                 370                 375                 380

 aag tgg ctc tac ggg ttt ctg cca tgg aca aat tgc ctt ccc aac act     1261
 Lys Trp Leu Tyr Gly Phe Leu Pro Trp Thr Asn Cys Leu Pro Asn Thr
             385                 390                 395

 gag gac atc atg aag caa aaa cag aag ttt gtt gat aag ccg ggg ccc     1309
 Glu Asp Ile Met Lys Gln Lys Gln Lys Phe Val Asp Lys Pro Gly Pro
         400                 405                 410

 ttc gtg gga ccc tgc ggt cac tgg atc agg ccc tca gag acc ctg cag     1357
 Phe Val Gly Pro Cys Gly His Trp Ile Arg Pro Ser Glu Thr Leu Gln
     415                 420                 425

 aag tac ctg aag gtg gtg atg gcc ctc acg tat gag gag aag ccg ccc     1405
 Lys Tyr Leu Lys Val Val Met Ala Leu Thr Tyr Glu Glu Lys Pro Pro
 430                 435                 440                 445

 tac gcc atg ctg agg aac aac cta gaa gct ttg ctg cag gat ctg cgt     1453
 Tyr Ala Met Leu Arg Asn Asn Leu Glu Ala Leu Leu Gln Asp Leu Arg
                 450                 455                 460

 gtg tct cca tat gac ccc att ggc ctc ccg atg gtg ccc taggtggaat      1502
 Val Ser Pro Tyr Asp Pro Ile Gly Leu Pro Met Val Pro 
             465                 470

 ccagaacttt ccatttgcag tgtgcaacag aaaaaaaaaa atgaagtaat gtgactcaag   1562

 gcctgctgtt taatcacaga taagcttcta gaacaagccc tggaatgtgc attcctgcca   1622

 ctggtttcag gatactcatc agtcctgatt agcctcccgg agggccccag tttccctccc   1682

 gtgaatgtga agttccccat cttggtggcc tgcccttcag ccagtgtcct agcaaagctg   1742

 gatggggttg ggcccggccc acagggggga cccctcctac ccttgacacc tctgtgcttt   1802

 ggtaataaat tgttttacca gaaaaaaaaa a                                  1833




      <210> 19
      <211> 4109
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(1218)

      <400> 19
 gggcgactcc cgctcgtgcc ccggagtcac cgccgtccgc ggatccggcg ctagtagcgg     60

 ggcctgccga ggaagccgag tgcccgccgc cgcgccagcc tcagcccgcg caga  atg     117
                                                              Met
                                                                1

 tgc tcg ctg ccc cgc ggc ttc gag ccc caa gct ccc gag gac ttg gcg      165
 Cys Ser Leu Pro Arg Gly Phe Glu Pro Gln Ala Pro Glu Asp Leu Ala
               5                  10                  15

 cag cgg agt ttg gtg gag ctg cgg gaa atg ttg aag cgc cag gag aga      213
 Gln Arg Ser Leu Val Glu Leu Arg Glu Met Leu Lys Arg Gln Glu Arg
          20                  25                  30

 ctt ttg cgc aac gaa aaa ttc att tgc aaa ttg ccc gac aaa ggt aaa      261
 Leu Leu Arg Asn Glu Lys Phe Ile Cys Lys Leu Pro Asp Lys Gly Lys
      35                  40                  45

 aag atc ttt gac tct ttt gcc aaa ctg aaa gct gcc att gca gaa tgt      309
 Lys Ile Phe Asp Ser Phe Ala Lys Leu Lys Ala Ala Ile Ala Glu Cys
  50                  55                  60                  65

 gaa gaa gtt aga aga aaa agt gaa ctg ttt aac cct gtt agt tta gac      357
 Glu Glu Val Arg Arg Lys Ser Glu Leu Phe Asn Pro Val Ser Leu Asp
                  70                  75                  80

 tgt aag cta agg caa aaa gca att gca gaa gtt gat gtg ggt aca gat      405
 Cys Lys Leu Arg Gln Lys Ala Ile Ala Glu Val Asp Val Gly Thr Asp
              85                  90                  95

 aag gcc cag aat tct gac ccg ata ctt gat act tca tca cta gtt cct      453
 Lys Ala Gln Asn Ser Asp Pro Ile Leu Asp Thr Ser Ser Leu Val Pro
         100                 105                 110

 gga tgt tcc tct gta gat aac atc aag tca tct caa acc tca caa aac      501
 Gly Cys Ser Ser Val Asp Asn Ile Lys Ser Ser Gln Thr Ser Gln Asn
     115                 120                 125

 cag gga ctt gga cgt cct act ctt gaa ggt gat gaa gag act tca gag      549
 Gln Gly Leu Gly Arg Pro Thr Leu Glu Gly Asp Glu Glu Thr Ser Glu
 130                 135                 140                 145

 gtt gag tac aca gtg aat aag ggc cca gct tcc agc aat aga gac agg      597
 Val Glu Tyr Thr Val Asn Lys Gly Pro Ala Ser Ser Asn Arg Asp Arg
                 150                 155                 160

 gta cca cct tca tct gaa gct agt gag cat cac ccg cgg cat cgt gtt      645
 Val Pro Pro Ser Ser Glu Ala Ser Glu His His Pro Arg His Arg Val
             165                 170                 175

 tca agt caa gcg gaa gat act tcc agc agc ttt gac aac ctg ttt att      693
 Ser Ser Gln Ala Glu Asp Thr Ser Ser Ser Phe Asp Asn Leu Phe Ile
         180                 185                 190

 gac agg tta cag agg atc acc att gcg gac caa ggt gaa caa cag tca      741
 Asp Arg Leu Gln Arg Ile Thr Ile Ala Asp Gln Gly Glu Gln Gln Ser
     195                 200                 205

 gaa gaa aac gca agt act aag aac ttg aca ggc ctt tcc agt ggg act      789
 Glu Glu Asn Ala Ser Thr Lys Asn Leu Thr Gly Leu Ser Ser Gly Thr
 210                 215                 220                 225

 gag aag aaa cct cat tac atg gaa gtg cta gaa atg cga gcc aaa aac      837
 Glu Lys Lys Pro His Tyr Met Glu Val Leu Glu Met Arg Ala Lys Asn
                 230                 235                 240

 cca gtg ccc cag ctg cgt aaa ttt aaa acc aat gtg tta cct ttt cga      885
 Pro Val Pro Gln Leu Arg Lys Phe Lys Thr Asn Val Leu Pro Phe Arg
             245                 250                 255

 caa aat gat tca tct agt cat tgc cag aag agt ggg tct cct att tcc      933
 Gln Asn Asp Ser Ser Ser His Cys Gln Lys Ser Gly Ser Pro Ile Ser
         260                 265                 270

 tca gaa gag cgg cgg cgc agg gat aag cag cat ctt gat gac atc aca      981
 Ser Glu Glu Arg Arg Arg Arg Asp Lys Gln His Leu Asp Asp Ile Thr
     275                 280                 285

 gca gct cgg ctt cta cca ctt cac cat atg ccc acg cag ctg ctc tcc     1029
 Ala Ala Arg Leu Leu Pro Leu His His Met Pro Thr Gln Leu Leu Ser
 290                 295                 300                 305

 ata gaa gaa tcc ttg gca ctt cag aaa cag cag aaa cag aat tat gag     1077
 Ile Glu Glu Ser Leu Ala Leu Gln Lys Gln Gln Lys Gln Asn Tyr Glu
                 310                 315                 320

 gag atg caa gca aag ctc gca gcg caa aaa tta gct gaa aga ctg aat     1125
 Glu Met Gln Ala Lys Leu Ala Ala Gln Lys Leu Ala Glu Arg Leu Asn
             325                 330                 335

 att aaa atg cgg agt tat aat cca gaa ggg gag tct tca ggg aga tac     1173
 Ile Lys Met Arg Ser Tyr Asn Pro Glu Gly Glu Ser Ser Gly Arg Tyr
         340                 345                 350

 cga gaa gta agg gat gaa gat gac gat tgg tcc tct gat gaa ttc tga     1221
 Arg Glu Val Arg Asp Glu Asp Asp Asp Trp Ser Ser Asp Glu Phe 
     355                 360                 365

 agataatctc ctaaatcact gacgttgaga tgtcatcatc ttacatcaga ctttctaact   1281

 agtatcaaga tcagtgtcag atattgttga gggaagtaat tttataaagt tacacaaagg   1341

 tagttataaa aaaagcccag tttgtctttc agaaggtgac tttcatgtgc ttgaaaagtt   1401

 taatatttga atattgtgtt taaccacatg gtattaaaat tttgcaatat attgtgtatt   1461

 ggtctgatat tttagtatat agtagaacat actttttttt tctttaagcc aaatgaaaag   1521

 aggtaacttt gcttttttcc tttttcttac ctatcaaata gcatttatta catgtctttc   1581

 agtgaaatac ttagttgttc caggcaccta aaatcaatta ggaagacata gttcccttct   1641

 tttttgggta atgaagggag cagtctaaag aattgtatgc atgtttgcat ggggttattg   1701

 agacattgga tgtgaaatac ctaggaagac atgtatggag aatgcttaac aaatgctctt   1761

 ctcctttttc tgtcttccct taggaagaac gttatctctc ttctgattag ggaaggactt   1821

 cccttttgag tagatgctgg aaagtggagg ttttttttgt tggtttgttt gtttggtttt   1881

 gtgttttttt ttgagatggg gtcttgctct gtcgcccagg ctggagtgca gtggcaggat   1941

 ctcggctcac tgcaatctag gtggaggtct ttttaaataa cctcatgtta cttcaggcaa   2001

 atctggtaca ggagaagccc aagctaactg agctgggtga aggcttgtgc atcacctggc   2061

 ttgagttcct tgctgtcaca gatgataggt tcatgtacac aacattaatg tttgataagg   2121

 aaagcatttt ttttttgtta aaattgaatt gtcagtactt tacttttttc cccccaaata   2181

 ggtatatata gactgcagaa gcttcagtcc catatataaa cgttcatgtc attttagagg   2241

 attatatggt tgtctccaga gaaattaact tacattatca aaaaattctt tgtctaatat   2301

 attggagtct ttaaaagtgt tgaagaataa aatattaatt agaacaactt caaatgctaa   2361

 ggtgatgttt taccgggact taattaaata caactttttc ctttcgaaaa agactgttca   2421

 catttgcttc caggtgtaat tattgctttc attccttacc cccctcaagc aaatgtgaaa   2481

 agtatactga cctaagattc tcattagttt tagttcttaa aacgaatagt aaatgatttc   2541

 acagcgtaaa atttgatgtt atttctggaa gctggatgat atggaagagt tcatgtgcct   2601

 ggacacacag ttccctgtaa tcctgccatc tagggagata aactctgtta acattttgat   2661

 gttgtgtttt tgcttatttt tctatgcata gttatgcatt tatattctca aaaatgaaat   2721

 cataatgtac attgctttgt agtctgctct atatattgtc aatatgttcc catattaaat   2781

 attttgcttt ttagacagct gtaggatatt ttatttcatg ggtataccat aactttaaga   2841

 tttatttcct attcagcaat ttgattatgt attataatgt aatctgtaaa tagtgatatg   2901

 attaacatct taatcacatc catagaaaat gacttatttc cagaagatac cgctctaaaa   2961

 atgaaattgt taggtgaaag tgtttttgag aatttttata tatattactc actgcagaga   3021

 tcatgttcat ttacattccc attagcaata tatccaatgc tcagaattga aaattactac   3081

 ttaaaatctt tgcaaattga ataattacag aaaagggcta catttaaaat ttgtatttgt   3141

 ttttcttact tagtgaaggt tgtgtttttt ttcatattca ttggccatgc tatattcatt   3201

 cttttgagaa ttgctcattc atattttttc tgttgcttgc ttggagaatt tgctcttttt   3261

 ttggcatata agttcttaag aatgtccgtc ctttgtcata tattgtaact ttttttagcc   3321

 ttatttgtca tttaacatag tttgtggtat ttcagtatag aagttgtttt ctttaggagt   3381

 ctacctttgt gtatgtgctt gaaagtattt ttgtaatcca agaatggata aatgtcctta   3441

 ttttcttcta gtattttctt atttcacttt tacacctatc tttaaaagga atttaaattt   3501

 tgtttatata cattaactaa atcagtacaa gtttggggtg aaaaggaaat ttttaatcca   3561

 tctcaaatgt atttggttat attatataag gtagggattt gattttattt cgaagaattt   3621

 accaattggt tcagtatgtg aaaccaccat ttcccctctg attagtaatg ctatttttat   3681

 agaatattaa attcttatgt gtcttttgtg tcttaggcca atttctgggc cttctgggtt   3741

 ttttctacac tgtcaataat tatcgcttta attggtgtta atatttggta gtacacaggt   3801

 tctcccttgt tcttttaaat tttgtgaaat ataacttaca aataagtact taaaacagag   3861

 cttaatgggt aaagcaacag ctgtgtaatc acaaactaga tgcagaggag gtcttgccag   3921

 cactccaaaa tctctgtgtg tcccctcttg acactcactg tttcccccag agctaactat   3981

 cctgacgtat ggtaattctc cctctgtcct tttaagaatt attttaccag ttatgtgtat   4041

 aacaatatgg tttacatttt gctcactttt gacttatata aaaatagaat aatactaaaa   4101

 aaaaaaaa                                                            4109




      <210> 20
      <211> 573
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(213)

      <400> 20
 ggctgtgtac caataaaact ttatttatag acactggaat tcgaatctca tatcattttc     60
                                                                 
 atg agt cac aga atc ttc ttc ttt tgc tat tta aaa gca aaa ata aaa      108
 Met Ser His Arg Ile Phe Phe Phe Cys Tyr Leu Lys Ala Lys Ile Lys
   1               5                  10                  15

 att ctt ggc tgg gca cgg tgg ctt gtg cct gta atc cct gca ctt tgg      156
 Ile Leu Gly Trp Ala Arg Trp Leu Val Pro Val Ile Pro Ala Leu Trp
              20                  25                  30

 gag gct gaa gtg gga aga tca ttt gag gcc agg agt tca aga aca gcc      204
 Glu Ala Glu Val Gly Arg Ser Phe Glu Ala Arg Ser Ser Arg Thr Ala
          35                  40                  45

 tgg gca aca tagtgag atcctatttc tacaaaaaat aaaaaataaa ataaaataaa      260
 Trp Ala Thr 
      50

 attcttagtt catggtcaaa aacaggattt gctttgcgga acaccatttg cagtccccta    320

 tgctaaccta tctaggtgct taaaacagta cctaacaccc tgttcttggg ttggctttaa    380

 acaccaacca aggatttaat acctgttagc catttcaggt ggaaagatgt gaatgtggta    440

 tgaagtgggt catctgtggc agttggcttg ttggtgaggg acaggccatt ggtaatggaa    500

 gggtcagctc tgtcttggaa cagctgccca gagcatggcc cgccatgctc cccctcaaca    560

 cccaaagtga cac                                                       573




      <210> 21
      <211> 1358
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (291)..(887)

      <220>
      <221> misc_feature
      <222> (1)...(1358)
      <223> n = a,t,c or g

      <400> 21
 ttagttttga gggannnagg nnatttgatn nccatcgtag accattaggc cagngncgng     60

 gaattcgcct gctgttatcc acataagatg tgacttgctt ctccttgcct tcagtcatga    120

 ttgtgaggct tccccagcca cgtggaacta gggataacca attggctggc aaagtaacaa    180

 atgaaaagta acctgactct attgacctgc ttaaccctgc atggggggga aggatggaaa    240

 ggagcagctg tttgctttga aacggtggaa cagttttgca gccttagaaa   atg gca     296
                                                          Met Ala
                                                            1

 tgt aac ata cct aac caa aga cag cgg act ctg tca aca aca gga gaa      344
 Cys Asn Ile Pro Asn Gln Arg Gln Arg Thr Leu Ser Thr Thr Gly Glu
           5                  10                  15

 gct cta tac gaa att ctt ggt ctg cat aag gga gca tca aat gaa gaa      392
 Ala Leu Tyr Glu Ile Leu Gly Leu His Lys Gly Ala Ser Asn Glu Glu
      20                  25                  30

 att aag aaa acc tac aga aaa ttg gcc ctg aaa cac cat cca gac aag      440
 Ile Lys Lys Thr Tyr Arg Lys Leu Ala Leu Lys His His Pro Asp Lys
  35                  40                  45                  50

 aat cca gat gat cca gct gct act gag aag ttt aaa gaa atc aac aac      488
 Asn Pro Asp Asp Pro Ala Ala Thr Glu Lys Phe Lys Glu Ile Asn Asn
                  55                  60                  65

 gcc cac gca ata ctt acc gac att tca aag aga agc ata tac gac aag      536
 Ala His Ala Ile Leu Thr Asp Ile Ser Lys Arg Ser Ile Tyr Asp Lys
              70                  75                  80

 tac gga tcg ctg gga ctc tac gtg gcc gag cag ttt gga gac gaa aac      584
 Tyr Gly Ser Leu Gly Leu Tyr Val Ala Glu Gln Phe Gly Asp Glu Asn
          85                  90                  95

 gtt aac acc tac ttc atg ctg tcg agc tgg tgg gca aag gcc ctg ttt      632
 Val Asn Thr Tyr Phe Met Leu Ser Ser Trp Trp Ala Lys Ala Leu Phe
     100                 105                 110

 gtc atc gtt ggc ctc ttg acg ggc tgc tac ttt tgc tgc tgc ctg tgc      680
 Val Ile Val Gly Leu Leu Thr Gly Cys Tyr Phe Cys Cys Cys Leu Cys
 115                 120                 125                 130

 tgc tgc tgc aac tgc tgc tgt gga cac tgc cgg ccc gag tca tca gtg      728
 Cys Cys Cys Asn Cys Cys Cys Gly His Cys Arg Pro Glu Ser Ser Val
                 135                 140                 145

 cca gaa gag gac ttc tat gtg tcc cca gag gat ctg gag gag cag atc      776
 Pro Glu Glu Asp Phe Tyr Val Ser Pro Glu Asp Leu Glu Glu Gln Ile
             150                 155                 160

 aag tct gac atg gaa aaa gat gtg gac ttt cca gtt ttt ctc cag cct      824
 Lys Ser Asp Met Glu Lys Asp Val Asp Phe Pro Val Phe Leu Gln Pro
         165                 170                 175

 aca aat gca aat gag aaa aca cag cta atc aaa gaa gga tct cga agt      872
 Thr Asn Ala Asn Glu Lys Thr Gln Leu Ile Lys Glu Gly Ser Arg Ser
     180                 185                 190

 tat tgc aca gac tct tgatattgag ccctcagaga gtccacagtc cctcctctca      927
 Tyr Cys Thr Asp Ser 
 195

 gttcagtctt gtctccagat ggtcgtaggg gagcgtgtgg ggcataaagt gctgtgaact    987

 tttccatctt gttgttttat ttttgggtta ggaaaacatg attgctatat aattttctca   1047

 gtatgcagac tttctctctg agtagaattt cttatgaaac acattcaatt tgggtgaata   1107

 aaggcctgaa gagttatttt accctccttg cctgatgtag gacagtggaa ttgtacagcc   1167

 tttatgaacc tgccctttat gtgtggcaga tctgattcct aactgaccaa agtaatattc   1227

 cagaacaaaa gccacttttc ttacatttaa cacaatattc atatctacca cgaacatgat   1287

 catcaaaata tatgagaact tataaagagt ttttgtgtgt ggagcctctt ccgtgtcaat   1347

 attcaataaa g                                                        1358




      <210> 22
      <211> 2625
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(1526)

      <400> 22
 aggcttgcgg ccgcgggagc tgaccctgcg gggtcccggg gggggagggg gagccgcgaa     60

 gcccccactg aggccgccgc tgccgggcct cccctccccc ccgggcgggc gcc   atg     116
                                                              Met
                                                                1

 cgg ggg agc ccg ggc gac gcg gag cgg cgg cag cgc tgg ggt cgc ctg      164
 Arg Gly Ser Pro Gly Asp Ala Glu Arg Arg Gln Arg Trp Gly Arg Leu
               5                  10                  15

 ttc gag gag ctg gac agt aac aag gat ggc cgc gtg gac gtg cac gag      212
 Phe Glu Glu Leu Asp Ser Asn Lys Asp Gly Arg Val Asp Val His Glu
          20                  25                  30

 ttg cgc cag ggg ctg gcc agg ctg ggc ggg ggc aac cca gac ccc ggc      260
 Leu Arg Gln Gly Leu Ala Arg Leu Gly Gly Gly Asn Pro Asp Pro Gly
      35                  40                  45

 gcc caa cag ggt atc tcc tct gag ggt gat gct gac cca gat ggc ggg      308
 Ala Gln Gln Gly Ile Ser Ser Glu Gly Asp Ala Asp Pro Asp Gly Gly
  50                  55                  60                  65

 ctc gac ctg gag gaa ttt tcc cgc tat ctg cag gag cgg gaa cag cgt      356
 Leu Asp Leu Glu Glu Phe Ser Arg Tyr Leu Gln Glu Arg Glu Gln Arg
                  70                  75                  80

 ctg ctg ctc atg ttt cac agt ctt gac cgg aac cag gat ggt cac att      404
 Leu Leu Leu Met Phe His Ser Leu Asp Arg Asn Gln Asp Gly His Ile
              85                  90                  95

 gat gtc tct gag atc caa cag agt ttc cga gct ctg ggc att tcc atc      452
 Asp Val Ser Glu Ile Gln Gln Ser Phe Arg Ala Leu Gly Ile Ser Ile
         100                 105                 110

 tcg ctg gag cag gct gag aaa att ttg cac agc atg gac cga gac ggc      500
 Ser Leu Glu Gln Ala Glu Lys Ile Leu His Ser Met Asp Arg Asp Gly
     115                 120                 125

 aca atg acc att gac tgg caa gaa tgg cgc gac cac ttc ctg ttg cat      548
 Thr Met Thr Ile Asp Trp Gln Glu Trp Arg Asp His Phe Leu Leu His
 130                 135                 140                 145

 tcg ctg gaa aat gtg gag gac gtg ctg tat ttc tgg aag cat tcc acg      596
 Ser Leu Glu Asn Val Glu Asp Val Leu Tyr Phe Trp Lys His Ser Thr
                 150                 155                 160

 gtc ctg gac att ggc gag tgc ctg aca gtg ccg gac gag ttc tca aag      644
 Val Leu Asp Ile Gly Glu Cys Leu Thr Val Pro Asp Glu Phe Ser Lys
             165                 170                 175

 caa gag aag ctg acg ggc atg tgg tgg aaa cag ctg gtg gcc ggc gca      692
 Gln Glu Lys Leu Thr Gly Met Trp Trp Lys Gln Leu Val Ala Gly Ala
         180                 185                 190

 gtg gca ggt gcc gtg tca cgg aca ggc acg gcc cct ctg gac cgc ctc      740
 Val Ala Gly Ala Val Ser Arg Thr Gly Thr Ala Pro Leu Asp Arg Leu
     195                 200                 205

 aag gtc ttc atg cag gtc cat gcc tca aag acc aac cgg ctg aac atc      788
 Lys Val Phe Met Gln Val His Ala Ser Lys Thr Asn Arg Leu Asn Ile
 210                 215                 220                 225

 ctt ggg ggg ctt cga agc atg gtc ctt gag gga ggc atc cgc tcc ctg      836
 Leu Gly Gly Leu Arg Ser Met Val Leu Glu Gly Gly Ile Arg Ser Leu
                 230                 235                 240

 tgg cgc ggc aat ggt att aat gta ctc aag att gcc ccc gag tca gct      884
 Trp Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala Pro Glu Ser Ala
             245                 250                 255

 atc aag ttc atg gcc tat gaa cag atc aag agg gcc atc ctg ggg cag      932
 Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Ala Ile Leu Gly Gln
         260                 265                 270

 cag gag aca ctg cat gtg cag gag cgc ttc gtg gct ggc tcc ctg gct      980
 Gln Glu Thr Leu His Val Gln Glu Arg Phe Val Ala Gly Ser Leu Ala
     275                 280                 285

 ggt gcc aca gcc caa acc atc att tac cct atg gag gtg ctg aag acg     1028
 Gly Ala Thr Ala Gln Thr Ile Ile Tyr Pro Met Glu Val Leu Lys Thr
 290                 295                 300                 305

 cgg ctg acc ttg cgc cgg acg ggc cag tat aag ggg ctg ctg gac tgc     1076
 Arg Leu Thr Leu Arg Arg Thr Gly Gln Tyr Lys Gly Leu Leu Asp Cys
                 310                 315                 320

 gcc agg cgt atc ctg gag agg gag ggg ccc cgt gcc ttc tac cgc ggc     1124
 Ala Arg Arg Ile Leu Glu Arg Glu Gly Pro Arg Ala Phe Tyr Arg Gly
             325                 330                 335

 tac ctc ccc aac gtg ctg ggc atc atc ccc tat gcg ggc atc gac ctg     1172
 Tyr Leu Pro Asn Val Leu Gly Ile Ile Pro Tyr Ala Gly Ile Asp Leu
         340                 345                 350

 gcc gtc tac gag act ctg aag aac tgg tgg ctt cag cag tac agc cac     1220
 Ala Val Tyr Glu Thr Leu Lys Asn Trp Trp Leu Gln Gln Tyr Ser His
     355                 360                 365

 gac tcg gca gac cca ggc atc ctc gtg ctc ctg gcc tgc ggt acc ata     1268
 Asp Ser Ala Asp Pro Gly Ile Leu Val Leu Leu Ala Cys Gly Thr Ile
 370                 375                 380                 385

 tcc agc acc tgc ggc cag ata gcc agt tac ccg ctg gcc ctg gtc cgg     1316
 Ser Ser Thr Cys Gly Gln Ile Ala Ser Tyr Pro Leu Ala Leu Val Arg
                 390                 395                 400

 acc cgc atg cag gca caa gcc tcc atc gag ggt ggc ccc cag ctg tcc     1364
 Thr Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Gly Pro Gln Leu Ser
             405                 410                 415

 atg ctg ggt ctg cta cgt cac atc ctg tcc cag gag ggc atg cgg ggc     1412
 Met Leu Gly Leu Leu Arg His Ile Leu Ser Gln Glu Gly Met Arg Gly
         420                 425                 430

 ctc tac cgg ggg atc gcc ccc aac ttc atg aag gtt att cca gct gtg     1460
 Leu Tyr Arg Gly Ile Ala Pro Asn Phe Met Lys Val Ile Pro Ala Val
     435                 440                 445

 agc atc tcc tat gtg gtc tac gag aac atg aag cag gcc ttg ggg gtc     1508
 Ser Ile Ser Tyr Val Val Tyr Glu Asn Met Lys Gln Ala Leu Gly Val
 450                 455                 460                 465

 acg tcc aga tcc ttc tgc tgactg ccagatccct gcatttcaag cactacgcct     1562
 Thr Ser Arg Ser Phe Cys 
                 470

 tccaccccca ggcactggat cccagattcc caagccttca cccaccagat tctggctcct   1622

 aaaacaagtg cgggggcccc agtggcacag caagtggatc ctggcaactg cagctgctgg   1682

 attccagatt ctgggtcccc aatccctctg cccagtccct caatgttgaa acctcatctc   1742

 ttgaaggcag atcctgatat tccaaggcac tgaatcccaa gccctgaatc cccggtttct   1802

 gatctgaatc ttccaggcgc cgggtcccaa atgttcaggc cccaagtcta gatcctggca   1862

 gcccagtcac agagtatccc acacacactg gtgcccagag ccggcttctc atgacatgaa   1922

 attgcatggt cgagggagtc tgtggggaag gaagcccagg tcctggctgc aacctgcacg   1982

 gatgctggat tccccctcac cccacctctg catggccacc ccctcccagc cctgtgggga   2042

 aactgttccc tggaaccact ccactccctg catccccaca cttcacagca tcttccatcc   2102

 ccctcccacc ttctaggcga atagtcccca gagctgtgtt cctccaaggg gtccgaggaa   2162

 tcactcactc ctggaggctg gcaaggagac agtctgaggc cagggacaca tgaagggatg   2222

 tccccacccc agcactatca gggcctcccc aggcttccag agttgaaagc caggagaaaa   2282

 tcggcaaaga ccacccttcc ctaaacccaa gcacccaatg atgcaaaaaa caaaaacaaa   2342

 aaaaaaccac caaatcccca aattcattcc agatctattt ttctaccaga gagaggagca   2402

 aagtcctcct cccctgcgcc cttacattct gcacttcata gttggattct gagcttagga   2462

 tcatctggag accccatgga gggacttgga aaggggaact gggatttggg gaggggctgg   2522

 aggacttccg cacgcttcca cctccttcga cctccactgc gccccacctc cctgcctgtg   2582

 tgtgttattt caaaggaaaa gaacaaaagg aataaatttt cta                     2625




      <210> 23
      <211> 1756
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (340)..(831)

      <400> 23
 atttcctgcc tctacccatc aactccttat aaagagcccc atgagctaag actaaggaga     60

 ggatcatgtc ccttgggcgt gtgcccatgt ctgggagaag aaatatacac cactgaacac    120

 cgagcacatg ggagagggaa gggacaccac aggagagaga gaggcagata ccccaagagg    180

 tggatgggcc gagctcccag ccaaccctga aggaggcact gcttccaggg gttcttaaaa    240

 aagaagaaaa tcatacaacc aaagggggag gggacaggta gagggcgagg agttgtccca    300

 tttatacaca acattgtaaa catacacggt ctatattac   atg tgc ttc agt ctg     354
                                              Met Cys Phe Ser Leu
                                                1               5

 gtg ttt gca tgt ctg tct gtc cgt ctg tca gta tgg ggg ctg gat ctt      402
 Val Phe Ala Cys Leu Ser Val Arg Leu Ser Val Trp Gly Leu Asp Leu
                  10                  15                  20

 agg agc cgt gcc cca cta ctc ccc caa ccc cca cct ccc tgc ccc acc      450
 Arg Ser Arg Ala Pro Leu Leu Pro Gln Pro Pro Pro Pro Cys Pro Thr
              25                  30                  35

 ctg gga aca gag ctg gaa cag gta tgg ccc cca aac cat agg tgg gag      498
 Leu Gly Thr Glu Leu Glu Gln Val Trp Pro Pro Asn His Arg Trp Glu
          40                  45                  50

 cca gca ggt agt gcc tgg gcc aca gcc tct act ctg gct cca gag tcc      546
 Pro Ala Gly Ser Ala Trp Ala Thr Ala Ser Thr Leu Ala Pro Glu Ser
      55                  60                  65

 tgc gtg tgt aaa tgt gtg tgt gtg tac gca tgt ttg agt atg tgc atg      594
 Cys Val Cys Lys Cys Val Cys Val Tyr Ala Cys Leu Ser Met Cys Met
  70                  75                  80                  85

 tat gta cat ggg gaa cct gtg tgc aag tat gta caa agg gag acg gtc      642
 Tyr Val His Gly Glu Pro Val Cys Lys Tyr Val Gln Arg Glu Thr Val
                  90                  95                 100

 act gtc aca gag gct ggg ggc agg tgg ggc tgc tgg agg cga ggc ctg      690
 Thr Val Thr Glu Ala Gly Gly Arg Trp Gly Cys Trp Arg Arg Gly Leu
             105                 110                 115

 cct ggg gca gat agc tca caa gta gat cct ccg cag gtc tcc ggg cgc      738
 Pro Gly Ala Asp Ser Ser Gln Val Asp Pro Pro Gln Val Ser Gly Arg
         120                 125                 130

 tgt gat cgt gtt gca ctg agg gca gag ctt ctt ggc acc cag ggt ccg      786
 Cys Asp Arg Val Ala Leu Arg Ala Glu Leu Leu Gly Thr Gln Gly Pro
     135                 140                 145

 cag cca gca ctc ctc gca gtg cac gtg cca aca ctg gat gga cgt tag      834
 Gln Pro Ala Leu Leu Ala Val His Val Pro Thr Leu Asp Gly Arg 
 150                 155                 160

 gggcatcgag tacgagtcca tgcagatgag gcatttgtaa cggtccccac gagatagctg    894

 ccgttcaagt tctctgaccc gagccttcag agcctcaaac gtggtcacag ctgaatcttc    954

 ggtgattttc tcgatgtcgc tgttcttgca ggtcttctgc atggcctcct gcttgctgct   1014

 ttcaccattg ctggtggatg gcatctcatc actggcccat ttagagaact caggtgtgat   1074

 gcgcgtgctg ggagggccgc catttaggac tgcgccccga agtgcctctc tctccttggc   1134

 ttcaccaggc tcctcgcctg tgcaggggat gacatcagcc tctgtgtatt gtggcttccc   1194

 atactccaga gtgtcatccc catccacatc caagtcagca tcactgtccg ggttctcttt   1254

 gccgctgcac atgatgaagc cagagcctcg gaagccacct tccaggagag tggtggcccg   1314

 tatccgcttc tgtccacacc actcatactc ctcaaagcgg ttgttgttct catgctcgat   1374

 gtccacagca tcatcctcag ccatgcagga gccttccctc tgtgaagagc agagcaggat   1434

 catgctgggc ccaggccatc cccacctgct ccccacagtc tgcaacgaag gcacagctct   1494

 agccccagct gtggtgtgcc aagtgggccc tcagctctag ggctcctttg aagcaaacca   1554

 atttagaggt caaagacctg ggcctcttcc caatagtttt ccgctggagc ccaaggaggg   1614

 aatgagtgag agtgaaagca aaaggagaga gcagtggtca gaagggaaga agctgctgag   1674

 accacatgga gaccccaaga gcccacagat tcaggggcag tcagcagcta gtgtcggggg   1734

 aagggagcgg ggaaggaagg tg                                            1756




      <210> 24
      <211> 2313
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(931)

      <400> 24
 gcgcgggatc tcgagctggg atcgccctcc tgggcttcgg tgcgatcggc ggcgggaggt     60

 tccctgggaa ccaggtggtc gaagggctga gctgtgtggc cagacaagag gtccctgccc    120

 tcccccagtg agccctgctg ttcccgtggg agcc    atg aag ctg aac gag agg     172
                                          Met Lys Leu Asn Glu Arg
                                            1               5

 agt gta gcc cac tat gca ctc agc gac tcc cca gcg gac cac atg ggc      220
 Ser Val Ala His Tyr Ala Leu Ser Asp Ser Pro Ala Asp His Met Gly
              10                  15                  20

 ttc ctg cgc acc tgg ggg ggc cca ggg acc cca ccg acc ccc agt ggc      268
 Phe Leu Arg Thr Trp Gly Gly Pro Gly Thr Pro Pro Thr Pro Ser Gly
          25                  30                  35

 act ggc cga aga tgc tgg ttt gtc ctc aag ggc aac ctg cta ttc tcc      316
 Thr Gly Arg Arg Cys Trp Phe Val Leu Lys Gly Asn Leu Leu Phe Ser
      40                  45                  50

 ttt gag agt cgc gag ggc cgg gcc cca ctg agc ctg gtg gtg ctg gaa      364
 Phe Glu Ser Arg Glu Gly Arg Ala Pro Leu Ser Leu Val Val Leu Glu
  55                  60                  65                  70

 ggc tgc aca gtg gaa ctg gcc gag gct ccc gtg ccc gag gag ttt gcc      412
 Gly Cys Thr Val Glu Leu Ala Glu Ala Pro Val Pro Glu Glu Phe Ala
                  75                  80                  85

 ttt gcc atc tgc ttt gat gcc cct gga gtg cgc cca cac ctg ctg gcc      460
 Phe Ala Ile Cys Phe Asp Ala Pro Gly Val Arg Pro His Leu Leu Ala
              90                  95                 100

 gca gaa ggg ccg gcg gcc cag gag gcc tgg gtg aag gtg ctg tcc cgg      508
 Ala Glu Gly Pro Ala Ala Gln Glu Ala Trp Val Lys Val Leu Ser Arg
         105                 110                 115

 gca agc ttt ggc tac atg cgc ctg gtg gta cgc gag ttg gag agc cag      556
 Ala Ser Phe Gly Tyr Met Arg Leu Val Val Arg Glu Leu Glu Ser Gln
     120                 125                 130

 ttg cag gac gca cgc cag agc ctg gct ttg caa cgc cgc tca tcc tgg      604
 Leu Gln Asp Ala Arg Gln Ser Leu Ala Leu Gln Arg Arg Ser Ser Trp
 135                 140                 145                 150

 aag ttt gtt gcc agc cgc tgt aag ccc cag gct cct aac cac cga gct      652
 Lys Phe Val Ala Ser Arg Cys Lys Pro Gln Ala Pro Asn His Arg Ala
                 155                 160                 165

 gcg ggc ctg gag aat ggc cac tgc ctc tcc aag gac agc agc cct gtg      700
 Ala Gly Leu Glu Asn Gly His Cys Leu Ser Lys Asp Ser Ser Pro Val
             170                 175                 180

 ggc ttg gtt gaa gaa ggg ggc agc agg tct gca ggg tgg ggg ttg gct      748
 Gly Leu Val Glu Glu Gly Gly Ser Arg Ser Ala Gly Trp Gly Leu Ala
         185                 190                 195

 gag tgg gag ctg cag ggc cct gcc agc ctc ctc cta ggc aag ggg cag      796
 Glu Trp Glu Leu Gln Gly Pro Ala Ser Leu Leu Leu Gly Lys Gly Gln
     200                 205                 210

 agc cct gtg tcc cct gag acc tcc tgc ttc tct acc ctg cat gac tgg      844
 Ser Pro Val Ser Pro Glu Thr Ser Cys Phe Ser Thr Leu His Asp Trp
 215                 220                 225                 230

 tat ggc cag gag atc gtg gag ctg cgg cag tgt tgg cag aag agg gcc      892
 Tyr Gly Gln Glu Ile Val Glu Leu Arg Gln Cys Trp Gln Lys Arg Ala
                 235                 240                 245

 cag ggg agc cac tca aaa tgt gag gaa cag gat agg ccc taagtctggg       941
 Gln Gly Ser His Ser Lys Cys Glu Glu Gln Asp Arg Pro 
             250                 255

 ccctttgagt caggaaacca gggccagttc tttttcagga gttaaatgtt tacgcatttc   1001

 caaggttgcg ttttgggagg ggacatgggt tctctccttc ctgctattta ggcattctcc   1061

 aggttcgaga tccacccgtg tgtctggaag ggactgcggg accattcctt ccatcctctt   1121

 tatttcctga ggtccagaga aggaaggaga cttagcagcc acagagcaag accccaatct   1181

 cctgactgca ctggcctgac tgccccctcc caggggatgt taatgaaatg aaggaagtgg   1241

 ggaatgtcac ccgagactgt cacaggcttg ccataccttt ggcctacaca ccgggctcta   1301

 gagccataat ttccaacctg gggagtctcc tgtgcactta aatccgaggt aggctgcagt   1361

 atcggcttga agctctgaca ctgtcagaga aagtggattt attgtgtcat aggagtttct   1421

 gggacccagc tcttcctgag aggggtggga agattgggga tgggatcctc actcagcagt   1481

 ctgggtaggg ccctttgagg cagagggtct tcggccagtg aagagagatt tattctgctc   1541

 agagtgctgg ggtcccatcc tttctccctg gctgccctgt taacagatgg tgctggacct   1601

 tgccccggaa ggggcttgta gcttttttac gtcaacgaaa tgccctcctg tactctgtct   1661

 tcagcagcca actcctggag ctgccaagtg aggggttaaa gaagaggtgg ggaggcagtg   1721

 tggctccctg ggaaaagtct gttgctttgg ttctcagtcc tgggtattct aggagcttgg   1781

 acacgggatt gcgtttcctg tgctaaaatt ctctctcctg gctgggctcc ggtaaactga   1841

 agctgctcga gaaatcacct gggaactctc atagccgttt gtcacccagg gtgtacttgc   1901

 caggacctct ccttgctact cttcccaaag tcgggaggca aagcggctgg gtcaccagag   1961

 cctgaccata ctgacgctcc agggggaaga cgcagaggcc gggaagagac accccctccc   2021

 aaacacataa aacttgcccc ttcctagcct cggctcccct cactggggcc ttgggcagga   2081

 ccgacccgca tccaactagg cctaaggggt aggctctgag cctcttaccc ctaagaggcg   2141

 gagatgcgcc caaggcgggc gcccggcctg ttccccagcc ctgcctggaa gccccgcagc   2201

 cactgcattt tgtttaaaca cagatagcac gggcctttct cttattgcta cagtgttttg   2261

 tacacggtta aaacactagt aaagcttttt cgttattaaa aaaaaaaaaa aa           2313




      <210> 25
      <211> 830
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (136)..(276)

      <400> 25
 tcgcgatcta gaacccccca tactccttac actattcctc atcacccaac taaaaatatt     60

 aaacacaaac taccacctac ctccctcacc aaagcccata aaaataaaaa attataacaa    120

 accctgagaa ccaaa atg aac gaa aat ctg ttc gct tca ttc att gcc ccc     171
                  Met Asn Glu Asn Leu Phe Ala Ser Phe Ile Ala Pro
                    1               5                  10

 aca atc cta ggc cta ccc gcc gca gta ctg atc att cta ttt ccc cct      219
 Thr Ile Leu Gly Leu Pro Ala Ala Val Leu Ile Ile Leu Phe Pro Pro
          15                  20                  25

 cta ttg atc ccc acc tcc aaa tat ctc atc aac aac cga cta atc acc      267
 Leu Leu Ile Pro Thr Ser Lys Tyr Leu Ile Asn Asn Arg Leu Ile Thr
      30                  35                  40

 acc caa caa tgactaa tcaaactaac ctcaaaacaa atgataacca tacacaacac      323
 Thr Gln Gln 
  45

 taaaggacga acctgatctc ttatactagt atccttaatc atttttattg ccacaactaa    383

 cctcctcgga ctcctgcctc actcatttac accaaccacc caactatcta taaacctagc    443

 catggccatc cccttatgag cgggcgcagt gattataggc tttcgctcta agattaaaaa    503

 tgccctagcc cacttcttac cacaaggcac acctacaccc cttatcccca tactagttat    563

 tatcgaaacc atcagcctac tcattcaacc aatagccctg gccgtacgcc taaccgctaa    623

 cattactgca ggccacctac tcatgcacct aattggaagc gccaccctag caatatcaac    683

 cattaacctt ccctctacac ttatcatctt cacaattcta attctactga ctatcctaga    743

 aatcgctgtc gccttaatcc aagcctacgt tttcacactt ctagtaagcc tctacctgca    803

 cgacaacaca taaaaaaaaa aaaaaaa                                        830




      <210> 26
      <211> 1484
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (627)..(1046)

      <400> 26
 aatgcttttt tttttttttt tttctttcca ttttttatta attgaagcac agagaaaaga     60

 ggcaaaatga ttaaagaaat ttatgttttt tagacagggt gttggcttta caccaacgaa    120

 aaagaaaaac agatgaataa gcttttgatc ttcattttct ttctcttatt ctcatggtag    180

 gctgagatgc ttttaaatgt gatgttataa gcctaaggca gcttgacttg cagcaacaag    240

 ttttttaccc tcctcggcaa agcaggtctc cttatcgtca gccttgcagc acttctctac    300

 aaaagctgcg aaatcatcca taacagcttt cagttgctct tttgttgcct tgggcttgtg    360

 tttcacaagc tcaacaagtg cagtttgttt cttgatttgt ctctccttct cagaaagtgt    420

 gcatatatct gcatggaagg tgaatgtttc agcattaaac tctttgggaa cgtatgtttc    480

 atcgacttcc agagctgaaa agcatggtcg cctgttcacc aaggattctg tgcagcattt    540

 ggtgactctg tcacttactg gcgttttctc atgcaacaca cataactggt tcaggaccac    600

 ggatagatag tcttctgcac agggca ttc ttt ttg ctt cag gat gtt tac aac     653
                              Met Pro Cys Ala Glu Asp Tyr Leu Ser
                                1               5

 att tgc tgc cca ctt ttc cta ggt ttc ttg aga cct cta caa aat tgt      701
 Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser
  10                  15                  20                  25

 gag ctt ttt gag cag ctt gga gag tac aaa ttc cag aat gcg cta tta      749
 Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro
                  30                  35                  40

 gtt cgg tta cac caa gaa agt acc cca agt gtc aac tcc aac tct tgt      797
 Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe
              45                  50                  55

 aga ggt ctc aag aaa cct agg aaa agt ggg cag caa atg ttg taa aca      845
 Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu
          60                  65                  70

 tcc tga agc aaa aag aat gcc ctg tgc aga aga cta tct atc cgt ggt      893
 Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys
      75                  80                  85

 cct gaa cca gtt atg tgt gtt gca tga gaa aac gcc agt aag tga cag      941
 His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp
  90                  95                 100                 105

 agt cac caa atg ctg cac aga atc ctt ggt gaa cag gcg acc atg ctt      989
 Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr
                 110                 115                 120

 ttc agc tct gga agt cga tga aac ata cgt tcc caa aga gtt taa tgc     1037
 Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala
             125                 130                 135

 tga aac att caccttc catgcagata tatgcacact ttctgagaag gagagacaaa     1093
 Leu Gly Leu 
         140

 tcaagaaaca aactgcactt gttgagctcg tgaaacacaa gcccaaggca acaaaagagc   1153

 aactgaaagc tgttatggat gatttcgcag cttttgtaga gaagtgctgc aaggctgacg   1213

 ataaggagac ctgctttgcc gaggagggta aaaaacttgt tgctgcaagt caagctgcct   1273

 taggcttata acatcacatt taaaagcatc tcagcctacc atgagaataa gagaaagaaa   1333

 atgaagatca aaagcttatt catctgtttt tctttttcgt tggtgtaaag ccaacaccct   1393

 gtctaaaaaa cataaatttc tttaatcatt ttgcctcttt tctctgtgct tcaattaata   1453

 aaaaatggaa agaatctaaa aaaaaaaaaa a                                  1484




      <210> 27
      <211> 1289
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (204)..(725)

      <400> 27
 taagcttgcg gccgcggcgc ggggctccct tcctcgtgct cggcgttgag ctcctgcagc     60

 cgccgccgct gcagtggtcg tccctgccct ccccggcccc ggggtgcacc ccgcaaggct    120

 cccgctggtg tccctggagc atgggaggct gctgagcgtg agtggcggtg tctggcagga    180

 gctgcgtggc agggagggcg tcc    atg gct gca gcc aac aag ggc aac aag     230
                              Met Ala Ala Ala Asn Lys Gly Asn Lys
                                1               5

 ccc aga gtc cgg agt atc cgc ttt gcg gca ggc cac gat gca gaa gga      278
 Pro Arg Val Arg Ser Ile Arg Phe Ala Ala Gly His Asp Ala Glu Gly
  10                  15                  20                  25

 tcc cac agc cac gtc cac ttt gat gag aag ctg cat gac tcg gtg gtc      326
 Ser His Ser His Val His Phe Asp Glu Lys Leu His Asp Ser Val Val
                  30                  35                  40

 atg gtc acc cag gag agt gac agc agc ttt ctg gtc aag gtt ggc ttc      374
 Met Val Thr Gln Glu Ser Asp Ser Ser Phe Leu Val Lys Val Gly Phe
              45                  50                  55

 ctg aag atc ctg cac agg tat gag att acc ttc act ctg ccc cca gtg      422
 Leu Lys Ile Leu His Arg Tyr Glu Ile Thr Phe Thr Leu Pro Pro Val
          60                  65                  70

 cac agg ctg agc aag gat gtc cgc gag gca cct gtc ccc agc ctg cac      470
 His Arg Leu Ser Lys Asp Val Arg Glu Ala Pro Val Pro Ser Leu His
      75                  80                  85

 ctc aag ctc ctc agc gtg gtg ccc gtc cct gaa ggt tat agt gtc aag      518
 Leu Lys Leu Leu Ser Val Val Pro Val Pro Glu Gly Tyr Ser Val Lys
  90                  95                 100                 105

 tgt gag tac tcg gcg cac aaa gag ggc gtc ctc aaa gag gag ata ctg      566
 Cys Glu Tyr Ser Ala His Lys Glu Gly Val Leu Lys Glu Glu Ile Leu
                 110                 115                 120

 cta gcc tgc gaa ggt ggc act ggc acc tgt gtg cgc gtg acg gtg cag      614
 Leu Ala Cys Glu Gly Gly Thr Gly Thr Cys Val Arg Val Thr Val Gln
             125                 130                 135

 gcc cgc gtc atg gac cgg cac cac ggc acg ccc atg ctg ctg gat ggt      662
 Ala Arg Val Met Asp Arg His His Gly Thr Pro Met Leu Leu Asp Gly
         140                 145                 150

 gtc aag tgt gtg ggc gcc gag ctg gaa tac gac tca gag cac agc gac      710
 Val Lys Cys Val Gly Ala Glu Leu Glu Tyr Asp Ser Glu His Ser Asp
     155                 160                 165

 tgg cac ggc ttt gac tgaggcccga ggccccgcct gccccgggcc cctcagcctt      765
 Trp His Gly Phe Asp 
 170

 aaaccccgcc ttgtcccccc gacatgctgc gtgatggtgt ggcttcctcg cccctctctg    825

 gggtgggtgt gggggtggag tggccttgcc cacgcctctc acctctgcct tcatttgtgc    885

 tgccaccctg cccctccctc gtcctcctct cccacttcct cctctctgtg tgcctcagtc    945

 tcctgccgga agaaatgggt tgagcccgaa aggaggctgt ctgaggaagg gagagggagg   1005

 gcctggggtg ggtcccccac tccccacccc aagccacagg gactcccacc agggtctggg   1065

 agaggacgga gctggctctg tggcgtcgtg gccccattac tgctgccttg cttcagccac   1125

 ctctcctgcc cctccctagt ccccactgct gtccaccatg agtaggaggg aggtgcagtc   1185

 cccagccccc acccctcagg tctgtgttac ttggttttta agcgactggt tgggatagaa   1245

 ccctaaagaa ataaacttcc agtggatacc ggaaaaaaaa aaaa                    1289




      <210> 28
      <211> 2632
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (590)..(1297)

      <400> 28
 cggggcatgc tgcttccctt caccttccac catgattgta agtttcctga ggcctcccca     60

 ggtgtgcttc tgtacagcct gtggaatgtt accaaagacg ttggaagagg tggctatggg    120

 acatcacctg ggagaagtgg aagcaaatgg acactgttca gaagtccata tacagaaaca    180

 tacttggaaa aatatagaaa cctggttttg ctagatggga agcttgaacg tggggccaag    240

 acatcaagag tagagcagca ggacatttca aaagaagatt aatctcaaag attagagatg    300

 gaagaacttg caaagagaaa gtctgtaccg gaagaaatct ggaaatctag aggccagttt    360

 aagaatcagc agctaaacaa ggagaataat ctagggcaag agatagctac ctgcacaaaa    420

 attcctacca gaaaaagaga catagaatct aatgaatttg tgaaaaattt tactgtaaga    480

 tcaatacttg ttgcagaaca gatagatcct atggaagaga attgtcataa atatggtaca    540

 tgttgaaaga tgctcaaaca aaactcagat ttaattatac aaagaaagt    atg atg     595
                                                          Met Met
                                                            1

 gaa aaa aaa aaa cct tgt aaa tat agt gaa tgt ggg aga acc ttc aga      643
 Glu Lys Lys Lys Pro Cys Lys Tyr Ser Glu Cys Gly Arg Thr Phe Arg
           5                  10                  15

 ggc cac atc act ctt gtt cag cat caa ata act cat tgt gga gag aga      691
 Gly His Ile Thr Leu Val Gln His Gln Ile Thr His Cys Gly Glu Arg
      20                  25                  30

 ccc tgt aaa tgt act gag tgt aga aag gga ttt aat cag agt tcc cac      739
 Pro Cys Lys Cys Thr Glu Cys Arg Lys Gly Phe Asn Gln Ser Ser His
  35                  40                  45                  50

 tta aga aat aat cag aga aaa act ctt tca gga gaa aag ccc tac aaa      787
 Leu Arg Asn Asn Gln Arg Lys Thr Leu Ser Gly Glu Lys Pro Tyr Lys
                  55                  60                  65

 tgc agt gag tgt ggg aag gcc ttc agt tat tgc tta gtt ctt aat caa      835
 Cys Ser Glu Cys Gly Lys Ala Phe Ser Tyr Cys Leu Val Leu Asn Gln
              70                  75                  80

 cac cag aga att cac agt gga gag aaa cct tat gag ggt act gaa tgt      883
 His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Gly Thr Glu Cys
          85                  90                  95

 ggc aag aca ttc att cag tcg tac ata cct tac tca gca tca aag aat      931
 Gly Lys Thr Phe Ile Gln Ser Tyr Ile Pro Tyr Ser Ala Ser Lys Asn
     100                 105                 110

 tca cac act ggt gag aag ccc tat aca tgt ctt gaa tgt gga agg ctt      979
 Ser His Thr Gly Glu Lys Pro Tyr Thr Cys Leu Glu Cys Gly Arg Leu
 115                 120                 125                 130

 ttt agt cag aac aca cat ctt act cta cat cag aga atc cat act gga     1027
 Phe Ser Gln Asn Thr His Leu Thr Leu His Gln Arg Ile His Thr Gly
                 135                 140                 145

 gag aaa cct tat gaa tgc aat gaa tgt ggt agg tcc ttt agt cag act     1075
 Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Arg Ser Phe Ser Gln Thr
             150                 155                 160

 gca cat ctt act caa cat caa aga atg tat aca gga gaa aaa ctc tat     1123
 Ala His Leu Thr Gln His Gln Arg Met Tyr Thr Gly Glu Lys Leu Tyr
         165                 170                 175

 gaa tgt aat gaa tgt gag aaa gcc ttc cat gat cac tca gct ctt att     1171
 Glu Cys Asn Glu Cys Glu Lys Ala Phe His Asp His Ser Ala Leu Ile
     180                 185                 190

 caa cat cat att gtc cat act gca gag aaa ccc tat gaa tat cat gac     1219
 Gln His His Ile Val His Thr Ala Glu Lys Pro Tyr Glu Tyr His Asp
 195                 200                 205                 210

 tgg gaa aac ttt cag tta ctg ttc aga cct cat tca aca tca gag aat     1267
 Trp Glu Asn Phe Gln Leu Leu Phe Arg Pro His Ser Thr Ser Glu Asn
                 215                 220                 225

 gca cac tgg aga gaa acc ata caa atg caa t gaatgtggga atgcctttag     1318
 Ala His Trp Arg Glu Thr Ile Gln Met Gln 
             230                 235

 tgattgttca tcccttattc agcatcaaag aactcacacc ggagaagagc cttatgaatg   1378

 taagcaatgt ggaaaagcct ttagcagaag cacatacctt actcaacatc agagaagtca   1438

 cgcaggagag aaacagtata aatgcaatga atgtgagaaa actttcagcc tgagttcatt   1498

 ccttacacag catatgaggg ttcagactgg agaaaaaccc tacaaatata atgaatatgg   1558

 aaaagctttt agtgactgct caggacattt tcagagaact cacactggag agaagccctg   1618

 tgaatgtaat gactgtggga aacctttcag tttctgttca gccctaattc aacataagag   1678

 aattcatacc agaaagaagc cctgactgta ccttcatacc agtaaatgca ctgactgtgg   1738

 aaaagccttc agtgattggt tagcacttgt tcaacatcag ataactcaac actggagaaa   1798

 aaccgtataa atgtactgaa tgtggaaaag ccttcagttg gagtacagac ctcaaaaatc   1858

 accagaaaac tcatactagt gaaaaatcct ataaatgtaa tgaatgtaga aaggccttta   1918

 gttactgctc tggtcttatt caatgtcagg tcattcatac tatagaaaaa ccttatgaat   1978

 acggtaaatg tggcaaagcc tttaggcaga ggacagacct taaaaaacat cagaaaatgc   2038

 ataccgaaga gaaaccctat gaatgtaatg aatgtgggaa agcctttagc cagagcacat   2098

 atcttacaaa acaccaaaaa attcatagtg aagagaaatc aaatatacat actgagtgtg   2158

 gggaaaccat tagacaaaac tcttcttttt tacaacaata aaacctcaca ctggagagat   2218

 tctctgaatg ccttaagaat ttggttaata tggagaccct tcccagggaa acagaaggag   2278

 gatcgtgaaa actgttgact acttagaatg atcacatggt ttagtggaga gagcatgatt   2338

 ctgggtttta aaagtcatgg atctcaatct cagctcctat tactaactag atcttttact   2398

 ttggggtaag tcacttcata tctttaggcc ttaatttcct catctgaaaa actggaaggc   2458

 ctgacttgtt gagctttaag atcctcaatt attatattta ctaggaattc aagtttctat   2518

 agatgtggtt cagaattgtg acttatttat tgtacatcag gtgtgattca caagtgagct   2578

 tgtagtagtt attaaggagt caataaagat atgatataga gcaaaaaaaa aaaa         2632




      <210> 29
      <211> 1108
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(625)

      <400> 29
 tgccgggtga aatcgtagga cagtgaag   atg ctg ctg gaa ttg tcc gag gag      52
                                  Met Leu Leu Glu Leu Ser Glu Glu
                                    1               5

 cat aag gaa cac ctg gcc ttc ctg cct caa gtg gac agc gcg gtg gtc      100
 His Lys Glu His Leu Ala Phe Leu Pro Gln Val Asp Ser Ala Val Val
      10                  15                  20

 gcc gag ttt ggg cgg att gct gtg gaa ttc ctg aga cgc ggc gca aac      148
 Ala Glu Phe Gly Arg Ile Ala Val Glu Phe Leu Arg Arg Gly Ala Asn
  25                  30                  35                  40

 cca aaa atc tac gaa ggc gcc gcc aga aaa ctc aat gtg agt agt gac      196
 Pro Lys Ile Tyr Glu Gly Ala Ala Arg Lys Leu Asn Val Ser Ser Asp
                  45                  50                  55

 act gtc cag cat ggt gtg gaa gga tta acg tat ctc ctc act gag agc      244
 Thr Val Gln His Gly Val Glu Gly Leu Thr Tyr Leu Leu Thr Glu Ser
              60                  65                  70

 tca aag ctc atg att tct gaa ctg gat ttc caa gac tct gtt ttt gtt      292
 Ser Lys Leu Met Ile Ser Glu Leu Asp Phe Gln Asp Ser Val Phe Val
          75                  80                  85

 ctg gga ttc tct gaa gaa tta aac aaa ttg ttg ctt cag ctt tat ctg      340
 Leu Gly Phe Ser Glu Glu Leu Asn Lys Leu Leu Leu Gln Leu Tyr Leu
      90                  95                 100

 gac aac aga aaa gag atc aga acg ctt ctg agt gaa ttg gca cca agc      388
 Asp Asn Arg Lys Glu Ile Arg Thr Leu Leu Ser Glu Leu Ala Pro Ser
 105                 110                 115                 120

 ctt ccc agt tat cat aac ctt gaa tgg cga cta gat gta cag ctt gca      436
 Leu Pro Ser Tyr His Asn Leu Glu Trp Arg Leu Asp Val Gln Leu Ala
                 125                 130                 135

 agt aga agt ctc agg caa cag att aaa cca gca gtg act ata aag cta      484
 Ser Arg Ser Leu Arg Gln Gln Ile Lys Pro Ala Val Thr Ile Lys Leu
             140                 145                 150

 cac ctt aat caa aat gga gat cac aac acc aaa gtt ctg cag aca gac      532
 His Leu Asn Gln Asn Gly Asp His Asn Thr Lys Val Leu Gln Thr Asp
         155                 160                 165

 cca gcc acc ctg ctc cat ttg gtt caa caa ctg gaa caa gca ttg gaa      580
 Pro Ala Thr Leu Leu His Leu Val Gln Gln Leu Glu Gln Ala Leu Glu
     170                 175                 180

 gag atg aag aca aat cac tgt agg aga gtt gtt cgc aac atc aag tag      628
 Glu Met Lys Thr Asn His Cys Arg Arg Val Val Arg Asn Ile Lys 
 185                 190                 195

 taccagtttt aaggttttaa ttcatttgaa tcacttatga attgatgata tacagcaatt    688

 acttttcaaa attaattttt tattaattca tgatgataaa tacatagtat tcctcagtat    748

 ctattccaag atactgaggt cataatcaga agctaagctg ggtgcagtgg ctcatgccag    808

 ttatcccagc actttgggag gccgaggtgg gcaaatcatg aggtcaggag attgagacct    868

 tcctggctaa catggtgaaa ccccatctct actaaaaata taaaaaatta gccaggtgtg    928

 gtggcacgca tctatcagag tcccagctac tcaggaggct gaggcaggag aatcgcttga    988

 acctgggagg tggaggttgc agtgagctga gattgtgcca ctgcactcca gcctgggtga   1048

 cagagtgaga ctccatctca aaaataataa taataataat aaagtaaaaa aaaaaaaaaa   1108




      <210> 30
      <211> 1022
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(864)

      <400> 30
 cgcctccgcc ccatccccag gggccgcctc ccccggggcg gcctccaggc tgccgagacc     60

 tataaaggcg ccaggttttc tcaatgaagc cgggacgcac tccggagcgc actgcgtggt    120

 cgcaccctac ccgggctgcc ttggaagtcg tccccgccgc ccctccgcac cggc  atg     177
                                                              Met
                                                                1

 aag ctc atc gtg ggc atc gga ggc atg acc aac ggc ggc aag acc acg      225
 Lys Leu Ile Val Gly Ile Gly Gly Met Thr Asn Gly Gly Lys Thr Thr
               5                  10                  15

 ctg acc aac agc ctg ctc aga gcc ctg ccc aac tgc tgc gtg atc cat      273
 Leu Thr Asn Ser Leu Leu Arg Ala Leu Pro Asn Cys Cys Val Ile His
          20                  25                  30

 cag gat gac ttc ttc aag ccc caa gac caa ata gca gtt ggg gaa gac      321
 Gln Asp Asp Phe Phe Lys Pro Gln Asp Gln Ile Ala Val Gly Glu Asp
      35                  40                  45

 ggc ttc aaa cag tgg gac gtg ctg gag tct ctg gac atg gag gcc atg      369
 Gly Phe Lys Gln Trp Asp Val Leu Glu Ser Leu Asp Met Glu Ala Met
  50                  55                  60                  65

 ctg gac acc gtg cag gcc tgg ctg agc agc ccg cag aag ttt gcc cgt      417
 Leu Asp Thr Val Gln Ala Trp Leu Ser Ser Pro Gln Lys Phe Ala Arg
                  70                  75                  80

 gcc cac ggg gtc agc gtc cag cca gag gcc tcg gac acc cac atc ctc      465
 Ala His Gly Val Ser Val Gln Pro Glu Ala Ser Asp Thr His Ile Leu
              85                  90                  95

 ctt ctg gaa ggc ttc ctg ctc tac agc tac aag ccc ctg gtg gac ttg      513
 Leu Leu Glu Gly Phe Leu Leu Tyr Ser Tyr Lys Pro Leu Val Asp Leu
         100                 105                 110

 tac agc cgc cgg tac ttc ctg acc gtc ccg tat gaa gag tgc aag tgg      561
 Tyr Ser Arg Arg Tyr Phe Leu Thr Val Pro Tyr Glu Glu Cys Lys Trp
     115                 120                 125

 agg aga agt acc cgc aac tac aca gtc cct gat ccc ccc ggc ctc ttc      609
 Arg Arg Ser Thr Arg Asn Tyr Thr Val Pro Asp Pro Pro Gly Leu Phe
 130                 135                 140                 145

 gat ggc cac gtg tgg ccc atg tac cag aag tat agg cag gag atg gag      657
 Asp Gly His Val Trp Pro Met Tyr Gln Lys Tyr Arg Gln Glu Met Glu
                 150                 155                 160

 gcc aac ggt gtg gaa gtg gtc tac ctg gac ggc atg aag tcc cga gag      705
 Ala Asn Gly Val Glu Val Val Tyr Leu Asp Gly Met Lys Ser Arg Glu
             165                 170                 175

 gag ctc ttc cgt gaa gtc ctg gaa gac att cag aac tcg ctg ctg aac      753
 Glu Leu Phe Arg Glu Val Leu Glu Asp Ile Gln Asn Ser Leu Leu Asn
         180                 185                 190

 cgc tcc cag gaa tca gcc ccc tcc ccg gct cgc cca gcc agg aca cag      801
 Arg Ser Gln Glu Ser Ala Pro Ser Pro Ala Arg Pro Ala Arg Thr Gln
     195                 200                 205

 gga ccc gga cgc gga tgc ggc cac aga acg gcc agg cct gca gcg tcc      849
 Gly Pro Gly Arg Gly Cys Gly His Arg Thr Ala Arg Pro Ala Ala Ser
 210                 215                 220                 225

 cag cag gac agc atg tgagcgtttc cctatggggg tgtctgtacg taggagagtg      904
 Gln Gln Asp Ser Met 
                 230

 gaggccccac tcccagttgg gcgtcccgga gctcagggac tgagccccaa gacgcctctg    964

 taacctcgct gcagcttcag tagtaaactg ggtcctgttt ttttaaaaaa aaaaaaaa     1022




      <210> 31
      <211> 1528
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (281)..(1525)

      <400> 31
 ggaagaattg aaaagtgact acaattaaag accttagtat gatttaggga aaaaaggctg     60

 gggtcagtta cctttctctc ttaaggagat tccttgatga tatggttctt cctctccagc    120

 tgtgatccca cttacagatt cagagtataa gctgctgccc ttgcactttg ctgtggaccc    180

 tggaaagggc tgggagtggg gcaaagatga tagtgacaat gtccgattgg ccagtgtaat    240

 tctgtcccta gaggtcaaat tgcatctgct gcatagctac  atg aat gtg aag tgg     295
                                              Met Asn Val Lys Trp
                                                1               5

 atc cca ctg tcc tct gat gca cag gct cct ctg gcc cag cct gag tcc      343
 Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln Pro Glu Ser
                  10                  15                  20

 ccc acc gcc tca gct gga gat gag ccc cgg tcc act cct gag tct gga      391
 Pro Thr Ala Ser Ala Gly Asp Glu Pro Arg Ser Thr Pro Glu Ser Gly
              25                  30                  35

 gac tca gac aag gag tca gtt ggc agc agt tcc acc agc aac gag ggc      439
 Asp Ser Asp Lys Glu Ser Val Gly Ser Ser Ser Thr Ser Asn Glu Gly
          40                  45                  50

 ggc cgg cgg aag gag aag tca aag cga gat cgg gag aag gac aag aag      487
 Gly Arg Arg Lys Glu Lys Ser Lys Arg Asp Arg Glu Lys Asp Lys Lys
      55                  60                  65

 aga gca gat tct gtg gct aac aaa ctg ggc agc ttt ggc aaa acc ttg      535
 Arg Ala Asp Ser Val Ala Asn Lys Leu Gly Ser Phe Gly Lys Thr Leu
  70                  75                  80                  85

 ggc agc aag ctc aag aag aac atg ggg ggc ctg atg cac agc aag ggt      583
 Gly Ser Lys Leu Lys Lys Asn Met Gly Gly Leu Met His Ser Lys Gly
                  90                  95                 100

 tca aag cct gga ggg gtg ggg aca ggg ttg gga gga agc agc ggc act      631
 Ser Lys Pro Gly Gly Val Gly Thr Gly Leu Gly Gly Ser Ser Gly Thr
             105                 110                 115

 gag aca ctg gaa aaa aaa aaa aaa aac tca ctg aag agc tgg aag ggt      679
 Glu Thr Leu Glu Lys Lys Lys Lys Asn Ser Leu Lys Ser Trp Lys Gly
         120                 125                 130

 ggc aag gag gag gca gct ggg gat ggg cct gtg tct gag aag ccc cca      727
 Gly Lys Glu Glu Ala Ala Gly Asp Gly Pro Val Ser Glu Lys Pro Pro
     135                 140                 145

 gct gag tct gtt ggt aac gga ggg agc aag tat agc cag gag gtg atg      775
 Ala Glu Ser Val Gly Asn Gly Gly Ser Lys Tyr Ser Gln Glu Val Met
 150                 155                 160                 165

 cag agc ctg agc att ctg agg act gcc atg caa ggg gag ggg aag ttt      823
 Gln Ser Leu Ser Ile Leu Arg Thr Ala Met Gln Gly Glu Gly Lys Phe
                 170                 175                 180

 att ttt gtt gga acc ctg aag atg ggt cac cgt cac cag tat cag gag      871
 Ile Phe Val Gly Thr Leu Lys Met Gly His Arg His Gln Tyr Gln Glu
             185                 190                 195

 gaa atg atc cag cgc tac ctt tct gat gct gag gag aga ttc ctg gca      919
 Glu Met Ile Gln Arg Tyr Leu Ser Asp Ala Glu Glu Arg Phe Leu Ala
         200                 205                 210

 gaa cag aag cag aag gag gca gag agg aag atc atg aat gga gga ata      967
 Glu Gln Lys Gln Lys Glu Ala Glu Arg Lys Ile Met Asn Gly Gly Ile
     215                 220                 225

 ggg ggt ggc cct cct cca gcc aaa aag cca gag cca gat gct agg gaa     1015
 Gly Gly Gly Pro Pro Pro Ala Lys Lys Pro Glu Pro Asp Ala Arg Glu
 230                 235                 240                 245

 gag cag ccg acc ggt ccc cca gca gag tcc agg gca atg gca ttt tcc     1063
 Glu Gln Pro Thr Gly Pro Pro Ala Glu Ser Arg Ala Met Ala Phe Ser
                 250                 255                 260

 act ggc tac cct ggg gac ttt act atc cct cgg ccg tct ggg ggc gga     1111
 Thr Gly Tyr Pro Gly Asp Phe Thr Ile Pro Arg Pro Ser Gly Gly Gly
             265                 270                 275

 gtc cac tgc cag gaa ccc cgg agg cag ttg gca ggg ggt cca tgt gtc     1159
 Val His Cys Gln Glu Pro Arg Arg Gln Leu Ala Gly Gly Pro Cys Val
         280                 285                 290

 ggg ggc cta cca cca tat gcc acc ttc ccc aga cag tgc cct cct ggg     1207
 Gly Gly Leu Pro Pro Tyr Ala Thr Phe Pro Arg Gln Cys Pro Pro Gly
     295                 300                 305

 cga ccc tac ccc cac cag gac agc atc cct tct ctg gag cca ggc agc     1255
 Arg Pro Tyr Pro His Gln Asp Ser Ile Pro Ser Leu Glu Pro Gly Ser
 310                 315                 320                 325

 cac tct aag gat gga ctt cac agg ggt gcc ttg tta cca ccc ccc tac     1303
 His Ser Lys Asp Gly Leu His Arg Gly Ala Leu Leu Pro Pro Pro Tyr
                 330                 335                 340

 cga gtg gct gat tcc tat agc aat ggc tac aga gag ccc cct gag cca     1351
 Arg Val Ala Asp Ser Tyr Ser Asn Gly Tyr Arg Glu Pro Pro Glu Pro
             345                 350                 355

 gat gga tgg gct gga ggt ctc cgg ggc ctt ccc cca act cag acc aaa     1399
 Asp Gly Trp Ala Gly Gly Leu Arg Gly Leu Pro Pro Thr Gln Thr Lys
         360                 365                 370

 tgc aaa caa ccg aac tgc agc ttc tat gga cac cct gag aca aac aac     1447
 Cys Lys Gln Pro Asn Cys Ser Phe Tyr Gly His Pro Glu Thr Asn Asn
     375                 380                 385

 ttc tgt tcc tgt tgt tac agg gaa gaa ctg agg agg agg gag cgg gaa     1495
 Phe Cys Ser Cys Cys Tyr Arg Glu Glu Leu Arg Arg Arg Glu Arg Glu
 390                 395                 400                 405

 ccg gat ggg gag ctc ctg gtg cac agg ttc tga                         1528
 Pro Asp Gly Glu Leu Leu Val His Arg Phe 
                 410                 415





      <210> 32
      <211> 2537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(1890)

      <400> 32
 aaggatcctt aattaaatta atctcccccc cccccccccg ccccactctg gactcccgcg     60

 ctgggcgcgc tgaggcggcc cccgagcgag cgcgcgtgca gccgccgccg ccccgagcac    120

 ccgcagctcc ggcgccgcgg cgagacggag acggaccgag ccacgggccc ccgcggccgc    180

 agcatctcgg aggagaac  atg ctt gcc aac tca gcc agc gtg agg atc ctc     231
                      Met Leu Ala Asn Ser Ala Ser Val Arg Ile Leu
                        1               5                  10

 atc aag gga ggc aag gtg gtg aac gat gac tgc acc cac gag gct gac      279
 Ile Lys Gly Gly Lys Val Val Asn Asp Asp Cys Thr His Glu Ala Asp
              15                  20                  25

 gtc tac atc gag aat ggc atc atc cag cag gtg ggc cgc gag ctc atg      327
 Val Tyr Ile Glu Asn Gly Ile Ile Gln Gln Val Gly Arg Glu Leu Met
          30                  35                  40

 atc cct ggc ggg gcc aag gtg att gat gcc aca gga aaa ctg gtg atc      375
 Ile Pro Gly Gly Ala Lys Val Ile Asp Ala Thr Gly Lys Leu Val Ile
      45                  50                  55

 cct ggt ggc atc gac acc agc acc cac ttc cac cag acc ttc atg aat      423
 Pro Gly Gly Ile Asp Thr Ser Thr His Phe His Gln Thr Phe Met Asn
  60                  65                  70                  75

 gcc acg tgc gtg gac gac ttc tac cat ggg acc aag gca gca ctc gtc      471
 Ala Thr Cys Val Asp Asp Phe Tyr His Gly Thr Lys Ala Ala Leu Val
                  80                  85                  90

 gga ggc acc acc atg atc atc ggc cac gtc ctg ccc gac aag gag acc      519
 Gly Gly Thr Thr Met Ile Ile Gly His Val Leu Pro Asp Lys Glu Thr
              95                 100                 105

 tcc ctt gtg gac gct tat gag aag tgc cga ggt ctg gcc gac ccc aag      567
 Ser Leu Val Asp Ala Tyr Glu Lys Cys Arg Gly Leu Ala Asp Pro Lys
         110                 115                 120

 gtc tgc tgt gat tac gcc ctc cac gtg ggg atc acc tgg tgg gca ccc      615
 Val Cys Cys Asp Tyr Ala Leu His Val Gly Ile Thr Trp Trp Ala Pro
     125                 130                 135

 aag gtg aaa gca gaa atg gag aca ctg gtg agg gag aag ggt gtc aac      663
 Lys Val Lys Ala Glu Met Glu Thr Leu Val Arg Glu Lys Gly Val Asn
 140                 145                 150                 155

 tcg ttc cag atg ttc atg acc tac aag gac ctg tac atg ctt cga gac      711
 Ser Phe Gln Met Phe Met Thr Tyr Lys Asp Leu Tyr Met Leu Arg Asp
                 160                 165                 170

 agt gag ctg tac caa gtg ttg cac gct tgc aag gac att ggg gca atc      759
 Ser Glu Leu Tyr Gln Val Leu His Ala Cys Lys Asp Ile Gly Ala Ile
             175                 180                 185

 gcc cgc gtc cat gct gaa aat ggg gag ctt gtg gcc gag ggt gct aag      807
 Ala Arg Val His Ala Glu Asn Gly Glu Leu Val Ala Glu Gly Ala Lys
         190                 195                 200

 gag gca ctg gat ttg ggg atc aca ggc cca gaa gga atc gag atc agc      855
 Glu Ala Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly Ile Glu Ile Ser
     205                 210                 215

 cgt cca gag gag ctg gaa gct gaa gcc act cat cgt gtt atc acc att      903
 Arg Pro Glu Glu Leu Glu Ala Glu Ala Thr His Arg Val Ile Thr Ile
 220                 225                 230                 235

 gca aac agg act cac tgt cca atc tac ctg gtc aac gtg tcc agt atc      951
 Ala Asn Arg Thr His Cys Pro Ile Tyr Leu Val Asn Val Ser Ser Ile
                 240                 245                 250

 tcg gct ggt gac gtt atc gca gct gct aag atg caa ggg aag gtt gtg      999
 Ser Ala Gly Asp Val Ile Ala Ala Ala Lys Met Gln Gly Lys Val Val
             255                 260                 265

 ctg gcg gag acc acc act gca cat gcc acg ctg aca ggc tta cac tac     1047
 Leu Ala Glu Thr Thr Thr Ala His Ala Thr Leu Thr Gly Leu His Tyr
         270                 275                 280

 tac cac cag gac tgg tcc cac gcg gct gcc tat gtc acg gtg cct ccc     1095
 Tyr His Gln Asp Trp Ser His Ala Ala Ala Tyr Val Thr Val Pro Pro
     285                 290                 295

 ctg aga ctg gac acc aac acc tca acc tac ctc atg agc ctg ctg gcc     1143
 Leu Arg Leu Asp Thr Asn Thr Ser Thr Tyr Leu Met Ser Leu Leu Ala
 300                 305                 310                 315

 aat gac act ctg aac atc gtg gca tca gat cac cgg cct ttc acc aca     1191
 Asn Asp Thr Leu Asn Ile Val Ala Ser Asp His Arg Pro Phe Thr Thr
                 320                 325                 330

 aag cag aaa gct atg ggc aag gaa gac ttc acc aag atc cca cat gga     1239
 Lys Gln Lys Ala Met Gly Lys Glu Asp Phe Thr Lys Ile Pro His Gly
             335                 340                 345

 gtg agt ggc gtg cag gac cgc atg agc gtc atc tgg gag aga gga gtg     1287
 Val Ser Gly Val Gln Asp Arg Met Ser Val Ile Trp Glu Arg Gly Val
         350                 355                 360

 gtt gga gga aag atg gat gag aac cgt ttt gtg gcc gtt acc agt tcc     1335
 Val Gly Gly Lys Met Asp Glu Asn Arg Phe Val Ala Val Thr Ser Ser
     365                 370                 375

 aac gca gct aag ctt ctg aac ctg tat ccc cgc aag ggc cgc att att     1383
 Asn Ala Ala Lys Leu Leu Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ile
 380                 385                 390                 395

 ccc gga gcc gat gct gat gtg gtg gtg tgg gac cca gaa gcc aca aag     1431
 Pro Gly Ala Asp Ala Asp Val Val Val Trp Asp Pro Glu Ala Thr Lys
                 400                 405                 410

 acc atc tca gcc agc acg cag gtc cag gga gga gac ttc aac ctg tat     1479
 Thr Ile Ser Ala Ser Thr Gln Val Gln Gly Gly Asp Phe Asn Leu Tyr
             415                 420                 425

 gag aac atg cgc tgc cac ggc gtg cca ctg gtc acc atc agc cgg ggg     1527
 Glu Asn Met Arg Cys His Gly Val Pro Leu Val Thr Ile Ser Arg Gly
         430                 435                 440

 cgc gtc gtg tat gag aac ggc gtc ttc atg tgc gcc gag ggc acc ggc     1575
 Arg Val Val Tyr Glu Asn Gly Val Phe Met Cys Ala Glu Gly Thr Gly
     445                 450                 455

 aag ttc tgt ccc ctg agg tcc ttc cca gac act gtc tac aag aag ctg     1623
 Lys Phe Cys Pro Leu Arg Ser Phe Pro Asp Thr Val Tyr Lys Lys Leu
 460                 465                 470                 475

 gtc cag aga gag aag act tta aag gtt aga gga gtg gac cgc act ccc     1671
 Val Gln Arg Glu Lys Thr Leu Lys Val Arg Gly Val Asp Arg Thr Pro
                 480                 485                 490

 tac ctg ggg gat gtc gct gtt gtc gtg cac cct ggg aaa aaa gag atg     1719
 Tyr Leu Gly Asp Val Ala Val Val Val His Pro Gly Lys Lys Glu Met
             495                 500                 505

 gga acc cca ctc gca gac act cct acc cgg ccc gtc acc cgg cat ggg     1767
 Gly Thr Pro Leu Ala Asp Thr Pro Thr Arg Pro Val Thr Arg His Gly
         510                 515                 520

 ggc atg agg gac ctt cac gaa tcc agc ttc agc ctc tct ggc tct cag     1815
 Gly Met Arg Asp Leu His Glu Ser Ser Phe Ser Leu Ser Gly Ser Gln
     525                 530                 535

 atc gat gac cat gtt cca aag cga gct tca gct cgg atc ctc gct cct     1863
 Ile Asp Asp His Val Pro Lys Arg Ala Ser Ala Arg Ile Leu Ala Pro
 540                 545                 550                 555

 ccc gga ggc agg tcg agt ggc att tgg taaag gcattgccaa gccccccgag     1915
 Pro Gly Gly Arg Ser Ser Gly Ile Trp 
                 560

 tgaggacgca ccgccgccac cagcccgcaa ctctccagcc gaagctgcag gggcaggaga   1975

 ggctgggctg ggtggcacac cacccgaggg gggccccggg acccacggag ccctccctat   2035

 gtctgcaaag tgattcactg tgcttcgagc caactctaac aggcactttg agatgtgttc   2095

 ctcctgctgt agtcctttct gccttggcct cggcgggctt ttctggggcc caggaagccc   2155

 acactatgca cagagcccaa tgcatagagc cctggccagc ccttcctctc actcctgcct   2215

 ccgctggctt tgggaaagcc cagactttag tgccctgccc cctggctgac tggccagttg   2275

 cccagagcac tttagcagat gtggtttcaa agtaaaggcc tcctccccca ccccttaggc   2335

 cccgtggtga catttcccaa gtcagacaga tgtcagcttc ccagccatgc ccaggacgtc   2395

 ctatctcccc caacccacct ctggccctgt gtaggggcag ggatgggggt ggctgggact   2455

 cctggtgccc ctcgccagct tctcctgcgc cccgcccaca ccctcggggg ggtcacaggc   2515

 ccagaagggt agctgggcgg gg                                            2537




      <210> 33
      <211> 1409
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(1219)

      <400> 33
 tctgcacctt cctcccgtct tgccttctcc ctcgagttgg gacccgggaa gaacc atg      58
                                                              Met
                                                                1

 aag tgg ctg ctg ctg ctg ggt ctg gtg gcg ctc tct gag tgc atc atg      106
 Lys Trp Leu Leu Leu Leu Gly Leu Val Ala Leu Ser Glu Cys Ile Met
               5                  10                  15

 tac aag gtc ccc ctc atc aga aag aag tcc ttg agg cgc acc ctg tcc      154
 Tyr Lys Val Pro Leu Ile Arg Lys Lys Ser Leu Arg Arg Thr Leu Ser
          20                  25                  30

 gag cgt ggc ctg ctg aag gac ttc ctg aag aag cac aac ctc aac cca      202
 Glu Arg Gly Leu Leu Lys Asp Phe Leu Lys Lys His Asn Leu Asn Pro
      35                  40                  45

 gcc aga aag tac ttc ccc cag tgg gag gct ccc acc ctg gta gat gaa      250
 Ala Arg Lys Tyr Phe Pro Gln Trp Glu Ala Pro Thr Leu Val Asp Glu
  50                  55                  60                  65

 cag ccc ctg gag aac tac ctg gat atg gag tac ttc ggc act atc ggc      298
 Gln Pro Leu Glu Asn Tyr Leu Asp Met Glu Tyr Phe Gly Thr Ile Gly
                  70                  75                  80

 atc gga act cct gcc cag gat ttc acc gtc gtc ttt gac acc ggc tcc      346
 Ile Gly Thr Pro Ala Gln Asp Phe Thr Val Val Phe Asp Thr Gly Ser
              85                  90                  95

 tcc aac ctg tgg gtg ccc tca gtc tac tgc tcc agt ctt gcc tgc acc      394
 Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Ser Ser Leu Ala Cys Thr
         100                 105                 110

 aac cac aac cgc ttc aac cct gag gat tct tcc acc tac cag tcc acc      442
 Asn His Asn Arg Phe Asn Pro Glu Asp Ser Ser Thr Tyr Gln Ser Thr
     115                 120                 125

 agc gag aca gtc tcc atc acc tac ggc acc ggc agc atg aca ggc atc      490
 Ser Glu Thr Val Ser Ile Thr Tyr Gly Thr Gly Ser Met Thr Gly Ile
 130                 135                 140                 145

 ctc gga tac gac act gtc cag gtt gga ggc atc tct gac acc aat cag      538
 Leu Gly Tyr Asp Thr Val Gln Val Gly Gly Ile Ser Asp Thr Asn Gln
                 150                 155                 160

 atc ttc ggc ctg agc gag acg gaa cct ggc tcc ttc ctg tat tat gct      586
 Ile Phe Gly Leu Ser Glu Thr Glu Pro Gly Ser Phe Leu Tyr Tyr Ala
             165                 170                 175

 ccc ttc gat ggc atc ctg ggg ctg gcc tac ccc agc att tcc tcc tcc      634
 Pro Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro Ser Ile Ser Ser Ser
         180                 185                 190

 ggg gcc aca ccc gtc ttt gac aac atc tgg aac cag ggc ctg gtt tct      682
 Gly Ala Thr Pro Val Phe Asp Asn Ile Trp Asn Gln Gly Leu Val Ser
     195                 200                 205

 cag gac ctc ttc tct gtc tac ctc agc gcc gat gac cag agt ggc agc      730
 Gln Asp Leu Phe Ser Val Tyr Leu Ser Ala Asp Asp Gln Ser Gly Ser
 210                 215                 220                 225

 gtg gtg atc ttt ggt ggc att gac tct tct tac tac act gga agt ctg      778
 Val Val Ile Phe Gly Gly Ile Asp Ser Ser Tyr Tyr Thr Gly Ser Leu
                 230                 235                 240

 aac tgg gtg cct gtt acc gtc gag ggt tac tgg cag atc acc gtg gac      826
 Asn Trp Val Pro Val Thr Val Glu Gly Tyr Trp Gln Ile Thr Val Asp
             245                 250                 255

 agc atc acc atg aac gga gag gcc atc gcc tgc gct gag ggc tgc cag      874
 Ser Ile Thr Met Asn Gly Glu Ala Ile Ala Cys Ala Glu Gly Cys Gln
         260                 265                 270

 gcc att gtt gac acc ggc acc tct ctc ctg acc ggc cca acc agc ccc      922
 Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser Pro
     275                 280                 285

 att gcc aac atc cag agc gac atc gga gcc agc gag aac tca gat ggc      970
 Ile Ala Asn Ile Gln Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp Gly
 290                 295                 300                 305

 gac atg gtg gtc agc tgc tca gcc atc agc agc ctg ccc gac atc gtc     1018
 Asp Met Val Val Ser Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile Val
                 310                 315                 320

 ttc acc atc aat gga gtc cag tac ccc gtg cca ccc agt gcc tac atc     1066
 Phe Thr Ile Asn Gly Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr Ile
             325                 330                 335

 ctg cag agc gag ggg agc tgc atc agt ggc ttc cag ggc atg aac ctc     1114
 Leu Gln Ser Glu Gly Ser Cys Ile Ser Gly Phe Gln Gly Met Asn Leu
         340                 345                 350

 ccc acc gaa tct gga gag ctt tgg atc ctg ggt gat gtc ttc atc cgc     1162
 Pro Thr Glu Ser Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile Arg
     355                 360                 365

 cag tac ttt acc gtc ttc gac agg gca aac aac cag gtc ggc ctg gcc     1210
 Gln Tyr Phe Thr Val Phe Asp Arg Ala Asn Asn Gln Val Gly Leu Ala
 370                 375                 380                 385

 ccc gtg gct taagcct aagtctcttc agccacctcc caggaagatc tggcctctgt     1266
 Pro Val Ala 


 cctgtgccca ctttagatgt atctaattct cctgactgtt cttcccaggg gagtgtggag   1326

 gtcttggccc tgttccctgt cctaccaata acgtagaata aaaacataac ccactgaaac   1386

 aggttttgtg gaaaaaaaaa aaa                                           1409




      <210> 34
      <211> 2800
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (130)..(2592)

      <400> 34
 ggtcgctagg acttccgtcg catttcgtga ctttcaggac ggtggggcac agcgtgtgat     60

 gacggctgga acagtaaagc tgcagctgtg gtgtgtagcc agctggactg cccatcttct    120

 atcattggc    atg ggt ctg gga aac gct tct aca gga tat gga aaa att     168
              Met Gly Leu Gly Asn Ala Ser Thr Gly Tyr Gly Lys Ile
                1               5                  10

 tgg ctc gat gat gtt tcc tgt gat gga gat gag tca gat ctc tgg tca      216
 Trp Leu Asp Asp Val Ser Cys Asp Gly Asp Glu Ser Asp Leu Trp Ser
      15                  20                  25

 tgc agg aac agt ggg tgg gga aat aat gac tgc agt cac agt gaa gat      264
 Cys Arg Asn Ser Gly Trp Gly Asn Asn Asp Cys Ser His Ser Glu Asp
  30                  35                  40                  45

 gtt gga gtg atc tgt tct gat gca tcg gat atg gag ctg agg ctt gtg      312
 Val Gly Val Ile Cys Ser Asp Ala Ser Asp Met Glu Leu Arg Leu Val
                  50                  55                  60

 ggt gga agc agc agg tgt gct gga aaa gtt gag gtg aat gtc cag ggt      360
 Gly Gly Ser Ser Arg Cys Ala Gly Lys Val Glu Val Asn Val Gln Gly
              65                  70                  75

 gcc gtg gga att ctg tgt gct aat ggc tgg gga atg aac att gct gaa      408
 Ala Val Gly Ile Leu Cys Ala Asn Gly Trp Gly Met Asn Ile Ala Glu
          80                  85                  90

 gtt gtt tgc agg caa ctt gaa tgt ggg tct gca atc agg gtc tcc aga      456
 Val Val Cys Arg Gln Leu Glu Cys Gly Ser Ala Ile Arg Val Ser Arg
      95                 100                 105

 gag cct cat ttc aca gaa aga aca tta cac atc tta atg tcg aat tct      504
 Glu Pro His Phe Thr Glu Arg Thr Leu His Ile Leu Met Ser Asn Ser
 110                 115                 120                 125

 ggc tgc act gga ggg gaa gcc tct ctc tgg gat tgt ata cga tgg gag      552
 Gly Cys Thr Gly Gly Glu Ala Ser Leu Trp Asp Cys Ile Arg Trp Glu
                 130                 135                 140

 tgg aaa cag act gcg tgt cat tta aat atg gaa gca agt ttg atc tgc      600
 Trp Lys Gln Thr Ala Cys His Leu Asn Met Glu Ala Ser Leu Ile Cys
             145                 150                 155

 tca gcc cac agg cag ccc agg ctg gtt gga gct gat atg ccc tgc tct      648
 Ser Ala His Arg Gln Pro Arg Leu Val Gly Ala Asp Met Pro Cys Ser
         160                 165                 170

 gga cgt gtt gaa gtg aaa cat gca gac aca tgg cgc tct gtc tgt gat      696
 Gly Arg Val Glu Val Lys His Ala Asp Thr Trp Arg Ser Val Cys Asp
     175                 180                 185

 tct gat ttc tct ctt cat gct gcc aat gtg ctg tgc aga gaa tta aac      744
 Ser Asp Phe Ser Leu His Ala Ala Asn Val Leu Cys Arg Glu Leu Asn
 190                 195                 200                 205

 tgt gga gat gcc ata tct ctt tct gtg gga gat cac ttt gga aaa ggg      792
 Cys Gly Asp Ala Ile Ser Leu Ser Val Gly Asp His Phe Gly Lys Gly
                 210                 215                 220

 aat ggt cta act tgg gcc gaa aag ttc cag tgt gaa ggg agt gaa act      840
 Asn Gly Leu Thr Trp Ala Glu Lys Phe Gln Cys Glu Gly Ser Glu Thr
             225                 230                 235

 cac ctt gca tta tgc ccc att gtt caa cat ccg gaa gac act tgt atc      888
 His Leu Ala Leu Cys Pro Ile Val Gln His Pro Glu Asp Thr Cys Ile
         240                 245                 250

 cac agc aga gaa gtt gga gtt gtc tgt tcc cga tat aca gat gtc cga      936
 His Ser Arg Glu Val Gly Val Val Cys Ser Arg Tyr Thr Asp Val Arg
     255                 260                 265

 ctt gtg aat ggc aaa tcc cag tgt gac ggg caa gtg gag atc aac gtg      984
 Leu Val Asn Gly Lys Ser Gln Cys Asp Gly Gln Val Glu Ile Asn Val
 270                 275                 280                 285

 ctt gga cac tgg ggc tca ctg tgt gac acc cac tgg gac cca gaa gat     1032
 Leu Gly His Trp Gly Ser Leu Cys Asp Thr His Trp Asp Pro Glu Asp
                 290                 295                 300

 gcc cgt gtt cta tgc aga cag ctc agc tgt ggg act gct ctc tca acc     1080
 Ala Arg Val Leu Cys Arg Gln Leu Ser Cys Gly Thr Ala Leu Ser Thr
             305                 310                 315

 aca gga gga aaa tat att gga gaa aga agt gtt cgt gtg tgg gga cac     1128
 Thr Gly Gly Lys Tyr Ile Gly Glu Arg Ser Val Arg Val Trp Gly His
         320                 325                 330

 agg ttt cat tgc tta ggg aat gag tca ctt ctg gat aac tgt caa atg     1176
 Arg Phe His Cys Leu Gly Asn Glu Ser Leu Leu Asp Asn Cys Gln Met
     335                 340                 345

 aca gtt ctt gga gca cct ccc tgt atc cat gga aat act gtc tct gtg     1224
 Thr Val Leu Gly Ala Pro Pro Cys Ile His Gly Asn Thr Val Ser Val
 350                 355                 360                 365

 atc tgc aca gga agc ctg acc cag cca ctg ttt cca tgc ctc gca aat     1272
 Ile Cys Thr Gly Ser Leu Thr Gln Pro Leu Phe Pro Cys Leu Ala Asn
                 370                 375                 380

 gta tct gac cca tat ttg tct gca gtt cca gag ggc agt gct ttg atc     1320
 Val Ser Asp Pro Tyr Leu Ser Ala Val Pro Glu Gly Ser Ala Leu Ile
             385                 390                 395

 tgc tta gag gac aaa cgg ctc cgc cta gtg gat ggg gac agc cgc tgt     1368
 Cys Leu Glu Asp Lys Arg Leu Arg Leu Val Asp Gly Asp Ser Arg Cys
         400                 405                 410

 gcc ggg aga gta gag atc tat cac gac ggc ttc tgg ggc acc atc tgt     1416
 Ala Gly Arg Val Glu Ile Tyr His Asp Gly Phe Trp Gly Thr Ile Cys
     415                 420                 425

 gat gac ggc tgg gac ctg agc gat gcc cac gtg gtg tgt caa aag ctg     1464
 Asp Asp Gly Trp Asp Leu Ser Asp Ala His Val Val Cys Gln Lys Leu
 430                 435                 440                 445

 ggc tgt gga gtg gcc ttc aat gcc acg gtc tct gct cac ttt ggg gag     1512
 Gly Cys Gly Val Ala Phe Asn Ala Thr Val Ser Ala His Phe Gly Glu
                 450                 455                 460

 ggg tca ggg ccc atc tgg ctg gat gac ctg aac tgc aca gga atg gag     1560
 Gly Ser Gly Pro Ile Trp Leu Asp Asp Leu Asn Cys Thr Gly Met Glu
             465                 470                 475

 tcc cac ttg tgg cag tgc cct tcc cgc ggc tgg ggg cag cac gac tgc     1608
 Ser His Leu Trp Gln Cys Pro Ser Arg Gly Trp Gly Gln His Asp Cys
         480                 485                 490

 agg cac aag gag gac gca ggg gtc atc tgc tca gaa ttc aca gcc ttg     1656
 Arg His Lys Glu Asp Ala Gly Val Ile Cys Ser Glu Phe Thr Ala Leu
     495                 500                 505

 agg ctc tac agt gaa act gaa aca gag agc tgt gct ggg aga ttg gaa     1704
 Arg Leu Tyr Ser Glu Thr Glu Thr Glu Ser Cys Ala Gly Arg Leu Glu
 510                 515                 520                 525

 gtc ttc tat aac ggg acc tgg ggc agc gtc ggc agg agg aac atc acc     1752
 Val Phe Tyr Asn Gly Thr Trp Gly Ser Val Gly Arg Arg Asn Ile Thr
                 530                 535                 540

 aca gcc ata gca ggc att gtg tgc agg cag ctg ggc tgt ggg gag aat     1800
 Thr Ala Ile Ala Gly Ile Val Cys Arg Gln Leu Gly Cys Gly Glu Asn
             545                 550                 555

 gga gtt gtc agc ctc gcc cct tta tct aag aca ggc tct ggt ttc atg     1848
 Gly Val Val Ser Leu Ala Pro Leu Ser Lys Thr Gly Ser Gly Phe Met
         560                 565                 570

 tgg gtg gat gac att cag tgt cct aaa acg cat atc tcc ata tgg cag     1896
 Trp Val Asp Asp Ile Gln Cys Pro Lys Thr His Ile Ser Ile Trp Gln
     575                 580                 585

 tgc ctg tct gcc cca tgg gag cga aga atc tcc agc cca gca gaa gag     1944
 Cys Leu Ser Ala Pro Trp Glu Arg Arg Ile Ser Ser Pro Ala Glu Glu
 590                 595                 600                 605

 acc tgg atc aca tgt gaa gat aga ata aga gtg cgt gga gga gac acc     1992
 Thr Trp Ile Thr Cys Glu Asp Arg Ile Arg Val Arg Gly Gly Asp Thr
                 610                 615                 620

 gag tgc tct ggg aga gtg gag atc tgg cac gca ggc tcc tgg ggc aca     2040
 Glu Cys Ser Gly Arg Val Glu Ile Trp His Ala Gly Ser Trp Gly Thr
             625                 630                 635

 gtg tgt gat gac tcc tgg gac ctg gcc gag gcg gaa gtg gtg tgt cag     2088
 Val Cys Asp Asp Ser Trp Asp Leu Ala Glu Ala Glu Val Val Cys Gln
         640                 645                 650

 cag ctg ggc tgt ggc tct gct ctg gct gcc ctg agg gac gct tcg ttt     2136
 Gln Leu Gly Cys Gly Ser Ala Leu Ala Ala Leu Arg Asp Ala Ser Phe
     655                 660                 665

 ggc cag gga act gga acc atc tgg ttg gat gac atg cgg tgc aaa gga     2184
 Gly Gln Gly Thr Gly Thr Ile Trp Leu Asp Asp Met Arg Cys Lys Gly
 670                 675                 680                 685

 aat gag tca ttt cta tgg gac tgt cac gcc aaa ccc tgg gga cag agt     2232
 Asn Glu Ser Phe Leu Trp Asp Cys His Ala Lys Pro Trp Gly Gln Ser
                 690                 695                 700

 gac tgt gga cac aag gaa gat gct ggc gtg agg tgc tct gga cag tcg     2280
 Asp Cys Gly His Lys Glu Asp Ala Gly Val Arg Cys Ser Gly Gln Ser
             705                 710                 715

 ctg aaa tca ctg aat gcc tcc tca ggt cat tta gca ctt att tta tcc     2328
 Leu Lys Ser Leu Asn Ala Ser Ser Gly His Leu Ala Leu Ile Leu Ser
         720                 725                 730

 agt atc ttt ggg ctc ctt ctc ctg gtt ctg ttt att cta ttt ctc acg     2376
 Ser Ile Phe Gly Leu Leu Leu Leu Val Leu Phe Ile Leu Phe Leu Thr
     735                 740                 745

 tgg tgc cga gtt cag aaa caa aaa cat ctg ccc ctc aga gtt tca acc     2424
 Trp Cys Arg Val Gln Lys Gln Lys His Leu Pro Leu Arg Val Ser Thr
 750                 755                 760                 765

 aga agg agg ggt tct ctc gag gag aat tta ttc cat gag atg gag acc     2472
 Arg Arg Arg Gly Ser Leu Glu Glu Asn Leu Phe His Glu Met Glu Thr
                 770                 775                 780

 tgc ctc aag aga gag gac cca cat ggg aca aga acc tca gat gac acc     2520
 Cys Leu Lys Arg Glu Asp Pro His Gly Thr Arg Thr Ser Asp Asp Thr
             785                 790                 795

 ccc aac cat ggt tgt gaa gat gct agc gac aca tcg ctg ttg gga gtt     2568
 Pro Asn His Gly Cys Glu Asp Ala Ser Asp Thr Ser Leu Leu Gly Val
         800                 805                 810

 ctt cct gcc tct gaa gcc aca aaa tgactttaga cttccagggc tcaccagatc    2622
 Leu Pro Ala Ser Glu Ala Thr Lys 
     815                 820

 aacctctaaa tatctttgaa ggagacaaca acttttaaat gaataaagag gaagtcaagt   2682

 tgccctatgg aaaacttgtc caaataacat ttcttgaaca ataggagaac agctaaattg   2742

 ataaagactg gtgataataa aaattgaatt atgtatatca ctgttaaaaa aaaaaaaa     2800




      <210> 35
      <211> 858
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(611)

      <400> 35
 agccgcgtga gatccgcgcg ggtgctagct agtcctttct cgtcgctgct cggctcgcgg     60

 cccgtggggt cggccccgcc accgttgccg cc  atg ccc atg aag ggc cgc ttc     113
                                      Met Pro Met Lys Gly Arg Phe
                                        1               5

 ccc atc cgc cgc acc ctg caa tat ctg agc cag ggg aac gtg gtg ttc      161
 Pro Ile Arg Arg Thr Leu Gln Tyr Leu Ser Gln Gly Asn Val Val Phe
          10                  15                  20

 aag gac tcc gtg aag gtc atg aca gtg aat tac aac acg cat ggg gag      209
 Lys Asp Ser Val Lys Val Met Thr Val Asn Tyr Asn Thr His Gly Glu
      25                  30                  35

 ctg ggc gag ggc gcc agg aag ttt gtg ttt ttc aac ata cct cag att      257
 Leu Gly Glu Gly Ala Arg Lys Phe Val Phe Phe Asn Ile Pro Gln Ile
  40                  45                  50                  55

 caa tac aaa aac cct tgg gtg cag atc atg atg ttt aag aac atg acg      305
 Gln Tyr Lys Asn Pro Trp Val Gln Ile Met Met Phe Lys Asn Met Thr
                  60                  65                  70

 ccg tca ccc ttc ctg cga ttc tac tta gat tct ggg gag cag gtc ctg      353
 Pro Ser Pro Phe Leu Arg Phe Tyr Leu Asp Ser Gly Glu Gln Val Leu
              75                  80                  85

 gtg gat gtg gag acc aag agc aat aag gag atc atg gag cac atc aga      401
 Val Asp Val Glu Thr Lys Ser Asn Lys Glu Ile Met Glu His Ile Arg
          90                  95                 100

 aaa atc ttg ggg aag aat gag gaa acc ctc agg gaa gag gag gag gag      449
 Lys Ile Leu Gly Lys Asn Glu Glu Thr Leu Arg Glu Glu Glu Glu Glu
     105                 110                 115

 aaa aag cag ctt tct cac cca gcc aac ttc ggc cct cga aag tac tgc      497
 Lys Lys Gln Leu Ser His Pro Ala Asn Phe Gly Pro Arg Lys Tyr Cys
 120                 125                 130                 135

 ctg cgg gag tgc atc tgt gaa gtg gaa ggg cag gtg ccc tgc ccc agc      545
 Leu Arg Glu Cys Ile Cys Glu Val Glu Gly Gln Val Pro Cys Pro Ser
                 140                 145                 150

 ctg gtg cca tta ccc aag gag atg agg ggg aag tac aaa gcc gct ttg      593
 Leu Val Pro Leu Pro Lys Glu Met Arg Gly Lys Tyr Lys Ala Ala Leu
             155                 160                 165

 aaa gcc gat gcc cag gac taaggc ccccggtccc tgtgggctgg ggtgatggtg      647
 Lys Ala Asp Ala Gln Asp 
         170

 tctgaccagt ggggagattg gaatgggatt actttggccc agggaagccc ctggttctgt    707

 ccctggagac tctggaaatc cttttgcatt aaaaggactt tacacacctg tgtaaaagga    767

 tgtgggagag gagggtctga agctgagctg ctaaatgaat atccctgctc tgctggtcaa    827

 taaaacgctt cctaatagca aaaaaaaaaa a                                   858




      <210> 36
      <211> 1131
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (336)..(632)

      <400> 36
 ctcccaaaat gttgggatta cagggacaag cctctgcacc tggccaagga ttgtttttta     60

 agtgagactg agacccagcc ttattagtgg tcccagagca gacctgggac ctgaagggaa    120

 cccttttctt ctggtccagc gtctttcctc tgatgggcta ctttcctgga gcctttgatt    180

 gcctgtcatc agagtaactg agtttgaaca gagtaggtaa ttcctctcca gaccaccaca    240

 ctcaccagct ttcattctgc ttctctcgtt tagactgtgg ttctgaatcc tcagttctat    300

 ttactgagtg tttttaaaca taaaaatgcc tttta   atg aga ttg aag gcc aga     353
                                          Met Arg Leu Lys Ala Arg
                                            1               5

 ggt ggg aca gtt gag gac aaa gta gaa ata aaa ccc tca agg cgg ggt      401
 Gly Gly Thr Val Glu Asp Lys Val Glu Ile Lys Pro Ser Arg Arg Gly
              10                  15                  20

 tgt tgg tgg gag tct ttt ttt gtt tgt ttg ttt ttt gag aca gag tct      449
 Cys Trp Trp Glu Ser Phe Phe Val Cys Leu Phe Phe Glu Thr Glu Ser
          25                  30                  35

 tac tct gtc atc cag gct gga gtg cag tgg cac aat ctc agc tca ctg      497
 Tyr Ser Val Ile Gln Ala Gly Val Gln Trp His Asn Leu Ser Ser Leu
      40                  45                  50

 caa cct ccg cct ccc gag ttc aag cta ttc tcc tgc ctc agc ctc ctt      545
 Gln Pro Pro Pro Pro Glu Phe Lys Leu Phe Ser Cys Leu Ser Leu Leu
  55                  60                  65                  70

 agt agc tgg gat ttc agg ctc ccg cca cca tgc cca gct aat ttt tgt      593
 Ser Ser Trp Asp Phe Arg Leu Pro Pro Pro Cys Pro Ala Asn Phe Cys
                  75                  80                  85

 att ttt agt aga gac agg gtt tca cca tgt tgg cca ggc tgatctcgaa       642
 Ile Phe Ser Arg Asp Arg Val Ser Pro Cys Trp Pro Gly 
              90                  95

 ctcctgagat cgggcagatt gcttgagccc aggagttcac aaccagcctg ggctggtaaa    702

 accccgtgtc tattaaaaaa acaaacaaaa aacaaacaat aagctagcag agtgtttcct    762

 gtttcaggcc tgctatgaga gaggcgagga agtcagtgta gtgcccaaaa catctgcttc    822

 cactgactcc ccctggatgg gtctcgcaaa atatgcctgg tctgggtatg tgatcgaatg    882

 tcctagctgt ggcgtggtct atcgtagtcg gcagtactgg tttggaaacc aagatcctgt    942

 ggatacggtg gtgcggacag agattgtgca tgtgtggcct ggaactgatg ggtttatgaa   1002

 ggacaacaac aatgctgccc agcgcctgtt ggacgggatg aacttcatgg ctcagtcggt   1062

 gtccgagctt agccttggac ccaccaaggc tgtgacttcc tggctgacag accagatcgc   1122

 ccatgtatt                                                           1131




      <210> 37
      <211> 2963
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(1157)

      <400> 37
 aaggatcctt aattaaatta atcccccccc cccgaaggaa tcaagccccc aag   atg      56
                                                              Met
                                                                1

 gcg gca gcg gcg gag gag cgg atg gca gag gaa gga ggc ggc ggc caa      104
 Ala Ala Ala Ala Glu Glu Arg Met Ala Glu Glu Gly Gly Gly Gly Gln
               5                  10                  15

 ggc gac ggc ggt tcc tct ttg gcc tcc ggc tct acc cag cga cag cct      152
 Gly Asp Gly Gly Ser Ser Leu Ala Ser Gly Ser Thr Gln Arg Gln Pro
          20                  25                  30

 cca ccg ccc gcg cca cag cac ccg cag ccg ggg tcc cag gcg ctc cca      200
 Pro Pro Pro Ala Pro Gln His Pro Gln Pro Gly Ser Gln Ala Leu Pro
      35                  40                  45

 gcc ccc gcg ctg gct ccg gac cag ctg cct caa aac aac acg ctt gtg      248
 Ala Pro Ala Leu Ala Pro Asp Gln Leu Pro Gln Asn Asn Thr Leu Val
  50                  55                  60                  65

 gcg ctg ccc atc gta gcc atc gag aac atc ctc agc ttt atg tcc tac      296
 Ala Leu Pro Ile Val Ala Ile Glu Asn Ile Leu Ser Phe Met Ser Tyr
                  70                  75                  80

 gac gaa att agc cag ctc cgc ctg gtt tgt aaa aga atg gac ttg gtc      344
 Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met Asp Leu Val
              85                  90                  95

 tgc cag aga atg ttg aat cag gga ttt ctg aaa gtg gag agg tac cat      392
 Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu Arg Tyr His
         100                 105                 110

 aat cta tgt cag aaa caa gtt aaa gca caa ctc cca agg aga gag tca      440
 Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg Arg Glu Ser
     115                 120                 125

 gaa agg aga aac cat tca tta gct cgt cat gca gac att ctt gct gct      488
 Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile Leu Ala Ala
 130                 135                 140                 145

 gtt gaa aca agg ctg tca cta tta aat atg act ttc atg aaa tat gtg      536
 Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met Lys Tyr Val
                 150                 155                 160

 gat tcc aat ctc tgt tgc ttc atc cca gga aag gtg att gat gag att      584
 Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Val Ile Asp Glu Ile
             165                 170                 175

 tat cgt gtg ttg aga tat gtc aat tct acc aga gcc cct caa cga gct      632
 Tyr Arg Val Leu Arg Tyr Val Asn Ser Thr Arg Ala Pro Gln Arg Ala
         180                 185                 190

 cat gaa gta ctt caa gaa tta agg gat ata tcc tct atg gca atg gag      680
 His Glu Val Leu Gln Glu Leu Arg Asp Ile Ser Ser Met Ala Met Glu
     195                 200                 205

 tac ttt gat gaa aag att gtt cca att tta aag agg aaa tta cca gga      728
 Tyr Phe Asp Glu Lys Ile Val Pro Ile Leu Lys Arg Lys Leu Pro Gly
 210                 215                 220                 225

 tca gat gtt tct gga aga ctc atg ggc tct cct cca gtt cca gga ccg      776
 Ser Asp Val Ser Gly Arg Leu Met Gly Ser Pro Pro Val Pro Gly Pro
                 230                 235                 240

 tct gca gcc cta aca aca atg cag ctc ttc tcc aag caa aat cct tca      824
 Ser Ala Ala Leu Thr Thr Met Gln Leu Phe Ser Lys Gln Asn Pro Ser
             245                 250                 255

 aga caa gag gtt acc aaa ctc cag cag cag gtt aaa aca aat ggt gct      872
 Arg Gln Glu Val Thr Lys Leu Gln Gln Gln Val Lys Thr Asn Gly Ala
         260                 265                 270

 ggc gtg act gtt ctc agg cgt gaa att tct gag ctt cgc acc aaa gtg      920
 Gly Val Thr Val Leu Arg Arg Glu Ile Ser Glu Leu Arg Thr Lys Val
     275                 280                 285

 caa gaa cag caa aaa cag ctt caa gac cag gac cag aaa ctg cta gag      968
 Gln Glu Gln Gln Lys Gln Leu Gln Asp Gln Asp Gln Lys Leu Leu Glu
 290                 295                 300                 305

 cag acc cag atc ata ggt gaa caa aat gca cgg ttg gca gag cta gaa     1016
 Gln Thr Gln Ile Ile Gly Glu Gln Asn Ala Arg Leu Ala Glu Leu Glu
                 310                 315                 320

 cgc aaa cta cga gaa gta atg gaa agt gct gta gga aat tcc tca ggg     1064
 Arg Lys Leu Arg Glu Val Met Glu Ser Ala Val Gly Asn Ser Ser Gly
             325                 330                 335

 tcc ggg cag aat gag gag tct cct cgg aaa cga aaa aag gcc acg gaa     1112
 Ser Gly Gln Asn Glu Glu Ser Pro Arg Lys Arg Lys Lys Ala Thr Glu
         340                 345                 350

 gcc ata gac tct ctt agg aaa tct aaa cgt ctt cgg aat aga aag taa     1160
 Ala Ile Asp Ser Leu Arg Lys Ser Lys Arg Leu Arg Asn Arg Lys 
     355                 360                 365

 attggaatgt ggttctagtt ccagaggaag acacagctta gtagcttaag cagttatgca   1220

 tatcaggata ctgtgagcaa catggtgtcc cttaagcttc taggctttca gaacacaact   1280

 taaacttgaa ctcttatggt tgggacattc ttttcctgct tctcctgatt gaactgatgc   1340

 acagaatctt tttactttgc aatagatttg tactaaccag acctgttcta tcatgttttg   1400

 aggagttaac ttttttctgt gcagataatg ttgaaagtaa gttaatttgt ttctgcatat   1460

 atgcacatac atacgtaagg atcttaaacc cagtcttgac agactagaag ttaagtttaa   1520

 tacagaaaat gtcctgttca cttgaaagaa aagacctact ttttaaatgg acactatctt   1580

 ggttcttttt tttttaagtc atctttttgt tataagtgac ctttgtctgg aatgtctgaa   1640

 aagtagttaa tgctttttgg tattgaagta atgggtaact aaaatggact tccatagtat   1700

 tgactgtaga aggagcctct acaatattga ctatatattt ttataaacta ctggcaagga   1760

 acttacccag ctgttataca tgttttcagt tctctttggg ggccatgtcc tacatttgca   1820

 tggatggatg catgcattgc ctagtcaact cacttaaaaa gctcttgcac tggtattgat   1880

 cttgaacctc tatacttctc cactttttag agcggcgtct tagtttattt aaacgcttaa   1940

 catcttccac cgcaacagct tgcctctaga gggggaattg ttcatccatt tgtcctccag   2000

 ttttatagga acaagagact attaaagccc attgctttat ctgctctctg tagggttcag   2060

 gtacactggc taaggcagaa ccccaaattt caaggctctt tctatcaata ttggacctct   2120

 gggagctaat actcctcttt gctcaccacc atgtgatcat tgatcagatg tggtgagtga   2180

 gtaggggact cgacttgcgg gatgcagttt tgccattgca gcaaagttca ttgaggaaaa   2240

 ttgtaccatg aaaaagcatt ttgattattt catttctgga ggatgacctt gagggaagct   2300

 ttttaatatt agtttcaagc tttccttacc ctacaacttt aaacaaaagc tttaattttg   2360

 tttgcactcc tattttgagc ttgtaactgg aaaagcatgt cttgcactgt tcaacctcct   2420

 gagtggtcgc tttaacaacc tccaaattgt gtacagtggt tattttcccc agttgtatag   2480

 ttttgagaca ttcaattatc actgtcttag ttgtatttta atttactaaa ttatgtagct   2540

 atttgactgt taagttcttt taaacaactg tttccttggg cttcagttat ttaaagtaaa   2600

 tttaggtgta atatagaaaa ctgtcccttt ccaggtggga gcttaacacc tgtataaaac   2660

 ctaaggtttt ggtaagtacc ttagttgaat aaaagcacaa ggttatcacc ttttttatcc   2720

 gtccaccgtg acatggttat gcatccttta gattaacctc accaaatgaa gctttttcta   2780

 tccattttta atattgtcct tacataatat tgtccttaga ttttgatcaa ttctatgtct   2840

 gactttgaaa ttccatttac aatgtagtat gttttcaatg aaaaaccata aagtaacatc   2900

 caagtgtttc atggtttgtt gggaaggtaa ttttaaaata aaacaatttc caaaaaaaaa   2960

 aaa                                                                 2963




      <210> 38
      <211> 782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(433)

      <400> 38
 cacatgccta tcatatagta aaacccagcc c   atg acc cct aac agg ggc cct      52
                                      Met Thr Pro Asn Arg Gly Pro
                                        1               5

 ctc agc cct cct aat gac ctc cgg cct agc cat gtg att tca ctt cca      100
 Leu Ser Pro Pro Asn Asp Leu Arg Pro Ser His Val Ile Ser Leu Pro
          10                  15                  20

 ctc cat aac gct cct cat act agg cct act aac caa cac act aac cat      148
 Leu His Asn Ala Pro His Thr Arg Pro Thr Asn Gln His Thr Asn His
      25                  30                  35

 ata cca atg atg gcg cga tgt aac acg aga aag cac ata cca agg cca      196
 Ile Pro Met Met Ala Arg Cys Asn Thr Arg Lys His Ile Pro Arg Pro
  40                  45                  50                  55

 cca cac acc acc tgt cca aaa agg cct tcg ata cgg gat aat cct att      244
 Pro His Thr Thr Cys Pro Lys Arg Pro Ser Ile Arg Asp Asn Pro Ile
                  60                  65                  70

 tat tac ctc aga agt ttt ttt ctt cgc agg att ttt ctg agc ctt tta      292
 Tyr Tyr Leu Arg Ser Phe Phe Leu Arg Arg Ile Phe Leu Ser Leu Leu
              75                  80                  85

 cca ctc cag cct agc ccc tac ccc cca att agg agg gca ctg gcc ccc      340
 Pro Leu Gln Pro Ser Pro Tyr Pro Pro Ile Arg Arg Ala Leu Ala Pro
          90                  95                 100

 aac agg cat cac ccc gct aaa tcc cct aga agt ccc act cct aaa cac      388
 Asn Arg His His Pro Ala Lys Ser Pro Arg Ser Pro Thr Pro Lys His
     105                 110                 115

 atc cgt att act cgc atc agg agt atc aat cac ctg agc tca cca tag      436
 Ile Arg Ile Thr Arg Ile Arg Ser Ile Asn His Leu Ser Ser Pro 
 120                 125                 130

 tctaatagaa aacaaccgaa accaaataat tcaagcactg cttattacaa ttttactggg    496

 tctctatttt accctcctac aagcctcaga gtacttcgag tctcccttca ccatttccga    556

 cggcatctac ggctcaacat tttttgtagc cacaggcttc cacggacttc acgtcattat    616

 tggctcaact ttcctcacta tctgcttcat ccgccaacta atatttcact ttacatccaa    676

 acatcacttt ggcttcgaag ccgccgcctg atactggcat tttgtagatg tggtttgact    736

 atttctgtat gtctccatct attgatgagg gtcttaaaaa aaaaaa                   782




      <210> 39
      <211> 1739
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (777)..(1025)

      <400> 39
 ctccggaatt cccgggacga aatcgtcgac agcgaagggt accctaaccg tgcaaaggta     60

 gcataatcac ttgttcctta attagggacc tgtatgaatg gctccacgag ggttcagctg    120

 tctcttactt ttaaccagtg aaattgacct gcccgtgaag aggcgggcat gacacagcaa    180

 gacgagaaga ccctatggag ctttaattta ttaatgcaaa cagtacctaa caaacccaca    240

 ggtcctaaac taccaaacct gcattaaaaa tttcggttgg ggcgacctcg gagcagaacc    300

 caacctccga gcagtacatg ctaagacttc accagtcaaa gcgaactact atactcaatt    360

 gatccaataa cttgaccaac ggaacaagtt accctaggga taacagcgca atcctattct    420

 agagtccata tcaacaatag ggtttacgac ctcgatgttg gatcaggaca tcccgatggt    480

 gcagccgcta ttaaaggttc gtttgttcaa cgattaaagt cctacgtgat ctgagttcag    540

 accggagtaa tccaggtcgg tttctatcta cttcaaattc ctccctgtac gaaaggacaa    600

 gagaaataag gcctacttca caaagcgcct tcccccgtaa atgatatcat ctcaacttag    660

 cattataccc acacccacct aagaacaggg tttgttaaga tggcagagcc cggtaatcgc    720

 ataaaactta aaactttaca gtcagaggtt caattcctct tcttaacaac ataccc        776                                                                 
 atg gcc aac ctc cta ctc ctc att gta ccc att cta atc gca atg gca      824
 Met Ala Asn Leu Leu Leu Leu Ile Val Pro Ile Leu Ile Ala Met Ala
   1               5                  10                  15

 ttc cta atg ctt acc gaa cga aaa att cta ggc tat ata caa cta cgc      872
 Phe Leu Met Leu Thr Glu Arg Lys Ile Leu Gly Tyr Ile Gln Leu Arg
              20                  25                  30

 aaa ggc ccc aac gtt gta ggc ccc tac ggg cta cta caa ccc ttc gct      920
 Lys Gly Pro Asn Val Val Gly Pro Tyr Gly Leu Leu Gln Pro Phe Ala
          35                  40                  45

 gac gcc ata aaa ctc ttc acc aaa gag ccc cta aaa gca gcc aca tct      968
 Asp Ala Ile Lys Leu Phe Thr Lys Glu Pro Leu Lys Ala Ala Thr Ser
      50                  55                  60

 acc atc acc ctc tac atc acc gcc ccg acc tta gct ctc acc atc gct     1016
 Thr Ile Thr Leu Tyr Ile Thr Ala Pro Thr Leu Ala Leu Thr Ile Ala
  65                  70                  75                  80

 ctt cta cta tgaaccc ccctcctcac acccaacccc ctggtcaacc tcaacctagg     1072
 Leu Leu Leu 


 cctcctattt attctagcca cctctagcct agccgtttac tcaatcctct gatcagggtg   1132

 agcatcaaac tcaaactacg ccctgatcgg cgcactgcga gcagtagccc aaacaatctc   1192

 atatgaagtc accctagcca tcattctact atcaacatta ctaataagtg gctcctttaa   1252

 cctctccacc cttatcacaa cacaagaaca cctctgatta ctcctgccat catgaccctt   1312

 ggccataata tgatttatct ccacactagc agagaccaac cgaaccccct tcgaccttgc   1372

 cgaaggggag tccgaactag tctcaggctt caacatcgaa tacgccgcag gccccttcgc   1432

 cctattcttc atagccgaat acacaaacat tattataata aacaccctca ccactacaat   1492

 cttcctagga acaacatatg acgcactctc ccctgaactc tacacaacat attttgtcac   1552

 caagacccta cttctaacct ccctgttctt atgaattcga acagcatacc cccgattccg   1612

 ctacgaccaa ctcatacacc tcctatgaaa aaacttccta ccactcaccc tagcattact   1672

 tatatgatat gtctccatac ccattacaat ctccagcatt ccccctcaaa cctaaaaaaa   1732

 aaaaaaa                                                             1739




      <210> 40
      <211> 2386
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (447)..(1691)

      <400> 40
 aagagggcca cgagctgcga aagggcggga aaggcagttg gagaagagaa atcttcccaa     60

 ggctgcagac accgacggat ttgctttggg agccagagta gctgccgcca ccagagtccg    120

 gagccatgag cgggtttaat tttggaggca ctggggcccc tacaggcggg ttcacgtttg    180

 gcactgcaaa gacggcaaca accacacctg ctacagggtt ttctttctcc acctctggca    240

 ctggagggtt taattttggg gctcccttcc aaccagccac aagtacccct tccaccggcc    300

 tgttctcact tgccacccag actccggcca cacagacgac aggcttcact tttggaacag    360

 cgactcttgc ttcgggggga actggatttt ctttggggat cggtgcttca aagctcaact    420

 tgagcaacac agctgccacc ccagcc atg gca aac ccc agc ggc ttt ggg ctg     473
                              Met Ala Asn Pro Ser Gly Phe Gly Leu
                                1               5

 ggc agc agc aac ctc act aat gcc ata tcg agc acc gtc acc tcc agc      521
 Gly Ser Ser Asn Leu Thr Asn Ala Ile Ser Ser Thr Val Thr Ser Ser
  10                  15                  20                  25

 cag ggc aca gca ccc acc ggc ttt gtg ttt ggc ccc tcc acc acc tct      569
 Gln Gly Thr Ala Pro Thr Gly Phe Val Phe Gly Pro Ser Thr Thr Ser
                  30                  35                  40

 gtg gct cca gct acc aca tct gga ggc ttc tca ttc act ggt gga agc      617
 Val Ala Pro Ala Thr Thr Ser Gly Gly Phe Ser Phe Thr Gly Gly Ser
              45                  50                  55

 acg gcc caa ccc tcc ggt ttc aac att ggc tca gca ggg aat tca gcc      665
 Thr Ala Gln Pro Ser Gly Phe Asn Ile Gly Ser Ala Gly Asn Ser Ala
          60                  65                  70

 cag ccc acg gca cct gcc acg ttg ccc ttc act ccg gcc acg cca gca      713
 Gln Pro Thr Ala Pro Ala Thr Leu Pro Phe Thr Pro Ala Thr Pro Ala
      75                  80                  85

 gcc acc aca gca ggt gcc aca cag cca gct gct ccc aca ccc aca gcc      761
 Ala Thr Thr Ala Gly Ala Thr Gln Pro Ala Ala Pro Thr Pro Thr Ala
  90                  95                 100                 105

 acc atc acc agt act ggg ccc agc ctc ttt gcg tca ata gca act gct      809
 Thr Ile Thr Ser Thr Gly Pro Ser Leu Phe Ala Ser Ile Ala Thr Ala
                 110                 115                 120

 cca acc tca tct gcc acc act gga ctc tcc ctc tgt acc cct gtg acc      857
 Pro Thr Ser Ser Ala Thr Thr Gly Leu Ser Leu Cys Thr Pro Val Thr
             125                 130                 135

 aca gcg ggc gcc ccc act gct ggg aca cag ggc ttc agc tta aag gca      905
 Thr Ala Gly Ala Pro Thr Ala Gly Thr Gln Gly Phe Ser Leu Lys Ala
         140                 145                 150

 cct gga gca gct tcc ggc acc tcc aca aca aca tcc acc gct gcc acc      953
 Pro Gly Ala Ala Ser Gly Thr Ser Thr Thr Thr Ser Thr Ala Ala Thr
     155                 160                 165

 gcc acc gcc acc acc acc acc agc agc agc acc acc ggc ttt gcc ttg     1001
 Ala Thr Ala Thr Thr Thr Thr Ser Ser Ser Thr Thr Gly Phe Ala Leu
 170                 175                 180                 185

 aat tta aaa cca ctg gcg cca gcc ggg atc ccc agc aat aca gca gct     1049
 Asn Leu Lys Pro Leu Ala Pro Ala Gly Ile Pro Ser Asn Thr Ala Ala
                 190                 195                 200

 gcc gtg acc gct cca cct ggc cct ggc gca gct gca ggg gcg gct gcc     1097
 Ala Val Thr Ala Pro Pro Gly Pro Gly Ala Ala Ala Gly Ala Ala Ala
             205                 210                 215

 agc tcc gcc atg acc tac gcg cag ctg gag agc ctg atc aac aaa tgg     1145
 Ser Ser Ala Met Thr Tyr Ala Gln Leu Glu Ser Leu Ile Asn Lys Trp
         220                 225                 230

 agc ctg gag cta gag gac cag gag cgg cac ttc ctc cag cag gcc acc     1193
 Ser Leu Glu Leu Glu Asp Gln Glu Arg His Phe Leu Gln Gln Ala Thr
     235                 240                 245

 cag gtc aac gcc tgg gac cgc acg ctg atc gag aat gga gaa aag atc     1241
 Gln Val Asn Ala Trp Asp Arg Thr Leu Ile Glu Asn Gly Glu Lys Ile
 250                 255                 260                 265

 acc agc ctg cac cgc gag gtg gag aag gtg aag ctg gac cag aag agg     1289
 Thr Ser Leu His Arg Glu Val Glu Lys Val Lys Leu Asp Gln Lys Arg
                 270                 275                 280

 ctg gac cag gag ctc gac ttc atc ctg tcc cag cag aag gag ctg gaa     1337
 Leu Asp Gln Glu Leu Asp Phe Ile Leu Ser Gln Gln Lys Glu Leu Glu
             285                 290                 295

 gac ctg ctg agc cca ctg gag gag ttg gtc aag gag cag agc ggg acc     1385
 Asp Leu Leu Ser Pro Leu Glu Glu Leu Val Lys Glu Gln Ser Gly Thr
         300                 305                 310

 atc tac ctg cag cac gcg gat gag gag cgt gag aaa acc tac aag ctg     1433
 Ile Tyr Leu Gln His Ala Asp Glu Glu Arg Glu Lys Thr Tyr Lys Leu
     315                 320                 325

 gct gag aac atc gac gca cag ctc aag cgc atg gcc cag gat ctc aag     1481
 Ala Glu Asn Ile Asp Ala Gln Leu Lys Arg Met Ala Gln Asp Leu Lys
 330                 335                 340                 345

 gac atc atc gag cac ctg aac acg tcc ggg gcc ccc gcc gac acc agt     1529
 Asp Ile Ile Glu His Leu Asn Thr Ser Gly Ala Pro Ala Asp Thr Ser
                 350                 355                 360

 gac cca ctg cag cag atc tgc aag atc ctc aat gcg cac atg gac tca     1577
 Asp Pro Leu Gln Gln Ile Cys Lys Ile Leu Asn Ala His Met Asp Ser
             365                 370                 375

 ctg cag tgg atc gac cag aac tcg gcc ctg ctg cag agg aag gtg gag     1625
 Leu Gln Trp Ile Asp Gln Asn Ser Ala Leu Leu Gln Arg Lys Val Glu
         380                 385                 390

 gag gtg acc aag gtg tgc gag ggc cgg cgc aag gag cag gag cgc agc     1673
 Glu Val Thr Lys Val Cys Glu Gly Arg Arg Lys Glu Gln Glu Arg Ser
     395                 400                 405

 ttc cgg atc acc ttt gac tgagcg acagcagccc tggggcccgc aggtccctag     1727
 Phe Arg Ile Thr Phe Asp 
 410                 415

 ggagttcatg aggggaatgc gccctgttgt ctgtagtttg gggttgtggc aagatacttg   1787

 tttgtttgtt tctttctttc acatgactgc ccttgacatg atcgctgtgt gctttgcgtt   1847

 tttccattta ggagggtatt ctgggccttc tgcccaggca gcagcctcat gggtgtggct   1907

 tctgtggctt tcatttgagt atctttggcc ccttttcacc tactgcgacc acccacctca   1967

 tcctggctca gcctggtgat ggagaagtgc tgatggtctt ggtcccagcc agggtcgtgg   2027

 gggcagccac tctctccaaa gcatagtcat gggtgtcatg aaaaaatacc aaatgtaaga   2087

 gaacctccaa gtcagggcgc agtggctcac ccctgtaatc tcagcacttt gggtggccaa   2147

 ggcgggcaga tgacttgagg tcaggagttc gagaccagcc tggccaacat ggtgaaaccc   2207

 cgtctctact aaaaatacaa aaattagtca ggtgtggtgg acgcctgtga tctcaatctc   2267

 agctactcgg gaggctgagg caggagaatc acttgaaccc aggaggtgtt gcagtgaacc   2327

 aagatcacac cactgcactc cagcctaggc aacagagact ctgtctcaaa aaaaaaaaa    2386




      <210> 41
      <211> 2303
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (29)..(2020)

      <400> 41
 cgcgggcacc cggcccccca gcgggagg   atg aag cgg cgg aac gcc gac tgc      52
                                  Met Lys Arg Arg Asn Ala Asp Cys
                                    1               5

 agt aag ctc cgc cgc ccc cta aag cgg aac cgg atc acc gag ggc att      100
 Ser Lys Leu Arg Arg Pro Leu Lys Arg Asn Arg Ile Thr Glu Gly Ile
      10                  15                  20

 tac ggc agt aca ttt tta tac ctg aaa ttc ctg gtg gtg tgg gca ctt      148
 Tyr Gly Ser Thr Phe Leu Tyr Leu Lys Phe Leu Val Val Trp Ala Leu
  25                  30                  35                  40

 gtc ctc cta gca gat ttt gtc ctg gag ttc aga ttt gaa tac ctg tgg      196
 Val Leu Leu Ala Asp Phe Val Leu Glu Phe Arg Phe Glu Tyr Leu Trp
                  45                  50                  55

 cca ttc tgg ctt ttc atc aga agc gtc tat gat tcc ttc aga tac cag      244
 Pro Phe Trp Leu Phe Ile Arg Ser Val Tyr Asp Ser Phe Arg Tyr Gln
              60                  65                  70

 gga ctg gcc ttc tca gta ttt ttt gtt tgt gta gca ttc acg tca aat      292
 Gly Leu Ala Phe Ser Val Phe Phe Val Cys Val Ala Phe Thr Ser Asn
          75                  80                  85

 ata ata tgc ctg ctg ttc atc ccc ata cag tgg ctt ttt ttt gct gct      340
 Ile Ile Cys Leu Leu Phe Ile Pro Ile Gln Trp Leu Phe Phe Ala Ala
      90                  95                 100

 agc aca tat gta tgg gtt cag tac gta tgg cac aca gaa agg gga gtg      388
 Ser Thr Tyr Val Trp Val Gln Tyr Val Trp His Thr Glu Arg Gly Val
 105                 110                 115                 120

 tgt ttg cct aca gtg tct ctc tgg atc ctc ttt gtt tat att gaa gca      436
 Cys Leu Pro Thr Val Ser Leu Trp Ile Leu Phe Val Tyr Ile Glu Ala
                 125                 130                 135

 gcc att aga ttt aaa gat ctc aaa aac ttt cat gta gac ctt tgt cgt      484
 Ala Ile Arg Phe Lys Asp Leu Lys Asn Phe His Val Asp Leu Cys Arg
             140                 145                 150

 cca ttt gct gct cac tgt att ggg tac cct gtg gta act ttg ggg ttt      532
 Pro Phe Ala Ala His Cys Ile Gly Tyr Pro Val Val Thr Leu Gly Phe
         155                 160                 165

 ggc ttc aaa agt tac gta agc tac aaa atg cgg tta agg aag caa aaa      580
 Gly Phe Lys Ser Tyr Val Ser Tyr Lys Met Arg Leu Arg Lys Gln Lys
     170                 175                 180

 gaa gta caa aaa gag aac gag ttt tac atg caa ctt ctt caa caa gct      628
 Glu Val Gln Lys Glu Asn Glu Phe Tyr Met Gln Leu Leu Gln Gln Ala
 185                 190                 195                 200

 ctc cct cca gag caa cag atg cta cag aag caa gaa aaa gag gcc gag      676
 Leu Pro Pro Glu Gln Gln Met Leu Gln Lys Gln Glu Lys Glu Ala Glu
                 205                 210                 215

 gaa gca gcc aaa gga tta cct gat atg gat tct tcg atc ctt ata cac      724
 Glu Ala Ala Lys Gly Leu Pro Asp Met Asp Ser Ser Ile Leu Ile His
             220                 225                 230

 cac aat gga ggt atc cca gcc aac aaa aaa ctc tcc aca act ttg cca      772
 His Asn Gly Gly Ile Pro Ala Asn Lys Lys Leu Ser Thr Thr Leu Pro
         235                 240                 245

 gag ata gaa tac cga gaa aaa ggg aaa gaa aag gac aag gat gcc aaa      820
 Glu Ile Glu Tyr Arg Glu Lys Gly Lys Glu Lys Asp Lys Asp Ala Lys
     250                 255                 260

 aaa cac aac ctt gga ata aat aac aac aat att cta caa cct gta gac      868
 Lys His Asn Leu Gly Ile Asn Asn Asn Asn Ile Leu Gln Pro Val Asp
 265                 270                 275                 280

 tct aaa ata caa gag att gag tat atg gaa aac cat atc aat agt aaa      916
 Ser Lys Ile Gln Glu Ile Glu Tyr Met Glu Asn His Ile Asn Ser Lys
                 285                 290                 295

 aga tta aat aat gat ctt gtg gga agt aca gaa aat ctc ttg aaa gag      964
 Arg Leu Asn Asn Asp Leu Val Gly Ser Thr Glu Asn Leu Leu Lys Glu
             300                 305                 310

 gac tca tgc act gct tcc tca aaa aat tac aaa aat gcc agt gga gtt     1012
 Asp Ser Cys Thr Ala Ser Ser Lys Asn Tyr Lys Asn Ala Ser Gly Val
         315                 320                 325

 gtg aac tct tca cct cga agt cat agc gcc aca aat ggg agc att cct     1060
 Val Asn Ser Ser Pro Arg Ser His Ser Ala Thr Asn Gly Ser Ile Pro
     330                 335                 340

 tcc tca tct agt aaa aat gag aag aag cag aaa tgc act agc aag agc     1108
 Ser Ser Ser Ser Lys Asn Glu Lys Lys Gln Lys Cys Thr Ser Lys Ser
 345                 350                 355                 360

 cca agt aca cac aag gac tta atg gaa aac tgt att cct aat aac cag     1156
 Pro Ser Thr His Lys Asp Leu Met Glu Asn Cys Ile Pro Asn Asn Gln
                 365                 370                 375

 cta agc aaa cca gac gca ctg gtc agg ctg gaa caa gac att aaa aag     1204
 Leu Ser Lys Pro Asp Ala Leu Val Arg Leu Glu Gln Asp Ile Lys Lys
             380                 385                 390

 tta aag gct gac ctg caa gcc agc aga caa gtg gaa caa gag ctc cgc     1252
 Leu Lys Ala Asp Leu Gln Ala Ser Arg Gln Val Glu Gln Glu Leu Arg
         395                 400                 405

 agt cag atc agc tcc ctt tcg agc acc gag cga ggg atc cgc tca gaa     1300
 Ser Gln Ile Ser Ser Leu Ser Ser Thr Glu Arg Gly Ile Arg Ser Glu
     410                 415                 420

 atg ggc cag ctt cgg cag gag aac gag ctg ctg cag aac aag tta cat     1348
 Met Gly Gln Leu Arg Gln Glu Asn Glu Leu Leu Gln Asn Lys Leu His
 425                 430                 435                 440

 aat gct gtg caa atg aag caa aaa gac aag cag aat atc agc cag ttg     1396
 Asn Ala Val Gln Met Lys Gln Lys Asp Lys Gln Asn Ile Ser Gln Leu
                 445                 450                 455

 gag aaa aag cta aaa gct gag cag gaa gcc cga agt ttt gta gag aaa     1444
 Glu Lys Lys Leu Lys Ala Glu Gln Glu Ala Arg Ser Phe Val Glu Lys
             460                 465                 470

 cag tta atg gaa gag aaa aag agg aag aag tta gaa gaa gcc act gct     1492
 Gln Leu Met Glu Glu Lys Lys Arg Lys Lys Leu Glu Glu Ala Thr Ala
         475                 480                 485

 gcc cgg gct gtt gcg ttt gct gct gca tct agg gga gaa tgc acc gaa     1540
 Ala Arg Ala Val Ala Phe Ala Ala Ala Ser Arg Gly Glu Cys Thr Glu
     490                 495                 500

 acc tta cgg aat cgg atc aga gaa cta gaa gca gag ggc aag aag ctc     1588
 Thr Leu Arg Asn Arg Ile Arg Glu Leu Glu Ala Glu Gly Lys Lys Leu
 505                 510                 515                 520

 acg atg gac atg aag gtg aaa gaa gac caa atc aga gaa cta gaa cta     1636
 Thr Met Asp Met Lys Val Lys Glu Asp Gln Ile Arg Glu Leu Glu Leu
                 525                 530                 535

 aaa gtc cag gag ctt cgg aaa tat aag gaa aat gag aag gac act gag     1684
 Lys Val Gln Glu Leu Arg Lys Tyr Lys Glu Asn Glu Lys Asp Thr Glu
             540                 545                 550

 gtg tta atg tca gcc ctc tca gcc atg caa gac aaa aca cag cac ctg     1732
 Val Leu Met Ser Ala Leu Ser Ala Met Gln Asp Lys Thr Gln His Leu
         555                 560                 565

 gag aac agc tta agt gca gag acg aga atc aag ctg gac ctg ttc tcc     1780
 Glu Asn Ser Leu Ser Ala Glu Thr Arg Ile Lys Leu Asp Leu Phe Ser
     570                 575                 580

 gca ctg ggc gat gca aag cgg cag ctc gag att gcc caa gga caa atc     1828
 Ala Leu Gly Asp Ala Lys Arg Gln Leu Glu Ile Ala Gln Gly Gln Ile
 585                 590                 595                 600

 ctt cag aaa gat cag gaa atc aag gac cta aaa cag aag ata gcc gaa     1876
 Leu Gln Lys Asp Gln Glu Ile Lys Asp Leu Lys Gln Lys Ile Ala Glu
                 605                 610                 615

 gtc atg gcc gtc atg ccc agc ata aca tac agt gcc gcc acc agc ccc     1924
 Val Met Ala Val Met Pro Ser Ile Thr Tyr Ser Ala Ala Thr Ser Pro
             620                 625                 630

 ctg agc cct gtt tcc ccc cac tac tct tcc aaa ttt gtg gag acc agc     1972
 Leu Ser Pro Val Ser Pro His Tyr Ser Ser Lys Phe Val Glu Thr Ser
         635                 640                 645

 ccc tct gga ctt gac ccc aat gcc tct gtt tac cag ccc ctg aag aaa     2020
 Pro Ser Gly Leu Asp Pro Asn Ala Ser Val Tyr Gln Pro Leu Lys Lys 
     650                 655                 660

 tgaaggccag ctgtgtgttg tgcccaaaaa tttggttacc ggaaggcatt gcaaaggagc   2080

 gtctctggca gtcaagataa aaaaacagtt tctattgtat tttgtggaac tgtatctgtt   2140

 gtcattttta aaaagggggg aaaagataac atccaagtct gattagaact gcccatcagt   2200

 ttttcttgta aatttttaga agacctcaca gaactttaca gtttattttt ctcggccaac   2260

 acattaaaac cattcttgga tttcaagtag caaaaaaaaa aaa                     2303




      <210> 42
      <211> 1309
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(948)

      <400> 42
 gggcaggctc taaaaaccct ggaagcgttg cttcttttgg caggaatggg ggttagcagg     60

 acctcaatgg ctcactatgg ctaagtgaac gctgactggg tcctccagcg tgagctagaa    120

 cagacgtctc tatggtcaag taaacagcgc gcgtgctgtc tttcccatgt ggtggggttg    180

 cgc  atg atc agt agc tgc acc act aga aag atg gcg gag gaa gag caa     228
      Met Ile Ser Ser Cys Thr Thr Arg Lys Met Ala Glu Glu Glu Gln
        1               5                  10                  15

 aga aaa atc cct ttg gtt cca gaa aat ctc ctg aaa aag agg aag gct      276
 Arg Lys Ile Pro Leu Val Pro Glu Asn Leu Leu Lys Lys Arg Lys Ala
                  20                  25                  30

 tat cag gca ctc aaa gcc acc cag gca aag cag gca ctt ttg gca aag      324
 Tyr Gln Ala Leu Lys Ala Thr Gln Ala Lys Gln Ala Leu Leu Ala Lys
              35                  40                  45

 aag gag cag aag aaa gga aaa ggg ctc agg ttt aag cga ctg gaa tca      372
 Lys Glu Gln Lys Lys Gly Lys Gly Leu Arg Phe Lys Arg Leu Glu Ser
          50                  55                  60

 ttc cta cat gat tcc tgg cgg cag aaa cgt gac aag gtg cgt ctc aga      420
 Phe Leu His Asp Ser Trp Arg Gln Lys Arg Asp Lys Val Arg Leu Arg
      65                  70                  75

 cga cta gaa gtg aaa cct cat gcc ttg gaa ttg cca gat aaa cat tcc      468
 Arg Leu Glu Val Lys Pro His Ala Leu Glu Leu Pro Asp Lys His Ser
  80                  85                  90                  95

 ttg gcc ttt gtt gta cgc atc gaa agg att gac ggc gtg agt tta ctg      516
 Leu Ala Phe Val Val Arg Ile Glu Arg Ile Asp Gly Val Ser Leu Leu
                 100                 105                 110

 gtg cag aga acc att gca aga ctt cgc cta aag aaa att ttt agt ggt      564
 Val Gln Arg Thr Ile Ala Arg Leu Arg Leu Lys Lys Ile Phe Ser Gly
             115                 120                 125

 gtc ttt gta aaa gtc acc ccc cag aat cta aaa atg ctg cgt ata gtg      612
 Val Phe Val Lys Val Thr Pro Gln Asn Leu Lys Met Leu Arg Ile Val
         130                 135                 140

 gaa cct tat gtg acc tgg gga ttt cca aat ctg aag tct gtc cga gaa      660
 Glu Pro Tyr Val Thr Trp Gly Phe Pro Asn Leu Lys Ser Val Arg Glu
     145                 150                 155

 ctc att ttg aaa cgt gga caa gcc aag gtc aag aat aag acc atc cct      708
 Leu Ile Leu Lys Arg Gly Gln Ala Lys Val Lys Asn Lys Thr Ile Pro
 160                 165                 170                 175

 ctg aca gac aat aca gtg att gag gag cac ctg ggg aag ttt ggc gtc      756
 Leu Thr Asp Asn Thr Val Ile Glu Glu His Leu Gly Lys Phe Gly Val
                 180                 185                 190

 att tgc ttg gaa gac ctc att cat gaa att gcc ttc cca ggg aag cat      804
 Ile Cys Leu Glu Asp Leu Ile His Glu Ile Ala Phe Pro Gly Lys His
             195                 200                 205

 ttc cag gag atc tca tgg ttc ttg tgc cct ttc cac ctc tca gtg gcc      852
 Phe Gln Glu Ile Ser Trp Phe Leu Cys Pro Phe His Leu Ser Val Ala
         210                 215                 220

 cgt cat gct acc aaa aat aga gtg ggc ttc ctc aag gag atg ggc aca      900
 Arg His Ala Thr Lys Asn Arg Val Gly Phe Leu Lys Glu Met Gly Thr
     225                 230                 235

 cct ggc tat cgg ggt gaa cgc atc aat cag ctc atc cgt cag ctg aac      948
 Pro Gly Tyr Arg Gly Glu Arg Ile Asn Gln Leu Ile Arg Gln Leu Asn 
 240                 245                 250                 255

 tagacccagg tgccaaactg cggtaaattt tttatcagtg aagtggaagc atgtgttttg   1008

 ttttggaaat ttttatcaag tatcttcaga gaagattatt tcctgcttta tcttcagaaa   1068

 ctggaaaggg tcaaagaaaa gacagtagct ggccggtcgt ggtggctcat gcctgtaatc   1128

 ccaacactta gggaggctga ggtgggcaga tcacctgagg ttgggagttc gagaccagcc   1188

 tgaccaacat ggagaaatgc catctctact aaaaatacaa aaattagccg ggcatggtgg   1248

 cacgtgcctg taatcccagc tactcaggag gctgaggcaa gagaattcct ttgaccttgg   1308

 g                                                                   1309




      <210> 43
      <211> 1989
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(1855)

      <400> 43
 cgtcggggct ggagcg    atg gcg gcg acc gcg gtg gcg gcg gct gtg gcg      49
                      Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala
                        1               5                  10

 gga acc gag tcg gcc cag ggt ccc ccg ggc ccg gca gcg tcg ctg gag       97
 Gly Thr Glu Ser Ala Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu
              15                  20                  25

 ctg tgg ctg aac aaa gcc aca gac cca agc atg tcg gaa cag gat tgg      145
 Leu Trp Leu Asn Lys Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp
          30                  35                  40

 tca gct atc cag aat ttc tgt gag cag gtg aac act gac ccc aat ggc      193
 Ser Ala Ile Gln Asn Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly
      45                  50                  55

 ccc aca cat gcg ccc tgg cta ctg gcc cac aag atc cag tct ccg caa      241
 Pro Thr His Ala Pro Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln
  60                  65                  70                  75

 gag aag gaa gct ctt tat gcc tta acg gtg ctg gag atg tgc atg aac      289
 Glu Lys Glu Ala Leu Tyr Ala Leu Thr Val Leu Glu Met Cys Met Asn
                  80                  85                  90

 cac tgt ggg gag aag ttc cac agc gag gtg gcc aaa ttt cgt ttc ctg      337
 His Cys Gly Glu Lys Phe His Ser Glu Val Ala Lys Phe Arg Phe Leu
              95                 100                 105

 aac gaa ctg atc aaa gtg ttg tcc cca aag tac ctg ggg tcc tgg gcc      385
 Asn Glu Leu Ile Lys Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp Ala
         110                 115                 120

 aca gga aaa gtt aaa gga aga gtc att gaa ata ctc ttc agt tgg aca      433
 Thr Gly Lys Val Lys Gly Arg Val Ile Glu Ile Leu Phe Ser Trp Thr
     125                 130                 135

 gtc tgg ttt ccg gaa gac atc aag att cga gac gct tat cag atg ctg      481
 Val Trp Phe Pro Glu Asp Ile Lys Ile Arg Asp Ala Tyr Gln Met Leu
 140                 145                 150                 155

 aag aaa caa gga att ata aaa caa gac cct aaa cta cca gtg gat aaa      529
 Lys Lys Gln Gly Ile Ile Lys Gln Asp Pro Lys Leu Pro Val Asp Lys
                 160                 165                 170

 atc tta ccc cca cca tct ccc tgg ccc aag agc tcc atc ttt gat gct      577
 Ile Leu Pro Pro Pro Ser Pro Trp Pro Lys Ser Ser Ile Phe Asp Ala
             175                 180                 185

 gat gaa gaa aag tcc aag ctt ctg aca agg ctt cta aag agc aac cac      625
 Asp Glu Glu Lys Ser Lys Leu Leu Thr Arg Leu Leu Lys Ser Asn His
         190                 195                 200

 ccc gag gac ctt cag gct gca aac cgg tta atc aag aat ttg gtc aag      673
 Pro Glu Asp Leu Gln Ala Ala Asn Arg Leu Ile Lys Asn Leu Val Lys
     205                 210                 215

 gag gaa caa gaa aaa tcg gag aag gtg tcc aag agg gtc agt gcg gtg      721
 Glu Glu Gln Glu Lys Ser Glu Lys Val Ser Lys Arg Val Ser Ala Val
 220                 225                 230                 235

 gag gaa gtg cga agc cat gtg aag gtg ctg cag gag atg ctg agc atg      769
 Glu Glu Val Arg Ser His Val Lys Val Leu Gln Glu Met Leu Ser Met
                 240                 245                 250

 tac cgc agg cca ggg cag gcc ccg ccc gac cag gag gcc ctg cag gtc      817
 Tyr Arg Arg Pro Gly Gln Ala Pro Pro Asp Gln Glu Ala Leu Gln Val
             255                 260                 265

 gtg tat gag agg tgt gaa aag ctg cgg ccc acg ctg ttc cgg ttg gcg      865
 Val Tyr Glu Arg Cys Glu Lys Leu Arg Pro Thr Leu Phe Arg Leu Ala
         270                 275                 280

 agt gac acc act gat gac gat gat gca ctc gcg gaa att ctc cag gca      913
 Ser Asp Thr Thr Asp Asp Asp Asp Ala Leu Ala Glu Ile Leu Gln Ala
     285                 290                 295

 aat gac ctc ctc acc caa gga gtt ctg ctg tac aaa cag gtg atg gag      961
 Asn Asp Leu Leu Thr Gln Gly Val Leu Leu Tyr Lys Gln Val Met Glu
 300                 305                 310                 315

 ggc cgg gtc acc ttt gga aac aga gtg acc agc tca ttg gga gac atc     1009
 Gly Arg Val Thr Phe Gly Asn Arg Val Thr Ser Ser Leu Gly Asp Ile
                 320                 325                 330

 cct gtc tcc aga gtc ttt cag aat cca gca ggc tgc atg aag acc tgc     1057
 Pro Val Ser Arg Val Phe Gln Asn Pro Ala Gly Cys Met Lys Thr Cys
             335                 340                 345

 ccc ctg att gac ttg gag gtg gac aat gga cct gcg cag atg ggg act     1105
 Pro Leu Ile Asp Leu Glu Val Asp Asn Gly Pro Ala Gln Met Gly Thr
         350                 355                 360

 gtg gtg cca tct ttg ctt cat cag gac ctg gca gcc ttg gga atc agt     1153
 Val Val Pro Ser Leu Leu His Gln Asp Leu Ala Ala Leu Gly Ile Ser
     365                 370                 375

 gat gct cct gtt aca ggc atg gtt tct ggt cag aat tgc tgt gag gaa     1201
 Asp Ala Pro Val Thr Gly Met Val Ser Gly Gln Asn Cys Cys Glu Glu
 380                 385                 390                 395

 aag agg aat ccc tcc tcc agc acg ctg cca ggc ggt ggt gtt cag aac     1249
 Lys Arg Asn Pro Ser Ser Ser Thr Leu Pro Gly Gly Gly Val Gln Asn
                 400                 405                 410

 cct tct gca gac agg aat ttg ctg gac ctc ctc tca cca cag cca gct     1297
 Pro Ser Ala Asp Arg Asn Leu Leu Asp Leu Leu Ser Pro Gln Pro Ala
             415                 420                 425

 ccg tgc cct ctg aat tat gtt tcg cag aaa agt gtc ccc aag gaa gtg     1345
 Pro Cys Pro Leu Asn Tyr Val Ser Gln Lys Ser Val Pro Lys Glu Val
         430                 435                 440

 cca cca ggt act aag tcc tct cca ggt tgg tcc tgg gag gct ggc ccg     1393
 Pro Pro Gly Thr Lys Ser Ser Pro Gly Trp Ser Trp Glu Ala Gly Pro
     445                 450                 455

 ttg gct cct tcc cca tct tca cag aat aca cct ctg gct caa gtg ttt     1441
 Leu Ala Pro Ser Pro Ser Ser Gln Asn Thr Pro Leu Ala Gln Val Phe
 460                 465                 470                 475

 gtc cct ttg gag tct gtt aag ccc agc agc ctg ccg cct ctc att gtg     1489
 Val Pro Leu Glu Ser Val Lys Pro Ser Ser Leu Pro Pro Leu Ile Val
                 480                 485                 490

 tat gac cgg aat gga ttc aga att ctg ctc cac ttc tcc cag acg gga     1537
 Tyr Asp Arg Asn Gly Phe Arg Ile Leu Leu His Phe Ser Gln Thr Gly
             495                 500                 505

 gcc cct ggg cac cca gag gta cag gtg ctg ctc ttg acc atg atg agc     1585
 Ala Pro Gly His Pro Glu Val Gln Val Leu Leu Leu Thr Met Met Ser
         510                 515                 520

 acg gct ccc cag cct gtc tgg gat atc atg ttt caa gtg gct gtg cca     1633
 Thr Ala Pro Gln Pro Val Trp Asp Ile Met Phe Gln Val Ala Val Pro
     525                 530                 535

 aag tca atg aga gtg aag ctg cag ccg gca tcc agc tcc aag ctt cct     1681
 Lys Ser Met Arg Val Lys Leu Gln Pro Ala Ser Ser Ser Lys Leu Pro
 540                 545                 550                 555

 gca ttc agt cct ttg atg cct cca gct gtg ata tct cag atg ctg ctg     1729
 Ala Phe Ser Pro Leu Met Pro Pro Ala Val Ile Ser Gln Met Leu Leu
                 560                 565                 570

 ctt gac aat cca cac aaa gaa cct atc cgc tta cgg tac aag ctg aca     1777
 Leu Asp Asn Pro His Lys Glu Pro Ile Arg Leu Arg Tyr Lys Leu Thr
             575                 580                 585

 ttc aac caa ggt gga cag cct ttc agc gaa gta gga gaa gtg aaa gac     1825
 Phe Asn Gln Gly Gly Gln Pro Phe Ser Glu Val Gly Glu Val Lys Asp
         590                 595                 600

 ttc cca gac ctg gct gtc ttg ggc gca gcc t aacttttcac aagatggacc     1876
 Phe Pro Asp Leu Ala Val Leu Gly Ala Ala 
     605                 610

 cttcatttca agcttaggct ggcgttactt ttgctgtcta gtcaggacta atcacggtgt   1936

 ttcagtgcgg agtgccaaga gtcctatcct gacgtcaaaa aaaaaaaaaa aaa          1989




      <210> 44
      <211> 1089
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(1057)

      <400> 44
 cgcgtgggcg gacgcgtggg cgcgcgccgg aagtacctac ctgggataac ggcggcgagc     60

 ggacggctgc atttacgggg tctcccggag ggccagagtc gtggcttaca gaagagacga    120

 a    atg tgg tct gag gga cga tat gaa tat gaa aga att ccg aga gaa     166
      Met Trp Ser Glu Gly Arg Tyr Glu Tyr Glu Arg Ile Pro Arg Glu
        1               5                  10                  15

 cga gca cct cct cga agt cat ccc agt gat gaa tct ggt tat aga tgg      214
 Arg Ala Pro Pro Arg Ser His Pro Ser Asp Glu Ser Gly Tyr Arg Trp
                  20                  25                  30

 aca aga gac gat cat tct gca agc agg caa cct gaa tac agg gac atg      262
 Thr Arg Asp Asp His Ser Ala Ser Arg Gln Pro Glu Tyr Arg Asp Met
              35                  40                  45

 aga gat ggc ttt aga aga aaa agt ttc tac tct tcc cat tat gcg aga      310
 Arg Asp Gly Phe Arg Arg Lys Ser Phe Tyr Ser Ser His Tyr Ala Arg
          50                  55                  60

 gag cgg tct cct tat aaa agg gac aat act ttt ttc aga gaa tca cct      358
 Glu Arg Ser Pro Tyr Lys Arg Asp Asn Thr Phe Phe Arg Glu Ser Pro
      65                  70                  75

 gtt ggc cga aag gat tct cca cac agc aga tct ggt tcc agt gtc agt      406
 Val Gly Arg Lys Asp Ser Pro His Ser Arg Ser Gly Ser Ser Val Ser
  80                  85                  90                  95

 agc aga agc tac tct cca gaa agg agc aaa tca tac tct ttc cat cag      454
 Ser Arg Ser Tyr Ser Pro Glu Arg Ser Lys Ser Tyr Ser Phe His Gln
                 100                 105                 110

 tct caa cat aga aag tcc gtg cgt cct ggt gcc tcc tac aaa cgg cag      502
 Ser Gln His Arg Lys Ser Val Arg Pro Gly Ala Ser Tyr Lys Arg Gln
             115                 120                 125

 aat gaa gga aat cct gaa aga gat aaa gag agg cct gtc cag tct ttg      550
 Asn Glu Gly Asn Pro Glu Arg Asp Lys Glu Arg Pro Val Gln Ser Leu
         130                 135                 140

 aaa aca tca aga gat act tca ccc tca agt ggt tca gca gtt tct tca      598
 Lys Thr Ser Arg Asp Thr Ser Pro Ser Ser Gly Ser Ala Val Ser Ser
     145                 150                 155

 tca aag gtg tta gac aaa ccc agt agg cta act gaa aag gaa ctt gct      646
 Ser Lys Val Leu Asp Lys Pro Ser Arg Leu Thr Glu Lys Glu Leu Ala
 160                 165                 170                 175

 gag gct gca agc aag tgg gct gct gaa aag cta gag aaa tca gat gaa      694
 Glu Ala Ala Ser Lys Trp Ala Ala Glu Lys Leu Glu Lys Ser Asp Glu
                 180                 185                 190

 agt aac ttg cct gaa att tct gag tat gag gcg gga tcc aca gca cca      742
 Ser Asn Leu Pro Glu Ile Ser Glu Tyr Glu Ala Gly Ser Thr Ala Pro
             195                 200                 205

 ttg ttt act gac cag cca gag gaa cct gag tca aac aca aca cat ggg      790
 Leu Phe Thr Asp Gln Pro Glu Glu Pro Glu Ser Asn Thr Thr His Gly
         210                 215                 220

 ata gaa tta ttt gaa gat agt cag cta acc act cgc tct aaa gca ata      838
 Ile Glu Leu Phe Glu Asp Ser Gln Leu Thr Thr Arg Ser Lys Ala Ile
     225                 230                 235

 gca tca aaa acc aaa gag att gaa cag gtt tac cga caa gac tgt gaa      886
 Ala Ser Lys Thr Lys Glu Ile Glu Gln Val Tyr Arg Gln Asp Cys Glu
 240                 245                 250                 255

 act ttc ggg atg gtg gtg aaa atg ctg att gaa aaa gat cct tca tta      934
 Thr Phe Gly Met Val Val Lys Met Leu Ile Glu Lys Asp Pro Ser Leu
                 260                 265                 270

 gaa aag tct ata cag ttt gca ttg agg cag aat tta cat gaa ata ggt      982
 Glu Lys Ser Ile Gln Phe Ala Leu Arg Gln Asn Leu His Glu Ile Gly
             275                 280                 285

 gag cgg tgt gtt gaa gaa ctc aag cat ttc att gca gag tat gat act     1030
 Glu Arg Cys Val Glu Glu Leu Lys His Phe Ile Ala Glu Tyr Asp Thr
         290                 295                 300

 tcc act caa gat ttt gga gag cct ttt tagat ttttctgctc aggctaaaaa     1082
 Ser Thr Gln Asp Phe Gly Glu Pro Phe 
     305                 310

 aaaaaaa                                                             1089




      <210> 45
      <211> 2011
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(1812)

      <400> 45
 gttgtattag atggaggatg tgacatttca gataaaaagc ttacaacttt aaaggataga     60

 gctagagaga agatccag  atg gcc cat tcc ctt tct gtt ggt ggg agt ggg     111
                      Met Ala His Ser Leu Ser Val Gly Gly Ser Gly
                        1               5                  10

 tac gta tgt ccc tta ctc atc cgg gaa gta ttc ata cag gtt ttg atc      159
 Tyr Val Cys Pro Leu Leu Ile Arg Glu Val Phe Ile Gln Val Leu Ile
              15                  20                  25

 aag ctg cgg gtg tgt ttt gtc cag tgc ttt tca gaa gca gat cgg gac      207
 Lys Leu Arg Val Cys Phe Val Gln Cys Phe Ser Glu Ala Asp Arg Asp
          30                  35                  40

 att atg aca ctt gct aac cat tgg aat tgc cct gtg tta tca tca gat      255
 Ile Met Thr Leu Ala Asn His Trp Asn Cys Pro Val Leu Ser Ser Asp
      45                  50                  55

 agt gac ttt tgc att ttt gac ctg aaa act ggg ttt tgc cca ttg aat      303
 Ser Asp Phe Cys Ile Phe Asp Leu Lys Thr Gly Phe Cys Pro Leu Asn
  60                  65                  70                  75

 agc ttt cag tgg aga aat atg aac act att aag ggc aca caa aac tat      351
 Ser Phe Gln Trp Arg Asn Met Asn Thr Ile Lys Gly Thr Gln Asn Tyr
                  80                  85                  90

 atc cct gcc aaa tgc ttt tcc ctt gat gca ttc tgc cat cac ttc agc      399
 Ile Pro Ala Lys Cys Phe Ser Leu Asp Ala Phe Cys His His Phe Ser
              95                 100                 105

 aat atg aat aaa gct cta cta cct ctc ttt gcg gtg cta tgt gga aat      447
 Asn Met Asn Lys Ala Leu Leu Pro Leu Phe Ala Val Leu Cys Gly Asn
         110                 115                 120

 gac cat gtt aat cta ccc atc atg gag aca ttc tta agt aaa gcg cgt      495
 Asp His Val Asn Leu Pro Ile Met Glu Thr Phe Leu Ser Lys Ala Arg
     125                 130                 135

 ctt cct ctt gga gct acc agt tct aaa ggg agg aga cac cac cga atc      543
 Leu Pro Leu Gly Ala Thr Ser Ser Lys Gly Arg Arg His His Arg Ile
 140                 145                 150                 155

 ctg gga ctt ctg aat tgg ttg tct cat ttt gcc aac cct acc gaa gca      591
 Leu Gly Leu Leu Asn Trp Leu Ser His Phe Ala Asn Pro Thr Glu Ala
                 160                 165                 170

 cta gat aat gtt ctg aaa tac ctc cca aaa aag gat cga gaa aat gtt      639
 Leu Asp Asn Val Leu Lys Tyr Leu Pro Lys Lys Asp Arg Glu Asn Val
             175                 180                 185

 aag gaa ctt ctc tgc tgt tcc atg gaa gaa tac caa cag tcc cag gtg      687
 Lys Glu Leu Leu Cys Cys Ser Met Glu Glu Tyr Gln Gln Ser Gln Val
         190                 195                 200

 aag cta cag gac ttc ttc cag tgt ggt act tat gtc tgt cca gat gcc      735
 Lys Leu Gln Asp Phe Phe Gln Cys Gly Thr Tyr Val Cys Pro Asp Ala
     205                 210                 215

 ttg aat ctt ggt tta cca gaa tgg gta tta gtg gct tta gct aaa ggc      783
 Leu Asn Leu Gly Leu Pro Glu Trp Val Leu Val Ala Leu Ala Lys Gly
 220                 225                 230                 235

 cag cta tct cct ttc atc agt gat gct ttg gtc cta aga cgg acc att      831
 Gln Leu Ser Pro Phe Ile Ser Asp Ala Leu Val Leu Arg Arg Thr Ile
                 240                 245                 250

 ctt ccc aca cag gtg gaa aac atg cag caa cca aat gcc cac aga ata      879
 Leu Pro Thr Gln Val Glu Asn Met Gln Gln Pro Asn Ala His Arg Ile
             255                 260                 265

 tct cag ccc atc agg caa atc atc tat ggg ctt ctt tta aat gcc tca      927
 Ser Gln Pro Ile Arg Gln Ile Ile Tyr Gly Leu Leu Leu Asn Ala Ser
         270                 275                 280

 cca cat ctg gac aag aca tcc tgg aat gca ttg cct cct cag cct cta      975
 Pro His Leu Asp Lys Thr Ser Trp Asn Ala Leu Pro Pro Gln Pro Leu
     285                 290                 295

 gct ttc agt gaa gtg gaa agg att aat aaa aat atc aga acc tca atc     1023
 Ala Phe Ser Glu Val Glu Arg Ile Asn Lys Asn Ile Arg Thr Ser Ile
 300                 305                 310                 315

 att gat gca gta gaa ctg gcc aag gat cat tct gac tta agc aga ttg     1071
 Ile Asp Ala Val Glu Leu Ala Lys Asp His Ser Asp Leu Ser Arg Leu
                 320                 325                 330

 act gag ctc tcc ttg agg agg cgg cag atg ctt ctg tta gaa acc ctg     1119
 Thr Glu Leu Ser Leu Arg Arg Arg Gln Met Leu Leu Leu Glu Thr Leu
             335                 340                 345

 aag gtg aaa cag acc att ctg gag cca atc cct act tca ctg aag ttg     1167
 Lys Val Lys Gln Thr Ile Leu Glu Pro Ile Pro Thr Ser Leu Lys Leu
         350                 355                 360

 ccc att gct gtc agt tgc tac tgg ttg cag cac acc gag acc aaa gca     1215
 Pro Ile Ala Val Ser Cys Tyr Trp Leu Gln His Thr Glu Thr Lys Ala
     365                 370                 375

 aag cta cat cat cta caa tcc tta ctg ctc aca atg cta gtg ggg ccc     1263
 Lys Leu His His Leu Gln Ser Leu Leu Leu Thr Met Leu Val Gly Pro
 380                 385                 390                 395

 ttg att gcc ata atc aac agc cct ggt aag gaa gag ctg cag gaa gat     1311
 Leu Ile Ala Ile Ile Asn Ser Pro Gly Lys Glu Glu Leu Gln Glu Asp
                 400                 405                 410

 ggt gct aag atg ttg tat gca gag ttc caa aga gtg aag gcg cag aca     1359
 Gly Ala Lys Met Leu Tyr Ala Glu Phe Gln Arg Val Lys Ala Gln Thr
             415                 420                 425

 cgg ctg ggc aca aga ctg gac tta gac aca gct cac atc ttc tgt cag     1407
 Arg Leu Gly Thr Arg Leu Asp Leu Asp Thr Ala His Ile Phe Cys Gln
         430                 435                 440

 tgg cag tcc tgt ctc cag atg ggg atg tat ctc aac cag ctg ctg tcc     1455
 Trp Gln Ser Cys Leu Gln Met Gly Met Tyr Leu Asn Gln Leu Leu Ser
     445                 450                 455

 act cct ctc cca gag cca gac cta act cga ctg tac agt gga agc ctg     1503
 Thr Pro Leu Pro Glu Pro Asp Leu Thr Arg Leu Tyr Ser Gly Ser Leu
 460                 465                 470                 475

 gtg cac gga cta tgc cag caa ctg cta gca tcg acc tct gta gaa agt     1551
 Val His Gly Leu Cys Gln Gln Leu Leu Ala Ser Thr Ser Val Glu Ser
                 480                 485                 490

 ctc ctg agc ata tgt cct gag gct aag caa ctt tat gaa tat cta ttc     1599
 Leu Leu Ser Ile Cys Pro Glu Ala Lys Gln Leu Tyr Glu Tyr Leu Phe
             495                 500                 505

 aat gcc aca agg tca tat gcc ccc gct gaa ata ttc cta cca aaa ggt     1647
 Asn Ala Thr Arg Ser Tyr Ala Pro Ala Glu Ile Phe Leu Pro Lys Gly
         510                 515                 520

 aga tca aat tca aaa aaa aaa agg cag aag aaa cag aat acc agc tgt     1695
 Arg Ser Asn Ser Lys Lys Lys Arg Gln Lys Lys Gln Asn Thr Ser Cys
     525                 530                 535

 tct aag aac aga ggg aga acc act gca cac acc aag tgt tgg tat gag     1743
 Ser Lys Asn Arg Gly Arg Thr Thr Ala His Thr Lys Cys Trp Tyr Glu
 540                 545                 550                 555

 gga aac aac cgg ttt ggg ttg tta atg gtt gaa aac tta gag gaa cat     1791
 Gly Asn Asn Arg Phe Gly Leu Leu Met Val Glu Asn Leu Glu Glu His
                 560                 565                 570

 agt gag gcc tcc aac att gaa ta aaactcagtt tgcatcaaac tagatgtatt     1844
 Ser Glu Ala Ser Asn Ile Glu 
             575

 taatataatc cttacttaaa attcttccgt taccaccctt gaaacaatta gctttttctt   1904

 taggactgac ctgttagggg ataaacatca caataatctg aattccaagt tattttgtat   1964

 tttgttttta ataaatacaa cctgatttaa gaaaaaaaaa aaaaaaa                 2011




      <210> 46
      <211> 381
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(348)

      <400> 46
 ccgtggccac tacatgcttt gttacataac tagagaagtt tgggctgact tctgctgtgt     60

 gaaaatatcc ctaaagagta cccgaatgag tgtgatctgg tttattaaaa aacactaaga    120

 cactgtggag cctgatttat actaaactta tctaggagag acaaaaaa atg ata gga     177
                                                      Met Ile Gly
                                                        1

 att gtg atc aca gtc atc cct cat ata aac acg gca ttt tta cct aaa      225
 Ile Val Ile Thr Val Ile Pro His Ile Asn Thr Ala Phe Leu Pro Lys
       5                  10                  15

 aaa aaa caa ctt tcc acc aac aca aaa aag cgg tct ccc tct ttt ctc      273
 Lys Lys Gln Leu Ser Thr Asn Thr Lys Lys Arg Ser Pro Ser Phe Leu
  20                  25                  30                  35

 tct ctc ctc tct ctg tgt gtg tgt gtg tgt gtg tgt gtg tgt gtg tgt      321
 Ser Leu Leu Ser Leu Cys Val Cys Val Cys Val Cys Val Cys Val Cys
                  40                  45                  50

 gtg tgt gtg tgt tta ttc ctc tgc ctt taaaa agaccagaag aatgcacaga      373
 Val Cys Val Cys Leu Phe Leu Cys Leu 
              55                  60

 tggattag                                                             381




      <210> 47
      <211> 880
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(388)

      <400> 47
 taacccggca tctgatgccg ttaacgattt gctgaacaca ccagtgtaag gg    atg      55
                                                              Met
                                                                1

 ttt atg acg agc aaa gaa acc ttt acc cat tac cag ccg cag ggc aac      103
 Phe Met Thr Ser Lys Glu Thr Phe Thr His Tyr Gln Pro Gln Gly Asn
               5                  10                  15

 agt gac ccg gct cat acc gca acc gcg ccc ggc gga ttg agt gcg aaa      151
 Ser Asp Pro Ala His Thr Ala Thr Ala Pro Gly Gly Leu Ser Ala Lys
          20                  25                  30

 gcg cct gca atg acc ccg ctg atg ctg gac acc tcc agc cgt aag ctg      199
 Ala Pro Ala Met Thr Pro Leu Met Leu Asp Thr Ser Ser Arg Lys Leu
      35                  40                  45

 gtt gcg tgg gat ggc acc acc gac ggt gct gcc gtt ggc att ctt gcg      247
 Val Ala Trp Asp Gly Thr Thr Asp Gly Ala Ala Val Gly Ile Leu Ala
  50                  55                  60                  65

 gtt gct gct gac cag acc agc acc acg ctg acg ttc tac aag tcc ggc      295
 Val Ala Ala Asp Gln Thr Ser Thr Thr Leu Thr Phe Tyr Lys Ser Gly
                  70                  75                  80

 acg ttc cgt tat gag gat gtg ctc tgg ccg gag gct gcc agc gac aag      343
 Thr Phe Arg Tyr Glu Asp Val Leu Trp Pro Glu Ala Ala Ser Asp Lys
              85                  90                  95

 acg aaa aaa cgg acc gcg ttt gcc gga acg gca atc agc atc gtt taa      391
 Thr Lys Lys Arg Thr Ala Phe Ala Gly Thr Ala Ile Ser Ile Val 
         100                 105                 110

 ctttaccctt catcactaaa ggccgcctgt gcggcttttt ttacgggatt tttttatgtc    451

 gatgtacaca accgcccaac tgctggcggc aaatgagcag aaatttaagt ttgatccgct    511

 gtttctgcgt ctctttttcc gtgagagcta tcccttcacc acggagaaag tctatctctc    571

 acaaattccg ggactggtaa acatggcgct gtacgtttcg ccgattgttt ccggtgaggt    631

 tatccgttcc cgtggcggct ccacctctga atttacgccg ggatatgtca agccgaagca    691

 tgaagtgaat ccgcagatga ccctgcgtcg cctgccggat gaagatccgc agaatctggc    751

 ggacccggct taccgccgcc gtcgcatcat catgcagaac atgcgtgacg aagagctggc    811

 cattgctcag gtcgaagaga tgcaggcagt ttctgccgtg cttaagggca aatacaccat    871

 gaccggtga                                                            880




      <210> 48
      <211> 883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (436)..(711)

      <400> 48
 cattctgtct tttaattttt ttttcttctc tgtttccaca tgctttctcc agtataggat     60

 ttctcagcct tttcactatt gacaattttg gctggataat cctttgttgt ggaggagctc    120

 tcctgggcat tgcagatgtt aggaagaatt cctggcctct ttgcccagat ccaaaatctg    180

 ggcaaagaaa aaatcttctg gaaagaattc agcattctag atgccaataa aaacactgat    240

 gtttcatgga aggagatcaa aatagcaaca ttaacagggg tctggaagaa gttgattctg    300

 acttttgaaa ctgtcagttt caaaatttca ttgtaggaag taactgtgga tgtggtagaa    360

 acagcaagag aacttgaatt agaagtgaac cctgaaaatg tgactagatt gctgctatct    420

 catgatcaaa tttaa atg gat gag gag ttg ctt cat agg gat gaa caa aga     471
                  Met Asp Glu Glu Leu Leu His Arg Asp Glu Gln Arg
                    1               5                  10

 aag tgg ttt ctt gag atg aga tct act cct ggt gaa gat gct gcg aac      519
 Lys Trp Phe Leu Glu Met Arg Ser Thr Pro Gly Glu Asp Ala Ala Asn
          15                  20                  25

 aac gtt gaa atg aca aca aag gac tta aac tat gac aga aac tta gtt      567
 Asn Val Glu Met Thr Thr Lys Asp Leu Asn Tyr Asp Arg Asn Leu Val
      30                  35                  40

 gat aaa gca gtg gta ggg ttt gaa agg act gac tcc aat ttt gaa aga      615
 Asp Lys Ala Val Val Gly Phe Glu Arg Thr Asp Ser Asn Phe Glu Arg
  45                  50                  55                  60

 agt tgt act gtg ggt aaa cag cat tgc atg ata cag aga aat tgt tca      663
 Ser Cys Thr Val Gly Lys Gln His Cys Met Ile Gln Arg Asn Cys Ser
                  65                  70                  75

 tgg aaa gaa gag tac atg gat gca gca aac ttc att gtt gtc tta ttt      711
 Trp Lys Glu Glu Tyr Met Asp Ala Ala Asn Phe Ile Val Val Leu Phe 
              80                  85                  90

 taagaaattg ccacagccac tccatccttc agcaaccacc accctggtct attagaaacc    771

 atcaatatca aggcaagatt ctccaccaac aaaaagctat gactcactga tggctcagat    831

 gatcattagc atttttcagc aataaagtat ttctacatta aaaaaaaaaa aa            883




      <210> 49
      <211> 934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(488)

      <400> 49
 aaccggagta gaag  atg gta gaa atc aat aat caa cgt aag gcg ttc ctc      50
                  Met Val Glu Ile Asn Asn Gln Arg Lys Ala Phe Leu
                    1               5                  10

 gat atg ctg gcg tgg tcg gag gga act gat aac gga cgt cag aaa acc       98
 Asp Met Leu Ala Trp Ser Glu Gly Thr Asp Asn Gly Arg Gln Lys Thr
          15                  20                  25

 aga aat cat ggt tat gac gtc att gta ggc gga gag cta ttc act gat      146
 Arg Asn His Gly Tyr Asp Val Ile Val Gly Gly Glu Leu Phe Thr Asp
      30                  35                  40

 tac tcc gat cac cct cgc aaa ctt gtc acg cta aac cca aaa ctc aaa      194
 Tyr Ser Asp His Pro Arg Lys Leu Val Thr Leu Asn Pro Lys Leu Lys
  45                  50                  55                  60

 tca aca ggc gcc gga cgc tac cag ctt ctt tcc cgt tgg tgg gat gcc      242
 Ser Thr Gly Ala Gly Arg Tyr Gln Leu Leu Ser Arg Trp Trp Asp Ala
                  65                  70                  75

 tac cgc aag cag ctt ggc ctg aaa gac ttc tct ccg aaa agt cag gac      290
 Tyr Arg Lys Gln Leu Gly Leu Lys Asp Phe Ser Pro Lys Ser Gln Asp
              80                  85                  90

 gct gtg gca ttg cag cag att aag gag cgt ggc gct tta cct atg att      338
 Ala Val Ala Leu Gln Gln Ile Lys Glu Arg Gly Ala Leu Pro Met Ile
          95                 100                 105

 gat cgt ggt gat atc cgt cag gca atc gac cgt tgc agc aat atc tgg      386
 Asp Arg Gly Asp Ile Arg Gln Ala Ile Asp Arg Cys Ser Asn Ile Trp
     110                 115                 120

 gct tca ctg ccg ggc gct ggt tat ggt cag ttc gag cat aag gct gac      434
 Ala Ser Leu Pro Gly Ala Gly Tyr Gly Gln Phe Glu His Lys Ala Asp
 125                 130                 135                 140

 agc ctg att gca aaa ttc aaa gaa gcg ggc gga acg gtc aga gag att      482
 Ser Leu Ile Ala Lys Phe Lys Glu Ala Gly Gly Thr Val Arg Glu Ile
                 145                 150                 155

 gat gta tgagcagagt caccgcgatt atctccgctc tggttatctg catcatcgtc       538
 Asp Val 


 tgcctgtcat gggctgttaa tcattaccgt gataacgcca ttacctacaa agcccagcgc    598

 gacaaaaatg ccagagaact gaagctggcg aacgcggcaa ttactgacat gcagatgcgt    658

 cagcgtgatg ttgctgcgct cgatgcaaaa tacacgaagg agttagctga tgctaaagct    718

 gaaaatgatg ctctgcgtga tgatgttgcc gctggtcgtc gtcggttgca catcaaagca    778

 gtctgtcagt cagtgcgtga agccaccacc gcctccggcg tggataatgc agcctccccc    838

 cgactggcag acaccgctga acgggattat ttcaccctca gagagaggct gatcactatg    898

 caaaaacaac tggaaggaac ccagaagtat attaat                              934




      <210> 50
      <211> 1376
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (442)..(1158)

      <400> 50
 gggcctctgt cctgtttgtc cagcccgcca gtttctgcag tggaggtcgc gactgaggga     60

 cgggacagag aagtcgcgaa agtgggcctg aggttctgcg acaccacctc gggtgacgtg    120

 cgccaggccc gggataggga ctgttgtgtt cgaatgcccg ccccggtcgg ccgccgctcc    180

 ccgcctagtc cacggagctc aatggcggca gtcgcgctga gggactcggc tcagtgagag    240

 accgcggagt gttgggtcgt gtagaagtga ctgaacccag aaggtggaga cgagacgttg    300

 tcccgactgc acagaggctg ctctgcagct ccttaaaggc gctaggcgtg acccgcacca    360

 aggccgggat cgggaccacc gggcccgggt acctgcactg ctcgccccct cctttctacc    420

 ccgctttccc cacccagtcg g  atg gcg gcg gcc gcg ctg agg ccc ccg gct     471
                          Met Ala Ala Ala Ala Leu Arg Pro Pro Ala
                            1               5                  10

 cag ggc act gtg acc ttt gaa gat gtg gct gtg aac ttt tcc cag gag      519
 Gln Gly Thr Val Thr Phe Glu Asp Val Ala Val Asn Phe Ser Gln Glu
                  15                  20                  25

 gaa tgg agt ctc ctt agt gag gct cag aga tgc ctt tat cat gac gtg      567
 Glu Trp Ser Leu Leu Ser Glu Ala Gln Arg Cys Leu Tyr His Asp Val
              30                  35                  40

 atg ctg gag aac ctg aca ctt ata tct tct cta ggt tgt tgg tat gga      615
 Met Leu Glu Asn Leu Thr Leu Ile Ser Ser Leu Gly Cys Trp Tyr Gly
          45                  50                  55

 gca aaa gac gag aca cct tct aag cag acc ctt tct ata caa cag gag      663
 Ala Lys Asp Glu Thr Pro Ser Lys Gln Thr Leu Ser Ile Gln Gln Glu
      60                  65                  70

 tcc cca ctc agg aca cat tgg aca ggt gta tgt acc aag aag gtc cac      711
 Ser Pro Leu Arg Thr His Trp Thr Gly Val Cys Thr Lys Lys Val His
  75                  80                  85                  90

 ctc tgg gga atg tgt ggc cct ctc ctg gga gat atc tta cac cag gga      759
 Leu Trp Gly Met Cys Gly Pro Leu Leu Gly Asp Ile Leu His Gln Gly
                  95                 100                 105

 aca caa cac aat cag aaa ttg aat ggg ttt ggg gca tat gaa aaa aaa      807
 Thr Gln His Asn Gln Lys Leu Asn Gly Phe Gly Ala Tyr Glu Lys Lys
             110                 115                 120

 ttg gat gac gat gca aac cat cat caa gac cag aag cag cac att gga      855
 Leu Asp Asp Asp Ala Asn His His Gln Asp Gln Lys Gln His Ile Gly
         125                 130                 135

 gag aaa tcg tac aga agc aat gcc aag gga aca tct ttt gta aag aac      903
 Glu Lys Ser Tyr Arg Ser Asn Ala Lys Gly Thr Ser Phe Val Lys Asn
     140                 145                 150

 tgt aaa ttc cat atg tca cat gag cca ttt atc ttt cat gag gtt ggg      951
 Cys Lys Phe His Met Ser His Glu Pro Phe Ile Phe His Glu Val Gly
 155                 160                 165                 170

 aaa gac ttt ttg tcc agc ttg aga tta ctc caa caa gag gac att cac      999
 Lys Asp Phe Leu Ser Ser Leu Arg Leu Leu Gln Gln Glu Asp Ile His
                 175                 180                 185

 act tca ggg aag tca gac ttt gaa act aag cat ggg ata ccg ctt cag     1047
 Thr Ser Gly Lys Ser Asp Phe Glu Thr Lys His Gly Ile Pro Leu Gln
             190                 195                 200

 ggt gga aaa act cat tac atc tgt gga gag tcc aca tac cgt tta gca     1095
 Gly Gly Lys Thr His Tyr Ile Cys Gly Glu Ser Thr Tyr Arg Leu Ala
         205                 210                 215

 aca aac act ccc ttg ttc ctc cac cag aga ctt cct cct aga gga agg     1143
 Thr Asn Thr Pro Leu Phe Leu His Gln Arg Leu Pro Pro Arg Gly Arg
     220                 225                 230

 acc cta tgt atg cag tgattctggg aaattcactt gcaaaagtaa tagtttttat     1198
 Thr Leu Cys Met Gln 
 235

 tatcctccgg gggttcggcc tgggaaaagg acttactagt gtggcaaagt ggttgaatcc   1258

 ttttggtata gggccacctc actgaacccc gagagttcca ctggaggaag acctctggag   1318

 gtggggatgt gatgaacctc ttgttctaag ccggtcttgt gtgccttgcg ggtctcct     1376




      <210> 51
      <211> 2325
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (277)..(1815)

      <220>
      <221> misc_feature
      <222> (1)...(2325)
      <223> n = a,t,c or g

      <400> 51
 ctcctatgtc tggagagtga tcactttcac tcccaaagac atcctttggt gatacttact     60

 gtgggattca gagtggggtg cagaggacga ccctgcaaag gcacggacta taagagagat    120

 ctgtgcagct gcgcctcagg gggtgtcctg ggcccctggg catgacagga gggggaccac    180

 ttgcagttct actggaaaat ttaccaccct tccagaatcc tctgaagata tacaggtcgc    240

 aactagagtg agacccgagt actgccttgg gtcaga  atg gct aga gaa ccg aga     294
                                          Met Ala Arg Glu Pro Arg
                                            1               5

 aaa aac gca gcc ctg gac gcc cag tct gca gaa gac cag acg ggg ttc      342
 Lys Asn Ala Ala Leu Asp Ala Gln Ser Ala Glu Asp Gln Thr Gly Phe
              10                  15                  20

 ctg acc gtg aag gtg gag aag gag gaa gcc ttc gcc ttg acg gcg gag      390
 Leu Thr Val Lys Val Glu Lys Glu Glu Ala Phe Ala Leu Thr Ala Glu
          25                  30                  35

 gtg aga gca ccc tgc agc cct gct cgg ggc ccc gaa cgc tcc cgc cag      438
 Val Arg Ala Pro Cys Ser Pro Ala Arg Gly Pro Glu Arg Ser Arg Gln
      40                  45                  50

 cgc ttc cga ggc ttc cgc tac ccg gag gct gcg ggc ccc cgc gag gcg      486
 Arg Phe Arg Gly Phe Arg Tyr Pro Glu Ala Ala Gly Pro Arg Glu Ala
  55                  60                  65                  70

 ttg agc cgg ctc cga gaa ctc tgc gga caa tgg ctg cag cct gag atg      534
 Leu Ser Arg Leu Arg Glu Leu Cys Gly Gln Trp Leu Gln Pro Glu Met
                  75                  80                  85

 cac agc aag gag cag atc ctg gag ctg ctg gtg ctg gag cag ttc ctg      582
 His Ser Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu
              90                  95                 100

 acc atc ctg ccg ggg aat ctg cag agc tgg gtg cgg gag cag cat cca      630
 Thr Ile Leu Pro Gly Asn Leu Gln Ser Trp Val Arg Glu Gln His Pro
         105                 110                 115

 gag agc ggg gag gag gtg gtg gtg cta ttg gag tat ttg gag agg cag      678
 Glu Ser Gly Glu Glu Val Val Val Leu Leu Glu Tyr Leu Glu Arg Gln
     120                 125                 130

 ctg gat gag ccg gcg ccg cag gta gaa aga aca ggt tta gta tct gag      726
 Leu Asp Glu Pro Ala Pro Gln Val Glu Arg Thr Gly Leu Val Ser Glu
 135                 140                 145                 150

 cgc tgt ggt ctg ttt cct cct gaa atc cca gat cgg agc gag ggg cat      774
 Arg Cys Gly Leu Phe Pro Pro Glu Ile Pro Asp Arg Ser Glu Gly His
                 155                 160                 165

 tcc ttt aag gtc cag gag ttc ttc atc tct ttt tgt act gtg aac ctc      822
 Ser Phe Lys Val Gln Glu Phe Phe Ile Ser Phe Cys Thr Val Asn Leu
             170                 175                 180

 ctt ggc agt aag ggt ttg ctg aaa atg gaa gat gtg gcc ctg acc ctc      870
 Leu Gly Ser Lys Gly Leu Leu Lys Met Glu Asp Val Ala Leu Thr Leu
         185                 190                 195

 act cct ggg tgg aca cag ctg gat tca tct cag gtg aac ctc tac aga      918
 Thr Pro Gly Trp Thr Gln Leu Asp Ser Ser Gln Val Asn Leu Tyr Arg
     200                 205                 210

 gat gaa aag cag gag aac cat agc agc ctg gtc tcc ctt ggt ggt gaa      966
 Asp Glu Lys Gln Glu Asn His Ser Ser Leu Val Ser Leu Gly Gly Glu
 215                 220                 225                 230

 ata cag act aag agc agg gac ttg cct cca gtc aag aag ctt cca gaa     1014
 Ile Gln Thr Lys Ser Arg Asp Leu Pro Pro Val Lys Lys Leu Pro Glu
                 235                 240                 245

 aag gag cat ggg aag ata tgc cac ctg agg gaa gac att gcc cag att     1062
 Lys Glu His Gly Lys Ile Cys His Leu Arg Glu Asp Ile Ala Gln Ile
             250                 255                 260

 cct aca cat gca gaa gct ggt gaa cag gag ggc agg tta caa aga aag     1110
 Pro Thr His Ala Glu Ala Gly Glu Gln Glu Gly Arg Leu Gln Arg Lys
         265                 270                 275

 cag aaa aat gcc ata ggg agt agg cga cat tat tgc cat gaa tgt gga     1158
 Gln Lys Asn Ala Ile Gly Ser Arg Arg His Tyr Cys His Glu Cys Gly
     280                 285                 290

 aag agt ttt gct caa agt tca ggc ctg act aaa cac agg aga atc cac     1206
 Lys Ser Phe Ala Gln Ser Ser Gly Leu Thr Lys His Arg Arg Ile His
 295                 300                 305                 310

 act ggt gag aaa ccc tat gaa tgt gaa gac tgt gga aag acc ttc att     1254
 Thr Gly Glu Lys Pro Tyr Glu Cys Glu Asp Cys Gly Lys Thr Phe Ile
                 315                 320                 325

 ggg agc tct gcc ctt gtc att cat cag aga gtc cac act ggt gag aag     1302
 Gly Ser Ser Ala Leu Val Ile His Gln Arg Val His Thr Gly Glu Lys
             330                 335                 340

 cca tat gag tgt gaa gaa tgt ggt aag gtc ttc agt cac agc tca aac     1350
 Pro Tyr Glu Cys Glu Glu Cys Gly Lys Val Phe Ser His Ser Ser Asn
         345                 350                 355

 ctt atc aaa cac cag aga acc cac act ggg gag aag ccc tat gag tgt     1398
 Leu Ile Lys His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys
     360                 365                 370

 gat gac tgt ggg aag acc ttc agc cag agc tgc agc ctc ctt gaa cat     1446
 Asp Asp Cys Gly Lys Thr Phe Ser Gln Ser Cys Ser Leu Leu Glu His
 375                 380                 385                 390

 cac aaa att cat act ggg gag aag cca tac cag tgc aat atg tgt ggc     1494
 His Lys Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Asn Met Cys Gly
                 395                 400                 405

 aaa gcc ttt agg cgg aat tca cat ctc ctg aga cat cag agg att cat     1542
 Lys Ala Phe Arg Arg Asn Ser His Leu Leu Arg His Gln Arg Ile His
             410                 415                 420

 ggt gat aaa aat gtt cag aat cct gag cac ggg gag tcc tgg gaa agt     1590
 Gly Asp Lys Asn Val Gln Asn Pro Glu His Gly Glu Ser Trp Glu Ser
         425                 430                 435

 cag ggt agg acg gaa agc cag tgg gaa aat act gag gct ccc gtg tct     1638
 Gln Gly Arg Thr Glu Ser Gln Trp Glu Asn Thr Glu Ala Pro Val Ser
     440                 445                 450

 tat aaa tgt aat gag tgt gag aga agt ttc aca cgg aat aga agt ctt     1686
 Tyr Lys Cys Asn Glu Cys Glu Arg Ser Phe Thr Arg Asn Arg Ser Leu
 455                 460                 465                 470

 att gaa cat cag aaa atc cac act ggt gag aaa ccc tat cag tgt gac     1734
 Ile Glu His Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Asp
                 475                 480                 485

 aca tgt gga aaa ggt ttc act cga act tca tac ctt gtt caa cat cag     1782
 Thr Cys Gly Lys Gly Phe Thr Arg Thr Ser Tyr Leu Val Gln His Gln
             490                 495                 500

 aga agc cat gta ggg aaa aaa act ctt tca cag tgacccat ggtattcatg     1833
 Arg Ser His Val Gly Lys Lys Thr Leu Ser Gln 
         505                 510

 ccaacattgg tgctcatttg tcactgaact gaagccaccc tggagccctt aatggttaca   1893

 gaaattgtgg accagggctt tatttaccac tatacatcat caggtattag acaatgtagt   1953

 ctggctaaga tgatgagtta ttttcaacat ttctaaaagg gatttgaaaa aagtcatttg   2013

 ataagaggcc atgggagagt ggtctggaag ttgtaggacc taaaatagtt tgttctcacc   2073

 cagtgtattt aaatggcctt ctggacttgt taattgccct cagccagcac tttaggacat   2133

 ctggttggat ggctctgatg tggggggctg ctgctctgac cattcatttt gcctctaatg   2193

 aatctttcac aaattggtca gatccatgag gtcttttact cttctttgtg ccttgtatga   2253

 taggtgctna ataaacattt attaaatgta ccagtaaaat ggcctttgta ccaaaaattt   2313

 aaaaaaaaaa aa                                                       2325




      <210> 52
      <211> 921
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(762)

      <400> 52
 cagcggttca gctgaggtag ggacgtgctg taggccgga   atg tta ccg gct gtt      54
                                              Met Leu Pro Ala Val
                                                1               5

 gga tct gcg gat gag gag gag gat cct gcg gag gag gat tgt cct gaa      102
 Gly Ser Ala Asp Glu Glu Glu Asp Pro Ala Glu Glu Asp Cys Pro Glu
                  10                  15                  20

 ttg gtt ccc atg gag acg acg caa agc gag gag gag gaa aag tct ggc      150
 Leu Val Pro Met Glu Thr Thr Gln Ser Glu Glu Glu Glu Lys Ser Gly
              25                  30                  35

 ctc ggc gcc aag atc cca gtc aca att atc acc ggg tat tta ggt gct      198
 Leu Gly Ala Lys Ile Pro Val Thr Ile Ile Thr Gly Tyr Leu Gly Ala
          40                  45                  50

 ggg aag aca aca ctt ctg aac tat att ttg aca gag caa cat agt aaa      246
 Gly Lys Thr Thr Leu Leu Asn Tyr Ile Leu Thr Glu Gln His Ser Lys
      55                  60                  65

 aga gta gcg gtc att tta aat gaa ttt ggg gaa gga agt gcg ctg gag      294
 Arg Val Ala Val Ile Leu Asn Glu Phe Gly Glu Gly Ser Ala Leu Glu
  70                  75                  80                  85

 aaa tcc tta gct gtc agc caa ggt gga gag ctc tat gaa gag tgg ctg      342
 Lys Ser Leu Ala Val Ser Gln Gly Gly Glu Leu Tyr Glu Glu Trp Leu
                  90                  95                 100

 gaa ctt aga aac ggt tgc ctc tgc tgt tca gtg aag gac aat ggc ctt      390
 Glu Leu Arg Asn Gly Cys Leu Cys Cys Ser Val Lys Asp Asn Gly Leu
             105                 110                 115

 aga gct att gag aat ttg atg caa aag aag ggg aaa ttt gat tac ata      438
 Arg Ala Ile Glu Asn Leu Met Gln Lys Lys Gly Lys Phe Asp Tyr Ile
         120                 125                 130

 ctg tta gag acc act gga ttg gca gac cca ggt gca gtg gct tct atg      486
 Leu Leu Glu Thr Thr Gly Leu Ala Asp Pro Gly Ala Val Ala Ser Met
     135                 140                 145

 ttt tgg gtt gat gct gaa tta ggg agt gat att tac ctt gat ggt atc      534
 Phe Trp Val Asp Ala Glu Leu Gly Ser Asp Ile Tyr Leu Asp Gly Ile
 150                 155                 160                 165

 ata act ata gtg gat tca aaa tat gga tta aaa cat tta gca gaa gag      582
 Ile Thr Ile Val Asp Ser Lys Tyr Gly Leu Lys His Leu Ala Glu Glu
                 170                 175                 180

 aaa cct gat ggc ctt atc aat gaa gct act agg caa gtt gct ttg gca      630
 Lys Pro Asp Gly Leu Ile Asn Glu Ala Thr Arg Gln Val Ala Leu Ala
             185                 190                 195

 gat gcc att ctc att aat aaa aca gac ttg gtt cca gaa gaa gat gta      678
 Asp Ala Ile Leu Ile Asn Lys Thr Asp Leu Val Pro Glu Glu Asp Val
         200                 205                 210

 aag aaa tta aga gcg aca att aga tcc ata aat gga cta gga caa atc      726
 Lys Lys Leu Arg Ala Thr Ile Arg Ser Ile Asn Gly Leu Gly Gln Ile
     215                 220                 225

 tta gaa aca caa aga tca aga aca ata aac atg cag tgat tgatttttct      776
 Leu Glu Thr Gln Arg Ser Arg Thr Ile Asn Met Gln 
 230                 235                 240

 tacttcaagt ggatgagtga gcaagtgact aaaatcttcc gtgaattctt cagtagttga    836

 tctctctaat gtattagatc ttcatgcctt tgatagtctc tctggaataa gtttgcagaa    896

 aaaacttcag catgtgccag gaatt                                          921




      <210> 53
      <211> 3173
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (375)..(2657)

      <220>
      <221> misc_feature
      <222> (1)...(3173)
      <223> n = a,t,c or g

      <400> 53
 cgcggcaagg ggcagagaag gagccaagtg gcgacgtggt catgcgcaga aagatccgtc     60

 cggctctctg agcagagggt agcgtgtggg ggcgggatac cgacgcggct cggctgccga    120

 ttggtcagaa gaggatagaa aggggcggga agccggcgcg gctcgactcc cgattggcca    180

 gaggcggcag aacggggtgg ggccaaacga cgcgcgttct gtggcgcgcg gcctggcggg    240

 cgtgcaacgg ccgttagagg agctgaggga gggaaccacc gctcaccgca gacgtggtgg    300

 ctgcagtcag tcttcccgag tgagggattt cgccgcccgc tttcaggccc gtttggctta    360

 aataactgtg attg  atg gcc atg cag gag aaa tat cca act gag ggg atc     410
                  Met Ala Met Gln Glu Lys Tyr Pro Thr Glu Gly Ile
                    1               5                  10

 tct cac gtc act tca ccg agt tcc gat gtg att cag aag ggc agt tcc      458
 Ser His Val Thr Ser Pro Ser Ser Asp Val Ile Gln Lys Gly Ser Ser
          15                  20                  25

 ctg ggg act gaa tgg cag acc cca gtt atc tcg gag ccc ttt cgg agc      506
 Leu Gly Thr Glu Trp Gln Thr Pro Val Ile Ser Glu Pro Phe Arg Ser
      30                  35                  40

 cgc ttc agc cgc tgt tca agt gta gcc gac agt ggg gac aca gcc att      554
 Arg Phe Ser Arg Cys Ser Ser Val Ala Asp Ser Gly Asp Thr Ala Ile
  45                  50                  55                  60

 ggt aca tca tgc tca gat att gcg gag gat ttt tgc agc tca agt ggc      602
 Gly Thr Ser Cys Ser Asp Ile Ala Glu Asp Phe Cys Ser Ser Ser Gly
                  65                  70                  75

 agt cct cct ttc cag ccc atc aaa agc cac gta acc att cca aca gcc      650
 Ser Pro Pro Phe Gln Pro Ile Lys Ser His Val Thr Ile Pro Thr Ala
              80                  85                  90

 cat gtg atg cct tct act tta ggg acc tct cct gcc aag cca aat tct      698
 His Val Met Pro Ser Thr Leu Gly Thr Ser Pro Ala Lys Pro Asn Ser
          95                 100                 105

 aca cct gtt gga ccc tct tcc tct aaa ctc cct ttg tca ggg ttg gct      746
 Thr Pro Val Gly Pro Ser Ser Ser Lys Leu Pro Leu Ser Gly Leu Ala
     110                 115                 120

 gaa agt gtg gga atg aca aga aat gga gac ctc ggt gca atg aaa cat      794
 Glu Ser Val Gly Met Thr Arg Asn Gly Asp Leu Gly Ala Met Lys His
 125                 130                 135                 140

 tct cca ggc cta tct aga gat ctc atg tat ttc tct ggt gct act gga      842
 Ser Pro Gly Leu Ser Arg Asp Leu Met Tyr Phe Ser Gly Ala Thr Gly
                 145                 150                 155

 gaa aat gga att gag cag tcc tgg ttt cca gca gtg ggc cat gaa aga      890
 Glu Asn Gly Ile Glu Gln Ser Trp Phe Pro Ala Val Gly His Glu Arg
             160                 165                 170

 caa gaa gag gcg agg aag ttt gat att cct agc atg gaa tct acc ctc      938
 Gln Glu Glu Ala Arg Lys Phe Asp Ile Pro Ser Met Glu Ser Thr Leu
         175                 180                 185

 aat cag tcg gca atg atg gag aca ctt tat tca gat cct cac cac cga      986
 Asn Gln Ser Ala Met Met Glu Thr Leu Tyr Ser Asp Pro His His Arg
     190                 195                 200

 gtc cgc ttc cac aac cca aga acc agc aca agt aag gag ttg tac aga     1034
 Val Arg Phe His Asn Pro Arg Thr Ser Thr Ser Lys Glu Leu Tyr Arg
 205                 210                 215                 220

 gtg ttg cct gag gcc aag aag gca ccg ggc agc ggg gca gtg ttt gag     1082
 Val Leu Pro Glu Ala Lys Lys Ala Pro Gly Ser Gly Ala Val Phe Glu
                 225                 230                 235

 cgg aat gga cca cat tct aat agc agt ggg gtc ctc cct ttg gga ctc     1130
 Arg Asn Gly Pro His Ser Asn Ser Ser Gly Val Leu Pro Leu Gly Leu
             240                 245                 250

 cag cct gct ccc ggg ctc tcc aag cct ctg ccc tct cag gtg tgg cag     1178
 Gln Pro Ala Pro Gly Leu Ser Lys Pro Leu Pro Ser Gln Val Trp Gln
         255                 260                 265

 ccg agt cct gac act tgg cat ccc cga gag caa tct tgt gaa ctc agc     1226
 Pro Ser Pro Asp Thr Trp His Pro Arg Glu Gln Ser Cys Glu Leu Ser
     270                 275                 280

 act tgt cgg cag cag ctg gaa ttg att cgt tta cag atg gag caa atg     1274
 Thr Cys Arg Gln Gln Leu Glu Leu Ile Arg Leu Gln Met Glu Gln Met
 285                 290                 295                 300

 cag ctt cag aat gga gcc atc tgc cac cat cct gct gct ttt ggt cct     1322
 Gln Leu Gln Asn Gly Ala Ile Cys His His Pro Ala Ala Phe Gly Pro
                 305                 310                 315

 tca ctg ccc atc tta gag cca gca cag tgg atc agc atc ttg aac agt     1370
 Ser Leu Pro Ile Leu Glu Pro Ala Gln Trp Ile Ser Ile Leu Asn Ser
             320                 325                 330

 aat gaa cac ctt ctg aag gaa aaa gag ctt ctc att gac aag cag agg     1418
 Asn Glu His Leu Leu Lys Glu Lys Glu Leu Leu Ile Asp Lys Gln Arg
         335                 340                 345

 aaa cac atc tct cag ctg gag cag aaa gtg cga gag agc gaa ctg caa     1466
 Lys His Ile Ser Gln Leu Glu Gln Lys Val Arg Glu Ser Glu Leu Gln
     350                 355                 360

 gtc cac agt gcc ctc ttg ggc cgc cct gcc ccc ttt ggt gat gtc tgc     1514
 Val His Ser Ala Leu Leu Gly Arg Pro Ala Pro Phe Gly Asp Val Cys
 365                 370                 375                 380

 ttg ctg agg cta cag gaa ttg cag cga gaa aac act ttc tta cgt gca     1562
 Leu Leu Arg Leu Gln Glu Leu Gln Arg Glu Asn Thr Phe Leu Arg Ala
                 385                 390                 395

 cag ttt gca cag aag aca gaa gcc ttg agc aga gaa aag att gac ctt     1610
 Gln Phe Ala Gln Lys Thr Glu Ala Leu Ser Arg Glu Lys Ile Asp Leu
             400                 405                 410

 gaa aag aaa ctc tct gct tct gaa gtt gaa gtc cag ctc atc aga gag     1658
 Glu Lys Lys Leu Ser Ala Ser Glu Val Glu Val Gln Leu Ile Arg Glu
         415                 420                 425

 tcg ctc aaa gtg gcg ttg cag aag cat tct gag gaa gtg aag aaa cag     1706
 Ser Leu Lys Val Ala Leu Gln Lys His Ser Glu Glu Val Lys Lys Gln
     430                 435                 440

 gaa gaa agg gtc aaa ggt cgt gat aaa cat atc aat aat ttg aaa aag     1754
 Glu Glu Arg Val Lys Gly Arg Asp Lys His Ile Asn Asn Leu Lys Lys
 445                 450                 455                 460

 aaa tgc cag aag gaa tca gag cag aac cgg gag aag cag cag cgt att     1802
 Lys Cys Gln Lys Glu Ser Glu Gln Asn Arg Glu Lys Gln Gln Arg Ile
                 465                 470                 475

 gag acc ttg gag cgc tac ctg gct gac ctg ccc aca ctg gaa gac cat     1850
 Glu Thr Leu Glu Arg Tyr Leu Ala Asp Leu Pro Thr Leu Glu Asp His
             480                 485                 490

 cag aag cag agc cag cag ctt aag gat tct gag ttg aag agc aca gag     1898
 Gln Lys Gln Ser Gln Gln Leu Lys Asp Ser Glu Leu Lys Ser Thr Glu
         495                 500                 505

 ctg cag gag aaa gtg act gag ctg gag agt ttg ctg gag gag acc cag     1946
 Leu Gln Glu Lys Val Thr Glu Leu Glu Ser Leu Leu Glu Glu Thr Gln
     510                 515                 520

 gca atc tgc aga gag aag gag att caa ctg gaa agc ctg agg cag aga     1994
 Ala Ile Cys Arg Glu Lys Glu Ile Gln Leu Glu Ser Leu Arg Gln Arg
 525                 530                 535                 540

 gaa gca gaa ttc tcc tcc gct gga cat agc ctg caa gat aaa cag tct     2042
 Glu Ala Glu Phe Ser Ser Ala Gly His Ser Leu Gln Asp Lys Gln Ser
                 545                 550                 555

 gtg gag gag acc agt gga gaa ggt cca gaa gtg gaa atg gag tcc tgg     2090
 Val Glu Glu Thr Ser Gly Glu Gly Pro Glu Val Glu Met Glu Ser Trp
             560                 565                 570

 cag aag cga tac gat tcg ctc caa aag att gtg gag aag cag cag cag     2138
 Gln Lys Arg Tyr Asp Ser Leu Gln Lys Ile Val Glu Lys Gln Gln Gln
         575                 580                 585

 aag atg gat cag ttg cgc tca caa gta cag agc cta gag cag gaa gtg     2186
 Lys Met Asp Gln Leu Arg Ser Gln Val Gln Ser Leu Glu Gln Glu Val
     590                 595                 600

 gct caa gaa gaa gga aca agc cag gcc ctg aga gag gag gcc cag cga     2234
 Ala Gln Glu Glu Gly Thr Ser Gln Ala Leu Arg Glu Glu Ala Gln Arg
 605                 610                 615                 620

 agg gat tca gcc ctg cag cag ctg cgc aca gcc gtg aag gag ctt tca     2282
 Arg Asp Ser Ala Leu Gln Gln Leu Arg Thr Ala Val Lys Glu Leu Ser
                 625                 630                 635

 gtg caa aac cag gac ttg att gag aag aat ctg aca ctc cag gaa cac     2330
 Val Gln Asn Gln Asp Leu Ile Glu Lys Asn Leu Thr Leu Gln Glu His
             640                 645                 650

 ctg cgc cag gcc caa cca ggg tct cca cct tca cca gac acg gcc cag     2378
 Leu Arg Gln Ala Gln Pro Gly Ser Pro Pro Ser Pro Asp Thr Ala Gln
         655                 660                 665

 ctg gca ctt gag ctg cac cag gag ttg gcc agt tgc ctt caa gat ctg     2426
 Leu Ala Leu Glu Leu His Gln Glu Leu Ala Ser Cys Leu Gln Asp Leu
     670                 675                 680

 cag gct gtc tgt agc att gtg acc cag agg gcc cag ggc cat gac ccc     2474
 Gln Ala Val Cys Ser Ile Val Thr Gln Arg Ala Gln Gly His Asp Pro
 685                 690                 695                 700

 aat ctc tcc ctg ctc ctg ggc att cac tca cag cac cca gag act cag     2522
 Asn Leu Ser Leu Leu Leu Gly Ile His Ser Gln His Pro Glu Thr Gln
                 705                 710                 715

 cta gat ttg cag aag cca gat gtg atc aag agg aaa cta gaa gag gtt     2570
 Leu Asp Leu Gln Lys Pro Asp Val Ile Lys Arg Lys Leu Glu Glu Val
             720                 725                 730

 caa cag ctg cgt cgt gac att gag gac tta agg acc acc atg tca gac     2618
 Gln Gln Leu Arg Arg Asp Ile Glu Asp Leu Arg Thr Thr Met Ser Asp
         735                 740                 745

 aga tat gcc cag gac atg gga gaa aac tgt gtc aca cag tgaggaattc      2667
 Arg Tyr Ala Gln Asp Met Gly Glu Asn Cys Val Thr Gln 
     750                 755                 760

 tgggggattc ccccagggag gagctgggct gctgagagcc tagtccagca ggtttctgcc   2727

 ctgacattct cttgtctgct attcccagag aggtctcaaa ggggagggga gagcctgcat   2787

 ctgggggcca agggctgatt agggaactgt gtcctaccca cactggcatg ttggattacg   2847

 tttgtcctgt taattcactc tcgacggtga gttactaatt aacttttggc aggtacaaca   2907

 gataagtcct cacanactgt tcccagccct tagctgacag gaaagacgaa caggctgttc   2967

 acctttcttc tccatccaat gggatggatc catgtttatt tccccttcac accttggtcc   3027

 ttgtggatag aaaagctatt aaaagggccc gggaaagggt tgacaagtac cagtggacat   3087

 gggcatttta agaattttca aggccccatg tgccaaccct cctggggaac tggagcgggc   3147

 tttctggggt tttctaaagc ctgggg                                        3173




      <210> 54
      <211> 6288
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (303)..(4934)

      <400> 54
 taagcttgcg tccgccgctc cgcctcccag gatgagctga atcagcttga acgggtcttt     60

 ttacgacttg gccatgctga aacagatgaa caattacaga atattatatc taaattcctt    120

 cctcctgttt tgctcaaact ctctagcacc caagaaggag tacgtaaaaa ggtaatggaa    180

 ctgctggtcc atctgaataa acgtataaaa aaccgcccca aaatacaact tccagtagag    240

 acctggaatt gaaaagcaaa cagagcttaa ttgactggaa taatcctgcc atcattaata    300

 ag   atg tac aag gtg tac ctt gga gat ata cca ctg aag aca aaa gag     347
      Met Tyr Lys Val Tyr Leu Gly Asp Ile Pro Leu Lys Thr Lys Glu
        1               5                  10                  15

 ggt gca gtt ctg aag cca gag ttg aaa agg gac cct gtc agt aca aga      395
 Gly Ala Val Leu Lys Pro Glu Leu Lys Arg Asp Pro Val Ser Thr Arg
                  20                  25                  30

 gtc aag tta aag att gtc ccc cat ctc ctc cgc tct aga caa gct gct      443
 Val Lys Leu Lys Ile Val Pro His Leu Leu Arg Ser Arg Gln Ala Ala
              35                  40                  45

 gaa acg ttc cca gcc aac att cag gtg gtg tat gat gga ctt ttt ggt      491
 Glu Thr Phe Pro Ala Asn Ile Gln Val Val Tyr Asp Gly Leu Phe Gly
          50                  55                  60

 aca aat aca aat tca aag tta aga aca tta tcc ctg caa ttt gtg cat      539
 Thr Asn Thr Asn Ser Lys Leu Arg Thr Leu Ser Leu Gln Phe Val His
      65                  70                  75

 cat att tgt ata acc tgt cca gaa atc aag att aag cca tta ggt cca      587
 His Ile Cys Ile Thr Cys Pro Glu Ile Lys Ile Lys Pro Leu Gly Pro
  80                  85                  90                  95

 atg ctt ttg aat ggc ctc acc aag cta atc aat gaa tac aaa gag gac      635
 Met Leu Leu Asn Gly Leu Thr Lys Leu Ile Asn Glu Tyr Lys Glu Asp
                 100                 105                 110

 cct aaa cta ctg tca atg gca tat tca gct gtt gga aaa ctc tcc agt      683
 Pro Lys Leu Leu Ser Met Ala Tyr Ser Ala Val Gly Lys Leu Ser Ser
             115                 120                 125

 cgg atg cca cat tta ttc act aag gat ata gcg ctt gtg cag cag ctt      731
 Arg Met Pro His Leu Phe Thr Lys Asp Ile Ala Leu Val Gln Gln Leu
         130                 135                 140

 ttt gaa gcc ctt tgc aag gaa gag cct gag act cga ctt gct att caa      779
 Phe Glu Ala Leu Cys Lys Glu Glu Pro Glu Thr Arg Leu Ala Ile Gln
     145                 150                 155

 gaa gct tta tct atg atg gtt gga gcg tat agt act ttg gaa ggg gca      827
 Glu Ala Leu Ser Met Met Val Gly Ala Tyr Ser Thr Leu Glu Gly Ala
 160                 165                 170                 175

 cag cga act ctc atg gag gca ctt gtg gct tcg tac tta ata aag cct      875
 Gln Arg Thr Leu Met Glu Ala Leu Val Ala Ser Tyr Leu Ile Lys Pro
                 180                 185                 190

 gaa gtt caa gtt cga caa gtg gct gtg aaa ttt gcc agt acg gtg ttt      923
 Glu Val Gln Val Arg Gln Val Ala Val Lys Phe Ala Ser Thr Val Phe
             195                 200                 205

 ccc tca gat cat atc cct tcc aga tat ttg ctg cta ctg gct gca gga      971
 Pro Ser Asp His Ile Pro Ser Arg Tyr Leu Leu Leu Leu Ala Ala Gly
         210                 215                 220

 gat cca cgt gaa gaa gtt cat gga gaa gca caa cgc gta tta agg tgt     1019
 Asp Pro Arg Glu Glu Val His Gly Glu Ala Gln Arg Val Leu Arg Cys
     225                 230                 235

 ctt cca ggt aga aac aga aaa gaa agt act tct gag cag atg cct tcc     1067
 Leu Pro Gly Arg Asn Arg Lys Glu Ser Thr Ser Glu Gln Met Pro Ser
 240                 245                 250                 255

 ttc cca gaa atg gtt tat tac atc caa gaa aag gct tct cat cga atg     1115
 Phe Pro Glu Met Val Tyr Tyr Ile Gln Glu Lys Ala Ser His Arg Met
                 260                 265                 270

 aaa act cca gtc aag tac atg acc ggg acc act gtc ctt cca ttt aac     1163
 Lys Thr Pro Val Lys Tyr Met Thr Gly Thr Thr Val Leu Pro Phe Asn
             275                 280                 285

 cca gca gcc ttt gga gag atc gtt ctg tac ttg cgc atg tgc ctt gcg     1211
 Pro Ala Ala Phe Gly Glu Ile Val Leu Tyr Leu Arg Met Cys Leu Ala
         290                 295                 300

 cac agt gcg ggg gtg gtg ccc acc tct cag agt ttg gct gat atg cag     1259
 His Ser Ala Gly Val Val Pro Thr Ser Gln Ser Leu Ala Asp Met Gln
     305                 310                 315

 gat cat gcc cca gcc att ggg cgc tac ata cgg act tta atg tca agc     1307
 Asp His Ala Pro Ala Ile Gly Arg Tyr Ile Arg Thr Leu Met Ser Ser
 320                 325                 330                 335

 ggg cag atg gca ccc tca tca tct aac aag agt ggg gag act aac cct     1355
 Gly Gln Met Ala Pro Ser Ser Ser Asn Lys Ser Gly Glu Thr Asn Pro
                 340                 345                 350

 gtc cag atc tac att ggc ctg ctt cag cag ctg tta gca ggt gtt gga     1403
 Val Gln Ile Tyr Ile Gly Leu Leu Gln Gln Leu Leu Ala Gly Val Gly
             355                 360                 365

 ggt ttg ccg gtt atg tac tgt cta ttg gaa gct gtg tca gtg tat cca     1451
 Gly Leu Pro Val Met Tyr Cys Leu Leu Glu Ala Val Ser Val Tyr Pro
         370                 375                 380

 gaa aag ctg gct acc aaa ttt gta gac aaa aca gaa tgg ata aag agt     1499
 Glu Lys Leu Ala Thr Lys Phe Val Asp Lys Thr Glu Trp Ile Lys Ser
     385                 390                 395

 ctg atg aat aac agt aaa gaa gaa atg cgc gaa ctg gca gcg ttg ttt     1547
 Leu Met Asn Asn Ser Lys Glu Glu Met Arg Glu Leu Ala Ala Leu Phe
 400                 405                 410                 415

 tat tct gta gtg gta tca aca gtg tcg ggg aat gag ttg aaa tca atg     1595
 Tyr Ser Val Val Val Ser Thr Val Ser Gly Asn Glu Leu Lys Ser Met
                 420                 425                 430

 ata gaa cag ctt ata aag act aca aaa gac aat cac agc ccg gag ata     1643
 Ile Glu Gln Leu Ile Lys Thr Thr Lys Asp Asn His Ser Pro Glu Ile
             435                 440                 445

 cag cat gga tcc ttg ctt gca ttg gga ttc acg gtg gga agg tat ttg     1691
 Gln His Gly Ser Leu Leu Ala Leu Gly Phe Thr Val Gly Arg Tyr Leu
         450                 455                 460

 gct aaa aag aaa atg aga atg tca gag caa caa gac ctg gag aga aat     1739
 Ala Lys Lys Lys Met Arg Met Ser Glu Gln Gln Asp Leu Glu Arg Asn
     465                 470                 475

 gct gac acc ctc cct gat caa gag gaa ctc att cag agt gct aca gaa     1787
 Ala Asp Thr Leu Pro Asp Gln Glu Glu Leu Ile Gln Ser Ala Thr Glu
 480                 485                 490                 495

 aca ata ggc tca ttt ttg gac agt aca tca ccc ctc ctg gca att gct     1835
 Thr Ile Gly Ser Phe Leu Asp Ser Thr Ser Pro Leu Leu Ala Ile Ala
                 500                 505                 510

 gcc tgc aca gcc ctg ggt gaa att ggc aga aat ggt cca ctt cca atc     1883
 Ala Cys Thr Ala Leu Gly Glu Ile Gly Arg Asn Gly Pro Leu Pro Ile
             515                 520                 525

 ccc agt gag gga tct ggc ttt acc aaa ttg cat ctt gta gaa agc tta     1931
 Pro Ser Glu Gly Ser Gly Phe Thr Lys Leu His Leu Val Glu Ser Leu
         530                 535                 540

 cta agt aga ata cct tcc agt aaa gaa aca aat aag atg aaa gaa cga     1979
 Leu Ser Arg Ile Pro Ser Ser Lys Glu Thr Asn Lys Met Lys Glu Arg
     545                 550                 555

 gca atc caa aca ctg gga tat ttt cca gtt ggg gat gga gat ttt cct     2027
 Ala Ile Gln Thr Leu Gly Tyr Phe Pro Val Gly Asp Gly Asp Phe Pro
 560                 565                 570                 575

 cac cag aaa ctc ctc ttg caa ggt ctg atg gat tct gtg gag gcc aag     2075
 His Gln Lys Leu Leu Leu Gln Gly Leu Met Asp Ser Val Glu Ala Lys
                 580                 585                 590

 cag ata gaa ctt cag ttc act att ggc gaa gcc att acc agt gct gca     2123
 Gln Ile Glu Leu Gln Phe Thr Ile Gly Glu Ala Ile Thr Ser Ala Ala
             595                 600                 605

 ata gga act agt tct gtg gct gcc cga gat gcc tgg caa atg act gaa     2171
 Ile Gly Thr Ser Ser Val Ala Ala Arg Asp Ala Trp Gln Met Thr Glu
         610                 615                 620

 gag gaa tat act cca cct gct gga gcc aaa gtg aat gat gtg gtt cca     2219
 Glu Glu Tyr Thr Pro Pro Ala Gly Ala Lys Val Asn Asp Val Val Pro
     625                 630                 635

 tgg gtg ttg gat gtg att tta aat aaa cat atc atc agc ccc aac cca     2267
 Trp Val Leu Asp Val Ile Leu Asn Lys His Ile Ile Ser Pro Asn Pro
 640                 645                 650                 655

 cac gtg agg caa gca gcc tgc atc tgg ctc ctt tcc ctt gtc agg aag     2315
 His Val Arg Gln Ala Ala Cys Ile Trp Leu Leu Ser Leu Val Arg Lys
                 660                 665                 670

 cta agt acc cac aaa gaa gtg aag tct cat ctt aaa gaa att caa agt     2363
 Leu Ser Thr His Lys Glu Val Lys Ser His Leu Lys Glu Ile Gln Ser
             675                 680                 685

 gca ttt gtt tca gtt cta tca gaa aat gat gaa ctt agc caa gat gtt     2411
 Ala Phe Val Ser Val Leu Ser Glu Asn Asp Glu Leu Ser Gln Asp Val
         690                 695                 700

 gca tca aag ggc ctt ggg ttg gtt tat gaa cta ggc aat gaa caa gat     2459
 Ala Ser Lys Gly Leu Gly Leu Val Tyr Glu Leu Gly Asn Glu Gln Asp
     705                 710                 715

 caa cag gaa ttg gtt tct aca ctt gtg gaa aca ctt atg act ggc aaa     2507
 Gln Gln Glu Leu Val Ser Thr Leu Val Glu Thr Leu Met Thr Gly Lys
 720                 725                 730                 735

 aga gtt aaa cat gaa gtt tct gga gag aca gtg gta ttt caa ggg gga     2555
 Arg Val Lys His Glu Val Ser Gly Glu Thr Val Val Phe Gln Gly Gly
                 740                 745                 750

 gct ctt ggc aaa aca cca gat ggt cag ggc ctt tct act tac aag gaa     2603
 Ala Leu Gly Lys Thr Pro Asp Gly Gln Gly Leu Ser Thr Tyr Lys Glu
             755                 760                 765

 ctt tgt tct ctg gca agt gat ctt agc cag cca gat ctg gtg tat aaa     2651
 Leu Cys Ser Leu Ala Ser Asp Leu Ser Gln Pro Asp Leu Val Tyr Lys
         770                 775                 780

 ttt atg aat tta gcc aac cat cat gca atg tgg aac tct agg aag ggt     2699
 Phe Met Asn Leu Ala Asn His His Ala Met Trp Asn Ser Arg Lys Gly
     785                 790                 795

 gct gct ttt ggt ttt aat gta att gct acc aga gct gga gag cag ctg     2747
 Ala Ala Phe Gly Phe Asn Val Ile Ala Thr Arg Ala Gly Glu Gln Leu
 800                 805                 810                 815

 gct cct ttt ctg cct cag cta gtt cct cga ctt tat cgt tac cag ttt     2795
 Ala Pro Phe Leu Pro Gln Leu Val Pro Arg Leu Tyr Arg Tyr Gln Phe
                 820                 825                 830

 gat ccc aac ctt ggc att cga cag gcc atg aca agt att tgg aat gcg     2843
 Asp Pro Asn Leu Gly Ile Arg Gln Ala Met Thr Ser Ile Trp Asn Ala
             835                 840                 845

 ttg gtc act gac aaa tcc atg gtg gat aaa tat ttg aaa gaa att ctt     2891
 Leu Val Thr Asp Lys Ser Met Val Asp Lys Tyr Leu Lys Glu Ile Leu
         850                 855                 860

 caa gat ttg gtt aag aac ctt aca agc aat atg tgg cga gtt cga gaa     2939
 Gln Asp Leu Val Lys Asn Leu Thr Ser Asn Met Trp Arg Val Arg Glu
     865                 870                 875

 tcc agc tgt tta gct ttg aat gat tta ttg aga gga aga ccc tta gat     2987
 Ser Ser Cys Leu Ala Leu Asn Asp Leu Leu Arg Gly Arg Pro Leu Asp
 880                 885                 890                 895

 gac atc att gat aaa ctt cca gaa att tgg gaa acg ctt ttt aga gta     3035
 Asp Ile Ile Asp Lys Leu Pro Glu Ile Trp Glu Thr Leu Phe Arg Val
                 900                 905                 910

 caa gat gat atc aag gaa tct gta cga aaa gcg gca gaa cta gct ctg     3083
 Gln Asp Asp Ile Lys Glu Ser Val Arg Lys Ala Ala Glu Leu Ala Leu
             915                 920                 925

 aaa act ctg agc aag gtc tgt gtg aaa atg tgt gac cct gcc aaa gga     3131
 Lys Thr Leu Ser Lys Val Cys Val Lys Met Cys Asp Pro Ala Lys Gly
         930                 935                 940

 gca gct ggc cag aga acc atc gct gcc ctt ctg cct tgc ctt ctg gac     3179
 Ala Ala Gly Gln Arg Thr Ile Ala Ala Leu Leu Pro Cys Leu Leu Asp
     945                 950                 955

 aaa gga atg atg agc acc gtg acg gaa gtt cga gcc ctc agc att aac     3227
 Lys Gly Met Met Ser Thr Val Thr Glu Val Arg Ala Leu Ser Ile Asn
 960                 965                 970                 975

 acc ctt gtg aag atc agc aaa agt gca gga gcc atg ttg aaa ccg cat     3275
 Thr Leu Val Lys Ile Ser Lys Ser Ala Gly Ala Met Leu Lys Pro His
                 980                 985                 990

 gca cca aaa ctc att cca gct ctg cta gag tcc tta agt gta ttg gag     3323
 Ala Pro Lys Leu Ile Pro Ala Leu Leu Glu Ser Leu Ser Val Leu Glu
             995                1000                1005

 ccc caa gtt ctc aat tat ttg agc ctc cgg gcg aca gag caa gaa aag     3371
 Pro Gln Val Leu Asn Tyr Leu Ser Leu Arg Ala Thr Glu Gln Glu Lys
        1010                1015                1020

 gct gcg atg gat agt gct cgg ctt agt gct gcc aaa tct tct cca atg     3419
 Ala Ala Met Asp Ser Ala Arg Leu Ser Ala Ala Lys Ser Ser Pro Met
    1025                1030                1035

 atg gaa aca atc aac atg tgc ctg caa tac ctt gat gtg tca gtg ctg     3467
 Met Glu Thr Ile Asn Met Cys Leu Gln Tyr Leu Asp Val Ser Val Leu
1040                1045                1050                1055

 ggc gag cta gtt cct agg ttg tgt gaa ctg atc aga agt ggt gta ggt     3515
 Gly Glu Leu Val Pro Arg Leu Cys Glu Leu Ile Arg Ser Gly Val Gly
                1060                1065                1070

 ctt gga act aag ggt ggc tgt gcc agt gtc att gtg tca tta act act     3563
 Leu Gly Thr Lys Gly Gly Cys Ala Ser Val Ile Val Ser Leu Thr Thr
            1075                1080                1085

 cag tgt cct cag gac cta aca cct tac tca ggt aaa ctt atg agt gct     3611
 Gln Cys Pro Gln Asp Leu Thr Pro Tyr Ser Gly Lys Leu Met Ser Ala
        1090                1095                1100

 ttg ctg agt ggc ctg aca gat cgg aac agt gtg att cag aaa tct tgt     3659
 Leu Leu Ser Gly Leu Thr Asp Arg Asn Ser Val Ile Gln Lys Ser Cys
    1105                1110                1115

 gca ttt gct atg ggc cat tta gtt cgg acc tca cgg gat agc agc act     3707
 Ala Phe Ala Met Gly His Leu Val Arg Thr Ser Arg Asp Ser Ser Thr
1120                1125                1130                1135

 gaa aaa ctc ctg cag aag ctc aat ggg tgg tat atg gag aaa gaa gaa     3755
 Glu Lys Leu Leu Gln Lys Leu Asn Gly Trp Tyr Met Glu Lys Glu Glu
                1140                1145                1150

 cct atc tac aag acc tct tgt gct ttg act att cat gct att gga cga     3803
 Pro Ile Tyr Lys Thr Ser Cys Ala Leu Thr Ile His Ala Ile Gly Arg
            1155                1160                1165

 tac agc cct gat gta tta aag aat cat gca aaa gaa gtc ctg cct ctg     3851
 Tyr Ser Pro Asp Val Leu Lys Asn His Ala Lys Glu Val Leu Pro Leu
        1170                1175                1180

 gca ttt tta ggc atg cat gaa att gct gat gag gag aaa tcc gaa aaa     3899
 Ala Phe Leu Gly Met His Glu Ile Ala Asp Glu Glu Lys Ser Glu Lys
    1185                1190                1195

 gaa gaa tgt aat tta tgg acc gaa gtg tgg cag gaa aac gta cct gga     3947
 Glu Glu Cys Asn Leu Trp Thr Glu Val Trp Gln Glu Asn Val Pro Gly
1200                1205                1210                1215

 tcc ttt ggt ggc att cga tta tac ctg cag gag tta att act att acc     3995
 Ser Phe Gly Gly Ile Arg Leu Tyr Leu Gln Glu Leu Ile Thr Ile Thr
                1220                1225                1230

 cag aag gct ttg cag tct cag tcc tgg aaa atg aaa gcc cag ggt gca     4043
 Gln Lys Ala Leu Gln Ser Gln Ser Trp Lys Met Lys Ala Gln Gly Ala
            1235                1240                1245

 att gcc atg gca tca att gca aaa cag act agc tct cta gta cct cca     4091
 Ile Ala Met Ala Ser Ile Ala Lys Gln Thr Ser Ser Leu Val Pro Pro
        1250                1255                1260

 tat ctc gga atg ata ctg acc gca ttg ctg caa ggc ctg gct gga aga     4139
 Tyr Leu Gly Met Ile Leu Thr Ala Leu Leu Gln Gly Leu Ala Gly Arg
    1265                1270                1275

 acg tgg gca gga aag gag gag cta ttg aaa gcc att gcc tgt gtg gtg     4187
 Thr Trp Ala Gly Lys Glu Glu Leu Leu Lys Ala Ile Ala Cys Val Val
1280                1285                1290                1295

 aca gct tgc agt gca gag ctg gaa aag tct gtg ccc aat caa ccc agc     4235
 Thr Ala Cys Ser Ala Glu Leu Glu Lys Ser Val Pro Asn Gln Pro Ser
                1300                1305                1310

 aca aat gaa att ctt caa gct gtt ctg aag gaa tgt agc aaa gag aat     4283
 Thr Asn Glu Ile Leu Gln Ala Val Leu Lys Glu Cys Ser Lys Glu Asn
            1315                1320                1325

 gtc aaa tac aag att gta gca atc agc tgt gca gct gat atc ttg aag     4331
 Val Lys Tyr Lys Ile Val Ala Ile Ser Cys Ala Ala Asp Ile Leu Lys
        1330                1335                1340

 gcc acc aaa gag gac aga ttc cag gag ttc tct aac att gtc ata cct     4379
 Ala Thr Lys Glu Asp Arg Phe Gln Glu Phe Ser Asn Ile Val Ile Pro
    1345                1350                1355

 ctc atc aag aag aac tca ctt gaa agc agt ggg gtc cgg aca acc aaa     4427
 Leu Ile Lys Lys Asn Ser Leu Glu Ser Ser Gly Val Arg Thr Thr Lys
1360                1365                1370                1375

 aat gaa gag gag aat gaa aag gaa aag gag ctc cag ctg gaa tat ctg     4475
 Asn Glu Glu Glu Asn Glu Lys Glu Lys Glu Leu Gln Leu Glu Tyr Leu
                1380                1385                1390

 ctg ggt gcc ttt gaa agc ctg ggc aaa gcc tgg ccg cga aac gcg gag     4523
 Leu Gly Ala Phe Glu Ser Leu Gly Lys Ala Trp Pro Arg Asn Ala Glu
            1395                1400                1405

 acc caa cgt tgt tat cgt cag gag ctg tgc aaa ctg atg tgt gaa cgg     4571
 Thr Gln Arg Cys Tyr Arg Gln Glu Leu Cys Lys Leu Met Cys Glu Arg
        1410                1415                1420

 cta aaa ctc agc acg tgg aaa gtg cag cta gga gtc ctg caa tca atg     4619
 Leu Lys Leu Ser Thr Trp Lys Val Gln Leu Gly Val Leu Gln Ser Met
    1425                1430                1435

 aat gcc ttt ttt cag ggg tta atg ctt ttg gaa gaa gaa cat gcc gat     4667
 Asn Ala Phe Phe Gln Gly Leu Met Leu Leu Glu Glu Glu His Ala Asp
1440                1445                1450                1455

 cct gag gct ttg gct gaa att ctg ctt gaa act tgt aaa tca atc aca     4715
 Pro Glu Ala Leu Ala Glu Ile Leu Leu Glu Thr Cys Lys Ser Ile Thr
                1460                1465                1470

 tat tct tta gaa aat aag acc tac tca tct gtg aga aca gaa gct tta     4763
 Tyr Ser Leu Glu Asn Lys Thr Tyr Ser Ser Val Arg Thr Glu Ala Leu
            1475                1480                1485

 tct gtg ata gaa ttg ctg ctt aaa aaa ctt gaa gaa tct aaa cag tgg     4811
 Ser Val Ile Glu Leu Leu Leu Lys Lys Leu Glu Glu Ser Lys Gln Trp
        1490                1495                1500

 gaa tgt ttg aca tct gaa tgc aga gtg ctc cta att gag tct tta gct     4859
 Glu Cys Leu Thr Ser Glu Cys Arg Val Leu Leu Ile Glu Ser Leu Ala
    1505                1510                1515

 act atg gag cca gac agc aga cct gaa ctg cag gag aaa gca gcg tta     4907
 Thr Met Glu Pro Asp Ser Arg Pro Glu Leu Gln Glu Lys Ala Ala Leu
1520                1525                1530                1535

 ctg aag aaa aca ctt gaa aat ctg gaa taaat tagaagggga agaaacaaac     4959
 Leu Lys Lys Thr Leu Glu Asn Leu Glu 
                1540

 aagtgccatg ttcattgggg gttgaagtgg tggtgttctt tgaaaaacca agtgggaaaa   5019

 agtaaagatt aatctgtagc atgcatcatt ccttggctga aataaaaaga aaaagcctta   5079

 aattttgttc cttattagct ttattttact ttatgttttt aaagtatctg ggctgagtga   5139

 gcttaatgga accttggatg tttgaggggt ggttgtaaag gaaactggca gaaatagtta   5199

 ctaaaagagt tcaagctgtt attaaaggaa ttaatagaca gagttgcaga gcaagctgga   5259

 taaaaatctt agaactgcat tcaaattagt tatttcagga aggggcccta taaataactt   5319

 attttaacct ccctcttaca cctgaagaaa taggaagctg tgtcatctca gaggctttct   5379

 gaggcctgtg ccaaagtcag aacccaggtg tttaatgtct ggccctggat actttctttt   5439

 atggccatct gccaaatcag tgctaacccc ggcttaccca agaaacttcc aagatgaggt   5499

 acgtttaggg tggcacacag cagtctttgt gccagaacta aactgaccct taccattggg   5559

 tttctgaaag ccagaagcta aacattgtct tgtcatgtgt ttaggtggtt gatttggaga   5619

 aaatgattgt ttagcatctt tacagatgga gaggacagag tcagtctcct tcggataatt   5679

 ccaatcgtct tccttttaca ggtggataaa gtagattagg acaagatcac acattctatc   5739

 tgtgtctgtg gctgcatatt ttgcaaaacc agaaacaaaa tcgcagactg ccgtggttta   5799

 gaccatttat aatgtcaaaa ctgtaatgac aaatttctgt tcacttttat gctaccagta   5859

 tgactttata ggggagaagg aaagcctttt aattagccac ctgggaatta ctcttttaaa   5919

 aaatgccttt tctcaaaaga acatgatacc actccaagta aatcattgcc actaggggtt   5979

 ttcctccttc cttctgttgc ccatgcccct gcctgaaagt gtagggtaag aggaaaaaca   6039

 agtaaaacct tagtgttgat ggtaaactga gaactctgta gcttaccttg gattccagag   6099

 cagaagactg gtttacattc agtactcatc cttattgacg ttaacaccag gaatctccat   6159

 gtttattatt tttcgtggaa actccatgtt tattattttt ggtggtctct attgaccaat   6219

 gtatttcaaa cttttttgac tgcaagtcat aataaaaata actttttaca tcacgaccca   6279

 gaaaaaaaa                                                           6288




      <210> 55
      <211> 2004
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(1626)

      <400> 55
 taagcttgcg gccgcttccg actcagcctc ttcagcgacc tgcccgagga cacggagttg     60

 cagaggaagc tagaccatga gatccgg    atg agg gaa ggg gcc tgt aag ctg     111
                                  Met Arg Glu Gly Ala Cys Lys Leu
                                    1               5

 ctg gca gcc tgc tcc cag cga gag cag gct ctg gag gcc acc aag agc      159
 Leu Ala Ala Cys Ser Gln Arg Glu Gln Ala Leu Glu Ala Thr Lys Ser
      10                  15                  20

 ctg cta gtg tgc aac agc cgc atc ctc agc tac atg ggc gag ctg cag      207
 Leu Leu Val Cys Asn Ser Arg Ile Leu Ser Tyr Met Gly Glu Leu Gln
  25                  30                  35                  40

 cgg cgc aag gag gcg cag gtg ctg ggg aag aca agc cgg cgg cct tct      255
 Arg Arg Lys Glu Ala Gln Val Leu Gly Lys Thr Ser Arg Arg Pro Ser
                  45                  50                  55

 gac agt ggc ccg ccc gct gag cgc tcc ccc tgc cgc ggc cgg gtc tgc      303
 Asp Ser Gly Pro Pro Ala Glu Arg Ser Pro Cys Arg Gly Arg Val Cys
              60                  65                  70

 atc tct gac ctc cgg att cca ctc atg tgg aag gac aca gaa tat ttc      351
 Ile Ser Asp Leu Arg Ile Pro Leu Met Trp Lys Asp Thr Glu Tyr Phe
          75                  80                  85

 aag aac aaa ggt gac ttg cac cgc tgg gct gtg ttc ctg ctg ctg cag      399
 Lys Asn Lys Gly Asp Leu His Arg Trp Ala Val Phe Leu Leu Leu Gln
      90                  95                 100

 ctg ggg gaa cac atc cag gac aca gag atg atc cta gtg gac agg acc      447
 Leu Gly Glu His Ile Gln Asp Thr Glu Met Ile Leu Val Asp Arg Thr
 105                 110                 115                 120

 ctc aca gac atc tcc ttt cag agc aat gtg ctc ttc gct gag gcg ggg      495
 Leu Thr Asp Ile Ser Phe Gln Ser Asn Val Leu Phe Ala Glu Ala Gly
                 125                 130                 135

 cca gac ttt gaa ctg cgg tta gag ctg tat ggg gcc tgt gtg gaa gaa      543
 Pro Asp Phe Glu Leu Arg Leu Glu Leu Tyr Gly Ala Cys Val Glu Glu
             140                 145                 150

 gag ggg gcc ctg act ggc ggc ccc aag agg ctt gcc acc aaa ctc agc      591
 Glu Gly Ala Leu Thr Gly Gly Pro Lys Arg Leu Ala Thr Lys Leu Ser
         155                 160                 165

 agc tcc ctg ggc cgc tcc tca ggg agg cgt gtc cgg gca tcg ctg gac      639
 Ser Ser Leu Gly Arg Ser Ser Gly Arg Arg Val Arg Ala Ser Leu Asp
     170                 175                 180

 agt gct ggg ggt tca ggg agc agt ccc atc ttg ctc ccc acc cca gtt      687
 Ser Ala Gly Gly Ser Gly Ser Ser Pro Ile Leu Leu Pro Thr Pro Val
 185                 190                 195                 200

 gtt ggt ggt cct cgt tac cac ctc ttg gct cac acc aca ctc acc ctg      735
 Val Gly Gly Pro Arg Tyr His Leu Leu Ala His Thr Thr Leu Thr Leu
                 205                 210                 215

 gca gca gtg caa gat gga ttc cgc aca cat gac ctc acc ctt gcc agt      783
 Ala Ala Val Gln Asp Gly Phe Arg Thr His Asp Leu Thr Leu Ala Ser
             220                 225                 230

 cat gag gag aac cct gcc tgg ctg ccc ctt tat ggt agc gtg tgt tgc      831
 His Glu Glu Asn Pro Ala Trp Leu Pro Leu Tyr Gly Ser Val Cys Cys
         235                 240                 245

 cgt ctg gca gct cag cct ctc tgc atg act cag ccc act gca agt ggt      879
 Arg Leu Ala Ala Gln Pro Leu Cys Met Thr Gln Pro Thr Ala Ser Gly
     250                 255                 260

 acc ctc agg gtg cag caa gct ggg gag atg cag aac tgg gca caa gtg      927
 Thr Leu Arg Val Gln Gln Ala Gly Glu Met Gln Asn Trp Ala Gln Val
 265                 270                 275                 280

 cat gga gtt ctg aaa ggc aca aac ctc ttc tgt tac cgg caa cct gag      975
 His Gly Val Leu Lys Gly Thr Asn Leu Phe Cys Tyr Arg Gln Pro Glu
                 285                 290                 295

 gat gca gac act ggg gaa gag ccg ctg ctt act att gct gtc aac aag     1023
 Asp Ala Asp Thr Gly Glu Glu Pro Leu Leu Thr Ile Ala Val Asn Lys
             300                 305                 310

 gag act cga gtc cgg gca ggg gag ctg gac cag gct cta gga cgg ccc     1071
 Glu Thr Arg Val Arg Ala Gly Glu Leu Asp Gln Ala Leu Gly Arg Pro
         315                 320                 325

 ttc acc cta agc atc agt aac cag tat ggg gat gat gag gtg aca cac     1119
 Phe Thr Leu Ser Ile Ser Asn Gln Tyr Gly Asp Asp Glu Val Thr His
     330                 335                 340

 acc ctt cag aca gaa agt cgg gaa gca ctg cag agc tgg atg gag gct     1167
 Thr Leu Gln Thr Glu Ser Arg Glu Ala Leu Gln Ser Trp Met Glu Ala
 345                 350                 355                 360

 ctg tgg cag ctt ttc ttt gac atg agc caa tgg aag cag tgc tgt gat     1215
 Leu Trp Gln Leu Phe Phe Asp Met Ser Gln Trp Lys Gln Cys Cys Asp
                 365                 370                 375

 gaa atc atg aaa att gaa act cct gct ccc cgg aaa cca ccc caa gca     1263
 Glu Ile Met Lys Ile Glu Thr Pro Ala Pro Arg Lys Pro Pro Gln Ala
             380                 385                 390

 ctg gca aag cag ggg tcc ttg tac cat gag atg gct att gag ccg ctg     1311
 Leu Ala Lys Gln Gly Ser Leu Tyr His Glu Met Ala Ile Glu Pro Leu
         395                 400                 405

 gat gac atc gca gcg gtg aca gac atc ctg acc cag cgg gag ggc gca     1359
 Asp Asp Ile Ala Ala Val Thr Asp Ile Leu Thr Gln Arg Glu Gly Ala
     410                 415                 420

 agg ctg gag aca ccc cca ccc tgg ctg gca atg ttt aca gac cag cct     1407
 Arg Leu Glu Thr Pro Pro Pro Trp Leu Ala Met Phe Thr Asp Gln Pro
 425                 430                 435                 440

 gcc ctg cct aac ccc tgc tcg cct gcc tca gtg gcc cca gcc cca gac     1455
 Ala Leu Pro Asn Pro Cys Ser Pro Ala Ser Val Ala Pro Ala Pro Asp
                 445                 450                 455

 tgg acc cac ccc ctg ccc tgg ggg aga ccc cga acc ttt tcc ctg gat     1503
 Trp Thr His Pro Leu Pro Trp Gly Arg Pro Arg Thr Phe Ser Leu Asp
             460                 465                 470

 gct gtc ccc cca gac cac tcc cct agg gct cgc tcg gtt gcc ccc ctc     1551
 Ala Val Pro Pro Asp His Ser Pro Arg Ala Arg Ser Val Ala Pro Leu
         475                 480                 485

 cca cct cag cga tcc cca cgg acc aga ggc ctc tgc agc aaa ggc caa     1599
 Pro Pro Gln Arg Ser Pro Arg Thr Arg Gly Leu Cys Ser Lys Gly Gln
     490                 495                 500

 cct cgc act tgg ctc cag tca cca gtg tgaga gagaaaggtg ctggcatagg     1651
 Pro Arg Thr Trp Leu Gln Ser Pro Val 
 505                 510

 atctgcccag aagagaaaat gacccatgcg cagttgggct ctggatacgg cgctgtctat   1711

 agcaagttgg ccagtctggc ctcctgttcc tctgctggac ctggggtagg ctgcaggggt   1771

 gggcagaagc ccctcttaaa ttgtggttgc catggtaccg agggactcat tcctggggct   1831

 cgctgggacc tccctaaacc cttcctggaa gaaaactgga accaactctg ccctacctcc   1891

 ctgcactaac cagctttgag gatggcactg aagaaccctt ggagcaaaca tacctccctt   1951

 gtgactccca catcaaccat taaagttatt taacagcaaa aaaaaaaaaa aag          2004




      <210> 56
      <211> 1643
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(1275)

      <400> 56
 acaccaaggc aggaggctag gaggtctaca aatagcgact gggtagctgg tgtgaacaca     60

 gggggtactg ggggggctta gcccccaagg aagaggacca gtttttcccc agcaccacca    120

 tcaaggcctc gaggctccca gctccctcta cagcctgtgg actgacttag ggaatcccga    180

 acg  atg aca gaa aag gag gtg ctg gag tcc cct aag ccc tcc ttc cca     228
      Met Thr Glu Lys Glu Val Leu Glu Ser Pro Lys Pro Ser Phe Pro
        1               5                  10                  15

 gca gag act cgg caa agt ggg cta cag cgg cta aag cag tta ctc agg      276
 Ala Glu Thr Arg Gln Ser Gly Leu Gln Arg Leu Lys Gln Leu Leu Arg
                  20                  25                  30

 aag ggt tct aca ggg aca aag gag atg gaa ctt ccc cca gag ccc cag      324
 Lys Gly Ser Thr Gly Thr Lys Glu Met Glu Leu Pro Pro Glu Pro Gln
              35                  40                  45

 gcc aat ggg gag gca gtg gga gct ggg ggt ggg ccc atc tac tac atc      372
 Ala Asn Gly Glu Ala Val Gly Ala Gly Gly Gly Pro Ile Tyr Tyr Ile
          50                  55                  60

 tat gag gaa gag gaa gag gaa gaa gag gag gag gag gag cca ccc cca      420
 Tyr Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Pro Pro
      65                  70                  75

 gaa cct cct aag ctg gtc aac gat aag ccc cac aaa ttc aaa gat cac      468
 Glu Pro Pro Lys Leu Val Asn Asp Lys Pro His Lys Phe Lys Asp His
  80                  85                  90                  95

 ttc ttc aag aag cca aag ttc tgt gat gtc tgt gcc cgg atg att gtt      516
 Phe Phe Lys Lys Pro Lys Phe Cys Asp Val Cys Ala Arg Met Ile Val
                 100                 105                 110

 ctc aac aac aag ttt ggg ctt cgc tgt aag aac tgc aaa acc aac atc      564
 Leu Asn Asn Lys Phe Gly Leu Arg Cys Lys Asn Cys Lys Thr Asn Ile
             115                 120                 125

 cat gaa cac tgt cag tcc tat gtg gaa atg cag aga tgc ttc ggc aag      612
 His Glu His Cys Gln Ser Tyr Val Glu Met Gln Arg Cys Phe Gly Lys
         130                 135                 140

 atc cca cct ggt ttc cat cgg gcc tat agt tcc cca ctc tac agc aac      660
 Ile Pro Pro Gly Phe His Arg Ala Tyr Ser Ser Pro Leu Tyr Ser Asn
     145                 150                 155

 cag cag tac gct tgt gtc aaa gat ctc tct gct gcc aat cgc aat gat      708
 Gln Gln Tyr Ala Cys Val Lys Asp Leu Ser Ala Ala Asn Arg Asn Asp
 160                 165                 170                 175

 cct gtg ttt gaa acc ctg cgc act ggg gtg atc atg gca aac aag gaa      756
 Pro Val Phe Glu Thr Leu Arg Thr Gly Val Ile Met Ala Asn Lys Glu
                 180                 185                 190

 cgg aag aag gga cag gca gat aag aaa aat cct gta gca gcc atg atg      804
 Arg Lys Lys Gly Gln Ala Asp Lys Lys Asn Pro Val Ala Ala Met Met
             195                 200                 205

 gag gag gag cca gag tcg gcc aga cca gag gaa ggc aaa ccc cag gat      852
 Glu Glu Glu Pro Glu Ser Ala Arg Pro Glu Glu Gly Lys Pro Gln Asp
         210                 215                 220

 gga aac cct gaa ggg gat aag aag gct gag aag aag aca cct gat gac      900
 Gly Asn Pro Glu Gly Asp Lys Lys Ala Glu Lys Lys Thr Pro Asp Asp
     225                 230                 235

 aag cac aag cag cct ggc ttc cag cag tct cat tac ttt gtg gct ctc      948
 Lys His Lys Gln Pro Gly Phe Gln Gln Ser His Tyr Phe Val Ala Leu
 240                 245                 250                 255

 tat cgg ttc aaa gcc ctg gag aag gac gat ctg gat ttc ccg cca gga      996
 Tyr Arg Phe Lys Ala Leu Glu Lys Asp Asp Leu Asp Phe Pro Pro Gly
                 260                 265                 270

 gag aag atc aca gtc att gat gac tcc aat gaa gaa tgg tgg cgg ggg     1044
 Glu Lys Ile Thr Val Ile Asp Asp Ser Asn Glu Glu Trp Trp Arg Gly
             275                 280                 285

 aaa atc ggg gag aag gtc gga ttt ttc cct cca aac ttc atc att cgg     1092
 Lys Ile Gly Glu Lys Val Gly Phe Phe Pro Pro Asn Phe Ile Ile Arg
         290                 295                 300

 gtc cgg gct gga gaa cgt gtg cac cgc gtg acg aga tcc ttc gtg ggg     1140
 Val Arg Ala Gly Glu Arg Val His Arg Val Thr Arg Ser Phe Val Gly
     305                 310                 315

 aac cgc gag ata ggg cag atc act ctc aag aag gac cag atc gtg gtg     1188
 Asn Arg Glu Ile Gly Gln Ile Thr Leu Lys Lys Asp Gln Ile Val Val
 320                 325                 330                 335

 cag aaa gga gac gaa gcg ggc ggc tac gtc aag gtc tac acc ggc cgc     1236
 Gln Lys Gly Asp Glu Ala Gly Gly Tyr Val Lys Val Tyr Thr Gly Arg
                 340                 345                 350

 aag gtg ggg ctg ttt ccc acc gac ttt cta gag gaa att taggtgtgcg      1285
 Lys Val Gly Leu Phe Pro Thr Asp Phe Leu Glu Glu Ile 
             355                 360

 ggcgcctgca agcgggagac acccacaccc cattctgggc gggcccagtg gagtttgggg   1345

 aggggggcga aagcaacggg actgctggga gaggaggggt aggaaggccc gcctgagcgc   1405

 gacggggctt ccgggaaggg actggttctc gcccccttcc ccagcctggg gcctcggata   1465

 cctgctgccc agagcagccc ggacccgaaa cctttcaggc cccgcttgca agagctggaa   1525

 aaaaacgcgt atctactagg aggagccagg gactggggcg gggggcgggg gcgagggagg   1585

 gcgaactgtc gaatgttgcg aatttattaa acttttgaca aaacttaaaa aaaaaaaa     1643




      <210> 57
      <211> 474
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(459)

      <400> 57
 gcacagactc agagagaacc cacc   atg gtg ctg tct cct gcc gac aag acc      51
                              Met Val Leu Ser Pro Ala Asp Lys Thr
                                1               5

 aac gtc aag gcc gcc tgg ggt aag gtc ggc gcg cac gct ggc gag tat       99
 Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu Tyr
  10                  15                  20                  25

 ggt gcg gag gcc ctg gag agg atg ttc ctg tcc ttc ccc acc acc aag      147
 Gly Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr Lys
                  30                  35                  40

 acc tac ttc ccg cac ttc gac ctg agc cac ggc tct gcc cag gtt aag      195
 Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Gln Val Lys
              45                  50                  55

 ggc cac ggc aag aag gtg gcc gac gcg ctg acc aac gcc gtg gcc aac      243
 Gly His Gly Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala Asn
          60                  65                  70

 gtg gga cga cat gcc caa cgc gct gtc cgc cct gag cga cct gca cgc      291
 Val Gly Arg His Ala Gln Arg Ala Val Arg Pro Glu Arg Pro Ala Arg
      75                  80                  85

 gca caa gct tcg ggt gga ccc ggt caa ctt caa gct cct aag cca ctg      339
 Ala Gln Ala Ser Gly Gly Pro Gly Gln Leu Gln Ala Pro Lys Pro Leu
  90                  95                 100                 105

 cct gct ggt gac cct ggg ccg ccc acc tcc ccg ccg agt tca ccc cct      387
 Pro Ala Gly Asp Pro Gly Pro Pro Thr Ser Pro Pro Ser Ser Pro Pro
                 110                 115                 120

 gcg gtt gca acg ttc tcc ctg ggg aca agt tcc tgg ttt ttt gtt gag      435
 Ala Val Ala Thr Phe Ser Leu Gly Thr Ser Ser Trp Phe Phe Val Glu
             125                 130                 135

 cac cgt gtt gac tgc aaa tac ctt taaagtttga gcttg                     474
 His Arg Val Asp Cys Lys Tyr Leu 
         140                 145





      <210> 58
      <211> 4843
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (581)..(4321)

      <400> 58
 cccgaggctc atttccatgc aaagagcctg acatcagagc accttttgtt gctaaacgct     60

 ttctttagcc tcgagggaga gagtcatgtg gagctggaag agctcatttt gaagagaggg    120

 gtcccgggga gctccctcca agatctagag gctccgcggc cacccctgcc gggtcctgcc    180

 aagacttgct agaaggaacg agtcgcgtgc cttagttagt tggttcccgt cacaggaaga    240

 aacgcctttg cagtgggttt aattgcttct gggccgagcg aattccccgc cgtacaactc    300

 agtggtgcgg actttgcctc ctgctaccct gttgctgcgc cgagcggggt gggaaagttt    360

 ctggagttgt cagtcgcgca gcccgtggcc acctagaccc gaggtgcggg cgcctgcgaa    420

 gggcccccgc ggggtggccg gggccgccgg ggcatgcagc gcgggggcgc ggctcggtga    480

 cgccgcgggc ggggacccgg catccgggca ggctgcgcgc gggtgcgggg cgagggcgcc    540

 gcggggactg ggacgcacgg cccgcgcgcg ggacacggcc  atg gag gac gcg gga     595
                                              Met Glu Asp Ala Gly
                                                1               5

 gca gct ggc ccg ggg ccg gag cct gag ccc gag ccc gag ccg gag ccc      643
 Ala Ala Gly Pro Gly Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro
                  10                  15                  20

 gag ccc gcg ccg gag ccg gaa ccg gag ccc aag ccg ggt gct ggc aca      691
 Glu Pro Ala Pro Glu Pro Glu Pro Glu Pro Lys Pro Gly Ala Gly Thr
              25                  30                  35

 tcc gag gcg ttc tcc cga ctc tgg acc gac gtg atg ggt atc ctg gac      739
 Ser Glu Ala Phe Ser Arg Leu Trp Thr Asp Val Met Gly Ile Leu Asp
          40                  45                  50

 ggt tca ctg gga aac atc gat gac ctg gcg cag cag tat gca gat tat      787
 Gly Ser Leu Gly Asn Ile Asp Asp Leu Ala Gln Gln Tyr Ala Asp Tyr
      55                  60                  65

 tac aac acc tgt ttc tcc gac gtg tgc gag agg atg gag gag ctg cgg      835
 Tyr Asn Thr Cys Phe Ser Asp Val Cys Glu Arg Met Glu Glu Leu Arg
  70                  75                  80                  85

 aaa cgg cgg gtt tcc cag gac ctg gaa gtg gag aaa ccc gat gct agc      883
 Lys Arg Arg Val Ser Gln Asp Leu Glu Val Glu Lys Pro Asp Ala Ser
                  90                  95                 100

 ccc acg tca ctt cag ctg cgg tcc cag atc gaa gag tcg ctt ggc ttc      931
 Pro Thr Ser Leu Gln Leu Arg Ser Gln Ile Glu Glu Ser Leu Gly Phe
             105                 110                 115

 tgt agc gcc gtg tca acc cca gaa gtg gaa aga aag aac cct ctt cat      979
 Cys Ser Ala Val Ser Thr Pro Glu Val Glu Arg Lys Asn Pro Leu His
         120                 125                 130

 aaa tca aac tca gaa gac agc tct gta gga aaa gga gac tgg aag aag     1027
 Lys Ser Asn Ser Glu Asp Ser Ser Val Gly Lys Gly Asp Trp Lys Lys
     135                 140                 145

 aaa aat aag tat ttc tgg cag aac ttc cga aag aac cag aaa gga ata     1075
 Lys Asn Lys Tyr Phe Trp Gln Asn Phe Arg Lys Asn Gln Lys Gly Ile
 150                 155                 160                 165

 atg aga cag act tca aaa gga gaa gac gtt ggt tat gtt gcc agt gaa     1123
 Met Arg Gln Thr Ser Lys Gly Glu Asp Val Gly Tyr Val Ala Ser Glu
                 170                 175                 180

 ata acg atg agc gat gag gag cgg att cag cta atg atg atg gtc aaa     1171
 Ile Thr Met Ser Asp Glu Glu Arg Ile Gln Leu Met Met Met Val Lys
             185                 190                 195

 gaa aag atg atc aca att gag gaa gca ctt gct agg ctc aag gaa tac     1219
 Glu Lys Met Ile Thr Ile Glu Glu Ala Leu Ala Arg Leu Lys Glu Tyr
         200                 205                 210

 gag gcc cag cac cgg cag tcg gct gcc ctg gac cct gct gac tgg cca     1267
 Glu Ala Gln His Arg Gln Ser Ala Ala Leu Asp Pro Ala Asp Trp Pro
     215                 220                 225

 gat ggt tct tac cca acg ttt gat ggc tca tca aac tgc aat tca aga     1315
 Asp Gly Ser Tyr Pro Thr Phe Asp Gly Ser Ser Asn Cys Asn Ser Arg
 230                 235                 240                 245

 gaa caa tcg gat gat gag act gag gag tcg gtg aag ttt aag agg tta     1363
 Glu Gln Ser Asp Asp Glu Thr Glu Glu Ser Val Lys Phe Lys Arg Leu
                 250                 255                 260

 cac aag ctg gta aac tcc act cgc aga gtc aga aag aaa cta att agg     1411
 His Lys Leu Val Asn Ser Thr Arg Arg Val Arg Lys Lys Leu Ile Arg
             265                 270                 275

 gtg gaa gaa atg aaa aaa ccc agc act gaa ggt ggg gag gag cac gtg     1459
 Val Glu Glu Met Lys Lys Pro Ser Thr Glu Gly Gly Glu Glu His Val
         280                 285                 290

 ttt gag aat tcg ccg gtc ctg gat gaa cgg tcc gcc ctc tac tct ggc     1507
 Phe Glu Asn Ser Pro Val Leu Asp Glu Arg Ser Ala Leu Tyr Ser Gly
     295                 300                 305

 gtg cac aag aag ccc ctt ttc ttt gat ggc tct cct gag aaa cct ccc     1555
 Val His Lys Lys Pro Leu Phe Phe Asp Gly Ser Pro Glu Lys Pro Pro
 310                 315                 320                 325

 gaa gat gac tca gac tct ctc acc acg tct cca tcc tcc agc agc ctg     1603
 Glu Asp Asp Ser Asp Ser Leu Thr Thr Ser Pro Ser Ser Ser Ser Leu
                 330                 335                 340

 gac acc tgg ggg gct ggc cgg aag ttg gtc aaa acc ttc agc aaa gga     1651
 Asp Thr Trp Gly Ala Gly Arg Lys Leu Val Lys Thr Phe Ser Lys Gly
             345                 350                 355

 gag agc cgg ggc ctg att aag ccc ccc aag aag atg ggg aca ttc ttc     1699
 Glu Ser Arg Gly Leu Ile Lys Pro Pro Lys Lys Met Gly Thr Phe Phe
         360                 365                 370

 tcc tac cca gaa gaa gaa aag gcc cag aaa gtg tcc cgc tcc ctc acc     1747
 Ser Tyr Pro Glu Glu Glu Lys Ala Gln Lys Val Ser Arg Ser Leu Thr
     375                 380                 385

 gag ggg gag atg aag aag ggt ctc ggg tcc cta agc cac ggg aga acc     1795
 Glu Gly Glu Met Lys Lys Gly Leu Gly Ser Leu Ser His Gly Arg Thr
 390                 395                 400                 405

 tgc agt ttt gga gga ttt gac ttg acg aat cgc tct ctg cac gtt ggc     1843
 Cys Ser Phe Gly Gly Phe Asp Leu Thr Asn Arg Ser Leu His Val Gly
                 410                 415                 420

 agt aat aat tct gac cca atg ggt aaa gaa gga gac ttt gtg tac aaa     1891
 Ser Asn Asn Ser Asp Pro Met Gly Lys Glu Gly Asp Phe Val Tyr Lys
             425                 430                 435

 gaa gtc atc aaa tca cct act gcc tct cgc atc tct ctt ggg aaa aag     1939
 Glu Val Ile Lys Ser Pro Thr Ala Ser Arg Ile Ser Leu Gly Lys Lys
         440                 445                 450

 gtg aaa tca gtg aaa gag acg atg aga aag aga atg tct aaa aaa tac     1987
 Val Lys Ser Val Lys Glu Thr Met Arg Lys Arg Met Ser Lys Lys Tyr
     455                 460                 465

 agc agc tct gtc tct gag cag gac tcg ggc ctt gat gga atg cct ggc     2035
 Ser Ser Ser Val Ser Glu Gln Asp Ser Gly Leu Asp Gly Met Pro Gly
 470                 475                 480                 485

 tcc cct ccg cct tca cag ccc gac ccc gaa cac ttg gac aag ccc aag     2083
 Ser Pro Pro Pro Ser Gln Pro Asp Pro Glu His Leu Asp Lys Pro Lys
                 490                 495                 500

 ctc aag gcc ggg ggt tct gta gaa agt ctt cgc agt tct ctc agt ggg     2131
 Leu Lys Ala Gly Gly Ser Val Glu Ser Leu Arg Ser Ser Leu Ser Gly
             505                 510                 515

 cag agc tcc atg agc ggt caa aca gtg agc acc act gat tcc tca acc     2179
 Gln Ser Ser Met Ser Gly Gln Thr Val Ser Thr Thr Asp Ser Ser Thr
         520                 525                 530

 agc aac cgg gaa agc gtc aag tcg gaa gat ggg gat gac gaa gag ccg     2227
 Ser Asn Arg Glu Ser Val Lys Ser Glu Asp Gly Asp Asp Glu Glu Pro
     535                 540                 545

 cct tac cga ggc ccg ttc tgc ggg cgt gcc agg gtg cac acc gac ttc     2275
 Pro Tyr Arg Gly Pro Phe Cys Gly Arg Ala Arg Val His Thr Asp Phe
 550                 555                 560                 565

 acc ccc agt ccc tat gac aca gac tca ctc aag ctc aag aaa gga gat     2323
 Thr Pro Ser Pro Tyr Asp Thr Asp Ser Leu Lys Leu Lys Lys Gly Asp
                 570                 575                 580

 atc atc gat ata atc agc aag cca ccc atg ggg acc tgg atg ggc ctg     2371
 Ile Ile Asp Ile Ile Ser Lys Pro Pro Met Gly Thr Trp Met Gly Leu
             585                 590                 595

 ctg aac aac aaa gtc ggc acg ttc aag ttc atc tac gtg gac gtg ctc     2419
 Leu Asn Asn Lys Val Gly Thr Phe Lys Phe Ile Tyr Val Asp Val Leu
         600                 605                 610

 agt gaa gac gag gag aaa ccc aaa cgc ccc acc agg agg cgt cgg aaa     2467
 Ser Glu Asp Glu Glu Lys Pro Lys Arg Pro Thr Arg Arg Arg Arg Lys
     615                 620                 625

 gga cga cca ccc cag ccc aag tct gtg gag gat ctc ctg gat cgg att     2515
 Gly Arg Pro Pro Gln Pro Lys Ser Val Glu Asp Leu Leu Asp Arg Ile
 630                 635                 640                 645

 aac cta aaa gag cac atg ccc act ttc ctg ttc aat gga tat gaa gat     2563
 Asn Leu Lys Glu His Met Pro Thr Phe Leu Phe Asn Gly Tyr Glu Asp
                 650                 655                 660

 ttg gac acc ttt aag ctg ctg gag gag gaa gac ttg gat gag tta aat     2611
 Leu Asp Thr Phe Lys Leu Leu Glu Glu Glu Asp Leu Asp Glu Leu Asn
             665                 670                 675

 atc agg gac ccg gaa cac aga gct gtt ctc ttg aca gca gtg gag ctg     2659
 Ile Arg Asp Pro Glu His Arg Ala Val Leu Leu Thr Ala Val Glu Leu
         680                 685                 690

 tta caa gag tat gac agt aac agc gac cag tca gga tcc cag gag aag     2707
 Leu Gln Glu Tyr Asp Ser Asn Ser Asp Gln Ser Gly Ser Gln Glu Lys
     695                 700                 705

 ctg ctc gtt gac agc cag ggc ctg agt gga tgc tca ccc cga gac tca     2755
 Leu Leu Val Asp Ser Gln Gly Leu Ser Gly Cys Ser Pro Arg Asp Ser
 710                 715                 720                 725

 gga tgc tac gaa agc agt gag aac ctg gaa aac ggc aag act cgg aaa     2803
 Gly Cys Tyr Glu Ser Ser Glu Asn Leu Glu Asn Gly Lys Thr Arg Lys
                 730                 735                 740

 gct agc ctc cta tct gcc aag tca tcc acc gag ccc agc ttg aag tct     2851
 Ala Ser Leu Leu Ser Ala Lys Ser Ser Thr Glu Pro Ser Leu Lys Ser
             745                 750                 755

 ttt agc aga aac cag ttg ggc aat tac cca aca ttg cct tta atg aaa     2899
 Phe Ser Arg Asn Gln Leu Gly Asn Tyr Pro Thr Leu Pro Leu Met Lys
         760                 765                 770

 tca ggg gat gca ctg aag cag gga cag gag gag ggc agg ctg ggt ggt     2947
 Ser Gly Asp Ala Leu Lys Gln Gly Gln Glu Glu Gly Arg Leu Gly Gly
     775                 780                 785

 ggc ctt gcc cca gac acg tcc aag agc tgt gac cca cct ggt gtg act     2995
 Gly Leu Ala Pro Asp Thr Ser Lys Ser Cys Asp Pro Pro Gly Val Thr
 790                 795                 800                 805

 ggt ttg aat aaa aac cga aga agc ctc cca gtt tcc atc tgc cgg agc     3043
 Gly Leu Asn Lys Asn Arg Arg Ser Leu Pro Val Ser Ile Cys Arg Ser
                 810                 815                 820

 tgt gag acc ctg gag ggc ccc cag act gtg gac act tgg ccc cga tcc     3091
 Cys Glu Thr Leu Glu Gly Pro Gln Thr Val Asp Thr Trp Pro Arg Ser
             825                 830                 835

 cat tcc ctg gat gac ctt caa gtg gag cct ggt gct gag caa gac gtg     3139
 His Ser Leu Asp Asp Leu Gln Val Glu Pro Gly Ala Glu Gln Asp Val
         840                 845                 850

 cct acc gag gtg aca gaa ccg ccc cct cag att gta cct gaa gtg cca     3187
 Pro Thr Glu Val Thr Glu Pro Pro Pro Gln Ile Val Pro Glu Val Pro
     855                 860                 865

 cag aag acg acc gcc tct tcc acg aag gcc cag ccc ctg gag caa gac     3235
 Gln Lys Thr Thr Ala Ser Ser Thr Lys Ala Gln Pro Leu Glu Gln Asp
 870                 875                 880                 885

 tct gct gtc gac aat gca ttg cta ctg acc caa agc aag aga ttt tct     3283
 Ser Ala Val Asp Asn Ala Leu Leu Leu Thr Gln Ser Lys Arg Phe Ser
                 890                 895                 900

 gaa cct cag aaa ttg aca act aag aaa ctg gag ggc tca atc gca gcc     3331
 Glu Pro Gln Lys Leu Thr Thr Lys Lys Leu Glu Gly Ser Ile Ala Ala
             905                 910                 915

 tct ggt cgc ggc ctg tca ccc cct cag tgt ttg ccc aga aac tat gat     3379
 Ser Gly Arg Gly Leu Ser Pro Pro Gln Cys Leu Pro Arg Asn Tyr Asp
         920                 925                 930

 gct cag cct cct gga gct aaa cac ggt tta gca agg acg cct ctg gag     3427
 Ala Gln Pro Pro Gly Ala Lys His Gly Leu Ala Arg Thr Pro Leu Glu
     935                 940                 945

 ggc cac aga aaa gga cac gag ttt gaa gga aca cac cat ccc ctg ggc     3475
 Gly His Arg Lys Gly His Glu Phe Glu Gly Thr His His Pro Leu Gly
 950                 955                 960                 965

 acc aaa gaa ggg gta gat gct gag cag aga atg cag ccc aaa att cca     3523
 Thr Lys Glu Gly Val Asp Ala Glu Gln Arg Met Gln Pro Lys Ile Pro
                 970                 975                 980

 tca cag cct cca cct gtt cct gcc aaa aag agc aga gaa cgc ctt gct     3571
 Ser Gln Pro Pro Pro Val Pro Ala Lys Lys Ser Arg Glu Arg Leu Ala
             985                 990                 995

 aac gga ctc cac cct gtt ccc atg ggc ccc agt ggg gcc ctc ccc agt     3619
 Asn Gly Leu His Pro Val Pro Met Gly Pro Ser Gly Ala Leu Pro Ser
        1000                1005                1010

 ccc gat gcg cca tgc ctg cca gtg aaa agg ggc agc ccc gcc agc ccc     3667
 Pro Asp Ala Pro Cys Leu Pro Val Lys Arg Gly Ser Pro Ala Ser Pro
    1015                1020                1025

 acc agc cct agc gac tgt ccc cca gca ctg gct ccc agg cct ctc tca     3715
 Thr Ser Pro Ser Asp Cys Pro Pro Ala Leu Ala Pro Arg Pro Leu Ser
1030                1035                1040                1045

 ggg cag gcg cct ggc agc cca cca agc aca agg ccg ccc ccc tgg ctc     3763
 Gly Gln Ala Pro Gly Ser Pro Pro Ser Thr Arg Pro Pro Pro Trp Leu
                1050                1055                1060

 tca gag ctc ccc gag aac aca agc ctc cag gag cac ggt gtg aag ctg     3811
 Ser Glu Leu Pro Glu Asn Thr Ser Leu Gln Glu His Gly Val Lys Leu
            1065                1070                1075

 ggc ccg gct ttg acc agg aag gtc tcc tgt gcc cgg gga gtg gat cta     3859
 Gly Pro Ala Leu Thr Arg Lys Val Ser Cys Ala Arg Gly Val Asp Leu
        1080                1085                1090

 gaa acg ctc act gaa aac aag ctg cac gct gaa ggc atc gat ctc acg     3907
 Glu Thr Leu Thr Glu Asn Lys Leu His Ala Glu Gly Ile Asp Leu Thr
    1095                1100                1105

 gag gag ccg tat tct gat aag cat ggc cgc tgt ggg att cct gaa gcc     3955
 Glu Glu Pro Tyr Ser Asp Lys His Gly Arg Cys Gly Ile Pro Glu Ala
1110                1115                1120                1125

 ctg gtg cag aga tac gca gag gac ttg gat cag ccc gag cgg gac gtc     4003
 Leu Val Gln Arg Tyr Ala Glu Asp Leu Asp Gln Pro Glu Arg Asp Val
                1130                1135                1140

 gcc gcc aac atg gac cag atc cgg gtg aag cag ctt cgg aag cag cac     4051
 Ala Ala Asn Met Asp Gln Ile Arg Val Lys Gln Leu Arg Lys Gln His
            1145                1150                1155

 cgc atg gcg att cca agt ggt gga ctc acg gaa atc tgc cga aag ccc     4099
 Arg Met Ala Ile Pro Ser Gly Gly Leu Thr Glu Ile Cys Arg Lys Pro
        1160                1165                1170

 gtc tct cct ggg tgc att tcg tct gtg tca gat tgg ctc att tcc atc     4147
 Val Ser Pro Gly Cys Ile Ser Ser Val Ser Asp Trp Leu Ile Ser Ile
    1175                1180                1185

 ggt ctg ccc atg tac gcc ggc acc ctc tcc acc gcg ggc ttc agc aca     4195
 Gly Leu Pro Met Tyr Ala Gly Thr Leu Ser Thr Ala Gly Phe Ser Thr
1190                1195                1200                1205

 ctg agc caa gtg cct tct ctg tct cac act tgc ctt cag gag gcc ggc     4243
 Leu Ser Gln Val Pro Ser Leu Ser His Thr Cys Leu Gln Glu Ala Gly
                1210                1215                1220

 atc aca gag gag aga cac ata aga aag ctc cta tct gca gcc aga ctc     4291
 Ile Thr Glu Glu Arg His Ile Arg Lys Leu Leu Ser Ala Ala Arg Leu
            1225                1230                1235

 ttc aaa ctg ccg cca ggc cct gag gcc atg t agccaggccc ggaatgggcc     4342
 Phe Lys Leu Pro Pro Gly Pro Glu Ala Met 
        1240                1245

 tctctggaca agagccaccc tttcactgtg catatgatgc tgatgcaatt cctccatcat   4402

 ctctggacgt gcagaccaga tccagaagaa aggcctggcg tgtggccaaa cagcgtgaaa   4462

 ccttggcaca ggactgagga tcctctcctc cagaaaagcc ccctcgagga aataaattag   4522

 tgcggttctc tttgacctcc aaagacaaga caagcactta tttttatttt cagaagacaa   4582

 aagaaccaag atgccaactg gctgcgaatg ctctatctcc agtctgtctc tgtgtactgg   4642

 tagaggctgg gaggagtagg gggcagcctg ttccatttct gatagtgccc ttgctcttct   4702

 gtctgtcatc ttgcaggatg cccgagggcc agatgggctt agctaggcca aagtaacaga   4762

 ctcaagagtt attgtacatt actgaccacg ctcatttgtt caaaagttag aacatctggc   4822

 tgcaccagga aaaaaaaaaa a                                             4843




      <210> 59
      <211> 2674
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(2599)

      <400> 59
 gcacgagctc tcctgtacct gggcatccag aaaa    atg gtg gtg atg gcg cga      52
                                          Met Val Val Met Ala Arg
                                            1               5

 ctt tcg cgg ccc gag cgg ccg gac ctt gtc ttc gag gaa gag gac ctc      100
 Leu Ser Arg Pro Glu Arg Pro Asp Leu Val Phe Glu Glu Glu Asp Leu
              10                  15                  20

 ccc tat gag gag gaa atc atg cgg aac caa ttc tct gtc aaa tgc tgg      148
 Pro Tyr Glu Glu Glu Ile Met Arg Asn Gln Phe Ser Val Lys Cys Trp
          25                  30                  35

 ctt cgc tac atc gag ttc aaa cag ggc gcc ccg aag ccc agg ctc aat      196
 Leu Arg Tyr Ile Glu Phe Lys Gln Gly Ala Pro Lys Pro Arg Leu Asn
      40                  45                  50

 cag cta tac gag cgg gca ctc aag ctg ctg ccc tgc agc tac aaa ctc      244
 Gln Leu Tyr Glu Arg Ala Leu Lys Leu Leu Pro Cys Ser Tyr Lys Leu
  55                  60                  65                  70

 tgg tac cga tac ctg aag gcg cgt cgg gca cag gtg aag cat cgc tgt      292
 Trp Tyr Arg Tyr Leu Lys Ala Arg Arg Ala Gln Val Lys His Arg Cys
                  75                  80                  85

 gtg acc gac cct gcc tat gaa gat gtc aac aac tgt cat gag agg gcc      340
 Val Thr Asp Pro Ala Tyr Glu Asp Val Asn Asn Cys His Glu Arg Ala
              90                  95                 100

 ttt gtg ttc atg cac aag atg cct cgt ctg tgg cta gat tac tgc cag      388
 Phe Val Phe Met His Lys Met Pro Arg Leu Trp Leu Asp Tyr Cys Gln
         105                 110                 115

 ttc ctc atg gac cag ggg cgc gtc aca cac acc cgc cgc acc ttc gac      436
 Phe Leu Met Asp Gln Gly Arg Val Thr His Thr Arg Arg Thr Phe Asp
     120                 125                 130

 cgt gcc ctc cgg gca ctg ccc atc acg cag cac tct cga att tgg ccc      484
 Arg Ala Leu Arg Ala Leu Pro Ile Thr Gln His Ser Arg Ile Trp Pro
 135                 140                 145                 150

 ctg tat ctg cgc ttc ctg cgc tca cac cca ctg cct gag aca gct gtg      532
 Leu Tyr Leu Arg Phe Leu Arg Ser His Pro Leu Pro Glu Thr Ala Val
                 155                 160                 165

 cga ggc tat cgg cgc ttc ctc aag ctg agt cct gag agt gca gag gag      580
 Arg Gly Tyr Arg Arg Phe Leu Lys Leu Ser Pro Glu Ser Ala Glu Glu
             170                 175                 180

 tac att gag tac ctc aag tca agt gac cgg ctg gat gag gcc gcc cag      628
 Tyr Ile Glu Tyr Leu Lys Ser Ser Asp Arg Leu Asp Glu Ala Ala Gln
         185                 190                 195

 cgc ctg gcc acc gtg gtg aac gac gag cgt ttc gtg tct aag gcc ggc      676
 Arg Leu Ala Thr Val Val Asn Asp Glu Arg Phe Val Ser Lys Ala Gly
     200                 205                 210

 aag tcc aac tac cag ctg tgg cac gag ctg tgc gac ctc atc tcc cag      724
 Lys Ser Asn Tyr Gln Leu Trp His Glu Leu Cys Asp Leu Ile Ser Gln
 215                 220                 225                 230

 aat ccg gac aag gta cag tcc ctc aat gtg gac gcc atc atc cgc ggg      772
 Asn Pro Asp Lys Val Gln Ser Leu Asn Val Asp Ala Ile Ile Arg Gly
                 235                 240                 245

 ggc ctc acc cgc ttc acc gac cag ctg ggc aag ctc tgg tgt tct ctc      820
 Gly Leu Thr Arg Phe Thr Asp Gln Leu Gly Lys Leu Trp Cys Ser Leu
             250                 255                 260

 gcc gac tac tac atc cgc agc ggc cat ttc gag aag gct cgg gac gtg      868
 Ala Asp Tyr Tyr Ile Arg Ser Gly His Phe Glu Lys Ala Arg Asp Val
         265                 270                 275

 tac gag gag gcc atc cgg aca gtg atg acc gtg cgg gac ttc aca cag      916
 Tyr Glu Glu Ala Ile Arg Thr Val Met Thr Val Arg Asp Phe Thr Gln
     280                 285                 290

 gtg ttt gac agc tac gcc cag ttc gag gag agc atg atc gct gca aag      964
 Val Phe Asp Ser Tyr Ala Gln Phe Glu Glu Ser Met Ile Ala Ala Lys
 295                 300                 305                 310

 atg gag acc gcc tcg gag ctg ggg cgc gag gag gag gat gat gtg gac     1012
 Met Glu Thr Ala Ser Glu Leu Gly Arg Glu Glu Glu Asp Asp Val Asp
                 315                 320                 325

 ctg gag ctg cgc ctg gcc cgc ttc gag cag ctc atc agc cgg cgg ccc     1060
 Leu Glu Leu Arg Leu Ala Arg Phe Glu Gln Leu Ile Ser Arg Arg Pro
             330                 335                 340

 ctg ctc ctc aac agc gtc ttg ctg cgc caa aac cca cac cac gtg cac     1108
 Leu Leu Leu Asn Ser Val Leu Leu Arg Gln Asn Pro His His Val His
         345                 350                 355

 gag tgg cac aag cgt gtc gcc ctg cac cag ggc cgc ccc cgg gag atc     1156
 Glu Trp His Lys Arg Val Ala Leu His Gln Gly Arg Pro Arg Glu Ile
     360                 365                 370

 atc aac acc tac aca gag gct gtg cag acg gtg gac ccc ttc aag gcc     1204
 Ile Asn Thr Tyr Thr Glu Ala Val Gln Thr Val Asp Pro Phe Lys Ala
 375                 380                 385                 390

 aca ggc aag ccc cac act ctg tgg gtg gcg ttt gcc aag ttt tat gag     1252
 Thr Gly Lys Pro His Thr Leu Trp Val Ala Phe Ala Lys Phe Tyr Glu
                 395                 400                 405

 gac aac gga cag ctg gac gat gcc cgt gtc atc ctg gag aag gcc acc     1300
 Asp Asn Gly Gln Leu Asp Asp Ala Arg Val Ile Leu Glu Lys Ala Thr
             410                 415                 420

 aag gtg aac ttc aag cag gtg gat gac ctg gca agc gtg tgg tgt cag     1348
 Lys Val Asn Phe Lys Gln Val Asp Asp Leu Ala Ser Val Trp Cys Gln
         425                 430                 435

 tgc gga gag ctg gag ctc cga cac gag aac tac gat gag gcc ttg cgg     1396
 Cys Gly Glu Leu Glu Leu Arg His Glu Asn Tyr Asp Glu Ala Leu Arg
     440                 445                 450

 ctg ctg cga aag gcc acg gcg ctg cct gcc cgc cgg gcc gag tac ttt     1444
 Leu Leu Arg Lys Ala Thr Ala Leu Pro Ala Arg Arg Ala Glu Tyr Phe
 455                 460                 465                 470

 gat ggt tca gag ccc gtg cag aac cgc gtg tac aag tca ctg aag gtc     1492
 Asp Gly Ser Glu Pro Val Gln Asn Arg Val Tyr Lys Ser Leu Lys Val
                 475                 480                 485

 tgg tcc atg ctc gcc gac ctg gag gag agc ctc ggc acc ttc cag tcc     1540
 Trp Ser Met Leu Ala Asp Leu Glu Glu Ser Leu Gly Thr Phe Gln Ser
             490                 495                 500

 acc aag gcc gtg tac gac cgc atc ctg gac ctg cgt atc gca aca ccc     1588
 Thr Lys Ala Val Tyr Asp Arg Ile Leu Asp Leu Arg Ile Ala Thr Pro
         505                 510                 515

 cag atc gtc atc aac tat gcc atg ttc ctg gag gag cac aag tac ttc     1636
 Gln Ile Val Ile Asn Tyr Ala Met Phe Leu Glu Glu His Lys Tyr Phe
     520                 525                 530

 gag gag agc ttc aag gcg tac gag cgc ggc atc tcg ctg ttc aag tgg     1684
 Glu Glu Ser Phe Lys Ala Tyr Glu Arg Gly Ile Ser Leu Phe Lys Trp
 535                 540                 545                 550

 ccc aac gtg tcc gac atc tgg agc acc tac ctg acc aaa ttc att gcc     1732
 Pro Asn Val Ser Asp Ile Trp Ser Thr Tyr Leu Thr Lys Phe Ile Ala
                 555                 560                 565

 cgc tat ggg ggc cgc aag ctg gag cgg gca cgg gac ctg ttt gaa cag     1780
 Arg Tyr Gly Gly Arg Lys Leu Glu Arg Ala Arg Asp Leu Phe Glu Gln
             570                 575                 580

 gct ctg gac ggc tgc ccc cca aaa tat gcc aag acc ttg tac ctg ctg     1828
 Ala Leu Asp Gly Cys Pro Pro Lys Tyr Ala Lys Thr Leu Tyr Leu Leu
         585                 590                 595

 tac gca cag ctg gag gag gag tgg ggc ctg gcc cgg cat gcc atg gcc     1876
 Tyr Ala Gln Leu Glu Glu Glu Trp Gly Leu Ala Arg His Ala Met Ala
     600                 605                 610

 gtg tac gag cgt gcc acc agg gcc gtg gag ccc gcc cag cag tat gac     1924
 Val Tyr Glu Arg Ala Thr Arg Ala Val Glu Pro Ala Gln Gln Tyr Asp
 615                 620                 625                 630

 atg ttc aac atc tac atc aag cgg gcg gcc gag atc tat ggg gtc acc     1972
 Met Phe Asn Ile Tyr Ile Lys Arg Ala Ala Glu Ile Tyr Gly Val Thr
                 635                 640                 645

 cac acc cgc ggc atc tac cag aag gcc att gag gtg ctg tcg gac gag     2020
 His Thr Arg Gly Ile Tyr Gln Lys Ala Ile Glu Val Leu Ser Asp Glu
             650                 655                 660

 cac gcg cgt gag atg tgc ctg cgg ttt gca gac atg gag tgc aag ctc     2068
 His Ala Arg Glu Met Cys Leu Arg Phe Ala Asp Met Glu Cys Lys Leu
         665                 670                 675

 ggg gag att gac cgc gcc cgg gcc atc tac agc ttc tgc tcc cag atc     2116
 Gly Glu Ile Asp Arg Ala Arg Ala Ile Tyr Ser Phe Cys Ser Gln Ile
     680                 685                 690

 tgt gac ccc cgg acg acc ggc gcg ttc tgg cag acg tgg aag gac ttt     2164
 Cys Asp Pro Arg Thr Thr Gly Ala Phe Trp Gln Thr Trp Lys Asp Phe
 695                 700                 705                 710

 gag gtc cgg cat ggc aat gag gac acc atc aag gaa atg ctg cgt atc     2212
 Glu Val Arg His Gly Asn Glu Asp Thr Ile Lys Glu Met Leu Arg Ile
                 715                 720                 725

 cgg cgc agc gtg cag gcc acg tac aac acg cag gtc aac ttc atg gcc     2260
 Arg Arg Ser Val Gln Ala Thr Tyr Asn Thr Gln Val Asn Phe Met Ala
             730                 735                 740

 tcg cag atg ctc aag gtc tcg ggc agt gcc acg ggc acc gtg tct gac     2308
 Ser Gln Met Leu Lys Val Ser Gly Ser Ala Thr Gly Thr Val Ser Asp
         745                 750                 755

 ctg gcc cct ggg cag agt ggc atg gac gac atg aag ctg ctg gaa cag     2356
 Leu Ala Pro Gly Gln Ser Gly Met Asp Asp Met Lys Leu Leu Glu Gln
     760                 765                 770

 cgg gca gag cag ctg gcg gct gag gcg gag cgt gac cag ccc ttg cgc     2404
 Arg Ala Glu Gln Leu Ala Ala Glu Ala Glu Arg Asp Gln Pro Leu Arg
 775                 780                 785                 790

 gcc cag agc aag atc ctg ttc gtg agg agt gac gcc tcc cgg gag gag     2452
 Ala Gln Ser Lys Ile Leu Phe Val Arg Ser Asp Ala Ser Arg Glu Glu
                 795                 800                 805

 ctg gca gag ctg gca cag cag gtc aac ccc gag gag atc cag ctg ggc     2500
 Leu Ala Glu Leu Ala Gln Gln Val Asn Pro Glu Glu Ile Gln Leu Gly
             810                 815                 820

 gag gac gag gac gag gac gag atg gac ctg gag ccc aac gag gtt cgg     2548
 Glu Asp Glu Asp Glu Asp Glu Met Asp Leu Glu Pro Asn Glu Val Arg
         825                 830                 835

 ctg gag cag cag agc gtg cca gcc gca gtg ttt ggg agc ctg aag gaa     2596
 Leu Glu Gln Gln Ser Val Pro Ala Ala Val Phe Gly Ser Leu Lys Glu
     840                 845                 850

 gac tgac ccgtccctcc cccatccccc ctccccaccc cctccccaat acagctacgt     2653
 Asp 
 855

 ttgtacatca aaaaaaaaaa a                                             2674




      <210> 60
      <211> 6768
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(2400)

      <400> 60
 agggcttgat gactataatg ggcccagttg tctgcgggct gcggggagct aagtccccag     60

 attggaggag gctggctctg gtcttcg    atg cac agg agt ggc cgt tat gga     111
                                  Met His Arg Ser Gly Arg Tyr Gly
                                    1               5

 acg cag cag cag cgt gca ggg tca aag aca gcc ggc ccc cca tgt cag      159
 Thr Gln Gln Gln Arg Ala Gly Ser Lys Thr Ala Gly Pro Pro Cys Gln
      10                  15                  20

 tgg tct agg atg gcc agt gaa ggc acc aac atc cca agt cct gtg gtg      207
 Trp Ser Arg Met Ala Ser Glu Gly Thr Asn Ile Pro Ser Pro Val Val
  25                  30                  35                  40

 cgc cag att gac aag cag ttt ctg att tgc agt ata tgc ctg gaa cgg      255
 Arg Gln Ile Asp Lys Gln Phe Leu Ile Cys Ser Ile Cys Leu Glu Arg
                  45                  50                  55

 tac aag aat ccc aag gtt ctc ccc tgt ctg cac act ttc tgc gag agg      303
 Tyr Lys Asn Pro Lys Val Leu Pro Cys Leu His Thr Phe Cys Glu Arg
              60                  65                  70

 tgc ctg cag aac tac att cct gcc cac agt tta acc ctc tcc tgc cca      351
 Cys Leu Gln Asn Tyr Ile Pro Ala His Ser Leu Thr Leu Ser Cys Pro
          75                  80                  85

 gtg tgc cgc cag acc tcc atc ctg ccc gag aaa ggg gtg gcc gcg ctc      399
 Val Cys Arg Gln Thr Ser Ile Leu Pro Glu Lys Gly Val Ala Ala Leu
      90                  95                 100

 cag aac aat ttc ttc atc aca aac ctg atg gac gtg ctg cag cga act      447
 Gln Asn Asn Phe Phe Ile Thr Asn Leu Met Asp Val Leu Gln Arg Thr
 105                 110                 115                 120

 cca ggc agc aac gct gag gag tct tcc atc ctg gag aca gtc act gct      495
 Pro Gly Ser Asn Ala Glu Glu Ser Ser Ile Leu Glu Thr Val Thr Ala
                 125                 130                 135

 gtg gct gcg gga aag cct ctc tct tgc cca aac cac gat ggg aat gtg      543
 Val Ala Ala Gly Lys Pro Leu Ser Cys Pro Asn His Asp Gly Asn Val
             140                 145                 150

 atg gaa ttt tac tgc cag tcc tgt gag act gcc atg tgt cgg gag tgc      591
 Met Glu Phe Tyr Cys Gln Ser Cys Glu Thr Ala Met Cys Arg Glu Cys
         155                 160                 165

 acg gag ggg gag cac gca gag cac ccc aca gtt cca ctc aag gat gtg      639
 Thr Glu Gly Glu His Ala Glu His Pro Thr Val Pro Leu Lys Asp Val
     170                 175                 180

 gtg gaa cag cac aag gcc tcg ctc cag gtc cag ctg gat gct gtc aac      687
 Val Glu Gln His Lys Ala Ser Leu Gln Val Gln Leu Asp Ala Val Asn
 185                 190                 195                 200

 aaa agg ctc cca gaa ata gat tct gct ctt cag ttc atc tct gaa atc      735
 Lys Arg Leu Pro Glu Ile Asp Ser Ala Leu Gln Phe Ile Ser Glu Ile
                 205                 210                 215

 att cat cag tta acc aac caa aag gcc agc atc gtg gat gac att cat      783
 Ile His Gln Leu Thr Asn Gln Lys Ala Ser Ile Val Asp Asp Ile His
             220                 225                 230

 tcc acc ttt gat gag ctc cag aag act tta aat gtg cgc aag agt gtg      831
 Ser Thr Phe Asp Glu Leu Gln Lys Thr Leu Asn Val Arg Lys Ser Val
         235                 240                 245

 ctg ctt atg gaa ttg gag gtc aac tat ggc ctc aaa cac aaa gtc ctc      879
 Leu Leu Met Glu Leu Glu Val Asn Tyr Gly Leu Lys His Lys Val Leu
     250                 255                 260

 cag tcg cag ctg gat act ctg ctc cag ggg cag gag agc att aag agc      927
 Gln Ser Gln Leu Asp Thr Leu Leu Gln Gly Gln Glu Ser Ile Lys Ser
 265                 270                 275                 280

 tgc agc aac ttc aca gcg cag gcc ctc aac cat ggc acg gag acc gag      975
 Cys Ser Asn Phe Thr Ala Gln Ala Leu Asn His Gly Thr Glu Thr Glu
                 285                 290                 295

 gtc cta ctg gtg aag aag cag atg agc gag aag ctg aac gag ctg gcc     1023
 Val Leu Leu Val Lys Lys Gln Met Ser Glu Lys Leu Asn Glu Leu Ala
             300                 305                 310

 gac cag gac ttc ccc ttg cac ccg cgg gag aac gac cag ctg gat ttc     1071
 Asp Gln Asp Phe Pro Leu His Pro Arg Glu Asn Asp Gln Leu Asp Phe
         315                 320                 325

 atc gtg gaa acc gag ggg ctg aag aag tcc atc cac aac ctc ggg acg     1119
 Ile Val Glu Thr Glu Gly Leu Lys Lys Ser Ile His Asn Leu Gly Thr
     330                 335                 340

 atc tta acc acc aac gcc gtt gcc tca gag aca gtg gcc acg ggc gag     1167
 Ile Leu Thr Thr Asn Ala Val Ala Ser Glu Thr Val Ala Thr Gly Glu
 345                 350                 355                 360

 ggg ctg cgg cag acc atc atc ggg cag ccc atg tcc gtc acc atc acc     1215
 Gly Leu Arg Gln Thr Ile Ile Gly Gln Pro Met Ser Val Thr Ile Thr
                 365                 370                 375

 acc aag gac aaa gac ggt gag ctg tgc aaa acc ggc aac gcc tac ctc     1263
 Thr Lys Asp Lys Asp Gly Glu Leu Cys Lys Thr Gly Asn Ala Tyr Leu
             380                 385                 390

 acc gcc gaa ctg agc acc ccc gac ggg agc gtg gca gac ggg gag atc     1311
 Thr Ala Glu Leu Ser Thr Pro Asp Gly Ser Val Ala Asp Gly Glu Ile
         395                 400                 405

 ctg gac aac aag aac ggc acc tat gag ttt ttg tac act gtc cag aag     1359
 Leu Asp Asn Lys Asn Gly Thr Tyr Glu Phe Leu Tyr Thr Val Gln Lys
     410                 415                 420

 gaa ggg gac ttt acc ctg tct ctg aga ctc tat gac cag cac atc cga     1407
 Glu Gly Asp Phe Thr Leu Ser Leu Arg Leu Tyr Asp Gln His Ile Arg
 425                 430                 435                 440

 ggc agc ccg ttt aag ctg aaa gtg atc cga tcc gct gat gtg tct ccc     1455
 Gly Ser Pro Phe Lys Leu Lys Val Ile Arg Ser Ala Asp Val Ser Pro
                 445                 450                 455

 acc aca gaa ggc gtg aag agg cgc gtt aag tcc ccg ggg agc ggc cac     1503
 Thr Thr Glu Gly Val Lys Arg Arg Val Lys Ser Pro Gly Ser Gly His
             460                 465                 470

 gtc aag cag aaa gct gtg aaa aga ccc gca agc atg tac agc act gga     1551
 Val Lys Gln Lys Ala Val Lys Arg Pro Ala Ser Met Tyr Ser Thr Gly
         475                 480                 485

 aaa cga aaa gag aat ccc atc gaa gac gat ttg atc ttt cga gtg ggt     1599
 Lys Arg Lys Glu Asn Pro Ile Glu Asp Asp Leu Ile Phe Arg Val Gly
     490                 495                 500

 acc aaa gga aga aat aaa gga gag ttt aca aat ctt cag ggg gta gct     1647
 Thr Lys Gly Arg Asn Lys Gly Glu Phe Thr Asn Leu Gln Gly Val Ala
 505                 510                 515                 520

 gca tct aca aat gga aag ata tta att gca gac agt aac aac caa tgt     1695
 Ala Ser Thr Asn Gly Lys Ile Leu Ile Ala Asp Ser Asn Asn Gln Cys
                 525                 530                 535

 gtg cag ata ttt tcc aat gat ggc cag ttc aaa agt cgt ttt ggc ata     1743
 Val Gln Ile Phe Ser Asn Asp Gly Gln Phe Lys Ser Arg Phe Gly Ile
             540                 545                 550

 cgg gga cgc tct ccg ggg cag ctg cag cgg ccc aca gga gtg gct gta     1791
 Arg Gly Arg Ser Pro Gly Gln Leu Gln Arg Pro Thr Gly Val Ala Val
         555                 560                 565

 cat ccc agt ggg gac ata atc att gcc gat tat gat aat aaa tgg gtc     1839
 His Pro Ser Gly Asp Ile Ile Ile Ala Asp Tyr Asp Asn Lys Trp Val
     570                 575                 580

 agc att ttc tcc tcc gat ggg aaa ttt aag aca aaa att gga tca gga     1887
 Ser Ile Phe Ser Ser Asp Gly Lys Phe Lys Thr Lys Ile Gly Ser Gly
 585                 590                 595                 600

 aag ctg atg gga ccc aaa gga gtt tct gtg gac cgc aat ggg cac att     1935
 Lys Leu Met Gly Pro Lys Gly Val Ser Val Asp Arg Asn Gly His Ile
                 605                 610                 615

 att gtt gtg gac aac aag gcg tgc tgc gtg ttt atc ttc cag cca aac     1983
 Ile Val Val Asp Asn Lys Ala Cys Cys Val Phe Ile Phe Gln Pro Asn
             620                 625                 630

 ggg aaa ata gtc acc agg ttt ggt agc cga gga aat ggg gac agg cag     2031
 Gly Lys Ile Val Thr Arg Phe Gly Ser Arg Gly Asn Gly Asp Arg Gln
         635                 640                 645

 ttt gca ggt ccc cat ttt gca gct gta aat agc aat aat gag att att     2079
 Phe Ala Gly Pro His Phe Ala Ala Val Asn Ser Asn Asn Glu Ile Ile
     650                 655                 660

 att aca gat ttc cat aat cat tct gtc aag gtg ttt aat cag gaa gga     2127
 Ile Thr Asp Phe His Asn His Ser Val Lys Val Phe Asn Gln Glu Gly
 665                 670                 675                 680

 gaa ttc atg ttg aag ttt ggc tca aat gga gaa gga aat ggg cag ttt     2175
 Glu Phe Met Leu Lys Phe Gly Ser Asn Gly Glu Gly Asn Gly Gln Phe
                 685                 690                 695

 aat gct cca aca ggt gta gca gtg gat tca aat gga aac atc att gtg     2223
 Asn Ala Pro Thr Gly Val Ala Val Asp Ser Asn Gly Asn Ile Ile Val
             700                 705                 710

 gcc gac tgg gga aac agc agg atc cag gtt ttt gat ggg agt gga tca     2271
 Ala Asp Trp Gly Asn Ser Arg Ile Gln Val Phe Asp Gly Ser Gly Ser
         715                 720                 725

 ttt ttg tcc tac att aac aca tct gct gac cca ctc tat ggc ccc caa     2319
 Phe Leu Ser Tyr Ile Asn Thr Ser Ala Asp Pro Leu Tyr Gly Pro Gln
     730                 735                 740

 ggc ctg gcc cta act tca gat ggt cat gtt gtg gtt gca gac tct gga     2367
 Gly Leu Ala Leu Thr Ser Asp Gly His Val Val Val Ala Asp Ser Gly
 745                 750                 755                 760

 aat cac tgt ttc aaa gtc tat cga tac tta cag taatggtg ggcaggtgga     2418
 Asn His Cys Phe Lys Val Tyr Arg Tyr Leu Gln 
                 765                 770

 tacccgcttc catggtcttg cactataaac tggaatggat ttctcaatgc gggaccagat   2478

 tatgactaga gtttttatgc cagaaggaat cattggtgaa ctttccaagg ttatttctga   2538

 atgtaacaat ttccttaaaa atgacttatc caatttctgt atttcacctt tagggttaaa   2598

 aaaaactctt ctactgaatc tataaaaact gcagttttac atctgtgaac tatggcttaa   2658

 gggacaggat ttatgtagct aaactaattt tgcaaatcaa acagacactt aaaaaactag   2718

 catatgtaaa ggtattcgtt aatcctgtga atggtagctt ttgcacagaa cttccaaaag   2778

 caaaacaaaa acaaaatcta ttgtagttat atacttcatt taacctaggt cacaagaccc   2838

 agggaatctt ctaacctcac ttttacagta ggtattactc ttgtgacatt tttttggtta   2898

 tcaacaacta aatataaatt actttggaaa aagtaaggct gtcttgcaaa atgatcccag   2958

 ctctgattag cagccctctg gagttcagaa cttaagtatc agtgcaaatt tctcaacctt   3018

 tctgggttag acaaagatcc ttttttgtgt gttcttttca ccaccccttt ggctcacctt   3078

 gtatcagcaa acaaagtact tcttcaggga aacctgaaat ttctaatgcc ttgaaaagca   3138

 tattacaaaa gtaatgctac cttttgggaa acaaactgcc ccgttaactc cagatcattg   3198

 cactggaatg taatcaagaa agttagtcat gttttatgta ccatgttttc acacgtgtct   3258

 cttctcttcg acttcctgaa agcgaaagct ttacctcctg caaatgtcag cacatgtagt   3318

 aggacaccag tatcctagga cagagagcca taagtagccc tttggaggac tgatggtgtc   3378

 aaccaaaggc atgtgattga ttaatgattc ccccttagaa agcaagtgtt accaaagttg   3438

 tgttatcttg aaagcattac aggtaagggc atgttatggt tatttatcat tgtttaatga   3498

 atagtagagg tgtcaaggga ctatgtatac atgattaggg taagatagaa tgtattatat   3558

 atatatatat atatacacac acacatatat atagctgaat ctttggtgta ttgaaatagg   3618

 cagcactctg aaagacagaa gcttcgtcca gccactcttc agcacattcc tttactaagc   3678

 agtttaaagc cgtcctagtg gagcaagccc taaagcagat ttaatttttg ccattttcca   3738

 agaatgacgg tggtggcttt tagtcagaaa atggccttct gtgctttcaa aaaaaaaaaa   3798

 aaaaaaaaaa ccacacacac acataaaaaa cccaacaggt caaaataaaa gttgaacttg   3858

 agttacattt aatttaaata taaatgcatt ttgagaaatg ttaagaacaa tttagtcaat   3918

 cgttcatctg tcattggtac tgtaaaataa gctgtggtct atttccactg tttaattttc   3978

 tactcagttc taccaaatag gatgtcatgt ttgacatttt tgatagtgac tttggggtct   4038

 tcttcactga aagcacctta gaactgtact ataagaaaac atttccccta tgtataatta   4098

 tatgaatgtg atgtttattg cttattaatt tataattcag tcattctcta tataggactt   4158

 cttaaaattt agaagggaaa tctagctact tcaaattgtc tgttaaattt attatgccca   4218

 aatcaacctc tgaaaaaagg tttttccagg aagatttaca tttaggttta atattttttt   4278

 agttaggtag agttttaaaa aatacttgag cctgtccgtg ataaagctat aaaattcaat   4338

 aactttttag aatgttaaat gaagacactg tttcctaaca tcagtgagat acatctttga   4398

 atttaaacat tcatatttac tgagtaccta ctaggtacca agtactcttt taggcactgg   4458

 aaatacagtg atggacaaaa caggtaaaaa atcgctgccc cctcagagct gacattctgg   4518

 ggtgggaatt tcattttgcc acgtactaac gttctgcaca aaagacaggc tagactcttg   4578

 tctagattgt ttaaaagaaa cttttcaaat tggttacatt aattttagtt tattttcaca   4638

 agtaaaaatg gctttttatt tagattcttt ctgtcccagg ctgttgatct taaaactagt   4698

 tgatttaaag agtttttttg cacaacattt caattatatt tgtgaactta gaaattaact   4758

 tacaatctaa ccagccatca tatcatatcc tatcaggcta gatatctcaa tagtagactg   4818

 aatacaaagc taattttttt tacatgtcaa tattggcaca aactggaatg aaagaatagt   4878

 ttgattcaga cctgctccac tatgtgttgc taaaacacat gctatgagca ctccaggaaa   4938

 cactatattt tttccaaaaa atatgtgatt atatatgtta aagtatagat aacatttcac   4998

 acttggatac atatgtgcat ttactgtatt tcttggtaag catatttttg ggggaaagtg   5058

 ctgctgatat gatacaagta gacaaaattt aaatgaaatt ttgtcacatt ctatggaaaa   5118

 tggtttctgg taaactgaga aggatattaa aataagtggc ttttttctgg gctaccatta   5178

 ttgtttgatt tctctttgtc aagtgtatag aacctgtcat acattcatga taagtagcac   5238

 tgaaaaatta ctcattcaaa tttcccctgg gcacgtaagg caaaatattg ccggttggga   5298

 tttcaaggtc agtgacgacg catttcctcc cagtacagac cccccagccc cccttgctgg   5358

 acatggggag gcagagagtc acttgaccat ccagaaatac atgactacaa gtcctttatg   5418

 actgtttgcc atttttttta atggtactta gtattttgat caaactttag tctccagaac   5478

 taaacaagtc cctaagtttc cttattttaa tttactgtga ctagatttga agcaaataaa   5538

 tactccagat ccatgcagct agaacacact tgcttccact actaaatata cagggtatgt   5598

 cctaacatgg agttaactgg aatagcagta cactagcaag tatctgtgaa tccttagcac   5658

 tgacgggtta acagaaatgc tttggtaata cctacttagt taattggagg aagtagtaaa   5718

 taaacattag gtaatctgca gattacttca aatgggaaaa atctttttgt agactctata   5778

 gtaccctctc tattcactag cttctgaaaa gggaggagta tttttagttt gacaatttaa   5838

 taatttaaaa acaagacatc tccaggtagg aaaaaatgaa agctatttca tgcaaacatt   5898

 atctaattta gcttaaaagt gaaagtggta atactgttgg tttctgtaaa tgttgcaggg   5958

 ttttaaactt tataattact ttaatatttt tgataactag aaatctagta ttgccataaa   6018

 ggaaactaag tgcccatcaa agatttgttt ggtataaata aagaattatt tgttttgttt   6078

 tcaatgacag taagctacaa atcatgatgc ttaaaaactt tctaaagatg aattgtgtgg   6138

 cagtgattgg tctgtttgtg gagaatgtat gaaagctatt aatattctag aatagattaa   6198

 taaattggct atgttgttcc aatgaatgta cagcacttcc attaactttt gaaagcaaca   6258

 cagccttaaa ctcaatgctt ttgctttatg acatgggaat gttctgtcat caatggagtg   6318

 tattcttgta atagaattct ttatatcgtt ctcaattcta tagactttca agcctatgta   6378

 tgaatatgaa ggggtttttt tttttttgct ttgttttctt tttagatttt gtacattcca   6438

 tctttatagg tctgtttcat atgttttatg tatagaacac taagtcttgc actctctgac   6498

 attgatactg atatattctc gtcatttgtt cttttatgaa tcaaaatgtt gactgcctat   6558

 ttaaagaaaa gaatgaacgc tgtgcatcaa agtgtttgta tgttcgtagc tacatacgta   6618

 ccacagtatt ttggatgctt tagtctacaa tgaaactttc aattaattct gtcttgaaac   6678

 ataggagaaa caggattcat gtgtatctct ttaccatgca caaaatctca aatcattata   6738

 ataaagcttg ttttctccaa aaaaaaaaaa                                    6768




      <210> 61
      <211> 1611
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (646)..(813)

      <400> 61
 tcgcgatcta gaacccccca tactccttac actattcctc atcacccaac taaaaatatt     60

 aaacacaaac taccacctac ctccctcacc aaagcccata aaaataaaaa attataacaa    120

 accctgagaa ccaaaatgaa cgaaaatctg ttcgcttcat tcattgcccc cacaatccta    180

 ggcctacccg ccgcagtact gatcattcta tttccccctc tattgatccc cacctccaaa    240

 tatctcatca acaaccgact aatcaccacc caacaatgac taatcaaact aacctcaaaa    300

 caaataataa ccatacacaa cactaaagga cgaacctgat ctcttatact agtatcctta    360

 atcattttta ttgccacaac taacctcctc ggactcctgc ctcactcatt tacaccaacc    420

 acccaactat ctataaacct agccatggcc atccccttat gagcgggcgc agtgattata    480

 ggctttcgct ctaagattaa aaatgcccta gcccacttct taccacaagg cacacctaca    540

 ccccttatcc ccatactagt tattatcgaa accatcagcc tactcattca accaatagcc    600

 ctggccgtac gcctaaccgc taacattact gcaggccacc tactc    atg cac cta     654
                                                      Met His Leu
                                                        1

 att gga agc gcc acc cta gca ata tca acc att aac ctt ccc tct aca      702
 Ile Gly Ser Ala Thr Leu Ala Ile Ser Thr Ile Asn Leu Pro Ser Thr
       5                  10                  15

 ctt atc atc ttc aca att cta att cta ctg act atc cta gaa atc gct      750
 Leu Ile Ile Phe Thr Ile Leu Ile Leu Leu Thr Ile Leu Glu Ile Ala
  20                  25                  30                  35

 gtc gcc tta atc caa gcc tac gtt ttc aca ctt cta gta agc ctc tac      798
 Val Ala Leu Ile Gln Ala Tyr Val Phe Thr Leu Leu Val Ser Leu Tyr
                  40                  45                  50

 ctg cac gac aac aca taatgaccca ccaatcacat gcctatcata tagtaaaacc      853
 Leu His Asp Asn Thr 
              55

 cagcccatga cccctaacag gggccctctc agccctccta atgacctccg gcctagccat    913

 gtgatttcac ttccactcca taacgctcct catactaggc ctactaacca acacactaac    973

 catataccaa tgatggcgcg atgtaacacg agaaagcaca taccaaggcc accacacacc   1033

 acctgtccaa aaaggccttc gatacgggat aatcctattt attacctcag aagttttttt   1093

 cttcgcagga tttttctgag ccttttacca ctccagccta gcccctaccc cccaattagg   1153

 agggcactgg cccccaacag gcatcacccc gctaaatccc ctagaagtcc cactcctaaa   1213

 cacatccgta ttactcgcat caggagtatc aatcacctga gctcaccata gtctaataga   1273

 aaacaaccga aaccaaataa ttcaagcact gcttattaca attttactgg gtctctattt   1333

 taccctccta caagcctcag agtacttcga gtctcccttc accatttccg acggcatcta   1393

 cggctcaaca ttttttgtag ccacaggctt ccacggactt cacgtcatta ttggctcaac   1453

 tttcctcact atctgcttca tccgccaact aatatttcac tttacatcca aacatcactt   1513

 tggcttcgaa gccgccgcct gatactggca ttttgtagat gtggtttgac tatttctgta   1573

 tgtctccatc tattgatgag ggtcttaaaa aaaaaaaa                           1611




      <210> 62
      <211> 2780
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(2502)

      <400> 62
 cgcggctgga ggtgtgagga tccgaaccca ggggtggggg gtggaggcgg ctcctgcgat     60

 cgaaggggac ttgagactca ccggccgcac gcc atg agg gcc ctg tgg gtg ctg     114
                                      Met Arg Ala Leu Trp Val Leu
                                        1               5

 ggc ctc tgc tgc gtc ctg ctg acc ttc ggg tcg gtc aga gct gac gat      162
 Gly Leu Cys Cys Val Leu Leu Thr Phe Gly Ser Val Arg Ala Asp Asp
          10                  15                  20

 gaa gtt gat gtg gat ggt aca gta gaa gag gat ctg ggt aaa agt aga      210
 Glu Val Asp Val Asp Gly Thr Val Glu Glu Asp Leu Gly Lys Ser Arg
      25                  30                  35

 gaa gga tca agg acg gat gat gaa gta gta cag aga gag gaa gaa gct      258
 Glu Gly Ser Arg Thr Asp Asp Glu Val Val Gln Arg Glu Glu Glu Ala
  40                  45                  50                  55

 att cag ttg gat gga tta aat gca tca caa ata aga gaa ctt aga gag      306
 Ile Gln Leu Asp Gly Leu Asn Ala Ser Gln Ile Arg Glu Leu Arg Glu
                  60                  65                  70

 aag tcg gaa aag ttt gcc ttc caa gcc gaa gtt aac aga atg atg aaa      354
 Lys Ser Glu Lys Phe Ala Phe Gln Ala Glu Val Asn Arg Met Met Lys
              75                  80                  85

 ctt atc atc aat tca ttg tat aaa aat aaa gag att ttc ctg aga gaa      402
 Leu Ile Ile Asn Ser Leu Tyr Lys Asn Lys Glu Ile Phe Leu Arg Glu
          90                  95                 100

 ctg att tca aat gct tct gat gct tta gat aag ata agg cta ata tca      450
 Leu Ile Ser Asn Ala Ser Asp Ala Leu Asp Lys Ile Arg Leu Ile Ser
     105                 110                 115

 ctg act gat gaa aat gct ctt tct gga aat gag gaa cta aca gtc aaa      498
 Leu Thr Asp Glu Asn Ala Leu Ser Gly Asn Glu Glu Leu Thr Val Lys
 120                 125                 130                 135

 att aag tgt gat aag gag aag aac ctg ctg cat gtc aca gac acc ggt      546
 Ile Lys Cys Asp Lys Glu Lys Asn Leu Leu His Val Thr Asp Thr Gly
                 140                 145                 150

 gta gga atg acc aga gaa gag ttg gtt aaa aac ctt ggt acc ata gcc      594
 Val Gly Met Thr Arg Glu Glu Leu Val Lys Asn Leu Gly Thr Ile Ala
             155                 160                 165

 aaa tct ggg aca agc gag ttt tta aac aaa atg act gaa gca cag gaa      642
 Lys Ser Gly Thr Ser Glu Phe Leu Asn Lys Met Thr Glu Ala Gln Glu
         170                 175                 180

 gat ggc cag tca act tct gaa ttg att ggc cag ttt ggt gtc ggt ttc      690
 Asp Gly Gln Ser Thr Ser Glu Leu Ile Gly Gln Phe Gly Val Gly Phe
     185                 190                 195

 tat tcc gcc ttc ctt gta gca gat aag gtt att gtc act tca aaa cac      738
 Tyr Ser Ala Phe Leu Val Ala Asp Lys Val Ile Val Thr Ser Lys His
 200                 205                 210                 215

 aac aac gat acc cag cac atc tgg gag tct gac tcc aat gaa ttt tct      786
 Asn Asn Asp Thr Gln His Ile Trp Glu Ser Asp Ser Asn Glu Phe Ser
                 220                 225                 230

 gta att gct gac cca aga gga aac act cta gga cgg gga acg aca att      834
 Val Ile Ala Asp Pro Arg Gly Asn Thr Leu Gly Arg Gly Thr Thr Ile
             235                 240                 245

 acc ctt gtc tta aaa gaa gaa gca tct gat tac ctt gaa ttg gat aca      882
 Thr Leu Val Leu Lys Glu Glu Ala Ser Asp Tyr Leu Glu Leu Asp Thr
         250                 255                 260

 att aaa aat ctc gtc aaa aaa tat tca cag ttc ata aac ttt cct att      930
 Ile Lys Asn Leu Val Lys Lys Tyr Ser Gln Phe Ile Asn Phe Pro Ile
     265                 270                 275

 tat gta tgg agc agc aag act gaa act gtt gag gag ccc atg gag gaa      978
 Tyr Val Trp Ser Ser Lys Thr Glu Thr Val Glu Glu Pro Met Glu Glu
 280                 285                 290                 295

 gaa gaa gca gcc aaa gaa gag aaa gaa gaa tct gat gat gaa gct gca     1026
 Glu Glu Ala Ala Lys Glu Glu Lys Glu Glu Ser Asp Asp Glu Ala Ala
                 300                 305                 310

 gta gag gaa gaa gaa gaa gaa aag aaa cca aag act aaa aaa gtt gaa     1074
 Val Glu Glu Glu Glu Glu Glu Lys Lys Pro Lys Thr Lys Lys Val Glu
             315                 320                 325

 aaa act gtc tgg gac tgg gaa ctt atg aat gat atc aaa cca ata tgg     1122
 Lys Thr Val Trp Asp Trp Glu Leu Met Asn Asp Ile Lys Pro Ile Trp
         330                 335                 340

 cag aga cca tca aaa gaa gta gaa gaa gat gaa tac aaa gct ttc tac     1170
 Gln Arg Pro Ser Lys Glu Val Glu Glu Asp Glu Tyr Lys Ala Phe Tyr
     345                 350                 355

 aaa tca ttt tca aag gaa agt gat gac ccc atg gct tat att cac ttt     1218
 Lys Ser Phe Ser Lys Glu Ser Asp Asp Pro Met Ala Tyr Ile His Phe
 360                 365                 370                 375

 act gct gaa ggg gaa gtt acc ttc aaa tca att tta ttt gta ccc aca     1266
 Thr Ala Glu Gly Glu Val Thr Phe Lys Ser Ile Leu Phe Val Pro Thr
                 380                 385                 390

 tct gct cca cgt ggt ctg ttt gac gaa tat gga tct aaa aag agc gat     1314
 Ser Ala Pro Arg Gly Leu Phe Asp Glu Tyr Gly Ser Lys Lys Ser Asp
             395                 400                 405

 tac att aag ctc tat gtg cgc cgt gta ttc atc aca gac gac ttc cat     1362
 Tyr Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Thr Asp Asp Phe His
         410                 415                 420

 gat atg atg cct aaa tac ctc aat ttt gtc aag ggt gtg gtg gac tca     1410
 Asp Met Met Pro Lys Tyr Leu Asn Phe Val Lys Gly Val Val Asp Ser
     425                 430                 435

 gat gat ctc ccc ttg aat gtt tcc cgc gag act ctt cag caa cat aaa     1458
 Asp Asp Leu Pro Leu Asn Val Ser Arg Glu Thr Leu Gln Gln His Lys
 440                 445                 450                 455

 ctg ctt aag gtg att agg aag aag ctt gtt cgt aaa acg ctg gac atg     1506
 Leu Leu Lys Val Ile Arg Lys Lys Leu Val Arg Lys Thr Leu Asp Met
                 460                 465                 470

 atc aag aag att gct gat gat aaa tac aat gat act ttt tgg aaa gaa     1554
 Ile Lys Lys Ile Ala Asp Asp Lys Tyr Asn Asp Thr Phe Trp Lys Glu
             475                 480                 485

 ttt ggt acc aac atc aag ctt ggt gtg att gaa gac cac tcg aat cga     1602
 Phe Gly Thr Asn Ile Lys Leu Gly Val Ile Glu Asp His Ser Asn Arg
         490                 495                 500

 aca cgt ctt gct aaa ctt ctt agg ttc cag tct tct cat cat cca act     1650
 Thr Arg Leu Ala Lys Leu Leu Arg Phe Gln Ser Ser His His Pro Thr
     505                 510                 515

 gac att act agc cta gac cag tat gtg gaa aga atg aag gaa aaa caa     1698
 Asp Ile Thr Ser Leu Asp Gln Tyr Val Glu Arg Met Lys Glu Lys Gln
 520                 525                 530                 535

 gac aaa atc tac ttc atg gct ggg tcc agc aga aaa gag gct gaa tct     1746
 Asp Lys Ile Tyr Phe Met Ala Gly Ser Ser Arg Lys Glu Ala Glu Ser
                 540                 545                 550

 tct cca ttt gtt gag cga ctt ctg aaa aag ggc tat gaa gtt att tac     1794
 Ser Pro Phe Val Glu Arg Leu Leu Lys Lys Gly Tyr Glu Val Ile Tyr
             555                 560                 565

 ctc aca gaa cct gtg gat gaa tac tgt att cag gcc ctt ccc gaa ttt     1842
 Leu Thr Glu Pro Val Asp Glu Tyr Cys Ile Gln Ala Leu Pro Glu Phe
         570                 575                 580

 gat ggg aag agg ttc cag aat gtt gcc aag gaa gga gtg aag ttc gat     1890
 Asp Gly Lys Arg Phe Gln Asn Val Ala Lys Glu Gly Val Lys Phe Asp
     585                 590                 595

 gaa agt gag aaa act aag gag agt cgt gaa gca gtt gag aaa gaa ttt     1938
 Glu Ser Glu Lys Thr Lys Glu Ser Arg Glu Ala Val Glu Lys Glu Phe
 600                 605                 610                 615

 gag cct ctg ctg aat tgg atg aaa gat aaa gcc ctt aag gac aag att     1986
 Glu Pro Leu Leu Asn Trp Met Lys Asp Lys Ala Leu Lys Asp Lys Ile
                 620                 625                 630

 gaa aag gct gtg gtg tct cag cgc ctg aca gaa tct ccg tgt gct ttg     2034
 Glu Lys Ala Val Val Ser Gln Arg Leu Thr Glu Ser Pro Cys Ala Leu
             635                 640                 645

 gtg gcc agc cag tac gga tgg tct ggc aac atg gag aga atc atg aaa     2082
 Val Ala Ser Gln Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys
         650                 655                 660

 gca caa gcg tac caa acg ggc aag gac atc tct aca aat tac tat gcg     2130
 Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr Ala
     665                 670                 675

 agt cag aag aaa aca ttt gaa att aat ccc aga cac ccg ctg atc aga     2178
 Ser Gln Lys Lys Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile Arg
 680                 685                 690                 695

 gac atg ctt cga cga att aag gaa gat gaa gat gat aaa aca gtt ttg     2226
 Asp Met Leu Arg Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val Leu
                 700                 705                 710

 gat ctt gct gtg gtt ttg ttt gaa aca gca acg ctt cgg tca ggg tat     2274
 Asp Leu Ala Val Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly Tyr
             715                 720                 725

 ctt tta cca gac act aaa gca tat gga gat aga ata gaa aga atg ctt     2322
 Leu Leu Pro Asp Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met Leu
         730                 735                 740

 cgc ctc agt ttg aac att gac cct gat gca aag gtg gaa gaa gag ccc     2370
 Arg Leu Ser Leu Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu Pro
     745                 750                 755

 gaa gaa gaa cct gaa gag aca gca gaa gac aca aca gaa gac aca gag     2418
 Glu Glu Glu Pro Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr Glu
 760                 765                 770                 775

 caa gac gaa gat gaa gaa atg gat gtg gga aca gat gaa gaa gaa gaa     2466
 Gln Asp Glu Asp Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu Glu
                 780                 785                 790

 aca gca aag gaa tct aca gct gaa aaa gat gaa ttg taaa ttatactctc     2516
 Thr Ala Lys Glu Ser Thr Ala Glu Lys Asp Glu Leu 
             795                 800

 accatttgga tcctgtgtgg agagggaatg tgaaatttac atcatttctt tttgggagag   2576

 acttgttttg gatgccccct aatccccttc tcccctgcac tgtaaaatgt gggattatgg   2636

 gtcacaggaa aaagtgggtt ttttagttga atttttttta acattcctca tgaatgtaaa   2696

 tttgtactat ttaactgact attcttgatg taaaatcttg tcatgtgtat aaaaataaaa   2756

 aagatcccaa ataaaaaaaa aaaa                                          2780




      <210> 63
      <211> 682
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(306)

      <220>
      <221> misc_feature
      <222> (1)...(682)
      <223> n = a,t,c or g

      <400> 63
 cgaacgagtc aaccggatcg gtgactgtgg agggcgagct gagccctggc cgccgccaca     60
                                                                 
 atg ggc cgc gag ttt ggg aat ctg acg cgg atg cgg cat gtg atc agc      108
 Met Gly Arg Glu Phe Gly Asn Leu Thr Arg Met Arg His Val Ile Ser
   1               5                  10                  15

 tac agc ttg tca ccg ttc gag cag cgc gcc tat ccg cac gtc ttc act      156
 Tyr Ser Leu Ser Pro Phe Glu Gln Arg Ala Tyr Pro His Val Phe Thr
              20                  25                  30

 aaa gga atc ccc aat gtt ctg cgc cgc att cgg gag tct ttc ttt cgc      204
 Lys Gly Ile Pro Asn Val Leu Arg Arg Ile Arg Glu Ser Phe Phe Arg
          35                  40                  45

 gtg gtg ccg cag ttt gta gtg ttt tat ctt atc tac aca tgg ggg act      252
 Val Val Pro Gln Phe Val Val Phe Tyr Leu Ile Tyr Thr Trp Gly Thr
      50                  55                  60

 gaa gag ttc gag aga tcc aag agg aag aat cca gct gcc tat gaa aat      300
 Glu Glu Phe Glu Arg Ser Lys Arg Lys Asn Pro Ala Ala Tyr Glu Asn
  65                  70                  75                  80

 gac aaa tgagcaacgc atccggatga cggttccctg tctctgaaag acctttctct       356
 Asp Lys 


 gaaagaggag tctgcattgt agtgtctcaa agacacaata aacttcctat ggtctgcact    416

 gttgtgatat tacatttttg tgagtagaat cctgtgtgac cactaatatt caagttcatg    476

 aagcgcccct cctcagcatg agtcttgaag ttttgcctgg tctcgggttt tggtgaaaga    536

 gcagggctcc ccctttgttc cattatctac aagaaagtag ctgcaggtac tcctgcatct    596

 aaccatttgt gggtgacatg ggctatggcg agtgctggtt cttggccctc tgctcccata    656

 gcaacaataa agttcaccgg cnanan                                         682




      <210> 64
      <211> 464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (143)..(412)

      <400> 64
 catctgtgca cgagtggagg aagaaacggg aaatacctac ccactgtgca ggggcaaaaa     60

 cattctatat gcctgtgaca aaccagagtt tgttccaccc ccccatttaa agggcaagac    120

 aaccacaggc ctctacatca aa atg acg gtc caa tgg ggt gtc cag caa gcc     172
                          Met Thr Val Gln Trp Gly Val Gln Gln Ala
                            1               5                  10

 cca tcg ccc ttc caa agc cca ctc cac tca gag aca gtc atc agt cat      220
 Pro Ser Pro Phe Gln Ser Pro Leu His Ser Glu Thr Val Ile Ser His
                  15                  20                  25

 gcc aga ggc ccc aac atc ctc cca aat gat gat aaa aat cac act ctt      268
 Ala Arg Gly Pro Asn Ile Leu Pro Asn Asp Asp Lys Asn His Thr Leu
              30                  35                  40

 gga acc aca aat tgt ggt cag gca tgg tgg ctt atg tac gta atc cca      316
 Gly Thr Thr Asn Cys Gly Gln Ala Trp Trp Leu Met Tyr Val Ile Pro
          45                  50                  55

 aaa att tgg gag gcc aag gaa gga aaa tca ctt gag gcc agg agc tca      364
 Lys Ile Trp Glu Ala Lys Glu Gly Lys Ser Leu Glu Ala Arg Ser Ser
      60                  65                  70

 gga cca gcc tgg gca aca aag caa gac ccc atc tct aca atc aat caa      412
 Gly Pro Ala Trp Ala Thr Lys Gln Asp Pro Ile Ser Thr Ile Asn Gln 
  75                  80                  85                  90

 taaaattttt ttaaaaagac ttgcaaattg ccatggcagg tgtggtgctg cc            464




      <210> 65
      <211> 1420
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (98)..(958)

      <400> 65
 gagagcctga tgtctcccac agcctgctaa agcgagcagt cctcagggtt ttgatgtgga     60

 tcgagatgcc aaaaagctga acaaagcctg caaagga atg ggg acc aat gaa gca     115
                                          Met Gly Thr Asn Glu Ala
                                            1               5

 gcc atc att gaa atc tta tcg ggc agg aca tca gat gag agg caa caa      163
 Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu Arg Gln Gln
              10                  15                  20

 atc aag caa aag tac aag gca acg tac ggc aag gag ctg gag gaa gta      211
 Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu Glu Glu Val
          25                  30                  35

 ctc aag agt gag ctg agt gga aac ttc gag aag aca gcg ttg gcc ctt      259
 Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala Leu Ala Leu
      40                  45                  50

 ctg gac cat ccc agc gag tac gcc gcc cgg cag ctg cag aag gct atg      307
 Leu Asp His Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln Lys Ala Met
  55                  60                  65                  70

 aag ggt ctg ggc aca gat gag tcc gtc ctc att gag ttc ctg tgc acg      355
 Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Phe Leu Cys Thr
                  75                  80                  85

 agg acc aat aag gaa atc atc gcc att aaa gag gcc tac caa agg cta      403
 Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr Gln Arg Leu
              90                  95                 100

 ttt gat agg agc ctc gaa tca gat gtc aaa ggt gat aca agt gga aac      451
 Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr Ser Gly Asn
         105                 110                 115

 cta aaa aaa atc ctg gtg tct ctg ctg cag gct aat cgc aat gaa gga      499
 Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg Asn Glu Gly
     120                 125                 130

 gat gac gtg gac aaa gat cta gct ggt cag gat gcc aaa gat ctg tat      547
 Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys Asp Leu Tyr
 135                 140                 145                 150

 gat gca ggg gaa ggc cgc tgg ggc act gat gag ctt gcg ttc aat gaa      595
 Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala Phe Asn Glu
                 155                 160                 165

 gtc ctg gcc aag agg agc tac aag cag tta cga gcc acc ttt caa gcc      643
 Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr Phe Gln Ala
             170                 175                 180

 tat caa att ctc att ggc aaa gac ata gaa gaa gcc att gaa gaa gaa      691
 Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile Glu Glu Glu
         185                 190                 195

 aca tca ggc gac ttg cag aag gcc tat tta act ctc gtg aga tgt gcc      739
 Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val Arg Cys Ala
     200                 205                 210

 cag gat tgt gag gac tat ttt gct gaa cgt ctg tac aag tcg atg aag      787
 Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys Ser Met Lys
 215                 220                 225                 230

 ggt gcg ggg acc gat gag gag acg ttg att cgc ata atc gtg acc agg      835
 Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Ile Val Thr Arg
                 235                 240                 245

 gcc gag gtg gac ctt cag ggg atc aaa gca aag ttc caa gag aag tat      883
 Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln Glu Lys Tyr
             250                 255                 260

 cag aag tct ctc tct gac atg gtt cgc tca gat acc tcc ggg gac ttc      931
 Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser Gly Asp Phe
         265                 270                 275

 cgg aaa ctg cta gta gcc ctc ttg cac tgagc caagccaggg caataggaac      983
 Arg Lys Leu Leu Val Ala Leu Leu His 
     280                 285

 acagggtgga accacctttg tcaagagcac attccaaatc aaacttgcaa atgagactcc   1043

 cgcacgaaaa cccttaagag tcccggatta ctttcttggc agcttaagtg gcgcagccag   1103

 gccaagctgt gtaagttaag ggcagtaacg ttaagatgcg tgggcagggc accttgaact   1163

 ctggcttagc aagcatctag gctgcctctt cactttcttt tagcatggta actggatgtt   1223

 ttctaaacac taatgaaatc agcagttgat gaaaaaacta tgcatttgta atggcacatt   1283

 tagaaggata tgcatcacac aagtaaggta caggaaagac aaaattaaac aatttattaa   1343

 ttttccttct gtgtgttcaa tttgaaagcc tcattgttaa ttaaagttgt ggattatgcc   1403

 tctaaaaaaa aaaaaaa                                                  1420




      <210> 66
      <211> 813
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(648)

      <400> 66
 tcgacccctc cgacccccgc cggccgcttc gagcctgagc cctttgcaac ttcgtcgttc     60

 cgccgctcca gcgtcgccac cgcgcctcgc cccgccgcca cc   atg acc acc gcg     114
                                                  Met Thr Thr Ala
                                                    1

 tct ccc tcg caa gtg cgc cag aac tac cac cag gac gcg gag gct gcc      162
 Ser Pro Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ala Glu Ala Ala
   5                  10                  15                  20

 atc aac cgc cag atc aac ctg gag ttg tat gcc tcc tac gtc tat ctg      210
 Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu
                  25                  30                  35

 tct atg tct tgt tat ttt gac cga gat gat gtg gct ctg aag aac ttt      258
 Ser Met Ser Cys Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe
              40                  45                  50

 gcc aaa tac ttt ctc cac caa tct cat gag gag agg gag cat gcc gag      306
 Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu
          55                  60                  65

 aaa ctg atg aag ctg cag aac cag cga ggt ggc cga atc ttc ctg cag      354
 Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln
      70                  75                  80

 gat ata aag aaa cca gac cgt gat gac tgg gag agc ggg ctg aat gca      402
 Asp Ile Lys Lys Pro Asp Arg Asp Asp Trp Glu Ser Gly Leu Asn Ala
  85                  90                  95                 100

 atg gag tgt gca ctg cac ttg gaa aag agt gtg aat cag tca cta ctg      450
 Met Glu Cys Ala Leu His Leu Glu Lys Ser Val Asn Gln Ser Leu Leu
                 105                 110                 115

 gaa ctg cac aaa ctg gct act gac aag aat gat ccc cac tta tgt gac      498
 Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Cys Asp
             120                 125                 130

 ttc att gag acg tat tat ctg agt gaa cag gtg aaa tcc att aaa gaa      546
 Phe Ile Glu Thr Tyr Tyr Leu Ser Glu Gln Val Lys Ser Ile Lys Glu
         135                 140                 145

 ctg ggt gac cac gtg acc aac tta cgc aag atg ggt gcc cct gaa gct      594
 Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ala
     150                 155                 160

 ggc atg gca gaa tat ctc ttt gac aag cac acc ctg gga cac ggt gat      642
 Gly Met Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly His Gly Asp
 165                 170                 175                 180

 gag agc taagctgact tccccaaagc cacgtgactt tactggtcac tgaggcagtg       698
 Glu Ser 


 catgcatgtc aggctgcctt catcttttct ataagttgca ccaaaacatc tgcttaagtt    758

 ctttaatttg taccatttct tcaaataaag aattttggta cccaaaaaaa aaaaa         813




      <210> 67
      <211> 810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(664)

      <400> 67
 actacagctc cgactgtcag tgccggcctt cctcgtgtga ggggatctgc cggacccctg     60

 caaattcaat ttctttccca ttccgggccc ttccctatcg tcgccccctt caccttggat    120

 c    atg ttc aag aaa ttt gat gaa aaa gaa aat gtg tcc aac tgc atc     166
      Met Phe Lys Lys Phe Asp Glu Lys Glu Asn Val Ser Asn Cys Ile
        1               5                  10                  15

 cag ttg aaa act tca gtt att aag ggt att aag aat caa ttg ata gag      214
 Gln Leu Lys Thr Ser Val Ile Lys Gly Ile Lys Asn Gln Leu Ile Glu
                  20                  25                  30

 caa ttt cca ggt att gaa cca tgg ctt aat caa atc atg cct aag aaa      262
 Gln Phe Pro Gly Ile Glu Pro Trp Leu Asn Gln Ile Met Pro Lys Lys
              35                  40                  45

 gat cct gtc aaa ata gtc cga tgc cat gaa cat ata gaa atc ctt aca      310
 Asp Pro Val Lys Ile Val Arg Cys His Glu His Ile Glu Ile Leu Thr
          50                  55                  60

 gta aat gga gaa tta ctc ttt ttt aga caa aga gaa ggg cct ttt tat      358
 Val Asn Gly Glu Leu Leu Phe Phe Arg Gln Arg Glu Gly Pro Phe Tyr
      65                  70                  75

 cca acc cta aga tta ctt cac aaa tat cct ttt atc ctg cca cac cag      406
 Pro Thr Leu Arg Leu Leu His Lys Tyr Pro Phe Ile Leu Pro His Gln
  80                  85                  90                  95

 cag gtt gat aaa gga gcc atc aaa ttt gta ctc agt gga gca aat atc      454
 Gln Val Asp Lys Gly Ala Ile Lys Phe Val Leu Ser Gly Ala Asn Ile
                 100                 105                 110

 atg tgt cca ggc tta act tct cct gga gct aag ctt tac cct gct gca      502
 Met Cys Pro Gly Leu Thr Ser Pro Gly Ala Lys Leu Tyr Pro Ala Ala
             115                 120                 125

 gta gat acc att gtt gct atc atg gca gaa gga aaa cag cat gct cta      550
 Val Asp Thr Ile Val Ala Ile Met Ala Glu Gly Lys Gln His Ala Leu
         130                 135                 140

 tgt gtt gga gtc atg aag atg tct gca gaa gac att gag aaa gtc aac      598
 Cys Val Gly Val Met Lys Met Ser Ala Glu Asp Ile Glu Lys Val Asn
     145                 150                 155

 aaa gga att ggc att gaa aat atc cat tat tta aat gat ggg ctg tgg      646
 Lys Gly Ile Gly Ile Glu Asn Ile His Tyr Leu Asn Asp Gly Leu Trp
 160                 165                 170                 175

 cat atg aag aca tat aaa tgagcc tcagaaggaa tgcacttggg ctaaatatgg      700
 His Met Lys Thr Tyr Lys 
                 180

 atattgtgct gtatctgtgt ttgtgtctgt gtgtgacagc atgaagataa tgcctgtggt    760

 tatgctgaat aaattcacca gatgctaaaa ttcaaaaaaa aaaaaaaaaa               810




      <210> 68
      <211> 745
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (483)..(572)

      <400> 68
 cttgagagct tctcattagc ctttgcctct gtacagaaac aggctaatga gaaaagggca     60

 ctccggaaaa agaggaaggc cctggagttt gtaactaatc ctgatattgc tgccaagaaa    120

 aaaatgaaga aacacaaaaa taaaagtgaa gcaaagaaga gaaagataga gttcctgcgt    180

 ccaggatata aggccaagag acaaaaaagc catagcctga aagatttagc aatggtggag    240

 taatgtctcc ctgtgctgat acaagcatga actttctgga atattctgct agtctgaaat    300

 tacagcaggt tgtctggggt aggggggagg cgtttttttt tttttttgag acaaggtctc    360

 actctgtcac ccaaggtgga gtgcagtgac gacatcacag ctcactgcag cctcaacctg    420

 ggttcaagtg atcctctcac ctcagcctcc caagtagttg tgcctcctag gcacacaaca    480

 ct   atg ccc ggc aaa ttt ttt gta ttt tgt att ttt tgt aga aac agg     527
      Met Pro Gly Lys Phe Phe Val Phe Cys Ile Phe Cys Arg Asn Arg
        1               5                  10                  15

 att tcg cca tgt tgg cca ggc tgg tct cga aca cct ggg ctc aac tga      575
 Ile Ser Pro Cys Trp Pro Gly Trp Ser Arg Thr Pro Gly Leu Asn 
                  20                  25                  30

 tccgcctgcc tcggcctccc aaagtgctgg gattacaggt gtgagccacc ctgctcaacc    635

 aggttttatt atttaagtta gttaaacttt ggatagattg tataatatat agtttaatgt    695

 aatcatgctc atatttttta aataaataaa acactatact aaaaaaaaaa               745




      <210> 69
      <211> 1554
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(1285)

      <400> 69
 cctgccgcac cagagcacag cgcactagtg ggacaggggt cctgactcag acttaactgg     60

 ctgtgtctcg tggtttttca ctgtcctgga aaaggcctga agtggcactg aaatgaggca    120

 tagatgagaa acttgaactt tacctgattt ctgt    atg ttg tca tct tgc gta     172
                                          Met Leu Ser Ser Cys Val
                                            1               5

 cgc cca gtc ccc acg aca gtc cgg ttt gta gat tcc ctg atc tgc aat      220
 Arg Pro Val Pro Thr Thr Val Arg Phe Val Asp Ser Leu Ile Cys Asn
              10                  15                  20

 tct tcc cgt tcc ttc atg gat ttg aag gct ctc ctt tct tcc ttg aat      268
 Ser Ser Arg Ser Phe Met Asp Leu Lys Ala Leu Leu Ser Ser Leu Asn
          25                  30                  35

 gac ttt gca tcc ctc tcg ttt gct gag agt tgg gac aat gtt gga tta      316
 Asp Phe Ala Ser Leu Ser Phe Ala Glu Ser Trp Asp Asn Val Gly Leu
      40                  45                  50

 ctg gtg gaa cca agc cca cca cat act gta aat aca ctc ttc ctg acc      364
 Leu Val Glu Pro Ser Pro Pro His Thr Val Asn Thr Leu Phe Leu Thr
  55                  60                  65                  70

 aat gac ctg act gag gaa gtg atg gag gag gtg ctg caa aag aag gca      412
 Asn Asp Leu Thr Glu Glu Val Met Glu Glu Val Leu Gln Lys Lys Ala
                  75                  80                  85

 gac ctc att ctc tcc tac cat ccg cct atc ttc cga ccc atg aag cgc      460
 Asp Leu Ile Leu Ser Tyr His Pro Pro Ile Phe Arg Pro Met Lys Arg
              90                  95                 100

 ata acc tgg aac aca tgg aag gag cgc ctg gtg atc cgg gct ctg gag      508
 Ile Thr Trp Asn Thr Trp Lys Glu Arg Leu Val Ile Arg Ala Leu Glu
         105                 110                 115

 aac aga gtc ggt atc tac tct cct cat aca gcc tat gat gct gcg ccc      556
 Asn Arg Val Gly Ile Tyr Ser Pro His Thr Ala Tyr Asp Ala Ala Pro
     120                 125                 130

 cag ggc gtc aac aac tgg ttg gct aaa ggg ctt gga gct tgt acc tcc      604
 Gln Gly Val Asn Asn Trp Leu Ala Lys Gly Leu Gly Ala Cys Thr Ser
 135                 140                 145                 150

 agg ccc ata cat cct tcc aaa gct ccc aac tac cct aca gag gga aac      652
 Arg Pro Ile His Pro Ser Lys Ala Pro Asn Tyr Pro Thr Glu Gly Asn
                 155                 160                 165

 cac cga gta gaa ttc aac gtt aac tac acc caa gac ctg gac aaa gtc      700
 His Arg Val Glu Phe Asn Val Asn Tyr Thr Gln Asp Leu Asp Lys Val
             170                 175                 180

 atg tct gca gtg aaa gga att gac ggt gtt tct gtc act tct ttt tct      748
 Met Ser Ala Val Lys Gly Ile Asp Gly Val Ser Val Thr Ser Phe Ser
         185                 190                 195

 gct agg act ggt aat gag gaa caa aca cgg att aat ctg aat tgt act      796
 Ala Arg Thr Gly Asn Glu Glu Gln Thr Arg Ile Asn Leu Asn Cys Thr
     200                 205                 210

 cag aag gct ttg atg cag gtg gta gat ttt ctt tcc cgg aac aaa caa      844
 Gln Lys Ala Leu Met Gln Val Val Asp Phe Leu Ser Arg Asn Lys Gln
 215                 220                 225                 230

 ctt tat cag aag acg gaa att ctg tca ctg gag aag cct ttg ctt cta      892
 Leu Tyr Gln Lys Thr Glu Ile Leu Ser Leu Glu Lys Pro Leu Leu Leu
                 235                 240                 245

 cat act gga atg gga cgg tta tgc aca ctg gat gaa tct gtc tcc ctg      940
 His Thr Gly Met Gly Arg Leu Cys Thr Leu Asp Glu Ser Val Ser Leu
             250                 255                 260

 gca acc atg att gat cga ata aaa aga cac cta aaa cta tct cat att      988
 Ala Thr Met Ile Asp Arg Ile Lys Arg His Leu Lys Leu Ser His Ile
         265                 270                 275

 cgc tta gcc ctt ggg gtg ggg aga acc tta gag tct caa gtc aaa gtc     1036
 Arg Leu Ala Leu Gly Val Gly Arg Thr Leu Glu Ser Gln Val Lys Val
     280                 285                 290

 gtg gcc ctg tgt gct ggt tct ggg agc agc gtt ctg cag ggt gtt gag     1084
 Val Ala Leu Cys Ala Gly Ser Gly Ser Ser Val Leu Gln Gly Val Glu
 295                 300                 305                 310

 gct gac ctt tac ctc aca ggt gag atg tcc cat cat gat att ttg gat     1132
 Ala Asp Leu Tyr Leu Thr Gly Glu Met Ser His His Asp Ile Leu Asp
                 315                 320                 325

 gct gct tcc caa gga ata aat gtc atc ctc tgt gaa cac agc aac act     1180
 Ala Ala Ser Gln Gly Ile Asn Val Ile Leu Cys Glu His Ser Asn Thr
             330                 335                 340

 gaa cga ggc ttt ctt tct gac ctt cga gat atg ctg gat tct cac ttg     1228
 Glu Arg Gly Phe Leu Ser Asp Leu Arg Asp Met Leu Asp Ser His Leu
         345                 350                 355

 gag aat aag ata aat att atc cta tca gag act gac agg gac cct ctt     1276
 Glu Asn Lys Ile Asn Ile Ile Leu Ser Glu Thr Asp Arg Asp Pro Leu
     360                 365                 370

 cag gtg gta taattgc agaaacatca ggataacaca ttctacaaat cagctggatg     1332
 Gln Val Val 
 375

 ccaacttaaa tttgtaacat gagtcagtgg gactggtgtg cttccagaga gtgtcttcga   1392

 gggtatcatc atttccggtt tgttaatctt attcaccaaa tgttctatcg ctcgtaaggt   1452

 aaaactgtaa tataactacc atattaaata acaaatgttc attataaact ctaggaaaga   1512

 ttgaataaaa tctgtttact taacattaaa aaaaaaaaaa aa                      1554




      <210> 70
      <211> 1113
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (343)..(660)

      <220>
      <221> misc_feature
      <222> (1)...(1113)
      <223> n = a,t,c or g

      <400> 70
 ggacgatctt ggctcaccgc aacctccgcc tactgggttc aagccattct cctgcctcag     60

 cttcccaagt agctgggatt acaggcatgt gctaccatgc ccagctaatt ttgtattttt    120

 agtagagaca gggtttctcc atgttgctca ggctggtctt gaactcctga cctcaggtga    180

 tccgcccgcc tcggactccc aaagtgctgg gattacaggc atgagccacc atgcctggcc    240

 ggatgtgaat tatcttaaaa attttcaggt aattctaatg ggccaaggtt gagaacccct    300

 gctctgggcc catccgagca ccaggctgtc acaaacgcat gc   atg cac tca cgc     354
                                                  Met His Ser Arg
                                                    1

 ccg tgg gct tgg ggg gct tcg gaa atg tgc ttc tgc ttt ttt gag atg      402
 Pro Trp Ala Trp Gly Ala Ser Glu Met Cys Phe Cys Phe Phe Glu Met
   5                  10                  15                  20

 ggg tct ttc tgt tgc cca tcc cgg agc aca gtg gca cga tca cag ctc      450
 Gly Ser Phe Cys Cys Pro Ser Arg Ser Thr Val Ala Arg Ser Gln Leu
                  25                  30                  35

 act gca gcc tcg acc tcc tgg gct cag gtg atc ctc ccg cct cag cct      498
 Thr Ala Ala Ser Thr Ser Trp Ala Gln Val Ile Leu Pro Pro Gln Pro
              40                  45                  50

 cct gag tgt ctg ctt ctg gtt ttc atg atg acc tgg ggc cca ggc ata      546
 Pro Glu Cys Leu Leu Leu Val Phe Met Met Thr Trp Gly Pro Gly Ile
          55                  60                  65

 cta cac ttg tgc tgt tca ggg gcc agt cct gca cca gga gcc cat cag      594
 Leu His Leu Cys Cys Ser Gly Ala Ser Pro Ala Pro Gly Ala His Gln
      70                  75                  80

 cca cag ctc cgc cga gaa gca ctg ata tgc aga gct aag cag ctt tgt      642
 Pro Gln Leu Arg Arg Glu Ala Leu Ile Cys Arg Ala Lys Gln Leu Cys
  85                  90                  95                 100

 ttc cac gtg gat cct gcg taggtt ttcttggtcc atccgtagac accgcactcc      696
 Phe His Val Asp Pro Ala 
                 105

 tgcagaggat cttctcggga tgccccactg tctctgtttt ccctcttcac tgaacactca    756

 gtcggggctc gccatgatgc ctctgtgtct gctggcttct cccccattgg aacagccttc    816

 ttggcacgcc acactgctag ctgctgggca ctgtgctttc tgcctttacc gttctgccgt    876

 gatgttgcca aaatagcagc aacaacaaca acaacaaagg ctgggcacct ggctcatgcc    936

 tgtattccca gcagttcgag atcagcctgg gcaacatgcc ccaactggac cctaggcaaa    996

 agtgagtggc actcctctgc caggactcca ggcaagcccc ggcatcttct tgctgccgtc   1056

 ccagacaaca gaagttacca gatgaacaga cttggatggg ccacggnggt ggagagc      1113




      <210> 71
      <211> 707
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (169)..(552)

      <400> 71
 ggaagaatta ataaagatct tttttttttt ttttttttga gagacggagt ttcactctgt     60

 cccccaggct ggagtgcagt agtgtgatct cggctcactg caacttcttg tctccggggt    120

 tcaagcgatt ctcctgcctc agcttcccta gtagtgggga ctacaggc atg cac cac     177
                                                      Met His His
                                                        1

 cat gtc cag cta att ttt gta ttt ttt agt aga gac ggg gtt tca cta      225
 His Val Gln Leu Ile Phe Val Phe Phe Ser Arg Asp Gly Val Ser Leu
       5                  10                  15

 tat gtt ggc cag gct ggt ctc aaa ctt ctg acc tca agt gat cca ctc      273
 Tyr Val Gly Gln Ala Gly Leu Lys Leu Leu Thr Ser Ser Asp Pro Leu
  20                  25                  30                  35

 acc ttg gcc tcc caa agt gct ggg att aca gac gtg agc cac cat gcc      321
 Thr Leu Ala Ser Gln Ser Ala Gly Ile Thr Asp Val Ser His His Ala
                  40                  45                  50

 cgg cca gga ttt tcc act ctt gaa ggg agt att ttg ttg tca ctt caa      369
 Arg Pro Gly Phe Ser Thr Leu Glu Gly Ser Ile Leu Leu Ser Leu Gln
              55                  60                  65

 ctc gct gtt ttt ttt cca gac aac ctc aaa tat gac cac act aca gcc      417
 Leu Ala Val Phe Phe Pro Asp Asn Leu Lys Tyr Asp His Thr Thr Ala
          70                  75                  80

 tgt aca caa caa gac agt tta tct tgt cca tgg ggt aag tgt atg cct      465
 Cys Thr Gln Gln Asp Ser Leu Ser Cys Pro Trp Gly Lys Cys Met Pro
      85                  90                  95

 gat ctt ttt aat tca gta caa tct ctg aag gtg tta aca cta atg ttt      513
 Asp Leu Phe Asn Ser Val Gln Ser Leu Lys Val Leu Thr Leu Met Phe
 100                 105                 110                 115

 tac aag aat gta gag gcg act cgg tgc tat gaa gcg tgt taaacaactc       562
 Tyr Lys Asn Val Glu Ala Thr Arg Cys Tyr Glu Ala Cys 
                 120                 125

 acacaattgc tacaaaacac cagggagggg ctttttgtgt ttttaatttt taaaacattt    622

 ttccttttct tgtgagccat agtaggccta gagagattac tgggttttta taattaaaca    682

 tttatttcgg tgaaaaaaaa aaaaa                                          707




      <210> 72
      <211> 990
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(557)

      <400> 72
 ttacaaatag acgctaagga gggtgatggt ggctatgatg gtggggatga tgaggctatt     60

 gtttttctcg gcgctcagga agc    atg gca ctc tgg cgg gca tac cag cgg     110
                              Met Ala Leu Trp Arg Ala Tyr Gln Arg
                                1               5

 gcc ctg gcc gct cac ccg tgg aaa gta cag gtc ctg aca gct ggg tcc      158
 Ala Leu Ala Ala His Pro Trp Lys Val Gln Val Leu Thr Ala Gly Ser
  10                  15                  20                  25

 ctg atg ggc ctg ggt gac att atc tca cag cag ctg gtg gag agg cgg      206
 Leu Met Gly Leu Gly Asp Ile Ile Ser Gln Gln Leu Val Glu Arg Arg
                  30                  35                  40

 ggt ctg cag gaa cac cag aga ggc cgg act ctg acc atg gtg tcc ctg      254
 Gly Leu Gln Glu His Gln Arg Gly Arg Thr Leu Thr Met Val Ser Leu
              45                  50                  55

 ggc tgt ggc ttt gtg ggc cct gtg gta gga ggc tgg tac aag gtt ttg      302
 Gly Cys Gly Phe Val Gly Pro Val Val Gly Gly Trp Tyr Lys Val Leu
          60                  65                  70

 gat cgg ttc atc cct ggc acc acc aaa gtg gat gca ctg aag aag atg      350
 Asp Arg Phe Ile Pro Gly Thr Thr Lys Val Asp Ala Leu Lys Lys Met
      75                  80                  85

 ttg ttg gat cag ggg ggc ttt gcc ccg tgt ttt cta ggc tgc ttt ctc      398
 Leu Leu Asp Gln Gly Gly Phe Ala Pro Cys Phe Leu Gly Cys Phe Leu
  90                  95                 100                 105

 cca ctg gat tat cct gat gcc ctt atc acc aac tac tat cta tgg cct      446
 Pro Leu Asp Tyr Pro Asp Ala Leu Ile Thr Asn Tyr Tyr Leu Trp Pro
                 110                 115                 120

 gct gtg cag tta gcc aac ttc tac ctg gtc ccc ctt cat tac agg ttg      494
 Ala Val Gln Leu Ala Asn Phe Tyr Leu Val Pro Leu His Tyr Arg Leu
             125                 130                 135

 gcc gtt gtc caa tgt gtt gct gtt atc tgg aac tcc tac ctg tcc tgg      542
 Ala Val Val Gln Cys Val Ala Val Ile Trp Asn Ser Tyr Leu Ser Trp
         140                 145                 150

 aag gca cat cgg ctc taagcctgcc tcactccatc gtttccacct tgcagtgatg      597
 Lys Ala His Arg Leu 
     155

 cagcttgacc ctggaacggt cagacaacct cctcaaagtg ggcataccag tttccacggg    657

 gttgggttgc cggtcagagc ttaagaggac tagcaccctg caatgcccct cttcactcta    717

 aaatgtacac tgactgcttt agagcccttg ataatagtct tattcccacc acatactagg    777

 cactccataa atatctgttg aaccttcatg accttatcaa ctttacaccc atatcccagc    837

 aaatgccact catccccact cttcatagac acatttgtta ctctaaccct gcctaggctt    897

 cttgtagctc cagctcttta gagactcccg gaacccttta tatggtgcct cagtaaatat    957

 gttattaaat atgtaatccg gaaaaaaaaa aaa                                 990




      <210> 73
      <211> 1143
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(822)

      <400> 73
 cctttcgttc gacccacgcc tccgggacag cagagacaac agtcacagta accctgtcta     60

 gagcgttcct ggagcccaag ctcctctcca cagaggagga cagagcaggc agcagagacc    120
                                                                 
 atg ggg ccc ccc tca gct tgt ccc cac aga gaa tgc atc ccc tgg cag      168
 Met Gly Pro Pro Ser Ala Cys Pro His Arg Glu Cys Ile Pro Trp Gln
   1               5                  10                  15

 ggg ctc ttg ctc aca gcc tca ctt tta act ttc tgg aac gca ccc acc      216
 Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Ala Pro Thr
              20                  25                  30

 act gcc tgg ctc ttt att gca tca gcg ccc ttt gaa gtt gct gaa ggg      264
 Thr Ala Trp Leu Phe Ile Ala Ser Ala Pro Phe Glu Val Ala Glu Gly
          35                  40                  45

 gag aat gtt cat ctc tct gtg gtt tat ctg ccc gag aat ctc tac agc      312
 Glu Asn Val His Leu Ser Val Val Tyr Leu Pro Glu Asn Leu Tyr Ser
      50                  55                  60

 tat ggc tgg tac aaa ggg aaa acg gtg gag ccc aac cag cta atc gca      360
 Tyr Gly Trp Tyr Lys Gly Lys Thr Val Glu Pro Asn Gln Leu Ile Ala
  65                  70                  75                  80

 gca tat gta ata gac gac act cac gtt agg act cca ggg cct gca tac      408
 Ala Tyr Val Ile Asp Asp Thr His Val Arg Thr Pro Gly Pro Ala Tyr
                  85                  90                  95

 agc ggt cga gag aca ata tca ccc agt gga gat ctg cat ttc cag aag      456
 Ser Gly Arg Glu Thr Ile Ser Pro Ser Gly Asp Leu His Phe Gln Lys
             100                 105                 110

 gtc acc cta gag gac acg gga tac tac acc cta caa gtc aca tac aga      504
 Val Thr Leu Glu Asp Thr Gly Tyr Tyr Thr Leu Gln Val Thr Tyr Arg
         115                 120                 125

 aat tct cag att gaa cag gca tct cac cat ctc cgt gta tac gag tca      552
 Asn Ser Gln Ile Glu Gln Ala Ser His His Leu Arg Val Tyr Glu Ser
     130                 135                 140

 gtg gct cag ccc tcc atc caa gcc agc agc acc aca gtc aca gag aag      600
 Val Ala Gln Pro Ser Ile Gln Ala Ser Ser Thr Thr Val Thr Glu Lys
 145                 150                 155                 160

 ggc tcc gtg gtc ctg acc tgc cac aca aat aac act gga acc tct ttc      648
 Gly Ser Val Val Leu Thr Cys His Thr Asn Asn Thr Gly Thr Ser Phe
                 165                 170                 175

 cag tgg att ttc aac acc cag cgt ctg cag gtc acg aag agg atg aag      696
 Gln Trp Ile Phe Asn Thr Gln Arg Leu Gln Val Thr Lys Arg Met Lys
             180                 185                 190

 ctg tcc tgg ttt aac cat atg ctc acc ata gac ccc atc agg cag gag      744
 Leu Ser Trp Phe Asn His Met Leu Thr Ile Asp Pro Ile Arg Gln Glu
         195                 200                 205

 gac gct ggg gag aat caa tgg gag gtc tcc aac cca atc agc tcc aac      792
 Asp Ala Gly Glu Asn Gln Trp Glu Val Ser Asn Pro Ile Ser Ser Asn
     210                 215                 220

 agg agc gac ccc ctc aag ctg act gga aaa t aagatgacac actctaggca      843
 Arg Ser Asp Pro Leu Lys Leu Thr Gly Lys 
 225                 230

 ttccggacgg gcgcctgggt tggaggtttc tgagggcggc acttggtggt ccctgacctc    903

 caaaaactgt caggcccggc gatcgaggga cgttagtggc gaaggcccca ggcccacccc    963

 ggccatggac cctttggaag atcatctctt aaatccctag ccagcacgag gaactgctta   1023

 atatatgaga ggggaggacc aagcaacgtg ggctcctgcg ccgccacgaa ccaggaatga   1083

 gccaccgatg tggcgagcga gcgacgctaa cgacgtggca cgtaagcgag cgtgcacggc   1143




      <210> 74
      <211> 2706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (22)..(1575)

      <400> 74
 aaatttgaat accacagtag c  atg gag tgt gac ctc atg gag act gac atc      51
                          Met Glu Cys Asp Leu Met Glu Thr Asp Ile
                            1               5                  10

 ttg gag tcg ttg gaa gat cta ggt tac aag ggc cca ttg ttg gaa gat       99
 Leu Glu Ser Leu Glu Asp Leu Gly Tyr Lys Gly Pro Leu Leu Glu Asp
                  15                  20                  25

 gga gcg ctc tct cag gca gtc tct gct gga gcc agt tcc ccc gag ttt      147
 Gly Ala Leu Ser Gln Ala Val Ser Ala Gly Ala Ser Ser Pro Glu Phe
              30                  35                  40

 acc aaa ctc tgt gct tgg ctg gtg tct gaa tta aga gtg ctc tgt aaa      195
 Thr Lys Leu Cys Ala Trp Leu Val Ser Glu Leu Arg Val Leu Cys Lys
          45                  50                  55

 cta gag gaa aac gtg caa gca act aac agt ccg agt gaa gct gaa gaa      243
 Leu Glu Glu Asn Val Gln Ala Thr Asn Ser Pro Ser Glu Ala Glu Glu
      60                  65                  70

 ttc cag ctt gag gtg agt ggg cta cta ggg gag atg aac tgc ccg tat      291
 Phe Gln Leu Glu Val Ser Gly Leu Leu Gly Glu Met Asn Cys Pro Tyr
  75                  80                  85                  90

 ctt tca ctg aca tct ggg gat gtg acc aag cgc ctt ctc att cag aag      339
 Leu Ser Leu Thr Ser Gly Asp Val Thr Lys Arg Leu Leu Ile Gln Lys
                  95                 100                 105

 aac tgc ctc ctc ttg ctc aca tac ctc atc tca gaa cta gaa gct gcc      387
 Asn Cys Leu Leu Leu Leu Thr Tyr Leu Ile Ser Glu Leu Glu Ala Ala
             110                 115                 120

 aga atg ctc tgt gtg aat gct cct cca aaa aaa gct caa gaa gga ggc      435
 Arg Met Leu Cys Val Asn Ala Pro Pro Lys Lys Ala Gln Glu Gly Gly
         125                 130                 135

 ggt agt gag gtc ttt caa gag ttg aaa ggc ata tgt att gct cta gga      483
 Gly Ser Glu Val Phe Gln Glu Leu Lys Gly Ile Cys Ile Ala Leu Gly
     140                 145                 150

 atg tcc aaa cct cca gcc aat ata act atg ttc caa ttc ttc agc ggg      531
 Met Ser Lys Pro Pro Ala Asn Ile Thr Met Phe Gln Phe Phe Ser Gly
 155                 160                 165                 170

 att gaa aaa aaa tta aag gaa aca tta gca aaa gtt cca cct aat cat      579
 Ile Glu Lys Lys Leu Lys Glu Thr Leu Ala Lys Val Pro Pro Asn His
                 175                 180                 185

 gtg gga aag cct tta ctg aag aag cca atg gga cca gcc cac tgg gaa      627
 Val Gly Lys Pro Leu Leu Lys Lys Pro Met Gly Pro Ala His Trp Glu
             190                 195                 200

 aag ata gaa gca att aac caa gcc ata gcc aat gaa tat gaa gtc cgg      675
 Lys Ile Glu Ala Ile Asn Gln Ala Ile Ala Asn Glu Tyr Glu Val Arg
         205                 210                 215

 aga aag ctg cta ata aaa cgt ttg gat gtc act gta caa tcc ttt ggc      723
 Arg Lys Leu Leu Ile Lys Arg Leu Asp Val Thr Val Gln Ser Phe Gly
     220                 225                 230

 tgg tct gac aga gct aag agc cag aca gaa aaa tta gcc aag gtt tac      771
 Trp Ser Asp Arg Ala Lys Ser Gln Thr Glu Lys Leu Ala Lys Val Tyr
 235                 240                 245                 250

 cag ccg aaa cgt tca gtc tta tcc cct aaa act act att tct gtt gcc      819
 Gln Pro Lys Arg Ser Val Leu Ser Pro Lys Thr Thr Ile Ser Val Ala
                 255                 260                 265

 cat ctt ttg gct gca agg cag gac ttg tca aag att tta agg aca agc      867
 His Leu Leu Ala Ala Arg Gln Asp Leu Ser Lys Ile Leu Arg Thr Ser
             270                 275                 280

 agc ggc tct ata aga gaa aag act gcc tgt gcc atc aat aag gtg ttg      915
 Ser Gly Ser Ile Arg Glu Lys Thr Ala Cys Ala Ile Asn Lys Val Leu
         285                 290                 295

 atg ggc agg gtg cct gac aga ggt ggt aga ccc aat gaa atc gaa cct      963
 Met Gly Arg Val Pro Asp Arg Gly Gly Arg Pro Asn Glu Ile Glu Pro
     300                 305                 310

 cca ccc cca gag atg cca ccg tgg cag aag agg caa gat ggc ccc cag     1011
 Pro Pro Pro Glu Met Pro Pro Trp Gln Lys Arg Gln Asp Gly Pro Gln
 315                 320                 325                 330

 cag caa aca gga ggc cga gga gga ggg aga ggt ggc tat gaa cat tcc     1059
 Gln Gln Thr Gly Gly Arg Gly Gly Gly Arg Gly Gly Tyr Glu His Ser
                 335                 340                 345

 tca tac gga gga cga gga ggt cat gaa caa gga ggc ggg aga ggt gga     1107
 Ser Tyr Gly Gly Arg Gly Gly His Glu Gln Gly Gly Gly Arg Gly Gly
             350                 355                 360

 cgt ggt ggc tat gac cat ggt ggc cga ggg gga gga aga gga aat aag     1155
 Arg Gly Gly Tyr Asp His Gly Gly Arg Gly Gly Gly Arg Gly Asn Lys
         365                 370                 375

 cat caa gga ggc tgg aca gat gga ggg agt ggt gga gga ggt ggc tac     1203
 His Gln Gly Gly Trp Thr Asp Gly Gly Ser Gly Gly Gly Gly Gly Tyr
     380                 385                 390

 caa gat ggt ggt tat cga gat tca ggt ttc cag cca ggt ggc tat cat     1251
 Gln Asp Gly Gly Tyr Arg Asp Ser Gly Phe Gln Pro Gly Gly Tyr His
 395                 400                 405                 410

 ggt ggc cac agc agt ggt ggc tat caa ggc gga ggt tat ggt ggc ttc     1299
 Gly Gly His Ser Ser Gly Gly Tyr Gln Gly Gly Gly Tyr Gly Gly Phe
                 415                 420                 425

 caa aca tct tct tca tat aca gga agt gga tac cag ggt ggt ggc tac     1347
 Gln Thr Ser Ser Ser Tyr Thr Gly Ser Gly Tyr Gln Gly Gly Gly Tyr
             430                 435                 440

 cag cag gac aat aga tac caa gat ggc ggg cac cat ggt gat cgt ggt     1395
 Gln Gln Asp Asn Arg Tyr Gln Asp Gly Gly His His Gly Asp Arg Gly
         445                 450                 455

 ggt ggt cgt ggt ggg cga ggt ggt cgt gga ggc cga ggt ggt cgt gca     1443
 Gly Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly Arg Ala
     460                 465                 470

 ggc cag gga gga ggc tgg gga gga aga ggg agc cag aat tat cac caa     1491
 Gly Gln Gly Gly Gly Trp Gly Gly Arg Gly Ser Gln Asn Tyr His Gln
 475                 480                 485                 490

 ggg ggt caa ttt gaa cag cat ttc cag cat gga ggt tat cag tat aat     1539
 Gly Gly Gln Phe Glu Gln His Phe Gln His Gly Gly Tyr Gln Tyr Asn
                 495                 500                 505

 cat tct gga ttt gga cag gga aga cat tac act agt tgag gctaccgaac     1589
 His Ser Gly Phe Gly Gln Gly Arg His Tyr Thr Ser 
             510                 515

 cttacatttt gctagagctc aagtaataga aacttagttt cagaatcctg aattcagcac   1649

 ctattttgaa ttaatgtgag accacaggtg gcaggcagat tcctgcttgg cataagcatt   1709

 tgtaggtctt cattcaattc tgttagattt ttttattgga cttacataat gccgtttatt   1769

 tgagaaacac ataacatctc tcctttctat gaaaaatttt ttaaaaggtg gttaaaattg   1829

 cctttaattg cccagtagac taattccaca gtcagaacat gcaaactttt ttgaagaaat   1889

 tacttgaata agtagttttc atgttttcaa tatgcagttt tgaaaatgag gattcaccta   1949

 gactttttta gatttactac taggaaacct tcctcatatg aataaccatt tatatgtgtt   2009

 ttgcttaaag tattccaatg cctattttcc aagcacagtt ctgccccccg gttgactttt   2069

 atgccacgtg tgcttcatga tggaactttt aggtcagttc ctattaaatg agctcttctg   2129

 cagatagcac attcagtagc cttattttgt tgatggaata ctgtatcata tgctcaactc   2189

 tgaaaacctt gaacacggcc aaaatccata aagattataa aagcaaacta agttgtgaag   2249

 ctatagtaca tgtaggcatt tagttaagta tagcaattca aactgacctg catccatcca   2309

 aaacaaattc ctccttcaac cttattttta cttgaaattt gctagaagaa atagcaaacc   2369

 gaaatttgtt ttatgcatga gttaatacca ctggctcagc aaatacaagt tagtttgctt   2429

 taagcaggta actttttttg taatggaaga aatgcactac aaagttaaga cagatttttg   2489

 ctaagtgcag gaggcccttt attattgctg cagaaaacaa aagcctggct gagttgatgt   2549

 tttacattct cccttactga aatctacatg acatgatgct tcttgctggg tttttgtaca   2609

 tgtaaacatt gtcaagctgt gaaagaaaat ggctggaggt gtgctttgtg tgaaaggtga   2669

 gcaataaagt atctgttaag ttctctcaaa aaaaaaa                            2706




      <210> 75
      <211> 1602
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(716)

      <400> 75
 ccacgcgtcc gctg  atg ctg aaa gag agc aat ttt gct gac agt tat tat      50
                  Met Leu Lys Glu Ser Asn Phe Ala Asp Ser Tyr Tyr
                    1               5                  10

 gac tac att tgt att att gac ttt gaa gcc act tgt gaa gaa gga aac       98
 Asp Tyr Ile Cys Ile Ile Asp Phe Glu Ala Thr Cys Glu Glu Gly Asn
          15                  20                  25

 cca ccg gag ttt gta cat gaa ata att gaa ttt ccg gtt gtt tta ctg      146
 Pro Pro Glu Phe Val His Glu Ile Ile Glu Phe Pro Val Val Leu Leu
      30                  35                  40

 aat acg cat act tta gaa ata gaa gac acg ttt cag cag tat gta aga      194
 Asn Thr His Thr Leu Glu Ile Glu Asp Thr Phe Gln Gln Tyr Val Arg
  45                  50                  55                  60

 cca gag att aac aca cag ctg tct gat ttc tgc atc agt cta act gga      242
 Pro Glu Ile Asn Thr Gln Leu Ser Asp Phe Cys Ile Ser Leu Thr Gly
                  65                  70                  75

 att act cag gat cag gta gac aga gct gat acc ttc cct cag gta cta      290
 Ile Thr Gln Asp Gln Val Asp Arg Ala Asp Thr Phe Pro Gln Val Leu
              80                  85                  90

 aaa aaa gta att gac tgg atg aaa ttg aag gaa tta gga aca aag tat      338
 Lys Lys Val Ile Asp Trp Met Lys Leu Lys Glu Leu Gly Thr Lys Tyr
          95                 100                 105

 aaa tac tca ctt tta aca gat ggt tct tgg gat atg agt aag ttc ttg      386
 Lys Tyr Ser Leu Leu Thr Asp Gly Ser Trp Asp Met Ser Lys Phe Leu
     110                 115                 120

 aac att cag tgt caa ctc agc agg ctc aaa tac cct cct ttt gcg aaa      434
 Asn Ile Gln Cys Gln Leu Ser Arg Leu Lys Tyr Pro Pro Phe Ala Lys
 125                 130                 135                 140

 aag tgg atc aat att cgg aag tca tat gga aat ttt tac aag gtt cct      482
 Lys Trp Ile Asn Ile Arg Lys Ser Tyr Gly Asn Phe Tyr Lys Val Pro
                 145                 150                 155

 aga agc caa acc aaa ctg aca ata atg ctt gaa aaa tta gga atg gat      530
 Arg Ser Gln Thr Lys Leu Thr Ile Met Leu Glu Lys Leu Gly Met Asp
             160                 165                 170

 tat gat ggg cgg cct cac tgt ggt ctt gat gac tct aag aat atc gcc      578
 Tyr Asp Gly Arg Pro His Cys Gly Leu Asp Asp Ser Lys Asn Ile Ala
         175                 180                 185

 cga ata gca gtt cga atg ctt cag gat ggg tgt gaa ctc cga atc aac      626
 Arg Ile Ala Val Arg Met Leu Gln Asp Gly Cys Glu Leu Arg Ile Asn
     190                 195                 200

 gag aaa atg cat gca gga cag cta atg agt gtg tcc tct tcc tta cca      674
 Glu Lys Met His Ala Gly Gln Leu Met Ser Val Ser Ser Ser Leu Pro
 205                 210                 215                 220

 ata gag ggc act cca cca cca caa atg cca cat ttt aga aag taacaac      723
 Ile Glu Gly Thr Pro Pro Pro Gln Met Pro His Phe Arg Lys 
                 225                 230

 agttttgtgt gtggatcatt ccaattgaag ttgctatgaa gaggtagcag atgaatctca    783

 ttgaattagt cctgtagtgc aaactttaag caccttaaaa catttaaaat cttattacag    843

 gtgatagaga tagatacatg tatgtgaaca gattttgtag gaaggcatac tgaattcttt    903

 gtcaccagca cttttgatat gaacagtatt cgttacatag taacagttcc tgcttacaac    963

 tgaattttat aatttaaggt gttcaagata tattcttttt ggttttaaaa tgcaaaatct   1023

 tattggctgt tctgttgaat gtcatatctt actggtgttt aaatatgtaa tgtgtttctt   1083

 tattaacatc actagatgaa accatatctt aaaatgcaga aatgattgga aggtagatct   1143

 tatctagcct ttggatttca agaatatcat agtccttttg attttcaaag tttatatgtg   1203

 aagttcacca tgtatgtggt gaatttcgta aggtacttgg tatacatatc tgcctatgtt   1263

 tcttttcaac tcataattgg aagaattatg atggattata gggtttggtt aaaaatccag   1323

 ttactgaagg aattaatgaa aacgtagaag aaagtactaa aaggaatatc ataagggctg   1383

 tagctcaaac ttcataatac ataaatcact ggggtctttt tggatttggt tgtttgattc   1443

 gccttccttt tttgacatat gtatgcctta attcttaaat ctgagggacc atgctttgaa   1503

 atagactgaa aattaagggt caccacctaa ttttactttg tattcagtat cgtaagtgag   1563

 gttaataaag tcaatacttt ctaccataaa aaaaaaaaa                          1602




      <210> 76
      <211> 592
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (65)..(589)

      <400> 76
 tttcgtctcg ctgcacattt gcttctgaca caactgtgtt cactagcaac ctcaaacaga     60

 cacc atg gtg cac ctg act cct gag gag aag tct gcc gtt act gcc ctg     109
      Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu
        1               5                  10                  15

 tgg ggc aag gtg aac gtg gat gaa gtt ggt ggt gag gcc ctg ggc agg      157
 Trp Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg
                  20                  25                  30

 ctg ctg gtg gtc tac cct tgg acc cag agg ttc ttt gag tcc ttt ggg      205
 Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly
              35                  40                  45

 gat ctg tcc act cct gat gct gtt atg ggc aac cct aag gtg aag gct      253
 Asp Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala
          50                  55                  60

 cat ggc aag aaa gtg ctc ggt gcc ttt agt gat ggc ctg gct cac ctg      301
 His Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu
      65                  70                  75

 gac aac ctc aag ggc acc ttt gcc aca ctg agt gag ctg cac tgt gac      349
 Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp
  80                  85                  90                  95

 aag ctg cac gtg gat cct gag aac ttc agg ctc ctg ggc aac gtg ctg      397
 Lys Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu
                 100                 105                 110

 gtc tgt gtg ctt gcc cat cac ttt ggc aaa gaa ttc acc cca cca gtg      445
 Val Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val
             115                 120                 125

 cag cca cac cta tca gtg gtg tgg cta atg ccc tgg ccc aca act cct      493
 Gln Pro His Leu Ser Val Val Trp Leu Met Pro Trp Pro Thr Thr Pro
         130                 135                 140

 ggg caa cgt gct ggt ctg tgt gct ggc cca tca ctt tgg caa ata att      541
 Gly Gln Arg Ala Gly Leu Cys Ala Gly Pro Ser Leu Trp Gln Ile Ile
     145                 150                 155

 cac ccc acc agt gca ggc tgc cta tca gaa agt ggt ggc tgg tgt ggc      589
 His Pro Thr Ser Ala Gly Cys Leu Ser Glu Ser Gly Gly Trp Cys Gly 
 160                 165                 170                 175

 taa                                                                  592




      <210> 77
      <211> 418
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(259)

      <400> 77
 ggatttatag ggcaggtcat gggcaactga cccacatgaa aaaccaattg aattttaaat     60

 tcctcggcca gaggttaaat caagttatat ttcactcata aaatttctta acttgggcag    120

 agatactgtc ctttaatcaa tcttcaatgc tgcttaaata ataagtgtta agagatgg      178                                                                 
 atg gag cct ggc caa cat ggc aaa aca cca cct cca cta aaa ata caa      226
 Met Glu Pro Gly Gln His Gly Lys Thr Pro Pro Pro Leu Lys Ile Gln
   1               5                  10                  15

 aga ttg gct ggg cat tcc agg tgc tta ggg ggc tgagacat aagaattgct      277
 Arg Leu Ala Gly His Ser Arg Cys Leu Gly Gly 
              20                  25

 tgaacccggg agatggaggt tgcagtgaac cgagagtgtt ccactgcact ccagcctggg    337

 tgacagagga agaccctgtc tccctgtcta aaaaaagaga gatggatggg aataatacta    397

 ccttcacacc aagccagttg a                                              418




      <210> 78
      <211> 2295
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (986)..(2182)

      <400> 78
 gcaatttcat aatatggtaa tttttaatat taaaagtaaa ttgtaaatgt gtctttataa     60

 acaatatgca taaaatagat catattctaa acccttttct ttttaaaacg ctttttcaca    120

 gtaaatttct tatggtcaga ttttccctca gaatagtgca actggaagaa gggaaatgtt    180

 ggcagtggct caggactctc tgctagtaca agtccttgta gatctcctgc aggagcgggt    240

 gaagactcat gtctgtctcc gtcttcttga tcacctgcag tagctgcacg tgttccgtga    300

 caatctgtct gaggtctgtc attttctgga gcagcttggc aaacagctgt gaggactcag    360

 ggtggttcag cttcagctgg agctccaggg cttgtagcag gttgtcttga atgtcttcaa    420

 tgggcttcac attcagcaaa cctgggcggt ctccactgag aataatgaca gcaataaata    480

 ttgccaagtc gctgtcatct aattccagtg cattgaactt cacagcaaac tcaaacttgg    540

 gctccataaa gtcaccaaaa ggctttcgca ggctctttag aaactccctt gtcatgaagc    600

 cttggccctc ggatatgaga accccatctt tattcatcaa ggaggccagc attgtgtaaa    660

 tgatctcgtg gactccatat ttgaggagag ttacttggtc gttcaagtca agatttacaa    720

 aaccaggaat gcttttggca tactctgtga tctcctgcac agcctccacg gagcgaaact    780

 ggcagccctg aaagatgcgg atggccacct ctttgctctg ctcctgcagg ggggtgatgt    840

 gtttgaactt gattttatct tctcccatca ttaaggaatt catgtcatag ataacgaatg    900

 gtgatttgtc tgttgtcttt cctgtcaaga tcgccctcgc ctttgctttg gtcagcggga    960

 aggactttat gtatgagtca tacaa  atg ttt tgc cag ggc ctg acg gag gtc    1012
                              Met Phe Cys Gln Gly Leu Thr Glu Val
                                1               5

 agc gga ctc tgg att cag ctg gtc gat atc act gga gat ctc cgc caa     1060
 Ser Gly Leu Trp Ile Gln Leu Val Asp Ile Thr Gly Asp Leu Arg Gln
  10                  15                  20                  25

 cag ctt ctc ctt ctc ggc ctg tgc gat ccg ccc aaa cct gat ggc att     1108
 Gln Leu Leu Leu Leu Gly Leu Cys Asp Pro Pro Lys Pro Asp Gly Ile
                  30                  35                  40

 atg aga cat ccc cac tgc aag gca ttt ctg aaa ccg aca gta ctg aca     1156
 Met Arg His Pro His Cys Lys Ala Phe Leu Lys Pro Thr Val Leu Thr
              45                  50                  55

 ttt att tct act ttt ttt gtg gat ccg aca gtt aag atc aca tct gtc     1204
 Phe Ile Ser Thr Phe Phe Val Asp Pro Thr Val Lys Ile Thr Ser Val
          60                  65                  70

 ata gat aag ctt caa tct gat tgt tct ccg gaa gaa acc ctt gca tcc     1252
 Ile Asp Lys Leu Gln Ser Asp Cys Ser Pro Glu Glu Thr Leu Ala Ser
      75                  80                  85

 ttc aca agc atg aac tcc ata gtg aaa tcc aga agc ttt atc tcc aca     1300
 Phe Thr Ser Met Asn Ser Ile Val Lys Ser Arg Ser Phe Ile Ser Thr
  90                  95                 100                 105

 gac acg aca ttc aat tgc cat gag gga gtt gga agg ctc ttc atg agg     1348
 Asp Thr Thr Phe Asn Cys His Glu Gly Val Gly Arg Leu Phe Met Arg
                 110                 115                 120

 ctt att gta gag ctg agt ctt ctc aga ata ata agg tgg aga tgc agg     1396
 Leu Ile Val Glu Leu Ser Leu Leu Arg Ile Ile Arg Trp Arg Cys Arg
             125                 130                 135

 ctc cac ttt gat tgc act ttg gta ctc ttg aag ttt cag gtc ata ctt     1444
 Leu His Phe Asp Cys Thr Leu Val Leu Leu Lys Phe Gln Val Ile Leu
         140                 145                 150

 gta atc tgc aac cac tgg atc tgt tct tgt gaa tgg aat gtc ttc gta     1492
 Val Ile Cys Asn His Trp Ile Cys Ser Cys Glu Trp Asn Val Phe Val
     155                 160                 165

 atg tgg agt aga aat gct gga gaa gtc aac agt agt gaa ggg ctt gat     1540
 Met Trp Ser Arg Asn Ala Gly Glu Val Asn Ser Ser Glu Gly Leu Asp
 170                 175                 180                 185

 atc aaa gga gtg gga gtg gtc ttc cat tac gga gag atc cac gga gct     1588
 Ile Lys Gly Val Gly Val Val Phe His Tyr Gly Glu Ile His Gly Ala
                 190                 195                 200

 gat ccc aaa gtt ggt ggg cca gaa tgc gat ctc tgt gtc aac cat ggt     1636
 Asp Pro Lys Val Gly Gly Pro Glu Cys Asp Leu Cys Val Asn His Gly
             205                 210                 215

 cat ttc tgc ggc cac ggc ggc gtg gcg ccc ctc tcc ggt gtc ctc gag     1684
 His Phe Cys Gly His Gly Gly Val Ala Pro Leu Ser Gly Val Leu Glu
         220                 225                 230

 gcc gac cca agc ccc cca ggc ggc ggc tgc ggc tcg ggc tcg gga att     1732
 Ala Asp Pro Ser Pro Pro Gly Gly Gly Cys Gly Ser Gly Ser Gly Ile
     235                 240                 245

 cca cag act cag aga gaa ccc acc atg gtg ctg tct cct gcc gac aag     1780
 Pro Gln Thr Gln Arg Glu Pro Thr Met Val Leu Ser Pro Ala Asp Lys
 250                 255                 260                 265

 acc aac gtc aag gcc gcc tgg ggt aag gtc ggc gcg cac gct ggc gag     1828
 Thr Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu
                 270                 275                 280

 tat ggt gcg gag gcc ctg gag agg atg ttc ctg tcc ttc ccc acc acc     1876
 Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr
             285                 290                 295

 aag acc tac ttc ccg cac ttc gac ctg agc cac ggc tct gcc cag gtt     1924
 Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Gln Val
         300                 305                 310

 aag ggc cac ggc aag aag gtg gcc gac gcg ctg acc aac gcc gtg gcg     1972
 Lys Gly His Gly Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala
     315                 320                 325

 cac gtg gac gac atg ccc aac gcg ctg tcc gcc ctg agc gac ctg cac     2020
 His Val Asp Asp Met Pro Asn Ala Leu Ser Ala Leu Ser Asp Leu His
 330                 335                 340                 345

 gcg cac aag ctt cgg gtg gac ccg gtc aac ttc aag ctc cta agc cac     2068
 Ala His Lys Leu Arg Val Asp Pro Val Asn Phe Lys Leu Leu Ser His
                 350                 355                 360

 tgc ctg ctg gtg acc ctg gcc gcc cac ctc ccc gcc gag ttc acc cct     2116
 Cys Leu Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr Pro
             365                 370                 375

 gcg gtg cac gcc tcc ctg gac aag ttc ctg gct tct gtg agc acc gtg     2164
 Ala Val His Ala Ser Leu Asp Lys Phe Leu Ala Ser Val Ser Thr Val
         380                 385                 390

 ctg acc tcc aaa tac cgt taagct ggagcctcgg tagccgttcc tcctgcccct     2218
 Leu Thr Ser Lys Tyr Arg 
     395

 tgggcctccc aacgggccct cctcccctcc ttgcacccgt acccccgtgg tctttgaata   2278

 aagtctgagt gggcggc                                                  2295




      <210> 79
      <211> 1536
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (121)..(831)

      <400> 79
 gttgggtgga aaaagacttt cttctctatt ttcctagtta tatatgctat catatgtctg     60

 tgtttctcct cttgaagttt ccctgaaacc tgggctcttg aagacgcatc actggagcag    120
                                                                 
 atg gat aat gga gac tgg ggc tat atg atg act gac cca gtc aca tta      168
 Met Asp Asn Gly Asp Trp Gly Tyr Met Met Thr Asp Pro Val Thr Leu
   1               5                  10                  15

 aat gta ggt gga cac ttg tat aca acg tct ctc acc aca ttg acg cgt      216
 Asn Val Gly Gly His Leu Tyr Thr Thr Ser Leu Thr Thr Leu Thr Arg
              20                  25                  30

 tac ccg gat tcc atg ctt gga gct atg ttt ggg ggg gac ttc ccc aca      264
 Tyr Pro Asp Ser Met Leu Gly Ala Met Phe Gly Gly Asp Phe Pro Thr
          35                  40                  45

 gct cga gac cct caa ggc aat tac ttt att gat cga gat gga cct ctt      312
 Ala Arg Asp Pro Gln Gly Asn Tyr Phe Ile Asp Arg Asp Gly Pro Leu
      50                  55                  60

 ttc cga tat gtc ctc aac ttc tta aga act tca gaa ttg acc tta ccg      360
 Phe Arg Tyr Val Leu Asn Phe Leu Arg Thr Ser Glu Leu Thr Leu Pro
  65                  70                  75                  80

 ttg gat ttt aag gaa ttt gat ctg ctt cgg aaa gaa gca gat ttt tac      408
 Leu Asp Phe Lys Glu Phe Asp Leu Leu Arg Lys Glu Ala Asp Phe Tyr
                  85                  90                  95

 cag att gag ccc ttg att cag tgt ctc aat gat cct aag cct ttg tat      456
 Gln Ile Glu Pro Leu Ile Gln Cys Leu Asn Asp Pro Lys Pro Leu Tyr
             100                 105                 110

 ccc atg gat act ttt gaa gaa gtt gtg gag ctg tct agt act cgg aag      504
 Pro Met Asp Thr Phe Glu Glu Val Val Glu Leu Ser Ser Thr Arg Lys
         115                 120                 125

 ctt tct aag tac tcc aac cca gtg gct gtc atc ata acg caa cta acc      552
 Leu Ser Lys Tyr Ser Asn Pro Val Ala Val Ile Ile Thr Gln Leu Thr
     130                 135                 140

 atc acc act aag gtc cat tcc tta cta gaa ggc atc tca aat tat ttt      600
 Ile Thr Thr Lys Val His Ser Leu Leu Glu Gly Ile Ser Asn Tyr Phe
 145                 150                 155                 160

 acc aag tgg aat aag cac atg atg gac acc aga gac tgc cag gtt tcc      648
 Thr Lys Trp Asn Lys His Met Met Asp Thr Arg Asp Cys Gln Val Ser
                 165                 170                 175

 ttt act ttt gga ccc tgt gat tat cac cag gaa gtt tct ctt agg gtc      696
 Phe Thr Phe Gly Pro Cys Asp Tyr His Gln Glu Val Ser Leu Arg Val
             180                 185                 190

 cac ctg atg gaa tac att aca aaa caa ggt ttc acg atc cgc aac acc      744
 His Leu Met Glu Tyr Ile Thr Lys Gln Gly Phe Thr Ile Arg Asn Thr
         195                 200                 205

 cgg gtg cat cac atg agt gag cgg gcc aat gaa aac aca gtg gag cac      792
 Arg Val His His Met Ser Glu Arg Ala Asn Glu Asn Thr Val Glu His
     210                 215                 220

 aac tgg act ttc tgt agg cta gcc cgg aag aca gac gac tgatctccga       841
 Asn Trp Thr Phe Cys Arg Leu Ala Arg Lys Thr Asp Asp 
 225                 230                 235

 ccctgccaca ggttcctgga aagactctcc aggaaatgga agatactgat tttttttttt    901

 aaatcacagg gggagatatt ttttttcttt taaatagttg tatttatttg aaggcaggga    961

 ggaccaaaag gaagttttgg gctttggcaa actcctccat gttttgttcc cttccccctg   1021

 agtatgcatg ggcctgttca aagtctccag ataccttttt tataaaaaga agcctgaaaa   1081

 tcattatggg atataatcta cccttaacag agcttttctt attacagtgc taaaatgatt   1141

 tctgataaaa tggtccctaa ctcaactaga aggctaaaaa tacaagaatg aaagaataag   1201

 cagagtactc atgatgcctt tgagaaaaat caaaacatca tgtagggtga cctagtttcc   1261

 aaaccaataa ataagtagta ttgtaatatt aaaggaaaac tgttccaatc atttaaaagt   1321

 acttattaag tactgctttt tacagttatg acaactgttt ctttctatgc atataaatca   1381

 aggaaccaaa tatctgtagc catggaaatg tctgactaga aatatttata ttgaattctg   1441

 aatacaaaat gtccctgtgg tagaaaactt actctttatg cctggtgcag tataattccc   1501

 aagtgtactg tctaccagaa aaaaaaagtc gacgc                              1536




      <210> 80
      <211> 535
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(441)

      <400> 80
 gcgtggctct ttattcgtga gttttccatt tacctccgct gaacctagag cttcagacgc     60

 cct  atg gcg tcc gcc tcg acc caa ccg gcg gcc ttg agc gct gag caa     108
      Met Ala Ser Ala Ser Thr Gln Pro Ala Ala Leu Ser Ala Glu Gln
        1               5                  10                  15

 gca aag gtg gtc ctc gcg gag gtg atc cag gcg ttc tcc gcc ccg gag      156
 Ala Lys Val Val Leu Ala Glu Val Ile Gln Ala Phe Ser Ala Pro Glu
                  20                  25                  30

 aat gca gtg cgc atg gac gag gct cgg gat aac gcc tgc aac gac atg      204
 Asn Ala Val Arg Met Asp Glu Ala Arg Asp Asn Ala Cys Asn Asp Met
              35                  40                  45

 ggt aag atg ctg caa ttc gtg ctg ccc gtg gcc acg cag atc cag cag      252
 Gly Lys Met Leu Gln Phe Val Leu Pro Val Ala Thr Gln Ile Gln Gln
          50                  55                  60

 gag gtt atc aaa gcc tat ggc ttc agc tgc gac ggg gaa ggt gtc ctt      300
 Glu Val Ile Lys Ala Tyr Gly Phe Ser Cys Asp Gly Glu Gly Val Leu
      65                  70                  75

 aag ttt gct cgc ttg gtc aag tcc tac gaa gcc cag gat cct gag atc      348
 Lys Phe Ala Arg Leu Val Lys Ser Tyr Glu Ala Gln Asp Pro Glu Ile
  80                  85                  90                  95

 gcc agc ctg tca ggc aag ctg aag gcg ctg ttt ctg ccg ccc atg acc      396
 Ala Ser Leu Ser Gly Lys Leu Lys Ala Leu Phe Leu Pro Pro Met Thr
                 100                 105                 110

 ctg cca ccc cat ggg cct gct gct ggt ggc agc gtg gcc gcc tcc tga      444
 Leu Pro Pro His Gly Pro Ala Ala Gly Gly Ser Val Ala Ala Ser 
             115                 120                 125

 gagttggccc tcccttgtgc cactgccagg ggaggaaagg ccttgatgtt ccagacaata    504

 ataaatgcgc ctgtgactta aaaaaaaaaa a                                   535




      <210> 81
      <211> 4885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (106)..(1860)

      <400> 81
 ccgacgattt cgtcgacggg ctgtggctgc ggaggatgag gggcgtccga ggcgcggagg     60

 ggctggctgg gcaggagggg ttggcggggc agcagggccg cggcc    atg ggg agc     114
                                                      Met Gly Ser
                                                        1

 ttg aag gag gag ctg ctc aaa gcc atc tgg cac gcc ttc acc gca ctc      162
 Leu Lys Glu Glu Leu Leu Lys Ala Ile Trp His Ala Phe Thr Ala Leu
       5                  10                  15

 gac cag gac cac agc ggc aag gtc tcc aag tcc cag ctc aag gtc ctt      210
 Asp Gln Asp His Ser Gly Lys Val Ser Lys Ser Gln Leu Lys Val Leu
  20                  25                  30                  35

 tcc cat aac ctg tgc acg gtg ctg aag gtt cct cat gac cca gtt gcc      258
 Ser His Asn Leu Cys Thr Val Leu Lys Val Pro His Asp Pro Val Ala
                  40                  45                  50

 ctt gaa gag cac ttc agg gat gat gat gag ggt cca gtg tcc aac cag      306
 Leu Glu Glu His Phe Arg Asp Asp Asp Glu Gly Pro Val Ser Asn Gln
              55                  60                  65

 ggc tac atg cct tat tta aac agg ttc att ttg gaa aag gtc caa gac      354
 Gly Tyr Met Pro Tyr Leu Asn Arg Phe Ile Leu Glu Lys Val Gln Asp
          70                  75                  80

 aac ttt gac aag att gaa ttc aat agg atg tgt tgg acc ctc tgt gtc      402
 Asn Phe Asp Lys Ile Glu Phe Asn Arg Met Cys Trp Thr Leu Cys Val
      85                  90                  95

 aaa aaa aac ctc aca aag aat ccc ctg ctc att aca gaa gaa gat gca      450
 Lys Lys Asn Leu Thr Lys Asn Pro Leu Leu Ile Thr Glu Glu Asp Ala
 100                 105                 110                 115

 ttt aaa ata tgg gtt att ttc aac ttt tta tct gag gac aag tat cca      498
 Phe Lys Ile Trp Val Ile Phe Asn Phe Leu Ser Glu Asp Lys Tyr Pro
                 120                 125                 130

 tta att att gtg tca gaa gag att gaa tac ctg ctt aag aag ctt aca      546
 Leu Ile Ile Val Ser Glu Glu Ile Glu Tyr Leu Leu Lys Lys Leu Thr
             135                 140                 145

 gaa gct atg gga gga ggt tgg cag caa gaa caa ttt gaa cat tat aaa      594
 Glu Ala Met Gly Gly Gly Trp Gln Gln Glu Gln Phe Glu His Tyr Lys
         150                 155                 160

 atc aac ttt gat gac agt aaa aat ggc ctt tct gca tgg gaa ctt att      642
 Ile Asn Phe Asp Asp Ser Lys Asn Gly Leu Ser Ala Trp Glu Leu Ile
     165                 170                 175

 gag ctt att gga aat gga cag ttt agc aaa ggc atg gac cgg cag act      690
 Glu Leu Ile Gly Asn Gly Gln Phe Ser Lys Gly Met Asp Arg Gln Thr
 180                 185                 190                 195

 gtg tct atg gca att aat gaa gtc ttt aat gaa ctt ata tta gat gtg      738
 Val Ser Met Ala Ile Asn Glu Val Phe Asn Glu Leu Ile Leu Asp Val
                 200                 205                 210

 tta aag cag ggt tac atg atg aaa aag ggc cac aga cgg aaa aac tgg      786
 Leu Lys Gln Gly Tyr Met Met Lys Lys Gly His Arg Arg Lys Asn Trp
             215                 220                 225

 act gaa aga tgg ttt gta cta aaa ccc aac ata att tct tac tat gtg      834
 Thr Glu Arg Trp Phe Val Leu Lys Pro Asn Ile Ile Ser Tyr Tyr Val
         230                 235                 240

 agt gag gat ctg aag gat aag aaa gga gac att ctc ttg gat gaa aat      882
 Ser Glu Asp Leu Lys Asp Lys Lys Gly Asp Ile Leu Leu Asp Glu Asn
     245                 250                 255

 tgc tgt gta gag tcc ttg cct gac aaa gat gga aag aaa tgc ctt ttt      930
 Cys Cys Val Glu Ser Leu Pro Asp Lys Asp Gly Lys Lys Cys Leu Phe
 260                 265                 270                 275

 ctc gta aaa tgt ttt gat aag act ttt gaa atc agt gct tca gat aag      978
 Leu Val Lys Cys Phe Asp Lys Thr Phe Glu Ile Ser Ala Ser Asp Lys
                 280                 285                 290

 aag aag aaa cag gag tgg att caa gcc att cat tct act att cat ctg     1026
 Lys Lys Lys Gln Glu Trp Ile Gln Ala Ile His Ser Thr Ile His Leu
             295                 300                 305

 ttg aag ctg ggc agc cct cca cca cac aaa gaa gcc cgc cag cgt cgg     1074
 Leu Lys Leu Gly Ser Pro Pro Pro His Lys Glu Ala Arg Gln Arg Arg
         310                 315                 320

 aaa gaa ctc cgg aag aag cag ctg gct gaa caa gag gaa ctg gag cga     1122
 Lys Glu Leu Arg Lys Lys Gln Leu Ala Glu Gln Glu Glu Leu Glu Arg
     325                 330                 335

 caa atg aag gaa ctc cag gcc gcc aac gaa agc aag cag cag gag ctg     1170
 Gln Met Lys Glu Leu Gln Ala Ala Asn Glu Ser Lys Gln Gln Glu Leu
 340                 345                 350                 355

 gag gcc gtg cgg aag aaa ctg gag gaa gca gca tct cgt gca gca gaa     1218
 Glu Ala Val Arg Lys Lys Leu Glu Glu Ala Ala Ser Arg Ala Ala Glu
                 360                 365                 370

 gag gaa aag aaa cgc ctt cag act caa gtg gaa ctt cag gcc agg ttc     1266
 Glu Glu Lys Lys Arg Leu Gln Thr Gln Val Glu Leu Gln Ala Arg Phe
             375                 380                 385

 agc aca gag ctg gaa aga gag aag ctt atc aga cag cag atg gaa gaa     1314
 Ser Thr Glu Leu Glu Arg Glu Lys Leu Ile Arg Gln Gln Met Glu Glu
         390                 395                 400

 cag gtt gct caa aag tcc tct gaa ctg gaa cag tat tta cag cga gta     1362
 Gln Val Ala Gln Lys Ser Ser Glu Leu Glu Gln Tyr Leu Gln Arg Val
     405                 410                 415

 cgg gag ctg gaa gac atg tac cta aag ctg cag gag gct ctt gaa gat     1410
 Arg Glu Leu Glu Asp Met Tyr Leu Lys Leu Gln Glu Ala Leu Glu Asp
 420                 425                 430                 435

 gag aga cag gcc cgg caa gat gaa gag aca gtg cgg aag ctt cag gcc     1458
 Glu Arg Gln Ala Arg Gln Asp Glu Glu Thr Val Arg Lys Leu Gln Ala
                 440                 445                 450

 agg ttg ttg gag gaa gag tct tcc aag agg gct gaa cta gaa aag tgg     1506
 Arg Leu Leu Glu Glu Glu Ser Ser Lys Arg Ala Glu Leu Glu Lys Trp
             455                 460                 465

 cac ttg gag cag cag cag gcc att cag aca acc gag gcg gag aag cag     1554
 His Leu Glu Gln Gln Gln Ala Ile Gln Thr Thr Glu Ala Glu Lys Gln
         470                 475                 480

 gag ttg gag aat cag cgt gtc ctg aag gaa cag gcc ctg cag gag gcc     1602
 Glu Leu Glu Asn Gln Arg Val Leu Lys Glu Gln Ala Leu Gln Glu Ala
     485                 490                 495

 atg gag cag ctg gag gag ctt gag tta gaa cgg aag caa gca ctt gag     1650
 Met Glu Gln Leu Glu Glu Leu Glu Leu Glu Arg Lys Gln Ala Leu Glu
 500                 505                 510                 515

 cag tac gag gaa gtt aaa aag aag ctg gag atg gca act aat aag acc     1698
 Gln Tyr Glu Glu Val Lys Lys Lys Leu Glu Met Ala Thr Asn Lys Thr
                 520                 525                 530

 aag agc tgg aag gac aaa gtg gcc cat cat gaa gga tta att cga ctg     1746
 Lys Ser Trp Lys Asp Lys Val Ala His His Glu Gly Leu Ile Arg Leu
             535                 540                 545

 ata gaa cca ggt tca aag aac cct cac ctg atc act aac tgg gga cct     1794
 Ile Glu Pro Gly Ser Lys Asn Pro His Leu Ile Thr Asn Trp Gly Pro
         550                 555                 560

 gca gct ttc act gag gca gaa ctt gaa gag aga gag aag aac tgg aaa     1842
 Ala Ala Phe Thr Glu Ala Glu Leu Glu Glu Arg Glu Lys Asn Trp Lys
     565                 570                 575

 gag aaa aag acc acg gag tgactg agcttgctgg cagtcacgtc agttatgtag     1896
 Glu Lys Lys Thr Thr Glu 
 580                 585

 atactgcatg gcaggagagc tttacgctaa agacaaaaga aacagctttg ggggccgggc   1956

 gtggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggtg gatcacctga   2016

 ggtcaggagt tcaagaccag cctggccaac ctggtgaaac cctgtctcta ctaaaaatac   2076

 aaaaaaaatt agctgagcgt ggtggcgggc gcctgtaatc ccagctactt gggaggctga   2136

 ggcaggagaa tcacttgaac gtgggaggcg gaggttgcag cgagctgaga tcatgccgtt   2196

 gtactccagc ttgggcaaca gagtgagact ccatctcaaa acaaaacaaa acaaaacaaa   2256

 acaaaaaaac ccggctttgc tgcttttaac tcttcttcct tctgtgcctc tctaagtggg   2316

 tcagtatcct aaggaagcct tcttatttat cttcctgcaa acaagggtta cctgaaaaga   2376

 aaaaaaaagt caacattgtc aagctgtttg tttactcttt ctttgaaaac atcaccttct   2436

 gaaatttgtc ttttagctct ctcagattct tccccaaatg aggcagggtg cagacagcac   2496

 agtcagctct gcagagtttg gaggggctca ctgccactgg gtactcagaa cctctgtgga   2556

 ctggatgtca gctctttcct ttggcagcgt gtttcctttt ccgagtatgt gctgttaaac   2616

 tagattggcc ggttcgcttt ccatttcctg acacttgaca tggaatgcct ttgaccattg   2676

 gtgctctgac agagaagtca tggagtcatt gccatttcct ggttgccctt ttggaatgtg   2736

 atcctgttag tagaggtttt ctagcttcta ctaagatatt tctttcccta accatcatac   2796

 acttggcatg tttcattccc atctcctttc ccctcacctt aaaggagact acccctttgc   2856

 cccatattgt caacctaatt ttctctcgta ctctctctag tgaatgatgt gctaccaagt   2916

 atatgccagg ctgtgagagg attatactga gtagtagaaa gaagctaatt tgaaataaaa   2976

 attatttgta taattaagaa agcagattag atgcacatgg tcaacaggaa gttgactgta   3036

 tgtctgctag ttagattcaa aacatcataa agatgatagc atgtcaatat attagcctag   3096

 ccattatgtt agcctttgtt aggtgggcag cttttctgct ttttcccttc ctctgtggtg   3156

 acaacggagg aaatatccaa cagaaatacg tctaacaggg aaattgggat catagtttat   3216

 atgcatctga tttgaaagga gtattgagga aggttttcat atatgatcta tctttggatt   3276

 aaaaagaaca tttatgaaat caagccttct aacactagtt ataattgaga agcaacagta   3336

 actccgtgga cagcaatcaa gcttaaaatt gtaaataaat atggggataa ttcagttgtt   3396

 gcaaaaaaag ggcagaattc agtagaataa agtccttttc tcttacaggt attaaatgag   3456

 gacagagaac ctcaggtgtt cttatgctag tgcttgctga gtgcatacta agaaagcaat   3516

 tccaaataga tgtatacatc tagagagagt ggtattagag attcagtgta tgtatttatt   3576

 tacatgagag gaaactggaa tataatccca taaattattg gaatataatc ccataaatta   3636

 tcacctttta tgactggaaa atatttgcca atgaagaaat ggtctgtagg tatttgtctt   3696

 aagatttttg gctgtttaat aaaaatgtaa ctttaacggt ttcttatagt tgcctttata   3756

 aagtgtattg tctaaaatat ttttgtatca tgtgcctttg aaatttgaca gctgatttgg   3816

 gtgttggatt tctgcccagc catttatcag tattatcatt ttattcagta gctggcaggt   3876

 gtattagaca aacgagactt aggtaaggaa tggaaccttt cctgtggttt gactgcacat   3936

 cacaccagaa gactccagta tccctcattc cagaatgagg aaaaagtatt ctacaaagaa   3996

 cctaatcacc tctgtgaaat ctatgggatg gaaacagtgt ggccttagga gtcaaatagt   4056

 ctctgcatgg tggggaggat catgatggaa tatgtgaatt tctacttcta gaagttgtga   4116

 aataggtcct gcacttttgc agaatgtcct tctttaaacc tggcttattc cacagctgta   4176

 gcctgataac atgacctggg gccttagctg ctctagccct gggttcttgg agacctcaca   4236

 ctgcctggcc cctggccatc cacctaagga ctgcctgctt tctggtcaca tgtggacctt   4296

 gatacgacta agcggttaca tatgtggttg tgcaaaagct ttctgtttaa tgcatagtgt   4356

 taccgattta catcttggtt ttcagtggca ctatgtctag gaggcaatat ccttttaaac   4416

 agtgctttgg ctaagataga tacttgtgaa tcaaagatag cacagaaatg aactaagtat   4476

 atcccatttg gaattatatt ttgatactat ttaaaatggt ttcacctgtt aaagggccaa   4536

 cagaactctt ggttttactt ttgtaattac tgtacagaaa atttcaagag tgtttgagtg   4596

 cttgtcatca ggtgttttcc ttaataagta gggatatgat catttacagg aattatatat   4656

 gaaaaaagtt tttgaaatgt atttttgtga tgtgctatgt tgaggggaaa ccaaatattt   4716

 atgattttaa aacattcgta tgaaaacatt gtacaatgta atatgctcaa ctttctcaat   4776

 tttttgctaa tttttctaag atacattaaa aatgttttat attttttttt aagtaaaatg   4836

 gacccagtaa gaaaattaaa aataccagaa catacactta aaaaaaaaa               4885




      <210> 82
      <211> 4936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (238)..(3339)

      <400> 82
 tttcgtggac actgggcttc tgtgtgccag tcgcagccgt tggctggcgg tcacccaatc     60

 ccagggcatg ccgccggagc ctggccagga cgcacggtga aagacgagtt tggtggcagg    120

 cttgaccccc cggctgccag cagaagccgg cgtcgggagc ccaggcgggc aggccgctgg    180

 ggtcggggct gcacgtacga gagccgggac gcccgggttc agagcgaagg aggaggc       237                                                                 
 atg gct tcg gtg ttc atg tgt ggc gtg gag gac ctg ctg ttc agc ggc      285
 Met Ala Ser Val Phe Met Cys Gly Val Glu Asp Leu Leu Phe Ser Gly
   1               5                  10                  15

 agc cgc ttc gta tgg aac ttg acc gtg tcc acg ctg cgg aga tgg tac      333
 Ser Arg Phe Val Trp Asn Leu Thr Val Ser Thr Leu Arg Arg Trp Tyr
              20                  25                  30

 acg gag agg ctg cgg gct tgc cac cag gtg ctg cgg acg tgg tgc ggg      381
 Thr Glu Arg Leu Arg Ala Cys His Gln Val Leu Arg Thr Trp Cys Gly
          35                  40                  45

 ctg cag gac gtg tac cag atg aca gaa ggc agg cac tgc cag gtg cac      429
 Leu Gln Asp Val Tyr Gln Met Thr Glu Gly Arg His Cys Gln Val His
      50                  55                  60

 ctc ctg gat gat agg aga ctg gag ctg ctg gtt cag ccc aaa ctt cta      477
 Leu Leu Asp Asp Arg Arg Leu Glu Leu Leu Val Gln Pro Lys Leu Leu
  65                  70                  75                  80

 gca aga gag ttg ctg gac cta gtg gct tca cat ttc aac ctg aaa gaa      525
 Ala Arg Glu Leu Leu Asp Leu Val Ala Ser His Phe Asn Leu Lys Glu
                  85                  90                  95

 aag gag tat ttt gga ata aca ttc ata gat gac aca ggt cag cag aac      573
 Lys Glu Tyr Phe Gly Ile Thr Phe Ile Asp Asp Thr Gly Gln Gln Asn
             100                 105                 110

 tgg ctg cag tta gat cac cga gtt ctt gac cac gat ttg ccc aag aaa      621
 Trp Leu Gln Leu Asp His Arg Val Leu Asp His Asp Leu Pro Lys Lys
         115                 120                 125

 cca ggc cca acc att ttg cac ttt gct gtg agg ttt tac att gag agc      669
 Pro Gly Pro Thr Ile Leu His Phe Ala Val Arg Phe Tyr Ile Glu Ser
     130                 135                 140

 ata tcg ttt tta aag gat aaa acc acc gtg gag ctg ttt ttc ctg aat      717
 Ile Ser Phe Leu Lys Asp Lys Thr Thr Val Glu Leu Phe Phe Leu Asn
 145                 150                 155                 160

 gca aag gcc tgt gtg cac aag ggg caa atc gaa gta gag agc gaa acc      765
 Ala Lys Ala Cys Val His Lys Gly Gln Ile Glu Val Glu Ser Glu Thr
                 165                 170                 175

 atc ttc aag tta gca gcg ttt att tta cag gaa gcc aag gga gat tat      813
 Ile Phe Lys Leu Ala Ala Phe Ile Leu Gln Glu Ala Lys Gly Asp Tyr
             180                 185                 190

 acc agt gat gaa aat gcc agg aaa gat tta aag aca tta cca gcc ttt      861
 Thr Ser Asp Glu Asn Ala Arg Lys Asp Leu Lys Thr Leu Pro Ala Phe
         195                 200                 205

 cca acc aaa act ctt cag gag cat cca tcc ctt gcc tac tgt gag gac      909
 Pro Thr Lys Thr Leu Gln Glu His Pro Ser Leu Ala Tyr Cys Glu Asp
     210                 215                 220

 agg gta att gag cat tat ttg aaa atc aaa ggt ctc act cga ggt caa      957
 Arg Val Ile Glu His Tyr Leu Lys Ile Lys Gly Leu Thr Arg Gly Gln
 225                 230                 235                 240

 gct gtg gtt cag tat atg aaa ata gta gaa gct cta ccg act tac ggt     1005
 Ala Val Val Gln Tyr Met Lys Ile Val Glu Ala Leu Pro Thr Tyr Gly
                 245                 250                 255

 gtc cat tat tat gca gta aag gat aag caa gga ctt cct tgg tgg ctt     1053
 Val His Tyr Tyr Ala Val Lys Asp Lys Gln Gly Leu Pro Trp Trp Leu
             260                 265                 270

 gga ata agc tat aag gga att ggc caa tat gat ata caa gac aag gtg     1101
 Gly Ile Ser Tyr Lys Gly Ile Gly Gln Tyr Asp Ile Gln Asp Lys Val
         275                 280                 285

 aag cct cgg aag tta ttc caa tgg aaa cag ctg gag aac tta tat ttc     1149
 Lys Pro Arg Lys Leu Phe Gln Trp Lys Gln Leu Glu Asn Leu Tyr Phe
     290                 295                 300

 cgt gag aaa aaa ttt gct gtt gaa gtt cat gat cca cga agg att tca     1197
 Arg Glu Lys Lys Phe Ala Val Glu Val His Asp Pro Arg Arg Ile Ser
 305                 310                 315                 320

 gtt tca aga aga acc ttt ggg caa agt ggc ctg ttt gtg caa aca tgg     1245
 Val Ser Arg Arg Thr Phe Gly Gln Ser Gly Leu Phe Val Gln Thr Trp
                 325                 330                 335

 tat gct aac tct tct ctc atc aag tcc att tgg gta atg gca att agt     1293
 Tyr Ala Asn Ser Ser Leu Ile Lys Ser Ile Trp Val Met Ala Ile Ser
             340                 345                 350

 cag cat cag ttt tac ttg gac cgg aag caa agc aaa gca aaa att cct     1341
 Gln His Gln Phe Tyr Leu Asp Arg Lys Gln Ser Lys Ala Lys Ile Pro
         355                 360                 365

 tca gcc agg agt tta gat gag att gca atg gat ttg aca gag aca gga     1389
 Ser Ala Arg Ser Leu Asp Glu Ile Ala Met Asp Leu Thr Glu Thr Gly
     370                 375                 380

 aca caa agg gcc tcc aag ctg gtg aca ctg gag gcg aaa agt cag ttc     1437
 Thr Gln Arg Ala Ser Lys Leu Val Thr Leu Glu Ala Lys Ser Gln Phe
 385                 390                 395                 400

 atc atg gca agt aat ggc agt tta atc tcc tca ggt tct caa gac tca     1485
 Ile Met Ala Ser Asn Gly Ser Leu Ile Ser Ser Gly Ser Gln Asp Ser
                 405                 410                 415

 gaa gtt agt gaa gag caa aag aga gaa aaa atc ctt gaa cta aag aag     1533
 Glu Val Ser Glu Glu Gln Lys Arg Glu Lys Ile Leu Glu Leu Lys Lys
             420                 425                 430

 aag gag aaa cta tta caa gaa aaa ctt ctg aaa aaa gtt gag gag ctt     1581
 Lys Glu Lys Leu Leu Gln Glu Lys Leu Leu Lys Lys Val Glu Glu Leu
         435                 440                 445

 aag aag atc tgt ctg cgg gag gct gag ctc aca ggc aaa atg cca aag     1629
 Lys Lys Ile Cys Leu Arg Glu Ala Glu Leu Thr Gly Lys Met Pro Lys
     450                 455                 460

 gag tat ccc ctg aac ata ggc gag aag cct cct cag gtc aga aga cgt     1677
 Glu Tyr Pro Leu Asn Ile Gly Glu Lys Pro Pro Gln Val Arg Arg Arg
 465                 470                 475                 480

 gtg ggt act gcg ttc aaa tta gat gac aac ttg ctg ccg agt gaa gaa     1725
 Val Gly Thr Ala Phe Lys Leu Asp Asp Asn Leu Leu Pro Ser Glu Glu
                 485                 490                 495

 gat cct gct ttg caa gaa ctg gag agt aat ttt cta ata caa caa aag     1773
 Asp Pro Ala Leu Gln Glu Leu Glu Ser Asn Phe Leu Ile Gln Gln Lys
             500                 505                 510

 ctg gtg gaa gct gca aag aaa ctt gcc aat gag cca gac ctt tgt aaa     1821
 Leu Val Glu Ala Ala Lys Lys Leu Ala Asn Glu Pro Asp Leu Cys Lys
         515                 520                 525

 act gtg aag aaa aag cga aag caa gat tac aca gat gcg atg aaa aag     1869
 Thr Val Lys Lys Lys Arg Lys Gln Asp Tyr Thr Asp Ala Met Lys Lys
     530                 535                 540

 ctt cag gag att gaa aat gca ata aac gaa tac cga att agg tgt gga     1917
 Leu Gln Glu Ile Glu Asn Ala Ile Asn Glu Tyr Arg Ile Arg Cys Gly
 545                 550                 555                 560

 aag aaa ccc agc cag aaa gca aca gtg tta cca gaa gac ata atc ccc     1965
 Lys Lys Pro Ser Gln Lys Ala Thr Val Leu Pro Glu Asp Ile Ile Pro
                 565                 570                 575

 tca gag agt agc tct ttg tct gac acc acc acc tat gat gat ccc agt     2013
 Ser Glu Ser Ser Ser Leu Ser Asp Thr Thr Thr Tyr Asp Asp Pro Ser
             580                 585                 590

 gat gcc ttc act ttt cct ggg cag cga tca agt tca gta cct cat tct     2061
 Asp Ala Phe Thr Phe Pro Gly Gln Arg Ser Ser Ser Val Pro His Ser
         595                 600                 605

 cca aga att ctt ccc ccc aag tct ctt ggt att gag cga atc cat ttc     2109
 Pro Arg Ile Leu Pro Pro Lys Ser Leu Gly Ile Glu Arg Ile His Phe
     610                 615                 620

 aga aag tcg tcc atc aat gaa cag ttt gtg gat acc agg cag tcc aga     2157
 Arg Lys Ser Ser Ile Asn Glu Gln Phe Val Asp Thr Arg Gln Ser Arg
 625                 630                 635                 640

 gaa atg ctg tcc aca cac agc agc cct tac aaa act ctg gag agg cgg     2205
 Glu Met Leu Ser Thr His Ser Ser Pro Tyr Lys Thr Leu Glu Arg Arg
                 645                 650                 655

 ccc cag gga gga cga agc atg ccc acc acg cca gtt ctt acc cga aac     2253
 Pro Gln Gly Gly Arg Ser Met Pro Thr Thr Pro Val Leu Thr Arg Asn
             660                 665                 670

 gcc tac agc agc agc cac ttg gaa ccc gaa tct tca tct cag cac tgc     2301
 Ala Tyr Ser Ser Ser His Leu Glu Pro Glu Ser Ser Ser Gln His Cys
         675                 680                 685

 cgc cag cgg agt gga agc ctg gag tcc cag tcc cat ctg ctc tcc gag     2349
 Arg Gln Arg Ser Gly Ser Leu Glu Ser Gln Ser His Leu Leu Ser Glu
     690                 695                 700

 atg gac agc gat aag cca ttt ttc tcc ctc tcc aaa tcc caa aga agc     2397
 Met Asp Ser Asp Lys Pro Phe Phe Ser Leu Ser Lys Ser Gln Arg Ser
 705                 710                 715                 720

 agc agc aca gaa atc ctc gat gac ggg tct tct tat aca agc caa tca     2445
 Ser Ser Thr Glu Ile Leu Asp Asp Gly Ser Ser Tyr Thr Ser Gln Ser
                 725                 730                 735

 agc aca gag tat tac tgt gtg aca cca gtt acc ggc ccc tat tac acc     2493
 Ser Thr Glu Tyr Tyr Cys Val Thr Pro Val Thr Gly Pro Tyr Tyr Thr
             740                 745                 750

 acc cag acc ctg gac act cgc acc agg ggt cgg agg agg tca aag aaa     2541
 Thr Gln Thr Leu Asp Thr Arg Thr Arg Gly Arg Arg Arg Ser Lys Lys
         755                 760                 765

 cag aat gtt tct act tca aat tca gga agc atg ccc aac cta gca caa     2589
 Gln Asn Val Ser Thr Ser Asn Ser Gly Ser Met Pro Asn Leu Ala Gln
     770                 775                 780

 aag gat agt ttg agg aat ggt gtt tac tca aag agt cag gag cca ccg     2637
 Lys Asp Ser Leu Arg Asn Gly Val Tyr Ser Lys Ser Gln Glu Pro Pro
 785                 790                 795                 800

 tct tcc agt tac tac att gcc ggg tac aca ccc tat gca gag tgt gac     2685
 Ser Ser Ser Tyr Tyr Ile Ala Gly Tyr Thr Pro Tyr Ala Glu Cys Asp
                 805                 810                 815

 ttt tat tac agt ggt ggt tat gtc tat gag aat gac acc gag gga cag     2733
 Phe Tyr Tyr Ser Gly Gly Tyr Val Tyr Glu Asn Asp Thr Glu Gly Gln
             820                 825                 830

 tat agt gtc aac cct tcc tac cgg tcc tca gcc cac tat gga tat gag     2781
 Tyr Ser Val Asn Pro Ser Tyr Arg Ser Ser Ala His Tyr Gly Tyr Glu
         835                 840                 845

 cgc cag agg gac tac agc aga tcc ttt cac gaa gat gag gtc gac cgg     2829
 Arg Gln Arg Asp Tyr Ser Arg Ser Phe His Glu Asp Glu Val Asp Arg
     850                 855                 860

 gta ccc cat aac cca tat gca act ctc cgg ctg cca agg aag gct gct     2877
 Val Pro His Asn Pro Tyr Ala Thr Leu Arg Leu Pro Arg Lys Ala Ala
 865                 870                 875                 880

 gca aaa tcg gag cac atc acc aaa aac atc cac aag gcc tta gtt gcc     2925
 Ala Lys Ser Glu His Ile Thr Lys Asn Ile His Lys Ala Leu Val Ala
                 885                 890                 895

 gag cac ttg cgt ggc tgg tac cag cgg gcc tct ggg cag aag gat cag     2973
 Glu His Leu Arg Gly Trp Tyr Gln Arg Ala Ser Gly Gln Lys Asp Gln
             900                 905                 910

 gga cac agc ccg cag acc agc ttt gac tca gac agg gga tca cag aga     3021
 Gly His Ser Pro Gln Thr Ser Phe Asp Ser Asp Arg Gly Ser Gln Arg
         915                 920                 925

 tgc ctg ggg ttt gcg ggg ctg caa gta cct tgt tct cca agc agt cgt     3069
 Cys Leu Gly Phe Ala Gly Leu Gln Val Pro Cys Ser Pro Ser Ser Arg
     930                 935                 940

 gca tcc ttg tac tct tca gtg tct tct aca aat gct tct ggg aac tgg     3117
 Ala Ser Leu Tyr Ser Ser Val Ser Ser Thr Asn Ala Ser Gly Asn Trp
 945                 950                 955                 960

 agg acc cag tta acc ata ggg ctg tcg gat tac gag act cca gca cat     3165
 Arg Thr Gln Leu Thr Ile Gly Leu Ser Asp Tyr Glu Thr Pro Ala His
                 965                 970                 975

 tct tct tac acc agc tgc tat ggc aat gtc tat aat cct tta ccc tct     3213
 Ser Ser Tyr Thr Ser Cys Tyr Gly Asn Val Tyr Asn Pro Leu Pro Ser
             980                 985                 990

 cca agc aga caa tac aca gaa atc agt caa ctg gat ggt aca gat gga     3261
 Pro Ser Arg Gln Tyr Thr Glu Ile Ser Gln Leu Asp Gly Thr Asp Gly
         995                1000                1005

 aac cag ctg gaa gac aac ctg gag agt agt gag cag aga ctc ttt tgg     3309
 Asn Gln Leu Glu Asp Asn Leu Glu Ser Ser Glu Gln Arg Leu Phe Trp
    1010                1015                1020

 cat gaa gat tca aag cct gga aca tta gtc t gaactgcagt tggacctcct     3360
 His Glu Asp Ser Lys Pro Gly Thr Leu Val 
1025                1030

 gaccaagcac tgcgttctca cactagtgtg ccttgcaaat tgtatttgtc ttccgagagg   3420

 atgttcgttt tagaaaccta aagacatcaa aggttgaaga gaagacttag ttgccctgga   3480

 agtgaatcag tgaatcacac accaagcccc acaaagcccc taaaggagga tttggccttt   3540

 caaactctag gcactaacgt aactgtaggg tctgcccaca tgttgaagta ttgccaagag   3600

 aggactcagt gtgaagcctt catcaatagc aagcactttt taagggagta aaagttgtta   3660

 aaggcaaacg tcaaaaacat gaaagggcat tcaggatgtc ccatggcaat aagaacaggg   3720

 gaaatctcag agcacaattc agcaggatga gagaagggga accagaagct ccggagtcat   3780

 tgctcacttc agagtttgaa ttcgtgagct gacaaagagt aacatgctct ttctacacag   3840

 acatggacaa tttagacagt attggaaaat tacttgaagc tggattttca tgaagttctg   3900

 aatgagtgta aatgtttttt aggatactat aaagagtgat gtttttcata agcaccataa   3960

 aatgggttct ggaaaaactg attaccttag catcctgtaa tataacttat ggtagcagat   4020

 tggggaaaat gaagcagccc actgaataat tgacaaagtc tgcttggaga acattctaag   4080

 gtacaatatc atggagctcc tttttccttt ctccactaat tgcgtgatga gctattgttc   4140

 tggctggtaa ttctccaact cggctgtcat ttgaagtggc agacttaata tggaaagttt   4200

 ttataattat gagtttgaaa aagcatttta agatgataca gaaagtatcc aaaacaacag   4260

 aaaaaaaaag ccacgtcatt ttagatgaat tgcgtgcctt aaaatggtga acgttagaaa   4320

 attaaacaag tctggattcc acaagtagtt ccaagtcacc aagtgacaaa aacaaggtta   4380

 acattaaaaa agaaaaacaa caacaacgac aaaaagctcc aagctgcagt ggatttaatt   4440

 atgaggctaa aactacctca tactttcctt ggaagaacta attagctatg gtttattgta   4500

 gggttttgtt tgtttgtttt ttaaagcaaa tgatttccat attcctgatt gatctttttt   4560

 gtcatctttg cttcaaaatt acataaaagg tgctcctttc ccccttcttt tatacaagtt   4620

 tcttgttcat attgtgaata gaaaagtttc tgaacaactt ttttggaaca ttttctatct   4680

 atattccaaa gcatgtaata tatacataaa aacgatttgt taaactggtc cttagtcatt   4740

 tgtataatta gaaatgaagt ttgggaaaaa attttggaaa aaagacaagc aaaaaaaaaa   4800

 taacttattc cttttttgca tatttgtata gccttctaga atcagaaata acctttttgc   4860

 atattctttt attgttctga cttttcaaga cctattattt ttttacatag gtcaataaac   4920

 aaaaggtgtg ctactg                                                   4936




      <210> 83
      <211> 661
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(305)

      <400> 83
 catgggaaaa aaggtcatca ataggaactt cccctgaata agccctg  atg ttg aac      56
                                                      Met Leu Asn
                                                        1

 tta gta gac aag tca cct atc tat ctt atc tta tcc tat cta tct atc      104
 Leu Val Asp Lys Ser Pro Ile Tyr Leu Ile Leu Ser Tyr Leu Ser Ile
       5                  10                  15

 tat cta tct atc tat cta tct atc tat cta tct aat cta tct atc tat      152
 Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Ser Asn Leu Ser Ile Tyr
  20                  25                  30                  35

 cta gtt ttg aaa gcg tct cgc tct gtg gcc cag gct gga gta caa tgg      200
 Leu Val Leu Lys Ala Ser Arg Ser Val Ala Gln Ala Gly Val Gln Trp
                  40                  45                  50

 ctc gat cct ggc tca ctg caa cct ccg cct ccc ggg ttc aag caa ttc      248
 Leu Asp Pro Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys Gln Phe
              55                  60                  65

 tcc tgc ctc tgc ctc cca agt agc tgg gat tac agg tgc aca cca cca      296
 Ser Cys Leu Cys Leu Pro Ser Ser Trp Asp Tyr Arg Cys Thr Pro Pro
          70                  75                  80

 cgc ccg gct tagacaa gtactttaaa tcagcttcta cacatatgtt caaataacta      352
 Arg Pro Ala 
      85

 aaggaaactg tgtctacaga attaaagtat gagaatgttt cactaaacaa agaatatgag    412

 taaagataca gaaattatag gagagagcca aatggaagtt tggagtagaa aagtacaata    472

 actgaaatga aaaattcact agagcagctt gacatcaggt tttgtttggc aaaagcatct    532

 gtgaccttga agataggtca actgagatga cccattctga gaagaagaaa aaattccgga    592

 ataaaggaaa gtcaaggagg cctccaaggc tgtgcccagc tccacatcaa cacacgtagc    652

 tggagtcca                                                            661




      <210> 84
      <211> 1784
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (320)..(739)

      <400> 84
 gcaaagccag ctgggctcct gagtccggtg ggtacttgga gaacttacta cgtctagctg     60

 gaggattgta aatgcaccaa tcagcatgct gtgtctagct caagattttc tccatcccct    120

 tattttgggc cagtggctgt cattacatat gagatgagtc tcttgaagac tacagatgaa    180

 ctcaagctcc atgaggagat gtttcattgt cgagagcagt catgatggcc tgcactccac    240

 acaatgcaac agagtgaaag agcaggttct gcttctttgg tgtagtcctg aagcttccta    300

 agaaacttca catcaggtg atg gat agg agc aac cct gta aaa cca gcc tta     352
                      Met Asp Arg Ser Asn Pro Val Lys Pro Ala Leu
                        1               5                  10

 gac tat ttt tca aac agg ctg gtg aat tac cat atc tcc gtc aag tgc      400
 Asp Tyr Phe Ser Asn Arg Leu Val Asn Tyr His Ile Ser Val Lys Cys
              15                  20                  25

 agt aac cag ttc aag ttg gaa gtg tgt ctt ttg aaa tca gag aac aaa      448
 Ser Asn Gln Phe Lys Leu Glu Val Cys Leu Leu Lys Ser Glu Asn Lys
          30                  35                  40

 gtc gtg gac aac cag gct ggg acc cag ggc cag ctg aag gtg ctg ggt      496
 Val Val Asp Asn Gln Ala Gly Thr Gln Gly Gln Leu Lys Val Leu Gly
      45                  50                  55

 gcc aac ctc tgg tgg ccg tac ctg atg cac gaa cac ccc gcc tac ctg      544
 Ala Asn Leu Trp Trp Pro Tyr Leu Met His Glu His Pro Ala Tyr Leu
  60                  65                  70                  75

 tac tcc tgg gag gat ggt gat tgc tca cac caa agc ctt gga ccc ctc      592
 Tyr Ser Trp Glu Asp Gly Asp Cys Ser His Gln Ser Leu Gly Pro Leu
                  80                  85                  90

 cca gcc tgt gac ctt tgg gac caa ctc cac cta cgc agc aga caa ggg      640
 Pro Ala Cys Asp Leu Trp Asp Gln Leu His Leu Arg Ser Arg Gln Gly
              95                 100                 105

 ggc tct gta tgt gga tgt gat ccg tgt gaa cag cta cta ctc ttg gta      688
 Gly Ser Val Cys Gly Cys Asp Pro Cys Glu Gln Leu Leu Leu Leu Val
         110                 115                 120

 tcg caa cta cgg gca cct gga gtt gat tcg gct gca gct ggc cgc cca      736
 Ser Gln Leu Arg Ala Pro Gly Val Asp Ser Ala Ala Ala Gly Arg Pro
     125                 130                 135

 gtt tgag aattggtgtg agacatcaca atcccattat tcagagcgcg tatggagtgg      793
 Val 
 140

 aaacgcttgt agggtttcac cagggctggt gaattaccag atctccgtca agtgcagtaa    853

 ccagttcaag ttggaagtat gtcttttgaa tgcagaaaac aaagtcgtgg acaaccaggc    913

 tgggacccag ggccagctga aggtgctggt gccaacctct ggtggccgta cctgatgcac    973

 gaacaccccg cctacctgta ctcgtgggag gatggtgatt gctcacacca aagccttgga   1033

 cccctcccag cctgtgacct ttgggaccaa ctccacctac gcagcagaca agggggctct   1093

 gtatgtggat gtgatccgtg tgaacagcta ctactcttgg tatcgcaact acgggcacct   1153

 ggagttgatt cggctgcagg ccctgcagct ggccgcccag tttgtgaatt ggtgtaagac   1213

 atcacaatcc cattattcag agcgcgtatg gagtggaaac gcttgtaggg tttcaccagt   1273

 ctttcccagg gaactccgat gaagtgttcc aacaaaatga gcgagtgaac caagaagagg   1333

 atgacattag atccaggaga tacaacagag gagataatct ccaggatgcc tgtgaagaaa   1393

 gatccctgga tcccaggatg attataggac aagttgttca taatccagca ggccagaaga   1453

 cttccaggga aactcatttc aagatgaaaa tggaccagcc gcagtggctc acgcctgtaa   1513

 taccagcact ttgggaggct gaggcgggcg gatcacttga ggtcaagagt ttgaaactag   1573

 cctggccaac gtggcaaaac tccatctcta ttaaagatac aaaaattagc caggcatagt   1633

 ggtgcatgcc tgtagtccca gctacttggg atgctgaggc aggaagaatt gcttgaacct   1693

 gggaggcaga gtctgcggtg accgagatca tgccactgca ctccagcctg ggtgacagag   1753

 ccagactccg tctctactaa aaaaaaaaaa a                                  1784




      <210> 85
      <211> 2150
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (970)..(1110)

      <400> 85
 gaaccataac ctatactacc tatcaatact catcattaat aatcataatg gctatagcaa     60

 taaaactagg aatagccccc tttcacttct gagtcccaga ggttacccaa ggcacccctc    120

 tgacatccgg cctgcttctt ctcacatgac aaaaactagc ccccatctca atcatatacc    180

 aaatctctgc cctcactata cgtaagcctt ctcctcactc tctcaatctt atccatcata    240

 agcaggcagt tgaggtggat ttaacctaac ccagctacgc caaatcttag catactccgt    300

 caattaccca cataggatga ataatagcag gtgtctaccg tacaacccta acataaccat    360

 tcttaattta actatttata ttatcctaac tactaccgca tgtccgtacg tatttcaacc    420

 tttaaacgtc cagcaccacg accctactac tatctcgcac ctgaaacaag ctaacatgac    480

 taacaccctt aattccatcc accctcctct ccctaggagg cctgcccccg ctaaccggct    540

 ttttgcccaa atgggccatt atcgaagaat tcacaaaaaa caatagcctc atcatcccca    600

 ccatcatagc caccatcacc ctccttaacc tctacttcta cctacgccta atctactcca    660

 cctcaatcac actactcccc atatctaaca acgtaaaaat aaaatgacag tttgaacata    720

 caaaacccac cccattcctc cccacactca tcgcccttac cacgctactc ccacctatca    780

 caccccatcc taaagtaagg tcagctaaat aagctatcgg gcccataccc cgaaaatgtt    840

 ggttataccc ttcccgtact aattaatccc ctggcccaac ccgtcatcta ctctaccatc    900

 tttgcaggca cactcatcac agcgctaagc tcgcactgat tttttacctg agtaggccta    960

 gaaataaac    atg cta gct ttt att cca gtt cta acc aaa aaa ata aac    1008
              Met Leu Ala Phe Ile Pro Val Leu Thr Lys Lys Ile Asn
                1               5                  10

 cct cgt tcc aca gaa gct gcc atc aag tat ttc ctc acg caa gca acc     1056
 Pro Arg Ser Thr Glu Ala Ala Ile Lys Tyr Phe Leu Thr Gln Ala Thr
      15                  20                  25

 gca tcc ata atc ctt cta ata gct atc ctc ttc aac aat ata ctc tcc     1104
 Ala Ser Ile Ile Leu Leu Ile Ala Ile Leu Phe Asn Asn Ile Leu Ser
  30                  35                  40                  45

 gga caa tgaaccataa ccaatactac caatcaatac tcatcattaa taatcataat      1160
 Gly Gln 


 ggctatagca ataaaactag gaatagcccc ctttcacttc tgagtcccag aggttaccca   1220

 aggcacccct ctgacatccg gcctgcttct tctcacatga caaaaactag cccccatctc   1280

 aatcatatac caaatctctc cctcactaaa cgtaagcctt ctcctcactc tctcaatctt   1340

 atccatcata gcaggcagtt gaggtggatt aaaccaaacc cagctacgca aaatcttagc   1400

 atactcctca attacccaca taggatgaat aatagcagtt ctaccgtaca accctaacat   1460

 aaccattctt aatttaacta tttatattat cctaactact accgcattcc tactactcaa   1520

 cttaaactcc agcaccacga ccctactact atctcgcacc tgaaacaagc taacatgact   1580

 aacaccctta attccatcca ccctcctctc cctaggaggc ctgcccccgc taaccggctt   1640

 tttgcccaaa tgggccatta tcgaagaatt cacaaaaaac aatagcctca tcatccccac   1700

 catcatagcc accatcaccc tccttaacct ctacttctac ctacgcctaa tctactccac   1760

 ctcaatcaca ctactcccca tatctaacaa cgtaaaaata aaatgacagt ttgaacatac   1820

 aaaacccacc ccattcctcc ccacactcat cgcccttacc acgctactcc tacctatctc   1880

 cccttttaat cgcaatggca ttcctaatgc ttaccgaacg aaaaattcta ggctatatac   1940

 aactacgcaa aggccccaac gttgtaggcc cctacgggct actacaaccc ttcgctgacg   2000

 ccataaaact cttcaccaaa gagcccctaa aacccgccac atctaccatc accctctaca   2060

 tcaccgcccc gaccttagct ctcaccatcg ctcttctact atgaaccccc ctccccatac   2120

 ccaaccccct ggtcaacctc aacctaaggc                                    2150




      <210> 86
      <211> 1184
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (461)..(655)

      <400> 86
 gaagcagccg gaaaaaaatg ctggtcccac agccaggaca tcagccacag tgccggtcct     60

 gtgcctcctg gccatcatct tcatcctcac cgcagccctt tcctatgtgc tgtgcaagag    120

 gaggaggggg cagtcaccgc agtcctctcc agatctgccg gttcattata tacctgtggc    180

 acctgactct aatacctgag ccaagaatgg aagtttgtga ggagacggac tctatgttgc    240

 ccaggctgtt atggaactcc tgagtcaagt gatcctccca ccttggcctc tgaaggtgcg    300

 aggattatag gcgtcaccta ccacatccag cctacacgta tttgttaata tctaacatag    360

 gactaaccag ccactgccct ctcttaggcc cctcatttaa aaacggttat actataaaat    420

 ctgcttttca cactgggtga taataacttg gacaaattct  atg tgt att ttg ttt     475
                                              Met Cys Ile Leu Phe
                                                1               5

 tgt ttt gct ttg ctt tgt ttt gag acg gag tct cgc tct gtc atc cag      523
 Cys Phe Ala Leu Leu Cys Phe Glu Thr Glu Ser Arg Ser Val Ile Gln
                  10                  15                  20

 gct gga gtg cag tgg cat gat ctc ggc tca ctg caa ccc cca tct ccc      571
 Ala Gly Val Gln Trp His Asp Leu Gly Ser Leu Gln Pro Pro Ser Pro
              25                  30                  35

 agg ttc aag cga ttc tcc tgc ctc ctc cta agt agc tgg gac tac agg      619
 Arg Phe Lys Arg Phe Ser Cys Leu Leu Leu Ser Ser Trp Asp Tyr Arg
          40                  45                  50

 tgc tca cca cca cac ccg gct aat ttt ttg tat ttt tagt agagaccggg      669
 Cys Ser Pro Pro His Pro Ala Asn Phe Leu Tyr Phe 
      55                  60                  65

 gtttcaccat gttgaccagg ctggtctcga actcctgacc tggtgatctg cccacccagg    729

 cctcccaaag tgctgggatt aaaggtgtga gccaccatgc ctggccctat gtgtgttttt    789

 taactactaa aaattatttt tgtaatgatt gagtcttctt tatggaaaca actggcctca    849

 gcccttgcgc ccttactgtg attcctggct tcattttttg ctgatggttc cccctcgtcc    909

 caaatctctc tcccagtaca ccagttgttc ctcccccacc tcagccctct cctgcatcct    969

 cctgtacccg caacgaaggc ctgggctttc ccaccctccc tccttagcag gtgccgtgct   1029

 gggacaccat acgggttggt ttcacctcct cagtcccttg cctaccccag tgagagtctg   1089

 atcttgtttt tattgttatt gcttttatta ttattgcttt tattatcatt aaaactctag   1149

 ttcttgtttt gtctctccga atgaaaaaaa aaaaa                              1184




      <210> 87
      <211> 1255
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(944)

      <400> 87
 ggcgagctct cagcggaccg agacggtgca gggccggaga agcaccttca ctcccagcct     60

 gcgccccg atg ctg cgc gtt ctg tgc ctc ctg cgc ccc tgg agg ccc ctt     110
          Met Leu Arg Val Leu Cys Leu Leu Arg Pro Trp Arg Pro Leu
            1               5                  10

 cgg gcc cgc ggc tgc gct tcc gac ggg gcg gcc ggg ggc tca gag atc      158
 Arg Ala Arg Gly Cys Ala Ser Asp Gly Ala Ala Gly Gly Ser Glu Ile
  15                  20                  25                  30

 caa gtg cgc gcc ctg gcg ggt ccg gac caa ggg atc act gag att ctg      206
 Gln Val Arg Ala Leu Ala Gly Pro Asp Gln Gly Ile Thr Glu Ile Leu
                  35                  40                  45

 atg aac aga cct tct gcc cgc aat gcc ttg ggg aat gtc ttc gtc agt      254
 Met Asn Arg Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser
              50                  55                  60

 gag ctg ctg gaa act ctg gcc cag ctg cgg gag gac cgg caa gtg cgt      302
 Glu Leu Leu Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg
          65                  70                  75

 gtc ctg ctc ttc aga agt gga gtg aag ggc gtg ttc tgt gca ggt gca      350
 Val Leu Leu Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala
      80                  85                  90

 gac ctg aag gag cgg gaa cag atg agt gaa gca gag gtg ggg gtg ttt      398
 Asp Leu Lys Glu Arg Glu Gln Met Ser Glu Ala Glu Val Gly Val Phe
  95                 100                 105                 110

 gtc cag cga ctc cgg ggc ctg atg aat gac atc gca gcc ttc cct gca      446
 Val Gln Arg Leu Arg Gly Leu Met Asn Asp Ile Ala Ala Phe Pro Ala
                 115                 120                 125

 ccc acc att gcg gct atg gat ggg ttt gcc ttg ggc gga ggc cta gag      494
 Pro Thr Ile Ala Ala Met Asp Gly Phe Ala Leu Gly Gly Gly Leu Glu
             130                 135                 140

 ctt gcc ctg gcc tgt gac ctc cga gtg gca gct tcc tcg gca gtc atg      542
 Leu Ala Leu Ala Cys Asp Leu Arg Val Ala Ala Ser Ser Ala Val Met
         145                 150                 155

 gga ctg att gag acc acg cga ggg ctc ctc ccg ggg gca gga ggg act      590
 Gly Leu Ile Glu Thr Thr Arg Gly Leu Leu Pro Gly Ala Gly Gly Thr
     160                 165                 170

 cag agg ctg ccc cgt tgt ctg ggg gtg gcc ctg gcg aag gag ctc atc      638
 Gln Arg Leu Pro Arg Cys Leu Gly Val Ala Leu Ala Lys Glu Leu Ile
 175                 180                 185                 190

 ttc acg ggc cga cga ctg agt gga act gag gcc cac gta ctg ggg ctg      686
 Phe Thr Gly Arg Arg Leu Ser Gly Thr Glu Ala His Val Leu Gly Leu
                 195                 200                 205

 gtg aat cac gct gtg gcc cag aac gag gag ggg gac gcc gcc tac cag      734
 Val Asn His Ala Val Ala Gln Asn Glu Glu Gly Asp Ala Ala Tyr Gln
             210                 215                 220

 cgg gca cga gca ctg gcc cag gag atc ctg ccc cag gcc ccc att gcc      782
 Arg Ala Arg Ala Leu Ala Gln Glu Ile Leu Pro Gln Ala Pro Ile Ala
         225                 230                 235

 gtg cgg ctg ggc aaa gta gcc att gac cga gga acg gag gtg gac att      830
 Val Arg Leu Gly Lys Val Ala Ile Asp Arg Gly Thr Glu Val Asp Ile
     240                 245                 250

 gca tct ggg atg gcc att gaa ggg atg tgc tat gcc cag aat att cca      878
 Ala Ser Gly Met Ala Ile Glu Gly Met Cys Tyr Ala Gln Asn Ile Pro
 255                 260                 265                 270

 acc cgg gac cgg cta gag ggc atg gca gcc ttc agg gag aag cgg act      926
 Thr Arg Asp Arg Leu Glu Gly Met Ala Ala Phe Arg Glu Lys Arg Thr
                 275                 280                 285

 ccc aaa ttt gtt ggc aaa tgaccc ccattttaac cttcagcatg ggagatgcat      980
 Pro Lys Phe Val Gly Lys 
             290

 gccctgaaga gcaggatcca gaaggaagat ttgtggccag attgccttca tcatttcacc   1040

 tctccagact tccatttctt cacaaggatg atgatggaaa taaaatgact ggcgtgatgc   1100

 ctggaaccaa ggtgctgatc ctaccaccta ctgctacctt ccttagcttc accctggcta   1160

 gaaataatca cgagggttgg gtttgctttg gaaaatgcct gtctctctac ttgaatgata   1220

 aagaattaaa ttagatctct ctgaaaaaaa aaaaa                              1255




      <210> 88
      <211> 1207
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(896)

      <400> 88
 ggcgagctct cagcggaccg agacggtgca gggccggaga agcaccttca ctcccagcct     60

 gcgccccg atg ctg cgc gtt ctg tgc ctc ctg cgc ccc tgg agg ccc ctt     110
          Met Leu Arg Val Leu Cys Leu Leu Arg Pro Trp Arg Pro Leu
            1               5                  10

 cgg gcc cgc ggc tgc gct tcc gac ggg gcg gcc ggg ggc tca gag atc      158
 Arg Ala Arg Gly Cys Ala Ser Asp Gly Ala Ala Gly Gly Ser Glu Ile
  15                  20                  25                  30

 caa gtg cgc gcc ctg gcg ggt ccg gac caa ggg atc act gag att ctg      206
 Gln Val Arg Ala Leu Ala Gly Pro Asp Gln Gly Ile Thr Glu Ile Leu
                  35                  40                  45

 atg aac aga cct tct gcc cgc aat gcc ttg ggg aat gtc ttc gtc agt      254
 Met Asn Arg Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser
              50                  55                  60

 gag ctg ctg gaa act ctg gcc cag ctg cgg gag gac cgg caa gtg cgt      302
 Glu Leu Leu Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg
          65                  70                  75

 gtc ctg ctc ttc aga agt gga gtg aag ggc gtg ttc tgt gca ggt gca      350
 Val Leu Leu Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala
      80                  85                  90

 gac ctg aag gag cgg gaa cag atg agt gaa gca gag gtg ggg gtg ttt      398
 Asp Leu Lys Glu Arg Glu Gln Met Ser Glu Ala Glu Val Gly Val Phe
  95                 100                 105                 110

 gtc cag cga ctc cgg ggc ctg atg aat gac atc gca gcc ttc cct gca      446
 Val Gln Arg Leu Arg Gly Leu Met Asn Asp Ile Ala Ala Phe Pro Ala
                 115                 120                 125

 ccc acc att gcg gct atg gat ggg ttt gcc ttg ggc gga ggc cta gag      494
 Pro Thr Ile Ala Ala Met Asp Gly Phe Ala Leu Gly Gly Gly Leu Glu
             130                 135                 140

 ctt gcc ctg gcc tgt gac ctc cga gtg gca gct tcc tcg gca gtc atg      542
 Leu Ala Leu Ala Cys Asp Leu Arg Val Ala Ala Ser Ser Ala Val Met
         145                 150                 155

 gga ctg att gag acc acg cga ggg ctc ctc ccg ggg gca gga ggg act      590
 Gly Leu Ile Glu Thr Thr Arg Gly Leu Leu Pro Gly Ala Gly Gly Thr
     160                 165                 170

 cag agg ctg ccc cgt tgt ctg ggg gtg gcc ctg gcg aag gag ctc atc      638
 Gln Arg Leu Pro Arg Cys Leu Gly Val Ala Leu Ala Lys Glu Leu Ile
 175                 180                 185                 190

 ttc acg ggc cga cga ctg agt gga act gag gcc cac gta ctg ggg ctg      686
 Phe Thr Gly Arg Arg Leu Ser Gly Thr Glu Ala His Val Leu Gly Leu
                 195                 200                 205

 gtg aat cac gct gtg gcc cag aac gag gag ggg gac gcc gcc tac cag      734
 Val Asn His Ala Val Ala Gln Asn Glu Glu Gly Asp Ala Ala Tyr Gln
             210                 215                 220

 cgg gca cga gca ctg gcc cag gag atc ctg ccc cag gcc ccc att gcc      782
 Arg Ala Arg Ala Leu Ala Gln Glu Ile Leu Pro Gln Ala Pro Ile Ala
         225                 230                 235

 gtg cgg ctg ggc aaa gta gcc att gac cga gga acg gag aat att cca      830
 Val Arg Leu Gly Lys Val Ala Ile Asp Arg Gly Thr Glu Asn Ile Pro
     240                 245                 250

 acc cgg gac cgg cta gag ggc atg gca gcc ttc agg gag aag cgg act      878
 Thr Arg Asp Arg Leu Glu Gly Met Ala Ala Phe Arg Glu Lys Arg Thr
 255                 260                 265                 270

 ccc aaa ttt gtt ggc aaa tgaccc ccattttaac cttcagcatg ggagatgcat      932
 Pro Lys Phe Val Gly Lys 
                 275

 gccctgaaga gcaggatcca gaaggaagat ttgtggccag attgccttca tcatttcacc    992

 tctccagact tccatttctt cacaaggatg atgatggaaa taaaatgact ggcgtgatgc   1052

 ctggaaccaa ggtgctgatc ctaccaccta ctgctacctt ccttagcttc accctggcta   1112

 gaaataatca cgagggttgg gtttgctttg gaaaatgcct gtctctctac ttgaatgata   1172

 aagaattaaa ttagatctct ctgaaaaaaa aaaaa                              1207




      <210> 89
      <211> 1162
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(851)

      <400> 89
 ggcgagctct cagcggaccg agacggtgca gggccggaga agcaccttca ctcccagcct     60

 gcgccccg atg ctg cgc gtt ctg tgc ctc ctg cgc ccc tgg agg ccc ctt     110
          Met Leu Arg Val Leu Cys Leu Leu Arg Pro Trp Arg Pro Leu
            1               5                  10

 cgg gcc cgc ggc tgc gct tcc gac ggg gcg gcc ggg ggc tca gag atc      158
 Arg Ala Arg Gly Cys Ala Ser Asp Gly Ala Ala Gly Gly Ser Glu Ile
  15                  20                  25                  30

 caa gtg cgc gcc ctg gcg ggt ccg gac caa ggg atc act gag att ctg      206
 Gln Val Arg Ala Leu Ala Gly Pro Asp Gln Gly Ile Thr Glu Ile Leu
                  35                  40                  45

 atg aac aga cct tct gcc cgc aat gcc ttg ggg aat gtc ttc gtc agt      254
 Met Asn Arg Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser
              50                  55                  60

 gag ctg ctg gaa act ctg gcc cag ctg cgg gag gac cgg caa gtg cgt      302
 Glu Leu Leu Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg
          65                  70                  75

 gtc ctg ctc ttc aga agt gga gtg aag ggc gtg ttc tgt gca ggt gca      350
 Val Leu Leu Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala
      80                  85                  90

 gac ctg aag gag cgg gaa cag atg agt gaa gca gag gtg ggg gtg ttt      398
 Asp Leu Lys Glu Arg Glu Gln Met Ser Glu Ala Glu Val Gly Val Phe
  95                 100                 105                 110

 gtc cag cga ctc cgg ggc ctg atg aat gac atc gct tcc tcg gca gtc      446
 Val Gln Arg Leu Arg Gly Leu Met Asn Asp Ile Ala Ser Ser Ala Val
                 115                 120                 125

 atg gga ctg att gag acc acg cga ggg ctc ctc ccg ggg gca gga ggg      494
 Met Gly Leu Ile Glu Thr Thr Arg Gly Leu Leu Pro Gly Ala Gly Gly
             130                 135                 140

 act cag agg ctg ccc cgt tgt ctg ggg gtg gcc ctg gcg aag gag ctc      542
 Thr Gln Arg Leu Pro Arg Cys Leu Gly Val Ala Leu Ala Lys Glu Leu
         145                 150                 155

 atc ttc acg ggc cga cga ctg agt gga act gag gcc cac gta ctg ggg      590
 Ile Phe Thr Gly Arg Arg Leu Ser Gly Thr Glu Ala His Val Leu Gly
     160                 165                 170

 ctg gtg aat cac gct gtg gcc cag aac gag gag ggg gac gcc gcc tac      638
 Leu Val Asn His Ala Val Ala Gln Asn Glu Glu Gly Asp Ala Ala Tyr
 175                 180                 185                 190

 cag cgg gca cga gca ctg gcc cag gag atc ctg ccc cag gcc ccc att      686
 Gln Arg Ala Arg Ala Leu Ala Gln Glu Ile Leu Pro Gln Ala Pro Ile
                 195                 200                 205

 gcc gtg cgg ctg ggc aaa gta gcc att gac cga gga acg gag gtg gac      734
 Ala Val Arg Leu Gly Lys Val Ala Ile Asp Arg Gly Thr Glu Val Asp
             210                 215                 220

 att gca tct ggg atg gcc att gaa ggg atg tgc tat gcc cag aat att      782
 Ile Ala Ser Gly Met Ala Ile Glu Gly Met Cys Tyr Ala Gln Asn Ile
         225                 230                 235

 cca acc cgg gac cgg cta gag ggc atg gca gcc ttc agg gag aag cgg      830
 Pro Thr Arg Asp Arg Leu Glu Gly Met Ala Ala Phe Arg Glu Lys Arg
     240                 245                 250

 act ccc aaa ttt gtt ggc aaa tg acccccattt taaccttcag catgggagat      883
 Thr Pro Lys Phe Val Gly Lys 
 255                 260

 gcatgccctg aagagcagga tccagaagga agatttgtgg ccagattgcc ttcatcattt    943

 cacctctcca gacttccatt tcttcacaag gatgatgatg gaaataaaat gactggcgtg   1003

 atgcctggaa ccaaggtgct gatcctacca cctactgcta ccttccttag cttcaccctg   1063

 gctagaaata atcacgaggg ttgggtttgc tttggaaaat gcctgtctct ctacttgaat   1123

 gataaagaat taaattagat ctctctgaaa aaaaaaaaa                          1162




      <210> 90
      <211> 3457
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (840)..(1391)

      <400> 90
 ccctagtcag agtggaggaa ttccaggctc aagacagcgc ttccaggttc agtttcaggg     60

 tctcgccggc agccccagcc ggcgggcgcg gagcgggcag cggggcccgg atcgcaggct    120

 cctctggggg ccccggagtt gggaagcggc gtccgggagc ccccggagga ggatgggctg    180

 cagacacagc aggctgagca gctgcaaacc cccgaaaaag aagcgccaag aaccagaacc    240

 agaacagcca cccagaccag agccccatga attaggtccc ctcaatgggg acacagctat    300

 aactgtccag ctctgtgcat cagaggaggc tgagcggcac cagaaggata taaccagaat    360

 tctccagcaa catgaggagg aaaagaagaa atgggcacaa caggtggaga aggaaaggga    420

 gctagagctt cgagacagac tggatgagca gcaaagggtc ctggaaggaa agaatgaaga    480

 ggccctgcaa gtcctccggg cctcatatga acaggagaaa gaagcgctta cccactcttt    540

 ccgggaggcc agttctaccc agcaggagac catagacaga ctgacctcac agctggaggc    600

 tttccaggcc aaaatgaaga gggtggagga gtccattctg agccgaaact ataagaaaca    660

 tatccaggat tatgggagcc ccagccagtt ctgggagcag gagctggaga gcttacactt    720

 tgtcatcgag atgaagaatg agcgtattca tgagctggac aggcggctga tcctcatgga    780

 aacagtgaaa gagaaaaatc tgatattgga ggaaaaaatt acgaccctgc aacaggaaa     839                                                                 
 atg agg acc tcc atg tcc gaa gcc gca acc agg tgg tcc tgt caa ggc      887
 Met Arg Thr Ser Met Ser Glu Ala Ala Thr Arg Trp Ser Cys Gln Gly
   1               5                  10                  15

 agc tgt cag aag acc tgc ttc tca cgc gtg agg ccc tgg aga aag agg      935
 Ser Cys Gln Lys Thr Cys Phe Ser Arg Val Arg Pro Trp Arg Lys Arg
              20                  25                  30

 tgc aac tgc ggc gac agc tcc agc agg aga agg agg agc tgt tgt acc      983
 Cys Asn Cys Gly Asp Ser Ser Ser Arg Arg Arg Arg Ser Cys Cys Thr
          35                  40                  45

 ggg tcc ttg ggg cca atg cct cgc ctg cct tcc ctc tgg ccc ctg tca     1031
 Gly Ser Leu Gly Pro Met Pro Arg Leu Pro Ser Leu Trp Pro Leu Ser
      50                  55                  60

 ctc cca ctg agg tct ctt tcc tcg cca cat agg gtg cag ggc ctg ggc     1079
 Leu Pro Leu Arg Ser Leu Ser Ser Pro His Arg Val Gln Gly Leu Gly
  65                  70                  75                  80

 cca cca cga cgc ctg aag tca cag ctc ctt cca agg ttt ttc tgg aga     1127
 Pro Pro Arg Arg Leu Lys Ser Gln Leu Leu Pro Arg Phe Phe Trp Arg
                  85                  90                  95

 aga cag cag gag cct ctc agt tct ttt cca gga agg aac gag ggt ggg     1175
 Arg Gln Gln Glu Pro Leu Ser Ser Phe Pro Gly Arg Asn Glu Gly Gly
             100                 105                 110

 agc gag atg gag atc ctg ggt gtg tgc cca gtg agc cct ggg gcc ttg     1223
 Ser Glu Met Glu Ile Leu Gly Val Cys Pro Val Ser Pro Gly Ala Leu
         115                 120                 125

 agt tac atg gaa tca ccc aca ggg ttt tgg agg ccc cga gaa gcg tct     1271
 Ser Tyr Met Glu Ser Pro Thr Gly Phe Trp Arg Pro Arg Glu Ala Ser
     130                 135                 140

 tcc ctt gag ttg gcc aag gga ata agc aag agg aga cat ttc ctc cct     1319
 Ser Leu Glu Leu Ala Lys Gly Ile Ser Lys Arg Arg His Phe Leu Pro
 145                 150                 155                 160

 gcc cca gca ctc tgt ccc aat ccg aga agt tcc gag gct ttc cca ggg     1367
 Ala Pro Ala Leu Cys Pro Asn Pro Arg Ser Ser Glu Ala Phe Pro Gly
                 165                 170                 175

 gca gtc tgt gtc acg ctg gcc att tgacataaag gagacagccc ctggtcccag    1421
 Ala Val Cys Val Thr Leu Ala Ile 
             180

 cttgtcagct ctgctgccga cttgctgact tatcaacttc ctctaggtgt ttccactcca   1481

 ccctggcctg ctcagagcct cagtttaccc ctgcattaaa atggtggggg gactggtcaa   1541

 aggactctta tgtcactgca gtgtcccatt ctaggattgt ctgaaggcca gagtaggggt   1601

 tggggggagt gtggacaaac cccgcaaatc agagtgggga aggtgagtgg tagagagggg   1661

 gtctctgaag gcccttgggg ctgacagggc caggcagcct ccccagctga ggcatcattc   1721

 ctgggccaga gtcgtgtcca ccaagggaca gtagccagag ctcctcttcc tttaccaggc   1781

 aaggtgcatc ccctcagccc tcctggccct tcagtcttgg tgccacctgg gcacaggggc   1841

 aagcttggtg gttgtgagtc cattcatcta tcagagctgg aacctcatcc ctgcacagat   1901

 gaggaaacca aggcatggag cagttcccag agtcgaatct agatctcatc tgtcatccgg   1961

 gtcttatcct ttgctctgtt tttctcttca ggctctggaa aatcagatct gtgacttaat   2021

 cttcctctcc ctggccctca cccacttagt ttctttttca ttcctgctcc ctgccttaac   2081

 tcctcctccc actgcccctg atcccaggcc caggctttta caacctggtg ctcagcttcc   2141

 ccatcagtga aaaggggtgg ctagagtaac taacctcagc aggccgtcca gtcctgatag   2201

 tctgtggatt tcggatcctt ctcaggaagc ttcatgtcta atggagacta taattataac   2261

 tcctgttctg catagagcat ttgcatcaaa ggctttccat acccctccct cccctggtcc   2321

 tcataagatc cttgaagcag gttcctattc ctcattggca acatggcaaa cagatcacag   2381

 gagtcaaagg gccttgctca aggtccccag cttcagcccc aggccctaag ccagcgtcag   2441

 aacagtcaat ctgcattttt catcagtcat tctatagtga catcatccca gactgccttc   2501

 tgtattcccc tgtgtacagt ctccttctgt ttctaggttt agaagttcag aggtgactgt   2561

 gtttctccat ttccacagcc aaatggggga agaggtgagg ctaggggagt gctgtgctga   2621

 ttctccagcc atggtcagac aggtcaccca ggagcctcga ggaaagccct ggagggaatc   2681

 acatgtgtac tttttcatga agctttttgc aaagcacatc tgcgatacac tagtttattg   2741

 aactaatgtc caggagtaga cgtgattggt ggccaagtta tttggggaca cctaaacaga   2801

 tcagtgacct gaatgacttc tcagaacctt taatatgcca atgtgtgtgg caaacttaca   2861

 agaagggagc taagtatcca gcctctccca aacctctttg aacaaagctt ctgtccctcc   2921

 cacacctctc acctcacagg cacatcaggc tgcagaatgc gctttagaaa gcattgtttt   2981

 agtccaggca cagtggctca cgcctgtaat cccagcactt tgggaggccg aggtgggtgg   3041

 atcacaaggt tgggagattg agaccatcct ggctaacaca gtgaaaccct gtctctacta   3101

 aaaaaataca aaaaattagc ttggcgtggt ggtgggcgcc tgtagtccca gcagcttggg   3161

 aggctgaggc tggagaatgg tgtgaaccca ggaggcggag cttgcagtga gccaagatcg   3221

 cgccactgca ctccagcccg ggtgacagag caagactccg tctcaaaaaa aagaaaagaa   3281

 aaaagaaagc attgttttaa ttgagagggg cagggctgga gaaggagcaa gttgtgggga   3341

 gccaggcttc cctcacgcag cctgtggtgg atgtgggaag gagatcaact tctcctcact   3401

 ctgggacaga cgatgtatgg aaactaaaaa gaacatgcgg caccttaaaa aaaaaa       3457




      <210> 91
      <211> 1120
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(998)

      <400> 91
 gggggtactg ggaatctgaa accatctgct ctgggaaagg ctgcggcgcg gctcccactc     60

 tcggaacctt gtcctgtttg tcccccagct cggcaagcgc catatgagcc tggcggcgcc    120

 ag   atg cga atc ctg ttg tgg gct ttt tgg cct att ccc tca gtc ttg     167
      Met Arg Ile Leu Leu Trp Ala Phe Trp Pro Ile Pro Ser Val Leu
        1               5                  10                  15

 ccg gga tgg cac cgc ccg cat agg act tcc agg gtt ggg ctg agt ggg      215
 Pro Gly Trp His Arg Pro His Arg Thr Ser Arg Val Gly Leu Ser Gly
                  20                  25                  30

 agt tcg act gct ggg cct cgt aat tct cgc ttt ggg gct gct cct tcc      263
 Ser Ser Thr Ala Gly Pro Arg Asn Ser Arg Phe Gly Ala Ala Pro Ser
              35                  40                  45

 agg ctg gga cac act ggg gcc cgc tgt cgg tct ccc gtc ctc cga cat      311
 Arg Leu Gly His Thr Gly Ala Arg Cys Arg Ser Pro Val Leu Arg His
          50                  55                  60

 ctt gtc tgg aac ttc cgc ctg gca gtc tcc agt agg agt gga gct ctg      359
 Leu Val Trp Asn Phe Arg Leu Ala Val Ser Ser Arg Ser Gly Ala Leu
      65                  70                  75

 tgc ggc gta ttt ggt gga aaa cgg gcc ttg cgt cgg ctc acc cca agt      407
 Cys Gly Val Phe Gly Gly Lys Arg Ala Leu Arg Arg Leu Thr Pro Ser
  80                  85                  90                  95

 tgg ttg tgt ttc aga atg aag act att ctc agc aat cag act gtc gac      455
 Trp Leu Cys Phe Arg Met Lys Thr Ile Leu Ser Asn Gln Thr Val Asp
                 100                 105                 110

 att cca gaa aat gtc gac att act ctg aag gga cgc aca gtt atc gtg      503
 Ile Pro Glu Asn Val Asp Ile Thr Leu Lys Gly Arg Thr Val Ile Val
             115                 120                 125

 aag ggc ccc aga gga acc ctg cgg agg gac ttc aat cac atc aat gta      551
 Lys Gly Pro Arg Gly Thr Leu Arg Arg Asp Phe Asn His Ile Asn Val
         130                 135                 140

 gaa ctc agc ctt ctt gga aag aaa aaa aag agg ctc cgg gtt gac aaa      599
 Glu Leu Ser Leu Leu Gly Lys Lys Lys Lys Arg Leu Arg Val Asp Lys
     145                 150                 155

 tgg tgg ggt aac aga aag gaa ctg gct acc gtt cgg act att tgt agt      647
 Trp Trp Gly Asn Arg Lys Glu Leu Ala Thr Val Arg Thr Ile Cys Ser
 160                 165                 170                 175

 cat gta cag aac atg atc aag ggt gtt aca ctg ggc ttc cgt tac aag      695
 His Val Gln Asn Met Ile Lys Gly Val Thr Leu Gly Phe Arg Tyr Lys
                 180                 185                 190

 atg agg tct gtg tat gct cac ttc ccc atc aac gtt gtt atc cag gag      743
 Met Arg Ser Val Tyr Ala His Phe Pro Ile Asn Val Val Ile Gln Glu
             195                 200                 205

 aat ggg tct ctt gtt gaa atc cga aat ttc ttg ggt gaa aaa tac atc      791
 Asn Gly Ser Leu Val Glu Ile Arg Asn Phe Leu Gly Glu Lys Tyr Ile
         210                 215                 220

 cgc agg gtt cgg atg aga cca ggt gtt gct tgt tca gta tct caa gcc      839
 Arg Arg Val Arg Met Arg Pro Gly Val Ala Cys Ser Val Ser Gln Ala
     225                 230                 235

 cag aaa gat gaa tta atc ctt gaa gga aat gac att gag ctt gtt tca      887
 Gln Lys Asp Glu Leu Ile Leu Glu Gly Asn Asp Ile Glu Leu Val Ser
 240                 245                 250                 255

 aat tca gcg gct ttg att cag caa gcc aca aca gtt aaa aac aag gat      935
 Asn Ser Ala Ala Leu Ile Gln Gln Ala Thr Thr Val Lys Asn Lys Asp
                 260                 265                 270

 atc agg aaa ttt ttg gat ggt atc tat gtc tct gaa aaa gga act gtt      983
 Ile Arg Lys Phe Leu Asp Gly Ile Tyr Val Ser Glu Lys Gly Thr Val
             275                 280                 285

 cag cag gct gat gaa taagatctaa gagttacctg gctacagaaa gaagatgcca     1038
 Gln Gln Ala Asp Glu 
         290

 gatgacactt aagacctact tgtgatattt aaatgatgca ataaaagacc tattgatttg   1098

 gaccttcttc ttaaaaaaaa aa                                            1120




      <210> 92
      <211> 926
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (832)..(915)

      <220>
      <221> misc_feature
      <222> (1)...(926)
      <223> n = a,t,c or g

      <400> 92
 gaccttttcc cacggtgggg ggggggtacc ggctccggct cgcggccggg gtggtgtgcc     60

 cccacgcccc cctaggtctt ttttctgtcc tggtggggtc cttttttccc ccacccaggt    120

 gggggctgtn tccacaacag cggtttgagg aatgccaagg gcaccccccg gggatgcttg    180

 ccccacatgc ggcggggaaa ccctttgccc ccaaaaagaa aatctttcta aggagggatt    240

 cccctgggat atcatgccct agactggaaa gatctaggtc gatccccatg ctcccaatcg    300

 tccgacctca tagacccctt gagacgtnag taagtaagta gtagatatat cgttcattaa    360

 tgcacattag ctaacattga acaattaatc caattttaca tatatttaaa atttagcaat    420

 actgcatttt ataacataaa agctcaatca ctaaaatgat ctacaattct attataaatt    480

 cacttntaac taaaaaatat tttctatcac tgtaatacag aggcatatta ctctgaacat    540

 cgacctcata catcactcaa taagttaacc acaaagagcc tctccactta gattttcatc    600

 aagcatctta cattttaatg tccttacttt tttacagaag aggccataat ttccacctaa    660

 tgagtctata tgtgatgcag caataattga tcacatgctt tcacatgtga ataggaacaa    720

 tgaaacagca tgaagtaatt tgatacttga attatatcat aatttgcttt tcaaaaattt    780

 tatatatata catattttta aaagcatact ttgggctggg tgcagtggct c atg gct     837
                                                          Met Ala
                                                            1

 gca atc cca gca ctc tgg gag gcc aag gtg ggc aga tca ctt gag atg      885
 Ala Ile Pro Ala Leu Trp Glu Ala Lys Val Gly Arg Ser Leu Glu Met
           5                  10                  15

 aag agt ttg aga cca ccc tgg aca aaa tgg tgaaatccca c                 926
 Lys Ser Leu Arg Pro Pro Trp Thr Lys Trp 
      20                  25





      <210> 93
      <211> 2143
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (597)..(902)

      <400> 93
 ggcttccttt aatagacttt aatatagctc atttacaatc gtatgaaaat ccatcaagat     60

 caatcatgtt gcacaatccc taaaggataa aactgaggga agtcatggat aattttcaca    120

 gcttcattgt aaagtccaag atcaaaagga tggctatctt ctttaaactg gacataagat    180

 gtacacaaga tggtggcctt ggcggttact cttccaacca cttccacaat tccagagatt    240

 tcttcatcaa ggggttccat caactcgatg gttccatttt ttccttctcc atctgaaaga    300

 ataaacattt ttccggtggg atgaatcttt ctgcgatcac aggattcccg gcggtgactt    360

 gaccccggaa gtggggtgtg aagctccggt gctggtgcgg cgggggactg cggggccagc    420

 ctcaggtagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag    480

 cagctgcttc attgtttcac ttcttcagaa agcctccgga atctaaaaag ccctcagtac    540

 cagagacaga agcagatgga ttcgtccttt taggagatac aacagatgag caaaga        596                                                                 
 atg aca gca aga ggc aaa act tcg gac ata gag gcc aac caa cct ttg      644
 Met Thr Ala Arg Gly Lys Thr Ser Asp Ile Glu Ala Asn Gln Pro Leu
   1               5                  10                  15

 gag acc aac aaa gaa aat tca tcc agt gtg act gta tca gac cct gag      692
 Glu Thr Asn Lys Glu Asn Ser Ser Ser Val Thr Val Ser Asp Pro Glu
              20                  25                  30

 atg gaa aat aag gca ggc cag act ctg gag aac agc tca tta atg gcc      740
 Met Glu Asn Lys Ala Gly Gln Thr Leu Glu Asn Ser Ser Leu Met Ala
          35                  40                  45

 gag ctc ctg agc gat gtg ccg ttc acc ctg gcc ccg cat gtg ctg gca      788
 Glu Leu Leu Ser Asp Val Pro Phe Thr Leu Ala Pro His Val Leu Ala
      50                  55                  60

 gta cag ggc acc atc act gac ctt ccc gac cac tta ctc tcc tat gat      836
 Val Gln Gly Thr Ile Thr Asp Leu Pro Asp His Leu Leu Ser Tyr Asp
  65                  70                  75                  80

 ggc agc gaa aac tta tca cgg ttt tgg tat gat ttc act ctt gaa aat      884
 Gly Ser Glu Asn Leu Ser Arg Phe Trp Tyr Asp Phe Thr Leu Glu Asn
                  85                  90                  95

 tca gtg ctc tgt gat tca taacct ttatgtctgt ttgcacctta acagctttaa      938
 Ser Val Leu Cys Asp Ser 
             100

 aatatgttcg cctattttat ctaacctgtt tgatgttctt tgccgtttca ctgtttaagg    998

 tcctcagcaa ggatcataaa gcaaagaaaa tagcattatg ttcactactc tatttttaag   1058

 aaaaaggtac atttgtatac aaattgaact taagttccac ttcctttctc ccatataata   1118

 aatatacaaa ttaggctatg aaggttttag gaaaggactc gattccttca gatggtctct   1178

 caaaatataa cacctcaaat ttatcttaga agaactgtga aaaagaattg tggcattttt   1238

 cagtcactac agctccgaag tctgagcaag aagtgggtgt gaagtctcct ctctggtttg   1298

 taggaagttg aattagtgtt attcctgcat ttttttcttc cacagtgttt atgaatgaat   1358

 tcagaaaaaa agttgccagt tagcttaatt tcttcagatg cattgatgtg gaaatttaaa   1418

 acttgtccta aacagcagtg ctagtttgct gatacaagga tgctagacct gctctgcgtg   1478

 ctctttctgg agtggcccat ttcggttttc tgaaacccat ggcagccctt tccatcgtga   1538

 ataatcgttg tgttcccacc tttgttctct gcctttttgc tacttcagtg tgctctctga   1598

 ccagctttcc aaagaacttt ccctgcttct gcctcggttg ccatttgctc tccttaccac   1658

 atatgttccc agtttatgaa gagatccaca tttcctttca acccctctgc ctcctgaaga   1718

 aaaacatctc atgatgatac atattattgc tgataacacc cttatttaga aatttgttgg   1778

 ccacaataca gatggaaatg ttttactgct ggaaaaactg aaatcaactc atttccaatt   1838

 agagtatagg cagaacacct agatatgact tttagttctt gaatatccat tacttacttt   1898

 aatgaaaaca gaactgccat tggtcaataa actgtaaagg gaagaggtaa attgtgatag   1958

 agaattttct atgtcatggg aaattgaaat cacatttatt ttgattacca gcaatatgat   2018

 ttgttaactc tgtgccaagt tttaagtata ttttttcaca aagatagagt gccatagtga   2078

 aactaaacac tgtgcataaa ggtacatgaa ttattccagt tttaaagtat tatgcatgtt   2138

 tgttt                                                               2143




      <210> 94
      <211> 4382
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (362)..(3331)

      <400> 94
 cccaggccct cctcactctg gatgagccgg acaagtccca ggggcaggac ctccaagaac     60

 agctggctga ggggtgtaga ctggcacagc accttgtcca aaagctcagc ccagggaggt    120

 gcagaaggct gaagagagca aagtccctga ggactcactg gaggaatgtg ccatcacttg    180

 ttcaaatagc cacggccctt gtgactccaa ccagcctcac aagaacatca aaatcacatt    240

 tgaggaagac gaagtcaact caactctggt tgtagacaga gaatcctctc atgatgaatg    300

 tcaggatgct ctaaacattc tcccagtccc tggccccacc tcttctgcca caaacgtcag    360

 c    atg gtg gta tca gcc ggc cct ttg tcc ggc gag aag gca gcg ata     406
      Met Val Val Ser Ala Gly Pro Leu Ser Gly Glu Lys Ala Ala Ile
        1               5                  10                  15

 aac att cta gaa atc aat gag aaa ttg cgc ccc cag ctg gca gag aag      454
 Asn Ile Leu Glu Ile Asn Glu Lys Leu Arg Pro Gln Leu Ala Glu Lys
                  20                  25                  30

 aaa cag cag ttc aga aac ctc aaa gag aga tgt ttt cta act caa ctg      502
 Lys Gln Gln Phe Arg Asn Leu Lys Glu Arg Cys Phe Leu Thr Gln Leu
              35                  40                  45

 gcc ggc ttc ctg gcc aac cag cag aac aaa tac aaa tat gaa gag tgc      550
 Ala Gly Phe Leu Ala Asn Gln Gln Asn Lys Tyr Lys Tyr Glu Glu Cys
          50                  55                  60

 aaa gac ctc ata aaa ttt atg ctg agg aat gag cga cag ttc aag gag      598
 Lys Asp Leu Ile Lys Phe Met Leu Arg Asn Glu Arg Gln Phe Lys Glu
      65                  70                  75

 gag aag ctt gca gag cag ctc aag caa gct gag gag ctc agg caa tat      646
 Glu Lys Leu Ala Glu Gln Leu Lys Gln Ala Glu Glu Leu Arg Gln Tyr
  80                  85                  90                  95

 aaa gtc ctg gtt cac gct cag gaa cga gag ctg acc cag tta agg gag      694
 Lys Val Leu Val His Ala Gln Glu Arg Glu Leu Thr Gln Leu Arg Glu
                 100                 105                 110

 aag ttg cgg gaa ggg aga gat gcc tcc cgc tca ttg aat gag cat ctc      742
 Lys Leu Arg Glu Gly Arg Asp Ala Ser Arg Ser Leu Asn Glu His Leu
             115                 120                 125

 cag gcc ctc ctc act ccg gat gag ccg gac aag tcc cag ggg cag gac      790
 Gln Ala Leu Leu Thr Pro Asp Glu Pro Asp Lys Ser Gln Gly Gln Asp
         130                 135                 140

 ctc caa gaa cag ctg gct gag ggg tgt aga ctg gca cag cac ctt gtc      838
 Leu Gln Glu Gln Leu Ala Glu Gly Cys Arg Leu Ala Gln His Leu Val
     145                 150                 155

 caa aag ctc agc cca gaa aat gac aac gat gac gat gaa gat gtt caa      886
 Gln Lys Leu Ser Pro Glu Asn Asp Asn Asp Asp Asp Glu Asp Val Gln
 160                 165                 170                 175

 gtt gag gtg gct gag aaa gtg cag aaa tcg tct gcc ccc agg gag atg      934
 Val Glu Val Ala Glu Lys Val Gln Lys Ser Ser Ala Pro Arg Glu Met
                 180                 185                 190

 cag aag gct gaa gaa aag gaa gtc cct gag gac tca ctg gag gaa tgt      982
 Gln Lys Ala Glu Glu Lys Glu Val Pro Glu Asp Ser Leu Glu Glu Cys
             195                 200                 205

 gcc atc act tgt tca aat agc cat ggc cct tat gac tcc aac cag cca     1030
 Ala Ile Thr Cys Ser Asn Ser His Gly Pro Tyr Asp Ser Asn Gln Pro
         210                 215                 220

 cat aag aaa acc aaa atc aca ttt gag gaa gac aaa gtc gac tca act     1078
 His Lys Lys Thr Lys Ile Thr Phe Glu Glu Asp Lys Val Asp Ser Thr
     225                 230                 235

 ctc att ggc tca tcc tct cat gtt gaa tgg gag gat gct gta cac att     1126
 Leu Ile Gly Ser Ser Ser His Val Glu Trp Glu Asp Ala Val His Ile
 240                 245                 250                 255

 att cca gaa aat gaa agt gat gat gag gaa gag gaa gaa aaa ggg cca     1174
 Ile Pro Glu Asn Glu Ser Asp Asp Glu Glu Glu Glu Glu Lys Gly Pro
                 260                 265                 270

 gtg tct ccc agg aat ctg cag gag tct gaa gag gag gaa gtc ccc cag     1222
 Val Ser Pro Arg Asn Leu Gln Glu Ser Glu Glu Glu Glu Val Pro Gln
             275                 280                 285

 gag tcc tgg gat gaa ggt tat tcg act ctc tca att cct cct gaa atg     1270
 Glu Ser Trp Asp Glu Gly Tyr Ser Thr Leu Ser Ile Pro Pro Glu Met
         290                 295                 300

 ttg gcc tcg tac cag tct tac agc agc aca ttt cac tca tta gag gaa     1318
 Leu Ala Ser Tyr Gln Ser Tyr Ser Ser Thr Phe His Ser Leu Glu Glu
     305                 310                 315

 cag caa gtc tgc atg gct gtt gac ata ggc aga cat cgg tgg gat caa     1366
 Gln Gln Val Cys Met Ala Val Asp Ile Gly Arg His Arg Trp Asp Gln
 320                 325                 330                 335

 gtg aaa aag gag gac cac gag gca aca ggt ccc agg ctc agc aga gag     1414
 Val Lys Lys Glu Asp His Glu Ala Thr Gly Pro Arg Leu Ser Arg Glu
                 340                 345                 350

 ctg ctg gat gag aaa ggg cct gaa gtc ttg cag gac tca ctg gat aga     1462
 Leu Leu Asp Glu Lys Gly Pro Glu Val Leu Gln Asp Ser Leu Asp Arg
             355                 360                 365

 tgt tat tca act cct tca ggt tgt ctt gaa ctg act gac tca tgc cag     1510
 Cys Tyr Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr Asp Ser Cys Gln
         370                 375                 380

 ccc tac aga agt gcc ttt tac gta ttg gag caa cag cgt gtt ggc ttg     1558
 Pro Tyr Arg Ser Ala Phe Tyr Val Leu Glu Gln Gln Arg Val Gly Leu
     385                 390                 395

 gct gtt aac atg gat gaa att gaa aag tac caa gaa gtg gaa gaa gac     1606
 Ala Val Asn Met Asp Glu Ile Glu Lys Tyr Gln Glu Val Glu Glu Asp
 400                 405                 410                 415

 caa gac cca tca tgc ccc agg ctc agc agg gag ctg ctg gat gag aaa     1654
 Gln Asp Pro Ser Cys Pro Arg Leu Ser Arg Glu Leu Leu Asp Glu Lys
                 420                 425                 430

 gag cct gaa gtc ttg cag gac tca ctg ggt aga tgt tat tcg act cct     1702
 Glu Pro Glu Val Leu Gln Asp Ser Leu Gly Arg Cys Tyr Ser Thr Pro
             435                 440                 445

 tca ggt tat ctt gaa ctg cct gac tta ggc cag ccc tac agc agt gct     1750
 Ser Gly Tyr Leu Glu Leu Pro Asp Leu Gly Gln Pro Tyr Ser Ser Ala
         450                 455                 460

 gtt tac tca ttg gag gaa cag tac ctt ggc ttg gct ctt gac gtg gac     1798
 Val Tyr Ser Leu Glu Glu Gln Tyr Leu Gly Leu Ala Leu Asp Val Asp
     465                 470                 475

 aga att aaa aag gac caa gaa gag gaa gaa gac caa ggc cca cca tgc     1846
 Arg Ile Lys Lys Asp Gln Glu Glu Glu Glu Asp Gln Gly Pro Pro Cys
 480                 485                 490                 495

 ccc agg ctc agc agg gag ctg ctg gag gta gta gag cct gaa gtc ttg     1894
 Pro Arg Leu Ser Arg Glu Leu Leu Glu Val Val Glu Pro Glu Val Leu
                 500                 505                 510

 cag gac tca ctg gat aga tgt tat tca act cct tcc agt tgt ctt gaa     1942
 Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Ser Cys Leu Glu
             515                 520                 525

 cag cct gac tcc tgc cag ccc tat gga agt tcc ttt tat gca ttg gag     1990
 Gln Pro Asp Ser Cys Gln Pro Tyr Gly Ser Ser Phe Tyr Ala Leu Glu
         530                 535                 540

 gaa aag cat gtt ggc ttt tct ctt gac gtg gga gaa att gaa aag aag     2038
 Glu Lys His Val Gly Phe Ser Leu Asp Val Gly Glu Ile Glu Lys Lys
     545                 550                 555

 ggg aag ggg aag aaa aga agg gga aga aga tca aag aag gaa aga aga     2086
 Gly Lys Gly Lys Lys Arg Arg Gly Arg Arg Ser Lys Lys Glu Arg Arg
 560                 565                 570                 575

 agg gga aga aaa gaa ggg gaa gaa gat caa aac cca cca tgc ccc agg     2134
 Arg Gly Arg Lys Glu Gly Glu Glu Asp Gln Asn Pro Pro Cys Pro Arg
                 580                 585                 590

 ctc agc agg gag ctg ctg gat gag aaa ggg cct gaa gtc ttg cag gac     2182
 Leu Ser Arg Glu Leu Leu Asp Glu Lys Gly Pro Glu Val Leu Gln Asp
             595                 600                 605

 tca ctg gat aga tgt tat tca act cct tca ggt tgt ctt gaa ctg act     2230
 Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr
         610                 615                 620

 gac tca tgc cag ccc tac aga agt gcc ttt tac ata ttg gag caa cag     2278
 Asp Ser Cys Gln Pro Tyr Arg Ser Ala Phe Tyr Ile Leu Glu Gln Gln
     625                 630                 635

 cgt gtt ggc ttg gct gtt gac atg gat gaa att gaa aag tac caa gaa     2326
 Arg Val Gly Leu Ala Val Asp Met Asp Glu Ile Glu Lys Tyr Gln Glu
 640                 645                 650                 655

 gtg gaa gaa gac caa gac cca tca tgc ccc agg ctc agc ggg gag ctg     2374
 Val Glu Glu Asp Gln Asp Pro Ser Cys Pro Arg Leu Ser Gly Glu Leu
                 660                 665                 670

 ttg gat gag aaa gag cct gaa gtc ttg cag gag tca ctg gat aga tgc     2422
 Leu Asp Glu Lys Glu Pro Glu Val Leu Gln Glu Ser Leu Asp Arg Cys
             675                 680                 685

 tat tca act cct tca ggt tgt ctt gaa ctg act gac tca tgc cag ccc     2470
 Tyr Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr Asp Ser Cys Gln Pro
         690                 695                 700

 tac aga agt gcc ttt tac ata ttg gag caa cag cgt gtt ggc ttg gct     2518
 Tyr Arg Ser Ala Phe Tyr Ile Leu Glu Gln Gln Arg Val Gly Leu Ala
     705                 710                 715

 gtt gac atg gat gaa att gaa aag tac caa gaa gtg gaa gaa gac caa     2566
 Val Asp Met Asp Glu Ile Glu Lys Tyr Gln Glu Val Glu Glu Asp Gln
 720                 725                 730                 735

 gac cca tca tgc ccc agg ctc agc agg gag ctg ctg gct gag aaa gag     2614
 Asp Pro Ser Cys Pro Arg Leu Ser Arg Glu Leu Leu Ala Glu Lys Glu
                 740                 745                 750

 cct gaa gtc ttg cag gac tca ctg gat aga tgt tat tcg act cct tca     2662
 Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser
             755                 760                 765

 ggt tat ctt gaa ctg cct gac tta ggc cag ccc tac agc agt gct gtt     2710
 Gly Tyr Leu Glu Leu Pro Asp Leu Gly Gln Pro Tyr Ser Ser Ala Val
         770                 775                 780

 tac tca ttg gag gaa cag tac ctt ggc ttg gct ctt gac gtg gac aga     2758
 Tyr Ser Leu Glu Glu Gln Tyr Leu Gly Leu Ala Leu Asp Val Asp Arg
     785                 790                 795

 att aaa aag gac caa gaa gag gaa gaa gac caa ggc cca cca tgc ccc     2806
 Ile Lys Lys Asp Gln Glu Glu Glu Glu Asp Gln Gly Pro Pro Cys Pro
 800                 805                 810                 815

 agg ctc agc agg gag ctg ctg gag gta gta gag cct gaa gtc ttg cag     2854
 Arg Leu Ser Arg Glu Leu Leu Glu Val Val Glu Pro Glu Val Leu Gln
                 820                 825                 830

 gac tca ctg gat aga tgt tat tca act cct tcc agt tgt ctt gaa cag     2902
 Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Ser Cys Leu Glu Gln
             835                 840                 845

 cct gac tcc tgc cag ccc tat gga agt tcc ttt tat gca ttg gag gaa     2950
 Pro Asp Ser Cys Gln Pro Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu
         850                 855                 860

 aaa cat gtt ggc ttt tct ctt gac gtg gga gaa att gaa aag aag ggg     2998
 Lys His Val Gly Phe Ser Leu Asp Val Gly Glu Ile Glu Lys Lys Gly
     865                 870                 875

 aag ggg aag aaa aga agg gga aga aga tca aag aag gaa aga aga agg     3046
 Lys Gly Lys Lys Arg Arg Gly Arg Arg Ser Lys Lys Glu Arg Arg Arg
 880                 885                 890                 895

 gga aga aaa gaa ggg gaa gaa gat caa aac cca cca tgc ccc agg ctc     3094
 Gly Arg Lys Glu Gly Glu Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu
                 900                 905                 910

 aac agc atg ctg atg gaa gtg gaa gag cct gaa gtc ttg cag gac tca     3142
 Asn Ser Met Leu Met Glu Val Glu Glu Pro Glu Val Leu Gln Asp Ser
             915                 920                 925

 ctg gat ata tgt tat tcg act ccg tca atg tac ttt gaa cta cct gac     3190
 Leu Asp Ile Cys Tyr Ser Thr Pro Ser Met Tyr Phe Glu Leu Pro Asp
         930                 935                 940

 tca ttc cag cac tac aga agt gtg ttt tac tca ttt gag gaa gag cat     3238
 Ser Phe Gln His Tyr Arg Ser Val Phe Tyr Ser Phe Glu Glu Glu His
     945                 950                 955

 atc agc ttc gcc ctt tac gtg gac aat agg ttt ttt act ttg acg gtg     3286
 Ile Ser Phe Ala Leu Tyr Val Asp Asn Arg Phe Phe Thr Leu Thr Val
 960                 965                 970                 975

 aca agt ctc cac ctg gtg ttc cag atg gga gtc ata ttc cca caa taa     3334
 Thr Ser Leu His Leu Val Phe Gln Met Gly Val Ile Phe Pro Gln 
                 980                 985                 990

 acagccctta ctaagccgag agatgtcatt cctgcaggca ggacctatag gcacgtgaag   3394

 atttgaatga aagtacagtt ccatttggaa gcccagacat aggatgggtc agtgggcatg   3454

 gctctattcc tattctcaaa ccatgccagt ggcaacctgt gctcagtctg aagacaatgg   3514

 acccacgtta ggtgtgacac gttcacataa ctgtgcagca catgccggga gtgatcagtc   3574

 agacatttta atttgaacca cgtatctctg ggtagctaca aaattcctca gggatttcat   3634

 tttgcaggca tgtctctgag cttctatacc tgctcaaggt cattgtcatc tttgtgttta   3694

 gctcatccaa aggtgttacc ctggtttcaa tgaacctaac ctcattcttt gtgtcttcag   3754

 tgttggcttg ttttagctga tccatctgta acacaggagg gatccttggc tgaggattgt   3814

 atttcagaac caccaactgc tcttgacaat tgttaacccg ctaggctcct ttggttagag   3874

 aagccacagt ccttcagcct ccaattggtg tcagtactta ggaagaccac agctagatgg   3934

 acaaacagca ttgggaggcc ttagccctgc tcctctcaat tccatcctgt agagaacagg   3994

 agtcaggagc cgctggcagg agacagcatg tcacccagga ctctgccggt gcagaatatg   4054

 agcaatgcca tgttcttgca gaaaacgctt aacctgagtt tcataggagg taatcaccag   4114

 acaactgcag aatgtagaac actgagcagg acaactgacc tgtctccttc acatagtcca   4174

 tatcaccaca aatcacacaa caaaaaggag aagagatatt ttcggttgaa aaaaagtaaa   4234

 aagataatta gctgcatttc tttagttatt ttgaacccca aatatttcct catctttttg   4294

 gtgttgtcat tgatggtggc gacatggact tgtttataga ggacaggtca gctctctggc   4354

 tcaatgatct acatttctga agttgtcc                                      4382




      <210> 95
      <211> 824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(445)

      <220>
      <221> misc_feature
      <222> (1)...(824)
      <223> n = a,t,c or g

      <400> 95
 tggcgcctcg gaggcgttca gctgcttcaa g   atg aag ctg aac atc tcc ttc      52
                                      Met Lys Leu Asn Ile Ser Phe
                                        1               5

 cca gcc act ggc tgc cag aaa ctc att gaa gtg gac gat gaa cgc aaa      100
 Pro Ala Thr Gly Cys Gln Lys Leu Ile Glu Val Asp Asp Glu Arg Lys
          10                  15                  20

 ctt cgt act ttc tat gag aag cgt atg gcc aca gaa gtt gct gct gac      148
 Leu Arg Thr Phe Tyr Glu Lys Arg Met Ala Thr Glu Val Ala Ala Asp
      25                  30                  35

 gct ctg ggt gaa gaa tgg aag ggt tat gtg gtc cga atc agt ggt ggg      196
 Ala Leu Gly Glu Glu Trp Lys Gly Tyr Val Val Arg Ile Ser Gly Gly
  40                  45                  50                  55

 aac gac aaa caa ggt ttc ccc atg aag cag ggt gtc ttg acc cat ggc      244
 Asn Asp Lys Gln Gly Phe Pro Met Lys Gln Gly Val Leu Thr His Gly
                  60                  65                  70

 cgt gtc cgc ctg cta ctg agt aag ggg cat tcc tgt tac aga cca agg      292
 Arg Val Arg Leu Leu Leu Ser Lys Gly His Ser Cys Tyr Arg Pro Arg
              75                  80                  85

 aga act gga gaa aga aag aga aaa tca gtt cgt ggt tgc att gtg gat      340
 Arg Thr Gly Glu Arg Lys Arg Lys Ser Val Arg Gly Cys Ile Val Asp
          90                  95                 100

 gca aat ctg agc gtt ctc aac ttg gtt att gta aaa aaa gga gag aag      388
 Ala Asn Leu Ser Val Leu Asn Leu Val Ile Val Lys Lys Gly Glu Lys
     105                 110                 115

 gat att cct gga ctg act gat act aca gtg cct cgc cgc ctg ggg ccc      436
 Asp Ile Pro Gly Leu Thr Asp Thr Thr Val Pro Arg Arg Leu Gly Pro
 120                 125                 130                 135

 caa aag agc tagcaga atccgcaaac ttttcaatct ctctaaagaa gatgatgtcc      492
 Gln Lys Ser 


 gccagtatgt tgtaagaaag cccttaaata aagaaggtaa gaaacctagg accaaagcac    552

 ccaagattca gcgtcttgtt actccacgtg tcctgcagca caaacggcgg cgtattgctc    612

 tgaagaagca gcgtaccaag aaaaataaag aagaggctgc agaatatgct taacctttgg    672

 gccnagagaa tgaaggaagg ctaaggagaa gcgccaggaa ccaatttgcg aagagacgca    732

 gactttctcc tctgcgagct ttttacttcc aagtctgaat tcaagtacag aattaagatt    792

 ttttggagta acaaataaat atagttccga ct                                  824




      <210> 96
      <211> 762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (102)..(695)

      <400> 96
 ctggcggtcc cgggtgctgc tggttagtgt gctctgaggg agggtccgag ccagccgctg     60

 ttttgccgga ggagcccctc aggccgtagt aagcattaat a    atg tct ttc atc     113
                                                  Met Ser Phe Ile
                                                    1

 ttt gag tgg atc tac aat ggc ttc agc agt gtg ctc cag ttc cta gga      161
 Phe Glu Trp Ile Tyr Asn Gly Phe Ser Ser Val Leu Gln Phe Leu Gly
   5                  10                  15                  20

 ctg tac aag aaa tct gga aaa ctt gta ttc tta ggt ttg gat aat gca      209
 Leu Tyr Lys Lys Ser Gly Lys Leu Val Phe Leu Gly Leu Asp Asn Ala
                  25                  30                  35

 ggc aaa acc act ctt ctt cac atg ctc aaa gat gac aga ttg ggc caa      257
 Gly Lys Thr Thr Leu Leu His Met Leu Lys Asp Asp Arg Leu Gly Gln
              40                  45                  50

 cat gtt cca aca cta cat ccg aca tca gaa gag cta aca att gct gga      305
 His Val Pro Thr Leu His Pro Thr Ser Glu Glu Leu Thr Ile Ala Gly
          55                  60                  65

 atg acc ttt aca act ttt gat ctt ggt ggg cac gag caa gca cgt cgc      353
 Met Thr Phe Thr Thr Phe Asp Leu Gly Gly His Glu Gln Ala Arg Arg
      70                  75                  80

 gtt tgg aaa aat tat ctc cca gca att aat ggg att gtc ttt ctg gtg      401
 Val Trp Lys Asn Tyr Leu Pro Ala Ile Asn Gly Ile Val Phe Leu Val
  85                  90                  95                 100

 gac tgt gca gat cat tct cgc ctc gtg gaa tcc aaa gtt gag ctt aat      449
 Asp Cys Ala Asp His Ser Arg Leu Val Glu Ser Lys Val Glu Leu Asn
                 105                 110                 115

 gct tta atg act gat gaa aca ata tcc aat gtg cca atc ctt atc ttg      497
 Ala Leu Met Thr Asp Glu Thr Ile Ser Asn Val Pro Ile Leu Ile Leu
             120                 125                 130

 ggt aac aaa att gac aga aca gat gca atc agt gaa gaa aaa ctc cgt      545
 Gly Asn Lys Ile Asp Arg Thr Asp Ala Ile Ser Glu Glu Lys Leu Arg
         135                 140                 145

 gag ata ttt ggg ctt tat gga cag acc aca gga aag ggg aat gtg acc      593
 Glu Ile Phe Gly Leu Tyr Gly Gln Thr Thr Gly Lys Gly Asn Val Thr
     150                 155                 160

 ctg aag gag ctg aat gct cgc ccc atg gaa gtg ttc atg tgc agt gtg      641
 Leu Lys Glu Leu Asn Ala Arg Pro Met Glu Val Phe Met Cys Ser Val
 165                 170                 175                 180

 ctc aag agg caa ggt tac ggc gag ggt ttc cgc tgg ctc tcc cag tat      689
 Leu Lys Arg Gln Gly Tyr Gly Glu Gly Phe Arg Trp Leu Ser Gln Tyr
                 185                 190                 195

 att gac tgatgtttgg acggtgaaaa taaaagagtt ttacttctct ggactgatcc       745
 Ile Asp 


 taaaaaaaaa aaaaaaa                                                   762




      <210> 97
      <211> 4231
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(3170)

      <400> 97
 caggacaggg aagagcgggc gct    atg ggg agc cgg acg cca gag tcc cct      50
                              Met Gly Ser Arg Thr Pro Glu Ser Pro
                                1               5

 ctc cac gcc gtg cag ctg cgc tgg ggc ccc cgg cgc cga ccc ccg ctc       98
 Leu His Ala Val Gln Leu Arg Trp Gly Pro Arg Arg Arg Pro Pro Leu
  10                  15                  20                  25

 gtg ccg ctg ctg ttg ctg ctc gtg ccg ccg cca ccc agg gtc ggg ggc      146
 Val Pro Leu Leu Leu Leu Leu Val Pro Pro Pro Pro Arg Val Gly Gly
                  30                  35                  40

 ttc aac tta gac gcg gag gcc cca gca gta ctc tcg ggg ccc ccg ggc      194
 Phe Asn Leu Asp Ala Glu Ala Pro Ala Val Leu Ser Gly Pro Pro Gly
              45                  50                  55

 tcc ttc ttc gga ttc tca gtg gag ttt tac cgg ccg gga aca gac ggg      242
 Ser Phe Phe Gly Phe Ser Val Glu Phe Tyr Arg Pro Gly Thr Asp Gly
          60                  65                  70

 gtc agt gtg ctg gtg gga gca ccc aag gct aat acc agc cag cca gga      290
 Val Ser Val Leu Val Gly Ala Pro Lys Ala Asn Thr Ser Gln Pro Gly
      75                  80                  85

 gtg ctg cag ggt ggt gct gtc tac ctc tgt cct tgg ggt gcc agc ccc      338
 Val Leu Gln Gly Gly Ala Val Tyr Leu Cys Pro Trp Gly Ala Ser Pro
  90                  95                 100                 105

 aca cag tgc acc ccc att gaa ttt gac agc aaa ggc tct cgg ctc ctg      386
 Thr Gln Cys Thr Pro Ile Glu Phe Asp Ser Lys Gly Ser Arg Leu Leu
                 110                 115                 120

 gag tcc tca ctg tcc agc tca gag gga gag gag cct gtg gag tac aag      434
 Glu Ser Ser Leu Ser Ser Ser Glu Gly Glu Glu Pro Val Glu Tyr Lys
             125                 130                 135

 tcc ttg cag tgg ttc ggg gca aca gtt cga gcc cat ggc tcc tcc atc      482
 Ser Leu Gln Trp Phe Gly Ala Thr Val Arg Ala His Gly Ser Ser Ile
         140                 145                 150

 ttg gca tgc gct cca ctg tac agc tgg cgc aca gag aag gag cca ctg      530
 Leu Ala Cys Ala Pro Leu Tyr Ser Trp Arg Thr Glu Lys Glu Pro Leu
     155                 160                 165

 agc gac ccc gtg ggc acc tgc tac ctc tcc aca gat aac ttc acc cga      578
 Ser Asp Pro Val Gly Thr Cys Tyr Leu Ser Thr Asp Asn Phe Thr Arg
 170                 175                 180                 185

 att ctg gag tat gca ccc tgc cgc tca gat ttc agc tgg gca gca gga      626
 Ile Leu Glu Tyr Ala Pro Cys Arg Ser Asp Phe Ser Trp Ala Ala Gly
                 190                 195                 200

 cag ggt tac tgc caa gga ggc ttc agt gcc gag ttc acc aag act ggc      674
 Gln Gly Tyr Cys Gln Gly Gly Phe Ser Ala Glu Phe Thr Lys Thr Gly
             205                 210                 215

 cgt gtg gtt tta ggt gga cca gga agc tat ttc tgg caa ggc cag atc      722
 Arg Val Val Leu Gly Gly Pro Gly Ser Tyr Phe Trp Gln Gly Gln Ile
         220                 225                 230

 ctg tct gcc act cag gag cag att gca gaa tct tat tac ccc gag tac      770
 Leu Ser Ala Thr Gln Glu Gln Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr
     235                 240                 245

 ctg atc aac ctg gtt cag ggg cag ctg cag act cgc cag gcc agt tcc      818
 Leu Ile Asn Leu Val Gln Gly Gln Leu Gln Thr Arg Gln Ala Ser Ser
 250                 255                 260                 265

 atc tat gat gac agc tac cta gga tac tct gtg gct gtt ggt gaa ttc      866
 Ile Tyr Asp Asp Ser Tyr Leu Gly Tyr Ser Val Ala Val Gly Glu Phe
                 270                 275                 280

 agt ggt gat gac aca gaa gac ttt gtt gct ggt gtg ccc aaa ggg aac      914
 Ser Gly Asp Asp Thr Glu Asp Phe Val Ala Gly Val Pro Lys Gly Asn
             285                 290                 295

 ctc act tac ggc tat gtc acc atc ctt aat ggc tca gac att cga tcc      962
 Leu Thr Tyr Gly Tyr Val Thr Ile Leu Asn Gly Ser Asp Ile Arg Ser
         300                 305                 310

 ctc tac aac ttc tca ggg gaa cag atg gcc tcc tac ttt ggc tat gca     1010
 Leu Tyr Asn Phe Ser Gly Glu Gln Met Ala Ser Tyr Phe Gly Tyr Ala
     315                 320                 325

 gtg gcc gcc aca gac gtc aat ggg gac ggg ctg gat gac ttg ctg gtg     1058
 Val Ala Ala Thr Asp Val Asn Gly Asp Gly Leu Asp Asp Leu Leu Val
 330                 335                 340                 345

 ggg gca ccc ctg ctc atg gat cgg acc cct gac ggg cgg cct cag gag     1106
 Gly Ala Pro Leu Leu Met Asp Arg Thr Pro Asp Gly Arg Pro Gln Glu
                 350                 355                 360

 gtg ggc agg gtc tac gtc tac ctg cag cac cca gcc ggc ata gag ccc     1154
 Val Gly Arg Val Tyr Val Tyr Leu Gln His Pro Ala Gly Ile Glu Pro
             365                 370                 375

 acg ccc acc ctt acc ctc act ggc cat gat gag ttt ggc cga ttt ggc     1202
 Thr Pro Thr Leu Thr Leu Thr Gly His Asp Glu Phe Gly Arg Phe Gly
         380                 385                 390

 agc tcc ttg acc ccc ctg ggg gac ctg gac cag gat ggc tac aat gat     1250
 Ser Ser Leu Thr Pro Leu Gly Asp Leu Asp Gln Asp Gly Tyr Asn Asp
     395                 400                 405

 gtg gcc atc ggg gct ccc ttt ggt ggg gag acc cag cag gga gta gtg     1298
 Val Ala Ile Gly Ala Pro Phe Gly Gly Glu Thr Gln Gln Gly Val Val
 410                 415                 420                 425

 ttt gta ttt cct ggg ggc cca gga ggg ctg ggc tct aag cct tcc cag     1346
 Phe Val Phe Pro Gly Gly Pro Gly Gly Leu Gly Ser Lys Pro Ser Gln
                 430                 435                 440

 gtt ctg cag ccc ctg tgg gca gcc agc cac acc cca gac ttc ttt ggc     1394
 Val Leu Gln Pro Leu Trp Ala Ala Ser His Thr Pro Asp Phe Phe Gly
             445                 450                 455

 tct gcc ctt cga gga ggc cga gac ctg gat ggc aat gga tat cct gat     1442
 Ser Ala Leu Arg Gly Gly Arg Asp Leu Asp Gly Asn Gly Tyr Pro Asp
         460                 465                 470

 ctg att gtg ggg tcc ttt ggt gtg gac aag gct gtg gta tac agg ggc     1490
 Leu Ile Val Gly Ser Phe Gly Val Asp Lys Ala Val Val Tyr Arg Gly
     475                 480                 485

 cgc ccc atc gtg tcc gct agt gcc tcc ctc acc atc ttc ccc gcc atg     1538
 Arg Pro Ile Val Ser Ala Ser Ala Ser Leu Thr Ile Phe Pro Ala Met
 490                 495                 500                 505

 ttc aac cca gag gag cgg agc tgc agc tta gag ggg aac cct gtg gcc     1586
 Phe Asn Pro Glu Glu Arg Ser Cys Ser Leu Glu Gly Asn Pro Val Ala
                 510                 515                 520

 tgc atc aac ctt agc ttc tgc ctc aat gct tct gga aaa cac gtt gct     1634
 Cys Ile Asn Leu Ser Phe Cys Leu Asn Ala Ser Gly Lys His Val Ala
             525                 530                 535

 gac tcc att ggt ttc aca gtg gaa ctt cag ctg gac tgg cag aag cag     1682
 Asp Ser Ile Gly Phe Thr Val Glu Leu Gln Leu Asp Trp Gln Lys Gln
         540                 545                 550

 aag gga ggg gta cgg cgg gca ctg ttc ctg gcc tcc agg cag gca acc     1730
 Lys Gly Gly Val Arg Arg Ala Leu Phe Leu Ala Ser Arg Gln Ala Thr
     555                 560                 565

 ctg acc cag acc ctg ctc atc cag aat ggg gct cga gag gat tgc aga     1778
 Leu Thr Gln Thr Leu Leu Ile Gln Asn Gly Ala Arg Glu Asp Cys Arg
 570                 575                 580                 585

 gag atg aag atc tac ctc agg aac gag tca gaa ttt cga gac aaa ctc     1826
 Glu Met Lys Ile Tyr Leu Arg Asn Glu Ser Glu Phe Arg Asp Lys Leu
                 590                 595                 600

 tcg ccg att cac atc gct ctc aac ttc tcc ttg gac ccc caa gcc cca     1874
 Ser Pro Ile His Ile Ala Leu Asn Phe Ser Leu Asp Pro Gln Ala Pro
             605                 610                 615

 gtg gac agc cac ggc ctc agg cca gcc cta cat tat cag agc aag agc     1922
 Val Asp Ser His Gly Leu Arg Pro Ala Leu His Tyr Gln Ser Lys Ser
         620                 625                 630

 cgg ata gag gac aag gct cag atc ttg ctg gac tgt gga gaa gac aac     1970
 Arg Ile Glu Asp Lys Ala Gln Ile Leu Leu Asp Cys Gly Glu Asp Asn
     635                 640                 645

 atc tgt gtg cct gac ctg cag ctg gaa gtg ttt ggg gag cag aac cat     2018
 Ile Cys Val Pro Asp Leu Gln Leu Glu Val Phe Gly Glu Gln Asn His
 650                 655                 660                 665

 gtg tac ctg ggt gac aag aat gcc ctg aac ctc act ttc cat gcc cag     2066
 Val Tyr Leu Gly Asp Lys Asn Ala Leu Asn Leu Thr Phe His Ala Gln
                 670                 675                 680

 aat gtg ggt gag ggt ggc gcc tat gag gct gag ctt cgg gtc acc gcc     2114
 Asn Val Gly Glu Gly Gly Ala Tyr Glu Ala Glu Leu Arg Val Thr Ala
             685                 690                 695

 cct cca gag gct gag tac tca gga ctc gtc aga cac cca ggg aac ttc     2162
 Pro Pro Glu Ala Glu Tyr Ser Gly Leu Val Arg His Pro Gly Asn Phe
         700                 705                 710

 tcc agc ctg agc tgt gac tac ttt gcc gtg aac cag agc cgc ctg ctg     2210
 Ser Ser Leu Ser Cys Asp Tyr Phe Ala Val Asn Gln Ser Arg Leu Leu
     715                 720                 725

 gtg tgt gac ctg ggc aac ccc atg aag gca gga gcc agt ctg tgg ggt     2258
 Val Cys Asp Leu Gly Asn Pro Met Lys Ala Gly Ala Ser Leu Trp Gly
 730                 735                 740                 745

 ggc ctt cgg ttt aca gtc cct cat ctc cgg gac act aag aaa acc atc     2306
 Gly Leu Arg Phe Thr Val Pro His Leu Arg Asp Thr Lys Lys Thr Ile
                 750                 755                 760

 cag ttt gac ttc cag atc ctc agc aag aat ctc aac aac tcg caa agc     2354
 Gln Phe Asp Phe Gln Ile Leu Ser Lys Asn Leu Asn Asn Ser Gln Ser
             765                 770                 775

 gac gtg gtt tcc ttt cgg ctc tcc gtg gag gct cag gcc cag gtc acc     2402
 Asp Val Val Ser Phe Arg Leu Ser Val Glu Ala Gln Ala Gln Val Thr
         780                 785                 790

 ctg aac ggt gtc tcc aag cct gag gca gtg cta ttc cca gta agc gac     2450
 Leu Asn Gly Val Ser Lys Pro Glu Ala Val Leu Phe Pro Val Ser Asp
     795                 800                 805

 tgg cat ccc cga gac cag cct cag aag gag gag gac ctc ggg cct gct     2498
 Trp His Pro Arg Asp Gln Pro Gln Lys Glu Glu Asp Leu Gly Pro Ala
 810                 815                 820                 825

 gtc cac cat gtc tat gag ctc atc aac caa ggc ccc agc tcc att agc     2546
 Val His His Val Tyr Glu Leu Ile Asn Gln Gly Pro Ser Ser Ile Ser
                 830                 835                 840

 cag ggt gtg ctg gaa ctc agc tgt ccc cag gct ctg gaa ggt cag cag     2594
 Gln Gly Val Leu Glu Leu Ser Cys Pro Gln Ala Leu Glu Gly Gln Gln
             845                 850                 855

 ctc cta tat gtg acc aga gtt acg gga ctc aac tgc acc acc aat cac     2642
 Leu Leu Tyr Val Thr Arg Val Thr Gly Leu Asn Cys Thr Thr Asn His
         860                 865                 870

 ccc att aac cca aag ggc ctg gag ttg gat ccc gag ggt tcc ctg cac     2690
 Pro Ile Asn Pro Lys Gly Leu Glu Leu Asp Pro Glu Gly Ser Leu His
     875                 880                 885

 cac cag caa aaa cgg gaa gct cca agc cgc agc tct gct tcc tcg gga     2738
 His Gln Gln Lys Arg Glu Ala Pro Ser Arg Ser Ser Ala Ser Ser Gly
 890                 895                 900                 905

 cct cag atc ctg aaa tgc ccg gag gct gag tgt ttc agg ctg cgc tgt     2786
 Pro Gln Ile Leu Lys Cys Pro Glu Ala Glu Cys Phe Arg Leu Arg Cys
                 910                 915                 920

 gag ctc ggg ccc ctg cac caa caa gag agc caa agt ctg cag ttg cat     2834
 Glu Leu Gly Pro Leu His Gln Gln Glu Ser Gln Ser Leu Gln Leu His
             925                 930                 935

 ttc cga gtc tgg gcc aag act ttc ttg cag cgg gag cac cag cca ttt     2882
 Phe Arg Val Trp Ala Lys Thr Phe Leu Gln Arg Glu His Gln Pro Phe
         940                 945                 950

 agc ctg cag tgt gag gct gtg tac aaa gcc ctg aag atg ccc tac cga     2930
 Ser Leu Gln Cys Glu Ala Val Tyr Lys Ala Leu Lys Met Pro Tyr Arg
     955                 960                 965

 atc ctg cct cgg cag ctg ccc caa aaa gag cgt cag gtg gcc aca gct     2978
 Ile Leu Pro Arg Gln Leu Pro Gln Lys Glu Arg Gln Val Ala Thr Ala
 970                 975                 980                 985

 gtg caa tgg acc aag gca gaa ggc agc tat ggc gtc cca ctg tgg atc     3026
 Val Gln Trp Thr Lys Ala Glu Gly Ser Tyr Gly Val Pro Leu Trp Ile
                 990                 995                1000

 atc atc cta gcc atc ctg ttt ggc ctc ctg ctc cta ggt cta ctc atc     3074
 Ile Ile Leu Ala Ile Leu Phe Gly Leu Leu Leu Leu Gly Leu Leu Ile
            1005                1010                1015

 tac atc ctc tac aag ctt gga ttc ttc aaa cgc tcc ctc cca tat ggc     3122
 Tyr Ile Leu Tyr Lys Leu Gly Phe Phe Lys Arg Ser Leu Pro Tyr Gly
        1020                1025                1030

 acc gcc atg gaa aaa gct cag ctc aag cct cca gcc acc tct gat gcc     3170
 Thr Ala Met Glu Lys Ala Gln Leu Lys Pro Pro Ala Thr Ser Asp Ala 
    1035                1040                1045

 tgagtcctcc caatttcaga ctcccattcc tgaagaacca gtccccccac cctcattcta   3230

 ctgaaaagga ggggtctggg tacttcttga aggtgctgac ggccagggag aagctcctct   3290

 ccccagccca gagacatact tgaagggcca gagccagggg ggtgaggagc tggggatccc   3350

 tcccccccat gcactgtgaa ggacccttgt ttacacatac cctcttcatg gatgggggaa   3410

 ctcagatcca gggacagagg ccccagcctc cctgaagcct ttgcattttg gagagtttcc   3470

 tgaaacaact ggaaagataa ctaggaaatc cattcacagt tctttgggcc agacatgcca   3530

 caaggacttc actgtccagc tccaacctgc aaagatctgt cctcagcctt gccagagatc   3590

 caaaagaagc ccccagctaa gaacctggaa cttggggagt taagacctgg cagctctgga   3650

 cagccccacc ctggtgggcc aacaaagaac actaactatg catggtgccc caggaccagc   3710

 tcaggacaga tgccacacaa ggatagatgc tggcccaggg cccagagccc agctccaagg   3770

 ggaatcagaa ctcaaatggg gccagatcca gcctggggtc tggagttgat ctggaaccca   3830

 gactcagaca ttggcaccta atccaggcag atccaggact atatttgggc ctgctccaga   3890

 cctgatcctg gaggcccagt tcaccctgat ttaggagaag ccaggaattt cccaggaccc   3950

 tgaaggggcc atgatggcaa cagatctgga acctcagcct ggccagacac aggccctccc   4010

 tgttccccag agaaagggga gcccactgtc ctgggcctgc agaatttggg ttctgcctgc   4070

 cagctgcact gatgctgccc ctcatctctc tgcccaaccc ttccctcacc ttggcaccag   4130

 acacccagga cttatttaaa ctctgttgca agtgcaataa atctgaccca gtgcccccac   4190

 tgaccagaac tagaaaaaaa aaaaaaaaaa aaaaaaaaag g                       4231




      <210> 98
      <211> 1806
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (412)..(1110)

      <400> 98
 cggtccctgg gggagtcccc agttcctttc cctccaggcc agctgcacac acttgacact     60

 gatttgcaca gtcttgcaca aatagggggt aagagcccag tggctggggt gggcaatggg    120

 ggtatcctct ggcctaggga gtcccctggc actgccaatg ggcacagtcc cgagcacaca    180

 ccccctggcc ctggaccccc aggcccctgc cccaccaagc gaaggctgct tcctgctgga    240

 gaagccccag atgtcagctc tgaggaagag gggccagccc ctcggaggcg ccggggatcc    300

 ctgggccacc ctactgctgc caacagttct gatgccaaag ccacaccctt ctggagccac    360

 ctgctgcctg ggcccaaaga gcctgttttg gacccaacag actgcggtcc c atg ggg     417
                                                          Met Gly
                                                            1

 cgg agg ctg aaa gga gcc cgt cgc ctg aag ctg agc ccc ctt cga agc      465
 Arg Arg Leu Lys Gly Ala Arg Arg Leu Lys Leu Ser Pro Leu Arg Ser
           5                  10                  15

 ctc cgg aag ggg cca ggc ctg ctg agc ccc ccc agt gcc tcc cct gtt      513
 Leu Arg Lys Gly Pro Gly Leu Leu Ser Pro Pro Ser Ala Ser Pro Val
      20                  25                  30

 cct acc cct gct gtc agc cgt acc ctg ctg ggc aac ttt gag gaa tca      561
 Pro Thr Pro Ala Val Ser Arg Thr Leu Leu Gly Asn Phe Glu Glu Ser
  35                  40                  45                  50

 ttg ctg cga gga cgt ttt gca cca tct ggc cac att gag ggc ttc aca      609
 Leu Leu Arg Gly Arg Phe Ala Pro Ser Gly His Ile Glu Gly Phe Thr
                  55                  60                  65

 gca gaa att gga gct agt ggg tca tac tgc ccc cag cac gtc acg ctg      657
 Ala Glu Ile Gly Ala Ser Gly Ser Tyr Cys Pro Gln His Val Thr Leu
              70                  75                  80

 cct gtc act gtc aca ttc ttt gat gtt tct gag caa aat gcc ccg gct      705
 Pro Val Thr Val Thr Phe Phe Asp Val Ser Glu Gln Asn Ala Pro Ala
          85                  90                  95

 ccc ttc ctg ggc atc gtg gat ctg aac ccc ttg ggg agg aag ggt tac      753
 Pro Phe Leu Gly Ile Val Asp Leu Asn Pro Leu Gly Arg Lys Gly Tyr
     100                 105                 110

 agc gtg ccc aag gtg ggc acc gtc caa gtg acc tta ttt aac ccc aac      801
 Ser Val Pro Lys Val Gly Thr Val Gln Val Thr Leu Phe Asn Pro Asn
 115                 120                 125                 130

 cag act gtg gta aag atg ttc ctt gtg acc ttt gac ttc tcg gac atg      849
 Gln Thr Val Val Lys Met Phe Leu Val Thr Phe Asp Phe Ser Asp Met
                 135                 140                 145

 cct gct gcc cac atg acc ttc ctg cgc cat cgc ctc ttt ttg gtg cct      897
 Pro Ala Ala His Met Thr Phe Leu Arg His Arg Leu Phe Leu Val Pro
             150                 155                 160

 gtg ggt gag gag gga aat gct aac ccc acc cac cgc ctc ctc tgc tac      945
 Val Gly Glu Glu Gly Asn Ala Asn Pro Thr His Arg Leu Leu Cys Tyr
         165                 170                 175

 ttg ctg cac ctc agg ttc cgg agc tcc cgc tca ggc cgc tta agc ctg      993
 Leu Leu His Leu Arg Phe Arg Ser Ser Arg Ser Gly Arg Leu Ser Leu
     180                 185                 190

 cat gga gat atc cgc ctg ctt ttt tcc cgc cgg agc ctg gag ctg gac     1041
 His Gly Asp Ile Arg Leu Leu Phe Ser Arg Arg Ser Leu Glu Leu Asp
 195                 200                 205                 210

 aca ggg ctc ccc tac gaa ctg cag gct gtg acc gag gcc cct cat aat     1089
 Thr Gly Leu Pro Tyr Glu Leu Gln Ala Val Thr Glu Ala Pro His Asn
                 215                 220                 225

 cca cgt tat tca cct ttg ccc tg attgccagca ctctgaaccc atgcgggcta     1142
 Pro Arg Tyr Ser Pro Leu Pro 
             230

 atgacctgcc catcctgctc catcttagag aacatatatg gagagacagc aagagaccct   1202

 tcaggcttga attaaagccc tcaccatgct cacgcccaaa tggattattt gggtgtttaa   1262

 agcttctgat tcttactaca ccctgcccta cttcgggtac tccatgtgcc tgtcccctcc   1322

 cttgggtttc ccaggccagc ttaggtagta gggaggaact ggagctaccc tgagattttc   1382

 tcaagttccc aggcaagtta tgccagcgtt gcctccctgt cctgggcagg ggccacttgg   1442

 tattttattt atttttaatt tataatttat tcaaattgga ttgccttggt aacctcccac   1502

 acctgataat tggcatcact cctccccgct tcccactctc agatattgct ccaacctcag   1562

 gagttgaaga gggcttatgc ggtgggggca ggaggagaac tgctttccct cagctgaggg   1622

 gaagaggggc tattccagag ggactgagtc agtagccaaa gactcagctt cccctgtcct   1682

 tccccagtcc cttcacttcc cctaccctct gacctatctc tgaaagccaa gttatgcgta   1742

 tgtgtgtgtg cacaagcttg tctttgtgtg gtatgtgtgt gtgagtgtgc atgtatgcac   1802

 acac                                                                1806




      <210> 99
      <211> 1911
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (184)..(1362)

      <400> 99
 gcacgaagcg gggccggggc tgcggggcga gttgtcggcc ctgggccggg agctggagtc     60

 ccagactcat aggtcccggc ccagcccccg aagagccgcc tcagccgggg ggagttgctc    120

 ggactcaaac gtccagtcct cgtgcgaccg cgctgggtcg gaagtgagca ggctgaggcc    180

 acc  atg gag cag tgt gcg tgc gtg gag aga gag ctg gac aag gtc ctg     228
      Met Glu Gln Cys Ala Cys Val Glu Arg Glu Leu Asp Lys Val Leu
        1               5                  10                  15

 cag aag ttc ctg acc tac ggg cag cac tgt gag cgg agc ctg gag gag      276
 Gln Lys Phe Leu Thr Tyr Gly Gln His Cys Glu Arg Ser Leu Glu Glu
                  20                  25                  30

 ctg ctg cac tac gtg ggc cag ctg cgg gct gag ctg gcc agc gca gcc      324
 Leu Leu His Tyr Val Gly Gln Leu Arg Ala Glu Leu Ala Ser Ala Ala
              35                  40                  45

 ctc cag ggg acc cct ctc tca gcc acc ctc tct ctg gtg atg tca cag      372
 Leu Gln Gly Thr Pro Leu Ser Ala Thr Leu Ser Leu Val Met Ser Gln
          50                  55                  60

 tgc tgc cgg aag atc aaa gat acg gtg cag aaa ctg gct tcg gac cat      420
 Cys Cys Arg Lys Ile Lys Asp Thr Val Gln Lys Leu Ala Ser Asp His
      65                  70                  75

 aag gac att cac agc agt gta tcc cga gtg ggc aaa gcc att gac agg      468
 Lys Asp Ile His Ser Ser Val Ser Arg Val Gly Lys Ala Ile Asp Arg
  80                  85                  90                  95

 aac ttc gac tct gag atc tgt ggt gtt gtg tca gat gcg gtg tgg gac      516
 Asn Phe Asp Ser Glu Ile Cys Gly Val Val Ser Asp Ala Val Trp Asp
                 100                 105                 110

 gcg cgg gaa cag cag cag cag atc ctg cag atg gcc atc gtg gaa cac      564
 Ala Arg Glu Gln Gln Gln Gln Ile Leu Gln Met Ala Ile Val Glu His
             115                 120                 125

 ctg tat cag cag ggc atg ctc agc gtg gcc gag gag ctg tgc cag gaa      612
 Leu Tyr Gln Gln Gly Met Leu Ser Val Ala Glu Glu Leu Cys Gln Glu
         130                 135                 140

 tca acg ctg aat gtg gac ttg gat ttc aag cag cct ttc cta gag ttg      660
 Ser Thr Leu Asn Val Asp Leu Asp Phe Lys Gln Pro Phe Leu Glu Leu
     145                 150                 155

 aat cga atc ctg gaa gcc ctg cac gaa caa gac ctg ggt cct gcg ttg      708
 Asn Arg Ile Leu Glu Ala Leu His Glu Gln Asp Leu Gly Pro Ala Leu
 160                 165                 170                 175

 gaa tgg gcc gtc tcc cac agg cag cgc ctg ctg gaa ctc aac agc tcc      756
 Glu Trp Ala Val Ser His Arg Gln Arg Leu Leu Glu Leu Asn Ser Ser
                 180                 185                 190

 ctg gag ttc aag ctg cac cga ctg cac ttc atc cgc ctc ttg gca gga      804
 Leu Glu Phe Lys Leu His Arg Leu His Phe Ile Arg Leu Leu Ala Gly
             195                 200                 205

 ggc ccc gcg aag cag ctg gag gcc ctc agc tat gct cgg cac ttc cag      852
 Gly Pro Ala Lys Gln Leu Glu Ala Leu Ser Tyr Ala Arg His Phe Gln
         210                 215                 220

 ccc ttt gct cgg ctg cac cag cgg gag atc cag gtg atg atg ggc agc      900
 Pro Phe Ala Arg Leu His Gln Arg Glu Ile Gln Val Met Met Gly Ser
     225                 230                 235

 ctg gtg tac ctg cgg ctg ggc ttg gag aag tca ccc tac tgc cac ctg      948
 Leu Val Tyr Leu Arg Leu Gly Leu Glu Lys Ser Pro Tyr Cys His Leu
 240                 245                 250                 255

 ctg gac agc agc cac tgg gca gag atc tgt gag acc ttt acc cgg gac      996
 Leu Asp Ser Ser His Trp Ala Glu Ile Cys Glu Thr Phe Thr Arg Asp
                 260                 265                 270

 gcc tgt tcc ctg ctg ggg ctt tct gtg gag tcc ccc ctt agc gtc agc     1044
 Ala Cys Ser Leu Leu Gly Leu Ser Val Glu Ser Pro Leu Ser Val Ser
             275                 280                 285

 ttt gcc tct ggc tgt gtg gcg ctg cct gtg ttg atg aac atc aag gct     1092
 Phe Ala Ser Gly Cys Val Ala Leu Pro Val Leu Met Asn Ile Lys Ala
         290                 295                 300

 gtg att gag cag cgg cag tgc act ggg gtc tgg aat cac aag gac gag     1140
 Val Ile Glu Gln Arg Gln Cys Thr Gly Val Trp Asn His Lys Asp Glu
     305                 310                 315

 tta ccg att gag att gaa cta ggc atg aag tgc tgg tac cac tcc gtg     1188
 Leu Pro Ile Glu Ile Glu Leu Gly Met Lys Cys Trp Tyr His Ser Val
 320                 325                 330                 335

 ttc gct tgc ccc atc ctc cgc cag cag acg tca gat tcc aac cct ccc     1236
 Phe Ala Cys Pro Ile Leu Arg Gln Gln Thr Ser Asp Ser Asn Pro Pro
                 340                 345                 350

 atc aag ctc atc tgt ggc cat gtt atc tcc cga gat gca ctc aat aag     1284
 Ile Lys Leu Ile Cys Gly His Val Ile Ser Arg Asp Ala Leu Asn Lys
             355                 360                 365

 ctc att aat gga gga aag ctg aag tgt ccc tac tgt ccc atg gag cag     1332
 Leu Ile Asn Gly Gly Lys Leu Lys Cys Pro Tyr Cys Pro Met Glu Gln
         370                 375                 380

 aac ccg gca gat ggg aaa cgc atc ata ttc t gattcctacc tggaaggaat     1383
 Asn Pro Ala Asp Gly Lys Arg Ile Ile Phe 
     385                 390

 tttgttgaaa ggggttttca cctgtgagcc ttggtctgtc tcggtagggt ggtcaacttc   1443

 agtggactgt ggttggtttc agagcgcctg gctgaggagt tccactgagg ggagcactgg   1503

 agcagccctt tggcagaggc tgaggaggga gatggaccag cccacgcctg gcacctggct   1563

 ccatggcata aggaaaggga gatgctggcc tctgtgctcc tgctgtcttt tcctgtttct   1623

 gtttgcgttt gacttagtag caaccgacag agtggcaagg gatttggtct tcagcagtag   1683

 acatccttcc acccctgccc tcagccaagt ctcttgctgc catgccaatg ctatgtccac   1743

 ccttgcccct cggcccaaga gtgtccagcg gtggcccacc tcttcctccc actacagcct   1803

 caacagtatg taccatctcc cactgtaaat agtcccagtt agaacggaat gccgttgttt   1863

 tataactttg aacaaatgta tttactgccc ttctcaaaaa aaaaaaaa                1911




      <210> 100
      <211> 1968
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(1665)

      <400> 100
 atagagttcg atacacaagc ggaggaattc ctggagcgtt cggcggacag tgagcatgcg     60

 taccatatct gaagttcgta aattgaaatt gaacatgcgt aattaatctt tctgaatagg    120

 aaaaaatata tacacaacaa aactctccgt ttatggaaca tgcgcatttg ttctcagtaa    180

 gtttttcgtt ttgaaagtga gcatgcgcat ggtgagtagg ttggtccgaa gtttgaaccg    240

 gacagaagcg ctggtcggcg tctggcggtt gtttttagag gtaatacacc tagtttgtgg    300

 ctcagc   atg tca att gta aca gtg caa ctt ggt cag tgt ggc aat cag     348
          Met Ser Ile Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln
            1               5                  10

 att ggt ttt gaa gtt ttt gat gct ttg ctt agt gac tca cac agt tcc      396
 Ile Gly Phe Glu Val Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser
  15                  20                  25                  30

 cag gga ctc tgc tct atg aga gag aat gag gca tat caa gca tct tgc      444
 Gln Gly Leu Cys Ser Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys
                  35                  40                  45

 aaa gaa aga ttc ttc agt gag gag gag aat gga gtt cca att gcc cgg      492
 Lys Glu Arg Phe Phe Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg
              50                  55                  60

 gct gtt ctt gtt gac atg gaa ccc aaa gtt atc aat caa acg ctg tca      540
 Ala Val Leu Val Asp Met Glu Pro Lys Val Ile Asn Gln Thr Leu Ser
          65                  70                  75

 aag gct gcc cag tct ggc caa tgg aaa tat ggt caa cat gca tgc ttc      588
 Lys Ala Ala Gln Ser Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe
      80                  85                  90

 tgt caa aaa caa ggt tct gga aac aac tgg gca tat ggt tac tct gtt      636
 Cys Gln Lys Gln Gly Ser Gly Asn Asn Trp Ala Tyr Gly Tyr Ser Val
  95                 100                 105                 110

 cat gga ccc agg cat gaa gaa tct ata atg aac ata atc cgg aag gaa      684
 His Gly Pro Arg His Glu Glu Ser Ile Met Asn Ile Ile Arg Lys Glu
                 115                 120                 125

 gtg gag aaa tgt gac tct ttc agt ggt ttt ttc atc ata atg agt atg      732
 Val Glu Lys Cys Asp Ser Phe Ser Gly Phe Phe Ile Ile Met Ser Met
             130                 135                 140

 gct ggg ggc aca gga tca gga tta gga gct ttc gtt aca cag aat tta      780
 Ala Gly Gly Thr Gly Ser Gly Leu Gly Ala Phe Val Thr Gln Asn Leu
         145                 150                 155

 gaa gat cag tac tca aac tca ttg aaa atg aat cag att att tgg cct      828
 Glu Asp Gln Tyr Ser Asn Ser Leu Lys Met Asn Gln Ile Ile Trp Pro
     160                 165                 170

 tat gga act ggt gag gtt att gtt caa aac tac aac tcc att ttg aca      876
 Tyr Gly Thr Gly Glu Val Ile Val Gln Asn Tyr Asn Ser Ile Leu Thr
 175                 180                 185                 190

 ctt tct cac ttg tac cga tct tca gac gcc ctc ctt ctt cat gag aat      924
 Leu Ser His Leu Tyr Arg Ser Ser Asp Ala Leu Leu Leu His Glu Asn
                 195                 200                 205

 gat gcc atc cat aag atc tgt gca aaa ctg atg aat atc aag cag atc      972
 Asp Ala Ile His Lys Ile Cys Ala Lys Leu Met Asn Ile Lys Gln Ile
             210                 215                 220

 tcc ttt agt gat atc aat caa gtc ctc gca cat cag ctg gga agt gtg     1020
 Ser Phe Ser Asp Ile Asn Gln Val Leu Ala His Gln Leu Gly Ser Val
         225                 230                 235

 ttc cag cct act tat tct gca gaa agc tca ttt cac tac aga cga aat     1068
 Phe Gln Pro Thr Tyr Ser Ala Glu Ser Ser Phe His Tyr Arg Arg Asn
     240                 245                 250

 cca cta gga gac tta atg gag cat tta gtt ccc cat cct gaa ttc aag     1116
 Pro Leu Gly Asp Leu Met Glu His Leu Val Pro His Pro Glu Phe Lys
 255                 260                 265                 270

 atg ctg agt gtt cgt aac att cct cac atg tct gag aat tca ttg gca     1164
 Met Leu Ser Val Arg Asn Ile Pro His Met Ser Glu Asn Ser Leu Ala
                 275                 280                 285

 tac acc aca ttt act tgg gct ggc ctc ctc aag cat ttg aga cag atg     1212
 Tyr Thr Thr Phe Thr Trp Ala Gly Leu Leu Lys His Leu Arg Gln Met
             290                 295                 300

 ctc att tct aat gca aag atg gaa gaa ggt att gat agg cat gta tgg     1260
 Leu Ile Ser Asn Ala Lys Met Glu Glu Gly Ile Asp Arg His Val Trp
         305                 310                 315

 cct cct tta tca gga ctt cct cct ctt agt aaa atg tct ctc aac aag     1308
 Pro Pro Leu Ser Gly Leu Pro Pro Leu Ser Lys Met Ser Leu Asn Lys
     320                 325                 330

 gac ctg cat ttt aac act tcc att gct aac ttg gtc att ctt cgt ggg     1356
 Asp Leu His Phe Asn Thr Ser Ile Ala Asn Leu Val Ile Leu Arg Gly
 335                 340                 345                 350

 aaa gat gtg caa agt gca gat gtg gag gga ttt aaa gat cca gct ctg     1404
 Lys Asp Val Gln Ser Ala Asp Val Glu Gly Phe Lys Asp Pro Ala Leu
                 355                 360                 365

 tat act tcc tgg ttg aag cct gtt aat gct ttc aac gtg tgg aaa acc     1452
 Tyr Thr Ser Trp Leu Lys Pro Val Asn Ala Phe Asn Val Trp Lys Thr
             370                 375                 380

 cag cgg gcc ttt agc aaa tat gag aag tct gca gtg ttg gtc agc aac     1500
 Gln Arg Ala Phe Ser Lys Tyr Glu Lys Ser Ala Val Leu Val Ser Asn
         385                 390                 395

 agc cag ttc tta gta aaa cca ctt gat atg att gtt ggg aag gca tgg     1548
 Ser Gln Phe Leu Val Lys Pro Leu Asp Met Ile Val Gly Lys Ala Trp
     400                 405                 410

 aat atg ttt gct tca aaa gcc tac att cat cag tac aca aaa ttt gga     1596
 Asn Met Phe Ala Ser Lys Ala Tyr Ile His Gln Tyr Thr Lys Phe Gly
 415                 420                 425                 430

 atc gaa gaa gag gac ttt tta gac agt ttc acg tca tta gag cag gtt     1644
 Ile Glu Glu Glu Asp Phe Leu Asp Ser Phe Thr Ser Leu Glu Gln Val
                 435                 440                 445

 gtt gcc agt tac tgt aat ctc tg atcttgaaca atgggaaaag tataccttaa     1697
 Val Ala Ser Tyr Cys Asn Leu 
             450

 ggcatttctg gactaaaata ttttcaatac tattttctct gtaaagtttt caaagttctc   1757

 catcctggct aacacggtga aacaccgtct ctaccagaaa atacaaaaaa ttagccaggc   1817

 gcggtggcgg gtgcctgtag tcccagctac tcgggaggct gaggcaggag aatgacgtga   1877

 acccaggagg cggagcttgc agtgagccga gatcgcgcca ctgcactcca gcctgggcga   1937

 cagagcgaga ctccgtctca aaaaaaaaaa a                                  1968




      <210> 101
      <211> 1662
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (307)..(1359)

      <400> 101
 atagagttcg atacacaagc ggaggaattc ctggagcgtt cggcggacag tgagcatgcg     60

 taccatatct gaagttcgta aattgaaatt gaacatgcgt aattaatctt tctgaatagg    120

 aaaaaatata tacacaacaa aactctccgt ttatggaaca tgcgcatttg ttctcagtaa    180

 gtttttcgtt ttgaaagtga gcatgcgcat ggtgagtagg ttggtccgaa gtttgaaccg    240

 gacagaagcg ctggtcggcg tctggcggtt gtttttagag gtaatacacc tagtttgtgg    300

 ctcagc   atg tca att gta aca gtg caa ctt ggt cag tgt ggc aat cag     348
          Met Ser Ile Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln
            1               5                  10

 att ggt ttt gaa gtt ttt gat gct ttg ctt agt gac tca cac agt tcc      396
 Ile Gly Phe Glu Val Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser
  15                  20                  25                  30

 cag gga ctc tgc tct atg aga gag aat gag gca tat caa gca tct tgc      444
 Gln Gly Leu Cys Ser Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys
                  35                  40                  45

 aaa gaa aga ttc ttc agt gag gag gag aat gga gtt cca att gcc cgg      492
 Lys Glu Arg Phe Phe Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg
              50                  55                  60

 gct gtt ctt gtt gac atg gaa ccc aaa gtt atc aat caa acg ctg tca      540
 Ala Val Leu Val Asp Met Glu Pro Lys Val Ile Asn Gln Thr Leu Ser
          65                  70                  75

 aag gct gcc cag tct ggc caa tgg aaa tat ggt caa cat gca tgc ttc      588
 Lys Ala Ala Gln Ser Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe
      80                  85                  90

 tgt caa aaa caa ggt tct gga aac aac tgg gca tat ggt tac tct gtt      636
 Cys Gln Lys Gln Gly Ser Gly Asn Asn Trp Ala Tyr Gly Tyr Ser Val
  95                 100                 105                 110

 cat gga ccc agg cat gaa gaa tct ata atg aac ata atc cgg aag gaa      684
 His Gly Pro Arg His Glu Glu Ser Ile Met Asn Ile Ile Arg Lys Glu
                 115                 120                 125

 gtg gag aaa tgt gac tct ttc agt ggt ttt ttc atc ata atg agt atg      732
 Val Glu Lys Cys Asp Ser Phe Ser Gly Phe Phe Ile Ile Met Ser Met
             130                 135                 140

 gct ggg ggc aca gga tca gga tta gga gct ttc gtt aca cag aat tta      780
 Ala Gly Gly Thr Gly Ser Gly Leu Gly Ala Phe Val Thr Gln Asn Leu
         145                 150                 155

 gaa gat cag tac tca aac tca ttg aaa atg aat cag att att tgg cct      828
 Glu Asp Gln Tyr Ser Asn Ser Leu Lys Met Asn Gln Ile Ile Trp Pro
     160                 165                 170

 tat gga act ggt gag gtt att gtt caa aac tac aac tcc att ttg aca      876
 Tyr Gly Thr Gly Glu Val Ile Val Gln Asn Tyr Asn Ser Ile Leu Thr
 175                 180                 185                 190

 ctt tct cac ttg tac cga tct tca gac gcc ctc ctt ctt cat gag aat      924
 Leu Ser His Leu Tyr Arg Ser Ser Asp Ala Leu Leu Leu His Glu Asn
                 195                 200                 205

 gat gcc atc cat aag atc tgt gca aaa ctg atg aat atc aag cag atc      972
 Asp Ala Ile His Lys Ile Cys Ala Lys Leu Met Asn Ile Lys Gln Ile
             210                 215                 220

 tcc ttt agt gat atc aat caa gtc ctc gca cat cag ctg gga agt gtg     1020
 Ser Phe Ser Asp Ile Asn Gln Val Leu Ala His Gln Leu Gly Ser Val
         225                 230                 235

 ttc cag cct act tat tct gca gaa agc tca ttt cac tac aga cga aat     1068
 Phe Gln Pro Thr Tyr Ser Ala Glu Ser Ser Phe His Tyr Arg Arg Asn
     240                 245                 250

 cca cta gag gga ttt aaa gat cca gct ctg tat act tcc tgg ttg aag     1116
 Pro Leu Glu Gly Phe Lys Asp Pro Ala Leu Tyr Thr Ser Trp Leu Lys
 255                 260                 265                 270

 cct gtt aat gct ttc aac gtg tgg aaa acc cag cgg gcc ttt agc aaa     1164
 Pro Val Asn Ala Phe Asn Val Trp Lys Thr Gln Arg Ala Phe Ser Lys
                 275                 280                 285

 tat gag aag tct gca gtg ttg gtc agc aac agc cag ttc tta gta aaa     1212
 Tyr Glu Lys Ser Ala Val Leu Val Ser Asn Ser Gln Phe Leu Val Lys
             290                 295                 300

 cca ctt gat atg att gtt ggg aag gca tgg aat atg ttt gct tca aaa     1260
 Pro Leu Asp Met Ile Val Gly Lys Ala Trp Asn Met Phe Ala Ser Lys
         305                 310                 315

 gcc tac att cat cag tac aca aaa ttt gga atc gaa gaa gag gac ttt     1308
 Ala Tyr Ile His Gln Tyr Thr Lys Phe Gly Ile Glu Glu Glu Asp Phe
     320                 325                 330

 tta gac agt ttc acg tca tta gag cag gtt gtt gcc agt tac tgt aat     1356
 Leu Asp Ser Phe Thr Ser Leu Glu Gln Val Val Ala Ser Tyr Cys Asn
 335                 340                 345                 350

 ctc tgat cttgaacaat gggaaaagta taccttaagg catttctgga ctaaaatatt     1413
 Leu 


 ttcaatacta ttttctctgt aaagttttca aagttctcca tcctggctaa cacggtgaaa   1473

 caccgtctct accagaaaat acaaaaaatt agccaggcgc ggtggcgggt gcctgtagtc   1533

 ccagctactc gggaggctga ggcaggagaa tgacgtgaac ccaggaggcg gagcttgcag   1593

 tgagccgaga tcgcgccact gcactccagc ctgggcgaca gagcgagact ccgtctcaaa   1653

 aaaaaaaaa                                                           1662




      <210> 102
      <211> 3177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (916)..(1899)

      <400> 102
 acgcgtccgg gggaaatctc cttcagtgga agctgctgag tgtcgttggc ggaaagtatc     60

 ctggagccca gcaaaagcct ccaaagcact agagcttccc taaagaaaag cagaataaaa    120

 gaaagacaag aagggaagcc cgttcctcta aagcccgggt ttccaatagt cccggatcct    180

 cctggagttg ggcgaaggcg cagttggcag cagccgctgc tggcacccgg acttggaaag    240

 gcggtgttcc cccttttcgg gaggagggag gcagggactt gcaggcaaga gttgcacctg    300

 gtctaggaac ctgcagagaa aagaactctg gggagaagaa ctgccccgga gcgcagcagc    360

 caccctccga ccatgccccg gtgagggggg cggacttcga gggcaacttg ccgcggactg    420

 cctgggctta gccagcgagc tacgcgctcc cgggagcccg gaattgcacg gcgcagcccg    480

 gcggggggct atcgtctatg tcttcttggg gcgccagacg aatcggggtc tcgtttttgc    540

 tggaagagcc cagtgttggt ggcttcaggt ggctgctgcc gccgccgccg ccgccgccgc    600

 tgctagtgcg gtttccgccg ctggtgcgaa gagaagagac acgcgagcgg ggagacctcc    660

 aaggcagcga ggcatcggac atgtgtcagc acatctgggg cgcacatccg tcgagcccga    720

 ggggagattt gccggaacaa ttcaaactgc gatattgatc ttgggggtga ctgtccctgg    780

 ccggctgtcg ggtgggagtg cgagtgtgca ctcgctcgga agtgtgtgcg agtgtgtatg    840

 tgtgtgtgcc gtgtcgggct ccccccttcc ccccgttttc ccgtcgagtg atgcacttgg    900

 aatgagaatc agagg atg gaa ata gtc tgg gag gtg ctt ttt ctt ctt caa     951
                  Met Glu Ile Val Trp Glu Val Leu Phe Leu Leu Gln
                    1               5                  10

 gcc aat ttc atc gtc tgc ata tca gct caa cag aat tca cca aaa atc      999
 Ala Asn Phe Ile Val Cys Ile Ser Ala Gln Gln Asn Ser Pro Lys Ile
          15                  20                  25

 cat gaa ggc tgg tgg gca tac aag gag gtg gtc cag gga agc ttt gtt     1047
 His Glu Gly Trp Trp Ala Tyr Lys Glu Val Val Gln Gly Ser Phe Val
      30                  35                  40

 cca gtt cct tct ttc tgg gga ttg gtg aac tca gct tgg aat ctt tgc     1095
 Pro Val Pro Ser Phe Trp Gly Leu Val Asn Ser Ala Trp Asn Leu Cys
  45                  50                  55                  60

 tct gtg ggg aaa cgg cag tcg cca gtc aac ata gag acc agt cac atg     1143
 Ser Val Gly Lys Arg Gln Ser Pro Val Asn Ile Glu Thr Ser His Met
                  65                  70                  75

 atc ttc gac ccc ttt ctg aca cct ctt cgc atc aac acg ggg ggc agg     1191
 Ile Phe Asp Pro Phe Leu Thr Pro Leu Arg Ile Asn Thr Gly Gly Arg
              80                  85                  90

 aag gtc agt ggg acc atg tac aac act gga aga cac gta tcc ctt cgc     1239
 Lys Val Ser Gly Thr Met Tyr Asn Thr Gly Arg His Val Ser Leu Arg
          95                 100                 105

 ctg gac aag gag cac ttg gtc aac ata tct gga ggg ccc atg aca tac     1287
 Leu Asp Lys Glu His Leu Val Asn Ile Ser Gly Gly Pro Met Thr Tyr
     110                 115                 120

 agc cac cgg ctg gag gag atc cga cta cac ttt ggg agt gag gac agc     1335
 Ser His Arg Leu Glu Glu Ile Arg Leu His Phe Gly Ser Glu Asp Ser
 125                 130                 135                 140

 caa ggg tcg gag cac ctc ctc aat gga cag gcc ttc tct ggg gag gtg     1383
 Gln Gly Ser Glu His Leu Leu Asn Gly Gln Ala Phe Ser Gly Glu Val
                 145                 150                 155

 cag ctc atc cac tat aac cat gag cta tat acg aat gtc aca gaa gct     1431
 Gln Leu Ile His Tyr Asn His Glu Leu Tyr Thr Asn Val Thr Glu Ala
             160                 165                 170

 gca aag agt cca aat gga ttg gtg gta gtt tct ata ttt ata aaa gtt     1479
 Ala Lys Ser Pro Asn Gly Leu Val Val Val Ser Ile Phe Ile Lys Val
         175                 180                 185

 tct gat tca tca aac cca ttt ctt aat cga atg ctc aac aga gat act     1527
 Ser Asp Ser Ser Asn Pro Phe Leu Asn Arg Met Leu Asn Arg Asp Thr
     190                 195                 200

 atc aca aga ata aca tat aaa aat gat gca tat tta cta cag ggg ctt     1575
 Ile Thr Arg Ile Thr Tyr Lys Asn Asp Ala Tyr Leu Leu Gln Gly Leu
 205                 210                 215                 220

 aat ata gag gaa cta tat cca gag acc tct agt ttc atc act tac gat     1623
 Asn Ile Glu Glu Leu Tyr Pro Glu Thr Ser Ser Phe Ile Thr Tyr Asp
                 225                 230                 235

 ggg tcg atg act atc cca ccc tgc tat gag aca gca agt tgg atc ata     1671
 Gly Ser Met Thr Ile Pro Pro Cys Tyr Glu Thr Ala Ser Trp Ile Ile
             240                 245                 250

 atg aac aaa cct gtc tat ata acc agg atg cag atg cat tcc ttg cgc     1719
 Met Asn Lys Pro Val Tyr Ile Thr Arg Met Gln Met His Ser Leu Arg
         255                 260                 265

 ctg ctc agc cag aac cag cca tct cag atc ttt ctg agc atg agt gac     1767
 Leu Leu Ser Gln Asn Gln Pro Ser Gln Ile Phe Leu Ser Met Ser Asp
     270                 275                 280

 aac ttc agg cct gtc cag cca ctc aac aac cgc tgc atc cgc acc aat     1815
 Asn Phe Arg Pro Val Gln Pro Leu Asn Asn Arg Cys Ile Arg Thr Asn
 285                 290                 295                 300

 atc aac ttc agt tta cag ggg aag gac tgt cca aac aac cga gcc cag     1863
 Ile Asn Phe Ser Leu Gln Gly Lys Asp Cys Pro Asn Asn Arg Ala Gln
                 305                 310                 315

 aag ctt cag tat aga gta aat gaa tgg ctc ctc aag tagg gaacaaagcc     1913
 Lys Leu Gln Tyr Arg Val Asn Glu Trp Leu Leu Lys 
             320                 325

 aagaagaatc ccacctcagt gaaatgctac aactgtgaat tgacgtaacc tagaatgtcc   1973

 cccttcttgc ttctctctcc ttctttcccc caagcctcat tcattcttgg gattggccct   2033

 ttcttcatga aaagtgtctg caaaaccatg gcagaggaat acatctctca cacatactca   2093

 caaacacaca cacaagcact tgcacataca tacaaacaca tgcaaacata cctacacaca   2153

 cacacactct tacaacctcc atcatgggaa gtcaagtttc agaaacaaaa gtctcattca   2213

 taagaggtct tagaagaaaa taaccagtta acctgatttc aattttgata ccgttttcct   2273

 gaactaataa atctacccaa tgagactttt cagcctttgt acatacaaaa ttcttccaaa   2333

 agagagagga gaaaatacag ctctgatggc atcaaacgga ctttgcatca agtaatttca   2393

 gatagtgtcc taggatcctt tgagggtgct ggtagcaggt gagcaggaca aagttgacca   2453

 aggacactta tttctagatt atgattcttc tgtttactca acaatttaca aagaaaaaaa   2513

 ggacagacat tgaagagcta cacattgtat atatatcacc acagactata aggaaatgga   2573

 attatttccc tctttgtcac atatctgtag taggatttgc caagatcaga aatgatccat   2633

 ttgctgtttc ttgttttcca aaggtcatac attgtgtttg gttattgtta ccagctcaat   2693

 aaatgtgttt aacgagttaa tttcattttt ctggctttgg tctgttctcc ttccttacag   2753

 gctaagccct ggctccatgc aactgcattc tttgatttca cttgttcctt catctacatg   2813

 ttttgttcat ttgcagccag tttttactga gtttgtggca atcaggaatg catttgctaa   2873

 gcaagtatga ctttaattcc actccatggc tcaatcattc acatgaggtg agcttcagcc   2933

 tgagatagca ggcgacagac ttcttgcgtt tcaaaactgc catgcccccc tgtgatgctc   2993

 ccgtgaagga atgcactttg ccttgtaagt tcctgggaaa ggggtatgtt ttctctccag   3053

 gtgcagccag atctcacaaa gtacaaaacg aatgcctttc ttttcttgtt tataatggtc   3113

 actcactgtg tttggttact gtcaagaaat caataaatgt gtttaacaag ttaaaaaaaa   3173

 aaaa                                                                3177




      <210> 103
      <211> 704
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (257)..(523)

      <400> 103
 tgtcttgtta tttctttttt tggggggttt cttctgtttc ttttttctgc ctatttttgg     60

 attaactgaa tattttttag tgttatgttt tattaattgg cttttggtta tatctgcgct    120

 atgtttttgc tgtaggaatt acaaaatata tacctaacct acctacttag agttagcatt    180

 ttacctctaa ataaaatgta aaagtattgc aaacatatag gtttctttat tctagccccc    240

 ccttataatt gaatat    atg tgg ggg ggg atg tgt gta tat atc tat ata     289
                      Met Trp Gly Gly Met Cys Val Tyr Ile Tyr Ile
                        1               5                  10

 cac ttt caa tgg atg gag ata tgt atc tat act ttc agt gta tat tat      337
 His Phe Gln Trp Met Glu Ile Cys Ile Tyr Thr Phe Ser Val Tyr Tyr
              15                  20                  25

 atc tac atg cat aca ttg tgt atg tat gta gat gta tat cta cat aca      385
 Ile Tyr Met His Thr Leu Cys Met Tyr Val Asp Val Tyr Leu His Thr
          30                  35                  40

 ttg aaa gat ata tat cta cat act ata caa tgc atg tat gat acc ttt      433
 Leu Lys Asp Ile Tyr Leu His Thr Ile Gln Cys Met Tyr Asp Thr Phe
      45                  50                  55

 ggc tac tac atc ctt ctt aaa ttt cct gtt gcc act tat gac ctg att      481
 Gly Tyr Tyr Ile Leu Leu Lys Phe Pro Val Ala Thr Tyr Asp Leu Ile
  60                  65                  70                  75

 tcc ttg acc agt tat tcc tcc ttc aaa cat ccc tct tac atg tgatagt      530
 Ser Leu Thr Ser Tyr Ser Ser Phe Lys His Pro Ser Tyr Met 
                  80                  85

 cctcagcatt tagtttcccc aactttcccc taattatcag ttgactcaat taccaccaaa    590

 atatcaatga cttttttgag acagagtctc actctgtcac caggctggag tgcagtggca    650

 cgatcttggc tcagtgcaac ctctgcctcc tgagtccaag tgattctcct ccct          704




      <210> 104
      <211> 1069
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(717)

      <400> 104
 cgcgtccgcc cacgcgtccg cgcacgcttg gtgcgtgcgc ggcgactgcg acgggcagtg     60

 gcagtc   atg gcg gct cag tgc gtg agg ttg gcg cgg cgc agt ctt cct     108
          Met Ala Ala Gln Cys Val Arg Leu Ala Arg Arg Ser Leu Pro
            1               5                  10

 gct ttg gcg ttg tct ctc agg cca tct ccc cgg ttg ttg tgc aca gcc      156
 Ala Leu Ala Leu Ser Leu Arg Pro Ser Pro Arg Leu Leu Cys Thr Ala
  15                  20                  25                  30

 acg aaa caa aag aac agt ggc cag aac ctg gaa gag gac atg ggt cag      204
 Thr Lys Gln Lys Asn Ser Gly Gln Asn Leu Glu Glu Asp Met Gly Gln
                  35                  40                  45

 agt gaa cag aag gca gat cct cct gct aca gag aag acc ctc ctg gaa      252
 Ser Glu Gln Lys Ala Asp Pro Pro Ala Thr Glu Lys Thr Leu Leu Glu
              50                  55                  60

 gag aag gtc aag ttg gag gaa cag ctg aag gag act gtg gaa aaa tat      300
 Glu Lys Val Lys Leu Glu Glu Gln Leu Lys Glu Thr Val Glu Lys Tyr
          65                  70                  75

 aaa cga gct ttg gca gac act gag aac tta cgg cag agg agc cag aaa      348
 Lys Arg Ala Leu Ala Asp Thr Glu Asn Leu Arg Gln Arg Ser Gln Lys
      80                  85                  90

 ttg gtg gag gag gca aaa tta tac ggc att caa gcc ttc tgc aag gac      396
 Leu Val Glu Glu Ala Lys Leu Tyr Gly Ile Gln Ala Phe Cys Lys Asp
  95                 100                 105                 110

 ttg ttg gag gtg gca gac gtt ctg gag aag gca aca cag tgt gtt cca      444
 Leu Leu Glu Val Ala Asp Val Leu Glu Lys Ala Thr Gln Cys Val Pro
                 115                 120                 125

 aaa gaa gaa att aaa gac gat aac cct cac ctg aag aac ctc tat gag      492
 Lys Glu Glu Ile Lys Asp Asp Asn Pro His Leu Lys Asn Leu Tyr Glu
             130                 135                 140

 ggg ctg gtc atg act gaa gtc cag atc cag aag gtg ttc aca aag cat      540
 Gly Leu Val Met Thr Glu Val Gln Ile Gln Lys Val Phe Thr Lys His
         145                 150                 155

 ggc ttg ctc aag ttg aac cct gtc gga gcc aag ttc gac cct tat gaa      588
 Gly Leu Leu Lys Leu Asn Pro Val Gly Ala Lys Phe Asp Pro Tyr Glu
     160                 165                 170

 cat gag gcc ttg ttc cac aca ccg gtt gag ggg aag gag cca ggc aca      636
 His Glu Ala Leu Phe His Thr Pro Val Glu Gly Lys Glu Pro Gly Thr
 175                 180                 185                 190

 gtg gcc cta gtt agc aaa gtg ggg tac aag ctg cat ggg cgc act ctg      684
 Val Ala Leu Val Ser Lys Val Gly Tyr Lys Leu His Gly Arg Thr Leu
                 195                 200                 205

 aga ccc gcc ctg gtg ggg gtg gtg aag gaa gct tagctgct gttgatgggg      735
 Arg Pro Ala Leu Val Gly Val Val Lys Glu Ala 
             210                 215

 tgggtgtttt taaactcact tgatgtaact ctcaaggctg gttcattgtt tctcatctat    795

 gagtacgtgt gaccttttcc caaaccttat tggaaacctt aagtaaccag tggctaaaca    855

 gaaaagccgg ttgcccaact gcattaatga actctaattc gggagtctgt tcccttttag    915

 tgccacgcgt tgaatagttc cacatacttt cagaagagct cagcagggcc ctgcctggtc    975

 tcccgagcat catgagtaac gtgtctgctc agactctgct gacaccaaag tattttaaac   1035

 aaataaaagg tcttggggaa aaaaaaaaaa aaaa                               1069




      <210> 105
      <211> 2322
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (752)..(931)

      <400> 105
 gaattccctc ttcgacccac gcgtccggca aggtcaagtc tggatgatta ctgtccttct     60

 gaccaagttg attctattca tgaaaaggtc ctcaatatgc tacgtgccct ctatggaaat    120

 ctagacctcc aagtgtatgc agcagagtct cctccatctt gaaacaaaca aaacattagg    180

 ctcctgttgt atcttggttt agtaacaggc ccttaattaa cttatttgta catgagtctt    240

 ccagagaaca ctgttttata ttaactttca gttgaaatct ttcagatatt ttgaatctct    300

 gaacaaccat tgtcagttgt gaatgatggt aaattttttg gcatcaagtc tcataacccc    360

 aactgataga actgttgctt atctgtcttc cttaagtatt ttttagggtt ttgttttttt    420

 ttttgtttgt ttgtttgttt gtcttcactt ttcccccagg gtctgttgag ctgtatgaga    480

 ttcattcata cttcatttat tcattcaact aatatttgtt gaacacttac atgtaccaga    540

 cattattaag tgctgggtat atggtaatga acagaataga caaggcccct gcccttttag    600

 gggagacaga tgagaagtaa attccgggtt atgagaaatg ttatgaagga aaggacaaca    660

 acagacatgt cttagtactt agggtatcat ggctttatag gaaagtaaca ttctctatct    720

 tttttttttt tttaatttta taaaaataga g   atg ggg tct cac cat gtt acc     772
                                      Met Gly Ser His His Val Thr
                                        1               5

 cag gct ggt ctc aaa ctc ctg ggc aca agc aat cca cct gcc ttc gcc      820
 Gln Ala Gly Leu Lys Leu Leu Gly Thr Ser Asn Pro Pro Ala Phe Ala
          10                  15                  20

 tcc cga agt gct ggg att aca gat gta agt cac tac ccc agc cag aaa      868
 Ser Arg Ser Ala Gly Ile Thr Asp Val Ser His Tyr Pro Ser Gln Lys
      25                  30                  35

 cta aca ttc tca aaa gct act acc aaa aaa acc cca caa att tgc caa      916
 Leu Thr Phe Ser Lys Ala Thr Thr Lys Lys Thr Pro Gln Ile Cys Gln
  40                  45                  50                  55

 tcc atg aaa gta tca taggaagtct acctttccaa ggaatttggc attgtggccc      971
 Ser Met Lys Val Ser 
                  60

 tgctcttgcc aaatgctctc cagcattgtt ggtatcaagg tggtctggtt gagtaaactt   1031

 gaccaaacaa aaattaactg ttttttgctt ttctgttttt gttttgctga tcaaaaaagc   1091

 ccttcagggt cttttgtgca tccaggaggt cattgtagat atcaataata tagtgcctaa   1151

 gtgccacttt attgccaagt ctagattgat acttttttca gataaaccag ctttttatgt   1211

 aaagagtaag ggaaaaagtt aaatctttaa ttctgacctg ccataaatac ccaaagatat   1271

 aaactgtctt ccaccacccc cctcataact aagacatcct tcctgagtca ctcttaatca   1331

 tgaaacttga ttttctcaat tggccagtct tctgatcttt agtatctctt tagttcagta   1391

 atttttacct acctacttga tttattttcc tttaaaaggt gaaatgacat ttaaagaaaa   1451

 acaaacaccc atcattcctc agtcccaaca cagcagttct tttcactctt gcttgtaact   1511

 ttcaggcctt acccacatgt gttcctatag agttgcatgt agctaaaatt atagtgtgct   1571

 gcctaacttt gtgctaataa cgaaggacac acattatcat tgcctcacag tggatggcac   1631

 ctgaccccat ttttccaagg attctatttt ccagtgaatt tttgtcaccg agttaatttc   1691

 ccaagtctga tagcatgaat gcttatttgt gctgtgaaaa gcagagcagc ctgagtcagc   1751

 tttccatttt cataggataa tatgtgccaa aaaaggttta ttttcttggt aaaatcagaa   1811

 ttgtagaatt gtgctatttt taatttttaa aatttttggt tagagcttat agacattact   1871

 tttatgatta ttttgcgtgc taaataagtt aaagggtatg ttttgaacta tagcactaat   1931

 taatgtgtgt gatcctagta tgttgatagc tttgattttg tgagtggttt actagtcatt   1991

 tattatgatt cccatgaact ctgatatgat tcattgtggt tttaactcag gttgaataaa   2051

 agcatccatt tcttttatag gaaggtttgt ttaattctca tgttctgtga tcatctcttt   2111

 gagaataaaa ttcagtccct aatagttgaa aagaatcaac ttagtaaatt atgtcttgca   2171

 cattccaaat aggaaggtat ttactttatc aagatgtgtt tcatttgtgt tctgagtacc   2231

 agtgagggga taccgtggta cagtgttttg aattgtgtac taatatcatt aaagcatggg   2291

 attttagtgg ctttttaaaa aatgtgaaaa a                                  2322




      <210> 106
      <211> 1576
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(1573)

      <400> 106
 ggaagctgcc ccgtccaggt tc atg ttc ctc tta ttt ctc ctc acg tgt gag      52
                          Met Phe Leu Leu Phe Leu Leu Thr Cys Glu
                            1               5                  10

 ctg gct gca gaa gtt gct gca gaa gtt gag aaa tcc tca gat ggt cct      100
 Leu Ala Ala Glu Val Ala Ala Glu Val Glu Lys Ser Ser Asp Gly Pro
                  15                  20                  25

 ggt gct gcc cag gaa ccc acg tgg ctc aca gat gtc cca gct gcc atg      148
 Gly Ala Ala Gln Glu Pro Thr Trp Leu Thr Asp Val Pro Ala Ala Met
              30                  35                  40

 gaa ttc att gct gcc act gag gtg gct gtc ata ggc ttc ttc cag gat      196
 Glu Phe Ile Ala Ala Thr Glu Val Ala Val Ile Gly Phe Phe Gln Asp
          45                  50                  55

 tta gaa ata cca gca gtg ccc ata ctc cat agc atg gtg caa aaa ttc      244
 Leu Glu Ile Pro Ala Val Pro Ile Leu His Ser Met Val Gln Lys Phe
      60                  65                  70

 cca ggc gtg tca ttt ggg atc agc act gat tct gag gtt ctg aca cac      292
 Pro Gly Val Ser Phe Gly Ile Ser Thr Asp Ser Glu Val Leu Thr His
  75                  80                  85                  90

 tac aac atc act ggg aac acc atc tgc ctc ttt cgc ctg gta gac aat      340
 Tyr Asn Ile Thr Gly Asn Thr Ile Cys Leu Phe Arg Leu Val Asp Asn
                  95                 100                 105

 gaa caa ctg aat tta gag gac gaa gac att gaa agc att gat gcc acc      388
 Glu Gln Leu Asn Leu Glu Asp Glu Asp Ile Glu Ser Ile Asp Ala Thr
             110                 115                 120

 aaa ttg agc cgt ttc att gag atc aac agc ctc cac atg gtg aca gag      436
 Lys Leu Ser Arg Phe Ile Glu Ile Asn Ser Leu His Met Val Thr Glu
         125                 130                 135

 tac aac cct gtg ggt ggg aag gaa gga tct aca cag ttg cat gaa aac      484
 Tyr Asn Pro Val Gly Gly Lys Glu Gly Ser Thr Gln Leu His Glu Asn
     140                 145                 150

 gag atg act gtg att ggg tta ttc aac agc gta att cag att cat ctc      532
 Glu Met Thr Val Ile Gly Leu Phe Asn Ser Val Ile Gln Ile His Leu
 155                 160                 165                 170

 ctc ctg ata atg aac aag gcc tcc cca gag tat gaa gag aac atg cac      580
 Leu Leu Ile Met Asn Lys Ala Ser Pro Glu Tyr Glu Glu Asn Met His
                 175                 180                 185

 aga tac cag aag gca gcc aag ctc ttc cag ggg aag att ctc ttt att      628
 Arg Tyr Gln Lys Ala Ala Lys Leu Phe Gln Gly Lys Ile Leu Phe Ile
             190                 195                 200

 ctg gtg gac agt ggt atg aaa gaa aat ggg aag gtg ata tca ttt ttc      676
 Leu Val Asp Ser Gly Met Lys Glu Asn Gly Lys Val Ile Ser Phe Phe
         205                 210                 215

 aaa cta aag gag tct caa ctg cca gct ttg gca att tac cag act cta      724
 Lys Leu Lys Glu Ser Gln Leu Pro Ala Leu Ala Ile Tyr Gln Thr Leu
     220                 225                 230

 gat gac gag tgg gat aca ctg ccc aca gca gaa gtt tcc gta gag cat      772
 Asp Asp Glu Trp Asp Thr Leu Pro Thr Ala Glu Val Ser Val Glu His
 235                 240                 245                 250

 gtg caa aac ttt tgt gat gga ttc cta agt gga aaa ttg ttg aaa cct      820
 Val Gln Asn Phe Cys Asp Gly Phe Leu Ser Gly Lys Leu Leu Lys Pro
                 255                 260                 265

 tac atg gcg aga cct aga gaa ttg gaa aag gag aaa gtt aaa cac gaa      868
 Tyr Met Ala Arg Pro Arg Glu Leu Glu Lys Glu Lys Val Lys His Glu
             270                 275                 280

 cac ctt ttg agt gtt gaa ctt ttg gaa aaa agc cct tgg aat ccg gga      916
 His Leu Leu Ser Val Glu Leu Leu Glu Lys Ser Pro Trp Asn Pro Gly
         285                 290                 295

 ctc caa cat gca atg att gcc cca gat ctc tgt act aca cct gac cac      964
 Leu Gln His Ala Met Ile Ala Pro Asp Leu Cys Thr Thr Pro Asp His
     300                 305                 310

 ttt ctg aaa tat ttg aag ccg agg ata cag gaa gtt ctt aaa gcc agt     1012
 Phe Leu Lys Tyr Leu Lys Pro Arg Ile Gln Glu Val Leu Lys Ala Ser
 315                 320                 325                 330

 ctg gct ctg ggg atg atc gca gaa acc cta aga gaa tta tct gag ctg     1060
 Leu Ala Leu Gly Met Ile Ala Glu Thr Leu Arg Glu Leu Ser Glu Leu
                 335                 340                 345

 gtc act agc acc ttt ctt gat gct ttg gaa aca gag atg ctc ctg agt     1108
 Val Thr Ser Thr Phe Leu Asp Ala Leu Glu Thr Glu Met Leu Leu Ser
             350                 355                 360

 gcc cat aag aat ggt cag ccc aga gcc tct ctc cct act gct gct aca     1156
 Ala His Lys Asn Gly Gln Pro Arg Ala Ser Leu Pro Thr Ala Ala Thr
         365                 370                 375

 caa gac cct gag act gac ctg cag gac gaa acc atg aag agc ctg atc     1204
 Gln Asp Pro Glu Thr Asp Leu Gln Asp Glu Thr Met Lys Ser Leu Ile
     380                 385                 390

 ctt ctt gcc atc ctg gcc gcc tta gcg gta gta act ttg tgt tat gga     1252
 Leu Leu Ala Ile Leu Ala Ala Leu Ala Val Val Thr Leu Cys Tyr Gly
 395                 400                 405                 410

 gag tgg cag aaa gaa gaa aac ttc ggc ttt gat atc gtt tca gtt ctc     1300
 Glu Trp Gln Lys Glu Glu Asn Phe Gly Phe Asp Ile Val Ser Val Leu
                 415                 420                 425

 tct ctg aac tgg cat cgt gcc cag gaa tca cat gaa agc atg gaa tct     1348
 Ser Leu Asn Trp His Arg Ala Gln Glu Ser His Glu Ser Met Glu Ser
             430                 435                 440

 tat gaa ctt aat ccc ttc att aac agg aga aat gca aat acc ttc ata     1396
 Tyr Glu Leu Asn Pro Phe Ile Asn Arg Arg Asn Ala Asn Thr Phe Ile
         445                 450                 455

 tcc cct cag cag aga tgg aga gct aaa gtc caa gag agg atc cga gaa     1444
 Ser Pro Gln Gln Arg Trp Arg Ala Lys Val Gln Glu Arg Ile Arg Glu
     460                 465                 470

 cgc tct aag cct gtc cac gag ctc aat agg gaa gcc tgt gat gac tac     1492
 Arg Ser Lys Pro Val His Glu Leu Asn Arg Glu Ala Cys Asp Asp Tyr
 475                 480                 485                 490

 aga ctt tgc gaa cgc tac gcc atg gtt tat gga tac aat gct gcc tat     1540
 Arg Leu Cys Glu Arg Tyr Ala Met Val Tyr Gly Tyr Asn Ala Ala Tyr
                 495                 500                 505

 aat cgc tac ttc agg aag cgc cga ggg acc aaa tga                     1576
 Asn Arg Tyr Phe Arg Lys Arg Arg Gly Thr Lys 
             510                 515





      <210> 107
      <211> 642
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(237)

      <400> 107
 caatcttagt ttgcctccag ttaatctttt atgcttaggg attaa    atg tgt ggt      54
                                                      Met Cys Gly
                                                        1

 ttt ttt ttt gtt ttt ttt ttt tgg aga cgg agt ctc gct ctg tca ccc      102
 Phe Phe Phe Val Phe Phe Phe Trp Arg Arg Ser Leu Ala Leu Ser Pro
       5                  10                  15

 agg ctg gag tgc agt ggc gcg atc tcg gct cac tgc aac ctc tgc ctc      150
 Arg Leu Glu Cys Ser Gly Ala Ile Ser Ala His Cys Asn Leu Cys Leu
  20                  25                  30                  35

 ctg ggt tca aac gat tct cct gcc tca gcc tcc caa gta gct ggg att      198
 Leu Gly Ser Asn Asp Ser Pro Ala Ser Ala Ser Gln Val Ala Gly Ile
                  40                  45                  50

 ata ggc gcc cac cac cat gcc tgg ctg att ttt tat ttt tagtagagat       247
 Ile Gly Ala His His His Ala Trp Leu Ile Phe Tyr Phe 
              55                  60

 ggggtttcac cgtgttggcc aggctggtct cgaactcctg acctcgtgat ctacccacct    307

 cggcctcccc aagtgctggg attacaggcg tgagctagca tgcctggcca gggattaaaa    367

 tattcaaaca tgttgtgtgt acccagatat gctgttaatt taggaaaaac agtacaattt    427

 ctatgaagtg gttgtgacta ttttctgtag tcaatacagt tgggatatct gatctatttc    487

 tctgtctact ttggaaatga ttgcataata aataaaattt tactgttttt ttaaaaaaaa    547

 aacagaggtg atacaagcag agggggttcc agtggaattg ctaggctgac gggcgaggtg    607

 cgtgttcagg ggtttaagta tgcctctgga gggtt                               642




      <210> 108
      <211> 2341
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (228)..(2024)

      <400> 108
 cacgcgtccg gcaaggccct gtgagcggga ggactgggat cccggccgcg gctgctggaa     60

 gcgtcgaagc tcagcggggc cgcggacact gacctgtgct tagaactcat cctggcccgc    120

 agagcctgcc gcgagtccct ggcgtcccct gtggcgggct cttggagcca ctttcccgag    180

 cggaagtcag cccgcggctc ggactccggc gggacctgct cggagga  atg gcg ccg     236
                                                      Met Ala Pro
                                                        1

 ccg ggt tca agc act gtc ttc ctg ttg gcc ctg aca atc ata gcc agc      284
 Pro Gly Ser Ser Thr Val Phe Leu Leu Ala Leu Thr Ile Ile Ala Ser
       5                  10                  15

 acc tgg gct ctg acg ccc act cac tac ctc acc aag cat gac gtg gag      332
 Thr Trp Ala Leu Thr Pro Thr His Tyr Leu Thr Lys His Asp Val Glu
  20                  25                  30                  35

 aga cta aaa gcc tcg ctg gat cgc cct ttc aca aat ttg gaa tct gcc      380
 Arg Leu Lys Ala Ser Leu Asp Arg Pro Phe Thr Asn Leu Glu Ser Ala
                  40                  45                  50

 ttc tac tcc atc gtg gga ctc agc agc ctt ggt gct cag gtg cca gat      428
 Phe Tyr Ser Ile Val Gly Leu Ser Ser Leu Gly Ala Gln Val Pro Asp
              55                  60                  65

 gca aag aaa gca tgt acc tac atc aga tct aac ctt gat ccc agc aat      476
 Ala Lys Lys Ala Cys Thr Tyr Ile Arg Ser Asn Leu Asp Pro Ser Asn
          70                  75                  80

 gtg gat tcc ctc ttc tac gct gcc cag gcc agc cag gcc ctc tca gga      524
 Val Asp Ser Leu Phe Tyr Ala Ala Gln Ala Ser Gln Ala Leu Ser Gly
      85                  90                  95

 tgt gag atc tct att tca aat gag acc aaa gat ctg ctt ctg gca gct      572
 Cys Glu Ile Ser Ile Ser Asn Glu Thr Lys Asp Leu Leu Leu Ala Ala
 100                 105                 110                 115

 gtc agt gag gac tca tct gtt acc cag atc tac cat gca gtt gca gct      620
 Val Ser Glu Asp Ser Ser Val Thr Gln Ile Tyr His Ala Val Ala Ala
                 120                 125                 130

 cta agt ggc ttt ggc ctt ccc ttg gca tcc caa gaa gca ctc agt gcc      668
 Leu Ser Gly Phe Gly Leu Pro Leu Ala Ser Gln Glu Ala Leu Ser Ala
             135                 140                 145

 ctt act gct cgt ctc agc aag gag gag act gtg ctg gca aca gtc cag      716
 Leu Thr Ala Arg Leu Ser Lys Glu Glu Thr Val Leu Ala Thr Val Gln
         150                 155                 160

 gct ctg cag aca gca tcc cac ctg tcc cag cag gct gac ctg agg agc      764
 Ala Leu Gln Thr Ala Ser His Leu Ser Gln Gln Ala Asp Leu Arg Ser
     165                 170                 175

 atc gtg gag gag att gag gac ctt gtt gct cgc ctg gat gaa ctc ggg      812
 Ile Val Glu Glu Ile Glu Asp Leu Val Ala Arg Leu Asp Glu Leu Gly
 180                 185                 190                 195

 ggc gtg tat ctc cag ttt gaa gaa gga ctg gaa aca aca gcg tta ttt      860
 Gly Val Tyr Leu Gln Phe Glu Glu Gly Leu Glu Thr Thr Ala Leu Phe
                 200                 205                 210

 gtg gct gcc acc tac aag ctc atg gat cat gtg ggg act gag cca tcc      908
 Val Ala Ala Thr Tyr Lys Leu Met Asp His Val Gly Thr Glu Pro Ser
             215                 220                 225

 att aag gag gat cag gtc atc cag ctg atg aac gcg atc ttc agc aag      956
 Ile Lys Glu Asp Gln Val Ile Gln Leu Met Asn Ala Ile Phe Ser Lys
         230                 235                 240

 aag aac ttt gag tcc ctc tcc gaa gcc ttc agc gtg gcc tct gca gct     1004
 Lys Asn Phe Glu Ser Leu Ser Glu Ala Phe Ser Val Ala Ser Ala Ala
     245                 250                 255

 gct gtg ctc tcg cat aat cgc tac cac gtg cca gtt gtg gtt gtg cct     1052
 Ala Val Leu Ser His Asn Arg Tyr His Val Pro Val Val Val Val Pro
 260                 265                 270                 275

 gag ggc tct gct tcc gac act cat gaa cag gct atc ttg cgg ttg caa     1100
 Glu Gly Ser Ala Ser Asp Thr His Glu Gln Ala Ile Leu Arg Leu Gln
                 280                 285                 290

 gtc acc aat gtt ctg tct cag cct ctg act cag gcc act gtt aaa cta     1148
 Val Thr Asn Val Leu Ser Gln Pro Leu Thr Gln Ala Thr Val Lys Leu
             295                 300                 305

 gaa cat gct aaa tct gtt gct tcc aga gcc act gtc ctc cag aag aca     1196
 Glu His Ala Lys Ser Val Ala Ser Arg Ala Thr Val Leu Gln Lys Thr
         310                 315                 320

 tcc ttc acc cct gta ggg gat gtt ttt gaa cta aat ttc atg aac gtc     1244
 Ser Phe Thr Pro Val Gly Asp Val Phe Glu Leu Asn Phe Met Asn Val
     325                 330                 335

 aaa ttt tcc agt ggt tat tat gac ttc ctt gtc gaa gtt gaa ggt gac     1292
 Lys Phe Ser Ser Gly Tyr Tyr Asp Phe Leu Val Glu Val Glu Gly Asp
 340                 345                 350                 355

 aac cgg tat att gca aat acc gta gag ctc aga gtc aag atc tcc act     1340
 Asn Arg Tyr Ile Ala Asn Thr Val Glu Leu Arg Val Lys Ile Ser Thr
                 360                 365                 370

 gaa gtt ggc atc aca aat gtt gat ctt tcc acc gtg gat aag gat cag     1388
 Glu Val Gly Ile Thr Asn Val Asp Leu Ser Thr Val Asp Lys Asp Gln
             375                 380                 385

 agc att gca ccc aaa act acc cgg gtg aca tac cca gcc aaa gcc aag     1436
 Ser Ile Ala Pro Lys Thr Thr Arg Val Thr Tyr Pro Ala Lys Ala Lys
         390                 395                 400

 ggc aca ttc atc gca gac agc cac cag aac ttc gcc ttg ttc ttc cag     1484
 Gly Thr Phe Ile Ala Asp Ser His Gln Asn Phe Ala Leu Phe Phe Gln
     405                 410                 415

 ctg gta gat gtg aac act ggt gct gaa ctc act cct cac cag aca ttt     1532
 Leu Val Asp Val Asn Thr Gly Ala Glu Leu Thr Pro His Gln Thr Phe
 420                 425                 430                 435

 gtc cga ctc cat aac cag aag act ggc cag gaa gtg gtg ttt gtt gcc     1580
 Val Arg Leu His Asn Gln Lys Thr Gly Gln Glu Val Val Phe Val Ala
                 440                 445                 450

 gag cca gac aac aag aac gtg tac aag ttt gaa ctg gat acc tct gaa     1628
 Glu Pro Asp Asn Lys Asn Val Tyr Lys Phe Glu Leu Asp Thr Ser Glu
             455                 460                 465

 aga aag att gaa ttt gac tct gcc tct ggc acc tac act ctc tac tta     1676
 Arg Lys Ile Glu Phe Asp Ser Ala Ser Gly Thr Tyr Thr Leu Tyr Leu
         470                 475                 480

 atc att gga gat gcc act ttg aag aac cca atc ctc tgg aat gtg gct     1724
 Ile Ile Gly Asp Ala Thr Leu Lys Asn Pro Ile Leu Trp Asn Val Ala
     485                 490                 495

 gat gtg gtc atc aag ttc cct gag gaa gaa gct ccc tcg act gtc ttg     1772
 Asp Val Val Ile Lys Phe Pro Glu Glu Glu Ala Pro Ser Thr Val Leu
 500                 505                 510                 515

 tcc cag aac ctt ttc act cca aaa cag gaa att cag tgg atc cgg att     1820
 Ser Gln Asn Leu Phe Thr Pro Lys Gln Glu Ile Gln Trp Ile Arg Ile
                 520                 525                 530

 ggt gcc aat gtc tcc aac ttc act ttt gct cct agc acg att ata ttt     1868
 Gly Ala Asn Val Ser Asn Phe Thr Phe Ala Pro Ser Thr Ile Ile Phe
             535                 540                 545

 cac ctg gga cat gct gct atg ctg gga ctc atg tat gtc tac tgg act     1916
 His Leu Gly His Ala Ala Met Leu Gly Leu Met Tyr Val Tyr Trp Thr
         550                 555                 560

 cag ctc aac atg ttc cag acc ttg aag tac ctg gcc atc ttg ggc agt     1964
 Gln Leu Asn Met Phe Gln Thr Leu Lys Tyr Leu Ala Ile Leu Gly Ser
     565                 570                 575

 gtg acg ttt ctg gct ggc aat cgg atg ctg gcc cag cag gca gtc aag     2012
 Val Thr Phe Leu Ala Gly Asn Arg Met Leu Ala Gln Gln Ala Val Lys
 580                 585                 590                 595

 aga aca gca cat tag ttccagaaga aagatggaaa ttctgaaaac tgaatgtcaa     2067
 Arg Thr Ala His 


 gaaaaggagt caagaacaat tcacagtatg agaagaaaaa tggaaaaaaa aaactttatt   2127

 taaaaaagaa aaaagtccag attgtagtta tacttttgct tgtttttcag tttccccaac   2187

 acacagcaga tacctggtga gctcagatag tctctttctc tgacactgtg taagaagctg   2247

 tgaatattcc taacttaccc agatgttgct tttgaaaagt tgaaatgtgt aattgttttg   2307

 gaataaagag ggtaacaata ggaaaaaaaa aaaa                               2341




      <210> 109
      <211> 910
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (352)..(771)

      <400> 109
 gccccatggg acagggtctc cactcctgag actcatggga ttagactagg cctacctgga     60

 tgatctggga tcctctccca tgtccaggtc tctatcccta accacatcag caaagtctct    120

 tttgccatgg aaggtatttg caggctctga ctttgtgtgt attagggcag gacatttttg    180

 gcggggcagt ggtgggggca gggaattatt ctgcctacca tgccttatac aaaaataaat    240

 aaatcacagg cttatacctg aaagaattcc tgcaaataat aaaagaatta gagcagctca    300

 gttaaataaa aaaaggtatg agatgtgaac agacacttca cagaagatga c atg cag     357
                                                          Met Gln
                                                            1

 ggg agc aag gta ttt atc aaa aag tgc tcc act ttt cac tta cca gag      405
 Gly Ser Lys Val Phe Ile Lys Lys Cys Ser Thr Phe His Leu Pro Glu
           5                  10                  15

 aaa tgc aaa tca gca ccc aaa gga gtc act gcg gca ccc tca tct gag      453
 Lys Cys Lys Ser Ala Pro Lys Gly Val Thr Ala Ala Pro Ser Ser Glu
      20                  25                  30

 cct cag aag tta gaa aga tgg ata gca cca gtg tca aag gtg act gtg      501
 Pro Gln Lys Leu Glu Arg Trp Ile Ala Pro Val Ser Lys Val Thr Val
  35                  40                  45                  50

 gga ggg aga ttt gca tac act gct agt aac aat gcg aaa ttg atg gaa      549
 Gly Gly Arg Phe Ala Tyr Thr Ala Ser Asn Asn Ala Lys Leu Met Glu
                  55                  60                  65

 cca acc tgg aaa atg gct tgg cat caa ctg ttg gag aag aag aca cac      597
 Pro Thr Trp Lys Met Ala Trp His Gln Leu Leu Glu Lys Lys Thr His
              70                  75                  80

 agt cct cta acc tgc cag tcc cac atc agg gcc tgg ata tgg ccg tca      645
 Ser Pro Leu Thr Cys Gln Ser His Ile Arg Ala Trp Ile Trp Pro Ser
          85                  90                  95

 tgt gta cca ggg agc atg gcc agg aat ctt tac agc caa ata ctc acc      693
 Cys Val Pro Gly Ser Met Ala Arg Asn Leu Tyr Ser Gln Ile Leu Thr
     100                 105                 110

 ata gca cca aac tgg aat cag ccg aca tac cca tca gga aga gaa tgg      741
 Ile Ala Pro Asn Trp Asn Gln Pro Thr Tyr Pro Ser Gly Arg Glu Trp
 115                 120                 125                 130

 atg tta aaa aat gca agg ata gcc att ggg t agaacgccat acagccatga      792
 Met Leu Lys Asn Ala Arg Ile Ala Ile Gly 
                 135                 140

 caattacaca gtgacaccta cacacaagga gcatgagtct cacaaacatg gcagcaaaag    852

 gagcctgttc aagagggtat gtgctatgga ttccattgta gataaagttt ttcaaaag      910




      <210> 110
      <211> 1755
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (338)..(1303)

      <400> 110
 aaacaagaaa acaaaaaaca caacatgaaa gaagagacaa caagaagacc aacaagaaga     60

 atagaagaga caaaagaaag agagagagaa ggagaagaga gaagacacag acaatgtcgg    120

 gtcctgaggg aaagtaccca cgaccaagct aatgatgttg ttgacgttga tggaaagtgc    180

 atcaagaacg caattacgta ctttagtcat gttacgccga tcatgttaat ttgcagcatg    240

 catcaggcag gtgctcttac agcctgttcc aagtgtggct taatccgtct ccaccaccag    300

 atctttctcc gtggattcct ctgctaagac cgctgcc atg cca gtg acg gta acc     355
                                          Met Pro Val Thr Val Thr
                                            1               5

 cgc acc acc atc aca acc acc acg acg tca tct tcg ggc ctg ggg tcc      403
 Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser Ser Ser Gly Leu Gly Ser
              10                  15                  20

 ccc atg atc gtg ggg tcc cct cgg gcc ctg aca cag ccc ctg ggt ctc      451
 Pro Met Ile Val Gly Ser Pro Arg Ala Leu Thr Gln Pro Leu Gly Leu
          25                  30                  35

 ctt cgc ctg ctg cag ctg gtg tct acc tgc gtg gcc ttc tcg ctg gtg      499
 Leu Arg Leu Leu Gln Leu Val Ser Thr Cys Val Ala Phe Ser Leu Val
      40                  45                  50

 gct agc gtg ggc gcc tgg acg ggg tcc atg ggc aac tgg tcc atg ttc      547
 Ala Ser Val Gly Ala Trp Thr Gly Ser Met Gly Asn Trp Ser Met Phe
  55                  60                  65                  70

 acc tgg tgc ttc tgc ttc tcc gtg acc ctg atc atc ctc atc gtg gag      595
 Thr Trp Cys Phe Cys Phe Ser Val Thr Leu Ile Ile Leu Ile Val Glu
                  75                  80                  85

 ctg tgc ggg ctc cag gcc cgc ttc ccc ctg tct tgg cgc aac ttc ccc      643
 Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu Ser Trp Arg Asn Phe Pro
              90                  95                 100

 atc acc ttc gcc tgc tat gcg gcc ctc ttc tgc ctc tcg gcc tcc atc      691
 Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe Cys Leu Ser Ala Ser Ile
         105                 110                 115

 atc tac ccc acc acc tat gtc cag ttc ctg tcc cac ggc cgt tcg cgg      739
 Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu Ser His Gly Arg Ser Arg
     120                 125                 130

 gac cac gcc atc gcc gcc acc ttc ttc tcc tgc atc gcg tgt gtg gct      787
 Asp His Ala Ile Ala Ala Thr Phe Phe Ser Cys Ile Ala Cys Val Ala
 135                 140                 145                 150

 tac gcc acc gaa gtg gcc tgg acc cgg gcc cgg ccc ggc gag atc act      835
 Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala Arg Pro Gly Glu Ile Thr
                 155                 160                 165

 ggc tat atg gcc acc gta ccc ggg ctg ctg aag gtg ctg gag acc ttc      883
 Gly Tyr Met Ala Thr Val Pro Gly Leu Leu Lys Val Leu Glu Thr Phe
             170                 175                 180

 gtt gcc tgc atc atc ttc gcg ttc atc agc gac ccc aac ctg tac cag      931
 Val Ala Cys Ile Ile Phe Ala Phe Ile Ser Asp Pro Asn Leu Tyr Gln
         185                 190                 195

 cac cag ccg gcc ctg gag tgg tgc gtg gcg gtg tac gcc atc tgc ttc      979
 His Gln Pro Ala Leu Glu Trp Cys Val Ala Val Tyr Ala Ile Cys Phe
     200                 205                 210

 atc cta gcg gcc atc gcc atc ctg ctg aac ctg ggg gag tgc acc aac     1027
 Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn Leu Gly Glu Cys Thr Asn
 215                 220                 225                 230

 gtg cta ccc atc ccc ttc ccc agc ttc ctg tcg ggg ctg gcc ttg ctg     1075
 Val Leu Pro Ile Pro Phe Pro Ser Phe Leu Ser Gly Leu Ala Leu Leu
                 235                 240                 245

 tct gtc ctc ctc tat gcc acc gcc ctt gtt ctc tgg ccc ctc tac cag     1123
 Ser Val Leu Leu Tyr Ala Thr Ala Leu Val Leu Trp Pro Leu Tyr Gln
             250                 255                 260

 ttc gat gag aag tat ggc ggc cag cct cgg cgc tcg aga gat gta agc     1171
 Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg Arg Ser Arg Asp Val Ser
         265                 270                 275

 tgc agc cgc agc cat gcc tac tac gtg tgt gcc tgg gac cgc cga ctg     1219
 Cys Ser Arg Ser His Ala Tyr Tyr Val Cys Ala Trp Asp Arg Arg Leu
     280                 285                 290

 gct gtg gcc atc ctg acg gcc atc aac cta ctg gcg tat gtg gct gac     1267
 Ala Val Ala Ile Leu Thr Ala Ile Asn Leu Leu Ala Tyr Val Ala Asp
 295                 300                 305                 310

 ctg gtg cac tct gcc cac ctg gtt ttt gtc aag gtc taag actctcccaa     1317
 Leu Val His Ser Ala His Leu Val Phe Val Lys Val 
                 315                 320

 gaggctcccg ttccctctcc aacctctttg ttcttcttgc ccgagttttc tttatggagt   1377

 acttctttcc tccgcctttc ctctgttttc ctcttcctgt ctcccctccc tcccaccttt   1437

 ttctttcctt cccaattcct tgcactctaa ccagttcttg gatgcatctt cttccttccc   1497

 tttcctcttg ctgtttcctt cctgtgttgt tttgttgccc acatcctgtt ttcacccctg   1557

 agccaccgcg cctggccaag gttgtcttta ttcagtgccg gtaggcagga gtccacacta   1617

 taaagtccaa ggtcattcct ggcagtaaaa ggttttttcc tgacagtttg tatggggaag   1677

 ccaggaggta actgtttggc atgttcttgt ttggaaacag cgggctctcc cattgataga   1737

 acactaaagt atcccagg                                                 1755




      <210> 111
      <211> 2487
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (62)..(2101)

      <400> 111
 acggatcctt aattaaatta atcccccccc ccccagagag cagccgggct gccagcgttt     60

 c    atg atc aac atg gga gac tcc cac gtg gac acc agc tcc acc gtg     106
      Met Ile Asn Met Gly Asp Ser His Val Asp Thr Ser Ser Thr Val
        1               5                  10                  15

 tcc gag gcg gtg gcc gaa gaa gta tct ctt ttc agc atg acg gac atg      154
 Ser Glu Ala Val Ala Glu Glu Val Ser Leu Phe Ser Met Thr Asp Met
                  20                  25                  30

 att ctg ttt tcg ctc atc gtg ggt ctc cta acc tac tgg ttc ctc ttc      202
 Ile Leu Phe Ser Leu Ile Val Gly Leu Leu Thr Tyr Trp Phe Leu Phe
              35                  40                  45

 aga aag aaa aaa gaa gaa gtc ccc gag ttc acc aaa att cag aca ttg      250
 Arg Lys Lys Lys Glu Glu Val Pro Glu Phe Thr Lys Ile Gln Thr Leu
          50                  55                  60

 acc tcc tct gtc aga gag agc agc ttt gtg gaa aag atg aag aaa acg      298
 Thr Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys Met Lys Lys Thr
      65                  70                  75

 ggg agg aac atc atc gtg ttc tac ggc tcc cag acg ggg act gca gag      346
 Gly Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu
  80                  85                  90                  95

 gag ttt gcc aac cgc ctg tcc aag gac gcc cac cgc tac ggg atg cga      394
 Glu Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg Tyr Gly Met Arg
                 100                 105                 110

 ggc atg tca gcg gac cct gag gag tat gac ctg gcc gac ctg agc agc      442
 Gly Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala Asp Leu Ser Ser
             115                 120                 125

 ctg cca gag atc gac aac gcc ctg gtg gtt ttc tgc atg gcc acc tac      490
 Leu Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys Met Ala Thr Tyr
         130                 135                 140

 ggt gag gga gac ccc acc gac aat gcc cag gac ttc tac gac tgg ctg      538
 Gly Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe Tyr Asp Trp Leu
     145                 150                 155

 cag gag aca gac gtg gat ctc tct ggg gtc aag ttc gcg gtg ttt ggt      586
 Gln Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe Ala Val Phe Gly
 160                 165                 170                 175

 ctt ggg aac aag acc tac gag cac ttc aat gcc atg ggc aag tac gtg      634
 Leu Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met Gly Lys Tyr Val
                 180                 185                 190

 gac aag cgg ctg gag cag ctc ggc gcc cag cgc atc ttt gag ctg ggg      682
 Asp Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile Phe Glu Leu Gly
             195                 200                 205

 ttg ggc gac gac gat ggg aac ttg gag gag gac ttc atc acc tgg cga      730
 Leu Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe Ile Thr Trp Arg
         210                 215                 220

 gag cag ttc tgg ccg gcc gtg tgt gaa cac ttt ggg gtg gaa gcc act      778
 Glu Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly Val Glu Ala Thr
     225                 230                 235

 ggc gag gag tcc agc att cgc cag tac gag ctt gtg gtc cac acc gac      826
 Gly Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val Val His Thr Asp
 240                 245                 250                 255

 ata gat gcg gcc aag gtg tac atg ggg gag atg ggc cgg ctg aag agc      874
 Ile Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly Arg Leu Lys Ser
                 260                 265                 270

 tac gag aac cag aag ccc ccc ttt gat gcc aag aat ccg ttc ctg gct      922
 Tyr Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn Pro Phe Leu Ala
             275                 280                 285

 gca gtc acc acc aac cgg aag ctg aac cag gga acc gag cgc cac ctc      970
 Ala Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr Glu Arg His Leu
         290                 295                 300

 atg cac ctg gaa ttg gac atc tcg gac tcc aaa atc agg tat gaa tct     1018
 Met His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile Arg Tyr Glu Ser
     305                 310                 315

 ggg gac cac gtg gct gtg tac cca gcc aac gac tct gct ctc gtc aac     1066
 Gly Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser Ala Leu Val Asn
 320                 325                 330                 335

 cag ctg ggc aaa atc ctg ggt gcc gac ctg gac gtc gtc atg tcc ctg     1114
 Gln Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val Val Met Ser Leu
                 340                 345                 350

 aac aac ctg gat gag gag tcc aac aag aag cac cca ttc ccg tgc cct     1162
 Asn Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro Phe Pro Cys Pro
             355                 360                 365

 acg tcc tac cgc acg gcc ctc acc tac tac ctg gac atc acc aac ccg     1210
 Thr Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp Ile Thr Asn Pro
         370                 375                 380

 ccg cgt acc aac gtg ctg tac gag ctg gcg cag tac gcc tcg gag ccc     1258
 Pro Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr Ala Ser Glu Pro
     385                 390                 395

 tcg gag cag gag ctg ctg cgc aag atg gcc tcc tcc tcc ggc gag ggc     1306
 Ser Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser Ser Gly Glu Gly
 400                 405                 410                 415

 aag gag ctg tac ctg agc tgg gtg gtg gag gcc cgg agg cac atc ctg     1354
 Lys Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg Arg His Ile Leu
                 420                 425                 430

 gcc atc ctg cag gac tgc ccg tcc ctg cgg ccc ccc atc gac cac ctg     1402
 Ala Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro Ile Asp His Leu
             435                 440                 445

 tgt gag ctg ctg ccg cgc ctg cag gcc cgc tac tac tcc atc gcc tca     1450
 Cys Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr Ser Ile Ala Ser
         450                 455                 460

 tcc tcc aag gtc cac ccc aac tct gtg cac atc tgt gcg gtg gtt gtg     1498
 Ser Ser Lys Val His Pro Asn Ser Val His Ile Cys Ala Val Val Val
     465                 470                 475

 gag tac gag acc aag gcc ggc cgc atc aac aag ggc gtg gcc acc aac     1546
 Glu Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly Val Ala Thr Asn
 480                 485                 490                 495

 tgg ctg cgg gcc aag gag cct gtc ggg gag aac ggc ggc cgt gcg ctg     1594
 Trp Leu Arg Ala Lys Glu Pro Val Gly Glu Asn Gly Gly Arg Ala Leu
                 500                 505                 510

 gtg ccc atg ttc gtg cgc aag tcc cag ttc cgc ctg ccc ttc aag gcc     1642
 Val Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu Pro Phe Lys Ala
             515                 520                 525

 acc acg cct gtc atc atg gtg ggc ccc ggc acc ggg gtg gca ccc ttc     1690
 Thr Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe
         530                 535                 540

 ata ggc ttc atc cag gag cgg gcc tgg ctg cga cag cag ggc aag gag     1738
 Ile Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln Gln Gly Lys Glu
     545                 550                 555

 gtg ggg gag acg ctg ctg tac tac ggc tgc cgc cgc tcg gat gag gac     1786
 Val Gly Glu Thr Leu Leu Tyr Tyr Gly Cys Arg Arg Ser Asp Glu Asp
 560                 565                 570                 575

 tac ctg tac cgg gag gag ctg gcg cag ttc cac agg gac ggt gcg ctc     1834
 Tyr Leu Tyr Arg Glu Glu Leu Ala Gln Phe His Arg Asp Gly Ala Leu
                 580                 585                 590

 acc cag ctc aac gtg gcc ttc tcc cgg gag cag tcc cac aag gtc tac     1882
 Thr Gln Leu Asn Val Ala Phe Ser Arg Glu Gln Ser His Lys Val Tyr
             595                 600                 605

 gtc cag cac ctg cta aag caa gac cga gag cac ctg tgg aag ttg atc     1930
 Val Gln His Leu Leu Lys Gln Asp Arg Glu His Leu Trp Lys Leu Ile
         610                 615                 620

 gaa ggc ggt gcc cac atc tac gtc tgt ggg gat gca cgg aac atg gcc     1978
 Glu Gly Gly Ala His Ile Tyr Val Cys Gly Asp Ala Arg Asn Met Ala
     625                 630                 635

 agg gat gtg cag aac acc ttc tac gac atc gtg gct gag ctc ggg gcc     2026
 Arg Asp Val Gln Asn Thr Phe Tyr Asp Ile Val Ala Glu Leu Gly Ala
 640                 645                 650                 655

 atg gag cac gcg cag gcg gtg gac tac atc aag aaa ctg atg acc aag     2074
 Met Glu His Ala Gln Ala Val Asp Tyr Ile Lys Lys Leu Met Thr Lys
                 660                 665                 670

 ggc cgc tac tcc ctg gac gtg tgg agc taggg gcctgcctgc cccacccacc     2126
 Gly Arg Tyr Ser Leu Asp Val Trp Ser 
             675                 680

 ccacagactc cggcctgtaa tcagctctcc tggctccctc ccgtagtctc ctgggtgtgt   2186

 ttggcttggc cttggcatgg gcgcaggccc agtgacaaag actcctctgg gcctggggtg   2246

 catcctcctc agcccccagg ccaggtgagg tccaccggcc cctggcagca cagcccaggg   2306

 cctgcatggg ggcaccgggc tccatgcctc tggaggcctc tggccctcgg tggctgcaca   2366

 gaagggctct ttctctctgc tgagctgggc ccagcccctc cacgtgattt ccagtgagtg   2426

 taaataattt taaataacct ctggcccttg gaataaagtt ctgttttctg taaaaaaaaa   2486

 a                                                                   2487




      <210> 112
      <211> 2107
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1767)

      <400> 112
  atg tcg cgg agg ctg ctg ccc cgg gcg gag aag cgg cgt cgg cgg ctg      48
  Met Ser Arg Arg Leu Leu Pro Arg Ala Glu Lys Arg Arg Arg Arg Leu
    1               5                  10                  15

 gag cag agg cag cag ccg gac gag cag cgg agg cgg tcg gga gcg atg       96
 Glu Gln Arg Gln Gln Pro Asp Glu Gln Arg Arg Arg Ser Gly Ala Met
              20                  25                  30

 gtg aag atg gcg gcg gcg ggc ggc gga ggc ggc ggt ggc cgc tac tac      144
 Val Lys Met Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Arg Tyr Tyr
          35                  40                  45

 ggc ggc ggc agt gag ggc ggc cgg gcc cct aag cgg ctc aag act gac      192
 Gly Gly Gly Ser Glu Gly Gly Arg Ala Pro Lys Arg Leu Lys Thr Asp
      50                  55                  60

 aac gcc ggc gac cag cac gga ggc ggc ggc ggt ggc ggt gga gga gcc      240
 Asn Ala Gly Asp Gln His Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala
  65                  70                  75                  80

 ggg gcg gcg ggc ggc ggc ggc ggt ggg gag aac tac gat gac ccg cac      288
 Gly Ala Ala Gly Gly Gly Gly Gly Gly Glu Asn Tyr Asp Asp Pro His
                  85                  90                  95

 aaa acc cct gcc tcc cca gtt gtc cac atc agg ggc ctg att gac ggt      336
 Lys Thr Pro Ala Ser Pro Val Val His Ile Arg Gly Leu Ile Asp Gly
             100                 105                 110

 gtg gtg gaa gca gac ctt gtg gag gcc ttg cag gag ttt gga ccc atc      384
 Val Val Glu Ala Asp Leu Val Glu Ala Leu Gln Glu Phe Gly Pro Ile
         115                 120                 125

 agc tat gtg gtg gta atg cct aaa aag aga caa gca ctg gtg gag ttt      432
 Ser Tyr Val Val Val Met Pro Lys Lys Arg Gln Ala Leu Val Glu Phe
     130                 135                 140

 gaa gat gtg ttg ggg gct tgc aac gca gtg aac tac gca gcc gac aac      480
 Glu Asp Val Leu Gly Ala Cys Asn Ala Val Asn Tyr Ala Ala Asp Asn
 145                 150                 155                 160

 caa ata tac att gct ggt cac cca gct ttt gtc aac tac tct acc agc      528
 Gln Ile Tyr Ile Ala Gly His Pro Ala Phe Val Asn Tyr Ser Thr Ser
                 165                 170                 175

 cag aag atc tcc cgc cct ggg gac tcg gat gac tcc cgg agc gtg aac      576
 Gln Lys Ile Ser Arg Pro Gly Asp Ser Asp Asp Ser Arg Ser Val Asn
             180                 185                 190

 agt gtg ctt ctc ttt acc atc ctg aac ccc att tat tcg atc acc acg      624
 Ser Val Leu Leu Phe Thr Ile Leu Asn Pro Ile Tyr Ser Ile Thr Thr
         195                 200                 205

 gat gtt ctt tac act atc tgt aat cct tgt ggc cct gtc cag aga att      672
 Asp Val Leu Tyr Thr Ile Cys Asn Pro Cys Gly Pro Val Gln Arg Ile
     210                 215                 220

 gtc att ttc agg aag aat gga gtt cag gcg atg gtg gaa ttt gac tca      720
 Val Ile Phe Arg Lys Asn Gly Val Gln Ala Met Val Glu Phe Asp Ser
 225                 230                 235                 240

 gtt caa agt gcc cag cgg gcc aag gcc tct ctc aat ggg gct gat atc      768
 Val Gln Ser Ala Gln Arg Ala Lys Ala Ser Leu Asn Gly Ala Asp Ile
                 245                 250                 255

 tat tct ggc tgt tgc act ctg aag atc gaa tac gca aag cct aca cgc      816
 Tyr Ser Gly Cys Cys Thr Leu Lys Ile Glu Tyr Ala Lys Pro Thr Arg
             260                 265                 270

 ttg aat gtg ttc aag aat gat cag gat act tgg gac tac aca aac ccc      864
 Leu Asn Val Phe Lys Asn Asp Gln Asp Thr Trp Asp Tyr Thr Asn Pro
         275                 280                 285

 aat ctc agt gga caa ggt gac cct ggc agc aac ccc aac aaa cgc cag      912
 Asn Leu Ser Gly Gln Gly Asp Pro Gly Ser Asn Pro Asn Lys Arg Gln
     290                 295                 300

 agg cag ccc cct ctc ctg gga gat cac ccc gca gaa tat gga ggg ccc      960
 Arg Gln Pro Pro Leu Leu Gly Asp His Pro Ala Glu Tyr Gly Gly Pro
 305                 310                 315                 320

 cac ggt ggg tac cac agc cat tac cat gat gag ggc tac ggg ccc ccc     1008
 His Gly Gly Tyr His Ser His Tyr His Asp Glu Gly Tyr Gly Pro Pro
                 325                 330                 335

 cca cct cac tac gaa ggg aga agg atg ggt cca cca gtg ggg ggt cac     1056
 Pro Pro His Tyr Glu Gly Arg Arg Met Gly Pro Pro Val Gly Gly His
             340                 345                 350

 cgt cgg ggc cca agt cgc tac ggc ccc cag tat ggg cac ccc cca ccc     1104
 Arg Arg Gly Pro Ser Arg Tyr Gly Pro Gln Tyr Gly His Pro Pro Pro
         355                 360                 365

 cct ccc cca cca ccc gag tat ggc cct cac gcc gac agc cct gtg ctc     1152
 Pro Pro Pro Pro Pro Glu Tyr Gly Pro His Ala Asp Ser Pro Val Leu
     370                 375                 380

 atg gtc tat ggc ttg gat caa tct aag atg aac tgt gac cga gtc ttc     1200
 Met Val Tyr Gly Leu Asp Gln Ser Lys Met Asn Cys Asp Arg Val Phe
 385                 390                 395                 400

 aat gtc ttc tgc tta tat ggc aat gtg gag aag gtg aaa ttc atg aaa     1248
 Asn Val Phe Cys Leu Tyr Gly Asn Val Glu Lys Val Lys Phe Met Lys
                 405                 410                 415

 agc aag ccg ggg gcc gcc atg gtg gag atg gct gat ggc tac gct gta     1296
 Ser Lys Pro Gly Ala Ala Met Val Glu Met Ala Asp Gly Tyr Ala Val
             420                 425                 430

 gac cgg gcc att acc cac ctc aac aac aac ttc atg ttt ggg cag aag     1344
 Asp Arg Ala Ile Thr His Leu Asn Asn Asn Phe Met Phe Gly Gln Lys
         435                 440                 445

 ctg aat gtc tgt gtc tcc aag cag cca gcc atc atg cct ggt cag tca     1392
 Leu Asn Val Cys Val Ser Lys Gln Pro Ala Ile Met Pro Gly Gln Ser
     450                 455                 460

 tac ggg ttg gaa gac ggg tct tgc agt tac aaa gac ttc agt gaa tcc     1440
 Tyr Gly Leu Glu Asp Gly Ser Cys Ser Tyr Lys Asp Phe Ser Glu Ser
 465                 470                 475                 480

 cgg aac aat cgg ttc tcc acc cca gag cag gca gcc aag aac cgc atc     1488
 Arg Asn Asn Arg Phe Ser Thr Pro Glu Gln Ala Ala Lys Asn Arg Ile
                 485                 490                 495

 cag cac ccc agc aac gtg ctg cac ttc ttc aac gcc ccg ctg gag gtg     1536
 Gln His Pro Ser Asn Val Leu His Phe Phe Asn Ala Pro Leu Glu Val
             500                 505                 510

 acc gag gag aac ttc ttt gag atc tgc gat gag ctg gga gtg aag cgg     1584
 Thr Glu Glu Asn Phe Phe Glu Ile Cys Asp Glu Leu Gly Val Lys Arg
         515                 520                 525

 cca tct tct gtg aaa gta ttc tca ggc aaa agt gag cgc agc tcc tct     1632
 Pro Ser Ser Val Lys Val Phe Ser Gly Lys Ser Glu Arg Ser Ser Ser
     530                 535                 540

 gga ctg ctg gag tgg gaa tcc aag agc gat gcc ctg gag act ctg ggc     1680
 Gly Leu Leu Glu Trp Glu Ser Lys Ser Asp Ala Leu Glu Thr Leu Gly
 545                 550                 555                 560

 ttc ctg aac cat tac cag atg aaa aac cca aat ggt cca tac cct tac     1728
 Phe Leu Asn His Tyr Gln Met Lys Asn Pro Asn Gly Pro Tyr Pro Tyr
                 565                 570                 575

 act ctg aag ttg tgt ttc tcc act gct cag cac gcc tcc taattaggtg      1777
 Thr Leu Lys Leu Cys Phe Ser Thr Ala Gln His Ala Ser 
             580                 585

 cctaggaaga gtcccatctg agcaggaaga catttctctt ttctttatgc cattttttgt   1837

 ttttgttatt tgcaaaagat cttgtattcc tttttttttt tttttttttt aaatgctagg   1897

 tttgtagagg cttacttaac cttaatggaa acgctggaaa tctgcagggg gagggagagg   1957

 ggaactgtta tctcccaaga ttaaccttca cttttaaaaa attattgtac atgtgatttt   2017

 tttttttcct gttcatacat ttgtgctgcc catgtactct tggcacattt caataaaatt   2077

 gtttggaaaa taaacacagc aaaaaaaaaa                                    2107




      <210> 113
      <211> 2305
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (527)..(2302)

      <400> 113
 cactcgtccg gcgagaggca gtgacactga tcgggcgcag ggggccgagt cggagaccgt     60

 gccggagttc gggagcggca acagagtggg catagacact ccgagcagcc tcgccgtcgt    120

 ctctgcgttc ctgttgactg cctggctgcc ccctccccta ctcctcggtt cctggtgaag    180

 aggctgcgcg ctgctgtttg gggagggggt gtgtggagcc gggtcctgtg tccgcagtgg    240

 ctgctgtcgg ggggtcgcct gttcgcggag gtgcggagag actccttggg ggtcgagcac    300

 ataacggggt tcgggtgtct cgtgtgtgaa catcacaggt ctattctgga taagcaggtt    360

 ttgtgaagac atttattctt tcttggacct cagatttacc agacatctca tgggtttgtg    420

 gatgcactta gatgtttgca atgagcactg tggctggcat gccccagtgt tttggatacc    480

 aatgcatagg actccatagt aatcgaattt accagaggcg aacgtc   atg agc ata     535
                                                      Met Ser Ile
                                                        1

 gtg atc cca ttg ggg gtt gat aca gca gag acg tca tac ttg gaa atg      583
 Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr Leu Glu Met
       5                  10                  15

 gct gca ggt tca gaa cca gaa tcc gta gaa gct agc cct gtg gta gtt      631
 Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro Val Val Val
  20                  25                  30                  35

 gag aaa tcc aac agt tat ccc cac cag tta tat acc agc agc tca cat      679
 Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser Ser Ser His
                  40                  45                  50

 cat tca cac agt tac att ggt ttg ccc tat gcg gac cat aat tat ggt      727
 His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His Asn Tyr Gly
              55                  60                  65

 gct cgt cct cct ccg aca cct ccg gct tcc cct cct cca tca gtc ctt      775
 Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro Ser Val Leu
          70                  75                  80

 att agc aaa aat gaa gta ggc ata ttt acc act cct aat ttt gat gaa      823
 Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn Phe Asp Glu
      85                  90                  95

 act tcc agt gct act aca atc agc aca tct gag gat gga agt tat ggt      871
 Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly Ser Tyr Gly
 100                 105                 110                 115

 act gat gta acc agg tgc ata tgt ggt ttt aca cat gat gat gga tac      919
 Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp Asp Gly Tyr
                 120                 125                 130

 atg atc tgt tgt gac aaa tgc agc gtt tgg caa cat att gac tgc atg      967
 Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile Asp Cys Met
             135                 140                 145

 ggg att gat agg cag cat att cct gat aca tat cta tgt gaa cgt tgt     1015
 Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys Glu Arg Cys
         150                 155                 160

 cag cct agg aat ttg gat aaa gag agg gca gtg cta cta caa cgc cgg     1063
 Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu Gln Arg Arg
     165                 170                 175

 aaa agg gaa aat atg tca gat ggt gat acc agt gca act gag agt ggt     1111
 Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr Glu Ser Gly
 180                 185                 190                 195

 gat gag gtt cct gtg gaa tta tat act gca ttt cag cat act cca aca     1159
 Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His Thr Pro Thr
                 200                 205                 210

 tca att act tta act gct tca aga gtt tcc aaa gtt aat gat aaa aaa     1207
 Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn Asp Lys Lys
             215                 220                 225

 aaa aaa aaa agc ggg gag aaa gaa caa cac att tca aaa tgt aaa aag     1255
 Lys Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys Cys Lys Lys
         230                 235                 240

 ggt tca gct cca gag att gat cct tca tct gat ggt tca aat ttt gga     1303
 Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly
     245                 250                 255

 tgg gag aca aag atc aaa gca tgg atg gat cga tat gaa gaa gca aat     1351
 Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn
 260                 265                 270                 275

 aac aac cag tac agt gag ggt gtt cag agg gag gca caa aga ata gct     1399
 Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala
                 280                 285                 290

 ctg aga tta ggc aat gga aat gac aaa aaa gag atg aat aaa tcc gat     1447
 Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp
             295                 300                 305

 ttg aat acc aac aat ttg ctc ttc aaa cct cct gta gag agc cat ata     1495
 Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile
         310                 315                 320

 caa aag aat aag aaa att ctt aaa tct gca aaa gat ttg cct cct gat     1543
 Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp
     325                 330                 335

 gca ctt atc att gaa tac aga ggg aag ttt atg ctg aga gaa cag ttt     1591
 Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe
 340                 345                 350                 355

 gaa gca aat ggg tat ttc ttt aaa aga cca tac cct ttt gtg tta ttc     1639
 Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe
                 360                 365                 370

 tac tct aaa ttt cat ggg cta gaa atg tgt gtt gat gca agg act ttt     1687
 Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe
             375                 380                 385

 ggg aat gag gct cga ttc atc agg cgg tct tgt aca ccc aat gca gag     1735
 Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu
         390                 395                 400

 gtg agg cat gaa att caa gat gga acc ata cat ctt tat att tat tct     1783
 Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser
     405                 410                 415

 ata cac agt att cca aag gga act gaa att act att gcc ttt gat ttt     1831
 Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe
 420                 425                 430                 435

 gac tat gga aat tgt aag tac aag gtg gac tgt gca tgc ctc aaa gaa     1879
 Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu
                 440                 445                 450

 aac cca gag tgc cct gtt cta aaa cgt agt tct gaa tcc atg gaa aat     1927
 Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn
             455                 460                 465

 atc aat agt ggt tat gag acc aga cgg aaa aaa gga aaa aaa gac aaa     1975
 Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys
         470                 475                 480

 gat att tca aaa gaa aaa gat aca caa aat cag aat att act ttg gat     2023
 Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp
     485                 490                 495

 tgt gaa gga acg acc aac aaa atg aag agc cca gaa act aaa caa aga     2071
 Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg
 500                 505                 510                 515

 aag ctt tct cca ctg aga cta tca gta tca aat aat cag gaa cca gat     2119
 Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp
                 520                 525                 530

 ttt att gat gat ata gaa gaa aaa act cct att agt aat gaa gta gaa     2167
 Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu
             535                 540                 545

 atg gaa tca gag gag cag att gca gaa agg aaa agg aag atg aac tgg     2215
 Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Asn Trp
         550                 555                 560

 aca gtt gat gga tgt ggt tcc tgg ttc tgg ttt aga gct gaa gca tct     2263
 Thr Val Asp Gly Cys Gly Ser Trp Phe Trp Phe Arg Ala Glu Ala Ser
     565                 570                 575

 gtc aag gct ctg ggt ctt act ctt aat gtt ctc ttt gga tag             2305
 Val Lys Ala Leu Gly Leu Thr Leu Asn Val Leu Phe Gly 
 580                 585                 590





      <210> 114
      <211> 2344
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (527)..(2341)

      <400> 114
 cactcgtccg gcgagaggca gtgacactga tcgggcgcag ggggccgagt cggagaccgt     60

 gccggagttc gggagcggca acagagtggg catagacact ccgagcagcc tcgccgtcgt    120

 ctctgcgttc ctgttgactg cctggctgcc ccctccccta ctcctcggtt cctggtgaag    180

 aggctgcgcg ctgctgtttg gggagggggt gtgtggagcc gggtcctgtg tccgcagtgg    240

 ctgctgtcgg ggggtcgcct gttcgcggag gtgcggagag actccttggg ggtcgagcac    300

 ataacggggt tcgggtgtct cgtgtgtgaa catcacaggt ctattctgga taagcaggtt    360

 ttgtgaagac atttattctt tcttggacct cagatttacc agacatctca tgggtttgtg    420

 gatgcactta gatgtttgca atgagcactg tggctggcat gccccagtgt tttggatacc    480

 aatgcatagg actccatagt aatcgaattt accagaggcg aacgtc   atg agc ata     535
                                                      Met Ser Ile
                                                        1

 gtg atc cca ttg ggg gtt gat aca gca gag acg tca tac ttg gaa atg      583
 Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr Leu Glu Met
       5                  10                  15

 gct gca ggt tca gaa cca gaa tcc gta gaa gct agc cct gtg gta gtt      631
 Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro Val Val Val
  20                  25                  30                  35

 gag aaa tcc aac agt tat ccc cac cag tta tat acc agc agc tca cat      679
 Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser Ser Ser His
                  40                  45                  50

 cat tca cac agt tac att ggt ttg ccc tat gcg gac cat aat tat ggt      727
 His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His Asn Tyr Gly
              55                  60                  65

 gct cgt cct cct ccg aca cct ccg gct tcc cct cct cca tca gtc ctt      775
 Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro Ser Val Leu
          70                  75                  80

 att agc aaa aat gaa gta ggc ata ttt acc act cct aat ttt gat gaa      823
 Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn Phe Asp Glu
      85                  90                  95

 act tcc agt gct act aca atc agc aca tct gag gat gga agt tat ggt      871
 Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly Ser Tyr Gly
 100                 105                 110                 115

 act gat gta acc agg tgc ata tgt ggt ttt aca cat gat gat gga tac      919
 Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp Asp Gly Tyr
                 120                 125                 130

 atg atc tgt tgt gac aaa tgc agc gtt tgg caa cat att gac tgc atg      967
 Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile Asp Cys Met
             135                 140                 145

 ggg att gat agg cag cat att cct gat aca tat cta tgt gaa cgt tgt     1015
 Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys Glu Arg Cys
         150                 155                 160

 cag cct agg aat ttg gat aaa gag agg gca gtg cta cta caa cgc cgg     1063
 Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu Gln Arg Arg
     165                 170                 175

 aaa agg gaa aat atg tca gat ggt gat acc agt gca act gag agt ggt     1111
 Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr Glu Ser Gly
 180                 185                 190                 195

 gat gag gtt cct gtg gaa tta tat act gca ttt cag cat act cca aca     1159
 Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His Thr Pro Thr
                 200                 205                 210

 tca att act tta act gct tca aga gtt tcc aaa gtt aat gat aaa aaa     1207
 Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn Asp Lys Lys
             215                 220                 225

 aaa aaa aaa agc ggg gag aaa gaa caa cac att tca aaa tgt aaa aag     1255
 Lys Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys Cys Lys Lys
         230                 235                 240

 gca ttt cgt gaa gga tct agg aag tca tca aga gtt aag ggt tca gct     1303
 Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys Gly Ser Ala
     245                 250                 255

 cca gag att gat cct tca tct gat ggt tca aat ttt gga tgg gag aca     1351
 Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly Trp Glu Thr
 260                 265                 270                 275

 aag atc aaa gca tgg atg gat cga tat gaa gaa gca aat aac aac cag     1399
 Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn Asn Asn Gln
                 280                 285                 290

 tac agt gag ggt gtt cag agg gag gca caa aga ata gct ctg aga tta     1447
 Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala Leu Arg Leu
             295                 300                 305

 ggc aat gga aat gac aaa aaa gag atg aat aaa tcc gat ttg aat acc     1495
 Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp Leu Asn Thr
         310                 315                 320

 aac aat ttg ctc ttc aaa cct cct gta gag agc cat ata caa aag aat     1543
 Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile Gln Lys Asn
     325                 330                 335

 aag aaa att ctt aaa tct gca aaa gat ttg cct cct gat gca ctt atc     1591
 Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp Ala Leu Ile
 340                 345                 350                 355

 att gaa tac aga ggg aag ttt atg ctg aga gaa cag ttt gaa gca aat     1639
 Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe Glu Ala Asn
                 360                 365                 370

 ggg tat ttc ttt aaa aga cca tac cct ttt gtg tta ttc tac tct aaa     1687
 Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe Tyr Ser Lys
             375                 380                 385

 ttt cat ggg cta gaa atg tgt gtt gat gca agg act ttt ggg aat gag     1735
 Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe Gly Asn Glu
         390                 395                 400

 gct cga ttc atc agg cgg tct tgt aca ccc aat gca gag gtg agg cat     1783
 Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu Val Arg His
     405                 410                 415

 gaa att caa gat gga acc ata cat ctt tat att tat tct ata cac agt     1831
 Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser Ile His Ser
 420                 425                 430                 435

 att cca aag gga act gaa att act att gcc ttt gat ttt gac tat gga     1879
 Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe Asp Tyr Gly
                 440                 445                 450

 aat tgt aag tac aag gtg gac tgt gca tgc ctc aaa gaa aac cca gag     1927
 Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu Asn Pro Glu
             455                 460                 465

 tgc cct gtt cta aaa cgt agt tct gaa tcc atg gaa aat atc aat agt     1975
 Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn Ile Asn Ser
         470                 475                 480

 ggt tat gag acc aga cgg aaa aaa gga aaa aaa gac aaa gat att tca     2023
 Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys Asp Ile Ser
     485                 490                 495

 aaa gaa aaa gat aca caa aat cag aat att act ttg gat tgt gaa gga     2071
 Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp Cys Glu Gly
 500                 505                 510                 515

 acg acc aac aaa atg aag agc cca gaa act aaa caa aga aag ctt tct     2119
 Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg Lys Leu Ser
                 520                 525                 530

 cca ctg aga cta tca gta tca aat aat cag gaa cca gat ttt att gat     2167
 Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp Phe Ile Asp
             535                 540                 545

 gat ata gaa gaa aaa act cct att agt aat gaa gta gaa atg gaa tca     2215
 Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu Met Glu Ser
         550                 555                 560

 gag gag cag att gca gaa agg aaa agg aag atg aac tgg aca gtt gat     2263
 Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Asn Trp Thr Val Asp
     565                 570                 575

 gga tgt ggt tcc tgg ttc tgg ttt aga gct gaa gca tct gtc aag gct     2311
 Gly Cys Gly Ser Trp Phe Trp Phe Arg Ala Glu Ala Ser Val Lys Ala
 580                 585                 590                 595

 ctg ggt ctt act ctt aat gtt ctc ttt gga tag                         2344
 Leu Gly Leu Thr Leu Asn Val Leu Phe Gly 
                 600                 605





      <210> 115
      <211> 9483
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(9354)

      <400> 115
  atg cgg agt agg ctt ccc cca gcg ctt gcc gcc ctg ggc gcg gcc cta      48
  Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu
    1               5                  10                  15

 ctc ctg tct tcc att gag gca gaa gtt gac cca cct tca gac ttg aat       96
 Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn
              20                  25                  30

 ttt aaa att ata gat gaa aat act gtt cat atg tca tgg gca gaa cca      144
 Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Glu Pro
          35                  40                  45

 gtt gat cca att gtg ggt tac aga ata acg gtg gac cct aca acg gat      192
 Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp
      50                  55                  60

 ggg cct act aaa gaa ttt acc ctt tca gct agt acc act gaa act tta      240
 Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu
  65                  70                  75                  80

 ttg tca gaa ctt gta cct gaa aca gag tat gtg gtg aca ata act tca      288
 Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser
                  85                  90                  95

 tat gat gaa gta gaa gaa agt gta cca gtt ata gga caa cta aca att      336
 Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile
             100                 105                 110

 caa aca ggt agt tcg aca aag cca gtg gag aag aaa cct gga aaa acc      384
 Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr
         115                 120                 125

 gag ata caa aaa tgc tct gtc agt gcc tgg act gat ttg gtt ttc ctc      432
 Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu
     130                 135                 140

 gtg gat ggc tct tgg agt gtg gga aga aat aat ttc aag tac att tta      480
 Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu
 145                 150                 155                 160

 gac ttc att gct gct ctt gtg tct gct ttt gac att ggg gaa gag aag      528
 Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys
                 165                 170                 175

 aca aga gtt gga gtt gtt caa tac agc tct gac acc agg act gaa ttt      576
 Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe
             180                 185                 190

 aac tta aat cag tac tac caa agg gat gaa ctt ctt gct gca ata aaa      624
 Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys
         195                 200                 205

 aaa att cca tat aaa ggt ggc aac aca atg aca ggg gat gcc att gat      672
 Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp
     210                 215                 220

 tat tta gtt aaa aat act ttc acg gaa tct gct ggg gca aga gtt ggc      720
 Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly
 225                 230                 235                 240

 ttt cct aaa gtg gca att att att acg gat gga aaa tcc cag gat gaa      768
 Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu
                 245                 250                 255

 gtg gaa att cca gca aga gag ctt cgt aat gtt gga gtt gaa gtt ttc      816
 Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe
             260                 265                 270

 tcc ttg ggc att aaa gct gca gat gca aaa gaa ctc aaa caa att gcc      864
 Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala
         275                 280                 285

 tcc aca cct tca ctg aac cat gtt ttc aat gtg gcc aac ttt gat gca      912
 Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala
     290                 295                 300

 att gtg gat att cag aat gag atc atc tcc cag gtg tgc tca gga gtt      960
 Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val
 305                 310                 315                 320

 gat gag cag ctt ggt gaa ttg gtt agt gga gaa gaa gtt gtt gag cct     1008
 Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro
                 325                 330                 335

 cct tca aat ttg att gcc atg gaa gtc tct tca aaa tat gtt aag cta     1056
 Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu
             340                 345                 350

 aat tgg aat cca tct cct agt cca gtg act ggc tac aaa gtc atc ctc     1104
 Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu
         355                 360                 365

 aca cca atg act gca gga agc cga cag cac gct ctg agt gtg ggg cct     1152
 Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro
     370                 375                 380

 cag aca acc acg ctc agt gtt cgc gac ctc tca gca gac acg gag tac     1200
 Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr
 385                 390                 395                 400

 cag atc agt gtt tcc gcc atg aag gga atg aca tcc agt gaa ccc att     1248
 Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile
                 405                 410                 415

 tca ata atg gag aag act cag cca atg aaa gtt caa gtg gaa tgt tca     1296
 Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser
             420                 425                 430

 cgt ggt gtg gat ata aaa gcc gat att gtg ttt ttg gtt gat ggc tcc     1344
 Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser
         435                 440                 445

 tat agc att ggg att gca aac ttt gtt aaa gtt aga gcc ttt ttg gaa     1392
 Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu
     450                 455                 460

 gtt ctt gta aaa agt ttt gaa att tca cca aat agg gtc cag att agt     1440
 Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser
 465                 470                 475                 480

 ctt gtg caa tac agc cgg gat cct cat act gag ttc act ttg aaa aaa     1488
 Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys
                 485                 490                 495

 ttc acc aaa gtt gaa gat ata att gaa gca ata aac acc ttc cct tac     1536
 Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr
             500                 505                 510

 aga gga gga tct aca aat act ggc aaa gca atg act tat gtc aga gag     1584
 Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu
         515                 520                 525

 aaa ata ttt gtg cct agc aag gga tca aga agc aat gtg cca aag gtc     1632
 Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val
     530                 535                 540

 atg att ctt atc acg gat ggg aaa tca tca gat gct ttc aga gat cct     1680
 Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro
 545                 550                 555                 560

 gcg ata aaa ctg agg aat tca gat gtt gaa atc ttt gca gtt ggt gtg     1728
 Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val
                 565                 570                 575

 aag gat gcc gtt cgc tca gaa ttg gaa gct att gcc tct cct cct gca     1776
 Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala
             580                 585                 590

 gag acc cat gtg ttc aca gtg gaa gat ttt gat gct ttt cag agg ata     1824
 Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile
         595                 600                 605

 tct ttt gaa ctc aca cag tct atc tgt ctt aga att gag caa gaa ttg     1872
 Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu
     610                 615                 620

 gca gct ata aag aag aaa gct tac gtc cct cca aag gat ctt agt ttt     1920
 Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe
 625                 630                 635                 640

 tca gaa gtg act tct tat ggt ttc aaa acc aac tgg tct cca gct gga     1968
 Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly
                 645                 650                 655

 gaa aat gtt ttt tca tat cac atc acc tac aag gaa gcg gct ggg gat     2016
 Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp
             660                 665                 670

 gat gag gtc act gtg gtg gag cca gca tcg agc acc agt gtt gtt ctc     2064
 Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu
         675                 680                 685

 agc agc ctg aag cca gag acc ttg tat ttg gtc aat gtg act gcg gag     2112
 Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu
     690                 695                 700

 tat gag gat ggc ttc agc att ccc tta gct gga gag gag acc acc gaa     2160
 Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu
 705                 710                 715                 720

 gaa gta aaa gga gca cct cga aac cta aag gtg aca gat gag act aca     2208
 Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr
                 725                 730                 735

 gat agt ttc aaa att act tgg act caa gct cca ggg aga gtt tta aga     2256
 Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg
             740                 745                 750

 tgt cga att ata tat aga cca gtt gct ggt gga gag agc aga gaa gtt     2304
 Cys Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val
         755                 760                 765

 acc acc cca ccc aat cag agg agg aga aca ctg gag aac ttg att cca     2352
 Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro
     770                 775                 780

 gac acg aaa tat gaa gta tct gta att cct gaa tac ttc tca gga cct     2400
 Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro
 785                 790                 795                 800

 ggt act cca tta act gga aat gca gcc act gaa gaa gtt aga ggg aat     2448
 Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn
                 805                 810                 815

 cca aga gac tta aga gtt tct gac cct acg acg tct act atg aaa tta     2496
 Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu
             820                 825                 830

 tct tgg agt ggg gca cca gga aaa gtg aaa cag tat ctc gtc aca tat     2544
 Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr
         835                 840                 845

 acc cca gtg gca ggg ggt gaa act caa gag gtc act gtg agg gga gat     2592
 Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp
     850                 855                 860

 aca acc aat acg gtg ctg cag gga ttg aag gaa ggg aca caa tac gcc     2640
 Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala
 865                 870                 875                 880

 tta tct gtg aca gca ctg tat gcg tct ggg gct ggc gac gcc ctc ttt     2688
 Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe
                 885                 890                 895

 ggt gaa gga aca aca ctt gaa gaa cgt ggt tct cct caa gat tta gtt     2736
 Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val
             900                 905                 910

 act aaa gac atc act gac aca tca att ggg gct tat tgg aca tct gct     2784
 Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala
         915                 920                 925

 cca gga atg gtt cgc ggt tac agg gtc tca tgg aaa tca ctt tat gat     2832
 Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp
     930                 935                 940

 gat gtt gac act gga gag aaa aat ctg cct gaa gat gca att cat acg     2880
 Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr
 945                 950                 955                 960

 atg ata gaa aat ctg cag cca gag acc aaa tac aga att tca gta ttt     2928
 Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe
                 965                 970                 975

 gcc act tac agc agt gga gaa gga gaa cct ttg act gga gat gcc aca     2976
 Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr
             980                 985                 990

 act gaa tta tct caa gat tcc aaa acc ctg aaa gta gat gaa gaa aca     3024
 Thr Glu Leu Ser Gln Asp Ser Lys Thr Leu Lys Val Asp Glu Glu Thr
         995                1000                1005

 gaa aac aca atg aga gtt aca tgg aaa cca gca cca ggg aaa gtc gtc     3072
 Glu Asn Thr Met Arg Val Thr Trp Lys Pro Ala Pro Gly Lys Val Val
    1010                1015                1020

 aac tac cgt gtt gtc tat cgc cct cat ggg aga ggg aag caa atg gtt     3120
 Asn Tyr Arg Val Val Tyr Arg Pro His Gly Arg Gly Lys Gln Met Val
1025                1030                1035                1040

 gct aag gtg ccc ccc aca gtc act tcg aca gtg tta aag cga ctt cag     3168
 Ala Lys Val Pro Pro Thr Val Thr Ser Thr Val Leu Lys Arg Leu Gln
                1045                1050                1055

 cca cag acc aca tat gac atc aca gtt ctt cct att tac aag atg gga     3216
 Pro Gln Thr Thr Tyr Asp Ile Thr Val Leu Pro Ile Tyr Lys Met Gly
            1060                1065                1070

 gaa gga aag ctt agg caa gga tca gga aca aca gct tct cgg ttt aag     3264
 Glu Gly Lys Leu Arg Gln Gly Ser Gly Thr Thr Ala Ser Arg Phe Lys
        1075                1080                1085

 tct cct aga aac ctc aaa aca tct gac cca acc atg tca agc ttc cga     3312
 Ser Pro Arg Asn Leu Lys Thr Ser Asp Pro Thr Met Ser Ser Phe Arg
    1090                1095                1100

 gtg act tgg gag cct gcc cct ggg gaa gtg aag ggt tat aaa gtc aca     3360
 Val Thr Trp Glu Pro Ala Pro Gly Glu Val Lys Gly Tyr Lys Val Thr
1105                1110                1115                1120

 ttc cac cct acg ggg gat gac aga aga ctg ggg gag tta gtg gtt gga     3408
 Phe His Pro Thr Gly Asp Asp Arg Arg Leu Gly Glu Leu Val Val Gly
                1125                1130                1135

 ccc tat gac aac aca gtt gtt ttg gag gaa ctt agg gct ggt acc acc     3456
 Pro Tyr Asp Asn Thr Val Val Leu Glu Glu Leu Arg Ala Gly Thr Thr
            1140                1145                1150

 tat aaa gta aat gtt ttt gga atg ttt gat gga gga gaa agc tca cca     3504
 Tyr Lys Val Asn Val Phe Gly Met Phe Asp Gly Gly Glu Ser Ser Pro
        1155                1160                1165

 ctt gtt gga caa gaa atg aca acc ctt tcc gac aca act gtt atg cca     3552
 Leu Val Gly Gln Glu Met Thr Thr Leu Ser Asp Thr Thr Val Met Pro
    1170                1175                1180

 att tta tct tct ggg atg gag tgt ctc acc aga gct gag gca gac att     3600
 Ile Leu Ser Ser Gly Met Glu Cys Leu Thr Arg Ala Glu Ala Asp Ile
1185                1190                1195                1200

 gtg ttg ctg gtg gat gga tca tgg agc atc ggc cgg gca aat ttt aga     3648
 Val Leu Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Ala Asn Phe Arg
                1205                1210                1215

 acc gtg agg agt ttc att tct cgt att gtg gaa gtc ttt gac att ggc     3696
 Thr Val Arg Ser Phe Ile Ser Arg Ile Val Glu Val Phe Asp Ile Gly
            1220                1225                1230

 ccc aaa aga gta caa att gct ctt gct cag tat agt ggg gat ccc aga     3744
 Pro Lys Arg Val Gln Ile Ala Leu Ala Gln Tyr Ser Gly Asp Pro Arg
        1235                1240                1245

 aca gag tgg cag tta aat gca cac aga gac aag aag agc ttg ttg caa     3792
 Thr Glu Trp Gln Leu Asn Ala His Arg Asp Lys Lys Ser Leu Leu Gln
    1250                1255                1260

 gct gtg gca aac ttg ccg tac aaa gga ggc aat act ctc aca ggc atg     3840
 Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Met
1265                1270                1275                1280

 gct ttg aat ttc att cgc caa cag aac ttc agg acc caa gct ggc atg     3888
 Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe Arg Thr Gln Ala Gly Met
                1285                1290                1295

 aga cct cga gct cga aaa att ggt gtg ctc att act gat gga aaa tca     3936
 Arg Pro Arg Ala Arg Lys Ile Gly Val Leu Ile Thr Asp Gly Lys Ser
            1300                1305                1310

 caa gac gat gtt gaa gca cct tca aag aaa ctc aag gat gag gga gtg     3984
 Gln Asp Asp Val Glu Ala Pro Ser Lys Lys Leu Lys Asp Glu Gly Val
        1315                1320                1325

 gag ctg ttt gct att ggt att aaa aat gct gat gaa gtc gaa tta aag     4032
 Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala Asp Glu Val Glu Leu Lys
    1330                1335                1340

 atg att gca act gat cct gat gat acc cat gac tac aat gtg gca gat     4080
 Met Ile Ala Thr Asp Pro Asp Asp Thr His Asp Tyr Asn Val Ala Asp
1345                1350                1355                1360

 ttt gag tca ctc tcc agg ata gtg gat gat ctc acc att aat ttg tgt     4128
 Phe Glu Ser Leu Ser Arg Ile Val Asp Asp Leu Thr Ile Asn Leu Cys
                1365                1370                1375

 aac agt gtc aaa ggt cca ggt gat ttg gaa gca cct tct aac tta gtt     4176
 Asn Ser Val Lys Gly Pro Gly Asp Leu Glu Ala Pro Ser Asn Leu Val
            1380                1385                1390

 att tct gag cga acc cat cgt tct ttt aga gtg agc tgg aca cca cct     4224
 Ile Ser Glu Arg Thr His Arg Ser Phe Arg Val Ser Trp Thr Pro Pro
        1395                1400                1405

 tct gac agt gtg gat cga tat aag gtg gaa tac tat cca gtt tct gga     4272
 Ser Asp Ser Val Asp Arg Tyr Lys Val Glu Tyr Tyr Pro Val Ser Gly
    1410                1415                1420

 ggg aaa cgt caa gaa ttt tat gtg agt cga atg gaa act agc aca gtg     4320
 Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg Met Glu Thr Ser Thr Val
1425                1430                1435                1440

 ctg aaa gat ctg aaa cct gaa act gaa tat gtt gtc aat gtg tat tct     4368
 Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr Val Val Asn Val Tyr Ser
                1445                1450                1455

 gtg gta gaa gat gaa tat agt gag cct ctg aag ggg aca gaa aaa acc     4416
 Val Val Glu Asp Glu Tyr Ser Glu Pro Leu Lys Gly Thr Glu Lys Thr
            1460                1465                1470

 ttg cca gtg cct gta gtc agc ctg aat att tat gat gtt ggc cct acc     4464
 Leu Pro Val Pro Val Val Ser Leu Asn Ile Tyr Asp Val Gly Pro Thr
        1475                1480                1485

 acc atg cat gtg cag tgg cag cct gtg gga gga gct act ggc tac atc     4512
 Thr Met His Val Gln Trp Gln Pro Val Gly Gly Ala Thr Gly Tyr Ile
    1490                1495                1500

 ttg tca tac aaa cct gtt aag gac aca gag cca aca aga ccc aaa gag     4560
 Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu Pro Thr Arg Pro Lys Glu
1505                1510                1515                1520

 gtg cgt ttg ggg cca aca gtg aat gac atg cag ctg act gac ctt gtt     4608
 Val Arg Leu Gly Pro Thr Val Asn Asp Met Gln Leu Thr Asp Leu Val
                1525                1530                1535

 ccc aac acg gag tat gca gtc aca gtc cag gct gtc ctg cac gac ctc     4656
 Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val Leu His Asp Leu
            1540                1545                1550

 act agt gaa cct gtc act gtt cgg gaa gtc acc ttg cct tta ccc aga     4704
 Thr Ser Glu Pro Val Thr Val Arg Glu Val Thr Leu Pro Leu Pro Arg
        1555                1560                1565

 cct cag gat ctg aaa ctc aga gat gtg act cac agc act atg aat gtc     4752
 Pro Gln Asp Leu Lys Leu Arg Asp Val Thr His Ser Thr Met Asn Val
    1570                1575                1580

 ttt tgg gaa cct gtg cct gga aaa gtg cgt aaa tat att gtt cga tac     4800
 Phe Trp Glu Pro Val Pro Gly Lys Val Arg Lys Tyr Ile Val Arg Tyr
1585                1590                1595                1600

 aaa aca cca gaa gag gat gtc aaa gag gta gag gtg gac aga tca gag     4848
 Lys Thr Pro Glu Glu Asp Val Lys Glu Val Glu Val Asp Arg Ser Glu
                1605                1610                1615

 acc agc act tcc ctc aaa gac ctc ttc tca cag acc ttg tac aca gtc     4896
 Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser Gln Thr Leu Tyr Thr Val
            1620                1625                1630

 agc gtt tct gca gta cat gac gag ggg gag tct cct cca gtg act gct     4944
 Ser Val Ser Ala Val His Asp Glu Gly Glu Ser Pro Pro Val Thr Ala
        1635                1640                1645

 caa gaa act acc cga ccc gtg cca gcc cca aca aac tta aag att act     4992
 Gln Glu Thr Thr Arg Pro Val Pro Ala Pro Thr Asn Leu Lys Ile Thr
    1650                1655                1660

 gaa gta aca tca gag ggt ttc aga ggg act tgg gat cat gga gct tca     5040
 Glu Val Thr Ser Glu Gly Phe Arg Gly Thr Trp Asp His Gly Ala Ser
1665                1670                1675                1680

 gat gtg tct ctc tac aga ata act tgg gga cct ttt gga agc tca gat     5088
 Asp Val Ser Leu Tyr Arg Ile Thr Trp Gly Pro Phe Gly Ser Ser Asp
                1685                1690                1695

 aag atg gag acc atc tta aat gga gat gaa aac act ttg gtg ttc gaa     5136
 Lys Met Glu Thr Ile Leu Asn Gly Asp Glu Asn Thr Leu Val Phe Glu
            1700                1705                1710

 aac ctg aac ccc aac acc atc tat gaa gtt tcc att act gcc atc tat     5184
 Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val Ser Ile Thr Ala Ile Tyr
        1715                1720                1725

 gct gat gag tca gaa agt gat gac ctg att ggc agt gag cgc act ctg     5232
 Ala Asp Glu Ser Glu Ser Asp Asp Leu Ile Gly Ser Glu Arg Thr Leu
    1730                1735                1740

 cct atc tta aca aca caa gct ccc aaa agt ggg cca cga aac ctt caa     5280
 Pro Ile Leu Thr Thr Gln Ala Pro Lys Ser Gly Pro Arg Asn Leu Gln
1745                1750                1755                1760

 gtg tac aat gca aca tct aac agc ctg act gtt aag tgg gat cct gct     5328
 Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys Trp Asp Pro Ala
                1765                1770                1775

 agt ggt cgt gtg cag aaa tat agg atc act tat cag cct tcc aca ggg     5376
 Ser Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln Pro Ser Thr Gly
            1780                1785                1790

 gaa ggc aat gag caa acg acc aca ata gga gga cgg cag aac agt gtg     5424
 Glu Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg Gln Asn Ser Val
        1795                1800                1805

 gtc ctg cag aaa ctg aag cca gac act cct tac act atc acc gta tcc     5472
 Val Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr Ile Thr Val Ser
    1810                1815                1820

 tct ctg tat cct gat ggt gaa gga ggt cgg atg acg gga aga ggc aag     5520
 Ser Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr Gly Arg Gly Lys
1825                1830                1835                1840

 acc aaa cct cta aac act gta agg aac ctg aga gtg tat gac cct tct     5568
 Thr Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val Tyr Asp Pro Ser
                1845                1850                1855

 acc agc act ctg aat gtc cgc tgg gac cat gca gag gga aat cct cgt     5616
 Thr Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu Gly Asn Pro Arg
            1860                1865                1870

 cag tac aag ctc ttc tat gca cca gca gca ggt ggt cca gag gaa ctg     5664
 Gln Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly Pro Glu Glu Leu
        1875                1880                1885

 gta cca atc ccc ggg aat acc aat tat gcc att ctt agg aat ctg cag     5712
 Val Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu Arg Asn Leu Gln
    1890                1895                1900

 cca gat acc tca tac act gtg act gta gtt ccc gtt tat act gaa ggt     5760
 Pro Asp Thr Ser Tyr Thr Val Thr Val Val Pro Val Tyr Thr Glu Gly
1905                1910                1915                1920

 gat ggg gga cgc aca tca gat act gga agg aca ttg atg aga gga ctg     5808
 Asp Gly Gly Arg Thr Ser Asp Thr Gly Arg Thr Leu Met Arg Gly Leu
                1925                1930                1935

 gca aga aat gtc caa gta tac aat cct aca cct aac agg ctc ggt gtt     5856
 Ala Arg Asn Val Gln Val Tyr Asn Pro Thr Pro Asn Arg Leu Gly Val
            1940                1945                1950

 cgc tgg gac cct gca cca gga cct gtg ctg caa tat cgc gtt gtg tat     5904
 Arg Trp Asp Pro Ala Pro Gly Pro Val Leu Gln Tyr Arg Val Val Tyr
        1955                1960                1965

 tct cct gtg gat ggc aca aga ccc tca gaa tct ata gta gtg cca gga     5952
 Ser Pro Val Asp Gly Thr Arg Pro Ser Glu Ser Ile Val Val Pro Gly
    1970                1975                1980

 aac acg cgc atg gtg cat ctg gag cgg ctg att ccg gac aca ctc tat     6000
 Asn Thr Arg Met Val His Leu Glu Arg Leu Ile Pro Asp Thr Leu Tyr
1985                1990                1995                2000

 tcc gtg aac ctt gtg gct ctg tac tcg gat gga gag gga aat ccc agc     6048
 Ser Val Asn Leu Val Ala Leu Tyr Ser Asp Gly Glu Gly Asn Pro Ser
                2005                2010                2015

 cct gcc cag ggc cga acg cta cca cgc agt gga cca agg aac ctg aga     6096
 Pro Ala Gln Gly Arg Thr Leu Pro Arg Ser Gly Pro Arg Asn Leu Arg
            2020                2025                2030

 gtc ttt ggt gaa aca acc aat agc ctc tcg gta gcc tgg gat cat gct     6144
 Val Phe Gly Glu Thr Thr Asn Ser Leu Ser Val Ala Trp Asp His Ala
        2035                2040                2045

 gat ggg cca gtt cag cag tac agg atc atc tat tct ccc act gtt ggt     6192
 Asp Gly Pro Val Gln Gln Tyr Arg Ile Ile Tyr Ser Pro Thr Val Gly
    2050                2055                2060

 gat cca att gat gaa tat acc aca gtc cca ggc aga aga aac aat gta     6240
 Asp Pro Ile Asp Glu Tyr Thr Thr Val Pro Gly Arg Arg Asn Asn Val
2065                2070                2075                2080

 ata ctg cag ccc ctg caa cct gac act cca tat aaa att act gtt att     6288
 Ile Leu Gln Pro Leu Gln Pro Asp Thr Pro Tyr Lys Ile Thr Val Ile
                2085                2090                2095

 gct gtt tat gaa gat gga gat ggt ggc cat cta aca gga aat gga aga     6336
 Ala Val Tyr Glu Asp Gly Asp Gly Gly His Leu Thr Gly Asn Gly Arg
            2100                2105                2110

 act gtg gga ctc ctt cct cct cag aac ata cac atc tct gac gaa tgg     6384
 Thr Val Gly Leu Leu Pro Pro Gln Asn Ile His Ile Ser Asp Glu Trp
        2115                2120                2125

 tat aca aga ttc agg gtg tcc tgg gat cct tca cct tct cca gtt ctt     6432
 Tyr Thr Arg Phe Arg Val Ser Trp Asp Pro Ser Pro Ser Pro Val Leu
    2130                2135                2140

 gga tat aaa ata gta tat aag cca gtg ggt tcc aat gag ccc atg gaa     6480
 Gly Tyr Lys Ile Val Tyr Lys Pro Val Gly Ser Asn Glu Pro Met Glu
2145                2150                2155                2160

 gcc ttt gtt gga gaa atg aca tca tat acc tta cac aat ctc aat ccc     6528
 Ala Phe Val Gly Glu Met Thr Ser Tyr Thr Leu His Asn Leu Asn Pro
                2165                2170                2175

 agc acc acc tac gat gtg aat gtt tat gct caa tat gat tct gga ctc     6576
 Ser Thr Thr Tyr Asp Val Asn Val Tyr Ala Gln Tyr Asp Ser Gly Leu
            2180                2185                2190

 agt gtc ccc ttg aca gat caa ggc act aca tta tat tta aat gta aca     6624
 Ser Val Pro Leu Thr Asp Gln Gly Thr Thr Leu Tyr Leu Asn Val Thr
        2195                2200                2205

 gat ctg aaa act tac cag att ggg tgg gat aca ttc tgt gtc aaa tgg     6672
 Asp Leu Lys Thr Tyr Gln Ile Gly Trp Asp Thr Phe Cys Val Lys Trp
    2210                2215                2220

 tca cct cac cgg gca gcc acc tcc tac agg cta aaa cta agc cct gca     6720
 Ser Pro His Arg Ala Ala Thr Ser Tyr Arg Leu Lys Leu Ser Pro Ala
2225                2230                2235                2240

 gat gga acc agg gga caa gaa att aca gtg cgt gga tca gaa acc agt     6768
 Asp Gly Thr Arg Gly Gln Glu Ile Thr Val Arg Gly Ser Glu Thr Ser
                2245                2250                2255

 cac tgc ttc act ggc ctt tca cca gac act gat tat ggt gtc act gtt     6816
 His Cys Phe Thr Gly Leu Ser Pro Asp Thr Asp Tyr Gly Val Thr Val
            2260                2265                2270

 ttt gtg cag aca cca aat ctc gag gga cca gga gtc tct gtt aaa gaa     6864
 Phe Val Gln Thr Pro Asn Leu Glu Gly Pro Gly Val Ser Val Lys Glu
        2275                2280                2285

 cat acc act gtg aaa cca aca gaa gcc cct aca gag cca ccc aca cct     6912
 His Thr Thr Val Lys Pro Thr Glu Ala Pro Thr Glu Pro Pro Thr Pro
    2290                2295                2300

 cct ccc cct ccc acc att cca cca gcc cgg gat gta tgc aaa ggg gcc     6960
 Pro Pro Pro Pro Thr Ile Pro Pro Ala Arg Asp Val Cys Lys Gly Ala
2305                2310                2315                2320

 aag gca gat att gtg ttc ttg act gat gcc tcc tgg agc att ggg gac     7008
 Lys Ala Asp Ile Val Phe Leu Thr Asp Ala Ser Trp Ser Ile Gly Asp
                2325                2330                2335

 gat aat ttt aac aaa gtt gta aaa ttc atc ttc aat act gtg gga ggc     7056
 Asp Asn Phe Asn Lys Val Val Lys Phe Ile Phe Asn Thr Val Gly Gly
            2340                2345                2350

 ttt gat gaa atc agt cct gct ggg att cag gtt tca ttt gtg caa tac     7104
 Phe Asp Glu Ile Ser Pro Ala Gly Ile Gln Val Ser Phe Val Gln Tyr
        2355                2360                2365

 agc gat gag gtc aag tct gag ttc aag ctg aac acg tac aat gac aag     7152
 Ser Asp Glu Val Lys Ser Glu Phe Lys Leu Asn Thr Tyr Asn Asp Lys
    2370                2375                2380

 gcc cta gcc ctt ggg gcc ctc cag aat att agg tac aga gga gga aac     7200
 Ala Leu Ala Leu Gly Ala Leu Gln Asn Ile Arg Tyr Arg Gly Gly Asn
2385                2390                2395                2400

 aca aga aca ggc aag gcc ctc acg ttt atc aag gag aaa gtc ttg act     7248
 Thr Arg Thr Gly Lys Ala Leu Thr Phe Ile Lys Glu Lys Val Leu Thr
                2405                2410                2415

 tgg gag agc ggc atg agg aag aat gtc cct aag gtg ttg gtt gtg gtc     7296
 Trp Glu Ser Gly Met Arg Lys Asn Val Pro Lys Val Leu Val Val Val
            2420                2425                2430

 acg gac ggt cgg tcc cag gat gag gtc aag aag gcg gct ttg gtc atc     7344
 Thr Asp Gly Arg Ser Gln Asp Glu Val Lys Lys Ala Ala Leu Val Ile
        2435                2440                2445

 cag cag tca ggg ttc agt gtc ttt gta gtt ggt gtg gct gat gtc gac     7392
 Gln Gln Ser Gly Phe Ser Val Phe Val Val Gly Val Ala Asp Val Asp
    2450                2455                2460

 tac aat gag ctt gcc aac att gcc agc aaa cca agt gaa cgg cac gtg     7440
 Tyr Asn Glu Leu Ala Asn Ile Ala Ser Lys Pro Ser Glu Arg His Val
2465                2470                2475                2480

 ttc att gtg gac gac ttt gaa tct ttt gag aag atc gaa gac aat ctt     7488
 Phe Ile Val Asp Asp Phe Glu Ser Phe Glu Lys Ile Glu Asp Asn Leu
                2485                2490                2495

 att aca ttt gtt tgt gaa act gcc act tca agt tgt cct ctc att tat     7536
 Ile Thr Phe Val Cys Glu Thr Ala Thr Ser Ser Cys Pro Leu Ile Tyr
            2500                2505                2510

 ttg gat ggc tac acc tca cca ggt ttt aaa atg ctt gaa gca tac aac     7584
 Leu Asp Gly Tyr Thr Ser Pro Gly Phe Lys Met Leu Glu Ala Tyr Asn
        2515                2520                2525

 ctg aca gaa aag aat ttt gct tct gta caa gga gta tct ttg gag tca     7632
 Leu Thr Glu Lys Asn Phe Ala Ser Val Gln Gly Val Ser Leu Glu Ser
    2530                2535                2540

 ggg tct ttc ccc agc tac tca gca tac agg att cag aag aat gcg ttt     7680
 Gly Ser Phe Pro Ser Tyr Ser Ala Tyr Arg Ile Gln Lys Asn Ala Phe
2545                2550                2555                2560

 gtg aat cag cct aca gca gac cta cac cca aat gga ctc cct cct tca     7728
 Val Asn Gln Pro Thr Ala Asp Leu His Pro Asn Gly Leu Pro Pro Ser
                2565                2570                2575

 tac acg att ata tta tta ttc aga ctt ctc cca gaa act ccc agt gac     7776
 Tyr Thr Ile Ile Leu Leu Phe Arg Leu Leu Pro Glu Thr Pro Ser Asp
            2580                2585                2590

 cct ttt gca att tgg caa atc aca gac aga gac tac aaa cca caa gtt     7824
 Pro Phe Ala Ile Trp Gln Ile Thr Asp Arg Asp Tyr Lys Pro Gln Val
        2595                2600                2605

 gga gtg att gca gat cct tct agc aag acg tta tca ttc ttt aac aag     7872
 Gly Val Ile Ala Asp Pro Ser Ser Lys Thr Leu Ser Phe Phe Asn Lys
    2610                2615                2620

 gat aca aga ggc gag gtg caa act gtt aca ttt gac aca gaa gaa gta     7920
 Asp Thr Arg Gly Glu Val Gln Thr Val Thr Phe Asp Thr Glu Glu Val
2625                2630                2635                2640

 aag aca tta ttt tat gga agt ttt cac aag gtt cat att gta gtg acc     7968
 Lys Thr Leu Phe Tyr Gly Ser Phe His Lys Val His Ile Val Val Thr
                2645                2650                2655

 tca aaa agt gtt aag att tac att gac tgc tat gaa att ata gaa aaa     8016
 Ser Lys Ser Val Lys Ile Tyr Ile Asp Cys Tyr Glu Ile Ile Glu Lys
            2660                2665                2670

 gac atc aag gaa gct gga aat ata aca act gat ggt tat gaa att ctt     8064
 Asp Ile Lys Glu Ala Gly Asn Ile Thr Thr Asp Gly Tyr Glu Ile Leu
        2675                2680                2685

 gga aaa ctc ctt aaa ggg gaa agg aaa tca gcc gca ttc caa atc cag     8112
 Gly Lys Leu Leu Lys Gly Glu Arg Lys Ser Ala Ala Phe Gln Ile Gln
    2690                2695                2700

 agt ttt gac att gtc tgc agt cca gtg tgg acc agt aga gac aga tgc     8160
 Ser Phe Asp Ile Val Cys Ser Pro Val Trp Thr Ser Arg Asp Arg Cys
2705                2710                2715                2720

 tgt gat att ccc tct agg aga gat gag gga aaa tgc cct gct ttt cca     8208
 Cys Asp Ile Pro Ser Arg Arg Asp Glu Gly Lys Cys Pro Ala Phe Pro
                2725                2730                2735

 aat tct tgc aca tgt aca cag gac agc gtt gga cct cca gga cct cca     8256
 Asn Ser Cys Thr Cys Thr Gln Asp Ser Val Gly Pro Pro Gly Pro Pro
            2740                2745                2750

 ggc cct gca gga gga cct ggt gct aaa ggt ccc aga ggt gaa aga ggt     8304
 Gly Pro Ala Gly Gly Pro Gly Ala Lys Gly Pro Arg Gly Glu Arg Gly
        2755                2760                2765

 atc agt ggg gca att ggg ccc cct ggt cct cgt gga gac ata ggt cct     8352
 Ile Ser Gly Ala Ile Gly Pro Pro Gly Pro Arg Gly Asp Ile Gly Pro
    2770                2775                2780

 cca ggc ccc cag ggt cct cca ggc cct cag gga ccc aat gga ctc tct     8400
 Pro Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly Pro Asn Gly Leu Ser
2785                2790                2795                2800

 att ccg gga gag caa ggt cgc caa ggg atg aaa ggt gat gct gga gag     8448
 Ile Pro Gly Glu Gln Gly Arg Gln Gly Met Lys Gly Asp Ala Gly Glu
                2805                2810                2815

 cca gga ctt cca ggc cga aca gga acc cca gga tta cct ggc cca cca     8496
 Pro Gly Leu Pro Gly Arg Thr Gly Thr Pro Gly Leu Pro Gly Pro Pro
            2820                2825                2830

 gga cca atg gga cct cca gga gac aga ggc ttc act gga aaa gac agt     8544
 Gly Pro Met Gly Pro Pro Gly Asp Arg Gly Phe Thr Gly Lys Asp Ser
        2835                2840                2845

 gca atg gga ccc agg ggc cca cca ggg cgg ccg gga agc cca ggc tcc     8592
 Ala Met Gly Pro Arg Gly Pro Pro Gly Arg Pro Gly Ser Pro Gly Ser
    2850                2855                2860

 cca gga gtc aca gga cca agt ggg aag cca gga aaa cct gga gat cat     8640
 Pro Gly Val Thr Gly Pro Ser Gly Lys Pro Gly Lys Pro Gly Asp His
2865                2870                2875                2880

 ggc aga cca ggt cca tct ggg ttg aaa gga gaa aaa ggt gat agg gga     8688
 Gly Arg Pro Gly Pro Ser Gly Leu Lys Gly Glu Lys Gly Asp Arg Gly
                2885                2890                2895

 gac att gct tcc cag aac atg atg cga gca gtt gca aga caa gtc tgt     8736
 Asp Ile Ala Ser Gln Asn Met Met Arg Ala Val Ala Arg Gln Val Cys
            2900                2905                2910

 gaa caa ttg ata agt ggt cag atg aac aga ttc aat cag atg ctg aat     8784
 Glu Gln Leu Ile Ser Gly Gln Met Asn Arg Phe Asn Gln Met Leu Asn
        2915                2920                2925

 cag att cca aat gat tac cag tcc agt cgc aac cag cca ggc ccg ccg     8832
 Gln Ile Pro Asn Asp Tyr Gln Ser Ser Arg Asn Gln Pro Gly Pro Pro
    2930                2935                2940

 ggt cca ccg gga cct cct ggt agc gca gga gcc aga gga gaa cct ggg     8880
 Gly Pro Pro Gly Pro Pro Gly Ser Ala Gly Ala Arg Gly Glu Pro Gly
2945                2950                2955                2960

 cct ggg ggg cgg cca ggc ttc ccg ggc aca cca ggg atg cag gga ccc     8928
 Pro Gly Gly Arg Pro Gly Phe Pro Gly Thr Pro Gly Met Gln Gly Pro
                2965                2970                2975

 cct ggg gaa cga ggt ttg cca gga gag aaa ggt gaa agg ggt act gga     8976
 Pro Gly Glu Arg Gly Leu Pro Gly Glu Lys Gly Glu Arg Gly Thr Gly
            2980                2985                2990

 tct tca gga cct cgg ggg ctg cct ggg ccc cca ggt cca caa gga gaa     9024
 Ser Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Gln Gly Glu
        2995                3000                3005

 tcc aga aca ggt cca cca ggg tcc aca ggt tca aga ggt ccc cct ggc     9072
 Ser Arg Thr Gly Pro Pro Gly Ser Thr Gly Ser Arg Gly Pro Pro Gly
    3010                3015                3020

 ccc cct ggc cgt cct gga aac tca ggt atc cag ggc ccc cca ggt cct     9120
 Pro Pro Gly Arg Pro Gly Asn Ser Gly Ile Gln Gly Pro Pro Gly Pro
3025                3030                3035                3040

 cct gga tac tgt gat tct tct cag tgt gcc agc atc cca tac aac ggg     9168
 Pro Gly Tyr Cys Asp Ser Ser Gln Cys Ala Ser Ile Pro Tyr Asn Gly
                3045                3050                3055

 caa ggc tat cca gag cct tac gtg ccc gag ggc ggg gcc tac ctg cct     9216
 Gln Gly Tyr Pro Glu Pro Tyr Val Pro Glu Gly Gly Ala Tyr Leu Pro
            3060                3065                3070

 gag cgc gag ccc ttc atc gtg ccg gtg gag ccc gag cgg aca gcg gaa     9264
 Glu Arg Glu Pro Phe Ile Val Pro Val Glu Pro Glu Arg Thr Ala Glu
        3075                3080                3085

 tac gag gac tac ggc gca gac gag cct gca gag gag cct cct gag ccc     9312
 Tyr Glu Asp Tyr Gly Ala Asp Glu Pro Ala Glu Glu Pro Pro Glu Pro
    3090                3095                3100

 cac cgg cgc tgg cgg cgc gcc ctg ccc cac gga ccc ggg cag tgaacca     9361
 His Arg Arg Trp Arg Arg Ala Leu Pro His Gly Pro Gly Gln 
3105                3110                3115

 gagatcacgc gccgcgccgc gaggcttggg ggaggtgttg aaattctcat ttacaggtca   9421

 gatagagcag tgtacgtctt ttctgaggtg tttcttccag cgttgctcat ccaggagtac   9481

 cc                                                                  9483




      <210> 116
      <211> 427
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (266)..(364)

      <400> 116
 tccctctggg aaaaagcttc cagaggaagg agcaggcagt aatttttgct gttctgcagc     60

 ctccgctggt gatatcgagg caaacagggt ctgcagtgga cctccagcaa acaccagcag    120

 gcctgcagaa gaggggcctg actattagaa ggaaaactaa caaatagaaa gcagtagcct    180

 caacgtcaac aaaaaggaca accacacaaa aaccccatct gaaggtcacc agcatcaaag    240

 accaaaggta gataaatccc tgaag  atg agg aaa aag cag cgc aaa aag gct     292
                              Met Arg Lys Lys Gln Arg Lys Lys Ala
                                1               5

 gaa aat tcc aaa aac cag aat gcc tct tct cct cca aag gag cac aac      340
 Glu Asn Ser Lys Asn Gln Asn Ala Ser Ser Pro Pro Lys Glu His Asn
  10                  15                  20                  25

 tcc tcg cca gca aag gaa caa aac tgaacagaga atgagtttga tgaattgaca     394
 Ser Ser Pro Ala Lys Glu Gln Asn 
                  30

 gaagtaggct tcagaaggta ggtaataaca gag                                 427




      <210> 117
      <211> 640
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (464)..(553)

      <400> 117
 gccctgggcc aaatgtgcct gatgggaaca gacttgcagg gccatgcagg ccagacttcg     60

 tgccttaact gaagagtgtg cgtgtgtgtg tgtgagagag agagagagag agaaacacgc    120

 atcatgggtc cctgatctat gaaatgaaca caacctctct gaggctggat gatctggagg    180

 aagggggcat ggagcaaatt tgaggctctg attgctgagc cagcctcctc ccaggcggtt    240

 tccccaggac tctcgtagga aataaatagc cctttcaaga ttcctcagct gcctcacccc    300

 ctgcacatgt gcctggggtg tggcctagaa gggagtgatg ttcttactct ggtggtctgt    360

 gcttctgaac acaggctaca tgcacacact gacaactacc aataaacaga caggggaagg    420

 tctttcatct cagccatttt ctcttccccc cgccccccct tag  atg gag tct tgc     475
                                                  Met Glu Ser Cys
                                                    1

 tct gtc acc cag gtt gga gtg cag tgg cac aat cag ctc act gca acc      523
 Ser Val Thr Gln Val Gly Val Gln Trp His Asn Gln Leu Thr Ala Thr
   5                  10                  15                  20

 cct cct cct agg ttc aag cga ttg agt agc t gagattacag gcatgcatca      574
 Pro Pro Pro Arg Phe Lys Arg Leu Ser Ser 
                  25                  30

 ctatgcctgg ctttttgtat tttttagtag agatggggtt taccatgttg ggccaggcta    634

 gtctca                                                               640




      <210> 118
      <211> 481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (130)..(285)

      <220>
      <221> misc_feature
      <222> (1)...(481)
      <223> n = a,t,c or g

      <400> 118
 agggatgccg gggtccgnna actgatgccc ctgnagcgat cgtacggnct caannnatgg     60

 gncgacccac gcgtccgccc acgcgtncgg cacaagaaaa gatgcttaac atatttaacc    120

 attaaataa    atg caa att aaa acc aag atg aga tat cac ttc aca cac     168
              Met Gln Ile Lys Thr Lys Met Arg Tyr His Phe Thr His
                1               5                  10

 tct agg atg ttt ata gtt aaa aaa gat agt aaa tgc tgg caa ata tgt      216
 Ser Arg Met Phe Ile Val Lys Lys Asp Ser Lys Cys Trp Gln Ile Cys
      15                  20                  25

 gga gaa att gaa atc ctc aca cac tgc tgt tgg aaa tgt aca atg gta      264
 Gly Glu Ile Glu Ile Leu Thr His Cys Cys Trp Lys Cys Thr Met Val
  30                  35                  40                  45

 cag tca ctt tgg aaa ata gtc ta accgttcctc aaaatgatgg agaaaatgag      317
 Gln Ser Leu Trp Lys Ile Val 
                  50

 gagtgagttc taataggtat gggcttcctt tgggggtgat gaaaatgttc ttaaattgat    377

 catggtaatg gttgcacaac cctgtgcata tactaaaacc cattaaattt tgtacttaaa    437

 ttgggtgaat tgtggaataa tattgttaat aatatctcaa taan                     481




      <210> 119
      <211> 1319
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (948)..(1106)

      <400> 119
 tttttttttt ttgccattga gttgttggag tttcttatac attttggata ctagcccttt     60

 tatcagatat atggtttgca aatattctct tcccctctgt aggttgcttt ttcattctga    120

 ttatttccct tgctgtgcag acacttttta gtttgacgtt gtccaacttg tttgttttgc    180

 ttttgttgcc tgtgcttttg gtgtcacatc taaaatatca ttgctttttc cctatgtttt    240

 ttttctagga gttttacagt ttcaggtcct gtgtttaagt ctttaatcca tgggtagatg    300

 gccaaaagga cgaagtcagg atctcaaaga ggtatctgta cccccgtgtt cactgaagca    360

 ttattcataa tggccaagat acggaaacaa ctcatgtgtc tactgacaga agaatggatc    420

 aagaaaatgg agtatattct gaccgggcac gctggctcac gcctgtaatc ccatcaattt    480

 agaaggccaa ggcaggtgaa tctcttgagg ccaggagttc gagaccagcc tgggcctccc    540

 agagtgctgg gattgcaggt gtgagccact gcgcccggcc cctggctttg ggttttctgc    600

 tcaccttcct ccttccctcc cacaaatact atgtgtccca aatgtgccgg gatccatgcc    660

 ttgtgctggg gacacagagg ggaccgatgc catcctggtc atgggggagg atgtggcatt    720

 ttcatgaaga gctatgatcg agggggcccc acggttgctt caggagccca gagtaggcat    780

 ctgaccctgc caggcgtgct cccagacaag gtgacaatgg tgctgaggtg cccgagagga    840

 atgagcctca gatactggac tgtcagacgt ggacatgggg gtaagcacag ggtccctacc    900

 ttgcaaggca cgagcccctg acagcctctt ctctttccag gtcagcc  atg tca tct     956
                                                      Met Ser Ser
                                                        1

 gag cct ccc cca cca cca cag ccc ccc acc cat caa gct tca gtc ggg     1004
 Glu Pro Pro Pro Pro Pro Gln Pro Pro Thr His Gln Ala Ser Val Gly
       5                  10                  15

 ctg ctg gac acc cct cgg agc cgt gag cgc tca cca tcc cct ctg cgc     1052
 Leu Leu Asp Thr Pro Arg Ser Arg Glu Arg Ser Pro Ser Pro Leu Arg
  20                  25                  30                  35

 ggc aac gtg gtc cca agc cca ctg ccc act cgc cgg acg agg acc ttc     1100
 Gly Asn Val Val Pro Ser Pro Leu Pro Thr Arg Arg Thr Arg Thr Phe
                  40                  45                  50

 tcg gcg tgagtctgga gcaaggctgg ggacgcgttc tcagatggat ctcttgcctg      1156
 Ser Ala 


 aggccagaga ttcactgtgt ctctggccat ttttgggcct atgtcccgga ctgccaaata   1216

 ggcagacctg gggctgggcc gtgggctgag ggtgagaaac taggaaggcg ccttgtaaat   1276

 tcagggtact gcccagccca gaagaacctg ttaccagctg gga                     1319




      <210> 120
      <211> 1555
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(1486)

      <400> 120
 ttggcacgag ggtagtgggg gctgcagctg ccggacccag gcactgaccc ttgacctccg     60

 gtggctcccc catctctcag gcgcg  atg gct acg ggc gcg gat gta cgg gac     112
                              Met Ala Thr Gly Ala Asp Val Arg Asp
                                1               5

 att cta gaa ctc ggg ggt cca gaa ggg gat gca gcc tct ggg acc atc      160
 Ile Leu Glu Leu Gly Gly Pro Glu Gly Asp Ala Ala Ser Gly Thr Ile
  10                  15                  20                  25

 agc aag aag gac att atc aac ccg gac aag aaa aaa tcc aag aag tcc      208
 Ser Lys Lys Asp Ile Ile Asn Pro Asp Lys Lys Lys Ser Lys Lys Ser
                  30                  35                  40

 tct gag aca ctg act ttc aag agg ccc gag ggc atg cac cgg gaa gtc      256
 Ser Glu Thr Leu Thr Phe Lys Arg Pro Glu Gly Met His Arg Glu Val
              45                  50                  55

 tat gcc ttg ctc tac tct gac aag aag gat gca ccc cca ctg cta ccc      304
 Tyr Ala Leu Leu Tyr Ser Asp Lys Lys Asp Ala Pro Pro Leu Leu Pro
          60                  65                  70

 agt gac act ggc cag gga tac cgt aca gtg aag gcc aag ttg ggc tcc      352
 Ser Asp Thr Gly Gln Gly Tyr Arg Thr Val Lys Ala Lys Leu Gly Ser
      75                  80                  85

 aag aag gtg cgg cct tgg aag tgg atg cca ttc acc aac ccg gcc cgc      400
 Lys Lys Val Arg Pro Trp Lys Trp Met Pro Phe Thr Asn Pro Ala Arg
  90                  95                 100                 105

 aag gac gga gca atg ttc ttc cac tgg cga cgt gca gcg gag gag ggc      448
 Lys Asp Gly Ala Met Phe Phe His Trp Arg Arg Ala Ala Glu Glu Gly
                 110                 115                 120

 aag gac tac ccc ttt gcc agg ttc aat aag act gtg cag gtg cct gtg      496
 Lys Asp Tyr Pro Phe Ala Arg Phe Asn Lys Thr Val Gln Val Pro Val
             125                 130                 135

 tac tcg gag cag gag tac cag ctt tat ctc cac gat gat gct tgg act      544
 Tyr Ser Glu Gln Glu Tyr Gln Leu Tyr Leu His Asp Asp Ala Trp Thr
         140                 145                 150

 aag gca gaa act gac cac ctc ttt gac ctc agc cgc cgc ttt gac ctg      592
 Lys Ala Glu Thr Asp His Leu Phe Asp Leu Ser Arg Arg Phe Asp Leu
     155                 160                 165

 cgt ttt gtt gtt atc cat gac cgg tat gac cac cag cag ttc aag aag      640
 Arg Phe Val Val Ile His Asp Arg Tyr Asp His Gln Gln Phe Lys Lys
 170                 175                 180                 185

 cgt tct gtg gaa gac ctg aag gag cgg tac tac cac atc tgt gct aag      688
 Arg Ser Val Glu Asp Leu Lys Glu Arg Tyr Tyr His Ile Cys Ala Lys
                 190                 195                 200

 ctt gcc aac gtg cgg gct gtg cca ggc aca gac ctt aag ata cca gta      736
 Leu Ala Asn Val Arg Ala Val Pro Gly Thr Asp Leu Lys Ile Pro Val
             205                 210                 215

 ttt gat gct ggg cac gaa cga cgg cgg aag gaa cag ctt gag cgt ctc      784
 Phe Asp Ala Gly His Glu Arg Arg Arg Lys Glu Gln Leu Glu Arg Leu
         220                 225                 230

 tac aac cgg acc cca gag cag gtg gca gag gag gag tac ctg cta cag      832
 Tyr Asn Arg Thr Pro Glu Gln Val Ala Glu Glu Glu Tyr Leu Leu Gln
     235                 240                 245

 gag ctg cgc aag att gag gcc cgg aag aag gag cgg gag aaa cgc agc      880
 Glu Leu Arg Lys Ile Glu Ala Arg Lys Lys Glu Arg Glu Lys Arg Ser
 250                 255                 260                 265

 cag gac ctg cag aag ctg atc aca gcg gca gac acc act gca gag cag      928
 Gln Asp Leu Gln Lys Leu Ile Thr Ala Ala Asp Thr Thr Ala Glu Gln
                 270                 275                 280

 cgg cgc acg gaa cgc aag gcc ccc aaa aag aag cta ccc cag aaa aag      976
 Arg Arg Thr Glu Arg Lys Ala Pro Lys Lys Lys Leu Pro Gln Lys Lys
             285                 290                 295

 gag gct gag aag ccg gct gtt cct gag act gca ggc atc aag ttt cca     1024
 Glu Ala Glu Lys Pro Ala Val Pro Glu Thr Ala Gly Ile Lys Phe Pro
         300                 305                 310

 gac ttc aag tct gca ggt gtc acg ctg cgg agc caa cgg atg aag ctg     1072
 Asp Phe Lys Ser Ala Gly Val Thr Leu Arg Ser Gln Arg Met Lys Leu
     315                 320                 325

 cca agc tct gtg gga cag aag aag atc aag gcc ctg gaa cag atg ctg     1120
 Pro Ser Ser Val Gly Gln Lys Lys Ile Lys Ala Leu Glu Gln Met Leu
 330                 335                 340                 345

 ctg gag ctt ggt gtg gag ctg agc ccg aca cct acg gag gag ctg gtg     1168
 Leu Glu Leu Gly Val Glu Leu Ser Pro Thr Pro Thr Glu Glu Leu Val
                 350                 355                 360

 cac atg ttc aat gag ctg cga agc gac ctg gtg ctg ctc tac gag ctc     1216
 His Met Phe Asn Glu Leu Arg Ser Asp Leu Val Leu Leu Tyr Glu Leu
             365                 370                 375

 aag cag gcc tgt gcc aac tgc gag tat gag ctg cag atg ctg cgg cac     1264
 Lys Gln Ala Cys Ala Asn Cys Glu Tyr Glu Leu Gln Met Leu Arg His
         380                 385                 390

 cgt cat gag gca ctg gcc cgg gct ggt gtg cta ggg ggc cct gcc aca     1312
 Arg His Glu Ala Leu Ala Arg Ala Gly Val Leu Gly Gly Pro Ala Thr
     395                 400                 405

 cca gca tca ggc cca ggc ccg gcc tct gct gag ccg gca gtg act gaa     1360
 Pro Ala Ser Gly Pro Gly Pro Ala Ser Ala Glu Pro Ala Val Thr Glu
 410                 415                 420                 425

 ccc gga ctt ggt cct gac ccc aag gac acc atc att gat gtg gtg ggc     1408
 Pro Gly Leu Gly Pro Asp Pro Lys Asp Thr Ile Ile Asp Val Val Gly
                 430                 435                 440

 gca ccc ctc acg ccc aat tcg aga aag cga cgg gag tcg gcc tcc agc     1456
 Ala Pro Leu Thr Pro Asn Ser Arg Lys Arg Arg Glu Ser Ala Ser Ser
             445                 450                 455

 tca tct tcc gtg aag aaa gcc aag aag ccg t gagaggcccc acggggtgtg     1507
 Ser Ser Ser Val Lys Lys Ala Lys Lys Pro 
         460                 465

 ggcgacgctg ttatgtaaat agagctgctg agttggaaaa aaaaaaaa                1555




      <210> 121
      <211> 1654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (86)..(1585)

      <400> 121
 ttggcacgag ggtagtgggg gctgcagctg ccggacccag gcactgaccc ttgacctccg     60

 gtggctcccc catctctcag gcgcg  atg gct acg ggc gcg gat gta cgg gac     112
                              Met Ala Thr Gly Ala Asp Val Arg Asp
                                1               5

 att cta gaa ctc ggg ggt cca gaa ggg gat gca gcc tct ggg acc atc      160
 Ile Leu Glu Leu Gly Gly Pro Glu Gly Asp Ala Ala Ser Gly Thr Ile
  10                  15                  20                  25

 agc aag aag gac att atc aac ccg gac aag aaa aaa tcc aag aag tcc      208
 Ser Lys Lys Asp Ile Ile Asn Pro Asp Lys Lys Lys Ser Lys Lys Ser
                  30                  35                  40

 tct gag aca ctg act ttc aag agg ccc gag ggc atg cac cgg gaa gtc      256
 Ser Glu Thr Leu Thr Phe Lys Arg Pro Glu Gly Met His Arg Glu Val
              45                  50                  55

 tat gcc ttg ctc tac tct gac aag aag gat gca ccc cca ctg cta ccc      304
 Tyr Ala Leu Leu Tyr Ser Asp Lys Lys Asp Ala Pro Pro Leu Leu Pro
          60                  65                  70

 agt gac act ggc cag gga tac cgt aca gtg aag gcc aag ttg ggc tcc      352
 Ser Asp Thr Gly Gln Gly Tyr Arg Thr Val Lys Ala Lys Leu Gly Ser
      75                  80                  85

 aag aag gtg cgg cct tgg aag tgg atg cca ttc acc aac ccg gcc cgc      400
 Lys Lys Val Arg Pro Trp Lys Trp Met Pro Phe Thr Asn Pro Ala Arg
  90                  95                 100                 105

 aag gac gga gca atg ttc ttc cac tgg cga cgt gca gcg gag gag ggc      448
 Lys Asp Gly Ala Met Phe Phe His Trp Arg Arg Ala Ala Glu Glu Gly
                 110                 115                 120

 aag gac tac ccc ttt gcc agg ttc aat aag act gtg cag gtg cct gtg      496
 Lys Asp Tyr Pro Phe Ala Arg Phe Asn Lys Thr Val Gln Val Pro Val
             125                 130                 135

 tac tcg gag cag gag tac cag ctt tat ctc cac gat gat gct tgg act      544
 Tyr Ser Glu Gln Glu Tyr Gln Leu Tyr Leu His Asp Asp Ala Trp Thr
         140                 145                 150

 aag gca gaa act gac cac ctc ttt gac ctc agc cgc cgc ttt gac ctg      592
 Lys Ala Glu Thr Asp His Leu Phe Asp Leu Ser Arg Arg Phe Asp Leu
     155                 160                 165

 cgt ttt gtt gtt atc cat gac cgg tat gac cac cag cag ttc aag aag      640
 Arg Phe Val Val Ile His Asp Arg Tyr Asp His Gln Gln Phe Lys Lys
 170                 175                 180                 185

 cgt tct gtg gaa gac ctg aag gag cgg tac tac cac atc tgt gct aag      688
 Arg Ser Val Glu Asp Leu Lys Glu Arg Tyr Tyr His Ile Cys Ala Lys
                 190                 195                 200

 ctt gcc aac gtg cgg gct gtg cca ggc aca gac ctt gct ggg cac gaa      736
 Leu Ala Asn Val Arg Ala Val Pro Gly Thr Asp Leu Ala Gly His Glu
             205                 210                 215

 cga cgg cgg aag gaa cag ctt gag cgt ctc tac aac cgg acc cca gag      784
 Arg Arg Arg Lys Glu Gln Leu Glu Arg Leu Tyr Asn Arg Thr Pro Glu
         220                 225                 230

 cag gtg gca gag gag gag tac ctg cta cag gag ctg cgc aag ata cca      832
 Gln Val Ala Glu Glu Glu Tyr Leu Leu Gln Glu Leu Arg Lys Ile Pro
     235                 240                 245

 gta ttt gat gct ggg cac gaa cga cgg cgg aag gaa cag ctt gag cgt      880
 Val Phe Asp Ala Gly His Glu Arg Arg Arg Lys Glu Gln Leu Glu Arg
 250                 255                 260                 265

 ctc tac aac cgg acc cca gag cag gtg gca gag gag gag tac ctg cta      928
 Leu Tyr Asn Arg Thr Pro Glu Gln Val Ala Glu Glu Glu Tyr Leu Leu
                 270                 275                 280

 cag gag ctg cgc aag att gag gcc cgg aag aag gag cgg gag aaa cgc      976
 Gln Glu Leu Arg Lys Ile Glu Ala Arg Lys Lys Glu Arg Glu Lys Arg
             285                 290                 295

 agc cag gac ctg cag aag ctg atc aca gcg gca gac acc act gca gag     1024
 Ser Gln Asp Leu Gln Lys Leu Ile Thr Ala Ala Asp Thr Thr Ala Glu
         300                 305                 310

 cag cgg cgc acg gaa cgc aag gcc ccc aaa aag aag cta ccc cag aaa     1072
 Gln Arg Arg Thr Glu Arg Lys Ala Pro Lys Lys Lys Leu Pro Gln Lys
     315                 320                 325

 aag gag gct gag aag ccg gct gtt cct gag act gca ggc atc aag ttt     1120
 Lys Glu Ala Glu Lys Pro Ala Val Pro Glu Thr Ala Gly Ile Lys Phe
 330                 335                 340                 345

 cca gac ttc aag tct gca ggt gtc acg ctg cgg agc caa cgg atg aag     1168
 Pro Asp Phe Lys Ser Ala Gly Val Thr Leu Arg Ser Gln Arg Met Lys
                 350                 355                 360

 ctg cca agc tct gtg gga cag aag aag atc aag gcc ctg gaa cag atg     1216
 Leu Pro Ser Ser Val Gly Gln Lys Lys Ile Lys Ala Leu Glu Gln Met
             365                 370                 375

 ctg ctg gag ctt ggt gtg gag ctg agc ccg aca cct acg gag gag ctg     1264
 Leu Leu Glu Leu Gly Val Glu Leu Ser Pro Thr Pro Thr Glu Glu Leu
         380                 385                 390

 gtg cac atg ttc aat gag ctg cga agc gac ctg gtg ctg ctc tac gag     1312
 Val His Met Phe Asn Glu Leu Arg Ser Asp Leu Val Leu Leu Tyr Glu
     395                 400                 405

 ctc aag cag gcc tgt gcc aac tgc gag tat gag ctg cag atg ctg cgg     1360
 Leu Lys Gln Ala Cys Ala Asn Cys Glu Tyr Glu Leu Gln Met Leu Arg
 410                 415                 420                 425

 cac cgt cat gag gca ctg gcc cgg gct ggt gtg cta ggg ggc cct gcc     1408
 His Arg His Glu Ala Leu Ala Arg Ala Gly Val Leu Gly Gly Pro Ala
                 430                 435                 440

 aca cca gca tca ggc cca ggc ccg gcc tct gct gag ccg gca gtg act     1456
 Thr Pro Ala Ser Gly Pro Gly Pro Ala Ser Ala Glu Pro Ala Val Thr
             445                 450                 455

 gaa ccc gga ctt ggt cct gac ccc aag gac acc atc att gat gtg gtg     1504
 Glu Pro Gly Leu Gly Pro Asp Pro Lys Asp Thr Ile Ile Asp Val Val
         460                 465                 470

 ggc gca ccc ctc acg ccc aat tcg aga aag cga cgg gag tcg gcc tcc     1552
 Gly Ala Pro Leu Thr Pro Asn Ser Arg Lys Arg Arg Glu Ser Ala Ser
     475                 480                 485

 agc tca tct tcc gtg aag aaa gcc aag aag ccg tgagaggc cccacggggt     1603
 Ser Ser Ser Ser Val Lys Lys Ala Lys Lys Pro 
 490                 495                 500

 gtgggcgacg ctgttatgta aatagagctg ctgagttgga aaaaaaaaaa a            1654




      <210> 122
      <211> 1284
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (321)..(1067)

      <400> 122
 gcacgaggtc agacaagcac tggacgtggc ggccattttg ttttggacac cgagcaggag     60

 ctggcggccg ctgcagacga aaggcaggaa agggcaggcc gggtgagcag acggatcggc    120

 cgactagaca gccaaccagc aacaacgaac tgagctcgca tactaccgct tacgcatcta    180

 accaaccgcc catctagcta acccgagccc ctccaccgtc aactcaggtt cggccggtcc    240

 ccggcccgcc tgccggagcc gtggtggcag ccccgggagg agcactggcg tctgtttcct    300

 tcgattctcg ggattcgaag    atg gct gca cag tca gcg ccg aaa gtt gtg     350
                          Met Ala Ala Gln Ser Ala Pro Lys Val Val
                            1               5                  10

 cta aaa agc acc acc aag atg tct cta aat gag cgc ttt act aat atg      398
 Leu Lys Ser Thr Thr Lys Met Ser Leu Asn Glu Arg Phe Thr Asn Met
                  15                  20                  25

 ctg aag aac aaa cag ccg acg cca gtg aat att cgg gct tcg atg cag      446
 Leu Lys Asn Lys Gln Pro Thr Pro Val Asn Ile Arg Ala Ser Met Gln
              30                  35                  40

 caa caa cag cag cta gcc agt gcc aga aac aga aga ctg gcc cag cag      494
 Gln Gln Gln Gln Leu Ala Ser Ala Arg Asn Arg Arg Leu Ala Gln Gln
          45                  50                  55

 atg gag aat aga ccc tct gtc cag gca gca tta aaa ctt aag cag aag      542
 Met Glu Asn Arg Pro Ser Val Gln Ala Ala Leu Lys Leu Lys Gln Lys
      60                  65                  70

 agc tta aag cag cgc ctg ggt aag agt aac atc cag gca cgg tta ggc      590
 Ser Leu Lys Gln Arg Leu Gly Lys Ser Asn Ile Gln Ala Arg Leu Gly
  75                  80                  85                  90

 cga ccc ata ggg gcc ctg gcc agg gga gca atc gga gga cga ggc cta      638
 Arg Pro Ile Gly Ala Leu Ala Arg Gly Ala Ile Gly Gly Arg Gly Leu
                  95                 100                 105

 ccc ata atc cag aga ggc ttg ccc aga gga gga cta cgt ggg gga cgt      686
 Pro Ile Ile Gln Arg Gly Leu Pro Arg Gly Gly Leu Arg Gly Gly Arg
             110                 115                 120

 gcc acc aga acc cta ctt agg ggc ggg atg tca ctc cga ggt caa aac      734
 Ala Thr Arg Thr Leu Leu Arg Gly Gly Met Ser Leu Arg Gly Gln Asn
         125                 130                 135

 ctg ctc cga ggt gga cga gcc gta gct ccc cga atg ggc tta aga aga      782
 Leu Leu Arg Gly Gly Arg Ala Val Ala Pro Arg Met Gly Leu Arg Arg
     140                 145                 150

 ggt ggt gtt cga ggt cgt gga ggt cct ggg aga ggg ggc cta ggg cgt      830
 Gly Gly Val Arg Gly Arg Gly Gly Pro Gly Arg Gly Gly Leu Gly Arg
 155                 160                 165                 170

 gga gct atg ggt cgt ggc gga atc ggt ggt aga ggt cgg ggt atg ata      878
 Gly Ala Met Gly Arg Gly Gly Ile Gly Gly Arg Gly Arg Gly Met Ile
                 175                 180                 185

 ggt cgg gga aga ggg ggc ttt gga ggc cga ggc cga ggc cgt gga cga      926
 Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Arg Gly Arg
             190                 195                 200

 ggg aga ggt gcc ctt gct cgc cct gta ttg acc aag gag cag ctg gac      974
 Gly Arg Gly Ala Leu Ala Arg Pro Val Leu Thr Lys Glu Gln Leu Asp
         205                 210                 215

 aac caa ttg gat gca tat atg tcg aaa aca aaa gga cac ctg gat gct     1022
 Asn Gln Leu Asp Ala Tyr Met Ser Lys Thr Lys Gly His Leu Asp Ala
     220                 225                 230

 gag ttg gat gcc tac atg gcg cag aca gat ccc gaa acc aat gat tga     1070
 Glu Leu Asp Ala Tyr Met Ala Gln Thr Asp Pro Glu Thr Asn Asp 
 235                 240                 245

 agcctgccca tcctcccatg agagactctt gttagtcaac acatctgtaa ataaccttga   1130

 gataacagat gagaagaaat ctgattgatg ctggatggac ctatcacaat aggctgtgga   1190

 cttacttgcc accagcttgt gcatttagtg tgttcctttt actttttgat actgtgttgt   1250

 atgaaaccct tttgtccttt gaaaaaaaaa aaaa                               1284




      <210> 123
      <211> 1934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (338)..(1162)

      <400> 123
 ggatgggatg aggggcgagg cttgggaggc gaccaatcga agagtagaat gctgcgtccc     60

 tcactggagc ttcagcggtc ggaacgcggg ggtggggcat gtcctgccga aatttgcgtc    120

 cttagagcgg aagtacggcc ggaagcccgc catagagttt agtggccaga gcgactcttc    180

 agggaggtgg caggaaaggc ttggaacagc tgccggaggt gacggagcgg cggccccgcc    240

 cggtgcgctg gaggtcgaag cttccaggta gcggcccgca gagcctgacc caggctctgg    300

 acatcctgag cccaagtccc ccacactcag tgcagtg atg agt gcg gaa gtg aag     355
                                          Met Ser Ala Glu Val Lys
                                            1               5

 gtg aca ggg cag aac cag gag caa ttt ctg ctc cta gcc aag tcg gcc      403
 Val Thr Gly Gln Asn Gln Glu Gln Phe Leu Leu Leu Ala Lys Ser Ala
              10                  15                  20

 aag ggg gca gcg ctg gcc aca ctc atc cat cag gtg ctg gag gcc cct      451
 Lys Gly Ala Ala Leu Ala Thr Leu Ile His Gln Val Leu Glu Ala Pro
          25                  30                  35

 ggt gtc tac gtg ttt gga gaa ctg ctg gac atg ccc aat gtt aga gag      499
 Gly Val Tyr Val Phe Gly Glu Leu Leu Asp Met Pro Asn Val Arg Glu
      40                  45                  50

 ctg gct gag agt gac ttt gcc tct acc ttc cgg ctg ctc aca gtg ttt      547
 Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe Arg Leu Leu Thr Val Phe
  55                  60                  65                  70

 gct tat ggg aca tac gct gac tac tta gct gaa gcc cgg aat ctt cct      595
 Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala Glu Ala Arg Asn Leu Pro
                  75                  80                  85

 cca cta aca gag gct cag aag aat aag ctt cga cac ctc tca gtt gtc      643
 Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu Arg His Leu Ser Val Val
              90                  95                 100

 acc ctg gct gct aaa gta aag tgt atc cca tat gca gtg ttg ctg gag      691
 Thr Leu Ala Ala Lys Val Lys Cys Ile Pro Tyr Ala Val Leu Leu Glu
         105                 110                 115

 gct ctt gcc ctg cgt aat gtg cgg cag ctg gaa gac ctt gtg att gag      739
 Ala Leu Ala Leu Arg Asn Val Arg Gln Leu Glu Asp Leu Val Ile Glu
     120                 125                 130

 gct gtg tat gct gac gtg ctt cgt ggc tcc ctg gac cag cgc aac cag      787
 Ala Val Tyr Ala Asp Val Leu Arg Gly Ser Leu Asp Gln Arg Asn Gln
 135                 140                 145                 150

 cgg ctc gag gtt gac tac agc atc ggg cgg gac atc cag cgc cag gac      835
 Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg Asp Ile Gln Arg Gln Asp
                 155                 160                 165

 ctc agt gcc att gcc cga acc ctg cag gaa tgg tgt gtg ggc tgt gag      883
 Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu Trp Cys Val Gly Cys Glu
             170                 175                 180

 gtc gtg ctg tca ggc att gag gag cag gtg agc cgt gcc aac caa cac      931
 Val Val Leu Ser Gly Ile Glu Glu Gln Val Ser Arg Ala Asn Gln His
         185                 190                 195

 aag gag cag cag ctg ggc ctg aag cag cag att gag agt gag gtt gcc      979
 Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln Ile Glu Ser Glu Val Ala
     200                 205                 210

 aac ctt aaa aaa acc att aaa gtt acg acg gca gca gca gcc gca gcc     1027
 Asn Leu Lys Lys Thr Ile Lys Val Thr Thr Ala Ala Ala Ala Ala Ala
 215                 220                 225                 230

 aca tct cag gac cct gag caa cac ctg act gag ctg agg gaa cca gct     1075
 Thr Ser Gln Asp Pro Glu Gln His Leu Thr Glu Leu Arg Glu Pro Ala
                 235                 240                 245

 cct ggc acc aac cag cgc cag ccc agc aag aaa gcc tca aag ggc aag     1123
 Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys Lys Ala Ser Lys Gly Lys
             250                 255                 260

 ggg ctc cga ggg agc gcc aag att tgg tcc aag tcg aat tgaaagaact      1172
 Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser Lys Ser Asn 
         265                 270                 275

 gtcgtttcct ccctggggat gtggggtccc agctgcctgc ctgcctctta ggagtcctca   1232

 gagagccttc tgtgcccctg gccagctgat aatcctaggt tcatgaccct tcacctcccc   1292

 taaccccaaa catagatcac accttctcta gggaggagtc aaatgtaggt catgtttttg   1352

 ttggtacttt ctgttttttg tgacttcatg tgttccattg ctccccgctg ccatgctctc   1412

 tcccttgttt ccttaagagc tcagcatctg tccctgttca ttacatgtca ttgagtaggt   1472

 gggtagccct gatgggggtc gctctgtctg gagcataacc cacaggcgtt ttttctgcca   1532

 ccccatccct gcatgcctga tccccagttc ctatacccta cccctgacct attgagcagc   1592

 ctctgaagag ccatagggcc cccaccttta ctcacaccct gagaattctg ggagccagtc   1652

 tgccatgcca ggagtcactg gacatgttca tcctagaatc ctgtcacact acagtcattt   1712

 cttttcctct ctctggccct tgggtcctgg gaatgctgct gcttcaaccc cagagcctaa   1772

 gaatggcagc cggtgtctaa acaggtgaag agatgaatcc ttctttgggc ctggcactct   1832

 cggggaagct tgatggcaat cctggaaagg gtttaaagcc cctttggtga ggtttggggg   1892

 ggaagcgaag agggaggttg tggtgagttg tattattttt tt                      1934




      <210> 124
      <211> 692
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (74)..(442)

      <400> 124
 gcggtggaat tcgcgggacc caaccgcggc gaccggacgt gcactcctcc agtagcggct     60

 gcacgtcgtg cca   atg gcc cgc tat gag gag gtg agc gtg tcc ggc ttc     109
                  Met Ala Arg Tyr Glu Glu Val Ser Val Ser Gly Phe
                    1               5                  10

 gag gag ttc cac cgg gcc gtg gaa cag cac aat ggc aag acc att ttc      157
 Glu Glu Phe His Arg Ala Val Glu Gln His Asn Gly Lys Thr Ile Phe
          15                  20                  25

 gcc tac ttt acg ggt tct aag gac gcc ggg ggg aaa agc tgg tgc ccc      205
 Ala Tyr Phe Thr Gly Ser Lys Asp Ala Gly Gly Lys Ser Trp Cys Pro
      30                  35                  40

 gac tgc gtg cag gct gaa cca gtc gta cga gag ggg ctg aag cac att      253
 Asp Cys Val Gln Ala Glu Pro Val Val Arg Glu Gly Leu Lys His Ile
  45                  50                  55                  60

 agt gaa gga tgt gtg ttc atc tac tgc caa gta gga gaa aag cct tat      301
 Ser Glu Gly Cys Val Phe Ile Tyr Cys Gln Val Gly Glu Lys Pro Tyr
                  65                  70                  75

 tgg aaa gat cca aat aat gac ttc aga aaa aac ttg aaa gta aca gca      349
 Trp Lys Asp Pro Asn Asn Asp Phe Arg Lys Asn Leu Lys Val Thr Ala
              80                  85                  90

 gtg cct aca cta ctt aag tat gga aca cct caa aaa ctg gta gaa tct      397
 Val Pro Thr Leu Leu Lys Tyr Gly Thr Pro Gln Lys Leu Val Glu Ser
          95                 100                 105

 gag tgt ctt cag gcc aac ctg gtg gaa atg ttg ttc tct gaa gat taa      445
 Glu Cys Leu Gln Ala Asn Leu Val Glu Met Leu Phe Ser Glu Asp 
     110                 115                 120

 gattttagga tggcaatcat gtcttgatgt cctgatttgt tctagtatca ataaactgta    505

 tacttgcttt gaattcatgt tagcaataaa tgatgttaaa aaaaactggc atgtgtctaa    565

 acaatagagt gctattaaaa tgcccatgaa cctttagttt gcctgtaata catggatatt    625

 tttaagatat aaagaagtct tcagaaatag cagtaaaggc tcaaaggaac gtattcttga    685

 aggtgac                                                              692




      <210> 125
      <211> 473
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (257)..(406)

      <400> 125
 ccactcagca cccatagtcc aggcatgggg acctcaacac acctgagccc cagacatcac     60

 ctttcattgt gagtagctct gagatgacac ttctgctgtt cccaattcca gcattaattg    120

 gattagatag ttattttatg aagaattttc atatgccaca atcctgacca tatcttcaag    180

 tgaacagaaa aattctatta aaaagtcaac cttctgtctc actctgttgc ccagactgga    240

 gtgtagtggt gcaatt    atg gct cac tgc agc ctc aac ctc ctg ggc tca     289
                      Met Ala His Cys Ser Leu Asn Leu Leu Gly Ser
                        1               5                  10

 agc aat cct cct gcc tca gcc tca caa gta gct ggg act aca ggt gct      337
 Ser Asn Pro Pro Ala Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Ala
              15                  20                  25

 tgt cac cac acc tca cta att ttc cca ttt gtg tta tat gtg gat tcc      385
 Cys His His Thr Ser Leu Ile Phe Pro Phe Val Leu Tyr Val Asp Ser
          30                  35                  40

 aca gga ctg act ttg aaa act tg agtatgcgtg gattttggta tacacagaaa      438
 Thr Gly Leu Thr Leu Lys Thr 
      45                  50

 tgggagagct ggaactaatc cccccatata ccaag                               473




      <210> 126
      <211> 1174
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (560)..(853)

      <400> 126
 cgaagccgcc gcctgatact ggcattttgt agatgtggtt tgactatttc tgtatgtctc     60

 catctattga tgagggtctt actcttttag tataaatagt accgttaact tccaattaac    120

 tagttttgac aacattcaaa aaagagtaat aaacttcgcc ttaattttaa taatcaacac    180

 cctcctagcc ttactactaa taattattac attttgacta ccacaactca acggctacat    240

 agaaaaatcc accccttacg agtgcggctt cgaccctata tcccccgccc gcgtcccttt    300

 ctccataaaa ttcttcttag tagctattac cttcttatta tttgatctag aaattgccct    360

 ccttttaccc ctaccatgag ccctacaaac aactaacctg ccactaatag ttatgtcatc    420

 cctcttatta atcatcatcc tagccctaag tctggcctat gagtgactac aaaaaggatt    480

 agactgaacc gaattggtat atagtttaaa caaaacgaat gatttcgact cattaaatta    540

 tgataatcat atttaccaa atg ccc ctc att tac ata aat att ata cta gca     592
                      Met Pro Leu Ile Tyr Ile Asn Ile Ile Leu Ala
                        1               5                  10

 ttt acc atc tca ctt cta gga ata cta gta tat cgc tca cac ctc ata      640
 Phe Thr Ile Ser Leu Leu Gly Ile Leu Val Tyr Arg Ser His Leu Ile
              15                  20                  25

 tcc tcc cta cta tgc cta gaa gga ata ata cta tcg ctg ttc att ata      688
 Ser Ser Leu Leu Cys Leu Glu Gly Ile Ile Leu Ser Leu Phe Ile Ile
          30                  35                  40

 gct act ctc ata acc ctc aac acc cac tcc ctc tta gcc aat att gtg      736
 Ala Thr Leu Ile Thr Leu Asn Thr His Ser Leu Leu Ala Asn Ile Val
      45                  50                  55

 cct att gcc ata cta gtc ttt gcc gcc tgc gaa gca gcg gtg ggc cta      784
 Pro Ile Ala Ile Leu Val Phe Ala Ala Cys Glu Ala Ala Val Gly Leu
  60                  65                  70                  75

 gcc cta cta gtc tca atc tcc aac aca tat ggc cta gac tac gta cat      832
 Ala Leu Leu Val Ser Ile Ser Asn Thr Tyr Gly Leu Asp Tyr Val His
                  80                  85                  90

 aac cta aac cta ctc caa tgc ta aaactaatcg tcccaacaat tatattacta      885
 Asn Leu Asn Leu Leu Gln Cys 
              95

 ccactgacat gactttccaa aaaacacata atttgaatca acacaaccac ccacagccta    945

 attattagca tcatccctct actatttttt aaccaaatca acaacaacct atttagctgt   1005

 tccccaacct tttcctccga ccccctaaca acccccctcc taatactaac tacctgactc   1065

 ctacccctca caatcatggc aagccaacgc cacttatcca gtgaaccact atcacgaaaa   1125

 aaactctacc tctctatact aatctcccta caaatctcct taattataa               1174




      <210> 127
      <211> 4105
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (112)..(1215)

      <400> 127
 cgactcccgc tcgtgccccg gagtcaccgc cgtccgcgga tccggcgcta gtagcggggc     60

 ctgccgagga agccgagtgc ccgccgccgc gccagcctca gcccgcgcag a atg tgc     117
                                                          Met Cys
                                                            1

 tcg ctg ccc cgc ggc ttc gag ccc caa gct ccc gag gac ttg gcg cag      165
 Ser Leu Pro Arg Gly Phe Glu Pro Gln Ala Pro Glu Asp Leu Ala Gln
           5                  10                  15

 cgg agt ttg gtg gag ctg cgg gaa atg ttg aag cgc cag gag aga ctt      213
 Arg Ser Leu Val Glu Leu Arg Glu Met Leu Lys Arg Gln Glu Arg Leu
      20                  25                  30

 ttg cgc aac gaa aaa ttc att tgc aaa ttg ccc gac aaa ggt aaa aag      261
 Leu Arg Asn Glu Lys Phe Ile Cys Lys Leu Pro Asp Lys Gly Lys Lys
  35                  40                  45                  50

 atc ttt gac tct ttt gcc aaa ctg aaa gct gcc att gca gaa tgt gaa      309
 Ile Phe Asp Ser Phe Ala Lys Leu Lys Ala Ala Ile Ala Glu Cys Glu
                  55                  60                  65

 gaa gtt aga aga aaa agt gaa ctg ttt aac cct gtt agt tta gac tgt      357
 Glu Val Arg Arg Lys Ser Glu Leu Phe Asn Pro Val Ser Leu Asp Cys
              70                  75                  80

 aag cta agg caa aaa gca att gca gaa gtt gat gtg ggt aca gat aag      405
 Lys Leu Arg Gln Lys Ala Ile Ala Glu Val Asp Val Gly Thr Asp Lys
          85                  90                  95

 gcc cag aat tct gac ccg ata ctt gat act tca tca cta gtt cct gga      453
 Ala Gln Asn Ser Asp Pro Ile Leu Asp Thr Ser Ser Leu Val Pro Gly
     100                 105                 110

 tgt tcc tct gta gat aac atc aag tca tct caa acc tca caa aac cag      501
 Cys Ser Ser Val Asp Asn Ile Lys Ser Ser Gln Thr Ser Gln Asn Gln
 115                 120                 125                 130

 gga ctt gga cgt cct act ctt gaa ggt gat gaa gag act tca gag gtt      549
 Gly Leu Gly Arg Pro Thr Leu Glu Gly Asp Glu Glu Thr Ser Glu Val
                 135                 140                 145

 gag tac aca gtg aat aag ggc cca gct tcc agc aat aga gac agg gta      597
 Glu Tyr Thr Val Asn Lys Gly Pro Ala Ser Ser Asn Arg Asp Arg Val
             150                 155                 160

 cca cct tca tct gaa gct agt gag cat cac ccg cgg cat cgt gtt tca      645
 Pro Pro Ser Ser Glu Ala Ser Glu His His Pro Arg His Arg Val Ser
         165                 170                 175

 agt caa gcg gaa gat act tcc agc agc ttt gac aac ctg ttt att gac      693
 Ser Gln Ala Glu Asp Thr Ser Ser Ser Phe Asp Asn Leu Phe Ile Asp
     180                 185                 190

 agg tta cag agg atc acc att gcg gac caa ggt gaa caa cag tca gaa      741
 Arg Leu Gln Arg Ile Thr Ile Ala Asp Gln Gly Glu Gln Gln Ser Glu
 195                 200                 205                 210

 gaa aac gca agt act aag aac ttg aca ggc ctt tcc agt ggg act gag      789
 Glu Asn Ala Ser Thr Lys Asn Leu Thr Gly Leu Ser Ser Gly Thr Glu
                 215                 220                 225

 aag aaa cct cat tac atg gaa gtg cta gaa atg cga gcc aaa aac cca      837
 Lys Lys Pro His Tyr Met Glu Val Leu Glu Met Arg Ala Lys Asn Pro
             230                 235                 240

 gtg ccc cag ctg cgt aaa ttt aaa acc aat gtg tta cct ttt cga caa      885
 Val Pro Gln Leu Arg Lys Phe Lys Thr Asn Val Leu Pro Phe Arg Gln
         245                 250                 255

 aat gat tca tct agt cat tgc cag aag agt ggg tct cct att tcc tca      933
 Asn Asp Ser Ser Ser His Cys Gln Lys Ser Gly Ser Pro Ile Ser Ser
     260                 265                 270

 gaa gag cgg cgg cgc agg gat aag cag cat ctt gat gac atc aca gca      981
 Glu Glu Arg Arg Arg Arg Asp Lys Gln His Leu Asp Asp Ile Thr Ala
 275                 280                 285                 290

 gct cgg ctt cta cca ctt cac cat atg ccc acg cag ctg ctc tcc ata     1029
 Ala Arg Leu Leu Pro Leu His His Met Pro Thr Gln Leu Leu Ser Ile
                 295                 300                 305

 gaa gaa tcc ttg gca ctt cag aaa cag cag aaa cag aat tat gag gag     1077
 Glu Glu Ser Leu Ala Leu Gln Lys Gln Gln Lys Gln Asn Tyr Glu Glu
             310                 315                 320

 atg caa gca aag ctc gca gcg caa aaa tta gct gaa aga ctg aat att     1125
 Met Gln Ala Lys Leu Ala Ala Gln Lys Leu Ala Glu Arg Leu Asn Ile
         325                 330                 335

 aaa atg cgg agt tat aat cca gaa ggg gag tct tca ggg aga tac cga     1173
 Lys Met Arg Ser Tyr Asn Pro Glu Gly Glu Ser Ser Gly Arg Tyr Arg
     340                 345                 350

 gaa gta agg gat gaa gat gac gat tgg tcc tct gat gaa ttc tgaagat     1222
 Glu Val Arg Asp Glu Asp Asp Asp Trp Ser Ser Asp Glu Phe 
 355                 360                 365

 aatctcctaa atcactgacg ttgagatgtc atcatcttac atcagacttt ctaactagta   1282

 tcaagatcag tgtcagatat tgttgaggga agtaatttta taaagttaca caaaggtagt   1342

 tataaaaaaa gcccagtttg tctttcagaa ggtgactttc atgtgcttga aaagtttaat   1402

 atttgaatat tgtgtttaac cacatggtat taaaattttg caatatattg tgtattggtc   1462

 tgatatttta gtatatagta gaacatactt tttttttctt taagccaaat gaaaagaggt   1522

 aactttgctt ttttcctttt tcttacctat caaatagcat ttattacatg tctttcagtg   1582

 aaatacttag ttgttccagg cacctaaaat caattaggaa gacatagttc ccttcttttt   1642

 tgggtaatga agggagcagt ctaaagaatt gtatgcatgt ttgcatgggg ttattgagac   1702

 attggatgtg aaatacctag gaagacatgt atggagaatg cttaacaaat gctcttctcc   1762

 tttttctgtc ttcccttagg aagaacgtta tctctcttct gattaggaag gacttccctt   1822

 ttgagtagat gctggaaagt ggaggttttt tttgttggtt tgtttgtttg gttttgtgtt   1882

 tttttttgag atggggtctt gctctgtcgc ccaggctgga gtgcagtggc aggatctcgg   1942

 ctcactgcaa tctaggtgga ggtcttttta aataacctca tgttacttca ggcaaatctg   2002

 gtacaggaga agcccaagct aactgagctg ggtgaaggct tgtgcatcac ctggcttgag   2062

 ttccttgctg tcacagatga taggttcatg tacacaacat taatgtttga taaggaaagc   2122

 attttttttt tgttaaaatt gaattgtcag tactttactt ttttcccccc aaataggtat   2182

 atatagactg cagaagcttc agtcccatat ataaacgttc atgtcatttt agaggattat   2242

 atggttgtct ccagagaaat taacttacat tatcaaaaaa ttctttgtct aatatattgg   2302

 agtctttaaa agtgttgaag aataaaatat taattagaac aacttcaaat gctaaggtga   2362

 tgttttaccg ggacttaatt aaatacaact ttttcctttc gaaaaagact gttcacattt   2422

 gcttccaggt gtaattattg ctttcattcc ttacccccct caagcaaatg tgaaaagtat   2482

 actgacctaa gattctcatt agttttagtt cttaaaacga atagtaaatg atttcacagc   2542

 gtaaaatttg atgttatttc tggaagctgg atgatatgga agagttcatg tgcctggaca   2602

 cacagttccc tgtaatcctg ccatctaggg agataaactc tgttaacatt ttgatgttgt   2662

 gtttttgctt atttttctat gcatagttat gcatttatat tctcaaaaat gaaatcataa   2722

 tgtacattgc tttgtagtct gctctatata ttgtcaatat gttcccatat taaatatttt   2782

 gctttttaga cagctgtagg atattttatt tcatgggtat accataactt taagatttat   2842

 ttcctattca gcaatttgat tatgtattat aatgtaatct gtaaatagtg atatgattaa   2902

 catcttaatc acatccatag aaaatgactt atttccagaa gataccgctc taaaaatgaa   2962

 attgttaggt gaaagtgttt ttgagaattt ttatatatat tactcactgc agagatcatg   3022

 ttcatttaca ttcccattag caatatatcc aatgctcaga attgaaaatt actacttaaa   3082

 atctttgcaa attgaataat tacagaaaag ggctacattt aaaatttgta tttgtttttc   3142

 ttacttagtg aaggttgtgt tttttttcat attcattggc catgctatat tcattctttt   3202

 gagaattgct cattcatatt ttttctgttg cttgcttgga gaatttgctc tttttttggc   3262

 atataagttc ttaagaatgt ccgtcctttg tcatatattg taactttttt taaccttatt   3322

 tgtcatttaa catagtttgt ggtatttcag tatagaagtt gttttcttta ggagtctacc   3382

 tttgtgtatg tgcttgaaag tatttttgta atccaagaat ggataaatgt ccttattttc   3442

 ttctagtatt ttcttatttc acttttacac ctatctttaa aaggaattta aattttgttt   3502

 atatacatta actaaatcag tacaagtttg gggtgaaaag gaaattttta atccatctca   3562

 aatgtatttg gttatattat ataaggtagg gatttgattt tatttcgaag aatttaccaa   3622

 ttggttcagt atgtgaaacc accatttccc ctctgattag taatgctatt tttatagaat   3682

 attaaattct tatgtgtctt ttgtgtctta ggccaatttc tgggccttct gggttttttc   3742

 tacactgtca ataattatcg ctttaattgg tgttaatatt tggtagtaca caggttctcc   3802

 cttgttcttt taaattttgt gaaatataac ttacaaataa gtacttaaaa cagagcttaa   3862

 tgggtaaagc aacagctgtg taatcacaaa ctagatgcag aggaggtctt gccagcactc   3922

 caaaatctct gtgtgtcccc tcttgacact cactgtttcc cccagagcta actatcctga   3982

 cgtatggtaa ttctccctct gtccttttaa gaattatttt accagttatg tgtataacaa   4042

 tatggtttac attttgctca cttttgactt atataaaaat agaataatac taaaaaaaaa   4102

 aaa                                                                 4105




      <210> 128
      <211> 2495
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (525)..(2135)

      <400> 128
 tcacgttgtc ttcggtagtc ctgagcgccg ggcctgaagg actcctaggc gtggagcaga     60

 gcgacaaaac agaccagttt ctagtgacag acagcggcag gacagtcatc ctctataagg    120

 tttctgatca gaaacccttg gggagctggt cagtgaaaca aggtcaaatt ataacatgtc    180

 cagctgtgtg caactttcaa actggagagt atgttgttgt acacgataat aaggttttaa    240

 gaatatggaa taatgaagat gtaaacctgg ataaagtatt taaagctaca ttgtcagcag    300

 aagtatatag gatactttca gtgcaaggga cagaaccctt ggtgctcttc aaggaaggtg    360

 ctgttcgtgg tttagaggcc ttgcttgcag acccccagca gaaaattgaa actgttatct    420

 ctgatgaaga agtgattaaa tggacaaagt ttttcgtagt attcagacat cctgttttaa    480

 tttttattac tgaaaaacat ggaaattact ttgcttacgt gcaa atg ttt aac tca     536
                                                  Met Phe Asn Ser
                                                    1

 cgt atc tta acc aaa tat aca ctc tta ctt gga caa gac gaa aac tct      584
 Arg Ile Leu Thr Lys Tyr Thr Leu Leu Leu Gly Gln Asp Glu Asn Ser
   5                  10                  15                  20

 gtt ata aag agt ttt act gca tct gta gat cgg aaa ttc atc tct ttg      632
 Val Ile Lys Ser Phe Thr Ala Ser Val Asp Arg Lys Phe Ile Ser Leu
                  25                  30                  35

 atg tca tta agc tct gat ggt tgt ata tat gaa acc ttg ata cca ata      680
 Met Ser Leu Ser Ser Asp Gly Cys Ile Tyr Glu Thr Leu Ile Pro Ile
              40                  45                  50

 cgt cca gct gac cca gaa aaa aat cag agc tta gtt aaa tca ctg ctg      728
 Arg Pro Ala Asp Pro Glu Lys Asn Gln Ser Leu Val Lys Ser Leu Leu
          55                  60                  65

 ctc aag gct gtt gta tct ggt aac gct cga aat gga gtt gca ctc act      776
 Leu Lys Ala Val Val Ser Gly Asn Ala Arg Asn Gly Val Ala Leu Thr
      70                  75                  80

 gcc ctg gat cag gat cac gtc gca gtc cta gga agt cca cta gca gct      824
 Ala Leu Asp Gln Asp His Val Ala Val Leu Gly Ser Pro Leu Ala Ala
  85                  90                  95                 100

 tct aag gaa tgc ctc tct gta tgg aac ata aaa ttt caa aca cta cag      872
 Ser Lys Glu Cys Leu Ser Val Trp Asn Ile Lys Phe Gln Thr Leu Gln
                 105                 110                 115

 act tca aaa gag tta cca caa ggg acc agt ggt caa ctc tgg tat tat      920
 Thr Ser Lys Glu Leu Pro Gln Gly Thr Ser Gly Gln Leu Trp Tyr Tyr
             120                 125                 130

 gga gaa cat ttg ttt atg cta cat gga aaa tct cta act gtg att cca      968
 Gly Glu His Leu Phe Met Leu His Gly Lys Ser Leu Thr Val Ile Pro
         135                 140                 145

 tac aag tgt gaa gtg tca tca tta gca ggt gct ctt gga aaa ctc aag     1016
 Tyr Lys Cys Glu Val Ser Ser Leu Ala Gly Ala Leu Gly Lys Leu Lys
     150                 155                 160

 cat agt caa gat cca gga act cat gtc gtg tcc cat ttt gta aac tgg     1064
 His Ser Gln Asp Pro Gly Thr His Val Val Ser His Phe Val Asn Trp
 165                 170                 175                 180

 gag aca cct caa gga tgt gga ctt ggg ttc cag aac tca gag cag tca     1112
 Glu Thr Pro Gln Gly Cys Gly Leu Gly Phe Gln Asn Ser Glu Gln Ser
                 185                 190                 195

 aga aga att tta agg aga cga aaa att gaa gtg agt tta cag cca gag     1160
 Arg Arg Ile Leu Arg Arg Arg Lys Ile Glu Val Ser Leu Gln Pro Glu
             200                 205                 210

 gtt cca cca tcc aaa caa ctt ttg tca acc ata atg aaa gat tca gaa     1208
 Val Pro Pro Ser Lys Gln Leu Leu Ser Thr Ile Met Lys Asp Ser Glu
         215                 220                 225

 aaa cac att gaa gta gaa gta cgg aaa ttt ttg gct ctg aag cag aca     1256
 Lys His Ile Glu Val Glu Val Arg Lys Phe Leu Ala Leu Lys Gln Thr
     230                 235                 240

 cct gac ttt cat act gtc att ggg gac aca gta aca gga ctt ctg gaa     1304
 Pro Asp Phe His Thr Val Ile Gly Asp Thr Val Thr Gly Leu Leu Glu
 245                 250                 255                 260

 agg tgt aaa gca gaa cca tca ttt tat ccc cgg aac tgt ctg atg cag     1352
 Arg Cys Lys Ala Glu Pro Ser Phe Tyr Pro Arg Asn Cys Leu Met Gln
                 265                 270                 275

 ctt atc caa acg cat gtg ctt tct tac agt ttg tgc ccc gac tta atg     1400
 Leu Ile Gln Thr His Val Leu Ser Tyr Ser Leu Cys Pro Asp Leu Met
             280                 285                 290

 gag att gcc tta aaa aag aaa gat gta cag ttg tta caa ctc tgt cta     1448
 Glu Ile Ala Leu Lys Lys Lys Asp Val Gln Leu Leu Gln Leu Cys Leu
         295                 300                 305

 cag cag ttc cct gac att cct gaa tca gtc acc tgt gct tgc tta aaa     1496
 Gln Gln Phe Pro Asp Ile Pro Glu Ser Val Thr Cys Ala Cys Leu Lys
     310                 315                 320

 att ttc ttg agc att ggt gat gac agt ctt caa gaa aca gat gtt aat     1544
 Ile Phe Leu Ser Ile Gly Asp Asp Ser Leu Gln Glu Thr Asp Val Asn
 325                 330                 335                 340

 atg gag tca gtt ttt gac tat agt ata aat tct gta cat gat gag aaa     1592
 Met Glu Ser Val Phe Asp Tyr Ser Ile Asn Ser Val His Asp Glu Lys
                 345                 350                 355

 atg gaa gag caa act gaa att ctt caa aat ggc ttc aat cct gaa gaa     1640
 Met Glu Glu Gln Thr Glu Ile Leu Gln Asn Gly Phe Asn Pro Glu Glu
             360                 365                 370

 gat aaa tgc aat aac tgt gat caa gag tta aat aaa aag ccc cag gac     1688
 Asp Lys Cys Asn Asn Cys Asp Gln Glu Leu Asn Lys Lys Pro Gln Asp
         375                 380                 385

 gaa aca aag gag agc act tca tgc cct gtg gta caa aaa aga gca gct     1736
 Glu Thr Lys Glu Ser Thr Ser Cys Pro Val Val Gln Lys Arg Ala Ala
     390                 395                 400

 cta ctt aat gca att ctt cat tca gca tat agc gag aca ttt ctt ctg     1784
 Leu Leu Asn Ala Ile Leu His Ser Ala Tyr Ser Glu Thr Phe Leu Leu
 405                 410                 415                 420

 cct cat ttg aaa gac atc cca gca cag cat atc acg ctg ttt ctt aag     1832
 Pro His Leu Lys Asp Ile Pro Ala Gln His Ile Thr Leu Phe Leu Lys
                 425                 430                 435

 tat ttg tat ttc ctg tac ctg aag tgt agc gaa aat gct act atg act     1880
 Tyr Leu Tyr Phe Leu Tyr Leu Lys Cys Ser Glu Asn Ala Thr Met Thr
             440                 445                 450

 ctt cct gga ata cac cca cct acc ttg aac cag att atg gat tgg ata     1928
 Leu Pro Gly Ile His Pro Pro Thr Leu Asn Gln Ile Met Asp Trp Ile
         455                 460                 465

 tgt cta ctt ctg gat gca aat ttt act gtt gtt gta atg atg cca gaa     1976
 Cys Leu Leu Leu Asp Ala Asn Phe Thr Val Val Val Met Met Pro Glu
     470                 475                 480

 gca aag agg cta ctg ata aat ctt tac aag ctt gta aaa tct cag ata     2024
 Ala Lys Arg Leu Leu Ile Asn Leu Tyr Lys Leu Val Lys Ser Gln Ile
 485                 490                 495                 500

 tct gtt tat tct gag ctc aac aag att gaa gta agt ttt cgg gag cta     2072
 Ser Val Tyr Ser Glu Leu Asn Lys Ile Glu Val Ser Phe Arg Glu Leu
                 505                 510                 515

 cag aaa tta aat caa gaa aag aat aat aga gga tta tat tca att gaa     2120
 Gln Lys Leu Asn Gln Glu Lys Asn Asn Arg Gly Leu Tyr Ser Ile Glu
             520                 525                 530

 gtg ctg gag ctc ttc tgatattatc aattctcctt catagacatt ttataaagct     2175
 Val Leu Glu Leu Phe 
         535

 cttttatgtg aactcttgct tcatccaggc aagaacggtg ttttgtttgc gaccatctca   2235

 gtgtcaagag aaacgtgtca gtgagtacct ggaccatcac ttaactgatg ctccggggta   2295

 ggactgcagg tttcacatga acctgttcta ggctgtggac attggtgtgg agaggttctg   2355

 caatttttta aaaatatgta actgggttga ttttaagtaa aattatttgt gtattgataa   2415

 aagtctaatt tcttatcatg tgttttgaat tttttctttt aataaaaaat gaccattgaa   2475

 gcagtgaaaa aaaaaaaaaa                                               2495




      <210> 129
      <211> 795
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(525)

      <220>
      <221> misc_feature
      <222> (1)...(795)
      <223> n = a,t,c or g

      <400> 129
 gaggcatggc cagccacccg ttcccaggcg tccgggccgt ttgaccagaa ttacccatgt     60

 ggtgattacc aacgcgggcg cgaacgggca gataggtccg gctgctctga aggcggtgta    120

 tgacatggcc cgcaagggtg cccgtgatga aattcagaca cagatgcgtg atggtggcct    180

 gttctccgga ggtggacg  atg aag acc ttc cgc tgg aaa gtg aaa ccc ggt     231
                      Met Lys Thr Phe Arg Trp Lys Val Lys Pro Gly
                        1               5                  10

 atg gat gtg gct tcg gtc cct tct gta aga aag gtg cgc ttt ggt gat      279
 Met Asp Val Ala Ser Val Pro Ser Val Arg Lys Val Arg Phe Gly Asp
              15                  20                  25

 ggc tat tct cag cga gcg cct gcc ggg ctg aat gcc aac ctg aaa acg      327
 Gly Tyr Ser Gln Arg Ala Pro Ala Gly Leu Asn Ala Asn Leu Lys Thr
          30                  35                  40

 tac agc gtg acg ctt tct gtc ccc cgt gag gag gcc acg gta ctg gag      375
 Tyr Ser Val Thr Leu Ser Val Pro Arg Glu Glu Ala Thr Val Leu Glu
      45                  50                  55

 tcg ttt ctg gaa gag cac ggg ggc tgg aaa tcc ttt ctg tgg acg ccg      423
 Ser Phe Leu Glu Glu His Gly Gly Trp Lys Ser Phe Leu Trp Thr Pro
  60                  65                  70                  75

 cct tat gag tgg cgg cag ata aag gtg acc tgc gca aaa tgg tcg tcg      471
 Pro Tyr Glu Trp Arg Gln Ile Lys Val Thr Cys Ala Lys Trp Ser Ser
                  80                  85                  90

 cgg gtc agt atg ctg cgt gtt gag ttc agc gca gag ttt gaa cag gtg      519
 Arg Val Ser Met Leu Arg Val Glu Phe Ser Ala Glu Phe Glu Gln Val
              95                 100                 105

 gtg aac tgatgcagga tatccggcag gaaacactga atgaatgcac ccgtgcggag       575
 Val Asn 


 cagtcggcca gcgtggtgct ctgggaaatc gacctgacag aggtcggtgg agaacgttat    635

 tttttctgta atgagcagaa cgaaaaaggt gagccggtca cctggcaggg gcgacagtat    695

 cagccgtatc ccattcaggg gagcggtttt gaactgaatg gcaaaggcac cagtacgcgc    755

 cccncgctgn cggtgtcctc aagcggtcct tttcaccgcg                          795




      <210> 130
      <211> 767
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (289)..(669)

      <400> 130
 gcacgaggtc gtgaaagggc cgcaaaaagg ccgaggcgga gttgacggct gcgactccat     60

 tttgtaggcc gcttatttgt gtgcatccac ggcgattctt cccgcagagt tgtgaagcga    120

 aaggcttaca attaaaagga agaaaaaaaa ataaagataa ttcgggagta caattgacaa    180

 agcgtgtggg tcgctcagcc tccagcagta actgctgatc tccagttctt ggagggttcc    240

 ggtgagaaga acgcccctac tgcggtactg aggaagcggc aggaggag atg cgg ccc     297
                                                      Met Arg Pro
                                                        1

 ctg gac ata gac gag gtg gaa gcg cct gag gaa gtg gag gtg ctg gag      345
 Leu Asp Ile Asp Glu Val Glu Ala Pro Glu Glu Val Glu Val Leu Glu
       5                  10                  15

 ccc gag gag gat ttc gag cag ttc ctg ctc ccg gtc atc aac gag atg      393
 Pro Glu Glu Asp Phe Glu Gln Phe Leu Leu Pro Val Ile Asn Glu Met
  20                  25                  30                  35

 cgc gag gac atc gcg tct ctt ata cgc gag cac ggg cgg gcg tac ctg      441
 Arg Glu Asp Ile Ala Ser Leu Ile Arg Glu His Gly Arg Ala Tyr Leu
                  40                  45                  50

 cgg acc agg agc aag ctg tgg gag atg gac aat atg ctt atc cag atc      489
 Arg Thr Arg Ser Lys Leu Trp Glu Met Asp Asn Met Leu Ile Gln Ile
              55                  60                  65

 aaa acg cag gtg gag gcc tcg gag gag agc gcc ctc aat cac gtg cag      537
 Lys Thr Gln Val Glu Ala Ser Glu Glu Ser Ala Leu Asn His Val Gln
          70                  75                  80

 cac ccg agt ggc gaa gcc gac gag aga gtg tcg gag ttg tgc gag aag      585
 His Pro Ser Gly Glu Ala Asp Glu Arg Val Ser Glu Leu Cys Glu Lys
      85                  90                  95

 gct gag gag aaa gcc aag gag att gcg aag atg gca gag atg ctg gtc      633
 Ala Glu Glu Lys Ala Lys Glu Ile Ala Lys Met Ala Glu Met Leu Val
 100                 105                 110                 115

 gag ctc gtc tgg cga ata gag aga agc gag tct tct tgaa ggaggagatc      683
 Glu Leu Val Trp Arg Ile Glu Arg Ser Glu Ser Ser 
                 120                 125

 cggtggtaag gtcggaaact agctggagct tggatgaaac tcagtagtcg gcctaagcat    743

 gggttaaacc cggcctgtaa aagt                                           767




      <210> 131
      <211> 841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(506)

      <400> 131
 ggcagcggcc gtggcaggct ggctgggtac cggctgtcgc tgacccagga gaagctgcct     60

 gtctacatca gcctgggctg cagcgcgctg ccgccgcggg gccggcagcc   atg gcc     116
                                                          Met Ala
                                                            1

 aag gac atc ctg ggt gaa gca ggg cta cac ttt gat gaa ctg aac aag      164
 Lys Asp Ile Leu Gly Glu Ala Gly Leu His Phe Asp Glu Leu Asn Lys
           5                  10                  15

 ctg agg gtg ttg gac cca gag gtt acc cag cag acc ata gag ctg aag      212
 Leu Arg Val Leu Asp Pro Glu Val Thr Gln Gln Thr Ile Glu Leu Lys
      20                  25                  30

 gaa gag tgc aaa gac ttt gtg gac aaa att ggc cag ttt cag aaa ata      260
 Glu Glu Cys Lys Asp Phe Val Asp Lys Ile Gly Gln Phe Gln Lys Ile
  35                  40                  45                  50

 gtt ggt ggt tta att gag ctt gtt gat caa ctt gca aaa gaa gca gaa      308
 Val Gly Gly Leu Ile Glu Leu Val Asp Gln Leu Ala Lys Glu Ala Glu
                  55                  60                  65

 aat gaa aag atg aag gcc atc ggt gct cgg aac ttg ctc aaa tct ata      356
 Asn Glu Lys Met Lys Ala Ile Gly Ala Arg Asn Leu Leu Lys Ser Ile
              70                  75                  80

 gca aag cag aga gaa gct caa cag cag caa ctt caa gcc cta ata gca      404
 Ala Lys Gln Arg Glu Ala Gln Gln Gln Gln Leu Gln Ala Leu Ile Ala
          85                  90                  95

 gaa aag aaa atg cag cta gaa agg tat cgg gtt gaa tat gaa gct ttg      452
 Glu Lys Lys Met Gln Leu Glu Arg Tyr Arg Val Glu Tyr Glu Ala Leu
     100                 105                 110

 tgt aaa gta gaa gca gaa caa aat gaa ttt att gac caa ttt att ttt      500
 Cys Lys Val Glu Ala Glu Gln Asn Glu Phe Ile Asp Gln Phe Ile Phe
 115                 120                 125                 130

 cag aaa tgaactgaaa atttcgcttt tatagtagga aggcaaaaca aaaaaaagcc       556
 Gln Lys 


 tctcaaaacc aaaaaaacct ctgtagcatt ccagcggctt gaccaatgac ctatgtcaca    616

 agaggtggcg tgtaaggaat gcagccccct gaagacagca ctacaagtct gggggagcca    676

 gttttaacat cagtgcacag ctgctgctgg tggccctgca gtgtacgttc tcacctctta    736

 tgcttagttg gaactaagca gtttgtaaac tttcatcctt ttttttgtaa attcacaaag    796

 ctttggaagg agaagcaata aatttttgtt ttcaaaaaaa aaaaa                    841




      <210> 132
      <211> 1011
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(760)

      <400> 132
 gcgctgcggc acagctggtt tgagcaactg aactggaaac aag  atg cag gac ccc      55
                                                  Met Gln Asp Pro
                                                    1

 aac gca gac act gaa tgg aat gac atc tta cgc aaa aag ggt atc tta      103
 Asn Ala Asp Thr Glu Trp Asn Asp Ile Leu Arg Lys Lys Gly Ile Leu
   5                  10                  15                  20

 ccc ccc aag gaa agt ctg aaa gaa ttg gaa gag gag gca gaa gag gag      151
 Pro Pro Lys Glu Ser Leu Lys Glu Leu Glu Glu Glu Ala Glu Glu Glu
                  25                  30                  35

 cag cgc atc ctc cag cag tca gtg gtg aaa aca tat gaa gat atg act      199
 Gln Arg Ile Leu Gln Gln Ser Val Val Lys Thr Tyr Glu Asp Met Thr
              40                  45                  50

 ttg gaa gag ctg gag gat cat gaa gac gag ttt aat gag gag gat gaa      247
 Leu Glu Glu Leu Glu Asp His Glu Asp Glu Phe Asn Glu Glu Asp Glu
          55                  60                  65

 cgt gct att gaa atg tac aga cgg cgg aga ctg gct gag tgg aaa gca      295
 Arg Ala Ile Glu Met Tyr Arg Arg Arg Arg Leu Ala Glu Trp Lys Ala
      70                  75                  80

 act aaa ctg aag aat aaa ttt gga gaa gtt ttg gag atc tca ggg aag      343
 Thr Lys Leu Lys Asn Lys Phe Gly Glu Val Leu Glu Ile Ser Gly Lys
  85                  90                  95                 100

 gat tat gtt caa gaa gtt acc aaa gct ggc gag ggc ttg tgg gtc atc      391
 Asp Tyr Val Gln Glu Val Thr Lys Ala Gly Glu Gly Leu Trp Val Ile
                 105                 110                 115

 ttg cac ctt tac aaa caa gga att ccc ctc tgt gcc ctg ata aat cag      439
 Leu His Leu Tyr Lys Gln Gly Ile Pro Leu Cys Ala Leu Ile Asn Gln
             120                 125                 130

 cac ctc agt gga ctt gcc agg aag ttt cct gat gtc aaa ttt atc aaa      487
 His Leu Ser Gly Leu Ala Arg Lys Phe Pro Asp Val Lys Phe Ile Lys
         135                 140                 145

 gcc att tca aca acc tgc ata ccc aat tat cct gat agg aat ctg ccc      535
 Ala Ile Ser Thr Thr Cys Ile Pro Asn Tyr Pro Asp Arg Asn Leu Pro
     150                 155                 160

 acg ata ttt gtt tac ctg gaa gga gat atc aag gct cag ttt att ggt      583
 Thr Ile Phe Val Tyr Leu Glu Gly Asp Ile Lys Ala Gln Phe Ile Gly
 165                 170                 175                 180

 cct ctg gtg ttt ggc ggc atg aac ctg aca aga gat gag ttg gaa tgg      631
 Pro Leu Val Phe Gly Gly Met Asn Leu Thr Arg Asp Glu Leu Glu Trp
                 185                 190                 195

 aaa ctg tct gaa tct gga gca att atg aca gac ctg gag gaa aac cct      679
 Lys Leu Ser Glu Ser Gly Ala Ile Met Thr Asp Leu Glu Glu Asn Pro
             200                 205                 210

 aag aag ccg att gaa gac gtg ttg ctg tcc tca gtg cgg cgc tct gtc      727
 Lys Lys Pro Ile Glu Asp Val Leu Leu Ser Ser Val Arg Arg Ser Val
         215                 220                 225

 ctc atg aag agg gac agc gat tcc gag ggt gac tgaggcta cagcttctat      778
 Leu Met Lys Arg Asp Ser Asp Ser Glu Gly Asp 
     230                 235

 cacatgccga actttcttgt gacaaattgt ctggattttt taaaaaagga aaaagcaaga    838

 atgaatcctt gtggttttta gttttgtata aattatgttt caaatcttta cattttggaa    898

 ataatcattg ctggagattc tgttaaatat tttggaactc tttttttttt taaattatag    958

 tatttcctct aaaaaaaatt aaaaccagcc atttgtatgg caaaaaaaaa aaa          1011




      <210> 133
      <211> 547
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (170)..(373)

      <400> 133
 atgaggcact cgactgcttc gtttatgcgc tggcggcgct gcgcatcagt atttcccgct     60

 ggcagctgga tctcagtgcg ctgctggcga gcctgcagga agaggatggt gcagcaacca    120

 acaagaaaac actggcagat tacgcccgtg ccttatccgg agaggatga    atg acg     175
                                                          Met Thr
                                                            1

 cga cag gaa gaa ctt gcc gct gcc cgt gcg gca ctg cat gac ctg atg      223
 Arg Gln Glu Glu Leu Ala Ala Ala Arg Ala Ala Leu His Asp Leu Met
           5                  10                  15

 aca ggt aaa cgg gtg gca aca gta cag aaa gac gga cga agg gtg gag      271
 Thr Gly Lys Arg Val Ala Thr Val Gln Lys Asp Gly Arg Arg Val Glu
      20                  25                  30

 ttt acg gcc act tcc gtg tct gac ctg aaa aaa tat att gca gag ctg      319
 Phe Thr Ala Thr Ser Val Ser Asp Leu Lys Lys Tyr Ile Ala Glu Leu
  35                  40                  45                  50

 gaa gtg cag acc ggc atg aca cag cga cgc agg gga cct gca gga ttt      367
 Glu Val Gln Thr Gly Met Thr Gln Arg Arg Arg Gly Pro Ala Gly Phe
                  55                  60                  65

 tat gta tgaaaacgcc caccattccc acccttctgg ggccggacgg catgacatcg       423
 Tyr Val 


 ctgcgcgaat atgccggtta tcacggcggt ggcagcggat ttggagggca gttgcggtcg    483

 tggaacccac cgagtgaaag tgtggatgca gccctgttgc ccaactttac ccgtggcaat    543

 ggcc                                                                 547




      <210> 134
      <211> 481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (222)..(338)

      <400> 134
 accatcgtgg ctcgctgcaa cctccgcctc ccaggagaat tgcttgaacc ctggaggcgg     60

 aggttgccgt gagctaacat tgcgccccta cactccagcc tgccaacaga gcaagactcc    120

 gtctcaaaaa taaaaaaagg atctactttt gagaatactg tcattggttg ataaaataca    180

 gcagaaactt gtgaagaagc tattttccat attcacctgg c    atg ttt gga gat     233
                                                  Met Phe Gly Asp
                                                    1

 gat tgc cat caa ctt tgt gac tgt gaa gga gaa acc ttc tgc cac cca      281
 Asp Cys His Gln Leu Cys Asp Cys Glu Gly Glu Thr Phe Cys His Pro
   5                  10                  15                  20

 aaa act gaa aaa tgc ctc tgc ccc cgt ggg aga act gga gcc aga tgt      329
 Lys Thr Glu Lys Cys Leu Cys Pro Arg Gly Arg Thr Gly Ala Arg Cys
                  25                  30                  35

 gat gct ggt tagtctc ctgtattggg cgttcagcat ggatgttgcc tttttctgac      385
 Asp Ala Gly 


 ctcaagacaa ctatccaact ttccctgtgt ccttcacgat gcaaccacta aagctctact    445

 gaagtctcta attctgagaa ggcaccttaa aaattt                              481




      <210> 135
      <211> 553
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(545)

      <400> 135
 ttcggcacga gggaactggt gctccacaga ggtgggcccg gtggtttggt ccggcctggc     60

 ctactggacc agcctgtgct cggtcggcca cggctctgct gggctcctgg cgccgcctcc    120

 tcccagcccg ccgcgggctg cgcgcttctg tgggtggggg aaggcaggac tgactcaga     179                                                                 
 atg aca acg gca aca cga caa gaa gtc ctt ggc ctc tac cgc agc att      227
 Met Thr Thr Ala Thr Arg Gln Glu Val Leu Gly Leu Tyr Arg Ser Ile
   1               5                  10                  15

 ttc agg ctt gcg agg aaa tgg cag gcg aca tca ggg cag atg gaa gac      275
 Phe Arg Leu Ala Arg Lys Trp Gln Ala Thr Ser Gly Gln Met Glu Asp
              20                  25                  30

 acc atc aaa gaa aaa cag tac ata cta aat gaa gcc aga acg ctg ttc      323
 Thr Ile Lys Glu Lys Gln Tyr Ile Leu Asn Glu Ala Arg Thr Leu Phe
          35                  40                  45

 cgg aaa aac aaa aat ctc acg gac aca gac cta att aaa cag tgt ata      371
 Arg Lys Asn Lys Asn Leu Thr Asp Thr Asp Leu Ile Lys Gln Cys Ile
      50                  55                  60

 gat gaa tgc aca gcc agg att gaa att gga ctg cat tac aag att cct      419
 Asp Glu Cys Thr Ala Arg Ile Glu Ile Gly Leu His Tyr Lys Ile Pro
  65                  70                  75                  80

 tac cca agg cca att cat ctg cct cca atg ggc ctt acc cca ctc cga      467
 Tyr Pro Arg Pro Ile His Leu Pro Pro Met Gly Leu Thr Pro Leu Arg
                  85                  90                  95

 ggc cgg gga ctt cga agc caa gag aaa ctg agg aaa ctt tcc aaa cca      515
 Gly Arg Gly Leu Arg Ser Gln Glu Lys Leu Arg Lys Leu Ser Lys Pro
             100                 105                 110

 gta tat ctc aga tct cat gat gaa gtt tcc taatctag                     553
 Val Tyr Leu Arg Ser His Asp Glu Val Ser 
         115                 120





      <210> 136
      <211> 1067
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(1029)

      <400> 136
 gcacgaggat cccgcagcaa actc   atg gca ccg ccc cga atc ggg acg cac      51
                              Met Ala Pro Pro Arg Ile Gly Thr His
                                1               5

 aat ggc acc ttc cac tgc gac gag gca ctg gca tgc gca ctg ctt cgc       99
 Asn Gly Thr Phe His Cys Asp Glu Ala Leu Ala Cys Ala Leu Leu Arg
  10                  15                  20                  25

 ctc ctg ccg gag tac cgg gat gca gag att gtg cgg acc cgg gat ccc      147
 Leu Leu Pro Glu Tyr Arg Asp Ala Glu Ile Val Arg Thr Arg Asp Pro
                  30                  35                  40

 gaa aaa ctc gct tcc tgt gac atc gtg gtg gac gtg ggg ggc gag tac      195
 Glu Lys Leu Ala Ser Cys Asp Ile Val Val Asp Val Gly Gly Glu Tyr
              45                  50                  55

 cac cct cgg aga cac cga tat gac cat cac cag agg tct ttc aca gag      243
 His Pro Arg Arg His Arg Tyr Asp His His Gln Arg Ser Phe Thr Glu
          60                  65                  70

 acc atg agc tcc ctg tcc cct ggg aag ccg tgg cag acc aag ctg agc      291
 Thr Met Ser Ser Leu Ser Pro Gly Lys Pro Trp Gln Thr Lys Leu Ser
      75                  80                  85

 agt gcg gga ctc atc tat ctg cac ttc ggg cac aag ctg ctg gcc cag      339
 Ser Ala Gly Leu Ile Tyr Leu His Phe Gly His Lys Leu Leu Ala Gln
  90                  95                 100                 105

 ttg ctg ggc act agt gaa gag gac agc atg gtg ggc acc ctc tat gac      387
 Leu Leu Gly Thr Ser Glu Glu Asp Ser Met Val Gly Thr Leu Tyr Asp
                 110                 115                 120

 aag atg tat gag aac ttt gtg gag gag gtg gat gct gtg gac aat ggg      435
 Lys Met Tyr Glu Asn Phe Val Glu Glu Val Asp Ala Val Asp Asn Gly
             125                 130                 135

 atc tcc cag tgg gca gag ggg gag cct cga tat gca ctg acc act acc      483
 Ile Ser Gln Trp Ala Glu Gly Glu Pro Arg Tyr Ala Leu Thr Thr Thr
         140                 145                 150

 ctg agt gca cga gtt gct cga ctt aat cct acc tgg aac cac ccc gac      531
 Leu Ser Ala Arg Val Ala Arg Leu Asn Pro Thr Trp Asn His Pro Asp
     155                 160                 165

 caa gac act gag gca ggg ttc aag cgt gca atg gat ctg gtt caa gag      579
 Gln Asp Thr Glu Ala Gly Phe Lys Arg Ala Met Asp Leu Val Gln Glu
 170                 175                 180                 185

 gag ttt ctg cag aga tta gat ttc tac caa cac agc tgg ctg cca gcc      627
 Glu Phe Leu Gln Arg Leu Asp Phe Tyr Gln His Ser Trp Leu Pro Ala
                 190                 195                 200

 cgg gcc ttg gtg gaa gag gcc ctt gcc cag cga ttc cag gtg gac cca      675
 Arg Ala Leu Val Glu Glu Ala Leu Ala Gln Arg Phe Gln Val Asp Pro
             205                 210                 215

 agt gga gag att gtg gaa ctg gcg aaa ggt gca tgt ccc tgg aag gag      723
 Ser Gly Glu Ile Val Glu Leu Ala Lys Gly Ala Cys Pro Trp Lys Glu
         220                 225                 230

 cat ctc tac cac ctg gaa tct ggg ctg tcc cct cca gtg gcc atc ttc      771
 His Leu Tyr His Leu Glu Ser Gly Leu Ser Pro Pro Val Ala Ile Phe
     235                 240                 245

 ttt gtt atc tac act gac cag gct gga cag tgg cga ata cag tgt gtg      819
 Phe Val Ile Tyr Thr Asp Gln Ala Gly Gln Trp Arg Ile Gln Cys Val
 250                 255                 260                 265

 ccc aag gag ccc cac tca ttc caa agc cgg ctg ccc ctg cca gag cca      867
 Pro Lys Glu Pro His Ser Phe Gln Ser Arg Leu Pro Leu Pro Glu Pro
                 270                 275                 280

 tgg cgg ggt ctt cgg gac gag gcc ctg gac cag gtc agt ggg atc cct      915
 Trp Arg Gly Leu Arg Asp Glu Ala Leu Asp Gln Val Ser Gly Ile Pro
             285                 290                 295

 ggc tgc atc ttc gtc cat gca agc ggc ttc att ggc ggt cac cgc acc      963
 Gly Cys Ile Phe Val His Ala Ser Gly Phe Ile Gly Gly His Arg Thr
         300                 305                 310

 cga gag ggt gcc ttg agc atg gcc cgt gcc acc ttg gcc cag cgc tca     1011
 Arg Glu Gly Ala Leu Ser Met Ala Arg Ala Thr Leu Ala Gln Arg Ser
     315                 320                 325

 tac ctc cca caa atc tcc tagtct aataaaacct tccatctcat aaaaaaaaaa     1065
 Tyr Leu Pro Gln Ile Ser 
 330                 335

 aa                                                                  1067




      <210> 137
      <211> 7072
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (375)..(1652)

      <400> 137
 accagaatgc aaaggtgggc agcgaagcca tccaggtgct ccccgccttc ccccgcgagg     60

 tccaacgcct gcccgagcct gccaagtcct gccgccagcg gcagctggaa gccagaaagg    120

 cagcagccga gaagaagaag attcagaagg agaagctgag cactccggag aagatcaagc    180

 aggaggccct ggagctggcg ggcattacgt cggacccagg cctgtctttg aagggtggat    240

 tgtcccagca aggcctgaag ccctccctca aggtggagcc gcagaaccac ttcagctcct    300

 tcaagtacag cggcaacgcg gtggtggaga gctactcggt gctgggcaac tgccggccct    360

 ccgaccctta cagc  atg aac agc gtg tac tcc tac cac tcc tac tat gca     410
                  Met Asn Ser Val Tyr Ser Tyr His Ser Tyr Tyr Ala
                    1               5                  10

 cag ccc agc ctg acc tcc gtc aat ggc ttc cac tcc aag tac gct ctc      458
 Gln Pro Ser Leu Thr Ser Val Asn Gly Phe His Ser Lys Tyr Ala Leu
          15                  20                  25

 ccg tct ttt agc tac tgt ggc ttt cca tcc agc aac ccc gtc ttc ccc      506
 Pro Ser Phe Ser Tyr Cys Gly Phe Pro Ser Ser Asn Pro Val Phe Pro
      30                  35                  40

 tct cag ttc ctg ggt cct ggt gcc tgg ggg cac agt ggc agc agt ggc      554
 Ser Gln Phe Leu Gly Pro Gly Ala Trp Gly His Ser Gly Ser Ser Gly
  45                  50                  55                  60

 agt ttt gag aag aag cca gac ctc cac gct ctg cac aac agc ctg agc      602
 Ser Phe Glu Lys Lys Pro Asp Leu His Ala Leu His Asn Ser Leu Ser
                  65                  70                  75

 ccg gcc tac ggt ggt gct gag ttt gcc gag ctg ccc agc cag gct gtt      650
 Pro Ala Tyr Gly Gly Ala Glu Phe Ala Glu Leu Pro Ser Gln Ala Val
              80                  85                  90

 ccc aca gac gcc cac cac ccc act cct cac cac cag cag cct gcg tac      698
 Pro Thr Asp Ala His His Pro Thr Pro His His Gln Gln Pro Ala Tyr
          95                 100                 105

 cca ggc ccc aag gag tat ctg ctt ccc aag gcc ccc cta ctc cac tca      746
 Pro Gly Pro Lys Glu Tyr Leu Leu Pro Lys Ala Pro Leu Leu His Ser
     110                 115                 120

 gtg tcc agg gac ccc tcc ccc ttt gcc cag agc tcc aac tgc tac aac      794
 Val Ser Arg Asp Pro Ser Pro Phe Ala Gln Ser Ser Asn Cys Tyr Asn
 125                 130                 135                 140

 aga tcc atc aag caa gag cca gta gac ccg ctg acc cag gct gag cct      842
 Arg Ser Ile Lys Gln Glu Pro Val Asp Pro Leu Thr Gln Ala Glu Pro
                 145                 150                 155

 gtg ccc aga gac gct ggc aag atg ggc aag aca cct ctg tcc gag gtg      890
 Val Pro Arg Asp Ala Gly Lys Met Gly Lys Thr Pro Leu Ser Glu Val
             160                 165                 170

 tct cag aat gga gga ccc agt cac ctt tgg gga cag tac tca gga ggc      938
 Ser Gln Asn Gly Gly Pro Ser His Leu Trp Gly Gln Tyr Ser Gly Gly
         175                 180                 185

 cca agc atg tcc ccc aag agg act aac ggt gtg ggt ggc agc tgg ggt      986
 Pro Ser Met Ser Pro Lys Arg Thr Asn Gly Val Gly Gly Ser Trp Gly
     190                 195                 200

 gtg ttc tcg tct ggg gag agt cct gcc atc gtc cct gac aag ctc agt     1034
 Val Phe Ser Ser Gly Glu Ser Pro Ala Ile Val Pro Asp Lys Leu Ser
 205                 210                 215                 220

 tcc ttt ggg gcc agc tgc ctg gcc cct tcc cac ttc aca gat ggc cag     1082
 Ser Phe Gly Ala Ser Cys Leu Ala Pro Ser His Phe Thr Asp Gly Gln
                 225                 230                 235

 tgg ggg ctg ttc ccc ggt gag ggg cag cag gca gct tcc cac tct gga     1130
 Trp Gly Leu Phe Pro Gly Glu Gly Gln Gln Ala Ala Ser His Ser Gly
             240                 245                 250

 gga cgg ctg cga ggc aaa ccg tgg agc ccc tgc aag ttt ggg aac agc     1178
 Gly Arg Leu Arg Gly Lys Pro Trp Ser Pro Cys Lys Phe Gly Asn Ser
         255                 260                 265

 acc tcg gcc ttg gct ggg ccc agc ctg act gag aag ccg tgg gcg ctg     1226
 Thr Ser Ala Leu Ala Gly Pro Ser Leu Thr Glu Lys Pro Trp Ala Leu
     270                 275                 280

 ggg gca ggg gat ttc aac tcg gcc ctg aaa ggt agt cct ggg ttc caa     1274
 Gly Ala Gly Asp Phe Asn Ser Ala Leu Lys Gly Ser Pro Gly Phe Gln
 285                 290                 295                 300

 gac aag ctg tgg aac ccc atg aaa gga gag gag ggc agg att cca gcc     1322
 Asp Lys Leu Trp Asn Pro Met Lys Gly Glu Glu Gly Arg Ile Pro Ala
                 305                 310                 315

 gca ggg gcc agc cag ctg gtc ttc tac cag cac aag aac ctc aac cag     1370
 Ala Gly Ala Ser Gln Leu Val Phe Tyr Gln His Lys Asn Leu Asn Gln
             320                 325                 330

 ccc aac cac ggg ctg gcc ctc tgg gaa gcc aag atg aag cag ctg gcg     1418
 Pro Asn His Gly Leu Ala Leu Trp Glu Ala Lys Met Lys Gln Leu Ala
         335                 340                 345

 gag agg gca cgg gca cgg cag gag gag gct gcc cgg ctg ggc ctg ggc     1466
 Glu Arg Ala Arg Ala Arg Gln Glu Glu Ala Ala Arg Leu Gly Leu Gly
     350                 355                 360

 cag cag gag gcc aag ctc tac ggg aag aag cgc aag tgg ggg ggc act     1514
 Gln Gln Glu Ala Lys Leu Tyr Gly Lys Lys Arg Lys Trp Gly Gly Thr
 365                 370                 375                 380

 gtg gtt gct gag ccc cag cag aaa gag aag aag ggg gtc gtc ccc acc     1562
 Val Val Ala Glu Pro Gln Gln Lys Glu Lys Lys Gly Val Val Pro Thr
                 385                 390                 395

 cgg cag gca ctg gct gtg ccc aca gac tcg gcg gtc acc gtg tcc tcc     1610
 Arg Gln Ala Leu Ala Val Pro Thr Asp Ser Ala Val Thr Val Ser Ser
             400                 405                 410

 tat gcc tac acg aag gtc act ggc ccc tac agc cgc tgg atc taggtgc     1659
 Tyr Ala Tyr Thr Lys Val Thr Gly Pro Tyr Ser Arg Trp Ile 
         415                 420                 425

 cagggagcca gcgtacctca gcgtcgggcc tggcccgagc tgtctctgtg gtgcttttgc   1719

 cctcatacct gggggcgggt tgggggtgca gaagtctttt tatctctata tacatatata   1779

 gatgcgcata tcatatatat gtatttatgg tccaaacctc agaactgacc cgcccctccc   1839

 ttacccccac ttccccagca ctttgaagaa gaaactacgg ctgtcgggtg atttttccgt   1899

 gatcttaata tttatatctc caagttgtcc ccccccttgt ctggggggtt tttattttta   1959

 ttttctcttt gtttttaaaa ctctatcctt gtatatcaca ataatggaaa gaaagtttat   2019

 agtatccttt cacaaaggag tagttttaaa ttccatttaa aatgtgtatt tattggattt   2079

 tttaaaagcg acaatagtaa tggtaaagga tgggcaggaa aggccagtag tgctcccccg   2139

 cccagtctcg ctgggtctgg cgagccaagc ccctcgggcg ctggcgaggt cctcagccat   2199

 ctgcccctcg agagccaagc gcggacggta gccacccagt tcatccctcc cgacatacac   2259

 cccttccctt tggggaaggg agcctcagga cagcttctgt cctctctgat aggatgggag   2319

 agtctgcaga aaaccatctg gggtcccttt tccagtcccc ggcttggagt cgaagggcag   2379

 atgcacccca ggccagcccc acgagatgct ggcatagctt tccccagaaa ccaggttgga   2439

 agtagatggc ttcaagcttg ctagtctcca cactgaatcc tctgtccgtt atttatggag   2499

 tcacacgatg tcatggttca ctaggcagca cctcacgctg gagctggagt gcgaggttct   2559

 taggggccgt gcccaccatg ttgccaagcc aatgcatgct gagctgaagg aatttgtctt   2619

 agtggcagtt ttttaaaaaa tgcccccaaa gtctatgctg atactgaaaa agggctactg   2679

 tatctttaaa aacaggaagt tgaacccaag ctgtgaaaag ccagtggtgc tctgtgcatg   2739

 gtgctgtgcg gagcctggtg ctgtagtgtt gtgctgggac tttcttgact cttgggcagg   2799

 tcacatccta caggagctca gcagaccagt gtaacaacag ttaatgcatc tatcctgatc   2859

 cctgaatttc cacattggac aatggtgcat gcctcacacc tgagcctgct tcctccatgc   2919

 tgtcattggg ttcgggggcc tacacttaac aattttaaag tgcaagagtc aaacattttc   2979

 aacaggttgc tataattttc ctccctaatt ggtgccattt ctccatttga tcattttctt   3039

 tttttccttt ctcccctctt catccacttt aatatagctg ttctgaaatt ctggtgcatt   3099

 cattcggttc tttgaaatga gaatgtggtg cttaattttt gtgacgttgt cgagagaggt   3159

 tgggcctgat gggagcaaca ctcatcatca ccaagtcaaa ctttgttgga gtgttggttt   3219

 ttcttgtgat attagcagaa atgatctcat gctagccatg tggatgtgtg tgtggtgaat   3279

 ggggggcttc atcaggacac acagagggga atgtggccac acggtggatg accaccaagc   3339

 cctgagatga acaggtattt actgagcagt tgtattcaga tatgggtctt catgaatcat   3399

 gtttaacaat cagatgaccg ctataggcaa gttcctgagc ttccgggtgc cttgagtaag   3459

 agctgagaac cggcctgctg ggtgtttact gtatctgttt ggaagcactg gcggagggtc   3519

 gttgtaagat gtcctgagca tttatgtggt ctggttttaa ctgtaaatag tgaaagattt   3579

 ttttaagcac ttttgcctag atttaaacag caacttgaaa aaaaaagtat gttttaacat   3639

 gtaattgtgg gagaaattgt aaatagtagc cgaatattta atgtgctttg tctatcctcc   3699

 acttttacca tattctgtaa agttgcattt attttacagg acaaaaaaat gaaatattat   3759

 tgcttttgaa ataaataccc aagagcttat caggacttag aattattcag aactcagatt   3819

 tataggaaaa cctctgacct tcagtttgac aagctaaagg aagcagagtc tttaatgagc   3879

 atgctaattt tctagttttg aggaaaaatt gggtccttta aatgctattt tgcttatcgc   3939

 atcagtactt ttatgcaggt ctcatttgac tccgtgctta ggtagatgcg ggggtgcctt   3999

 gaaaacttca ttttaaatga tcttaagcaa gaaatacaat attttacgaa acatttggag   4059

 aatgtgaccg tctgtatgac ccgtggaagc cccaggttgg ctgttggttt ggaaggtccc   4119

 gagtgtaacc caggtgattc tgatacttgg catgtgtgaa tcttcctgat gtatgttaaa   4179

 taaactcttc ccctcatcac cctttggtag gaaagccatt agatgaaagg agaaaccaat   4239

 acaagctaaa agcatgcgac gtctgtcccc cagcccaaac agccttggtt catcagtttc   4299

 tgcagtagga gataggctgc tgagaggtga gtcaagaggc agtctccatt ggatgtcccc   4359

 actccccgca gaatggcgtt tccagagtta ggcggtgtgg ttgccgtgct caagcccatg   4419

 ctgatttgta cactacatgt ctaacctacc tcaaatctca gtcattaaaa ttagcatgct   4479

 ttagacatat atttaaaaag taactatgca cagctcttta tccccccctt gctgctgaag   4539

 ctttcttaaa gagaaaaatc aaatttttat tttttactgg cactatcatt ttttaagtcc   4599

 taaagatgat taacagacat ttttatcatg agaagaaaaa taaagccatt gcaactaaag   4659

 aacctaacag catgaccaag ttcgaagagt catattatag caacggaaat cgatggcgtc   4719

 ttagtcatct ccccagtgtg ccctgtccac ggacaccatc cacgtgcagt gcaaacattt   4779

 ggttcctttt ctgctctgtt ttgttttccc tgcctgttgc gtgcaaggga agtgcttgta   4839

 aagttctgtg ctacgagatt tttaaaataa aaatcgcttc gcagcaggtt ctcacaaaat   4899

 aactggtgct agctcaagaa atcatcatct gaccatcaga aatcttgact aaaggtgttg   4959

 catggatttg ggggtctttc ggtttttggt tttgggtctg gcttttagca gggccaatgt   5019

 ttcccacacc ccggcttcat gggtactgct ttgccttctc accaaggtga cgatggtgtg   5079

 cgtggaaaga gatgataccc caccgccccc tcttggtcct tccaccagcc tcttttggga   5139

 acagtagttt gcagagcaag ggatttttaa agcgctaaag gaaagaagta gcagagctta   5199

 actgctttgt accacacagc agtagatgtg caaggacggt tgacaatgag tcgatgataa   5259

 cctaatttca ttgagagaaa cccagccaga cttgcttcta gaggtttaat caccatgaga   5319

 tctcaaacca aggcaaagct ggtggaaaac tatatgatat ccctgacgtg cctcaaccag   5379

 tatctctttc cttttgttac tgaagtgtgt tttatggact aggaagcatt tttatgaatt   5439

 gaaatagtct aaataaaatg gtgctatggt gttttaatgt gactgtccct gatcctgtct   5499

 tgctgaggtg ctatcaacgt tctgaaacca caaccaacca aaaacaaggt gggctccagt   5559

 ctcttggctt tttttttttt tccctcccct cttttggtgc tgtcttagac ccgtttaccg   5619

 tgctataatc tgctctgagc agtgttgtgt tgtgttgtat tgttcttccc ttggtggcca   5679

 aacaaagcaa gtcgagaagg cagctatctc cctttctgtg atcgggagtg ggcctgcctg   5739

 gcttggcagg tgctttttgg ttccacacct gtcttctcag gcttgatgtg aaagaaaggg   5799

 cgaagggttt tttgagtttt tgtttttgag gaaggggagt tgggtacttc tgcctctcct   5859

 agcatgatag gcattctcat agccagggac agattttctc ctgcagccca gggtgctaag   5919

 cagacatctc tgggagtccc aagggcacac caagggagac cagatggatc tccttcctcc   5979

 cctggcactg gctgggacca tggtgggcag gggcttcatt ctctgaccca gcgttgcttc   6039

 tgcctctcat tggtaacccc ttatgttcgg actaaaggaa ggagctttct ttgctcactc   6099

 gatgccactg aggctgcttt ttagttggtg ctaacctaaa tttcttcttg ggtccacaga   6159

 agttgatgtt ttaaaaactc accaggaagc tccattttgt gtcatccact gtcacaataa   6219

 tttttttaaa tacctcaaaa acaggacatc atgacaactt cagtaaagta gattccatga   6279

 gggtctgata cctgcaggtt gtccgtctga tgacatactt gaccttgaaa aatctggggt   6339

 cattttgttt ttcattcttc agcagttaag atagcggaac gccgaaagga aggagcgtag   6399

 ttggctgtat ttcatgttta agttttgctt ttgaataaaa tgtgaatttc ctatgcccat   6459

 ctcattgagc tttctcagtc attgttgctg tcatttgaaa tgactccctc aaaacctagt   6519

 tttattagcc agctgcctct gctgtagtac atggccaact tcaacatacc ctggaccaaa   6579

 acatttttga ggtgcatacc cccaacataa gttacacagt cccacatcca ggtgcacaga   6639

 gtgcgagtgc actccgcgag tgcgggggga ggggcggccc cctctggtgc tcccagccct   6699

 tcctcctgca gagctgcagg caagagcaga gcaataggct tctcccctga gcagagaccg   6759

 cagcacagaa atgcaaggtc taaagttgct ttttgcctaa gaatcagcga gcgatttggc   6819

 ctacttcctc attggcttct attctgatat cagggatgct ttttgtagtg gtattgtttg   6879

 ctccctcttc gcgttttgac tacccgtcat tcaggggtaa ctcatcactc ttcacacggg   6939

 gatttaaatt aagaaactaa ttggctcatg tgaacattcc aaattttctt ggtttcaata   6999

 cccttttttt ttcttttgag gggaaaagag gggagaaaaa caggagtgat gtcatttctt   7059

 tttcatgtat tcc                                                      7072




      <210> 138
      <211> 859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (87)..(737)

      <400> 138
 ggctgctcct cggggcggcg accgggctca cgcgcgggcc cgccgcggcc ttcaccgccg     60

 cgcgctctga cgccggcata agggcc atg tgt tct gaa att att ttg agg caa     113
                              Met Cys Ser Glu Ile Ile Leu Arg Gln
                                1               5

 gaa gtt ttg aaa gat ggt ttc cac aga gac ctt tta atc aaa gtg aag      161
 Glu Val Leu Lys Asp Gly Phe His Arg Asp Leu Leu Ile Lys Val Lys
  10                  15                  20                  25

 ttt ggg gaa agc att gag gac ttg cac acc tgc cgt ctc tta att aaa      209
 Phe Gly Glu Ser Ile Glu Asp Leu His Thr Cys Arg Leu Leu Ile Lys
                  30                  35                  40

 cag gac att cct gca gga ctt tat gtg gat ccg tat gag ttg gct tca      257
 Gln Asp Ile Pro Ala Gly Leu Tyr Val Asp Pro Tyr Glu Leu Ala Ser
              45                  50                  55

 tta cga gag aga aac ata aca gag gca gtg atg gtt tca gaa aat ttt      305
 Leu Arg Glu Arg Asn Ile Thr Glu Ala Val Met Val Ser Glu Asn Phe
          60                  65                  70

 gat ata gag gcc cct aac tat ttg tcc aag gag tct gaa gtt ctc att      353
 Asp Ile Glu Ala Pro Asn Tyr Leu Ser Lys Glu Ser Glu Val Leu Ile
      75                  80                  85

 tat gcc aga cga gat tca cag tgc att gac tgt ttt caa gcc ttt ttg      401
 Tyr Ala Arg Arg Asp Ser Gln Cys Ile Asp Cys Phe Gln Ala Phe Leu
  90                  95                 100                 105

 cct gtg cac tgc cgc tat cat cgg ccg cac agt gaa gat gga gaa gcc      449
 Pro Val His Cys Arg Tyr His Arg Pro His Ser Glu Asp Gly Glu Ala
                 110                 115                 120

 tcg att gtg gtc aat aac cca gat ttg ttg atg ttt tgt gac caa gag      497
 Ser Ile Val Val Asn Asn Pro Asp Leu Leu Met Phe Cys Asp Gln Glu
             125                 130                 135

 ttc ccg att ttg aaa tgc tgg gct cac tca gaa gtg gca gcc cct tgt      545
 Phe Pro Ile Leu Lys Cys Trp Ala His Ser Glu Val Ala Ala Pro Cys
         140                 145                 150

 gct ttg gag aat gag gat atc tgc caa tgg aac aag atg aag tat aaa      593
 Ala Leu Glu Asn Glu Asp Ile Cys Gln Trp Asn Lys Met Lys Tyr Lys
     155                 160                 165

 tca gta tat aag aat gtg att cta caa gtt cca gtg gga ctg act gta      641
 Ser Val Tyr Lys Asn Val Ile Leu Gln Val Pro Val Gly Leu Thr Val
 170                 175                 180                 185

 cat acc tct cta gta tgt tct gtg act ctg ctc att aca atc ctg tgc      689
 His Thr Ser Leu Val Cys Ser Val Thr Leu Leu Ile Thr Ile Leu Cys
                 190                 195                 200

 tct aca ttg atc ctt gta gca gtt ttc aaa tat ggc cat ttt tcc cta      737
 Ser Thr Leu Ile Leu Val Ala Val Phe Lys Tyr Gly His Phe Ser Leu 
             205                 210                 215

 taagttttat gtagttaaat gcttcctaga aacctaaata agatctatta atttctgacg    797

 agaggtgttc ttctagaatt aattactttt atcttttgtc ttcatttgtg gccaaaatac    857

 ga                                                                   859




      <210> 139
      <211> 1706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (920)..(1246)

      <400> 139
 tcctctatat aaatgcgtag gggttttagt taaatgtcct ttgaagtata cttgaggagg     60

 gtgacgggcg gtgtgtaccc ccttcagggc cctgttcaac taagcactct actcttagtt    120

 tactggtaaa tccaccttcg acccttaagt ttcataaggg ctatcgtagt tttctggggt    180

 agaaaatgta gcccatttct tgccacctca tgggctacac cttgacctaa cgtctttacg    240

 tgggtacttg cgcttacttt gtagccttca tcagggtttg ctgaagatgg cggtatatag    300

 gctgagcaag aggtggtgag gttgatcggg gtttatcgat tacagaacag gctcctctag    360

 agggatatga agcaccgcca ggtcctttga gttttaagct gtggctcgta gtgttctggc    420

 gagcagtttt gttgatttaa ctgttgaggt ttagggctaa gcatagtggg gtatctaatc    480

 ccagtttggg tcttagctat tgtgtgttca gatatgttaa agccactttc gtagtctatt    540

 ttgtgtcaac tggagttttt tacaactcag gtgagtttta gctttattgg ggagggggtg    600

 atctaaaaca ctctttacgc cggcttctat tgacttgggt taatcgtgtg accgcggtgg    660

 ctggcacgaa attgaccaac cctggggtta gtatagctta gttaaacttt cgtttattgc    720

 taaaggttaa tcactgctgt ttcccgtggg ggtgtggcta ggctaagcgt tttgagctgc    780

 attgctgcgt gcttgatgct tgtccctttt gatcgtggtg atttagaggg tgaactcact    840

 ggaatgggga tgcttgcatg tgtaatctta ctaagagcta atagaaaggc taggaccaaa    900

 ccagaaacct ccaattctc atg tgg aag ccc atg ccc tca ccc tcc aac atg     952
                      Met Trp Lys Pro Met Pro Ser Pro Ser Asn Met
                        1               5                  10

 aaa gcc tct gca gca ctt ctg tgt ctg ctg ctc aca gca gct gct ttc     1000
 Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala Phe
              15                  20                  25

 agc ccc cag ggg ctt gct cag cca gtt ggg att aat act tca act acc     1048
 Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Thr Ser Thr Thr
          30                  35                  40

 tgc tgc tac aga ttt atc aat aag aaa atc cct aag cag agg ctg gag     1096
 Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu Glu
      45                  50                  55

 agc tac aga agg acc acc agt agc cac tgt ccc cgg gaa gct gta atc     1144
 Ser Tyr Arg Arg Thr Thr Ser Ser His Cys Pro Arg Glu Ala Val Ile
  60                  65                  70                  75

 ttc aag acc aaa ctg gac aag gag atc tgt gct gac ccc aca cag aag     1192
 Phe Lys Thr Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln Lys
                  80                  85                  90

 tgg gtc cag gac ttt atg aag cac ctg gac aag aaa acc caa act cca     1240
 Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Thr Gln Thr Pro
              95                 100                 105

 aag ctt tgaacattca tgactgaact gaaaacaagc catgacttga gaaacaaata      1296
 Lys Leu 


 atttgtatac cctgtccttt ctcagagtgg ttctgagatt attttaatct aattctaagg   1356

 aatatgagct ttatgtaata atgtgaatca tggtttttct tagtagattt taaaagttat   1416

 taatatttta atttaatctt ccatggattt tggtgggttt tgaacataaa gccttggatg   1476

 tatatgtcat ctcagtgctg taaaaactgt gggatgctcc tcccttctct acctcatggg   1536

 ggtattgtat aagtccttgc aagaatcagt gcaaagattt gctttaattg ttaagatatg   1596

 atgtccctat ggaagcatat tgttattata taattacata tttgcatatg tatgactccc   1656

 aaattttcac ataaaataga tttttgtata acaaaaacaa aaaaaaaaaa              1706




      <210> 140
      <211> 946
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (172)..(789)

      <400> 140
 ctccgcccca tccccagggg ccgcctcccc cggggcggcc tccaggctgc cgagacctat     60

 aaaggcgcca ggttttctca atgaagccgg gacgcactcc ggagcgcact gcgtggtcgc    120

 accctacccg ggctgccttg gaagtcgtcc ccgccgcccc tccgcaccgg c atg aag     177
                                                          Met Lys
                                                            1

 ctc atc gtg ggc atc gga ggc atg acc aac ggc ggc aag acc acg ctg      225
 Leu Ile Val Gly Ile Gly Gly Met Thr Asn Gly Gly Lys Thr Thr Leu
           5                  10                  15

 acc aac agc ctg ctc aga gcc ctg ccc aac tgc tgc gtg atc cat cag      273
 Thr Asn Ser Leu Leu Arg Ala Leu Pro Asn Cys Cys Val Ile His Gln
      20                  25                  30

 gat gac ttc ttc aag ccc caa gac caa ata gca gtt ggg gaa gac ggc      321
 Asp Asp Phe Phe Lys Pro Gln Asp Gln Ile Ala Val Gly Glu Asp Gly
  35                  40                  45                  50

 ttc aaa cag tgg gac gtg ctg gag tct ctg gac atg gag gcc atg ctg      369
 Phe Lys Gln Trp Asp Val Leu Glu Ser Leu Asp Met Glu Ala Met Leu
                  55                  60                  65

 gac acc gtg cag gcc tgg ctg agc agc ccg cag aag ttt gcc cgt gcc      417
 Asp Thr Val Gln Ala Trp Leu Ser Ser Pro Gln Lys Phe Ala Arg Ala
              70                  75                  80

 cac ggg gtc agc gtc cag cca gag gcc tcg gac acc cac atc ctc ctt      465
 His Gly Val Ser Val Gln Pro Glu Ala Ser Asp Thr His Ile Leu Leu
          85                  90                  95

 ctg gaa ggc ttc ctg ctc tac agc tac aat acc cgc aac tac aca gtc      513
 Leu Glu Gly Phe Leu Leu Tyr Ser Tyr Asn Thr Arg Asn Tyr Thr Val
     100                 105                 110

 cct gat ccc ccc ggc ctc ttc gat ggc cac gtg tgg ccc atg tac cag      561
 Pro Asp Pro Pro Gly Leu Phe Asp Gly His Val Trp Pro Met Tyr Gln
 115                 120                 125                 130

 aag tat agg cag gag atg gag gcc aac ggt gtg gaa gtg gtc tac ctg      609
 Lys Tyr Arg Gln Glu Met Glu Ala Asn Gly Val Glu Val Val Tyr Leu
                 135                 140                 145

 gac ggc atg aag tcc cga gag gag ctc ttc cgt gaa gtc ctg gaa gac      657
 Asp Gly Met Lys Ser Arg Glu Glu Leu Phe Arg Glu Val Leu Glu Asp
             150                 155                 160

 att cag aac tcg ctg ctg aac cgc tcc cag gaa tca gcc ccc tcc ccg      705
 Ile Gln Asn Ser Leu Leu Asn Arg Ser Gln Glu Ser Ala Pro Ser Pro
         165                 170                 175

 gct cgc cca gcc agg aca cag gga ccc gga cgc gga tgc ggc cac aga      753
 Ala Arg Pro Ala Arg Thr Gln Gly Pro Gly Arg Gly Cys Gly His Arg
     180                 185                 190

 acg gcc agg cct gca gcg tcc cag cag gac agc atg tgag cgtttcccta      803
 Thr Ala Arg Pro Ala Ala Ser Gln Gln Asp Ser Met 
 195                 200                 205

 tgggggtgtc tgtacgtagg agagtggagg ccccactccc agttgggcgt cccggagctc    863

 agggactgag ccccaagacg cctctgtaac ctcgctgcag cttcagtagt aaactgggtc    923

 ctgttttttt aaaaaaaaaa aaa                                            946




      <210> 141
      <211> 750
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (48)..(626)

      <400> 141
 agcgctccgg gcctggaatc cctacgcgtc cctttgggtt tagcacg  atg agc tca      56
                                                      Met Ser Ser
                                                        1

 atc ggc act ggg tat gac ctg tca gcc tct aca ttc tct cct gac gga      104
 Ile Gly Thr Gly Tyr Asp Leu Ser Ala Ser Thr Phe Ser Pro Asp Gly
       5                  10                  15

 aga gtt ttt caa gtt gaa tat gct atg aag gct gtg gaa aat agt agt      152
 Arg Val Phe Gln Val Glu Tyr Ala Met Lys Ala Val Glu Asn Ser Ser
  20                  25                  30                  35

 aca gct att gga atc aga tgc aaa gat ggt gtt gtc ttt ggg gta gaa      200
 Thr Ala Ile Gly Ile Arg Cys Lys Asp Gly Val Val Phe Gly Val Glu
                  40                  45                  50

 aaa tta gtc ctt tct aaa ctt tat gaa gaa ggt tcc aac aaa aga ctt      248
 Lys Leu Val Leu Ser Lys Leu Tyr Glu Glu Gly Ser Asn Lys Arg Leu
              55                  60                  65

 ttt aat gtt gat cgg cat gtt gga atg gca gta gca ggt ttg ttg gca      296
 Phe Asn Val Asp Arg His Val Gly Met Ala Val Ala Gly Leu Leu Ala
          70                  75                  80

 gat gct cgt tct tta gca gac ata gca aga gaa gaa gct tcc aac ttc      344
 Asp Ala Arg Ser Leu Ala Asp Ile Ala Arg Glu Glu Ala Ser Asn Phe
      85                  90                  95

 aga tct aac ttt ggc tac aac att cca cta aaa cat ctt gca gac aga      392
 Arg Ser Asn Phe Gly Tyr Asn Ile Pro Leu Lys His Leu Ala Asp Arg
 100                 105                 110                 115

 gtg gcc atg tat gtg cat gca tat aca ctc tac agt gct gtt aga cct      440
 Val Ala Met Tyr Val His Ala Tyr Thr Leu Tyr Ser Ala Val Arg Pro
                 120                 125                 130

 ttt ggc tgc aga att tac ata gta cat gac gaa gtt aag gat aaa gct      488
 Phe Gly Cys Arg Ile Tyr Ile Val His Asp Glu Val Lys Asp Lys Ala
             135                 140                 145

 ttt gaa cta gaa ctc agc tgg gtt ggt gaa tta act aat gga aga cat      536
 Phe Glu Leu Glu Leu Ser Trp Val Gly Glu Leu Thr Asn Gly Arg His
         150                 155                 160

 gaa att gtt cca aaa gat ata aga gaa gaa gca gag aaa tat gct aag      584
 Glu Ile Val Pro Lys Asp Ile Arg Glu Glu Ala Glu Lys Tyr Ala Lys
     165                 170                 175

 gaa tct ctg aag gaa gaa gat gaa tca gat gat gat aat atg taacatt      633
 Glu Ser Leu Lys Glu Glu Asp Glu Ser Asp Asp Asp Asn Met 
 180                 185                 190

 tactccagca tctattgtat tttaaatttc tactccagtc caatgtaact atttagccct    693

 ggattataca tactgtccaa ttttcattaa atttttgtct tataaaaaaa aaaaaaa       750




      <210> 142
      <211> 2539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (314)..(2482)

      <400> 142
 tctcgacgcc gagacactgc tggtggtact cgatgtagat cacgtggatg gcaggagcag     60

 tggcaaagga ctttcaactg acagacaagc atgagatggt ggtcagctac ctcccactca    120

 gccatattgc agcacagatg atggacatct gggtacccat aaagattggg gcgctcacat    180

 actttgctca agcagatgct ctcaaggggt gactggcaac catgccgtgg agacactcaa    240

 gcaattctgt ggagaaggcc atggaatgag gagctgagac ttcctgccaa caaccagtca    300

 tctagacctg agc   atg cag aat tcc gag ggt gga gcg gat tcg cca gcg     349
                  Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala
                    1               5                  10

 tcc gtg gct ctg cgt ccc tcg gcg gca gcc ccg cct gtg cca gcc tcc      397
 Ser Val Ala Leu Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser
          15                  20                  25

 ccg cag agg gtg ttg gtc cag gca gcc agc tcc aat ccc aaa ggg gcc      445
 Pro Gln Arg Val Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala
      30                  35                  40

 cag atg cag ccg atc tcc ctc ccc aga gtt cag cag gta ccc cag cag      493
 Gln Met Gln Pro Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln
  45                  50                  55                  60

 gtg cag ccg gtg cag cac gtg tat cct gcc cag gtg cag tac gtg gaa      541
 Val Gln Pro Val Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu
                  65                  70                  75

 ggg gga gac gcc gtc tac acc aat gga gcc ata cga aca gcc tac acc      589
 Gly Gly Asp Ala Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr
              80                  85                  90

 tac aac ccc gag cct cag atg tac gcc ccc agc agc acg gct tct tac      637
 Tyr Asn Pro Glu Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr
          95                 100                 105

 ttc gag gcc cca ggc ggt gcc cag gtg acc gtg gca gcc tcg tcc ccg      685
 Phe Glu Ala Pro Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro
     110                 115                 120

 cca gcg gtc ccc tcc cac agc atg gtg ggc atc acc atg gat gtc ggg      733
 Pro Ala Val Pro Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly
 125                 130                 135                 140

 ggg agc ccc atc gtc tcc agc gcg gga gcc tat ctc atc cac ggg ggg      781
 Gly Ser Pro Ile Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly
                 145                 150                 155

 atg gac agc acc aga cac tcc ctg gcc cac acc tcc cgc tca tcg ccc      829
 Met Asp Ser Thr Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro
             160                 165                 170

 gcc acg ctt gaa atg gcg att gaa aac ctc caa aaa agc gaa gga atc      877
 Ala Thr Leu Glu Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile
         175                 180                 185

 aca tca cac aaa agc ggt tta ctc aac agc cat ctc cag tgg ctg ttg      925
 Thr Ser His Lys Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu
     190                 195                 200

 gat aat tat gaa aca gcg gaa ggt gtg agt ctc ccc aga agt tct ctt      973
 Asp Asn Tyr Glu Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu
 205                 210                 215                 220

 tac aac cac tac ctt cgg cac tgc cag gag cac aag cta gac cca gtg     1021
 Tyr Asn His Tyr Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val
                 225                 230                 235

 aac gcc gcc tcc ttc ggg aaa ctg atc cgt tct gtg ttt atg ggg ctg     1069
 Asn Ala Ala Ser Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu
             240                 245                 250

 aga acg cgg cgg ctg ggc acc agg ggc aac tcg aag tac cat tac tat     1117
 Arg Thr Arg Arg Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr
         255                 260                 265

 ggg att cgt ctg aag ccg gac tca cca ctg aac cgg ctg cag gag gac     1165
 Gly Ile Arg Leu Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp
     270                 275                 280

 acg cag tac atg gcc atg cgg cag cag ccc atg cac cag aag ccc agg     1213
 Thr Gln Tyr Met Ala Met Arg Gln Gln Pro Met His Gln Lys Pro Arg
 285                 290                 295                 300

 tac cgg cca gcc cag aag acg gac agc ctc ggg gac agc ggc tcc cac     1261
 Tyr Arg Pro Ala Gln Lys Thr Asp Ser Leu Gly Asp Ser Gly Ser His
                 305                 310                 315

 agc ggc ctg cac agc act ccg gaa cag acc atg gcc gtg cag agc cag     1309
 Ser Gly Leu His Ser Thr Pro Glu Gln Thr Met Ala Val Gln Ser Gln
             320                 325                 330

 cac cac cag cag tac ata gat gtc tcc cac gtc ttc ccc gag ttc cca     1357
 His His Gln Gln Tyr Ile Asp Val Ser His Val Phe Pro Glu Phe Pro
         335                 340                 345

 gcg ccc gac ctg ggc agc ttc ctg ctg cag gac ggc gtc aca ctg cac     1405
 Ala Pro Asp Leu Gly Ser Phe Leu Leu Gln Asp Gly Val Thr Leu His
     350                 355                 360

 gac gtc aag gcc ctg cag ctg gtg tac aga cgg cac tgc gag gca act     1453
 Asp Val Lys Ala Leu Gln Leu Val Tyr Arg Arg His Cys Glu Ala Thr
 365                 370                 375                 380

 gta gat gtg gtg atg aac ctc cag ttc cac tac atc gag aag ctg tgg     1501
 Val Asp Val Val Met Asn Leu Gln Phe His Tyr Ile Glu Lys Leu Trp
                 385                 390                 395

 ctc tcc ttc tgg aac tct aag gcc tcc tcc agc gac ggc ccc acc tct     1549
 Leu Ser Phe Trp Asn Ser Lys Ala Ser Ser Ser Asp Gly Pro Thr Ser
             400                 405                 410

 ctt cct gcc agt gac gaa gac ccc gag ggc gcc gtc ctg ccc aag gac     1597
 Leu Pro Ala Ser Asp Glu Asp Pro Glu Gly Ala Val Leu Pro Lys Asp
         415                 420                 425

 aag ctt atc tcc ctg tgt cag tgc gac ccc atc ctc agg tgg atg agg     1645
 Lys Leu Ile Ser Leu Cys Gln Cys Asp Pro Ile Leu Arg Trp Met Arg
     430                 435                 440

 agc tgc gac cac atc ctc tac cag gcg ctg gtg gag att ctc atc ccc     1693
 Ser Cys Asp His Ile Leu Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro
 445                 450                 455                 460

 gac gtg ctg agg ccg gtc ccc agt acc ttg aca cag gcc atc cgt aac     1741
 Asp Val Leu Arg Pro Val Pro Ser Thr Leu Thr Gln Ala Ile Arg Asn
                 465                 470                 475

 ttt gcc aag agc ttg gaa ggc tgg ttg aca aat gcc atg agt gac ttc     1789
 Phe Ala Lys Ser Leu Glu Gly Trp Leu Thr Asn Ala Met Ser Asp Phe
             480                 485                 490

 cca caa cag gtc atc cag acc aag gtg ggc gtc gtc agt gcc ttc gcc     1837
 Pro Gln Gln Val Ile Gln Thr Lys Val Gly Val Val Ser Ala Phe Ala
         495                 500                 505

 cag acg ctg cgg cgc tac acg tcc ctc aac cac ctg gcg cag gcg gcc     1885
 Gln Thr Leu Arg Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala
     510                 515                 520

 cgg gcg gtg ctg cag aac acg tcc cag atc aac cag atg ctc agc gac     1933
 Arg Ala Val Leu Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp
 525                 530                 535                 540

 ctc aac cgc gtg gac ttt gcc aac gtg cag gag cag gcc tcg tgg gtg     1981
 Leu Asn Arg Val Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val
                 545                 550                 555

 tgc cag tgc gag gag agt gtg gtg cag cgg ctg gag cag gat ttc aag     2029
 Cys Gln Cys Glu Glu Ser Val Val Gln Arg Leu Glu Gln Asp Phe Lys
             560                 565                 570

 ctg acc ctg cag cag cag agc tcc ctg gac cag tgg gcc agc tgg ctg     2077
 Leu Thr Leu Gln Gln Gln Ser Ser Leu Asp Gln Trp Ala Ser Trp Leu
         575                 580                 585

 gac agt gtg gtc acc cag gtc ctg aag cag cat gcc ggc agc ccc agc     2125
 Asp Ser Val Val Thr Gln Val Leu Lys Gln His Ala Gly Ser Pro Ser
     590                 595                 600

 ttc ccc aag gcc gcc cgg cag ttc ttg ctg aaa tgg tcc ttt tac agc     2173
 Phe Pro Lys Ala Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser
 605                 610                 615                 620

 tcc atg gtg atc cgg gac ctg acc ctg cgc agc gct gcc agc ttc ggc     2221
 Ser Met Val Ile Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly
                 625                 630                 635

 tcc ttc cac ctc atc cgc ctg ctc tac gac gag tac atg ttc tac ctg     2269
 Ser Phe His Leu Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu
             640                 645                 650

 gtg gag cac cgc gtc gcg gag gcc acc gga gag acg ccg atc gct gtg     2317
 Val Glu His Arg Val Ala Glu Ala Thr Gly Glu Thr Pro Ile Ala Val
         655                 660                 665

 atg gga gag ttc aac gat ctc gcc tct ctg tcg ctg acg ctg ctc gac     2365
 Met Gly Glu Phe Asn Asp Leu Ala Ser Leu Ser Leu Thr Leu Leu Asp
     670                 675                 680

 aaa gat gac atg ggc gat gag cag cgt ggc agc gag gcg ggc cca gac     2413
 Lys Asp Asp Met Gly Asp Glu Gln Arg Gly Ser Glu Ala Gly Pro Asp
 685                 690                 695                 700

 gcc cgc agc ctg ggt gag ccc ctg gta aag cgg gag cgc agt gac ccc     2461
 Ala Arg Ser Leu Gly Glu Pro Leu Val Lys Arg Glu Arg Ser Asp Pro
                 705                 710                 715

 aac cac tcc ctg cag ggc atc ta gcagccccgg ccggcgcctc ctcgaggttc     2514
 Asn His Ser Leu Gln Gly Ile 
             720

 caaaagatgc cgcctggtca ctctg                                         2539




      <210> 143
      <211> 3321
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (568)..(2742)

      <400> 143
 attattggaa cgacgacttc gtgcagaagc aggaggatgg tggttgtggg tcctctgtgt     60

 tcagccctgt taacctttaa accagcacgg ccgccgcagc tgtgagccta gcacctgatc    120

 agtggagagc tgtggattgc atgtttgttt gccattgccc ccgccaccct gcaagttgca    180

 ccttctagaa tcagcaagcc aagctcctct cacccagcgt aatgatgcgg aaatgcaaat    240

 gcaccatcat gttgtgaccc atattgcgaa aattagaaaa aaggaagttg tgtttcgcta    300

 ttgcacgaag ttcagcccag aggagaaact cgctcgcctt cagaagacag tacctcctaa    360

 atggctctac tttgaacctg ctgggcaagg aagagatttt caaggaaacc atctaccgtg    420

 tgcaagctcc tgccggccaa ccccagaccc cagcacggag ccaggcgcct gtgcccgccg    480

 accctcagca tcctcctcag aaaggctggt ggcatcagga agcccctggc cagcctccac    540

 ctgagcccag tgagctcagc tttaagg    atg gag tca ggc agg ggg tcc tca     591
                                  Met Glu Ser Gly Arg Gly Ser Ser
                                    1               5

 acc cct cca gga ccc att gct gcc cta ggg atg cca gac act ggg cct      639
 Thr Pro Pro Gly Pro Ile Ala Ala Leu Gly Met Pro Asp Thr Gly Pro
      10                  15                  20

 ggc agt tcc tcc cta ggg aag ctt cag gcg ctc cct gtt ggg ccc aga      687
 Gly Ser Ser Ser Leu Gly Lys Leu Gln Ala Leu Pro Val Gly Pro Arg
  25                  30                  35                  40

 gcc cac tgt ggg gac cct gtc agc ctg gct gca gca ggg gac ggc tct      735
 Ala His Cys Gly Asp Pro Val Ser Leu Ala Ala Ala Gly Asp Gly Ser
                  45                  50                  55

 cca gac ata ggc ccc acg gga gag ctg agt ggt agc tta aag atc ccc      783
 Pro Asp Ile Gly Pro Thr Gly Glu Leu Ser Gly Ser Leu Lys Ile Pro
              60                  65                  70

 aac cgg gac agc ggg atc gac agt ccc tcc tcc agt gtg gct gga gag      831
 Asn Arg Asp Ser Gly Ile Asp Ser Pro Ser Ser Ser Val Ala Gly Glu
          75                  80                  85

 aac ttt ccc tgc gag gag ggc ttg gag gct ggc cca agc ccc act gta      879
 Asn Phe Pro Cys Glu Glu Gly Leu Glu Ala Gly Pro Ser Pro Thr Val
      90                  95                 100

 ctg ggg gcg cac gca gag atg gcc ctg gac agc cag gtc ccg aag gtc      927
 Leu Gly Ala His Ala Glu Met Ala Leu Asp Ser Gln Val Pro Lys Val
 105                 110                 115                 120

 acc ccc cag gag gag gcg gac agc gac gtg ggt gag gaa cct gac tct      975
 Thr Pro Gln Glu Glu Ala Asp Ser Asp Val Gly Glu Glu Pro Asp Ser
                 125                 130                 135

 gag aac acc ccc cag aag gct gac aag gat gcc ggc ctg gcc cag cac     1023
 Glu Asn Thr Pro Gln Lys Ala Asp Lys Asp Ala Gly Leu Ala Gln His
             140                 145                 150

 tct ggc ccc cag aag ctt ctc cac att gcc cag gag ctc ctg cac acc     1071
 Ser Gly Pro Gln Lys Leu Leu His Ile Ala Gln Glu Leu Leu His Thr
         155                 160                 165

 gag gag acc tat gtg aag cgg ctg cac ctg ctg gac cag gtt ttc tgc     1119
 Glu Glu Thr Tyr Val Lys Arg Leu His Leu Leu Asp Gln Val Phe Cys
     170                 175                 180

 acc agg ctg acg gat gcg ggg atc cct cca gaa gtc atc atg ggc ata     1167
 Thr Arg Leu Thr Asp Ala Gly Ile Pro Pro Glu Val Ile Met Gly Ile
 185                 190                 195                 200

 ttc tct aac atc tcc tcc atc cac cgc ttc cac ggg cag ttc ctg ctg     1215
 Phe Ser Asn Ile Ser Ser Ile His Arg Phe His Gly Gln Phe Leu Leu
                 205                 210                 215

 ccg gag ctg aag acg cgg atc acg gag gag tgg gac aca aac cca cgg     1263
 Pro Glu Leu Lys Thr Arg Ile Thr Glu Glu Trp Asp Thr Asn Pro Arg
             220                 225                 230

 ctc ggg gac atc ctg cag aag ctg gcc cca ttc ctg aag atg tac ggc     1311
 Leu Gly Asp Ile Leu Gln Lys Leu Ala Pro Phe Leu Lys Met Tyr Gly
         235                 240                 245

 gag tat gtc aag aac ttt gac cga gcc gta ggg ctg gtg agc acg tgg     1359
 Glu Tyr Val Lys Asn Phe Asp Arg Ala Val Gly Leu Val Ser Thr Trp
     250                 255                 260

 acc cag cgc tcc cca ctg ttt aaa gac gtc gtc cac agc atc cag aag     1407
 Thr Gln Arg Ser Pro Leu Phe Lys Asp Val Val His Ser Ile Gln Lys
 265                 270                 275                 280

 cag gag gta tgc ggg aac ctg acg ctg cag cac cac atg ctg gag ccc     1455
 Gln Glu Val Cys Gly Asn Leu Thr Leu Gln His His Met Leu Glu Pro
                 285                 290                 295

 gtg cag agg gtc ccc cgg tac gag ctg ctg ctc aag gac tat ctg aag     1503
 Val Gln Arg Val Pro Arg Tyr Glu Leu Leu Leu Lys Asp Tyr Leu Lys
             300                 305                 310

 agg ctc ccg cag gac gcc cca gac cgg aag gat gcg gag agg tcc ttg     1551
 Arg Leu Pro Gln Asp Ala Pro Asp Arg Lys Asp Ala Glu Arg Ser Leu
         315                 320                 325

 gag ctc atc tcc aca gcc gcc aac cac tcc aat gct gcc att cgg aaa     1599
 Glu Leu Ile Ser Thr Ala Ala Asn His Ser Asn Ala Ala Ile Arg Lys
     330                 335                 340

 gtg gag aaa atg cac aag ctc ttg gag gtg tac gag cag ctg ggt ggg     1647
 Val Glu Lys Met His Lys Leu Leu Glu Val Tyr Glu Gln Leu Gly Gly
 345                 350                 355                 360

 gaa gaa gac att gtc aac ccg gcc aat gaa ctg atc aag gag ggc caa     1695
 Glu Glu Asp Ile Val Asn Pro Ala Asn Glu Leu Ile Lys Glu Gly Gln
                 365                 370                 375

 atc cag aaa ctg tca gcc aag aac ggc acc ccc cag gac cgc cac ctc     1743
 Ile Gln Lys Leu Ser Ala Lys Asn Gly Thr Pro Gln Asp Arg His Leu
             380                 385                 390

 ttc ctg ttc aac agc atg atc ctt tac tgt gtg ccc aag ctg cgg ctc     1791
 Phe Leu Phe Asn Ser Met Ile Leu Tyr Cys Val Pro Lys Leu Arg Leu
         395                 400                 405

 atg ggc cag aag ttc agc gtc cgg gag aag atg gac atc tca ggc ctc     1839
 Met Gly Gln Lys Phe Ser Val Arg Glu Lys Met Asp Ile Ser Gly Leu
     410                 415                 420

 cag gtg cag gat atc gtc aag cca aac aca gca cat aca ttc atc ata     1887
 Gln Val Gln Asp Ile Val Lys Pro Asn Thr Ala His Thr Phe Ile Ile
 425                 430                 435                 440

 acg gga aga aaa agg tcc ctg gag ctg cag acg cgg aca gag gaa gag     1935
 Thr Gly Arg Lys Arg Ser Leu Glu Leu Gln Thr Arg Thr Glu Glu Glu
                 445                 450                 455

 aag aaa gaa tgg att cag atc atc cag gcc acc atc gag aag cac aaa     1983
 Lys Lys Glu Trp Ile Gln Ile Ile Gln Ala Thr Ile Glu Lys His Lys
             460                 465                 470

 cag aac agc gaa acc ttc aag gct ttt ggt ggc gcc ttc agc cag gat     2031
 Gln Asn Ser Glu Thr Phe Lys Ala Phe Gly Gly Ala Phe Ser Gln Asp
         475                 480                 485

 gag gac ccc agc ctc tct cca gac atg cct atc acg agc acc agc cct     2079
 Glu Asp Pro Ser Leu Ser Pro Asp Met Pro Ile Thr Ser Thr Ser Pro
     490                 495                 500

 gtg gag cct gtg gtg acc acc gaa ggc agt tcg ggt gca gca ggg ctc     2127
 Val Glu Pro Val Val Thr Thr Glu Gly Ser Ser Gly Ala Ala Gly Leu
 505                 510                 515                 520

 gag ccc aga aaa cta tcc tct aag acc aga cgt gac aag gag aag cag     2175
 Glu Pro Arg Lys Leu Ser Ser Lys Thr Arg Arg Asp Lys Glu Lys Gln
                 525                 530                 535

 agc tgt aag agc tgt ggt gag acc ttc aac tcc atc acc aag agg agg     2223
 Ser Cys Lys Ser Cys Gly Glu Thr Phe Asn Ser Ile Thr Lys Arg Arg
             540                 545                 550

 cat cac tgc aag ctg tgt ggg gcg gtc atc tgt ggg aag tgc tcc gag     2271
 His His Cys Lys Leu Cys Gly Ala Val Ile Cys Gly Lys Cys Ser Glu
         555                 560                 565

 ttc aag gcc gag aac agc cgg cag agc cgt gtc tgc aga gat tgt ttc     2319
 Phe Lys Ala Glu Asn Ser Arg Gln Ser Arg Val Cys Arg Asp Cys Phe
     570                 575                 580

 ctg aca cag cca gtg gcc cct gag agc aca gag aag aca ccc act gca     2367
 Leu Thr Gln Pro Val Ala Pro Glu Ser Thr Glu Lys Thr Pro Thr Ala
 585                 590                 595                 600

 gac ccc cag ccc agc ctg ctc tgc ggc ccc ctg cgg ctg tca gag agc     2415
 Asp Pro Gln Pro Ser Leu Leu Cys Gly Pro Leu Arg Leu Ser Glu Ser
                 605                 610                 615

 gga gag acc tgg agc gag gtg tgg gcc gcc atc ccc atg tca gat ccc     2463
 Gly Glu Thr Trp Ser Glu Val Trp Ala Ala Ile Pro Met Ser Asp Pro
             620                 625                 630

 cag gtg ctg cac ctg cag gga ggc agc cag gac ggc cgg ctg ccc cgc     2511
 Gln Val Leu His Leu Gln Gly Gly Ser Gln Asp Gly Arg Leu Pro Arg
         635                 640                 645

 acc atc cct ctc ccc agc tgc aaa ctg agt gtg ccg gac cct gag gag     2559
 Thr Ile Pro Leu Pro Ser Cys Lys Leu Ser Val Pro Asp Pro Glu Glu
     650                 655                 660

 agg ctg gac tcg ggg cat gtg tgg aag ctg cag tgg gcc aag cag tcc     2607
 Arg Leu Asp Ser Gly His Val Trp Lys Leu Gln Trp Ala Lys Gln Ser
 665                 670                 675                 680

 tgg tac ctg agc gcc tcc tcc gca gag ctg cag cag cag tgg ctg gaa     2655
 Trp Tyr Leu Ser Ala Ser Ser Ala Glu Leu Gln Gln Gln Trp Leu Glu
                 685                 690                 695

 acc cta agc act gct gcc cat ggg gac acg gcc cag gac agc ccg ggg     2703
 Thr Leu Ser Thr Ala Ala His Gly Asp Thr Ala Gln Asp Ser Pro Gly
             700                 705                 710

 gcc ctg cag ctt cag gtc cct atg ggc gca gct gct ccg tgagctgagt      2752
 Ala Leu Gln Leu Gln Val Pro Met Gly Ala Ala Ala Pro 
         715                 720                 725

 ctcccactgc cctgcacacc accacattgg acctgtgctg tcctgggagg tggtgttgga   2812

 ggccccatga agagcgccct ggactgctga gggtgggcca acagcccaga gctcaggaca   2872

 tttggctttg gggggaagga aactgaggcc cagagagggg caaccactgg ccaagggtca   2932

 cccagcaagt tttggctaag agcctggcct ccagccccag cagtgtggcc cagagcaggg   2992

 gccgactgcc aaagtaacca tcatccatat gggccgtgtg gtgatgctgg cccggaaggc   3052

 agaaagaggc agcatgggca ctgccaggga cagccacatc ctgctggtct gcagcgtggt   3112

 ccaccccgcc cctgcccagc ctgtctacac cgtgtgagct gaatcgtgac ttgcttccca   3172

 cctcctttct ctgtcctctc ctgaggttct gcctgcagcc cctaggaggt gggcctgccc   3232

 catcctagct ggactcatgg ttcctaaata accacgctca gaagctctgc taggacttac   3292

 cccagccact gagtggcagg cgcatgaga                                     3321




      <210> 144
      <211> 2451
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (265)..(1938)

      <400> 144
 gactactgta ctcccaggca gaaacccacg gctgaagccc acgatgccca tgtgtaactt     60

 ggttattaca cacacgtttg gagcccagtg tgcagacccg cagcgcagag gaggcggcgg    120

 aacaccccgg gttggtcggg tttccaaggg ctgacccgag ctccagcact ttttccgcgc    180

 ctgatttttc agagctcttc agaaaccagg ctgctttcag gaacattgct gtggattccc    240

 agggcctatt ccactagaag caag   atg gct gaa ctc aat act cat gtg aat     291
                              Met Ala Glu Leu Asn Thr His Val Asn
                                1               5

 gtc aag gaa aag atc tat gca gtt aga tca gtt gtt ccc aac aaa agc      339
 Val Lys Glu Lys Ile Tyr Ala Val Arg Ser Val Val Pro Asn Lys Ser
  10                  15                  20                  25

 aat aat gaa ata gtc ctg gtg ctc caa cag ttt gat ttt aat gtg gat      387
 Asn Asn Glu Ile Val Leu Val Leu Gln Gln Phe Asp Phe Asn Val Asp
                  30                  35                  40

 aaa gcc gtg caa gcc ttt gtg gat ggc agt gca att caa gtt cta aaa      435
 Lys Ala Val Gln Ala Phe Val Asp Gly Ser Ala Ile Gln Val Leu Lys
              45                  50                  55

 gaa tgg aat atg aca gga aaa aag aag aac aat aaa aga aaa aga agc      483
 Glu Trp Asn Met Thr Gly Lys Lys Lys Asn Asn Lys Arg Lys Arg Ser
          60                  65                  70

 aag tcc aag cag cat caa ggc aac aaa gat gct aaa gac aag gtg gag      531
 Lys Ser Lys Gln His Gln Gly Asn Lys Asp Ala Lys Asp Lys Val Glu
      75                  80                  85

 agg cct gag gca ggg ccc ctg cag ccg cag cca cca cag att caa aac      579
 Arg Pro Glu Ala Gly Pro Leu Gln Pro Gln Pro Pro Gln Ile Gln Asn
  90                  95                 100                 105

 ggc ccc atg aat ggc tgc gag aag gac agc tcg tcc aca gat tct gct      627
 Gly Pro Met Asn Gly Cys Glu Lys Asp Ser Ser Ser Thr Asp Ser Ala
                 110                 115                 120

 aac gaa aaa cca gcc ctt atc cct cgt gag aaa aag atc tcg ata ctt      675
 Asn Glu Lys Pro Ala Leu Ile Pro Arg Glu Lys Lys Ile Ser Ile Leu
             125                 130                 135

 gag gaa cct tca aag gca ctt cgt ggg gtc aca gaa ggc aac aga cta      723
 Glu Glu Pro Ser Lys Ala Leu Arg Gly Val Thr Glu Gly Asn Arg Leu
         140                 145                 150

 ctg caa cag aaa cta tcc tta gat ggg aac ccc aaa cct ata cat gga      771
 Leu Gln Gln Lys Leu Ser Leu Asp Gly Asn Pro Lys Pro Ile His Gly
     155                 160                 165

 aca aca gag agg tca gat ggc cta cag tgg tca gct gag cag cct tgt      819
 Thr Thr Glu Arg Ser Asp Gly Leu Gln Trp Ser Ala Glu Gln Pro Cys
 170                 175                 180                 185

 aac cca agc aag cct aag gca aaa aca tct cct gtt aag tcc aat acc      867
 Asn Pro Ser Lys Pro Lys Ala Lys Thr Ser Pro Val Lys Ser Asn Thr
                 190                 195                 200

 cct gca gct cat ctt gaa ata aag cca gat gag ttg gca aag aaa aga      915
 Pro Ala Ala His Leu Glu Ile Lys Pro Asp Glu Leu Ala Lys Lys Arg
             205                 210                 215

 ggc cca aat att gag aaa tca gtg aag gat ttg caa cgc tgc acc gtt      963
 Gly Pro Asn Ile Glu Lys Ser Val Lys Asp Leu Gln Arg Cys Thr Val
         220                 225                 230

 tct cta act aga tat cgc gtc atg att aag gaa gaa gtg gat agt tcc     1011
 Ser Leu Thr Arg Tyr Arg Val Met Ile Lys Glu Glu Val Asp Ser Ser
     235                 240                 245

 gtg aag aag atc aaa gct gcc ttt gct gaa tta cac aac tgc atc att     1059
 Val Lys Lys Ile Lys Ala Ala Phe Ala Glu Leu His Asn Cys Ile Ile
 250                 255                 260                 265

 gac aaa gaa gtt tca tta atg gca gaa atg gat aaa gtt aaa gaa gaa     1107
 Asp Lys Glu Val Ser Leu Met Ala Glu Met Asp Lys Val Lys Glu Glu
                 270                 275                 280

 gcc atg gaa atc ctg act gct cgt cag aag aaa gca gaa gaa cta aag     1155
 Ala Met Glu Ile Leu Thr Ala Arg Gln Lys Lys Ala Glu Glu Leu Lys
             285                 290                 295

 aga ctc act gac ctt gcc agt cag atg gca gag atg cag ctg gcc gaa     1203
 Arg Leu Thr Asp Leu Ala Ser Gln Met Ala Glu Met Gln Leu Ala Glu
         300                 305                 310

 ctc agg gca gaa att aag cac ttt gtc agc gag cgt aaa tat gac gag     1251
 Leu Arg Ala Glu Ile Lys His Phe Val Ser Glu Arg Lys Tyr Asp Glu
     315                 320                 325

 gag ctc ggg aaa gct gcc cgg ttt tcc tgt gac atc gaa cag ctg aag     1299
 Glu Leu Gly Lys Ala Ala Arg Phe Ser Cys Asp Ile Glu Gln Leu Lys
 330                 335                 340                 345

 gcc caa atc atg ctc tgc gga gaa att aca cat cca aag aac aac tat     1347
 Ala Gln Ile Met Leu Cys Gly Glu Ile Thr His Pro Lys Asn Asn Tyr
                 350                 355                 360

 tcc tca aga act ccc tgc agc tcc ctg ctg cct ctg ctg aat gcg cac     1395
 Ser Ser Arg Thr Pro Cys Ser Ser Leu Leu Pro Leu Leu Asn Ala His
             365                 370                 375

 gca gca acc tct ggg aaa cag agt aac ttt tcc cga aaa tca tcc act     1443
 Ala Ala Thr Ser Gly Lys Gln Ser Asn Phe Ser Arg Lys Ser Ser Thr
         380                 385                 390

 cac aat aag ccc tct gaa ggc aaa gcg gca aac ccc aaa atg gtg agc     1491
 His Asn Lys Pro Ser Glu Gly Lys Ala Ala Asn Pro Lys Met Val Ser
     395                 400                 405

 agt ctc ccc agc acc gcc gac ccc tct cac cag acc atg ccg gcc aac     1539
 Ser Leu Pro Ser Thr Ala Asp Pro Ser His Gln Thr Met Pro Ala Asn
 410                 415                 420                 425

 aag cag aat gga tct tct aac caa aga cgg aga ttt aat cca cag tat     1587
 Lys Gln Asn Gly Ser Ser Asn Gln Arg Arg Arg Phe Asn Pro Gln Tyr
                 430                 435                 440

 cat aac aac agg cta aat ggg cct gcc aag tcg cag ggc agt ggg aat     1635
 His Asn Asn Arg Leu Asn Gly Pro Ala Lys Ser Gln Gly Ser Gly Asn
             445                 450                 455

 gaa gcc gag cca ctg gga aag ggc aac agc cgc cac gaa cac aga aga     1683
 Glu Ala Glu Pro Leu Gly Lys Gly Asn Ser Arg His Glu His Arg Arg
         460                 465                 470

 cag ccg cac aac ggc ttc cgg ccc aaa aac aaa ggc ggt gcc aaa aat     1731
 Gln Pro His Asn Gly Phe Arg Pro Lys Asn Lys Gly Gly Ala Lys Asn
     475                 480                 485

 caa gag gct tcc ttg ggg atg aag acc ccc gag gcc ccg gcc cat tct     1779
 Gln Glu Ala Ser Leu Gly Met Lys Thr Pro Glu Ala Pro Ala His Ser
 490                 495                 500                 505

 gaa aag ccc cgg cga agg cag cac gct gca gac acc tcg gag gcc agg     1827
 Glu Lys Pro Arg Arg Arg Gln His Ala Ala Asp Thr Ser Glu Ala Arg
                 510                 515                 520

 ccc ttc cgg ggt agt gtc ggt agg gtt tca cag tgc aat ctc tgc ccc     1875
 Pro Phe Arg Gly Ser Val Gly Arg Val Ser Gln Cys Asn Leu Cys Pro
             525                 530                 535

 acg aga ata gaa gtt tcc aca gat gca gca gtt ctc tca gtc ccg gct     1923
 Thr Arg Ile Glu Val Ser Thr Asp Ala Ala Val Leu Ser Val Pro Ala
         540                 545                 550

 gtg acg ttg gtg gcc tgagctagga ggaaaaagag cagttttcac tcagttttgg     1978
 Val Thr Leu Val Ala 
     555

 ttccctgccc gaggtgctga cccaattcgc tgccaaaaga gtgtcaatca gaatatacaa   2038

 atcccgtatg gttgtgtcat cctctcttaa tcatttttac taattctaat aatcagctct   2098

 agcttgcttc ataattttca tggctttgct tgatctgttg atgctttctc tcatcaagac   2158

 tttgcagcat tttagccagg cagtatttac tcattattag gaaaatcaag atgtggctga   2218

 agatcagagg ctcagttagc aacctgtgtt gtagcagtga tgtcagtcca ttgattgtct   2278

 ttagagagtt aatgttacaa aaaagaattc ttaataatca gacaaacatg atctgctgag   2338

 gacacatgcg cttttgtaga atttaacatc tggtgttttt ctgaaaaaat atatatacat   2398

 atattgcttt atttgaaaca aattaaaata tgctgcattt gaaaaaaaaa aaa          2451




      <210> 145
      <211> 2244
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (265)..(1731)

      <400> 145
 gactactgta ctcccaggca gaaacccacg gctgaagccc acgatgccca tgtgtaactt     60

 ggttattaca cacacgtttg gagcccagtg tgcagacccg cagcgcagag gaggcggcgg    120

 aacaccccgg gttggtcggg tttccaaggg ctgacccgag ctccagcact ttttccgcgc    180

 ctgatttttc agagctcttc agaaaccagg ctgctttcag gaacattgct gtggattccc    240

 agggcctatt ccactagaag caag   atg gct gaa ctc aat act cat gtg aat     291
                              Met Ala Glu Leu Asn Thr His Val Asn
                                1               5

 gtc aag gaa aag atc tat gca gtt aga tca gtt gtt ccc aac aaa agc      339
 Val Lys Glu Lys Ile Tyr Ala Val Arg Ser Val Val Pro Asn Lys Ser
  10                  15                  20                  25

 aat aat gaa ata gtc ctg gtg ctc caa cag ttt gat ttt aat gtg gat      387
 Asn Asn Glu Ile Val Leu Val Leu Gln Gln Phe Asp Phe Asn Val Asp
                  30                  35                  40

 aaa gcc gtg caa gcc ttt gtg gat ggc agt gca att caa gtt cta aaa      435
 Lys Ala Val Gln Ala Phe Val Asp Gly Ser Ala Ile Gln Val Leu Lys
              45                  50                  55

 gaa tgg aat atg aca gga aaa aag aag aac aat aaa aga aaa aga agc      483
 Glu Trp Asn Met Thr Gly Lys Lys Lys Asn Asn Lys Arg Lys Arg Ser
          60                  65                  70

 aag tcc aag cag cat caa ggc aac aaa gat gct aaa gac aag gtg gag      531
 Lys Ser Lys Gln His Gln Gly Asn Lys Asp Ala Lys Asp Lys Val Glu
      75                  80                  85

 agg cct gag gca ggg ccc ctg cag ccg cag cca cca cag att caa aac      579
 Arg Pro Glu Ala Gly Pro Leu Gln Pro Gln Pro Pro Gln Ile Gln Asn
  90                  95                 100                 105

 ggc ccc atg aat ggc tgc gag aag gac agc tcg tcc aca gat tct gct      627
 Gly Pro Met Asn Gly Cys Glu Lys Asp Ser Ser Ser Thr Asp Ser Ala
                 110                 115                 120

 aac gaa aaa cca gcc ctt atc cct cgt gag aaa aag atc tcg ata ctt      675
 Asn Glu Lys Pro Ala Leu Ile Pro Arg Glu Lys Lys Ile Ser Ile Leu
             125                 130                 135

 gag gaa cct tca aag gca ctt cgt ggg gtc aca ggc cca aat att gag      723
 Glu Glu Pro Ser Lys Ala Leu Arg Gly Val Thr Gly Pro Asn Ile Glu
         140                 145                 150

 aaa tca gtg aag gat ttg caa cgc tgc acc gtt tct cta act aga tat      771
 Lys Ser Val Lys Asp Leu Gln Arg Cys Thr Val Ser Leu Thr Arg Tyr
     155                 160                 165

 cgc gtc atg att aag gaa gaa gtg gat agt tcc gtg aag aag atc aaa      819
 Arg Val Met Ile Lys Glu Glu Val Asp Ser Ser Val Lys Lys Ile Lys
 170                 175                 180                 185

 gct gcc ttt gct gaa tta cac aac tgc atc att gac aaa gaa gtt tca      867
 Ala Ala Phe Ala Glu Leu His Asn Cys Ile Ile Asp Lys Glu Val Ser
                 190                 195                 200

 tta atg gca gaa atg gat aaa gtt aaa gaa gaa gcc atg gaa atc ctg      915
 Leu Met Ala Glu Met Asp Lys Val Lys Glu Glu Ala Met Glu Ile Leu
             205                 210                 215

 act gct cgt cag aag aaa gca gaa gaa cta aag aga ctc act gac ctt      963
 Thr Ala Arg Gln Lys Lys Ala Glu Glu Leu Lys Arg Leu Thr Asp Leu
         220                 225                 230

 gcc agt cag atg gca gag atg cag ctg gcc gaa ctc agg gca gaa att     1011
 Ala Ser Gln Met Ala Glu Met Gln Leu Ala Glu Leu Arg Ala Glu Ile
     235                 240                 245

 aag cac ttt gtc agc gag cgt aaa tat gac gag gag ctc ggg aaa gct     1059
 Lys His Phe Val Ser Glu Arg Lys Tyr Asp Glu Glu Leu Gly Lys Ala
 250                 255                 260                 265

 gcc cgg ttt tcc tgt gac atc gaa cag ctg aag gcc caa atc atg ctc     1107
 Ala Arg Phe Ser Cys Asp Ile Glu Gln Leu Lys Ala Gln Ile Met Leu
                 270                 275                 280

 tgc gga gaa att aca cat cca aag aac aac tat tcc tca aga act ccc     1155
 Cys Gly Glu Ile Thr His Pro Lys Asn Asn Tyr Ser Ser Arg Thr Pro
             285                 290                 295

 tgc agc tcc ctg ctg cct ctg ctg aat gcg cac gca gca acc tct ggg     1203
 Cys Ser Ser Leu Leu Pro Leu Leu Asn Ala His Ala Ala Thr Ser Gly
         300                 305                 310

 aaa cag agt aac ttt tcc cga aaa tca tcc act cac aat aag ccc tct     1251
 Lys Gln Ser Asn Phe Ser Arg Lys Ser Ser Thr His Asn Lys Pro Ser
     315                 320                 325

 gaa ggc aaa gcg gca aac ccc aaa atg gtg agc agt ctc ccc agc acc     1299
 Glu Gly Lys Ala Ala Asn Pro Lys Met Val Ser Ser Leu Pro Ser Thr
 330                 335                 340                 345

 gcc gac ccc tct cac cag acc atg ccg gcc aac aag cag aat gga tct     1347
 Ala Asp Pro Ser His Gln Thr Met Pro Ala Asn Lys Gln Asn Gly Ser
                 350                 355                 360

 tct aac caa aga cgg aga ttt aat cca cag tat cat aac aac agg cta     1395
 Ser Asn Gln Arg Arg Arg Phe Asn Pro Gln Tyr His Asn Asn Arg Leu
             365                 370                 375

 aat ggg cct gcc aag tcg cag ggc agt ggg aat gaa gcc gag cca ctg     1443
 Asn Gly Pro Ala Lys Ser Gln Gly Ser Gly Asn Glu Ala Glu Pro Leu
         380                 385                 390

 gga aag ggc aac agc cgc cac gaa cac aga aga cag ccg cac aac ggc     1491
 Gly Lys Gly Asn Ser Arg His Glu His Arg Arg Gln Pro His Asn Gly
     395                 400                 405

 ttc cgg ccc aaa aac aaa ggc ggt gcc aaa aat caa gag gct tcc ttg     1539
 Phe Arg Pro Lys Asn Lys Gly Gly Ala Lys Asn Gln Glu Ala Ser Leu
 410                 415                 420                 425

 ggg atg aag acc ccc gag gcc ccg gcc cat tct gaa aag ccc cgg cga     1587
 Gly Met Lys Thr Pro Glu Ala Pro Ala His Ser Glu Lys Pro Arg Arg
                 430                 435                 440

 agg cag cac gct gca gac acc tcg gag gcc agg ccc ttc cgg ggt agt     1635
 Arg Gln His Ala Ala Asp Thr Ser Glu Ala Arg Pro Phe Arg Gly Ser
             445                 450                 455

 gtc ggt agg gtt tca cag tgc aat ctc tgc ccc acg aga ata gaa gtt     1683
 Val Gly Arg Val Ser Gln Cys Asn Leu Cys Pro Thr Arg Ile Glu Val
         460                 465                 470

 tcc aca gat gca gca gtt ctc tca gtc ccg gct gtg acg ttg gtg gcc     1731
 Ser Thr Asp Ala Ala Val Leu Ser Val Pro Ala Val Thr Leu Val Ala 
     475                 480                 485

 tgagctagga ggaaaaagag cagttttcac tcagttttgg ttccctgccc gaggtgctga   1791

 cccaattcgc tgccaaaaga gtgtcaatca gaatatacaa atcccgtatg gttgtgtcat   1851

 cctctcttaa tcatttttac taattctaat aatcagctct agcttgcttc ataattttca   1911

 tggctttgct tgatctgttg atgctttctc tcatcaagac tttgcagcat tttagccagg   1971

 cagtatttac tcattattag gaaaatcaag atgtggctga agatcagagg ctcagttagc   2031

 aacctgtgtt gtagcagtga tgtcagtcca ttgattgtct ttagagagtt aatgttacaa   2091

 aaaagaattc ttaataatca gacaaacatg atctgctgag gacacatgcg cttttgtaga   2151

 atttaacatc tggtgttttt ctgaaaaaat atatatacat atattgcttt atttgaaaca   2211

 aattaaaata tgctgcattt gaaaaaaaaa aaa                                2244




      <210> 146
      <211> 711
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (245)..(589)

      <400> 146
 tgaagggagg tagtaaccaa ggttccgtgg ctcctgagac ttcttggggc ctgatttgat     60

 taacccagga agagtctcag acctcatgaa gtactgccag gtctggcagc acttggccaa    120

 agcgggcagg tctgtgttga ggttgcttta tgcagactaa caaagggatc attctgctgt    180

 gtacctgtcc ctattctaga ccctggtggg cagcagtggg accattctga ccacaatgcc    240

 tgta atg atg ggg caa gag aaa gtg ccc att aag cag gta cct ggg gga     289
      Met Met Gly Gln Glu Lys Val Pro Ile Lys Gln Val Pro Gly Gly
        1               5                  10                  15

 gtc aag cag ctt gag ccc ccc aaa gaa gga gaa agg cgg aca acc cat      337
 Val Lys Gln Leu Glu Pro Pro Lys Glu Gly Glu Arg Arg Thr Thr His
                  20                  25                  30

 aat atc att gag aaa cga tat cgc tcc tcc atc aat gac aaa atc atc      385
 Asn Ile Ile Glu Lys Arg Tyr Arg Ser Ser Ile Asn Asp Lys Ile Ile
              35                  40                  45

 gaa ttg aaa gac ctg gtc atg ggg aca gac gcc aag atg cac aag tct      433
 Glu Leu Lys Asp Leu Val Met Gly Thr Asp Ala Lys Met His Lys Ser
          50                  55                  60

 ggc gtt ctg agg aag gcc att gat tac acc aga tgc ctg aaa ggc ctc      481
 Gly Val Leu Arg Lys Ala Ile Asp Tyr Thr Arg Cys Leu Lys Gly Leu
      65                  70                  75

 cat ggc ttt cct gcc ctt cct ggt tcc gga cag ctg ggg aaa ggc cac      529
 His Gly Phe Pro Ala Leu Pro Gly Ser Gly Gln Leu Gly Lys Gly His
  80                  85                  90                  95

 agc agc tcc tct gct gcc ctg cag tct ttg ggg gcg ggg agg gct gga      577
 Ser Ser Ser Ser Ala Ala Leu Gln Ser Leu Gly Ala Gly Arg Ala Gly
                 100                 105                 110

 cat gtg gaa ccc tga tgcagccgca gcgtcaagga cgaggaaggg gtgggaaggg      632
 His Val Glu Pro 
             115

 atggtacgtg gaggggaatg ggtggtggga ccagggaccc aatgctaata aagactggac    692

 tgtgcttcaa aaaaaaaaa                                                 711




      <210> 147
      <211> 3519
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (312)..(3044)

      <400> 147
 agtgcaagac gggcgggctg ctgagggcgc cccgcgggtc tggtctgggc cggggaactc     60

 cgggacggcg ccgcagcagg gctacggatc tctcggcccc tgcccttcaa atcacctcta    120

 ggcacaggtt attcagcttc tcaaggctgg aaaagcgaag gaagtttcct acaatgcact    180

 agcctcacac ataatctcag aggatgggga caatccagag gtgggagaag ctcgggaagt    240

 ctttgactta cctgttgtaa agccttcttg ggtgattctg tccgttcagt gtggaactct    300

 tctgccagta a atg gtt ttt ctc cag aat cat gtc aga ttt ttt ttg gaa     350
              Met Val Phe Leu Gln Asn His Val Arg Phe Phe Leu Glu
                1               5                  10

 tca ctg cct gcc ttt ctc agg gtg ttg ata caa gct gga gct ctt tgt      398
 Ser Leu Pro Ala Phe Leu Arg Val Leu Ile Gln Ala Gly Ala Leu Cys
      15                  20                  25

 tgg agt ctt cca gag ctc tcc caa gga gag gta ggg aag gga gct tgt      446
 Trp Ser Leu Pro Glu Leu Ser Gln Gly Glu Val Gly Lys Gly Ala Cys
  30                  35                  40                  45

 cca gca gaa gtt ggg aag cac aga gat cat ctg cct tct tct gac ccg      494
 Pro Ala Glu Val Gly Lys His Arg Asp His Leu Pro Ser Ser Asp Pro
                  50                  55                  60

 gta ttg atg cag gct gag gcc tct gtt gta atg tgc tgg gtg tca tct      542
 Val Leu Met Gln Ala Glu Ala Ser Val Val Met Cys Trp Val Ser Ser
              65                  70                  75

 gaa gac aga agt gcc ctg tgg gct ttg gtt acg ttc tat ggg gga gat      590
 Glu Asp Arg Ser Ala Leu Trp Ala Leu Val Thr Phe Tyr Gly Gly Asp
          80                  85                  90

 tgc cag cta acc ctc aat aag aaa tgc acg cat ttg att gtt cca gag      638
 Cys Gln Leu Thr Leu Asn Lys Lys Cys Thr His Leu Ile Val Pro Glu
      95                 100                 105

 cca aag ggg ggg aaa tac gaa tgt gct tta aag cga gca agt att aaa      686
 Pro Lys Gly Gly Lys Tyr Glu Cys Ala Leu Lys Arg Ala Ser Ile Lys
 110                 115                 120                 125

 att gtg act cct gac tgg gtt ctg gat tgc gta tca gag aaa acc aaa      734
 Ile Val Thr Pro Asp Trp Val Leu Asp Cys Val Ser Glu Lys Thr Lys
                 130                 135                 140

 aag gac gaa gca ttt tat cat cct cgt ctg att att tat gaa gag gaa      782
 Lys Asp Glu Ala Phe Tyr His Pro Arg Leu Ile Ile Tyr Glu Glu Glu
             145                 150                 155

 gaa gag gaa gag gaa gag gag gag gaa gta gaa aat gag gaa caa gat      830
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Glu Asn Glu Glu Gln Asp
         160                 165                 170

 tct cag aat gag ggt agt aca gat gag aag tca agc cct gcc agc tct      878
 Ser Gln Asn Glu Gly Ser Thr Asp Glu Lys Ser Ser Pro Ala Ser Ser
     175                 180                 185

 caa gaa ggg tct cct tca ggt gac cag cag ttt tca cct aaa tcc aac      926
 Gln Glu Gly Ser Pro Ser Gly Asp Gln Gln Phe Ser Pro Lys Ser Asn
 190                 195                 200                 205

 act gaa aaa tct aaa ggg gaa tta atg ttt gat gat tct tca gat tca      974
 Thr Glu Lys Ser Lys Gly Glu Leu Met Phe Asp Asp Ser Ser Asp Ser
                 210                 215                 220

 tca ccg gaa aaa cag gag aga aat tta aac tgg acc ccg gcc gaa gtc     1022
 Ser Pro Glu Lys Gln Glu Arg Asn Leu Asn Trp Thr Pro Ala Glu Val
             225                 230                 235

 cca cag tta gct gca gca aaa cgc agg ctg cct cag gga aag gag cct     1070
 Pro Gln Leu Ala Ala Ala Lys Arg Arg Leu Pro Gln Gly Lys Glu Pro
         240                 245                 250

 ggg ttg att aac ttg tgt gcc aat gtc cca ccc gtc cca ggt aac att     1118
 Gly Leu Ile Asn Leu Cys Ala Asn Val Pro Pro Val Pro Gly Asn Ile
     255                 260                 265

 ttg ccc cct gag gtc cgg ggt aat tta atg gct gct gga caa aac ctc     1166
 Leu Pro Pro Glu Val Arg Gly Asn Leu Met Ala Ala Gly Gln Asn Leu
 270                 275                 280                 285

 caa agt tct gaa aga tca gaa atg ata gct acc tgg agt cca gct gta     1214
 Gln Ser Ser Glu Arg Ser Glu Met Ile Ala Thr Trp Ser Pro Ala Val
                 290                 295                 300

 cgg aca ctg agg aat att act aat aat gct gac att cag cag atg aac     1262
 Arg Thr Leu Arg Asn Ile Thr Asn Asn Ala Asp Ile Gln Gln Met Asn
             305                 310                 315

 cgg cca tca aat gta gca cat atc tta cag act ctt tca gca cct acg     1310
 Arg Pro Ser Asn Val Ala His Ile Leu Gln Thr Leu Ser Ala Pro Thr
         320                 325                 330

 aaa aat tta gaa cag cag gtg aat cac agc cag cag gga cat aca aat     1358
 Lys Asn Leu Glu Gln Gln Val Asn His Ser Gln Gln Gly His Thr Asn
     335                 340                 345

 gcc aat gca gtg ctg ttt agc caa gtg aaa gtg act cca gag aca cac     1406
 Ala Asn Ala Val Leu Phe Ser Gln Val Lys Val Thr Pro Glu Thr His
 350                 355                 360                 365

 atg cta cag cag cag cag cag gcc cag cag cag cag cag cag cac ccg     1454
 Met Leu Gln Gln Gln Gln Gln Ala Gln Gln Gln Gln Gln Gln His Pro
                 370                 375                 380

 gtt tta cac ctt cag ccc cag cag ata atg cag ctc cag cag cag cag     1502
 Val Leu His Leu Gln Pro Gln Gln Ile Met Gln Leu Gln Gln Gln Gln
             385                 390                 395

 cag cag cag atc tct cag caa cct tac ccc cag cag ccg ccg cat cca     1550
 Gln Gln Gln Ile Ser Gln Gln Pro Tyr Pro Gln Gln Pro Pro His Pro
         400                 405                 410

 ttt tca cag cag cag cag cag caa cag cag cca cca cca tcg cct cag     1598
 Phe Ser Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Ser Pro Gln
     415                 420                 425

 cag cat cag ctt ttt gga cat gat cca gca gtg gag att cca gaa gaa     1646
 Gln His Gln Leu Phe Gly His Asp Pro Ala Val Glu Ile Pro Glu Glu
 430                 435                 440                 445

 ggc ttc tta ttg gga tgt gtg ttt gca att gcg gat tat cca gag cag     1694
 Gly Phe Leu Leu Gly Cys Val Phe Ala Ile Ala Asp Tyr Pro Glu Gln
                 450                 455                 460

 atg tct gat aag caa ctg ctg gcc acc tgg aaa agg ata atc cag gca     1742
 Met Ser Asp Lys Gln Leu Leu Ala Thr Trp Lys Arg Ile Ile Gln Ala
             465                 470                 475

 cat ggc ggc act gtt gac ccc acc ttc acg agt cga tgc acg cac ctt     1790
 His Gly Gly Thr Val Asp Pro Thr Phe Thr Ser Arg Cys Thr His Leu
         480                 485                 490

 ctc tgt gag agt caa gtc agc agc gcg tat gca cag gca ata aga gaa     1838
 Leu Cys Glu Ser Gln Val Ser Ser Ala Tyr Ala Gln Ala Ile Arg Glu
     495                 500                 505

 aga aag aga tgt gtt act gca cac tgg tta aac aca gtc tta aaa aaa     1886
 Arg Lys Arg Cys Val Thr Ala His Trp Leu Asn Thr Val Leu Lys Lys
 510                 515                 520                 525

 aaa aaa atg gta ccg ccg cac cga gcc ctt cac ttc cca gtg gcc ttc     1934
 Lys Lys Met Val Pro Pro His Arg Ala Leu His Phe Pro Val Ala Phe
                 530                 535                 540

 cca cca gga gga aag cca tgt tca cag cat att att tct gtg act gga     1982
 Pro Pro Gly Gly Lys Pro Cys Ser Gln His Ile Ile Ser Val Thr Gly
             545                 550                 555

 ttt gtt gat agt gac aga gat gac cta aaa tta atg gct tat ttg gca     2030
 Phe Val Asp Ser Asp Arg Asp Asp Leu Lys Leu Met Ala Tyr Leu Ala
         560                 565                 570

 ggt gcc aaa tat acg ggt tat cta tgc cgc agc aac aca gtc ctc atc     2078
 Gly Ala Lys Tyr Thr Gly Tyr Leu Cys Arg Ser Asn Thr Val Leu Ile
     575                 580                 585

 tgt aaa gaa cca act ggt tta aag tat gaa aaa gcc aaa gag tgg agg     2126
 Cys Lys Glu Pro Thr Gly Leu Lys Tyr Glu Lys Ala Lys Glu Trp Arg
 590                 595                 600                 605

 ata ccc tgt gtc aac gcc cag tgg ctt ggc gac att ctt ctg gga aac     2174
 Ile Pro Cys Val Asn Ala Gln Trp Leu Gly Asp Ile Leu Leu Gly Asn
                 610                 615                 620

 ttt gag gca ctg agg cag att cag tat agt cgc tac acg gca ttc agt     2222
 Phe Glu Ala Leu Arg Gln Ile Gln Tyr Ser Arg Tyr Thr Ala Phe Ser
             625                 630                 635

 ctg cag gat cca ttt gcc cct acc cag cat tta gtt tta aat ctt tta     2270
 Leu Gln Asp Pro Phe Ala Pro Thr Gln His Leu Val Leu Asn Leu Leu
         640                 645                 650

 gat gct tgg aga gtt ccc tta aaa gtg tct gca gag ttg ttg atg agt     2318
 Asp Ala Trp Arg Val Pro Leu Lys Val Ser Ala Glu Leu Leu Met Ser
     655                 660                 665

 ata aga cta cct ccc aaa ctg aaa cag aat gaa gta gct aat gtc cag     2366
 Ile Arg Leu Pro Pro Lys Leu Lys Gln Asn Glu Val Ala Asn Val Gln
 670                 675                 680                 685

 cct tct tcc caa aga gcc aga att gaa gac gta cca cct ccc act aaa     2414
 Pro Ser Ser Gln Arg Ala Arg Ile Glu Asp Val Pro Pro Pro Thr Lys
                 690                 695                 700

 aag cta act cca gaa ttg acc cct ttt gtg ctt ttc act gga ttc gag     2462
 Lys Leu Thr Pro Glu Leu Thr Pro Phe Val Leu Phe Thr Gly Phe Glu
             705                 710                 715

 cct gtc cag gtt caa cag tat att aag aag ctc tac att ctt ggt gga     2510
 Pro Val Gln Val Gln Gln Tyr Ile Lys Lys Leu Tyr Ile Leu Gly Gly
         720                 725                 730

 gag gtt gcg gag tct gca cag aag tgc aca cac ctc att gcc agc aaa     2558
 Glu Val Ala Glu Ser Ala Gln Lys Cys Thr His Leu Ile Ala Ser Lys
     735                 740                 745

 gtg act cgc acc gtg aag ttc ctg acg gcg att tct gtc gtg aag cac     2606
 Val Thr Arg Thr Val Lys Phe Leu Thr Ala Ile Ser Val Val Lys His
 750                 755                 760                 765

 ata gtg acg cca gag tgg ctg gaa gaa tgc ttc agg tgt cag aag ttc     2654
 Ile Val Thr Pro Glu Trp Leu Glu Glu Cys Phe Arg Cys Gln Lys Phe
                 770                 775                 780

 att gat gag cag aac tac att ctc cga gat gct gag gca gaa gta ctt     2702
 Ile Asp Glu Gln Asn Tyr Ile Leu Arg Asp Ala Glu Ala Glu Val Leu
             785                 790                 795

 ttc tct ttc agc ttg gaa gaa tcc tta aaa cgg gca cac gtt tct cca     2750
 Phe Ser Phe Ser Leu Glu Glu Ser Leu Lys Arg Ala His Val Ser Pro
         800                 805                 810

 ctc ttt aag gca aaa tat ttt tac atc aca cct gga atc tgc cca agt     2798
 Leu Phe Lys Ala Lys Tyr Phe Tyr Ile Thr Pro Gly Ile Cys Pro Ser
     815                 820                 825

 ctt tcc act atg aag gca atc gta gag tgt gca gga gga aag gtg tta     2846
 Leu Ser Thr Met Lys Ala Ile Val Glu Cys Ala Gly Gly Lys Val Leu
 830                 835                 840                 845

 tcc aag cag cca tct ttc cgg aag ctc atg gag cac aag cag aac tcg     2894
 Ser Lys Gln Pro Ser Phe Arg Lys Leu Met Glu His Lys Gln Asn Ser
                 850                 855                 860

 agt ttg tcg gaa ata att tta ata tcc tgt gaa aat gac ctt cat tta     2942
 Ser Leu Ser Glu Ile Ile Leu Ile Ser Cys Glu Asn Asp Leu His Leu
             865                 870                 875

 tgc cga gaa tat ttt gcc aga ggc ata gat gtt cac aat gca gag ttc     2990
 Cys Arg Glu Tyr Phe Ala Arg Gly Ile Asp Val His Asn Ala Glu Phe
         880                 885                 890

 gtt ctg act gga gtg ctc act caa acg ctg gac tat gaa tca tat aag     3038
 Val Leu Thr Gly Val Leu Thr Gln Thr Leu Asp Tyr Glu Ser Tyr Lys
     895                 900                 905

 ttt aac tgatggcgtc taggctgccg tgcatgtcga ctcctgcggt gcggggctgg      3094
 Phe Asn 
 910

 ctgtctggct ggcgaggagc tgctgcgctt ccttcacatg ctcttgtttt ccagctgctt   3154

 tcctggggga tcagactgtg aagcaggaag acagatataa taaatatact gcatcttttt   3214

 aagatgtgca attttattct gaggaaacat aaattatgtt ttgtattata tgactttaag   3274

 agcccacatt aggttttatg attcatttgc caggttttta aatgttttca caaaactgtt   3334

 acgggacttc aactagaaat aaaatggtgt aaataaagac cttgctatct ctaaattatg   3394

 gatgttaaag atttgaaatg ttttgtactt tgattatttt tatttcttat actctgtttt   3454

 cttttatatt gatatcttgc ccacatttta aataaatgta cttttgaact tagaaaaaaa   3514

 aaaaa                                                               3519




      <210> 148
      <211> 865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (385)..(597)

      <220>
      <221> misc_feature
      <222> (1)...(865)
      <223> n = a,t,c or g

      <400> 148
 ggcacgaggt tagttttcct tctaacggac aggaccctca gctgcaggtc tgttggaata     60

 ccctgcagtg tgaggtgtca gtgtgcccct gctggggggt gcctcccagt taggctgctc    120

 gggggtcagg ggtcagggac ccacttgagg aggcagtctg cccgttctca gatctccagc    180

 tgcgtgctgg gagaaccact gctctcttca aagctgtcag acagggacat ttaagtctgc    240

 agaggttact gctgtctttt tgtttgtctg tgccctgccc ccagaggtgg agcctacaga    300

 ggcaggcagg cctccttgag ctgtggtggg ctccacccag ttcgagcttc ccggctgctt    360

 tgtttaccta agcaagcctg ggca   atg gcg ggc gcc cct ccc cca gcc tcg     411
                              Met Ala Gly Ala Pro Pro Pro Ala Ser
                                1               5

 ttg ccg cct tgc agt ttg atc tca gac tgc tgt gct agc aat cag cga      459
 Leu Pro Pro Cys Ser Leu Ile Ser Asp Cys Cys Ala Ser Asn Gln Arg
  10                  15                  20                  25

 gat tcc gtg ggc gta gga ccc tct gag cca ggt gtg gga tat agt ctc      507
 Asp Ser Val Gly Val Gly Pro Ser Glu Pro Gly Val Gly Tyr Ser Leu
                  30                  35                  40

 gtg gtg cgc cgt ttc tta agc cgg tct gaa aag cgc aat att cgg gtg      555
 Val Val Arg Arg Phe Leu Ser Arg Ser Glu Lys Arg Asn Ile Arg Val
              45                  50                  55

 gga gtg acc cga ttt tcc agg tgc gtc cgt cac ccc ttt ctt tgactcg      604
 Gly Val Thr Arg Phe Ser Arg Cys Val Arg His Pro Phe Leu 
          60                  65                  70

 gaaagggaac tccctgaccc cttgcgcttc ccaagcgagg caatgcctcg ccctgcttcg    664

 gctcgcgcac ggtgcgcgca cccactgacc tgcgcccagt gtctggcact ccctagtgag    724

 atgaacccgg tacctcagat ggaaatgcag aaatcacccg tcttctgcgg cgctcacgct    784

 gggagctgta gactagagct gttcctattt ggctcgtgcc gtttgcagca gntcgtcagt    844

 tnnctcaatt nncnggcccc c                                              865




      <210> 149
      <211> 1183
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(801)

      <400> 149
 acaatgacta atcaaactaa cctcaaaaca aatgataacc atacacaaca ctaaaggacg     60

 aacctgatct cttatactag tatccttaat catttttatt gccacaacta acctcctcgg    120

 actcctgcct tactcattta caccaaccac ccaactatct ataaacctag ccatggccat    180

 cccctt   atg agc ggg cgc agt ggt tat agg ctt tcg ctc ttg ctg ttg     228
          Met Ser Gly Arg Ser Gly Tyr Arg Leu Ser Leu Leu Leu Leu
            1               5                  10

 gcg gcg ctg ggc agc ggc cgc gcg gag cgc gac tgc cga gtg agc agc      276
 Ala Ala Leu Gly Ser Gly Arg Ala Glu Arg Asp Cys Arg Val Ser Ser
  15                  20                  25                  30

 ttc cga gtc aag gag aac ttc gac aag gct cgc ttc tct ggg acc tgg      324
 Phe Arg Val Lys Glu Asn Phe Asp Lys Ala Arg Phe Ser Gly Thr Trp
                  35                  40                  45

 tac gcc atg gcc aag aag gac ccc gag ggc ctc ttt ctg cag gac aac      372
 Tyr Ala Met Ala Lys Lys Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn
              50                  55                  60

 atc gtc gcg gag ttc tcc gtg gac gag acc ggc cag atg agc gcc aca      420
 Ile Val Ala Glu Phe Ser Val Asp Glu Thr Gly Gln Met Ser Ala Thr
          65                  70                  75

 gcc aag ggc cga gtc cgt ctt ttg aat aac tgg gac gtg tgc gca gac      468
 Ala Lys Gly Arg Val Arg Leu Leu Asn Asn Trp Asp Val Cys Ala Asp
      80                  85                  90

 atg gtg ggc acc ttc aca gac acc gag gac cct gcc aag ttc aag atg      516
 Met Val Gly Thr Phe Thr Asp Thr Glu Asp Pro Ala Lys Phe Lys Met
  95                 100                 105                 110

 aag tac tgg ggc gta gcc tcc ttt ctc cag aaa gga aat gat gac cac      564
 Lys Tyr Trp Gly Val Ala Ser Phe Leu Gln Lys Gly Asn Asp Asp His
                 115                 120                 125

 tgg atc gtc gac aca gac tac gac acg tat gcc gtg cag tac tcc tgc      612
 Trp Ile Val Asp Thr Asp Tyr Asp Thr Tyr Ala Val Gln Tyr Ser Cys
             130                 135                 140

 cgc ctc ctg aac ctc gat ggc acc tgt gct gac agc tac tcc ttc gtg      660
 Arg Leu Leu Asn Leu Asp Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val
         145                 150                 155

 ttt tcc cgg gac ccc aac ggc ctg ccc cca gaa gcg cag aag att gta      708
 Phe Ser Arg Asp Pro Asn Gly Leu Pro Pro Glu Ala Gln Lys Ile Val
     160                 165                 170

 agg cag cgg cag gag gag ctg tgc ctg gcc agg cag tac agg ctg atc      756
 Arg Gln Arg Gln Glu Glu Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile
 175                 180                 185                 190

 gtc cac aac ggt tac tgc gat ggc aga tca gaa aga aac ctt ttg tag      804
 Val His Asn Gly Tyr Cys Asp Gly Arg Ser Glu Arg Asn Leu Leu 
                 195                 200                 205

 caatatcaag aatctagttt catctgagaa cttctgatta gctctcagtc ttcagctcta    864

 tttatcttag gagtttaatt tgcccttctc tccccatctt ccctcagttc ccataaaacc    924

 ttcattacac ataaagatac acgtgggggt cagtgaatct gcttgccttt cctgaaagtt    984

 tctggggctt aagattccag actctgattc attaaactat agtcaccgtg tctggaaaaa   1044

 ataaaaaaaa atctctgccg attcttggct gaaggccaat tcctattgtg gtgcataaat   1104

 cgcatatgtc atagtgtttc tgggtgatgt attccgtaaa ttcaacacaa cagccgaacc   1164

 tagtgaaggc tggtgccta                                                1183




      <210> 150
      <211> 4211
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (26)..(2536)

      <400> 150
 cagctcggtc gcccccaccg gcccc  atg gca gcc ccc ggc gcc cca gct gag      52
                              Met Ala Ala Pro Gly Ala Pro Ala Glu
                                1               5

 tac ggc tac atc cgg acc gtc ctg ggc cag cag atc ctg gga caa ctg      100
 Tyr Gly Tyr Ile Arg Thr Val Leu Gly Gln Gln Ile Leu Gly Gln Leu
  10                  15                  20                  25

 gac agc tcc agc ctg gcg ctg ccc tcc gag gcc aag ctg aag ctg gcg      148
 Asp Ser Ser Ser Leu Ala Leu Pro Ser Glu Ala Lys Leu Lys Leu Ala
                  30                  35                  40

 ggg agc agc ggc cgc ggc ggc cag aca gtc aag agc ctg cgg atc cag      196
 Gly Ser Ser Gly Arg Gly Gly Gln Thr Val Lys Ser Leu Arg Ile Gln
              45                  50                  55

 gag cag gtg cag cag acc ctc gcc cgg aag ggc cgc agc tcc gtg ggc      244
 Glu Gln Val Gln Gln Thr Leu Ala Arg Lys Gly Arg Ser Ser Val Gly
          60                  65                  70

 aac gga aat ctt cac cga acc agc agt gtt cct gag tat gtc tac aac      292
 Asn Gly Asn Leu His Arg Thr Ser Ser Val Pro Glu Tyr Val Tyr Asn
      75                  80                  85

 cta cac ttg gtt gaa aat gat ttt gtt gga ggc cgt tcc cct gtt cct      340
 Leu His Leu Val Glu Asn Asp Phe Val Gly Gly Arg Ser Pro Val Pro
  90                  95                 100                 105

 aaa acc tat gac atg cta aag gct ggc aca att gcc act tat gaa ggt      388
 Lys Thr Tyr Asp Met Leu Lys Ala Gly Thr Ile Ala Thr Tyr Glu Gly
                 110                 115                 120

 cgc tgg gga aga gga aca gca cag tac agc tcc cag aag tcc gtg gaa      436
 Arg Trp Gly Arg Gly Thr Ala Gln Tyr Ser Ser Gln Lys Ser Val Glu
             125                 130                 135

 gaa agg tcc ttg agg cat cct ctg agg aga ctg gag att tct cct gac      484
 Glu Arg Ser Leu Arg His Pro Leu Arg Arg Leu Glu Ile Ser Pro Asp
         140                 145                 150

 agc agc ccg gag agg gct cac tac acg cac agc gat tac cag tac agc      532
 Ser Ser Pro Glu Arg Ala His Tyr Thr His Ser Asp Tyr Gln Tyr Ser
     155                 160                 165

 cag aga agc cag gct ggg cac acc ctg cac cac caa gaa agc agg cgg      580
 Gln Arg Ser Gln Ala Gly His Thr Leu His His Gln Glu Ser Arg Arg
 170                 175                 180                 185

 gcc gcc ctc cta gtg cca ccg aga tat gct cgt tcc gag atc gtg ggg      628
 Ala Ala Leu Leu Val Pro Pro Arg Tyr Ala Arg Ser Glu Ile Val Gly
                 190                 195                 200

 gtc agc cgt gct ggc acc aca agc agg cag cgc cac ttt gac aca tac      676
 Val Ser Arg Ala Gly Thr Thr Ser Arg Gln Arg His Phe Asp Thr Tyr
             205                 210                 215

 cac aga cag tac cag cat ggc tct gtt agc gac acc gtt ttt gac agc      724
 His Arg Gln Tyr Gln His Gly Ser Val Ser Asp Thr Val Phe Asp Ser
         220                 225                 230

 atc cct gcc aac ccg gcc ctg ctc acg tac ccc agg cca ggg acc agc      772
 Ile Pro Ala Asn Pro Ala Leu Leu Thr Tyr Pro Arg Pro Gly Thr Ser
     235                 240                 245

 cgc agc atg ggc aac ctc ttg gag aag gag aac tac ctg acg gca ggg      820
 Arg Ser Met Gly Asn Leu Leu Glu Lys Glu Asn Tyr Leu Thr Ala Gly
 250                 255                 260                 265

 ctc act gtc ggg cag gtc agg ccg ctg gtg ccc ctg cag ccc gtc act      868
 Leu Thr Val Gly Gln Val Arg Pro Leu Val Pro Leu Gln Pro Val Thr
                 270                 275                 280

 cag aac agg gct tcc agg tcc tcc tgg cat cag agc tcc ttc cac agc      916
 Gln Asn Arg Ala Ser Arg Ser Ser Trp His Gln Ser Ser Phe His Ser
             285                 290                 295

 acc cgc acg ctg agg gaa gct ggg ccc agt gtc gcc gtg gat tcc agc      964
 Thr Arg Thr Leu Arg Glu Ala Gly Pro Ser Val Ala Val Asp Ser Ser
         300                 305                 310

 ggg agg aga gcg cac ttg act gtc ggc cag gcg gcc gca ggg gga agt     1012
 Gly Arg Arg Ala His Leu Thr Val Gly Gln Ala Ala Ala Gly Gly Ser
     315                 320                 325

 ggg aat ctg ctc act gag aga agc act ttc act gac tcc cag ctg ggg     1060
 Gly Asn Leu Leu Thr Glu Arg Ser Thr Phe Thr Asp Ser Gln Leu Gly
 330                 335                 340                 345

 aat gca gac atg gag atg act ctg gag cga gca gtg agt atg ctc gag     1108
 Asn Ala Asp Met Glu Met Thr Leu Glu Arg Ala Val Ser Met Leu Glu
                 350                 355                 360

 gca gac cac atg ccg cca tcc agg att tct gct gca gct act ttc ata     1156
 Ala Asp His Met Pro Pro Ser Arg Ile Ser Ala Ala Ala Thr Phe Ile
             365                 370                 375

 cag cac gag tgc ttc cag aaa tct gaa gct cgg aag agg gtt aac cag     1204
 Gln His Glu Cys Phe Gln Lys Ser Glu Ala Arg Lys Arg Val Asn Gln
         380                 385                 390

 ctt cgt ggc atc ctc aag ctt ctg cag ctc cta aaa gtt cag aat gaa     1252
 Leu Arg Gly Ile Leu Lys Leu Leu Gln Leu Leu Lys Val Gln Asn Glu
     395                 400                 405

 gac gtt cag cga gct gtg tgt ggg gcc ttg aga aac tta gta ttt gaa     1300
 Asp Val Gln Arg Ala Val Cys Gly Ala Leu Arg Asn Leu Val Phe Glu
 410                 415                 420                 425

 gac aat gac aac aaa ttg gag gtg gct gaa cta aat ggg gta cct cgg     1348
 Asp Asn Asp Asn Lys Leu Glu Val Ala Glu Leu Asn Gly Val Pro Arg
                 430                 435                 440

 ctg ctc cag gtg ctg aag caa acc aga gac ttg gag act aaa aaa caa     1396
 Leu Leu Gln Val Leu Lys Gln Thr Arg Asp Leu Glu Thr Lys Lys Gln
             445                 450                 455

 ata aca ggt ttg ctg tgg aat ttg tca tct aat gac aaa ctc aag aat     1444
 Ile Thr Gly Leu Leu Trp Asn Leu Ser Ser Asn Asp Lys Leu Lys Asn
         460                 465                 470

 ctc atg ata aca gaa gca ttg ctt acg ctg acg gag aat atc atc atc     1492
 Leu Met Ile Thr Glu Ala Leu Leu Thr Leu Thr Glu Asn Ile Ile Ile
     475                 480                 485

 ccc ttt tct ggg tgg cct gaa gga gac tac cca aaa gca aat ggt ttg     1540
 Pro Phe Ser Gly Trp Pro Glu Gly Asp Tyr Pro Lys Ala Asn Gly Leu
 490                 495                 500                 505

 ctc gat ttt gac ata ttc tac aac gtc act gga tgc cta aga aac atg     1588
 Leu Asp Phe Asp Ile Phe Tyr Asn Val Thr Gly Cys Leu Arg Asn Met
                 510                 515                 520

 agt tct gct ggc gct gat ggg aga aaa gcg atg aga aga tgt gac gga     1636
 Ser Ser Ala Gly Ala Asp Gly Arg Lys Ala Met Arg Arg Cys Asp Gly
             525                 530                 535

 ctc att gac tca ctg gtc cat tat gtc aga gga acc att gca gat tac     1684
 Leu Ile Asp Ser Leu Val His Tyr Val Arg Gly Thr Ile Ala Asp Tyr
         540                 545                 550

 cag cca gat gac aag gcc acg gag aat tgt gtg tgc att ctt cat aac     1732
 Gln Pro Asp Asp Lys Ala Thr Glu Asn Cys Val Cys Ile Leu His Asn
     555                 560                 565

 ctc tcc tac cag ctg gag gca gag ctc cca gag aaa tat tcc cag aat     1780
 Leu Ser Tyr Gln Leu Glu Ala Glu Leu Pro Glu Lys Tyr Ser Gln Asn
 570                 575                 580                 585

 atc tat att caa aac cgg aat atc cag act gac aac aac aaa agt att     1828
 Ile Tyr Ile Gln Asn Arg Asn Ile Gln Thr Asp Asn Asn Lys Ser Ile
                 590                 595                 600

 gga tgt ttt ggc agt cga agc agg aaa gta aaa gag caa tac cag gac     1876
 Gly Cys Phe Gly Ser Arg Ser Arg Lys Val Lys Glu Gln Tyr Gln Asp
             605                 610                 615

 gtg ccg atg ccg gag gaa aag agc aac ccc aag ggc gtg gag tgg ctg     1924
 Val Pro Met Pro Glu Glu Lys Ser Asn Pro Lys Gly Val Glu Trp Leu
         620                 625                 630

 tgg cat tcc att gtt ata agg atg tat ctg tcc ttg atc gcc aaa agt     1972
 Trp His Ser Ile Val Ile Arg Met Tyr Leu Ser Leu Ile Ala Lys Ser
     635                 640                 645

 gtc cgc aac tac aca caa gaa gca tcc tta gga gct ctg cag aac ctc     2020
 Val Arg Asn Tyr Thr Gln Glu Ala Ser Leu Gly Ala Leu Gln Asn Leu
 650                 655                 660                 665

 acg gcc gga agt gga cca atg ccg aca tca gtg gct cag aca gtt gtc     2068
 Thr Ala Gly Ser Gly Pro Met Pro Thr Ser Val Ala Gln Thr Val Val
                 670                 675                 680

 cag aag gaa agt ggc ctg cag cac acc cga aag atg ctg cat gtt ggt     2116
 Gln Lys Glu Ser Gly Leu Gln His Thr Arg Lys Met Leu His Val Gly
             685                 690                 695

 gac cca agt gtg aaa aag aca gcc atc tcg ctg ctg agg aat ctg tcc     2164
 Asp Pro Ser Val Lys Lys Thr Ala Ile Ser Leu Leu Arg Asn Leu Ser
         700                 705                 710

 cgg aat ctt tct ctg cag aat gaa att gcc aaa gaa act ctc cct gat     2212
 Arg Asn Leu Ser Leu Gln Asn Glu Ile Ala Lys Glu Thr Leu Pro Asp
     715                 720                 725

 ttg gtt tcc atc att cct gac aca gtc ccg agt act gac ctt ctc att     2260
 Leu Val Ser Ile Ile Pro Asp Thr Val Pro Ser Thr Asp Leu Leu Ile
 730                 735                 740                 745

 gaa act aca gcc tct gcc tgt tac aca ttg aac aac ata atc caa aac     2308
 Glu Thr Thr Ala Ser Ala Cys Tyr Thr Leu Asn Asn Ile Ile Gln Asn
                 750                 755                 760

 agt tac cag aat gca cgc gac ctt cta aac acc ggg ggc atc cag aaa     2356
 Ser Tyr Gln Asn Ala Arg Asp Leu Leu Asn Thr Gly Gly Ile Gln Lys
             765                 770                 775

 att atg gcc att agt gca ggc gat gcc tat gcc tcc aac aaa gca agt     2404
 Ile Met Ala Ile Ser Ala Gly Asp Ala Tyr Ala Ser Asn Lys Ala Ser
         780                 785                 790

 aaa gct gct tcc gtc ctt ctg tat tct ctg tgg gca cac acg gaa ctg     2452
 Lys Ala Ala Ser Val Leu Leu Tyr Ser Leu Trp Ala His Thr Glu Leu
     795                 800                 805

 cat cat gcc tac aag aag gct cag ttt aag aag aca gat ttt gtc aac     2500
 His His Ala Tyr Lys Lys Ala Gln Phe Lys Lys Thr Asp Phe Val Asn
 810                 815                 820                 825

 agc cgg act gcc aaa gcc tac cac tcc ctt aaa gac tgag gaaaatgaca     2550
 Ser Arg Thr Ala Lys Ala Tyr His Ser Leu Lys Asp 
                 830                 835

 aagtattctc ggctgcaaaa atccccaaag gaaaacacct atttttctac tacccagccc   2610

 aagaaacctc aaaagcatgc cttgtttcta tccttctcta tttccgtggt cccctgaatc   2670

 cagaaaacaa atagaacata attttatgag tcttccagaa gacctttgca agtttgccac   2730

 cagtagatac cggccacagg ctcgacaaat agtggtcttt gttattaggg cttatggtag   2790

 atggcttcct ggaatcaaaa tgtgaattca tgtggaaggg acattaatcc aataaataag   2850

 gaaagaagct gttgcattac tgggatttta aaagtttgat ttacatttat attccttttc   2910

 tggttcccat gttttgtcac tcatgtgcac attgcttcgc cattgggcct ccagtgtatt   2970

 gttctgcagt gttgaaacag aatggaaatg acaagaaata tctgcagtta tccaggagaa   3030

 agtataatgg caaaattatt ggtttctttc tttactttgt gcttgttttt atccccttgg   3090

 ttgtttttct ctgattttta aataaactta agaaatttag attacagagt atgcatgact   3150

 gtaagaaaaa gaaattgaga ggaagtgatc atagcaaatt aaagaagtct tttcctccca   3210

 gaacttaaag taaaataaaa aataaataaa taaataaaat cttttccaca gagaaaggca   3270

 actgtgatga taaaatttaa cgttccccca aacactgagt caatgagatt tttctcagga   3330

 gatactttac ctataacaac gccgttaaat ccaaatctct tctaaacgat ggcattctat   3390

 gtaatgcctt tcctggactt ttttggccac tgccctggac tagtgaaaga atggactcta   3450

 tctttatctg caagaggaac taaggccttc tatcagactg cctggccagc ctggggcact   3510

 gaaaatacgg ctcatgttaa tgagttacat tatcagccag cccagccttg cccaccattt   3570

 aagaaatatc acagagccac tagatctcat atgatcttct tcaagccatt attttaactc   3630

 aagaaaactc tagagaagaa aagtgaagaa gtcatgttga agaagatgta agaatgtgtc   3690

 aagaccatcc agaaatgata tgagaaatac tgatatttta aatggttgac atcatccagc   3750

 gaaatgaatc tacattaaat gttgttttaa ctgcgctatg attaaaacca ttcatataga   3810

 gttagtcttt acaactacta ttctgttatt ttttttttta atctgacaac atttgtccta   3870

 agtaagataa gcaaaaaaat tcttcaactc cttttggcaa gaaaactgta acagaaaata   3930

 aattttgaat gtgtacttaa gtctttatta tatttgaagc aatttttttt caattttaaa   3990

 agctgaatga agacaactta ggttgctaac ctagttcaaa atgaaattat ttagatacca   4050

 atttttaaaa tactggagag aatttatatg tctttttcca gagttctgat tataagcatt   4110

 tggagtgcat ttattcctcc agataataaa tgtgtgttca gaactttttg tgttttttaa   4170

 ggcattaata aagccttcga taatattaaa tacaaaaaaa a                       4211




      <210> 151
      <211> 1045
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(719)

      <400> 151
 ctgcaccata ttccagaaca actgagcaaa caagagaggt acaccgacaa   atg gca      56
                                                          Met Ala
                                                            1

 gcg acg cac aca ccc cct ctg gcg tca ccg ggc atg gcg cgc atc tgc      104
 Ala Thr His Thr Pro Pro Leu Ala Ser Pro Gly Met Ala Arg Ile Cys
           5                  10                  15

 ctt tac ggg gat tta caa cga ttt ggt cgc cgc atc gac ctt cgt gtg      152
 Leu Tyr Gly Asp Leu Gln Arg Phe Gly Arg Arg Ile Asp Leu Arg Val
      20                  25                  30

 aaa acg ggg gct gaa gcc atc cgg gca ctg gcc aca cag ctc ccg gcg      200
 Lys Thr Gly Ala Glu Ala Ile Arg Ala Leu Ala Thr Gln Leu Pro Ala
  35                  40                  45                  50

 ttt cgt cag aaa ctg agc gac ggc tgg tat cag gta cgg att gcc ggg      248
 Phe Arg Gln Lys Leu Ser Asp Gly Trp Tyr Gln Val Arg Ile Ala Gly
                  55                  60                  65

 cgg gac gtc agc acg tcc ggg tta acg gcg cag tta cat gag act ctg      296
 Arg Asp Val Ser Thr Ser Gly Leu Thr Ala Gln Leu His Glu Thr Leu
              70                  75                  80

 cct gat ggc gct gta att cat att gtt ccc aga gtc gcc ggg gcc aag      344
 Pro Asp Gly Ala Val Ile His Ile Val Pro Arg Val Ala Gly Ala Lys
          85                  90                  95

 tca ggt ggc gta ttc cag att gtc ctg ggg gct gcc gcc att gcc gga      392
 Ser Gly Gly Val Phe Gln Ile Val Leu Gly Ala Ala Ala Ile Ala Gly
     100                 105                 110

 tca ttc ttt acc gcc gga gcc acc ctt gca gca tgg ggg gca gcc att      440
 Ser Phe Phe Thr Ala Gly Ala Thr Leu Ala Ala Trp Gly Ala Ala Ile
 115                 120                 125                 130

 ggg gcc ggt ggt atg acc ggc atc ctg ttt tct ctc ggt gcc agt atg      488
 Gly Ala Gly Gly Met Thr Gly Ile Leu Phe Ser Leu Gly Ala Ser Met
                 135                 140                 145

 gtg ctc ggt ggt gtg gcg cag atg ctg gca ccg aaa gcc aga act ccc      536
 Val Leu Gly Gly Val Ala Gln Met Leu Ala Pro Lys Ala Arg Thr Pro
             150                 155                 160

 cgt ata cag aca acg gat aac ggt aag cag aac acc tat ttc tcc tca      584
 Arg Ile Gln Thr Thr Asp Asn Gly Lys Gln Asn Thr Tyr Phe Ser Ser
         165                 170                 175

 ctg gat aac atg gtt gcc cag ggc aat gtt ctg cct gtt ctg tac ggg      632
 Leu Asp Asn Met Val Ala Gln Gly Asn Val Leu Pro Val Leu Tyr Gly
     180                 185                 190

 gaa atg cgc gtg ggg tca cgc gtg gtt tct cag gag atc agc acg gca      680
 Glu Met Arg Val Gly Ser Arg Val Val Ser Gln Glu Ile Ser Thr Ala
 195                 200                 205                 210

 gac gaa ggg gac ggt ggt cag gtt gtg gtg att ggt cgc tgatgcaaaa       729
 Asp Glu Gly Asp Gly Gly Gln Val Val Val Ile Gly Arg 
                 215                 220

 tgttttatgt gaaaccgcct gcgggcggtt ttgtcattta tggagcgtga ggaatgggta    789

 aaggaagcag taaggggcat accccgcgcg aagcgaagga caacctgaag tccacgcagt    849

 tgctgagtgt gatcgatgcc atcagcgaag ggccgattga aggtccggtg gatggcttaa    909

 aaagcgtgct gctgaacagt acgccggtgc tggacactga ggggaatacc aacatatccg    969

 gtgtcacggt ggcgttcccg gctgttgagc aggatcatac tcccccccaa aggatttgga   1029

 tcctcccccc ccccac                                                   1045




      <210> 152
      <211> 714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(668)

      <400> 152
 aggaggagaa attaggt   atg gat gac ttg act aag ttg gta cag gaa cag      50
                      Met Asp Asp Leu Thr Lys Leu Val Gln Glu Gln
                        1               5                  10

 aaa cct aaa ggc agt cag cga agt cgg aaa aga ggc cat acg gct tca       98
 Lys Pro Lys Gly Ser Gln Arg Ser Arg Lys Arg Gly His Thr Ala Ser
              15                  20                  25

 gaa tct gat gaa cag cag tgg cct gag gaa aag agg ctc aaa gaa gat      146
 Glu Ser Asp Glu Gln Gln Trp Pro Glu Glu Lys Arg Leu Lys Glu Asp
          30                  35                  40

 ata tta gaa aat gaa gat gaa cag aat agt ccg cca aaa aag ggt aaa      194
 Ile Leu Glu Asn Glu Asp Glu Gln Asn Ser Pro Pro Lys Lys Gly Lys
      45                  50                  55

 aga ggc cga cca cca aaa cct ctt ggt gga ggt aca cca aaa gaa gag      242
 Arg Gly Arg Pro Pro Lys Pro Leu Gly Gly Gly Thr Pro Lys Glu Glu
  60                  65                  70                  75

 cca aca atg aaa act tct aaa aaa gga agc aaa aaa aaa tct gga cct      290
 Pro Thr Met Lys Thr Ser Lys Lys Gly Ser Lys Lys Lys Ser Gly Pro
                  80                  85                  90

 cca gca cca gag gag gag gaa gaa gaa gaa aga caa agt gga aat acg      338
 Pro Ala Pro Glu Glu Glu Glu Glu Glu Glu Arg Gln Ser Gly Asn Thr
              95                 100                 105

 gaa cag aag tcc aaa agc aaa cag cac cga gtg tca agg aga gca cag      386
 Glu Gln Lys Ser Lys Ser Lys Gln His Arg Val Ser Arg Arg Ala Gln
         110                 115                 120

 cag aga gca gaa tct cct gaa tct agt gca att gaa tcc aca cag tcc      434
 Gln Arg Ala Glu Ser Pro Glu Ser Ser Ala Ile Glu Ser Thr Gln Ser
     125                 130                 135

 aca cca cag aaa gga cga gga aga cca tca aaa acg cca tca cca tca      482
 Thr Pro Gln Lys Gly Arg Gly Arg Pro Ser Lys Thr Pro Ser Pro Ser
 140                 145                 150                 155

 caa cca aaa aaa aat gtc cgt gta gga cgc tcc aaa caa gca gct act      530
 Gln Pro Lys Lys Asn Val Arg Val Gly Arg Ser Lys Gln Ala Ala Thr
                 160                 165                 170

 aag gaa aat gat tca agt gaa gaa gta gat gtg ttt cag ggt agc tct      578
 Lys Glu Asn Asp Ser Ser Glu Glu Val Asp Val Phe Gln Gly Ser Ser
             175                 180                 185

 cct gtc gat gat att cca cag gaa gaa aca gag gag gag gaa gtt tct      626
 Pro Val Asp Asp Ile Pro Gln Glu Glu Thr Glu Glu Glu Glu Val Ser
         190                 195                 200

 aca gta aat gta cgg cgg cga agt gct aaa agg gaa cgg cga tgaacaa      675
 Thr Val Asn Val Arg Arg Arg Ser Ala Lys Arg Glu Arg Arg 
     205                 210                 215

 atgtaattaa taactttctc tgtgaaagct ttggaaaaa                           714




      <210> 153
      <211> 1563
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (209)..(1324)

      <400> 153
 agatcgagcg aggagcccaa gagcgagcgc gcagcacgaa gctcgagccg cctccgccgc     60

 gcgaccccac ctcggccgcc gccgcctgcg ccgcgagatc cgccccggcc tccccgagag    120

 cgagccccgg ccgccgcgac caccagccgc gctaaccgcc gaccaaccgc caccgaggcg    180

 cctgagcgag agcagaggag gaggaggc   atg agt gag gcg ggc gag gcc acc     232
                                  Met Ser Glu Ala Gly Glu Ala Thr
                                    1               5

 acc acc acc acc acc acc ctc ccg cag gct ccg acg gag gcg gcc gcc      280
 Thr Thr Thr Thr Thr Thr Leu Pro Gln Ala Pro Thr Glu Ala Ala Ala
      10                  15                  20

 gcg gct ccc cag gac ccc gcg ccc aag agc ccg gtg ggc agc ggt gcg      328
 Ala Ala Pro Gln Asp Pro Ala Pro Lys Ser Pro Val Gly Ser Gly Ala
  25                  30                  35                  40

 ccc cag gcc gcg gcc ccg gcg ccc gcc gcc cac gtc gca gga aac ccc      376
 Pro Gln Ala Ala Ala Pro Ala Pro Ala Ala His Val Ala Gly Asn Pro
                  45                  50                  55

 ggt ggg gac gcg gcc ccc gca gcc acg ggc acc gcg gcc gcc gcc tct      424
 Gly Gly Asp Ala Ala Pro Ala Ala Thr Gly Thr Ala Ala Ala Ala Ser
              60                  65                  70

 tta gcc acc gcc gcc ggc agc gaa gac gcg gag aaa aaa gtt ctc gcc      472
 Leu Ala Thr Ala Ala Gly Ser Glu Asp Ala Glu Lys Lys Val Leu Ala
          75                  80                  85

 acc aaa gtc ctt ggc act gtc aaa tgg ttc aac gtc aga aat gga tat      520
 Thr Lys Val Leu Gly Thr Val Lys Trp Phe Asn Val Arg Asn Gly Tyr
      90                  95                 100

 gga ttt ata aat cga aat gac acc aaa gaa gat gta ttt gta cat cag      568
 Gly Phe Ile Asn Arg Asn Asp Thr Lys Glu Asp Val Phe Val His Gln
 105                 110                 115                 120

 act gcc atc aag aag aat aac cca cgg aaa tat ctg cgc agt gta gga      616
 Thr Ala Ile Lys Lys Asn Asn Pro Arg Lys Tyr Leu Arg Ser Val Gly
                 125                 130                 135

 gat gga gaa act gta gag ttt gat gtg gtt gaa gga gag aag ggt gca      664
 Asp Gly Glu Thr Val Glu Phe Asp Val Val Glu Gly Glu Lys Gly Ala
             140                 145                 150

 gaa gct gcc aat gtg act ggc ccg gat gga gtt cct gtg gaa ggg agt      712
 Glu Ala Ala Asn Val Thr Gly Pro Asp Gly Val Pro Val Glu Gly Ser
         155                 160                 165

 cgt tac gct gca gat cgg cgc cgt tac aga cgt ggc tac tat gga agg      760
 Arg Tyr Ala Ala Asp Arg Arg Arg Tyr Arg Arg Gly Tyr Tyr Gly Arg
     170                 175                 180

 cgc cgt ggc cct ccc cgg aat tac gct ggg gag gag gag gag gaa ggg      808
 Arg Arg Gly Pro Pro Arg Asn Tyr Ala Gly Glu Glu Glu Glu Glu Gly
 185                 190                 195                 200

 agc ggc agc agt gaa gga ttt gac ccc cct gcc act gat agg cag ttc      856
 Ser Gly Ser Ser Glu Gly Phe Asp Pro Pro Ala Thr Asp Arg Gln Phe
                 205                 210                 215

 tct ggg gcc cgg aat cag ctg cgc cgc ccc cag tat cgc cct cag tac      904
 Ser Gly Ala Arg Asn Gln Leu Arg Arg Pro Gln Tyr Arg Pro Gln Tyr
             220                 225                 230

 cgg cag cgg cgg ttc ccg cct tac cac gtg gga cag acc ttt gac cgt      952
 Arg Gln Arg Arg Phe Pro Pro Tyr His Val Gly Gln Thr Phe Asp Arg
         235                 240                 245

 cgc tca cgg gtc tta ccc cat ccc aac aga ata cag gct ggt gag att     1000
 Arg Ser Arg Val Leu Pro His Pro Asn Arg Ile Gln Ala Gly Glu Ile
     250                 255                 260

 gga gag atg aag gat gga gtc cca gag gga gca caa ctt cag gga ccg     1048
 Gly Glu Met Lys Asp Gly Val Pro Glu Gly Ala Gln Leu Gln Gly Pro
 265                 270                 275                 280

 gtt cat cga aat cca act tac cgc cca agg tac cgt agc agg gga cct     1096
 Val His Arg Asn Pro Thr Tyr Arg Pro Arg Tyr Arg Ser Arg Gly Pro
                 285                 290                 295

 cct cgc cca cga cct gcc cca gca gtt gga gag gct gaa gat aaa gaa     1144
 Pro Arg Pro Arg Pro Ala Pro Ala Val Gly Glu Ala Glu Asp Lys Glu
             300                 305                 310

 aat cag caa gcc acc agt ggt cca aac cag ccg tct gtt cgc cgt gga     1192
 Asn Gln Gln Ala Thr Ser Gly Pro Asn Gln Pro Ser Val Arg Arg Gly
         315                 320                 325

 tac cgg cgt ccc tac aat tac cgg cgt cgc ccg cgt cct cct aac gct     1240
 Tyr Arg Arg Pro Tyr Asn Tyr Arg Arg Arg Pro Arg Pro Pro Asn Ala
     330                 335                 340

 cct tca caa gat ggc aaa gag gcc aag gca ggt gaa gca cca act gag     1288
 Pro Ser Gln Asp Gly Lys Glu Ala Lys Ala Gly Glu Ala Pro Thr Glu
 345                 350                 355                 360

 aac cct gct cca ccc acc cag cag agc agt gct gag taac accaggctcc     1338
 Asn Pro Ala Pro Pro Thr Gln Gln Ser Ser Ala Glu 
                 365                 370

 tcaggcacct tcaccatcgg caggtgacct aaagaattaa tgaccattca gaaataaagc   1398

 aaaaagcagg ccacaacctt aaccaacacc aaagaaacat ccaagcaata aagtggaaga   1458

 ctaaccaaga tttggacatt ggaatgttta ctgttattct ttaagaaaca actacaaaaa   1518

 gaaaatgtca acaaattttt ccagcaagct gagaacctgg aattc                   1563




      <210> 154
      <211> 1174
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (209)..(1117)

      <400> 154
 agatcgagcg aggagcccaa gagcgagcgc gcagcacgaa gctcgagccg cctccgccgc     60

 gcgaccccac ctcggccgcc gccgcctgcg ccgcgagatc cgccccggcc tccccgagag    120

 cgagccccgg ccgccgcgac caccagccgc gctaaccgcc gaccaaccgc caccgaggcg    180

 cctgagcgag agcagaggag gaggaggc   atg agt gag gcg ggc gag gcc acc     232
                                  Met Ser Glu Ala Gly Glu Ala Thr
                                    1               5

 acc acc acc acc acc acc ctc ccg cag gct ccg acg gag gcg gcc gcc      280
 Thr Thr Thr Thr Thr Thr Leu Pro Gln Ala Pro Thr Glu Ala Ala Ala
      10                  15                  20

 gcg gct ccc cag gac ccc gcg ccc aag agc ccg gtg ggc agc ggt gcg      328
 Ala Ala Pro Gln Asp Pro Ala Pro Lys Ser Pro Val Gly Ser Gly Ala
  25                  30                  35                  40

 ccc cag gcc gcg gcc ccg gcg ccc gcc gcc cac gtc gca gga aac ccc      376
 Pro Gln Ala Ala Ala Pro Ala Pro Ala Ala His Val Ala Gly Asn Pro
                  45                  50                  55

 ggt ggg gac gcg gcc ccc gca gcc acg ggc acc gcg gcc gcc gcc tct      424
 Gly Gly Asp Ala Ala Pro Ala Ala Thr Gly Thr Ala Ala Ala Ala Ser
              60                  65                  70

 tta gcc acc gcc gcc ggc agc gaa gac gcg gag aaa aaa gtt ctc gcc      472
 Leu Ala Thr Ala Ala Gly Ser Glu Asp Ala Glu Lys Lys Val Leu Ala
          75                  80                  85

 acc aaa gtc ctt ggc act gtc aaa tgg ttc aac gtc aga aat gga tat      520
 Thr Lys Val Leu Gly Thr Val Lys Trp Phe Asn Val Arg Asn Gly Tyr
      90                  95                 100

 gga ttt ata aat cga aat gac acc aaa gaa gat gta ttt gta cat cag      568
 Gly Phe Ile Asn Arg Asn Asp Thr Lys Glu Asp Val Phe Val His Gln
 105                 110                 115                 120

 act gcc atc aag aag aat aac cca cgg aaa tat ctg cgc agt gta gga      616
 Thr Ala Ile Lys Lys Asn Asn Pro Arg Lys Tyr Leu Arg Ser Val Gly
                 125                 130                 135

 gat gga gaa act gta gag ttt gat gtg gtt gaa gga gag aag ggt gca      664
 Asp Gly Glu Thr Val Glu Phe Asp Val Val Glu Gly Glu Lys Gly Ala
             140                 145                 150

 gaa gct gcc aat gtg act ggc ccg gat gga gtt cct gtg gaa ggg agt      712
 Glu Ala Ala Asn Val Thr Gly Pro Asp Gly Val Pro Val Glu Gly Ser
         155                 160                 165

 cgt tac gct gca gat cgg cgc cgt tac aga cgt ggc tac tat gga agg      760
 Arg Tyr Ala Ala Asp Arg Arg Arg Tyr Arg Arg Gly Tyr Tyr Gly Arg
     170                 175                 180

 cgc cgt ggc cct ccc cgg aat gct ggt gag att gga gag atg aag gat      808
 Arg Arg Gly Pro Pro Arg Asn Ala Gly Glu Ile Gly Glu Met Lys Asp
 185                 190                 195                 200

 gga gtc cca gag gga gca caa ctt cag gga ccg gtt cat cga aat cca      856
 Gly Val Pro Glu Gly Ala Gln Leu Gln Gly Pro Val His Arg Asn Pro
                 205                 210                 215

 act tac cgc cca agg tac cgt agc agg gga cct cct cgc cca cga cct      904
 Thr Tyr Arg Pro Arg Tyr Arg Ser Arg Gly Pro Pro Arg Pro Arg Pro
             220                 225                 230

 gcc cca gca gtt gga gag gct gaa gat aaa gaa aat cag caa gcc acc      952
 Ala Pro Ala Val Gly Glu Ala Glu Asp Lys Glu Asn Gln Gln Ala Thr
         235                 240                 245

 agt ggt cca aac cag ccg tct gtt cgc cgt gga tac cgg cgt ccc tac     1000
 Ser Gly Pro Asn Gln Pro Ser Val Arg Arg Gly Tyr Arg Arg Pro Tyr
     250                 255                 260

 aat tac cgg cgt cgc ccg cgt cct cct aac gct cct tca caa gat ggc     1048
 Asn Tyr Arg Arg Arg Pro Arg Pro Pro Asn Ala Pro Ser Gln Asp Gly
 265                 270                 275                 280

 aaa gag gcc aag gca ggt gaa gca cca act gag aac cct gct cca ccc     1096
 Lys Glu Ala Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala Pro Pro
                 285                 290                 295

 acc cag cag agc agt gct gag ta acaccaggct cctcaggcac cttcaccatc     1149
 Thr Gln Gln Ser Ser Ala Glu 
             300

 ggcaggtgac ctaaagaatt aatga                                         1174




      <210> 155
      <211> 787
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(392)

      <400> 155
 gggagagcgg cggggccgag agcgtgactc gcccgctccg cgctgcttcc cccgcgccgc     60

 ctccccgcgc cgctcgcgca gcc    atg tcc gag gag aag ccc aag gag ggt     110
                              Met Ser Glu Glu Lys Pro Lys Glu Gly
                                1               5

 gtg aag aca gag aat gac cac atc aac ctg aag gtg gcc ggg cag gac      158
 Val Lys Thr Glu Asn Asp His Ile Asn Leu Lys Val Ala Gly Gln Asp
  10                  15                  20                  25

 ggc tcc gtg gtg cag ttc aag atc aag agg cac acg ccg ctg agc aag      206
 Gly Ser Val Val Gln Phe Lys Ile Lys Arg His Thr Pro Leu Ser Lys
                  30                  35                  40

 ctg atg aag gcc tac tgc gag agg cag ggc ttg tca atg agg cag atc      254
 Leu Met Lys Ala Tyr Cys Glu Arg Gln Gly Leu Ser Met Arg Gln Ile
              45                  50                  55

 aga ttc agg ttc gac ggg cag cca atc aat gaa act gac act cca gca      302
 Arg Phe Arg Phe Asp Gly Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala
          60                  65                  70

 cag ctg gag atg gag gac gag gac acc atc gac gtg ttc cag cag cag      350
 Gln Leu Glu Met Glu Asp Glu Asp Thr Ile Asp Val Phe Gln Gln Gln
      75                  80                  85

 acg gga ggt gtg ccg gag agc agc ctg gca ggg cac agt ttc tagaggg      399
 Thr Gly Gly Val Pro Glu Ser Ser Leu Ala Gly His Ser Phe 
  90                  95                 100

 cccgtcccca gcccgggccg tccatcctcg cattgctgtt gaatggtgag cacgtgacca    459

 tgccgaccac aaaggtgtct gcggaaactc gaggacattc accacgatga ttttcctctc    519

 tttgatgtac ttcaagtgca actcaaaact atatctgcag ggatgaatct gtaacttaaa    579

 ttgggccaat cagaattgtt atctttgttc aggtaaaatg agttgcaaga tattgtgggt    639

 acttttgtgt gctcatttgt gttttccccc cctcctacaa cattttttta accccaaaat    699

 tatagcctga atgttcgctt ttagtctggc cagggatctg actcctgagt tggttgcctc    759

 tcccctgctc actccagtca catagaga                                       787




      <210> 156
      <211> 1541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(1255)

      <400> 156
 cagggcc  atg gcg gag gag cag ggc cgg gaa cgg gac tcg gtt ccc aag      49
          Met Ala Glu Glu Gln Gly Arg Glu Arg Asp Ser Val Pro Lys
            1               5                  10

 ccg tcg gtg ctg ttc ctc cac cca gac ctg ggc gtg ggc ggc gct gag       97
 Pro Ser Val Leu Phe Leu His Pro Asp Leu Gly Val Gly Gly Ala Glu
  15                  20                  25                  30

 cgg ctg gtg ttg gac gcg gcg ctg gcg ctg cag gcg cgc ggg tgt agc      145
 Arg Leu Val Leu Asp Ala Ala Leu Ala Leu Gln Ala Arg Gly Cys Ser
                  35                  40                  45

 gtg aag atc tgg aca gcg cac tac gac ccg ggc cac tgt ttc gcc gag      193
 Val Lys Ile Trp Thr Ala His Tyr Asp Pro Gly His Cys Phe Ala Glu
              50                  55                  60

 agc cgc gag cta ccg gtg cgc tgt gcc ggg gac tgg ctg ccg cga ggc      241
 Ser Arg Glu Leu Pro Val Arg Cys Ala Gly Asp Trp Leu Pro Arg Gly
          65                  70                  75

 ctg ggc tgg ggc ggc cgc ggc gcc gcc gtc tgc gcc tac gtg cgc atg      289
 Leu Gly Trp Gly Gly Arg Gly Ala Ala Val Cys Ala Tyr Val Arg Met
      80                  85                  90

 gtt ttc ctg gcg ctc tac gtg ctg ttc ctc gcc gac gag gag ttc gac      337
 Val Phe Leu Ala Leu Tyr Val Leu Phe Leu Ala Asp Glu Glu Phe Asp
  95                 100                 105                 110

 gtg gta gtg tgc gac cag gtg tct gcc tgt atc cca gtg ttc agg ctg      385
 Val Val Val Cys Asp Gln Val Ser Ala Cys Ile Pro Val Phe Arg Leu
                 115                 120                 125

 gct aga cgg cgg aag aag atc cta ttt tac tgt cac ttc cca gat ctg      433
 Ala Arg Arg Arg Lys Lys Ile Leu Phe Tyr Cys His Phe Pro Asp Leu
             130                 135                 140

 ctt ctc acc aag aga gat tct ttt ctt aaa cga cta tac agg gcc cca      481
 Leu Leu Thr Lys Arg Asp Ser Phe Leu Lys Arg Leu Tyr Arg Ala Pro
         145                 150                 155

 att gac tgg ata gag gaa tac acc aca ggc atg gca gac tgc atc tta      529
 Ile Asp Trp Ile Glu Glu Tyr Thr Thr Gly Met Ala Asp Cys Ile Leu
     160                 165                 170

 gtc aac agc cag ttc aca gct gct gtt ttt aag gaa aca ttc aag tcc      577
 Val Asn Ser Gln Phe Thr Ala Ala Val Phe Lys Glu Thr Phe Lys Ser
 175                 180                 185                 190

 ctg tct cac ata gac cct gat gtc ctc tat cca tct cta aat gtc acc      625
 Leu Ser His Ile Asp Pro Asp Val Leu Tyr Pro Ser Leu Asn Val Thr
                 195                 200                 205

 agc ttt gac tca gtt gtt cct gaa aag ctg gat gac cta gtc ccc aag      673
 Ser Phe Asp Ser Val Val Pro Glu Lys Leu Asp Asp Leu Val Pro Lys
             210                 215                 220

 ggg aaa aaa ttc ctg ctg ctc tcc atc aac aga tac gaa agg aag aaa      721
 Gly Lys Lys Phe Leu Leu Leu Ser Ile Asn Arg Tyr Glu Arg Lys Lys
         225                 230                 235

 aat ctg act ttg gca ctg gaa gcc cta gta cag ctg cgt gga aga ttg      769
 Asn Leu Thr Leu Ala Leu Glu Ala Leu Val Gln Leu Arg Gly Arg Leu
     240                 245                 250

 aca tcc caa gat tgg gag agg gtt cat ctg atc gtg gca ggt ggt tat      817
 Thr Ser Gln Asp Trp Glu Arg Val His Leu Ile Val Ala Gly Gly Tyr
 255                 260                 265                 270

 gac gag aga gtc ctg gag aat gtg gaa cat tat cag gaa ttg aag aaa      865
 Asp Glu Arg Val Leu Glu Asn Val Glu His Tyr Gln Glu Leu Lys Lys
                 275                 280                 285

 atg gtc caa cag tcc gac ctt ggc cag tat gtg acc ttc ttg agg tct      913
 Met Val Gln Gln Ser Asp Leu Gly Gln Tyr Val Thr Phe Leu Arg Ser
             290                 295                 300

 ttc tca gac aaa cag aaa atc tcc ctc ctc cac agc tgc acg tgt gtg      961
 Phe Ser Asp Lys Gln Lys Ile Ser Leu Leu His Ser Cys Thr Cys Val
         305                 310                 315

 ctt tac aca cca agc aat gag cac ttt ggc att gtc cct ctg gaa gcc     1009
 Leu Tyr Thr Pro Ser Asn Glu His Phe Gly Ile Val Pro Leu Glu Ala
     320                 325                 330

 atg tac atg cag tgc cca gtc att gct gtt aat tcg ggt gga ccc ttg     1057
 Met Tyr Met Gln Cys Pro Val Ile Ala Val Asn Ser Gly Gly Pro Leu
 335                 340                 345                 350

 gag tcc att gac cac agt gtc aca ggg ttt ctg tgt gag cct gac ccg     1105
 Glu Ser Ile Asp His Ser Val Thr Gly Phe Leu Cys Glu Pro Asp Pro
                 355                 360                 365

 gtg cac ttc tca gaa gca ata gaa aag ttc atc cgt gaa cct tcc tta     1153
 Val His Phe Ser Glu Ala Ile Glu Lys Phe Ile Arg Glu Pro Ser Leu
             370                 375                 380

 aaa gcc acc atg ggc ctg gct gga aga gcc aga gtg aag gaa aaa ttt     1201
 Lys Ala Thr Met Gly Leu Ala Gly Arg Ala Arg Val Lys Glu Lys Phe
         385                 390                 395

 tcc cct gaa gca ttt aca gaa cag ctc tac cga tat gtt acc aaa ctg     1249
 Ser Pro Glu Ala Phe Thr Glu Gln Leu Tyr Arg Tyr Val Thr Lys Leu
     400                 405                 410

 ctg gta taatcagatt gtttttaaga tctccattaa tgtcattttt atggattgta      1305
 Leu Val 
 415

 gacccagttt tgaaaccaaa aaagaaacct agaatctaat gcagaagaga tcttttaaaa   1365

 aataaacttg agtcttgaat gtgagccact ttcctatata ccacacctcc ctgtccactt   1425

 ttcagaaaaa ccatgtcttt tatgctataa tcattccaaa ttttgccagt gttaagttac   1485

 aaatgtggtg tcattccatg ttcagcagag tattttaatt atattttctc gggatt       1541




      <210> 157
      <211> 1106
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (513)..(1103)

      <400> 157
 ccgtgcggtg gaattcagcc cctcaagtgc tgggattaca ggcgtgagcc actgcacccg     60

 gttgatattt tttctaacaa tttttttttt ctcttccaca aagggtagta caaagttagg    120

 ggtgtgctca gctttctatg taacctaata tggggaaagc tgacctcgga agggggtaag    180

 atcaatctcc tctacgcctt tgccatggta cccagtgcca accactccac attaatcagc    240

 catgtgctgt tccaggggtc actgtcattc ggggacgtgg ctgtgggctt cacccggaaa    300

 gagtggcagc agctggacct ggagcaaagg accctgtacc aggatgtgat gctggagaac    360

 tacagccacc tgctctctgt gggctgaact gtctgcttgc ttggaaggcc cagctggctc    420

 agcacaaatc ctttgaccgt ttctccccaa gagggtgtca agtcagcaaa ccagctgtga    480

 tctccagttt ggagcagggg aaggagccat gg  atg gag gag gaa gag ata agg     533
                                      Met Glu Glu Glu Glu Ile Arg
                                        1               5

 acg tgg agc ttc cca gga gcg aat cca cgc gga ggt cac cag tgt gga      581
 Thr Trp Ser Phe Pro Gly Ala Asn Pro Arg Gly Gly His Gln Cys Gly
          10                  15                  20

 agt gct tta agc tgt gac gag gga gtt cct gca gct cag gga gcc agt      629
 Ser Ala Leu Ser Cys Asp Glu Gly Val Pro Ala Ala Gln Gly Ala Ser
      25                  30                  35

 agt gag aaa ccc cac gaa tgc acg aag tgt ggg aaa gcc ttg tgc tgc      677
 Ser Glu Lys Pro His Glu Cys Thr Lys Cys Gly Lys Ala Leu Cys Cys
  40                  45                  50                  55

 aga tcg gac ctc agg gta cat cac ggg gtc cac gcg ggg gag aag tcc      725
 Arg Ser Asp Leu Arg Val His His Gly Val His Ala Gly Glu Lys Ser
                  60                  65                  70

 tct gcg tgc agt gaa cgg ggg agt ggt ttc agg gag aag ctt tgc cct      773
 Ser Ala Cys Ser Glu Arg Gly Ser Gly Phe Arg Glu Lys Leu Cys Pro
              75                  80                  85

 gac aaa cag gga act cac aca aag gag aaa ccc gct aga gac agc aga      821
 Asp Lys Gln Gly Thr His Thr Lys Glu Lys Pro Ala Arg Asp Ser Arg
          90                  95                 100

 agt ggt aaa acg atc ttc cgg aag aca cgc ctg tgt gtc ccg ggc aca      869
 Ser Gly Lys Thr Ile Phe Arg Lys Thr Arg Leu Cys Val Pro Gly Thr
     105                 110                 115

 gtt cac gcc gga gcg aag cct tac aag tgt tgg gag tgt gag aaa acc      917
 Val His Ala Gly Ala Lys Pro Tyr Lys Cys Trp Glu Cys Glu Lys Thr
 120                 125                 130                 135

 tcc cac aag tcg cgc ctc atc gag cac ctt cgc tcc cac acg ggg gag      965
 Ser His Lys Ser Arg Leu Ile Glu His Leu Arg Ser His Thr Gly Glu
                 140                 145                 150

 aag ccc tgc ggc tgc agg gaa tgc gga aag gcc ttt ttc cag aag tca     1013
 Lys Pro Cys Gly Cys Arg Glu Cys Gly Lys Ala Phe Phe Gln Lys Ser
             155                 160                 165

 cac ctc atc ctg cgt cag agg act cac acg ggg gag aag ccc tgc gac     1061
 His Leu Ile Leu Arg Gln Arg Thr His Thr Gly Glu Lys Pro Cys Asp
         170                 175                 180

 tgc gcg gag tgc ggg aaa gct gct ccc agg act cct gcc tcc tga         1106
 Cys Ala Glu Cys Gly Lys Ala Ala Pro Arg Thr Pro Ala Ser 
     185                 190                 195





      <210> 158
      <211> 4164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2956)..(3978)

      <400> 158
 atgacatcgc tgcgcgaata tgccggttat cacggcggtg gcagcggatt tggagggcag     60

 ttgcggtcgt ggaacccacc gagtgaaagt gtggatgcag ccctgttgcc caactttacc    120

 cgtggcaatg cccgcgcaga cgatctggta cgcaataacg gctatgccgc caacgccatc    180

 cagctgcatc aggatcatat cgtcgggtct tttttccggc tcagtcatcg cccaagctgg    240

 cgctatctgg gcatcgggga ggaagaagcc cgtgcctttt cccgcgaggt tgaagcggca    300

 tggaaagagt ttgccgagga tgactgctgc tgcattgacg ttgagcgaaa acgcacgttt    360

 accatgatga ttcgggaagg tgtggccatg cacgccttta acggtgaact gttcgttcag    420

 gccacctggg ataccagttc gtcgcggctt ttccggacac agttccggat ggtcagcccg    480

 aagcgcatca gcaacccgaa caataccggc gacagccgga actgccgtgc cggtgtgcag    540

 attaatgaca gcggtgcggc gctgggatat tacgtcagcg aggacgggta tcctggctat    600

 atgccgcaga aatggacatg gataccccgt gagttacccg gcgggcgcgc ctcgttcatt    660

 cacgtttttg aacccgtgga ggacgggcag actcgcggtg caaatgtgtt ttacagcgtg    720

 atggagcaga taaagatgct cgacacgctg cagaacacgc agctgcagag cgccattgtg    780

 aaggcgatgt atgccgccac cattgagagt gagctggata cgcagtcagc gatggatttt    840

 attctgggcg cgaacagtca ggagcagcgg gaaaggctga ccggctggat tggtgaaatt    900

 gccgcgtatt acgccgcagc gccggtccgg ctgggaggcg caaaagtacc gcacctgatg    960

 ccgggtgact cactgaacct gcagacggct caggatacgg ataacggcta ctccgtgttt   1020

 gagcagtcac tgctgcggta tatcgctgcc gggctgggtg tctcgtatga gcagctttcc   1080

 cggaattacg cccagatgag ctactccacg gcacgggcca gtgcgaacga gtcgtgggcg   1140

 tactttatgg ggcggcgaaa attcgtcgca tcccgtcagg cgagccagat gtttctgtgc   1200

 tggctggaag aggccatcgt tcgccgcgtg gtgacgttac cttcaaaagc gcgcttcagt   1260

 tttcaggaag cccgcagtgc ctgggggaac tgcgactgga taggctccgg tcgtatggcc   1320

 atcgatggtc tgaaagaagt tcaggaagcg gtgatgctga tagaagccgg actgagtacc   1380

 tacgagaaag agtgcgcaaa acgcggtgac gactatcagg aaatttttgc ccagcaggtc   1440

 cgtgaaacga tggagcgccg tgcagccggt cttaaaccgc ccgcctgggc ggctgcagca   1500

 tttgaatccg ggctgcgaca atcaacagag gaggagaaga gccagcttgg gatcagcagc   1560

 ctgacggatg cggtgtccgg cgacagcctg actgcccagg aggcactcgc gacgctggca   1620

 ttatccggtg atgatgacgg accacgacag gcccgcagtt atcaggtcat gaacggcatc   1680

 gccgtgctgc cggtgtccgg cacgctggtc agccggacgc gggcgctgca gccgtactcg   1740

 gggatgaccg gttacaacgg cattatcgcc cgtctgcaac aggctgccag cgatccgatg   1800

 gtggacggca ttctgctcga tatggacacg cccggcggga tggtggcggg ggcatttgac   1860

 tgcgctgaca tcatcgcccg tgtgcgtgac ataaaaccgg tatgggcgct tgccaacgac   1920

 atgaactgca gtgcaggtca gttgcttgcc agtgccgcct cccggcgtct ggtcacgcag   1980

 accgcccgga caggctccat cggcgtcatg atggctcaca gtaattacgg tgctgcgctg   2040

 gagaaacagg gtgtggaaat cacgctgatt tacagcggca gccataaggt ggatggcaac   2100

 ccctacagcc atcttccgga tgacgtccgg gagacactgc agtcccggat ggacgcaacc   2160

 cgccagatgt ttgcgcagaa ggtgtcggca tataccggcc tgtccgtgca ggttgtgctg   2220

 gataccgagg ctgcagtgta cagcggtcag gaggccattg atgccggact ggctgatgaa   2280

 cttgttaaca gcaccgatgc gatcaccgtc atgcgtgatg cactggatgc acgtaaatcc   2340

 cgtctctcag gagggcgaat gaccaaagag actcaatcaa caactgtttc agccactgct   2400

 tcgcaggctg acgttactga cgtggtgcca gcgacggagg gcgagaacgc cagcgcggcg   2460

 cagccggacg tgaacgcgca gatcaccgca gcggttgcgg cagaaaacag ccgcattatg   2520

 gggatactca actgtgagga ggctcacgga cgcgaagaac aggcacgcgt gctggcagaa   2580

 acccccggta tgaccgtgaa aacggcccgc cgcattctgg ccgcagcacc acagagtgca   2640

 caggcgcgca gtgacactgc gctggatcgt ctgatgcagg gggcaccggc accgctggct   2700

 gcaggtaacc cggcatctga tgccgttaac gatttgctga acacaccagt ccgtaagctg   2760

 gttgcgtggg atggcaccac cgacggtgct gccgttggca ttcttgcggt tgctgctgac   2820

 cagaccagca ccacgctgac gttctacaag tccggcacgt tccgttatga ggatgtgctc   2880

 tggccggagg ctgccagcga cgagacgaaa aaacggaccg cgccgcctgt gcggcttttt   2940

 ttacgggatt ttttt atg tcg atg tac aca acc gcc caa ctg ctg gcg gca    2991
                  Met Ser Met Tyr Thr Thr Ala Gln Leu Leu Ala Ala
                    1               5                  10

 aat gag cag aaa ttt aag ttt gat ccg ctg ttt ctg cgt ctc ttt ttc     3039
 Asn Glu Gln Lys Phe Lys Phe Asp Pro Leu Phe Leu Arg Leu Phe Phe
          15                  20                  25

 cgt gag agc tat ccc ttc acc acg gag aaa gtc tat ctc tca caa att     3087
 Arg Glu Ser Tyr Pro Phe Thr Thr Glu Lys Val Tyr Leu Ser Gln Ile
      30                  35                  40

 ccg gga ctg gta aac atg gcg ctg tac gtt tcg ccg att gtt tcc ggt     3135
 Pro Gly Leu Val Asn Met Ala Leu Tyr Val Ser Pro Ile Val Ser Gly
  45                  50                  55                  60

 gag gtt atc cgt tcc cgt ggc ggc tcc acc tct gaa ttt acg ccg gga     3183
 Glu Val Ile Arg Ser Arg Gly Gly Ser Thr Ser Glu Phe Thr Pro Gly
                  65                  70                  75

 tat gtc aag ccg aag cat gaa gtg aat ccg cag atg acc ctg cgt cgc     3231
 Tyr Val Lys Pro Lys His Glu Val Asn Pro Gln Met Thr Leu Arg Arg
              80                  85                  90

 ctg ccg gat gaa gat ccg cag aat ctg gcg gac ccg gct tac cgc cgc     3279
 Leu Pro Asp Glu Asp Pro Gln Asn Leu Ala Asp Pro Ala Tyr Arg Arg
          95                 100                 105

 cgt cgc atc atc atg cag aac atg cgt gac gaa gag ctg gcc att gct     3327
 Arg Arg Ile Ile Met Gln Asn Met Arg Asp Glu Glu Leu Ala Ile Ala
     110                 115                 120

 cag gtc gaa gag atg cag gca gtt tct gcc gtg ctt aag ggc aaa tac     3375
 Gln Val Glu Glu Met Gln Ala Val Ser Ala Val Leu Lys Gly Lys Tyr
 125                 130                 135                 140

 acc atg acc ggt gaa gcc ttc gat ccg gtt gag gtg gat atg ggc cgc     3423
 Thr Met Thr Gly Glu Ala Phe Asp Pro Val Glu Val Asp Met Gly Arg
                 145                 150                 155

 agt gag gag aat aac atc acg cag tcc ggc ggc acg gag tgg agc aag     3471
 Ser Glu Glu Asn Asn Ile Thr Gln Ser Gly Gly Thr Glu Trp Ser Lys
             160                 165                 170

 cgt gac aag tcc acg tat gac ccg acc gac gat atc gaa gcc tac gcg     3519
 Arg Asp Lys Ser Thr Tyr Asp Pro Thr Asp Asp Ile Glu Ala Tyr Ala
         175                 180                 185

 ctg aac gcc agc ggt gtg gtg aat atc atc gtg ttc gat ccg aaa ggc     3567
 Leu Asn Ala Ser Gly Val Val Asn Ile Ile Val Phe Asp Pro Lys Gly
     190                 195                 200

 tgg gcg ctg ttc cgt tcc ttc aaa gcc gtc aag gag aag ctg gat acc     3615
 Trp Ala Leu Phe Arg Ser Phe Lys Ala Val Lys Glu Lys Leu Asp Thr
 205                 210                 215                 220

 cgt cgt ggc tct aat tcc gag ctg gag aca gcg gtg aaa gac ctg ggc     3663
 Arg Arg Gly Ser Asn Ser Glu Leu Glu Thr Ala Val Lys Asp Leu Gly
                 225                 230                 235

 aaa gcg gtg tcc tat aag ggg atg tat ggc gat gtg gcc atc gtc gtg     3711
 Lys Ala Val Ser Tyr Lys Gly Met Tyr Gly Asp Val Ala Ile Val Val
             240                 245                 250

 tat tcc gga cag tac gtg gaa aac ggc gtc aaa aag aac ttc ctg ccg     3759
 Tyr Ser Gly Gln Tyr Val Glu Asn Gly Val Lys Lys Asn Phe Leu Pro
         255                 260                 265

 gac aac acg atg gtg ctg ggg aac act cag gca cgc ggt ctg cgc acc     3807
 Asp Asn Thr Met Val Leu Gly Asn Thr Gln Ala Arg Gly Leu Arg Thr
     270                 275                 280

 tat ggc tgc att cag gat gcg gac gca cag cgc gaa ggc att aac gcc     3855
 Tyr Gly Cys Ile Gln Asp Ala Asp Ala Gln Arg Glu Gly Ile Asn Ala
 285                 290                 295                 300

 tct gcc cgt tac ccg aaa aac tgg gtg acc acc ggc gat ccg gcg cgt     3903
 Ser Ala Arg Tyr Pro Lys Asn Trp Val Thr Thr Gly Asp Pro Ala Arg
                 305                 310                 315

 gag ttc acc atg att cag tca gca ccg ctg atg ctg ctg gct gac cct     3951
 Glu Phe Thr Met Ile Gln Ser Ala Pro Leu Met Leu Leu Ala Asp Pro
             320                 325                 330

 gat gag ttc gtg tcc gta caa ctg gcg taatc atggcccttc ggggccattg     4003
 Asp Glu Phe Val Ser Val Gln Leu Ala 
         335                 340

 tttctctgtg gaggagtcca tgacgaaaga tgaactgatt gcccgtcttc gctcgctggg   4063

 tgaacaactt gaacccggat gtcaagcctg acgggggacg aaagaagaac tggcgctccg   4123

 ttgttggcaa gagcttgaaa gaggagcttg atgacacgag g                       4164




      <210> 159
      <211> 479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(422)

      <400> 159
 gtgataccca ggtaaacagg gtctggagtg gatctccaac aaactccagc agacctgcag     60

 cagaggggcc tgactgttat aaggaaaact aacaaacaga aaggaatagc gtcaacatca    120

 acaaaaagga catccacaca gaaaccccat gcaaaggtca ccagcatcaa agaccaaagg    180

 tagataaatc c atg aag atg agg aaa aac cag tgc aaa aag gct gaa aat     230
              Met Lys Met Arg Lys Asn Gln Cys Lys Lys Ala Glu Asn
                1               5                  10

 tcc aaa aac cag aat ggc tct tct cct gca aag gat tac aac tcc tca      278
 Ser Lys Asn Gln Asn Gly Ser Ser Pro Ala Lys Asp Tyr Asn Ser Ser
      15                  20                  25

 cca gca agg gaa caa aac tgg atg gaa aat tgg tta gac aaa ttg aca      326
 Pro Ala Arg Glu Gln Asn Trp Met Glu Asn Trp Leu Asp Lys Leu Thr
  30                  35                  40                  45

 gaa gta ggc ttc atc agg tgg ata ata aca aac tct ttc aag cta aag      374
 Glu Val Gly Phe Ile Arg Trp Ile Ile Thr Asn Ser Phe Lys Leu Lys
                  50                  55                  60

 gag cat gtt cta acc caa tgc aag gaa cta aga agc ttg aaa aaa agt      422
 Glu His Val Leu Thr Gln Cys Lys Glu Leu Arg Ser Leu Lys Lys Ser 
              65                  70                  75

 tagaggaact gctgactaaa ataatcagtt tagagaagac catcaggttt aggggaa       479




      <210> 160
      <211> 1566
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(585)

      <400> 160
 tgggcggcgg cggcggcggc ggtc   atg gaa cgc caa gag gag tct ctg tcc      51
                              Met Glu Arg Gln Glu Glu Ser Leu Ser
                                1               5

 gcg cgg ccg gcc ctg gag acc gag ggg ctg cgc ttc ctg cac acc acg       99
 Ala Arg Pro Ala Leu Glu Thr Glu Gly Leu Arg Phe Leu His Thr Thr
  10                  15                  20                  25

 gtg ggc tcc ctg ctg gcc acc tat ggc tgg tac atc gtc ttc agc tgc      147
 Val Gly Ser Leu Leu Ala Thr Tyr Gly Trp Tyr Ile Val Phe Ser Cys
                  30                  35                  40

 atc ctt ctc tac gtg gtc ttt cag aag ctt tcc gcc cgg cta aga gcc      195
 Ile Leu Leu Tyr Val Val Phe Gln Lys Leu Ser Ala Arg Leu Arg Ala
              45                  50                  55

 ttg agg cag agg cag ctg gac cga gct gcg gct gct gtg gaa cct gat      243
 Leu Arg Gln Arg Gln Leu Asp Arg Ala Ala Ala Ala Val Glu Pro Asp
          60                  65                  70

 gtt gtt gtt aaa cga caa gaa gct tta gca gct gct cga ctg aaa atg      291
 Val Val Val Lys Arg Gln Glu Ala Leu Ala Ala Ala Arg Leu Lys Met
      75                  80                  85

 caa gaa gaa cta aat gcg caa gtt gaa aag cat aag gaa aaa ctg aaa      339
 Gln Glu Glu Leu Asn Ala Gln Val Glu Lys His Lys Glu Lys Leu Lys
  90                  95                 100                 105

 caa ctt gaa gaa gaa aaa agg aga cag aag att gaa atg tgg gac agc      387
 Gln Leu Glu Glu Glu Lys Arg Arg Gln Lys Ile Glu Met Trp Asp Ser
                 110                 115                 120

 atg caa gaa gga aaa agt tac aaa gga aat gca aag aag ccc cag gag      435
 Met Gln Glu Gly Lys Ser Tyr Lys Gly Asn Ala Lys Lys Pro Gln Glu
             125                 130                 135

 gaa gac agt cct ggg cct tcc act tca tct gtc ctg aaa cgg aaa tcg      483
 Glu Asp Ser Pro Gly Pro Ser Thr Ser Ser Val Leu Lys Arg Lys Ser
         140                 145                 150

 gac aga aag cct ttg cgg gga gga ggt tat aac ccg ttg tct ggt gaa      531
 Asp Arg Lys Pro Leu Arg Gly Gly Gly Tyr Asn Pro Leu Ser Gly Glu
     155                 160                 165

 gga ggc gga gct tgc tcc tgg aga cct gga cgc aga ggc ccg tca tct      579
 Gly Gly Gly Ala Cys Ser Trp Arg Pro Gly Arg Arg Gly Pro Ser Ser
 170                 175                 180                 185

 ggc gga tgaggctaag aatcttgtta gtgtcacttt tgacattagc aagatgaacc       635
 Gly Gly 


 cttaaccctc gattcaattg ccttacgcac gcttttcaca gtgactagcc aaggggaggt    695

 ggggttgatt tctgttccta actacacctg catatgtcag ggctccagtc agcaaaaggt    755

 atagatgttg cctctaggca tgaggtcatt ggtcacattc tacttggaga cagtgattgc    815

 attcattgat ttcatggtta attgctagtt ggtaggtaaa ggcctctaga tgattagcaa    875

 tcttgataaa agaggcctag taatgttctt ttgaggttag aaatccttgc tgctaggaca    935

 gtctctgtga caggttgcgt tgaatgatgt cttccttatc aatggtgagc ccaccagtga    995

 ggattactga tgtggacagt tgatggggtt tgtttctgta tatttatttt tatgtacaga   1055

 actttgtaaa aacgaaacta tttaaaaaac aagaataaca tttttagcat ctttatttaa   1115

 tgtttgatag acaaattgaa gtccataaat ctccttgaat aaagatgcta aaaatgttat   1175

 tcttgttttt taaatagttt cgtttttaca aagttctgta cataaaaata aatatacaga   1235

 aacaaacccc atcaactgtc cacatcagta atcctcactg gtgggctcac cattgataag   1295

 gaagacatca ttcaacgcaa cctgtcacag agactgtcct agcagcaagg atttctaacc   1355

 tcaaaagaac attactaggc ctcttttatc aagattgcta atcatctaga ggcctttacc   1415

 taccaactag caattaacca tgaaatcaat gaatgcaatc actgtctcca agtagaatgt   1475

 gaccaatgac ctcatgccta gaggaacatc tatacctttt gctgactgga gccctgacat   1535

 atgcaggtgt agttaggaac agaaatcaac c                                  1566




      <210> 161
      <211> 2450
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (89)..(883)

      <400> 161
 ttctcacgct ttggctgtct ggacttttaa gtttttccgc tttttcagga aggcgaccgg     60

 cagcctcggg caggggagac aggactgt   atg tca gag aag aga cgg cgc ttg     112
                                  Met Ser Glu Lys Arg Arg Arg Leu
                                    1               5

 gac gcc agg aat cct ctg aag cag gag act gcc cta tcc agg tta ccc      160
 Asp Ala Arg Asn Pro Leu Lys Gln Glu Thr Ala Leu Ser Arg Leu Pro
      10                  15                  20

 ttc ccg agg gga aac cag ggt ctc ctt cag aaa gct gag gca ggc cgg      208
 Phe Pro Arg Gly Asn Gln Gly Leu Leu Gln Lys Ala Glu Ala Gly Arg
  25                  30                  35                  40

 gcg cgg tgg ctc acg cct gta atc cca gca ctt tgg aag acc gag gcg      256
 Ala Arg Trp Leu Thr Pro Val Ile Pro Ala Leu Trp Lys Thr Glu Ala
                  45                  50                  55

 ggc gga tca cct gag aag atg act caa gac cgg cct ctg ctt gcc gtg      304
 Gly Gly Ser Pro Glu Lys Met Thr Gln Asp Arg Pro Leu Leu Ala Val
              60                  65                  70

 cag gag gcg ctg aag aag tgc ttc ccc gtg gtg gag gag cag cag ggc      352
 Gln Glu Ala Leu Lys Lys Cys Phe Pro Val Val Glu Glu Gln Gln Gly
          75                  80                  85

 ctg tgg cag agt gcc ctg cgg gac tgc cag ccc ctc ctg tcc tcc ctc      400
 Leu Trp Gln Ser Ala Leu Arg Asp Cys Gln Pro Leu Leu Ser Ser Leu
      90                  95                 100

 agc aac ctg gcg gaa cag ctg cag gcc gca cag aac ctg cgg ttt gag      448
 Ser Asn Leu Ala Glu Gln Leu Gln Ala Ala Gln Asn Leu Arg Phe Glu
 105                 110                 115                 120

 gat gtg ccg gcg ctt cgg gcc ttc cca gat tta aaa gag cgg ctg agg      496
 Asp Val Pro Ala Leu Arg Ala Phe Pro Asp Leu Lys Glu Arg Leu Arg
                 125                 130                 135

 cgt aag cag ctg gtg gct ggt gac atc gtc ctg gac aag cta ggg gaa      544
 Arg Lys Gln Leu Val Ala Gly Asp Ile Val Leu Asp Lys Leu Gly Glu
             140                 145                 150

 agg cta gcc atc ctc ctc aag gtg cga gac atg gtc agc agc cat gtg      592
 Arg Leu Ala Ile Leu Leu Lys Val Arg Asp Met Val Ser Ser His Val
         155                 160                 165

 gag cga gtg ttt cag atc tat gag caa cac gca gac aca gtt ggc att      640
 Glu Arg Val Phe Gln Ile Tyr Glu Gln His Ala Asp Thr Val Gly Ile
     170                 175                 180

 gat gct gtc ctg cag cct tca gca gtg agc ccc tct gtg gct gac atg      688
 Asp Ala Val Leu Gln Pro Ser Ala Val Ser Pro Ser Val Ala Asp Met
 185                 190                 195                 200

 ttg gaa tgg ttg cag gat att gag aga cat tat cga aag tcg tac ctg      736
 Leu Glu Trp Leu Gln Asp Ile Glu Arg His Tyr Arg Lys Ser Tyr Leu
                 205                 210                 215

 aag aga aag tat ctt ctt tcg tct atc cag tgg gga gac ttg gca aac      784
 Lys Arg Lys Tyr Leu Leu Ser Ser Ile Gln Trp Gly Asp Leu Ala Asn
             220                 225                 230

 ata caa gct ttg ccc aag gcc tgg gac cga att tca aaa gac gaa cac      832
 Ile Gln Ala Leu Pro Lys Ala Trp Asp Arg Ile Ser Lys Asp Glu His
         235                 240                 245

 cat gat ctt gta caa gat atc cta ttg aat gtt tcc ttc ttc ctg gaa      880
 His Asp Leu Val Gln Asp Ile Leu Leu Asn Val Ser Phe Phe Leu Glu
     250                 255                 260

 gag taag gaagctatgc gtatctggag accacgggca ccacagttga agactgacat      937
 Glu 
 265

 tctgaaccct gatgtttcta aagaaacgtc agtatttcag tctgacatat ttgaaacatc    997

 agtgccttga accttaggac tgggtcttgg ggaggattag cgcctagatg tctgattttg   1057

 gagctgcagc atgccaggcc gtggctgaga gtatgtgagc catgccttgc ccttttctga   1117

 ggctcaggga agtggatgga gctagagagg caacaggaaa gacggtgctg aagaacatag   1177

 tgtctttcct ctattgtgga cctaaagagg tggggaagca aggacaagag gcaaagagcc   1237

 acactgccct tggcatcatc caaagcattg tctggttgac accaggtcct ggttttgtgt   1297

 cttttgtcaa tacctgaatc cttgacaaaa gaaaaagtgg ttttgatgat ttaaagaaat   1357

 aagggtgatt ttgacagaaa atatatttta aaaattttga ccaattgcaa tagttatcct   1417

 caagccaatt tccagaacct gccaccaggg ggaggtggtg cagcatgaat cattctgaat   1477

 gctttgtctt tgaagtgttc ccctattgct gttaccatct cagaggaagt aactgggcat   1537

 ggtgagactc ctaaaatgac aggagttttt ttggccaaag ctggcatctg acttgccaca   1597

 ttcctctgag tctggagtag ccgcaggggt gggagaatgc cagcccagag tcagtccatc   1657

 ggggttacat ttccaaggtc tgctgccttc atctatgtaa tggccgtgtt actttcagat   1717

 ctttcagctt cccagagtgt tgtgggaatc ttggtcattg aatgtaaagg gacttagtaa   1777

 agggtataga tatttttcaa aaatgaaaat aacttttttt cttataagtg ataagctttt   1837

 ataaagatca taggaaaact agaaaaaatg taaaatgtag aaaattgtaa aacaaacttc   1897

 attagagata ttttgataga taccttttca gtgtctattt acaaattttt tcttttaata   1957

 tagatagggt ctcactatat tgcccagctc actcctgagc tcaagggatc ctcccaccat   2017

 agcctcccaa aatattggaa atacaggcat gagccactgc tcctgaccaa ttcacaaatt   2077

 tttttaaaga acaaacgtgc tatcatcgat acatactgtt aggttgtctt tttttaaaaa   2137

 acctaatgta atttgttcat ctttttatat ctgtaaatat agctcaacac agttatattc   2197

 tttttgtgaa tgtattatat ctacaattta ccttttttct tagattttac atgcattttc   2257

 ccaaatcttt gtgtttgcct atctgtaaag gtaatacatt ctgattacaa aaaatgaaaa   2317

 tgttacatag aaatgtaccg ttatccatct accagataac tattattaat aatgtgtatt   2377

 tatttttcca ggaattaaaa aacatctatc atataagtat tgcaaataaa acttaaaaag   2437

 caaaaaaaaa aaa                                                      2450




      <210> 162
      <211> 1431
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (401)..(1381)

      <400> 162
 ctgcctcaga taaagtgcaa aggccagtct gcagggatag tttcatcctc tccccacgcg     60

 atgggctaca catcacctgc ccaagctctc tcccgacctg ctagagccta gagggcggag    120

 gccggagagg ctgcagccgg gagtagcacc gcacatccgg gaacgccagc agcgggctga    180

 gggctgcata actgatggaa ggccgggcgc ggtaagagcg tctcggggag tagggcaagg    240

 cggccgggcc cctcccattc cgccttttct tcagcgtcct acccgcggca ctggctgcga    300

 gcgccgggcc acctgcgagt gtgcgcaggg actctggaca cccgcggcgg cgagctgagg    360

 gagcagtctc cacgaggacc caggcggacc ctctggcgcc  atg cgc gcc ctc ccc     415
                                              Met Arg Ala Leu Pro
                                                1               5

 ggc ctg ctg gag gcc agg gcg cgt acg ccc cgg ctg ctc ctc ctc cag      463
 Gly Leu Leu Glu Ala Arg Ala Arg Thr Pro Arg Leu Leu Leu Leu Gln
                  10                  15                  20

 tgc ctt ctc gct gcc gcg cgc cca agc tcg gcg gac ggc agt gcc cca      511
 Cys Leu Leu Ala Ala Ala Arg Pro Ser Ser Ala Asp Gly Ser Ala Pro
              25                  30                  35

 gat tcg cct ttt aca agt cca cct ctc aga gaa gaa ata atg gca aat      559
 Asp Ser Pro Phe Thr Ser Pro Pro Leu Arg Glu Glu Ile Met Ala Asn
          40                  45                  50

 aac ttt tcc ttg gag agt cat aac ata tca ctg act gaa cat tct agt      607
 Asn Phe Ser Leu Glu Ser His Asn Ile Ser Leu Thr Glu His Ser Ser
      55                  60                  65

 atg cca gta gaa aaa aat atc act tta gaa agg cct tct aat gta aat      655
 Met Pro Val Glu Lys Asn Ile Thr Leu Glu Arg Pro Ser Asn Val Asn
  70                  75                  80                  85

 ctc aca tgc cag ttc aca aca tct ggg gat ttg aat gca gta aat gtg      703
 Leu Thr Cys Gln Phe Thr Thr Ser Gly Asp Leu Asn Ala Val Asn Val
                  90                  95                 100

 act tgg aaa aaa gat ggt gaa caa ctt gag aat aat tat ctt gtc agt      751
 Thr Trp Lys Lys Asp Gly Glu Gln Leu Glu Asn Asn Tyr Leu Val Ser
             105                 110                 115

 gca aca gga agc acc ttg tat acc caa tac agg ttc acc atc att aat      799
 Ala Thr Gly Ser Thr Leu Tyr Thr Gln Tyr Arg Phe Thr Ile Ile Asn
         120                 125                 130

 agc aaa caa atg gga agt tat tct tgt ttc ttt cga gag gaa aag gaa      847
 Ser Lys Gln Met Gly Ser Tyr Ser Cys Phe Phe Arg Glu Glu Lys Glu
     135                 140                 145

 caa agg gga aca ttt aat ttc aaa gtc cct gaa ctt cat ggg aaa aac      895
 Gln Arg Gly Thr Phe Asn Phe Lys Val Pro Glu Leu His Gly Lys Asn
 150                 155                 160                 165

 aag cca ttg atc tct tac gta ggg gat tct act gtc ttg aca tgt aaa      943
 Lys Pro Leu Ile Ser Tyr Val Gly Asp Ser Thr Val Leu Thr Cys Lys
                 170                 175                 180

 tgt caa aat tgt ttt cct tta aat tgg acc tgg tac agt agt aat ggg      991
 Cys Gln Asn Cys Phe Pro Leu Asn Trp Thr Trp Tyr Ser Ser Asn Gly
             185                 190                 195

 agt gta aag gtt cct gtt ggt gtt caa atg aat aaa tat gtg atc aat     1039
 Ser Val Lys Val Pro Val Gly Val Gln Met Asn Lys Tyr Val Ile Asn
         200                 205                 210

 gga aca tat gct aac gaa aca aag ctg aag ata aca caa ctt ttg gag     1087
 Gly Thr Tyr Ala Asn Glu Thr Lys Leu Lys Ile Thr Gln Leu Leu Glu
     215                 220                 225

 gaa gat ggg gaa tct tac tgg tgc cgt gca cta ttc caa tta ggc gag     1135
 Glu Asp Gly Glu Ser Tyr Trp Cys Arg Ala Leu Phe Gln Leu Gly Glu
 230                 235                 240                 245

 agt gaa gaa cac att gag ctt gtg gtg ctg agc tat ttg gtg ccc ctc     1183
 Ser Glu Glu His Ile Glu Leu Val Val Leu Ser Tyr Leu Val Pro Leu
                 250                 255                 260

 aaa cca ttt ctt gta ata gtg gct gag gtg att ctt tta gtg gcc acc     1231
 Lys Pro Phe Leu Val Ile Val Ala Glu Val Ile Leu Leu Val Ala Thr
             265                 270                 275

 att ctg ctt tgt gaa aag tac aca caa aag aaa aag aag cac tca gat     1279
 Ile Leu Leu Cys Glu Lys Tyr Thr Gln Lys Lys Lys Lys His Ser Asp
         280                 285                 290

 gag ggg aaa gaa ttt gag cag att gaa cag ctg aaa tca gat gat agc     1327
 Glu Gly Lys Glu Phe Glu Gln Ile Glu Gln Leu Lys Ser Asp Asp Ser
     295                 300                 305

 aat ggt ata gaa aat aat gtc ccc agg cat aga aaa aat gag tct ctg     1375
 Asn Gly Ile Glu Asn Asn Val Pro Arg His Arg Lys Asn Glu Ser Leu
 310                 315                 320                 325

 ggc cag tgaatacaaa acatcatgtc gagaatcatt ggaagatata cagagttcgt      1431
 Gly Gln 






      <210> 163
      <211> 1412
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (107)..(1186)

      <400> 163
 taagcttgcg gccgccgctc aggtcaggca gccccagcgt ccccgggccc tcggtcccac     60

 cgagtgccgg ctcccgcgct ctgcgcaagc ccttggaatt ttcaaa   atg aat tat     115
                                                      Met Asn Tyr
                                                        1

 aca gag tcc agc cca ttg aga gaa tca act gcc ata ggt ttt aca cct      163
 Thr Glu Ser Ser Pro Leu Arg Glu Ser Thr Ala Ile Gly Phe Thr Pro
       5                  10                  15

 gag tta gaa agt atc ata cct gtg cct tcc aat aag acc act tgt gaa      211
 Glu Leu Glu Ser Ile Ile Pro Val Pro Ser Asn Lys Thr Thr Cys Glu
  20                  25                  30                  35

 aac tgg aga gag ata cat cat ctg gtt ttt cat gta gca aat att tgt      259
 Asn Trp Arg Glu Ile His His Leu Val Phe His Val Ala Asn Ile Cys
                  40                  45                  50

 ttt gca gtt ggg ttg gtt att cca act act ctt cac ctt cat atg ata      307
 Phe Ala Val Gly Leu Val Ile Pro Thr Thr Leu His Leu His Met Ile
              55                  60                  65

 ttt ctt agg gga atg tta act cta gga tgt acc ctt tat atc gtc tgg      355
 Phe Leu Arg Gly Met Leu Thr Leu Gly Cys Thr Leu Tyr Ile Val Trp
          70                  75                  80

 gcc act ctc tac cga tgt gcc ttg gat ata atg atc tgg aac tct gtg      403
 Ala Thr Leu Tyr Arg Cys Ala Leu Asp Ile Met Ile Trp Asn Ser Val
      85                  90                  95

 ttc ttg ggt gtc aac att ttg cat ctg tcg tat ctt tta tac aag aag      451
 Phe Leu Gly Val Asn Ile Leu His Leu Ser Tyr Leu Leu Tyr Lys Lys
 100                 105                 110                 115

 aga ccg gta aag att gaa aag gaa ctc agt ggc atg tac cgg cga ttg      499
 Arg Pro Val Lys Ile Glu Lys Glu Leu Ser Gly Met Tyr Arg Arg Leu
                 120                 125                 130

 ttt gaa cca ctc cgt gtg cct cca gat ttg ttc aga aga cta act gga      547
 Phe Glu Pro Leu Arg Val Pro Pro Asp Leu Phe Arg Arg Leu Thr Gly
             135                 140                 145

 cag ttt tgc atg atc caa acc ttg aaa aag ggc caa act tat gct gca      595
 Gln Phe Cys Met Ile Gln Thr Leu Lys Lys Gly Gln Thr Tyr Ala Ala
         150                 155                 160

 gag gat aaa acc tca gtt gat gac cgt ctg agt att ctc ttg aag gga      643
 Glu Asp Lys Thr Ser Val Asp Asp Arg Leu Ser Ile Leu Leu Lys Gly
     165                 170                 175

 aaa atg aag gtc tcc tat cga gga cat ttt ctg cat aac att tac ccc      691
 Lys Met Lys Val Ser Tyr Arg Gly His Phe Leu His Asn Ile Tyr Pro
 180                 185                 190                 195

 tgt gcc ttt ata gat tct cct gaa ttt aga tca act cag atg cac aaa      739
 Cys Ala Phe Ile Asp Ser Pro Glu Phe Arg Ser Thr Gln Met His Lys
                 200                 205                 210

 ggt gaa aaa ttc cag gtc acc att att gca gat gat aac tgc aga ttt      787
 Gly Glu Lys Phe Gln Val Thr Ile Ile Ala Asp Asp Asn Cys Arg Phe
             215                 220                 225

 tta tgc tgg tca aga gaa aga tta aca tac ttt ctg gaa tca gaa cct      835
 Leu Cys Trp Ser Arg Glu Arg Leu Thr Tyr Phe Leu Glu Ser Glu Pro
         230                 235                 240

 ttc ttg tat gaa atc ttt agg tat ctt att gga aaa gac atc aca aat      883
 Phe Leu Tyr Glu Ile Phe Arg Tyr Leu Ile Gly Lys Asp Ile Thr Asn
     245                 250                 255

 aag ctc tac tca ttg aat gat ccc acc tta aat gat aaa aaa gcc aaa      931
 Lys Leu Tyr Ser Leu Asn Asp Pro Thr Leu Asn Asp Lys Lys Ala Lys
 260                 265                 270                 275

 aag ctg gaa cat cag ctc agc ctc tgc aca cag atc tcc atg ttg gaa      979
 Lys Leu Glu His Gln Leu Ser Leu Cys Thr Gln Ile Ser Met Leu Glu
                 280                 285                 290

 atg agg aac agt ata gcc agc tcc agt gac agt gac gac ggc ttg cac     1027
 Met Arg Asn Ser Ile Ala Ser Ser Ser Asp Ser Asp Asp Gly Leu His
             295                 300                 305

 cag ttt ctt cgg ggt acc tcc agc atg tcc tct ctt cat gtg tca tcc     1075
 Gln Phe Leu Arg Gly Thr Ser Ser Met Ser Ser Leu His Val Ser Ser
         310                 315                 320

 cca cac cag cga gcc tct gcc aag atg aaa ccg ata gaa gaa gga gca     1123
 Pro His Gln Arg Ala Ser Ala Lys Met Lys Pro Ile Glu Glu Gly Ala
     325                 330                 335

 gaa gat gat gat gac gtt ttt gaa ccg gca tct cca aat aca ttg aaa     1171
 Glu Asp Asp Asp Asp Val Phe Glu Pro Ala Ser Pro Asn Thr Leu Lys
 340                 345                 350                 355

 gtc cat cag ctg cct tgatcagaga gagaattcag gttaccaaga cggaaggtgt     1226
 Val His Gln Leu Pro 
                 360

 cttgaagaga tcctgaaaaa taccagcact ttttcatggc ttttaggtta ttctgcttta   1286

 gtgcatccag actggtagag tcggagggag gaagtgagga agggtcaagg atggaagagt   1346

 tctttcactt acccttttta ttagtcagct tttaaagtaa ttgttttact gaaaaaaaaa   1406

 aaaaaa                                                              1412




      <210> 164
      <211> 1814
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (278)..(1192)

      <400> 164
 agaggaccca ggtgtcctgg cagtgggcgc cgcggggcac acgctgggcc aaggtgcagg     60

 cggccagggt gggagactgt tcgccccgcc ctgagtactc ctatcttgtt tctccacctg    120

 ttcgggagtt ggagatgtgc acctaaagga ggcgcatctg gggacggaca catctggcac    180

 tgaggccctc gccacctgcc tcgccacctg gcgaccctga ccccaccaca ctgccttgag    240

 agtcgctcaa aagtagggcc ccagggctcg cagcagc atg ggc acc gag aaa gaa     295
                                          Met Gly Thr Glu Lys Glu
                                            1               5

 agc cca gag ccc gac tgc cag aaa cag ttc cag gct gca gtg agc gtc      343
 Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe Gln Ala Ala Val Ser Val
              10                  15                  20

 atc cag aac ctg ccc aag aac ggt tct tac cgc ccc tcc tat gaa gag      391
 Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr Arg Pro Ser Tyr Glu Glu
          25                  30                  35

 atg ctg cga ttc tac agt tac tac aag cag gcc acc atg ggg ccc tgc      439
 Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln Ala Thr Met Gly Pro Cys
      40                  45                  50

 ctg gtc ccc cgg ccc ggg ttc tgg gac ccc att gga cga tat aag tgg      487
 Leu Val Pro Arg Pro Gly Phe Trp Asp Pro Ile Gly Arg Tyr Lys Trp
  55                  60                  65                  70

 gac gcc tgg aac agt ctg ggc aag atg agc agg gag gag gcc atg tct      535
 Asp Ala Trp Asn Ser Leu Gly Lys Met Ser Arg Glu Glu Ala Met Ser
                  75                  80                  85

 gcc tac atc act gaa atg aaa ctg gtg gca cag aag gtg atc gac aca      583
 Ala Tyr Ile Thr Glu Met Lys Leu Val Ala Gln Lys Val Ile Asp Thr
              90                  95                 100

 gtg ccc ctg ggt gag gtg gca gag gac atg ttt ggt tac ttc gag ccc      631
 Val Pro Leu Gly Glu Val Ala Glu Asp Met Phe Gly Tyr Phe Glu Pro
         105                 110                 115

 ctg tac cag gtg atc cct gac atg ccg agg ccc cca gag acc ttc ctg      679
 Leu Tyr Gln Val Ile Pro Asp Met Pro Arg Pro Pro Glu Thr Phe Leu
     120                 125                 130

 aga agg gtc aca ggt tgg aaa gag cag gtt gtg aat gga gat gtt ggg      727
 Arg Arg Val Thr Gly Trp Lys Glu Gln Val Val Asn Gly Asp Val Gly
 135                 140                 145                 150

 gct gtt tca gag cct ccc tgc ctc ccc aag gaa ccg gca ccc cca agc      775
 Ala Val Ser Glu Pro Pro Cys Leu Pro Lys Glu Pro Ala Pro Pro Ser
                 155                 160                 165

 cca gag tcc cat tca ccc agg gac ctg gac tcc gag gtt ttc tgt gat      823
 Pro Glu Ser His Ser Pro Arg Asp Leu Asp Ser Glu Val Phe Cys Asp
             170                 175                 180

 tcc ctg gag cag ctg gag cct gag ctg gtt tgg aca gag cag cgg gca      871
 Ser Leu Glu Gln Leu Glu Pro Glu Leu Val Trp Thr Glu Gln Arg Ala
         185                 190                 195

 gca tct gga gga aag cgt gat ccc agg aac agc ccc gtg ccc ccc aca      919
 Ala Ser Gly Gly Lys Arg Asp Pro Arg Asn Ser Pro Val Pro Pro Thr
     200                 205                 210

 aag aaa gag ggg ttg cgg ggc agc ccg ccg ggg ccc cag gag ttg gac      967
 Lys Lys Glu Gly Leu Arg Gly Ser Pro Pro Gly Pro Gln Glu Leu Asp
 215                 220                 225                 230

 gtg tgg ctg ctg ggg aca gtt cga gca cta cag gag agc atg cag gag     1015
 Val Trp Leu Leu Gly Thr Val Arg Ala Leu Gln Glu Ser Met Gln Glu
                 235                 240                 245

 gtg cag gcg agg gtg cag agc ctg gag agc atg ccc cgg ccc cct gag     1063
 Val Gln Ala Arg Val Gln Ser Leu Glu Ser Met Pro Arg Pro Pro Glu
             250                 255                 260

 cag agg ccg cag ccc agg ccc agt gct cgg cca tgg ccc ctt ggg ctc     1111
 Gln Arg Pro Gln Pro Arg Pro Ser Ala Arg Pro Trp Pro Leu Gly Leu
         265                 270                 275

 ccg ggg ccc gcg ctg ctc ttc ttc ctc ctg tgg ccc ttc gtc gtc cag     1159
 Pro Gly Pro Ala Leu Leu Phe Phe Leu Leu Trp Pro Phe Val Val Gln
     280                 285                 290

 tgg ctc ttc cga atg ttt cgg acc caa aag agg tgactgtc agtggagggg     1210
 Trp Leu Phe Arg Met Phe Arg Thr Gln Lys Arg 
 295                 300                 305

 tctctgcagc caactgagac tatcttgctg tgccctgagc cttcctaggg tttagaagaa   1270

 cagcattcaa aattccccgt cctgtcagtg tttgccttcg cacctcctcc cctaaagcag   1330

 cgcggggggc aaataagacc ccacccctcc ctgcagcttc acagggacgc ttccttccct   1390

 ccccgcaacc accccaggct cccctgggag gctgcagttg tggtacacgt ccccggtgct   1450

 gggttggccg tgactcgggg gcggggcgat cgggtctcag cccctgcctt ccccagtctc   1510

 tgggtcaccc gaattttccc acccctgctt ctccccgagg aggttgagct cttgagcaag   1570

 ttgggacttg ggccggggcc tggaagaatg attggctggg aggccgcggg agggaggcca   1630

 ggaggcccgg accagttggg aggagtgagc aggccccggg ggagggggat gagcgcagtt   1690

 tgctcgcttt cctcccctgc cggccccctc cgcccccaca cacactcggg acgtcttcat   1750

 tgaagattca cttacaaagg aatgtttcac taaataaaag aaaaccagaa aaaaaaaaaa   1810

 aaaa                                                                1814




      <210> 165
      <211> 997
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (151)..(909)

      <400> 165
 taagcttgcg gccgccccga cgcttccgtt cggtccgtcg gcacgtcggc cctgcctccc     60

 ggaccaccct gcggggcgca ccagcgatct ggggtgcggg gctcggcctc cctgcgctcc    120

 tggctgacgg tgtgaccttg ggtcttaacc     atg aac ttc tct gga gga ggg     171
                                      Met Asn Phe Ser Gly Gly Gly
                                        1               5

 agg cag gaa gca gca ggg tcc agg ggt aga agg gct ccc aga ccc cga      219
 Arg Gln Glu Ala Ala Gly Ser Arg Gly Arg Arg Ala Pro Arg Pro Arg
          10                  15                  20

 gaa cag gac cga gac gtg cag ctg tcc aag gct ctg tcc tat gcc ctg      267
 Glu Gln Asp Arg Asp Val Gln Leu Ser Lys Ala Leu Ser Tyr Ala Leu
      25                  30                  35

 cgc cat ggg gcc ttg aag ctg ggg ctt ccc atg gga gct gat ggc ttc      315
 Arg His Gly Ala Leu Lys Leu Gly Leu Pro Met Gly Ala Asp Gly Phe
  40                  45                  50                  55

 gtg ccc ctg ggc acc ctc ctg cag ttg ccc cag ttc cgc ggc ttc tct      363
 Val Pro Leu Gly Thr Leu Leu Gln Leu Pro Gln Phe Arg Gly Phe Ser
                  60                  65                  70

 gct gaa gat gtg cag cgc gtg gtg gac acc aat agg aag cag cgg ttc      411
 Ala Glu Asp Val Gln Arg Val Val Asp Thr Asn Arg Lys Gln Arg Phe
              75                  80                  85

 gcc ctg cag ctg ggg gat ccc agc act ggc ctt ctc atc cgg gcc aac      459
 Ala Leu Gln Leu Gly Asp Pro Ser Thr Gly Leu Leu Ile Arg Ala Asn
          90                  95                 100

 cag ggc cat tcc ctg cag gta cct aag ttg gag ctg atg ccc ctg gag      507
 Gln Gly His Ser Leu Gln Val Pro Lys Leu Glu Leu Met Pro Leu Glu
     105                 110                 115

 aca ccg cag gcc ctg ccc ccg atg cta gtc cat ggt aca ttc tgg aag      555
 Thr Pro Gln Ala Leu Pro Pro Met Leu Val His Gly Thr Phe Trp Lys
 120                 125                 130                 135

 cac tgg cca tcc atc cta ctc aaa ggc ctg tcc tgc cag gga agg acg      603
 His Trp Pro Ser Ile Leu Leu Lys Gly Leu Ser Cys Gln Gly Arg Thr
                 140                 145                 150

 cac att cac ctg gcc cca gga ctg cct gga gac ccc ggt atc atc agt      651
 His Ile His Leu Ala Pro Gly Leu Pro Gly Asp Pro Gly Ile Ile Ser
             155                 160                 165

 ggc atg cgg tcc cat tgt gaa ata gct gtg ttc atc gat gga ccc ctg      699
 Gly Met Arg Ser His Cys Glu Ile Ala Val Phe Ile Asp Gly Pro Leu
         170                 175                 180

 gct ctg gca gat gga ata ccc ttc ttc cgc tct gcc aat ggg gtg att      747
 Ala Leu Ala Asp Gly Ile Pro Phe Phe Arg Ser Ala Asn Gly Val Ile
     185                 190                 195

 ctg act cca ggg aat act gat ggc ttc ctc ctt ccc aag tac ttc aag      795
 Leu Thr Pro Gly Asn Thr Asp Gly Phe Leu Leu Pro Lys Tyr Phe Lys
 200                 205                 210                 215

 gag gcc ctg cag cta cgc cct acc cga aag ccc ctt tcc ttg gct ggt      843
 Glu Ala Leu Gln Leu Arg Pro Thr Arg Lys Pro Leu Ser Leu Ala Gly
                 220                 225                 230

 gat gaa gag aca gag tgt cag agt agc ccc aag cac agc tcc aga gaa      891
 Asp Glu Glu Thr Glu Cys Gln Ser Ser Pro Lys His Ser Ser Arg Glu
             235                 240                 245

 agg agg agg atc caa caa taaaat attaatttat aaaaaagaaa ttttaaaaag      945
 Arg Arg Arg Ile Gln Gln 
         250

 taacaagaaa gaactcgttt gaaaccatgt ttcatcaaaa aaaaaaaaaa aa            997




      <210> 166
      <211> 1062
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(947)

      <400> 166
 agaaggctac atgtgacgag aatgattctg tttcaaatat agccacagaa ataaaggagg     60

 gacaacaatc tgggacagtg tctcctcaga aacaatcggc ccagaaggtt atatttaaaa    120

 agaaagtttc tcttttgaat attgccacaa gaata   atg ggc ggt ggg aaa tct     173
                                          Met Gly Gly Gly Lys Ser
                                            1               5

 gga aca gtg tct tct cag aaa caa cca gcc tca aag act gca agt gac      221
 Gly Thr Val Ser Ser Gln Lys Gln Pro Ala Ser Lys Thr Ala Ser Asp
              10                  15                  20

 aag aca gat tct gct ttg aat aca gct aca gaa ata aag gat gga cta      269
 Lys Thr Asp Ser Ala Leu Asn Thr Ala Thr Glu Ile Lys Asp Gly Leu
          25                  30                  35

 caa tgt ggg aca gtg tct tct cag aaa caa caa gcc ttg aag gct aca      317
 Gln Cys Gly Thr Val Ser Ser Gln Lys Gln Gln Ala Leu Lys Ala Thr
      40                  45                  50

 act gac gag gaa ggt tct gtt tct aat ata gcc aca gaa ata aag gat      365
 Thr Asp Glu Glu Gly Ser Val Ser Asn Ile Ala Thr Glu Ile Lys Asp
  55                  60                  65                  70

 gga gaa aaa tct ggg aca gtg tct tct cag aaa aaa cca gcc ttg aag      413
 Gly Glu Lys Ser Gly Thr Val Ser Ser Gln Lys Lys Pro Ala Leu Lys
                  75                  80                  85

 gcc aca agt gat gag aaa gat tct ttt tcg aat ata acc aga gaa aaa      461
 Ala Thr Ser Asp Glu Lys Asp Ser Phe Ser Asn Ile Thr Arg Glu Lys
              90                  95                 100

 aag gat gga gaa ata tct agg aca gtg tct tct cag aaa cca cca gcc      509
 Lys Asp Gly Glu Ile Ser Arg Thr Val Ser Ser Gln Lys Pro Pro Ala
         105                 110                 115

 ttg aag gct aca agt gtc aag gaa gat tct gtt ttg aat ata gcc aga      557
 Leu Lys Ala Thr Ser Val Lys Glu Asp Ser Val Leu Asn Ile Ala Arg
     120                 125                 130

 gaa aaa aag gat gga gaa aaa tct agg aca gtg tct ttt gac caa cca      605
 Glu Lys Lys Asp Gly Glu Lys Ser Arg Thr Val Ser Phe Asp Gln Pro
 135                 140                 145                 150

 cca ggc ttg aag gct aca aga gac gag aaa gat tct ctt ttg aat ata      653
 Pro Gly Leu Lys Ala Thr Arg Asp Glu Lys Asp Ser Leu Leu Asn Ile
                 155                 160                 165

 gcc aga gga aaa gag gat gga gaa aaa act agg aga gtg tct tct cgg      701
 Ala Arg Gly Lys Glu Asp Gly Glu Lys Thr Arg Arg Val Ser Ser Arg
             170                 175                 180

 aaa aaa cca gcc ttg aag gct aca agt gat gag aaa gat tct ttt tcg      749
 Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Lys Asp Ser Phe Ser
         185                 190                 195

 aat ata acc aga gaa aaa aag gat gga gaa aca tct agg aca gtg tct      797
 Asn Ile Thr Arg Glu Lys Lys Asp Gly Glu Thr Ser Arg Thr Val Ser
     200                 205                 210

 tct cag aaa cca cca gcc ttg aag gct aca agt gac gag gaa gat tct      845
 Ser Gln Lys Pro Pro Ala Leu Lys Ala Thr Ser Asp Glu Glu Asp Ser
 215                 220                 225                 230

 gtt ttg agt ata gcc aga gaa gaa aag gat gga gaa aaa tct agg aca      893
 Val Leu Ser Ile Ala Arg Glu Glu Lys Asp Gly Glu Lys Ser Arg Thr
                 235                 240                 245

 gtg tct tct gag caa cca cca ggc ttg aag tgt ctt ctc gga aaa aag      941
 Val Ser Ser Glu Gln Pro Pro Gly Leu Lys Cys Leu Leu Gly Lys Lys
             250                 255                 260

 cag cct tgaaggctac aagtgatgag aaagattctt tttcaaatat aaccagagaa       997
 Gln Pro 


 agaaaggatg gagaaacatc taggacagtg tcttctcaga aaccaccagc cttgaaggct   1057

 acaag                                                               1062




      <210> 167
      <211> 1270
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (274)..(1170)

      <400> 167
 tcatcacccg tagcatccgg ttaagaggct ctccacctcg ctcattttgg tctaactgga     60

 tttacacaaa ctcactgtgc acgtgcctgg ggcgggcaaa cccggaaacg acgccgagtc    120

 ccgcgggatc caggaggagc caactgcgcc ggaggagggg tttcggccga cacgtcggga    180

 ttggcggctg cagccagggg tcctccgacg ctgggcttcc gtgagcggcg ctctgccaga    240

 tctctggacc ggattcgtcc cattctcgtc ctc atg gtg gac aag aaa ctg gtg     294
                                      Met Val Asp Lys Lys Leu Val
                                        1               5

 gtg gtt ttc gga ggc aca ggt gcc cag ggt ggc tcc gtg gcc cgc aca      342
 Val Val Phe Gly Gly Thr Gly Ala Gln Gly Gly Ser Val Ala Arg Thr
          10                  15                  20

 ctc ctg gaa gat ggg aca ttc aag gtt cga gtg gtg acc cga aac cct      390
 Leu Leu Glu Asp Gly Thr Phe Lys Val Arg Val Val Thr Arg Asn Pro
      25                  30                  35

 agg aag aag gca gca aag gag ctg agg ctg caa ggt gca gaa gta gtg      438
 Arg Lys Lys Ala Ala Lys Glu Leu Arg Leu Gln Gly Ala Glu Val Val
  40                  45                  50                  55

 cag gga gac caa gat gac cag gtc atc atg gag ctg gcc ctg aat ggg      486
 Gln Gly Asp Gln Asp Asp Gln Val Ile Met Glu Leu Ala Leu Asn Gly
                  60                  65                  70

 gct tac gcc acc ttc atc gtg acc aat tac tgg gag agc tgc agc cag      534
 Ala Tyr Ala Thr Phe Ile Val Thr Asn Tyr Trp Glu Ser Cys Ser Gln
              75                  80                  85

 gag cag gag gtc aag cag ggg aag ctg ctc gct gat ctg gcc agg cgc      582
 Glu Gln Glu Val Lys Gln Gly Lys Leu Leu Ala Asp Leu Ala Arg Arg
          90                  95                 100

 ctg ggc ctc cac tat gtg gtc tac agc ggc ctg gag aac atc aag aag      630
 Leu Gly Leu His Tyr Val Val Tyr Ser Gly Leu Glu Asn Ile Lys Lys
     105                 110                 115

 ctg acg gca ggg aga ttg gcc gcc gcg cac ttt gac ggc aaa ggg gag      678
 Leu Thr Ala Gly Arg Leu Ala Ala Ala His Phe Asp Gly Lys Gly Glu
 120                 125                 130                 135

 gtg gag gaa tat ttc cgg gac att ggc gtt ccc atg acc agt gtg cgg      726
 Val Glu Glu Tyr Phe Arg Asp Ile Gly Val Pro Met Thr Ser Val Arg
                 140                 145                 150

 ctg ccc tgc tat ttt gag aac ctc ctc tcc cac ttc ttg ccc cag aaa      774
 Leu Pro Cys Tyr Phe Glu Asn Leu Leu Ser His Phe Leu Pro Gln Lys
             155                 160                 165

 gcc cca gac gga aag agc tac ttg ctg agc ttg ccc aca ggt gac gtt      822
 Ala Pro Asp Gly Lys Ser Tyr Leu Leu Ser Leu Pro Thr Gly Asp Val
         170                 175                 180

 ccc atg gat ggc atg tcc gtg tct gac ctg ggt cct gtg gtg ctc agc      870
 Pro Met Asp Gly Met Ser Val Ser Asp Leu Gly Pro Val Val Leu Ser
     185                 190                 195

 ctt ttg aag atg cca gaa aaa tac gtc ggc cag aac atc ggg ctg agc      918
 Leu Leu Lys Met Pro Glu Lys Tyr Val Gly Gln Asn Ile Gly Leu Ser
 200                 205                 210                 215

 act tgc agg cac acg gcc gag gag tac gct gcc ctg ctc acc aag cac      966
 Thr Cys Arg His Thr Ala Glu Glu Tyr Ala Ala Leu Leu Thr Lys His
                 220                 225                 230

 acc cgc aag gtc gtg cac gat gcc aag atg act cct gag gac tac gaa     1014
 Thr Arg Lys Val Val His Asp Ala Lys Met Thr Pro Glu Asp Tyr Glu
             235                 240                 245

 aag ctt ggc ttt ccc ggt gcc cgg gac ctg gcc aac atg ttc cgt ttc     1062
 Lys Leu Gly Phe Pro Gly Ala Arg Asp Leu Ala Asn Met Phe Arg Phe
         250                 255                 260

 tat gcc ctg aga ccc gac cgt gac atc gag ctg acc ctg aga ctc aac     1110
 Tyr Ala Leu Arg Pro Asp Arg Asp Ile Glu Leu Thr Leu Arg Leu Asn
     265                 270                 275

 ccc aag gcc ctg acg ctg gac cag tgg ctg gaa cag cac aaa ggg gac     1158
 Pro Lys Ala Leu Thr Leu Asp Gln Trp Leu Glu Gln His Lys Gly Asp
 280                 285                 290                 295

 ttc aac ctg ctg tga cctgcccgcc tcgcggcccc ttgtggggat cgggggcacc     1213
 Phe Asn Leu Leu 


 agaggggcag aggcaccaac atctgaataa agccattgtt ctcccaaaaa aaaaaaa      1270




      <210> 168
      <211> 3053
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (454)..(2799)

      <220>
      <221> misc_feature
      <222> (1)...(3053)
      <223> n = a,t,c or g

      <400> 168
 gggaaacgga caacattcgt tttgagcaaa agaagtagag tatatctgca atactgaaga     60

 aaaaaatgtt ctttaaaact atgaagtggt taatgggatt aaagtattca aggaatgaga    120

 tggaaatcct ggtaatgggt agaaacatag gtaaattctc ctttcccact taccaccaac    180

 ctgtgtgaac aacaatcatt tctcattaat agtcaagaat gtgaagagat catgagtana    240

 aagtcttgat cagaaattgt gtatagctgt gtccagcata aaaccttata taaaatgcat    300

 attcatagaa gatgctcaag tatgtcatga aaaatatgaa gtttatttaa atatttatcc    360

 aaattaaaga tttnctgtat tctctaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagcct    420

 cgtgccgaat tcggcacgag ggctgtcgcc acc atg gct ccg cac cgc ccc gcg     474
                                      Met Ala Pro His Arg Pro Ala
                                        1               5

 ccc gcg ctg ctt tgc gcg ctg tcc ctg gcg ctg tgc gcg ctg tcg ctg      522
 Pro Ala Leu Leu Cys Ala Leu Ser Leu Ala Leu Cys Ala Leu Ser Leu
          10                  15                  20

 ccc gtc cgc gcg gcc act gcg tcg cgg ggg gcg tcc cag gcg ggg gcg      570
 Pro Val Arg Ala Ala Thr Ala Ser Arg Gly Ala Ser Gln Ala Gly Ala
      25                  30                  35

 ccc cag ggg cgg gtg ccc gag gcg cgg ccc aac agc atg gtg gtg gaa      618
 Pro Gln Gly Arg Val Pro Glu Ala Arg Pro Asn Ser Met Val Val Glu
  40                  45                  50                  55

 cac ccc gag ttc ctc aag gca ggg aag gag cct ggc ctg cag atc tgg      666
 His Pro Glu Phe Leu Lys Ala Gly Lys Glu Pro Gly Leu Gln Ile Trp
                  60                  65                  70

 cgt gtg gag aag ttc gat ctg gtg ccc gtg ccc acc aac ctt tat gga      714
 Arg Val Glu Lys Phe Asp Leu Val Pro Val Pro Thr Asn Leu Tyr Gly
              75                  80                  85

 gac ttc ttc acg ggc gac gcc tac gtc atc ctg aag aca gtg cag ctg      762
 Asp Phe Phe Thr Gly Asp Ala Tyr Val Ile Leu Lys Thr Val Gln Leu
          90                  95                 100

 agg aac gga aat ctg cag tat gac ctc cac tac tgg ctg ggc aat gag      810
 Arg Asn Gly Asn Leu Gln Tyr Asp Leu His Tyr Trp Leu Gly Asn Glu
     105                 110                 115

 tgc agc cag gat gag agc ggg gcg gcc gcc atc ttt acc gtg cag ctg      858
 Cys Ser Gln Asp Glu Ser Gly Ala Ala Ala Ile Phe Thr Val Gln Leu
 120                 125                 130                 135

 gat gac tac ctg aac ggc cgg gcc gtg cag cac cgt gag gtc cag ggc      906
 Asp Asp Tyr Leu Asn Gly Arg Ala Val Gln His Arg Glu Val Gln Gly
                 140                 145                 150

 ttc gag tcg gcc acc ttc cta ggc tac ttc aag tct ggc ctg aag tac      954
 Phe Glu Ser Ala Thr Phe Leu Gly Tyr Phe Lys Ser Gly Leu Lys Tyr
             155                 160                 165

 aag aaa gga ggt gtg gca tca gga ttc aag cac gtg gta ccc aac gag     1002
 Lys Lys Gly Gly Val Ala Ser Gly Phe Lys His Val Val Pro Asn Glu
         170                 175                 180

 gtg gtg gtg cag aga ctc ttc cag gtc aaa ggg cgg cgt gtg gtc cgt     1050
 Val Val Val Gln Arg Leu Phe Gln Val Lys Gly Arg Arg Val Val Arg
     185                 190                 195

 gcc acc gag gta cct gtg tcc tgg gag agc ttc aac aat ggc gac tgc     1098
 Ala Thr Glu Val Pro Val Ser Trp Glu Ser Phe Asn Asn Gly Asp Cys
 200                 205                 210                 215

 ttc atc ctg gac ctg ggc aac aac atc cac cag tgg tgt ggt tcc aac     1146
 Phe Ile Leu Asp Leu Gly Asn Asn Ile His Gln Trp Cys Gly Ser Asn
                 220                 225                 230

 agc aat cgg tat gaa aga ctg aag gcc aca cag gtg tcc aag ggc atc     1194
 Ser Asn Arg Tyr Glu Arg Leu Lys Ala Thr Gln Val Ser Lys Gly Ile
             235                 240                 245

 cgg gac aac gag cgg agt ggc cgg gcc cga gtg cac gtg tct gag gag     1242
 Arg Asp Asn Glu Arg Ser Gly Arg Ala Arg Val His Val Ser Glu Glu
         250                 255                 260

 ggc act gag ccc gag gcg atg ctc cag gtg ctg ggc ccc aag ccg gct     1290
 Gly Thr Glu Pro Glu Ala Met Leu Gln Val Leu Gly Pro Lys Pro Ala
     265                 270                 275

 ctg cct gca ggt acc gag gac acc gcc aag gag gat gcg gcc aac cgc     1338
 Leu Pro Ala Gly Thr Glu Asp Thr Ala Lys Glu Asp Ala Ala Asn Arg
 280                 285                 290                 295

 aag ctg gcc aag ctc tac aag gtc tcc aat ggt gca ggg acc atg tcc     1386
 Lys Leu Ala Lys Leu Tyr Lys Val Ser Asn Gly Ala Gly Thr Met Ser
                 300                 305                 310

 gtc tcc ctc gtg gct gat gag aac ccc ttc gcc cag ggg gcc ctg aag     1434
 Val Ser Leu Val Ala Asp Glu Asn Pro Phe Ala Gln Gly Ala Leu Lys
             315                 320                 325

 tca gag gac tgc ttc atc ctg gac cac ggc aaa gat ggg aaa atc ttt     1482
 Ser Glu Asp Cys Phe Ile Leu Asp His Gly Lys Asp Gly Lys Ile Phe
         330                 335                 340

 gtc tgg aaa ggc aag cag gca aac acg gag gag agg aag gct gcc ctc     1530
 Val Trp Lys Gly Lys Gln Ala Asn Thr Glu Glu Arg Lys Ala Ala Leu
     345                 350                 355

 aaa aca gcc tct gac ttc atc acc aag atg gac tac ccc aag cag act     1578
 Lys Thr Ala Ser Asp Phe Ile Thr Lys Met Asp Tyr Pro Lys Gln Thr
 360                 365                 370                 375

 cag gtc tcg gtc ctt cct gag ggc ggt gag acc cca ctg ttc aag cag     1626
 Gln Val Ser Val Leu Pro Glu Gly Gly Glu Thr Pro Leu Phe Lys Gln
                 380                 385                 390

 ttc ttc aag aac tgg cgg gac cca gac cag aca gat ggc ctg ggc ttg     1674
 Phe Phe Lys Asn Trp Arg Asp Pro Asp Gln Thr Asp Gly Leu Gly Leu
             395                 400                 405

 tcc tac ctt tcc agc cat atc gcc aac gtg gag cgg gtg ccc ttc gac     1722
 Ser Tyr Leu Ser Ser His Ile Ala Asn Val Glu Arg Val Pro Phe Asp
         410                 415                 420

 gcc gcc acc ctg cac acc tcc act gcc atg gcc gcc cag cac ggc atg     1770
 Ala Ala Thr Leu His Thr Ser Thr Ala Met Ala Ala Gln His Gly Met
     425                 430                 435

 gat gac gat ggc aca ggc cag aaa cag atc tgg aga atc gaa ggt tcc     1818
 Asp Asp Asp Gly Thr Gly Gln Lys Gln Ile Trp Arg Ile Glu Gly Ser
 440                 445                 450                 455

 aac aag gtg ccc gtg gac cct gcc aca tat gga cag ttc tat gga ggc     1866
 Asn Lys Val Pro Val Asp Pro Ala Thr Tyr Gly Gln Phe Tyr Gly Gly
                 460                 465                 470

 gac agc tac atc att ctg tac aac tac cgc cat ggt ggc cgc cag ggg     1914
 Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr Arg His Gly Gly Arg Gln Gly
             475                 480                 485

 cag ata atc tat aac tgg cag ggt gcc cag tct acc cag gat gag gtc     1962
 Gln Ile Ile Tyr Asn Trp Gln Gly Ala Gln Ser Thr Gln Asp Glu Val
         490                 495                 500

 gct gca tct gcc atc ctg act gct cag ctg gat gag gag ctg gga ggt     2010
 Ala Ala Ser Ala Ile Leu Thr Ala Gln Leu Asp Glu Glu Leu Gly Gly
     505                 510                 515

 acc cct gtc cag agc cgt gtg gtc caa ggc aag gag ccc gcc cac ctc     2058
 Thr Pro Val Gln Ser Arg Val Val Gln Gly Lys Glu Pro Ala His Leu
 520                 525                 530                 535

 atg agc ctg ttt ggt ggg aag ccc atg atc atc tac aag ggc ggc acc     2106
 Met Ser Leu Phe Gly Gly Lys Pro Met Ile Ile Tyr Lys Gly Gly Thr
                 540                 545                 550

 tcc cgc gag ggc ggg cag aca gcc cct gcc agc acc cgc ctc ttc cag     2154
 Ser Arg Glu Gly Gly Gln Thr Ala Pro Ala Ser Thr Arg Leu Phe Gln
             555                 560                 565

 gtc cgc gcc aac agc gct gga gcc acc cgg gct gtt gag gta ttg cct     2202
 Val Arg Ala Asn Ser Ala Gly Ala Thr Arg Ala Val Glu Val Leu Pro
         570                 575                 580

 aag gct ggt gca ctg aac tcc aac gat gcc ttt gtt ctg aaa acc ccc     2250
 Lys Ala Gly Ala Leu Asn Ser Asn Asp Ala Phe Val Leu Lys Thr Pro
     585                 590                 595

 tca gcc gcc tac ctg tgg gtg ggt aca gga gcc agc gag gca gag aag     2298
 Ser Ala Ala Tyr Leu Trp Val Gly Thr Gly Ala Ser Glu Ala Glu Lys
 600                 605                 610                 615

 acg ggg gcc cag gag ctg ctc agg gtg ctg cgg gcc caa cct gtg cag     2346
 Thr Gly Ala Gln Glu Leu Leu Arg Val Leu Arg Ala Gln Pro Val Gln
                 620                 625                 630

 gtg gca gaa ggc agc gag cca gat ggc ttc tgg gag gcc ctg ggc ggg     2394
 Val Ala Glu Gly Ser Glu Pro Asp Gly Phe Trp Glu Ala Leu Gly Gly
             635                 640                 645

 aag gct gcc tac cgc aca tcc cca cgg ctg aag gac aag aag atg gat     2442
 Lys Ala Ala Tyr Arg Thr Ser Pro Arg Leu Lys Asp Lys Lys Met Asp
         650                 655                 660

 gcc cat cct cct cgc ctc ttt gcc tgc tcc aac aag att gga cgt ttt     2490
 Ala His Pro Pro Arg Leu Phe Ala Cys Ser Asn Lys Ile Gly Arg Phe
     665                 670                 675

 gtg atc gaa gag gtt cct ggt gag ctc atg cag gaa gac ctg gca acg     2538
 Val Ile Glu Glu Val Pro Gly Glu Leu Met Gln Glu Asp Leu Ala Thr
 680                 685                 690                 695

 gat gac gtc atg ctt ctg gac acc tgg gac cag gtc ttt gtc tgg gtt     2586
 Asp Asp Val Met Leu Leu Asp Thr Trp Asp Gln Val Phe Val Trp Val
                 700                 705                 710

 gga aag gat tct caa gaa gaa gaa aag aca gaa gcc ttg act tct gct     2634
 Gly Lys Asp Ser Gln Glu Glu Glu Lys Thr Glu Ala Leu Thr Ser Ala
             715                 720                 725

 aag cgg tac atc gag acg gac cca gcc aat cgg gat cgg cgg acg ccc     2682
 Lys Arg Tyr Ile Glu Thr Asp Pro Ala Asn Arg Asp Arg Arg Thr Pro
         730                 735                 740

 atc acc gtg gtg aag caa ggc ttt gag cct ccc tcc ttt gtg ggc tgg     2730
 Ile Thr Val Val Lys Gln Gly Phe Glu Pro Pro Ser Phe Val Gly Trp
     745                 750                 755

 ttc ctt ggc tgg gat gat gat tac tgg tct gtg gac ccc ttg gac agg     2778
 Phe Leu Gly Trp Asp Asp Asp Tyr Trp Ser Val Asp Pro Leu Asp Arg
 760                 765                 770                 775

 gcc atg gct gag ctg gct gcc tg aggaggggca gggcccaccc atgtcaccgg     2831
 Ala Met Ala Glu Leu Ala Ala 
                 780

 tcagtgcctt ttggaactgt ccttccctca aagaggcctt agagcgagca gagcagctct   2891

 gctatgagtg tgtgtgtgtg tgtgtgttgt ttcttttttt tttttttaca gtatccaaaa   2951

 atagccctgc aaaaattcag agtccttgca aaattgtcta aaatgtcagt gtttgggaaa   3011

 ttaaatccaa taaaaacatt ttgaagtgtg aaaaaaaaaa aa                      3053




      <210> 169
      <211> 1029
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(805)

      <400> 169
 cacgggcttt ccacagcgcg ggggaacggg aggctgcagg  atg gtc aag ctg acg      55
                                              Met Val Lys Leu Thr
                                                1               5

 gcg gag ctg atc gag cag gcg gcg cag tac acc aac gcg gtg cgc gac      103
 Ala Glu Leu Ile Glu Gln Ala Ala Gln Tyr Thr Asn Ala Val Arg Asp
                  10                  15                  20

 cgg gag ctg gac ctc cgg ggg tat aaa att ccc gtc att gaa aat cta      151
 Arg Glu Leu Asp Leu Arg Gly Tyr Lys Ile Pro Val Ile Glu Asn Leu
              25                  30                  35

 ggt gct acg tta gac cag ttt gat gct att gat ttt tct gac aat gag      199
 Gly Ala Thr Leu Asp Gln Phe Asp Ala Ile Asp Phe Ser Asp Asn Glu
          40                  45                  50

 atc agg aaa ctg gat ggt ttt cct ttg ttg aga aga ctg aaa aca ttg      247
 Ile Arg Lys Leu Asp Gly Phe Pro Leu Leu Arg Arg Leu Lys Thr Leu
      55                  60                  65

 tta gtg aac aac aac aga ata tgc cgt ata ggt gag gga ctt gat cag      295
 Leu Val Asn Asn Asn Arg Ile Cys Arg Ile Gly Glu Gly Leu Asp Gln
  70                  75                  80                  85

 gct ctg ccc tgt ctg aca gaa ctc att ctc acc aat aat agt ctc gtg      343
 Ala Leu Pro Cys Leu Thr Glu Leu Ile Leu Thr Asn Asn Ser Leu Val
                  90                  95                 100

 gaa ctg ggt gat ctg gac cct ctg gca tct ctc aaa tcg ctg act tac      391
 Glu Leu Gly Asp Leu Asp Pro Leu Ala Ser Leu Lys Ser Leu Thr Tyr
             105                 110                 115

 cta agt atc cta aga aat ccg gta acc aat aag aag cat tac aga ttg      439
 Leu Ser Ile Leu Arg Asn Pro Val Thr Asn Lys Lys His Tyr Arg Leu
         120                 125                 130

 tat gtg att tat aaa gtt ccg caa gtc aga gta ctg gat ttc cag aaa      487
 Tyr Val Ile Tyr Lys Val Pro Gln Val Arg Val Leu Asp Phe Gln Lys
     135                 140                 145

 gtg aaa cta aaa gag cgt cag gaa gca gag aaa atg ttc aag ggc aaa      535
 Val Lys Leu Lys Glu Arg Gln Glu Ala Glu Lys Met Phe Lys Gly Lys
 150                 155                 160                 165

 cgg ggt gca cag ctt gca aag gat att gcc agg aga agc aaa act ttt      583
 Arg Gly Ala Gln Leu Ala Lys Asp Ile Ala Arg Arg Ser Lys Thr Phe
                 170                 175                 180

 aat cca ggt gct ggt ttg cca act gac aaa aag aaa ggt ggg cca tct      631
 Asn Pro Gly Ala Gly Leu Pro Thr Asp Lys Lys Lys Gly Gly Pro Ser
             185                 190                 195

 cca ggg gat gta gaa gca atc aag aat gcc ata gca aat gct tca act      679
 Pro Gly Asp Val Glu Ala Ile Lys Asn Ala Ile Ala Asn Ala Ser Thr
         200                 205                 210

 ctg gct gaa gtg gag agg ctg aag ggg ttg ctg cag tct ggt cag atc      727
 Leu Ala Glu Val Glu Arg Leu Lys Gly Leu Leu Gln Ser Gly Gln Ile
     215                 220                 225

 cct ggc aga gaa cgc aga tca ggg ccc act gat gat ggt gaa gaa gag      775
 Pro Gly Arg Glu Arg Arg Ser Gly Pro Thr Asp Asp Gly Glu Glu Glu
 230                 235                 240                 245

 atg gaa gaa gac aca gtc aca aac ggg tcc t gagcagtgag gcagatgtat      826
 Met Glu Glu Asp Thr Val Thr Asn Gly Ser 
                 250                 255

 aataataggc cctcttggaa caagtcttgc ttttcgaaca tggtataata gccttgtttg    886

 tgttagcaaa gtggaatcta tcagcattgt tgaaatgctt aagactgctg ctgataattt    946

 tgtaatataa gttttgaaat ctaaatgtca attttctaca aattataaaa ataaactcca   1006

 ctcactatgc taaaaaaaaa aaa                                           1029




      <210> 170
      <211> 2641
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (195)..(1004)

      <400> 170
 cccaggcgca gccaatggga agggtcggag gcatggcaca gccaatggga agggccgggg     60

 caccaaagcc aatgggaagg gccgggagcg cgcggcgcgg gagatttaaa ggctgctgga    120

 gtgaggggtc gcccgtgcac cctgtcccag ccgtcctgtc ctggctgctc gctctgcttc    180

 gctgcgccgc cact  atg ctc tcc ctc cgt gtc ccg ctc gcg ccc atc acg     230
                  Met Leu Ser Leu Arg Val Pro Leu Ala Pro Ile Thr
                    1               5                  10

 gac ccg cag cag ctg cag ctc tcg ccg ctg aag ggg ctc agc ttg gtc      278
 Asp Pro Gln Gln Leu Gln Leu Ser Pro Leu Lys Gly Leu Ser Leu Val
          15                  20                  25

 gac aag gag aac acg ccg ccg gcc ctg agc ggg acc cgc gtc ctg gcc      326
 Asp Lys Glu Asn Thr Pro Pro Ala Leu Ser Gly Thr Arg Val Leu Ala
      30                  35                  40

 agc aag acc gcg agg agg atc ttc cag gag ccc acg gag ccg aaa act      374
 Ser Lys Thr Ala Arg Arg Ile Phe Gln Glu Pro Thr Glu Pro Lys Thr
  45                  50                  55                  60

 aaa gca gct gcc ccc ggc gtg gag gat gag ccg ctg ctg aga gaa aac      422
 Lys Ala Ala Ala Pro Gly Val Glu Asp Glu Pro Leu Leu Arg Glu Asn
                  65                  70                  75

 ccc cgc cgc ttt gtc atc ttc ccc atc gag tac cat gat atc tgg cag      470
 Pro Arg Arg Phe Val Ile Phe Pro Ile Glu Tyr His Asp Ile Trp Gln
              80                  85                  90

 atg tat aag aag gca gag gct tcc ttt tgg acc gcc gag gag gtg gac      518
 Met Tyr Lys Lys Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp
          95                 100                 105

 ctc tcc aag gac att cag cac tgg gaa tcc ctg aaa ccc gag gag aga      566
 Leu Ser Lys Asp Ile Gln His Trp Glu Ser Leu Lys Pro Glu Glu Arg
     110                 115                 120

 tat ttt ata tcc cat gtt ctg gct ttc ttt gca gca agc gat ggc ata      614
 Tyr Phe Ile Ser His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile
 125                 130                 135                 140

 gta aat gaa aac ttg gtg gag cga ttt agc caa gaa gtt cag att aca      662
 Val Asn Glu Asn Leu Val Glu Arg Phe Ser Gln Glu Val Gln Ile Thr
                 145                 150                 155

 gaa gcc cgc tgt ttc tat ggc ttc caa att gcc atg gaa aac ata cat      710
 Glu Ala Arg Cys Phe Tyr Gly Phe Gln Ile Ala Met Glu Asn Ile His
             160                 165                 170

 tct gaa atg tat agt ctt ctt att gac act tac ata aaa gat ccc aaa      758
 Ser Glu Met Tyr Ser Leu Leu Ile Asp Thr Tyr Ile Lys Asp Pro Lys
         175                 180                 185

 gaa agg gaa ttt ctc ttc aat gcc att gaa acg atg cct tgt gtc aag      806
 Glu Arg Glu Phe Leu Phe Asn Ala Ile Glu Thr Met Pro Cys Val Lys
     190                 195                 200

 aag aag gca gac tgg gcc ttg cgc tgg att ggg gac aaa gag gct acc      854
 Lys Lys Ala Asp Trp Ala Leu Arg Trp Ile Gly Asp Lys Glu Ala Thr
 205                 210                 215                 220

 tat ggt gaa cgt gtt gta gcc ttt gct gca gtg gaa ggc att ttc ttt      902
 Tyr Gly Glu Arg Val Val Ala Phe Ala Ala Val Glu Gly Ile Phe Phe
                 225                 230                 235

 tcc ggt tct ttt gcg tcg ata ttc tgg ctc aag aaa cga gga ctg atg      950
 Ser Gly Ser Phe Ala Ser Ile Phe Trp Leu Lys Lys Arg Gly Leu Met
             240                 245                 250

 cct ggc ctc aca ttt tct aat gaa ctt att agc aga gat gag ggg ttt      998
 Pro Gly Leu Thr Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Phe
         255                 260                 265

 aca ctg tgattttgct tgcctgatgt tcaaacacct ggtacacaaa ccatcggagg      1054
 Thr Leu 
     270

 agagagtaag agaaataatt atcaatgctg ttcggataga acaggagttc ctcactgagg   1114

 ccttgcctgt gaagctcatt gggatgaatt gcactctaat gaagcaatac attgagtttg   1174

 tggcagacag acttatgctg gaactgggtt ttagcaaggt tttcagagta gagaacccat   1234

 ttgactttat ggagaatatt tcactggaag gaaagactaa cttctttgag aagagagtag   1294

 gcgagtatca gaggatggga gtgatgtcaa gtccaacaga gaattctttt accttggatg   1354

 ctgacttcta aatgaactga agatgtgccc ttacttggct gatttttttt ttccatctca   1414

 taagaaaaat cagctgaagt gttaccaact agccacacca tgaattgtcc gtaatgttca   1474

 ttaacagcat ctttaaaact gtgtagctac ctcacaacca gtcctgtctg tttatagtgc   1534

 tggtagtatc accttttgcc aaaaggcctg gctggctgtg acttaccata gcagtgacaa   1594

 tggcagtctt ggctttaaag tgaggggtga ccctttagtg agcttagcac agcgggatta   1654

 aacagtcctt taaccagcac agccagttaa aagatgcagc ctcactgctt caacgcagat   1714

 tttaatgttt acttaaatat aaacctggca ctttacaaac aaataaacat tgtttgtact   1774

 cacaaggcga taatagcttg atttatttgg tttctacacc aaatacattc tcctgaccac   1834

 taatgggagc caattcacaa ttcactaagt gactaaagta agttaaactt gtgtagacta   1894

 agcatgtaat ttttaagttt tattttaatg aattaaaata tttgttaacc aactttaaag   1954

 tcagtcctgt gtatacctag atattagtca gttggtgcca gatagaagac aggttgtgtt   2014

 tttatcctgt ggcttgtgta gtgtcctggg attctctgcc ccctctgagt agagtgttgt   2074

 gggataaagg aatctctcag ggcaaggagc ttcttaagtt aaatcactag aaatttaggg   2134

 gtgatctggg ccttcatatg tgtgagaagc cgtttcattt tatttctcac tgtattttcc   2194

 tcaacgtctg gttgatgaga aaaaattctt gaagagtttt catatgtggg agctaaggta   2254

 gtattgtaaa atttcaagtc atccttaaac aaaatgatcc acctaagatc ttgcccctgt   2314

 taagtggtga aatcaactag aggtggttcc tacaagttgt tcattctagt tttgtttggt   2374

 gtaagtaggt tgtgtgagtt aattcattta tatttactat gtctgttaaa tcagaaattt   2434

 tttattatct atgttcttct agattttacc tgtagttcat acttcagtca cccagtgtct   2494

 tattctggca ttgtctaaat ctgagcattg tctaggggga tcttaaactt tagtaggaaa   2554

 ccatgagctg ttaatacagt ttccattcaa atattaattt cagaatgaaa cataattttt   2614

 tttttttttt ttgaaatgga gtctcct                                       2641




      <210> 171
      <211> 280
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(227)

      <400> 171
 actactaaat tcgcggccgc gtcgacctgt gaagaaac    atg gcg gcc gcg acg      53
                                              Met Ala Ala Ala Thr
                                                1               5

 ttg act tcg aaa ttg tac tcc ctg ctg ttc cgc agg acc tcc acc ttc      101
 Leu Thr Ser Lys Leu Tyr Ser Leu Leu Phe Arg Arg Thr Ser Thr Phe
                  10                  15                  20

 gcc ctc acc atc atc gtg ggc gtc atg ttc ttc gag cgc gcc ttc gat      149
 Ala Leu Thr Ile Ile Val Gly Val Met Phe Phe Glu Arg Ala Phe Asp
              25                  30                  35

 caa ggc gcg gac gct atc tac gac cac atc aac gag ggg aag ctg tgg      197
 Gln Gly Ala Asp Ala Ile Tyr Asp His Ile Asn Glu Gly Lys Leu Trp
          40                  45                  50

 aaa cac atc aag cac aag tat gag aac aag t agttccttgg aggcccccat      248
 Lys His Ile Lys His Lys Tyr Glu Asn Lys 
      55                  60

 ccaggccaga aggaccaggt ccacccagca gc                                  280




      <210> 172
      <211> 2769
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (136)..(1032)

      <400> 172
 cagtggcgga attctagcca ccggtgtctc cttctacatc cgcctctgcg ccggctgcca     60

 cccgcgctcc ctccgccgcc gccgccttgc tgctgctcaa agctgctgcc gccccttggg    120

 ctaaaaggtt ttcaa atg gaa cat ttt gat gca tca ctt agt acc tat ttc     171
                  Met Glu His Phe Asp Ala Ser Leu Ser Thr Tyr Phe
                    1               5                  10

 aag gca ttg cta ggc cct cga gat act aga gta aaa gga tgg ttt ctt      219
 Lys Ala Leu Leu Gly Pro Arg Asp Thr Arg Val Lys Gly Trp Phe Leu
          15                  20                  25

 ctg gac aat tat ata ccc aca ttt atc tgc tct gtc ata tat tta cta      267
 Leu Asp Asn Tyr Ile Pro Thr Phe Ile Cys Ser Val Ile Tyr Leu Leu
      30                  35                  40

 att gta tgg ctg gga cca aaa tac atg agg aat aaa cag cca ttc tct      315
 Ile Val Trp Leu Gly Pro Lys Tyr Met Arg Asn Lys Gln Pro Phe Ser
  45                  50                  55                  60

 tgc cgg ggg att tta gtg gtg tat aac ctt gga ctc aca ctg ctg tct      363
 Cys Arg Gly Ile Leu Val Val Tyr Asn Leu Gly Leu Thr Leu Leu Ser
                  65                  70                  75

 ctg tat atg ttc tgt gag tta gta aca gga gta tgg gaa ggc aaa tac      411
 Leu Tyr Met Phe Cys Glu Leu Val Thr Gly Val Trp Glu Gly Lys Tyr
              80                  85                  90

 aac ttc ttc tgt cag ggc aca cgc acc gca gga gaa tca gat atg aag      459
 Asn Phe Phe Cys Gln Gly Thr Arg Thr Ala Gly Glu Ser Asp Met Lys
          95                 100                 105

 att atc cgt gtc ctc tgg tgg tac tac ttc tcc aaa ctc ata gaa ttt      507
 Ile Ile Arg Val Leu Trp Trp Tyr Tyr Phe Ser Lys Leu Ile Glu Phe
     110                 115                 120

 atg gac act ttc ttc ttc atc ctg cgc aag aac aac cac cag atc acg      555
 Met Asp Thr Phe Phe Phe Ile Leu Arg Lys Asn Asn His Gln Ile Thr
 125                 130                 135                 140

 gtc ctg cac gtc tac cac cat gcc tcg atg ctg aac atc tgg tgg ttt      603
 Val Leu His Val Tyr His His Ala Ser Met Leu Asn Ile Trp Trp Phe
                 145                 150                 155

 gtg atg aac tgg gtc ccc tgc ggc cac tct tat ttt ggt gcc aca ctt      651
 Val Met Asn Trp Val Pro Cys Gly His Ser Tyr Phe Gly Ala Thr Leu
             160                 165                 170

 aat agc ttc atc cac gtc ctc atg tac tct tac tat ggt ttg tcg tca      699
 Asn Ser Phe Ile His Val Leu Met Tyr Ser Tyr Tyr Gly Leu Ser Ser
         175                 180                 185

 gtc cct tcc atg cgt cca tac ctc tgg tgg aag aag tac atc act cag      747
 Val Pro Ser Met Arg Pro Tyr Leu Trp Trp Lys Lys Tyr Ile Thr Gln
     190                 195                 200

 ggg cag ctg ctt cag ttt gtg ctg aca atc atc cag acc agc tgc ggg      795
 Gly Gln Leu Leu Gln Phe Val Leu Thr Ile Ile Gln Thr Ser Cys Gly
 205                 210                 215                 220

 gtc atc tgg ccg tgc aca ttc cct ctt ggt tgg ttg tat ttc cag att      843
 Val Ile Trp Pro Cys Thr Phe Pro Leu Gly Trp Leu Tyr Phe Gln Ile
                 225                 230                 235

 gga tac atg att tcc ctg att gct ctc ttc aca aac ttc tac att cag      891
 Gly Tyr Met Ile Ser Leu Ile Ala Leu Phe Thr Asn Phe Tyr Ile Gln
             240                 245                 250

 acc tac aac aag aaa ggg gcc tcc cga agg aaa gac cac ctg aag gac      939
 Thr Tyr Asn Lys Lys Gly Ala Ser Arg Arg Lys Asp His Leu Lys Asp
         255                 260                 265

 cac cag aat ggg tcc atg gct gct gtg aat gga cac acc aac agc ttt      987
 His Gln Asn Gly Ser Met Ala Ala Val Asn Gly His Thr Asn Ser Phe
     270                 275                 280

 tca ccc ctg gaa aac aat gtg aag cca agg aag ctg cgg aag gat tga     1035
 Ser Pro Leu Glu Asn Asn Val Lys Pro Arg Lys Leu Arg Lys Asp 
 285                 290                 295

 agtcaaagaa ttgaaaccct ccaaaccacg tcatctgatt gtaagcacaa tatgagttgt   1095

 gccccaatgc tcgttaacag ctgctgtaac tagtctggcc tacaatagtg tgattcatgt   1155

 aggacttctt tcatcaattc aaaaccccta gaaaacgtat acagattata taagtaggga   1215

 taagatttct aacatttctg ggctctctga cccctgcgct agactgtgga aagggagtat   1275

 tattatagta tacaacactg ctgttgcctt attagttata acatgatagg tgctgaattg   1335

 tgattcacaa tttaaaaaca ctgtaatcca aacttttttt tttaactgta gatcatgcat   1395

 gtgattgtaa atgtaaattt gtacaatgtt gttatggtag agaaacacac atgccttaaa   1455

 atttaaaaag cagggcccaa agcttattag tttaaattag ggtatgtttc aagtttgtat   1515

 taatttgtaa tagctctgtt tagaaaaaat caaagaccat gatttatgaa actaatgtga   1575

 cataatttcc agtgacttgt tgatgtgaaa tcagacacgg caccttcagt tttgtactat   1635

 tggctttgaa tcaagcaggc tcaaatctag tggaacagtc agtttaactt tttaacagat   1695

 cttatttttt tattttgagt gccactatta atgtaaaaag gggggggctc tacagcagtc   1755

 gtgatgaaac ttaaatatat attctttgtc ctcgagattt taggaagggt gtagggtgag   1815

 taggccattt ttaatttctg aagtgctaag tgtttttata cagcaaacaa aaagtcaatt   1875

 ttgctttcca ccagtgcgag agaggatgta tacttttcaa gagagatgat tgcctattta   1935

 ccgtttgaca gagtcccgta gatgagcaat ggggaactgg ttgccagggt ctaaatttgg   1995

 attgatttat gcactgttat ctgttttgac acagatttcc ttgtaaaatg tgcctagttt   2055

 accaaaatta acaaaggggg ggaaaggacc ttagaacttt ttaaggtaaa atcaaatata   2115

 gctacagcat aagagaatcg agaaatttga tagaggtaac ttgtttaatg taaatctaat   2175

 agtacttgta atttctttct gcttagaatc taaagatgtg tttagaacct cttgtttaaa   2235

 aataatagac tgcttatcat aaaatcacat ctcacacatt tgaggcagtg gtcaaacagg   2295

 taaagcctat gatgtgtgtc attttaaagt gtcggaattt agcctctgaa taccttctcc   2355

 attgggggaa agatattctt ggaaccactc atgacatatc ttagaaggtc attgacaatg   2415

 tataaactaa ttgttggttt gatatttatg taaatatcag tttaccatgc tttaattttg   2475

 cacattcgta ctatagggag cctattggtt ctctattagt cttgtgggtt ttctgtttga   2535

 aaaggagtca tggcatctgt ttacatttac cttatcaaac ctagaatgtg tatatttata   2595

 aatgtatgtc ttcattgcta ggtactaatt tgcagatgtc tttacatatt tcaatacaga   2655

 aactataaca ttcaatagtg tgctgtcaaa gtgtgcttag ctcacctgga tatacctaca   2715

 ttgttaaatg tctaaacagt aatcattaaa acatttttga ttaaaaaaaa aaaa         2769


      <210> 173
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 173
 Met Ala Gly Val Gly Ala Gly Pro Leu Arg Ala Met Gly Arg Gln Ala
   1               5                  10                  15    
 Leu Leu Leu Leu Ala Leu Cys Ala Thr Gly Ala Gln Gly Leu Tyr Phe
              20                  25                  30        
 His Ile Gly Glu Thr Glu Lys Arg Cys Phe Ile Glu Glu Ile Pro Asp
          35                  40                  45            
 Glu Thr Met Val Ile Gly Asn Tyr Arg Thr Gln Met Trp Asp Lys Gln
      50                  55                  60                
 Lys Glu Val Phe Leu Pro Ser Thr Pro Gly Leu Gly Met His Val Glu
  65                  70                  75                  80
 Val Lys Asp Pro Asp Gly Lys Val Val Leu Ser Arg Gln Tyr Gly Ser
                  85                  90                  95    
 Glu Gly Arg Phe Thr Phe Thr Ser His Thr Pro Gly Asp His Gln Ile
             100                 105                 110        
 Cys Leu His Ser Asn Ser Thr Arg Met Ala Leu Phe Ala Gly Gly Lys
         115                 120                 125            
 Leu Arg Val His Leu Asp Ile Gln Val Gly Glu His Ala Asn Asn Tyr
     130                 135                 140                
 Pro Glu Ile Ala Ala Lys Asp Lys Leu Thr Glu Leu Gln Leu Arg Ala
 145                 150                 155                 160
 Arg Gln Leu Leu Asp Gln Val Glu Gln Ile Gln Lys Glu Gln Asp Tyr
                 165                 170                 175    
 Gln Arg Tyr Arg Glu Glu Arg Phe Arg Leu Thr Ser Glu Ser Thr Asn
             180                 185                 190        
 Gln Arg Val Leu Trp Trp Ser Ile Ala Gln Thr Val Ile Leu Ile Leu
         195                 200                 205            
 Thr Gly Ile Trp Gln Met Arg His Leu Lys Ser Phe Phe Glu Ala Lys
     210                 215                 220                
 Lys Leu Val
 225        



      <210> 174
      <211> 524
      <212> PRT
      <213> Homo sapiens


      <400> 174
 Met Val Ala Gly Glu Ser Glu Lys Gly Glu Ala Gln Glu Leu Leu Lys
   1               5                  10                  15    
 Thr Arg Leu Asn Gln Gly Ser Gly Pro Thr Leu Gly Thr Gln Ala Ala
              20                  25                  30        
 Ile Phe Lys Thr Ala Met Pro Leu Asn His Arg Glu Asp Arg Ser Gln
          35                  40                  45            
 Glu Ala Ile Ile Thr Cys Ser Glu Asp Phe Arg Val Ser Asn Val Thr
      50                  55                  60                
 Ser Gly Cys Gln Asn Leu Pro Leu Thr Arg Arg Arg Pro Thr Gly Ser
  65                  70                  75                  80
 Cys Val Cys Leu Gly Arg Gly Gly Pro Gly Gly Gly Gly Leu Arg Ala
                  85                  90                  95    
 Gly Ser Arg His Pro Ala Pro Ala Ala Met His Pro Arg Arg Pro Asp
             100                 105                 110        
 Gly Phe Asp Gly Leu Gly Tyr Arg Gly Gly Ala Arg Asp Glu Gln Gly
         115                 120                 125            
 Phe Gly Gly Ala Phe Pro Ala Arg Ser Phe Ser Thr Gly Ser Asp Leu
     130                 135                 140                
 Gly His Trp Val Thr Thr Pro Pro Asp Ile Pro Gly Ser Arg Asn Leu
 145                 150                 155                 160
 His Trp Gly Glu Lys Ser Pro Pro Tyr Gly Val Pro Thr Thr Ser Thr
                 165                 170                 175    
 Pro Tyr Glu Gly Pro Thr Glu Glu Pro Phe Ser Ser Gly Gly Gly Gly
             180                 185                 190        
 Ser Val Gln Gly Gln Ser Ser Glu Gln Leu Asn Arg Phe Ala Gly Phe
         195                 200                 205            
 Gly Ile Gly Leu Ala Ser Leu Phe Thr Glu Asn Val Leu Ala His Pro
     210                 215                 220                
 Cys Ile Val Leu Arg Arg Gln Cys Gln Val Asn Tyr His Ala Gln His
 225                 230                 235                 240
 Tyr His Leu Thr Pro Phe Thr Val Ile Asn Ile Met Tyr Ser Phe Asn
                 245                 250                 255    
 Lys Thr Gln Gly Pro Arg Ala Leu Trp Lys Gly Met Gly Ser Thr Phe
             260                 265                 270        
 Ile Val Gln Gly Val Thr Leu Gly Ala Glu Gly Ile Ile Ser Glu Phe
         275                 280                 285            
 Thr Pro Leu Pro Arg Glu Val Leu His Lys Trp Ser Pro Lys Gln Ile
     290                 295                 300                
 Gly Glu His Leu Leu Leu Lys Ser Leu Thr Tyr Val Val Ala Met Pro
 305                 310                 315                 320
 Phe Tyr Ser Ala Ser Leu Ile Glu Thr Val Gln Ser Glu Ile Ile Arg
                 325                 330                 335    
 Asp Asn Thr Gly Ile Leu Glu Cys Val Lys Glu Gly Ile Gly Arg Val
             340                 345                 350        
 Ile Gly Met Gly Val Pro His Ser Lys Arg Leu Leu Pro Leu Leu Ser
         355                 360                 365            
 Leu Ile Phe Pro Thr Val Leu His Gly Val Leu His Tyr Ile Ile Ser
     370                 375                 380                
 Ser Val Ile Gln Lys Phe Val Leu Leu Ile Leu Lys Arg Lys Thr Tyr
 385                 390                 395                 400
 Asn Ser His Leu Ala Glu Ser Thr Ser Pro Val Gln Ser Met Leu Asp
                 405                 410                 415    
 Ala Tyr Phe Pro Glu Leu Ile Ala Asn Phe Ala Ala Ser Leu Cys Ser
             420                 425                 430        
 Asp Val Ile Leu Tyr Pro Leu Glu Thr Val Leu His Arg Leu His Ile
         435                 440                 445            
 Gln Gly Thr Arg Thr Ile Ile Asp Asn Thr Asp Leu Gly Tyr Glu Val
     450                 455                 460                
 Leu Pro Ile Asn Thr Gln Tyr Glu Gly Met Arg Asp Cys Ile Asn Thr
 465                 470                 475                 480
 Ile Arg Gln Glu Glu Gly Val Phe Gly Phe Tyr Lys Gly Phe Gly Ala
                 485                 490                 495    
 Val Ile Ile Gln Tyr Thr Leu His Ala Ala Val Leu Gln Ile Thr Lys
             500                 505                 510        
 Ile Ile Tyr Ser Thr Leu Leu Gln Asn Asn Ile
         515                 520            



      <210> 175
      <211> 481
      <212> PRT
      <213> Homo sapiens


      <400> 175
 Met Ala Thr Val Pro Gly Leu Gln Pro Leu Pro Thr Leu Glu Gln Asp
   1               5                  10                  15    
 Leu Glu Gln Glu Glu Ile Leu Ile Val Lys Val Glu Glu Asp Phe Cys
              20                  25                  30        
 Leu Glu Glu Glu Pro Ser Val Glu Thr Glu Asp Pro Ser Pro Glu Thr
          35                  40                  45            
 Phe Arg Gln Leu Phe Arg Leu Phe Cys Tyr Gln Glu Val Ala Gly Pro
      50                  55                  60                
 Arg Glu Ala Leu Ser Arg Leu Trp Glu Leu Cys Cys Arg Trp Leu Arg
  65                  70                  75                  80
 Pro Glu Leu Arg Thr Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu
                  85                  90                  95    
 Gln Phe Leu Thr Val Leu Pro Gly Glu Ile Gln Ala Arg Val Arg Glu
             100                 105                 110        
 Gln Gln Pro Glu Ser Gly Glu Glu Ala Val Val Leu Val Glu Gly Leu
         115                 120                 125            
 Gln Arg Lys Pro Arg Lys His Arg Gln Arg Gly Ser Glu Leu Leu Ser
     130                 135                 140                
 Asp Asp Glu Val Pro Leu Gly Ile Gly Gly Gln Phe Leu Lys His Gln
 145                 150                 155                 160
 Ala Glu Ala Gln Pro Glu Asp Leu Ser Leu Glu Glu Glu Ala Arg Phe
                 165                 170                 175    
 Ser Ser Gln Gln Pro Pro Ala Gln Leu Ser His Arg Pro Gln Arg Gly
             180                 185                 190        
 Pro Leu Leu Trp Pro Glu Arg Gly Pro Pro Ala Pro Arg His Gln Glu
         195                 200                 205            
 Met Ala Ser Ala Ser Pro Phe Leu Ser Ala Trp Ser Gln Val Pro Val
     210                 215                 220                
 Asn Leu Glu Asp Val Ala Val Tyr Leu Ser Gly Glu Glu Pro Arg Cys
 225                 230                 235                 240
 Met Asp Pro Ala Gln Arg Asp Ala Pro Leu Glu Asn Glu Gly Pro Gly
                 245                 250                 255    
 Ile Gln Leu Glu Asp Gly Gly Asp Gly Arg Glu Asp Ala Pro Leu Arg
             260                 265                 270        
 Met Glu Trp Tyr Arg Val Leu Ser Ala Arg Cys Gln Gly Pro Gly His
         275                 280                 285            
 Pro Leu Pro Gly Gln Arg Pro Ala Pro Val Arg Gly Leu Val Arg Pro
     290                 295                 300                
 Asp Gln Pro Arg Gly Gly Pro Pro Pro Gly Arg Arg Ala Ser His Gly
 305                 310                 315                 320
 Ala Asp Lys Pro Tyr Thr Cys Pro Glu Cys Gly Lys Gly Phe Ser Lys
                 325                 330                 335    
 Thr Ser His Leu Thr Lys His Gln Arg Thr His Thr Gly Glu Arg Pro
             340                 345                 350        
 Tyr Lys Cys Leu Val Cys Gly Lys Gly Phe Ser Asp Arg Ser Asn Phe
         355                 360                 365            
 Ser Thr His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Pro Cys Pro
     370                 375                 380                
 Glu Cys Gly Lys Arg Phe Ser Gln Ser Ser Ser Leu Val Ile His Arg
 385                 390                 395                 400
 Arg Thr His Ser Gly Glu Arg Pro Tyr Ala Cys Thr Gln Cys Gly Lys
                 405                 410                 415    
 Arg Phe Asn Asn Ser Ser His Phe Ser Ala His Arg Arg Thr His Thr
             420                 425                 430        
 Gly Glu Lys Pro Tyr Thr Cys Pro Ala Cys Gly Arg Gly Phe Arg Arg
         435                 440                 445            
 Gly Thr Asp Leu His Lys His Gln Arg Thr His Met Gly Ala Gly Ser
     450                 455                 460                
 Leu Pro Thr Leu Gln Pro Val Ala Pro Gly Gly Pro Gly Ala Lys Ala
 465                 470                 475                 480





      <210> 176
      <211> 1820
      <212> PRT
      <213> Homo sapiens


      <400> 176
 Met His Gly Lys Asp Gln Arg Leu Val Arg Ser Gln His Val Glu Gly
   1               5                  10                  15    
 Cys Cys Lys Arg Ile Gly Phe Asp Gly Gly Ser Gln Leu Val Ile Val
              20                  25                  30        
 Asn Phe Pro Trp Pro Ala Ile Met Leu Leu Ile Phe Phe Ile Met Leu
          35                  40                  45            
 Leu Ile Phe Phe Ala Lys Pro Phe Glu Pro Pro Leu Cys Leu Ser Met
      50                  55                  60                
 Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala Gly Gly
  65                  70                  75                  80
 Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala Asp Ser Glu Val
                  85                  90                  95    
 Arg Ala Leu Ser Pro Ala Gly His Pro Phe His Ser Asp Lys Cys Asp
             100                 105                 110        
 Leu Gly Glu Lys Gln Pro Glu Glu Cys Glu Lys Ser Leu Lys Gly Ile
         115                 120                 125            
 Gln Asn Arg Ala Glu Trp Glu Val Asp Leu Val Ser Ser Glu Leu Leu
     130                 135                 140                
 Lys Asp His Cys Asp Val Arg Lys Arg Ala Gly Arg Asn Glu Lys Leu
 145                 150                 155                 160
 Gln Glu Pro Asp Thr Ala Phe Ser Pro Ser Ser Leu Phe Phe Lys Asn
                 165                 170                 175    
 Pro Leu Asn Leu Ser His Arg Ile Ser Lys Ser Lys Phe Ser Arg Tyr
             180                 185                 190        
 Trp Arg Arg Trp Asn Arg Phe Cys Arg Arg Lys Cys Arg Ala Ala Val
         195                 200                 205            
 Lys Ser Asn Val Phe Tyr Trp Leu Val Ile Phe Leu Val Phe Leu Asn
     210                 215                 220                
 Thr Leu Thr Ile Ala Ser Glu His Tyr Asn Gln Pro Asn Trp Leu Thr
 225                 230                 235                 240
 Glu Val Gln Asp Thr Ala Asn Lys Ala Leu Leu Ala Leu Phe Thr Ala
                 245                 250                 255    
 Glu Met Leu Leu Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val
             260                 265                 270        
 Ser Leu Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu
         275                 280                 285            
 Glu Thr Ile Leu Val Glu Thr Lys Ile Met Ser Pro Leu Gly Ile Ser
     290                 295                 300                
 Val Leu Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Ile Thr Arg Tyr
 305                 310                 315                 320
 Trp Asn Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Val Arg
                 325                 330                 335    
 Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe
             340                 345                 350        
 Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu
         355                 360                 365            
 Met Gln Thr Arg Arg Ser Thr Phe Asp Asn Phe Pro Gln Ser Leu Leu
     370                 375                 380                
 Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ser Val Met Tyr
 385                 390                 395                 400
 Asp Gly Ile Met Ala Tyr Gly Gly Pro Ser Phe Pro Gly Met Leu Val
                 405                 410                 415    
 Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Cys Ile Leu Cys
             420                 425                 430        
 Cys Cys Pro Pro Pro Leu Arg Pro Pro Ala Pro Ser Leu Gln His Ser
         435                 440                 445            
 Ala Lys Arg Ala Arg Pro Ser Glu Trp Thr Gln Thr Asp Ile Leu Leu
     450                 455                 460                
 Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser
 465                 470                 475                 480
 Leu Thr Ser Ala Gln Lys Glu Glu Glu Glu Glu Lys Glu Arg Lys Lys
                 485                 490                 495    
 Leu Ala Arg Thr Ala Ser Pro Glu Lys Lys Gln Glu Leu Val Glu Lys
             500                 505                 510        
 Pro Ala Val Gly Glu Ser Lys Glu Glu Lys Ile Glu Leu Lys Ser Ile
         515                 520                 525            
 Thr Ala Asp Gly Glu Ser Pro Pro Ala Thr Lys Ile Asn Met Asp Asp
     530                 535                 540                
 Leu Gln Pro Asn Glu Asn Glu Asp Lys Ser Pro Tyr Pro Asn Pro Glu
 545                 550                 555                 560
 Thr Thr Gly Glu Glu Asp Glu Glu Glu Pro Glu Met Pro Val Gly Pro
                 565                 570                 575    
 Arg Pro Arg Pro Leu Ser Glu Leu His Leu Lys Glu Lys Ala Val Pro
             580                 585                 590        
 Met Pro Glu Ala Ser Ala Phe Phe Ile Phe Ser Ser Asn Asn Arg Phe
         595                 600                 605            
 Arg Leu Gln Cys His Arg Ile Val Asn Asp Thr Ile Phe Thr Asn Leu
     610                 615                 620                
 Ile Leu Phe Phe Ile Leu Leu Ser Ser Ile Ser Leu Ala Ala Glu Asp
 625                 630                 635                 640
 Pro Val Gln His Thr Ser Phe Arg Asn His Ile Leu Phe Tyr Phe Asp
                 645                 650                 655    
 Ile Val Phe Thr Thr Ile Phe Thr Ile Glu Ile Ala Leu Lys Ile Leu
             660                 665                 670        
 Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe Thr Leu Glu Ile Ile
         675                 680                 685            
 Leu Lys Asp Thr Gln Val Pro Pro Ala Ala Ile Pro Gly Trp Lys His
     690                 695                 700                
 Pro Ser Lys Gly Pro Phe Pro Ser Asn Gly Val Glu Leu Gly Lys Gln
 705                 710                 715                 720
 Asp Arg Gly Gly Trp Gln Ser Glu Lys Lys Gly Gln Arg Gly Thr Ile
                 725                 730                 735    
 Ser Thr Gly Tyr Leu Ser Leu Ala Phe Pro Asp Ala Leu Asn Thr Thr
             740                 745                 750        
 Asp Asp Phe Gln Met Thr Ala Tyr Gly Ala Phe Leu His Lys Gly Ser
         755                 760                 765            
 Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val Val Ser Val
     770                 775                 780                
 Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn Val Val Lys
 785                 790                 795                 800
 Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg
                 805                 810                 815    
 Ala Lys Gly Leu Lys His Val Val Gln Cys Val Phe Val Ala Ile Arg
             820                 825                 830        
 Thr Ile Gly Asn Ile Val Ile Val Thr Thr Leu Leu Gln Phe Met Phe
         835                 840                 845            
 Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys Leu Tyr Thr Cys Ser
     850                 855                 860                
 Asp Ser Ser Lys Gln Thr Glu Ala Glu Cys Lys Gly Asn Tyr Ile Thr
 865                 870                 875                 880
 Tyr Lys Asp Gly Glu Val Asp His Pro Ile Ile Gln Pro Arg Ser Trp
                 885                 890                 895    
 Glu Asn Ser Lys Phe Asp Phe Asp Asn Val Leu Ala Ala Met Met Ala
             900                 905                 910        
 Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro Asp Met Ser His Asp
         915                 920                 925            
 Val Arg Asp Leu Cys His Tyr Pro Tyr Gly Ile Trp Glu Leu Gly Val
     930                 935                 940                
 Gly Arg Ala Ser Pro Gly Val Gly Pro Val Val Thr Ile Gly Phe Lys
 945                 950                 955                 960
 Ile Ala Thr Pro Ser Met Pro Phe Ile Gly Leu Leu Tyr Arg Ser Ile
                 965                 970                 975    
 Asp Ser His Thr Glu Asp Lys Gly Pro Ile Tyr Asn Tyr Arg Val Glu
             980                 985                 990        
 Ile Ser Ile Phe Phe Ile Ile Tyr Ile Ile Ile Ile Ala Phe Phe Met
         995                1000                1005            
 Met Asn Ile Phe Val Gly Phe Val Ile Val Thr Phe Gln Glu Gln Gly
    1010                1015                1020                
 Glu Gln Glu Tyr Lys Asn Cys Glu Leu Asp Lys Asn Gln Arg Gln Cys
1025                1030                1035                1040
 Val Glu Tyr Ala Leu Lys Ala Arg Pro Leu Arg Arg Tyr Ile Pro Lys
                1045                1050                1055    
 Asn Gln His Gln Tyr Lys Val Trp Tyr Val Val Asn Ser Thr Tyr Phe
            1060                1065                1070        
 Glu Tyr Leu Met Phe Val Leu Ile Leu Leu Asn Thr Ile Cys Leu Ala
        1075                1080                1085            
 Met Gln His Tyr Gly Gln Ser Cys Leu Phe Lys Ile Ala Met Asn Ile
    1090                1095                1100                
 Leu Asn Met Leu Phe Thr Gly Leu Phe Thr Val Glu Met Ile Leu Lys
1105                1110                1115                1120
 Leu Ile Ala Phe Lys Pro Lys Glu Arg Gly Asn Glu Gly Ser Glu Ala
                1125                1130                1135    
 Leu Ala Leu Ser Ala Ser Gln Arg Val Glu Arg Gln Lys Glu Glu Arg
            1140                1145                1150        
 Phe Leu Arg Ser Pro Thr Cys Cys Pro Glu Glu Ser Ile Asn Glu Ala
        1155                1160                1165            
 Leu Gly Thr Ser Phe Ile Glu Ile Val Leu Glu Arg Leu Ser Asp Asp
    1170                1175                1180                
 Val Glu Ala Trp Tyr His Leu Tyr Arg Ala His Arg Val Val Arg Glu
1185                1190                1195                1200
 Thr Pro Ile His Asn Lys Gln Arg Phe Gln Met Gly Ser Leu Ser Leu
                1205                1210                1215    
 Ser Gly Val Val Cys Arg Lys Arg Lys Gln Arg Trp Lys Ala Lys Thr
            1220                1225                1230        
 Val Ala Pro Glu Pro Pro Ser Val Pro Cys Ser Ala Gly Leu Ser Ser
        1235                1240                1245            
 Met Ala Thr Gln Pro Ala Leu Arg Gly Ser Glu Glu Leu Asp Ser Arg
    1250                1255                1260                
 Gly Leu Val Cys His Phe Lys Glu Ser Gln Glu Asn Pro Phe Ser Asn
1265                1270                1275                1280
 Pro Leu Leu Leu Asn His Leu Gly His Ser His Gln Arg Asn Lys Gly
                1285                1290                1295    
 Gln Gln Gly Tyr Phe Ser Asp Pro Trp Asn Val Phe Asp Phe Leu Ile
            1300                1305                1310        
 Val Ile Gly Ser Ile Ile Asp Val Ile Leu Ser Glu Thr Asn Leu Cys
        1315                1320                1325            
 Pro Ala Leu Pro Gly Trp Gly Val Glu Leu Ser Arg Gly Ser Gly Gly
    1330                1335                1340                
 Ala Gly Asp Thr Pro Pro Gly Ser Pro Gly Arg Pro Gln Pro His Ala
1345                1350                1355                1360
 Thr Phe Glu Leu Thr Gln Leu Leu Ser Gly Leu Cys Thr Leu Arg Lys
                1365                1370                1375    
 Pro Gly Tyr Pro Gly Leu Ser Cys Gln Asn Cys Arg Val His Tyr Phe
            1380                1385                1390        
 Cys Asp Ala Trp Asn Thr Phe Asp Ala Leu Ile Val Val Gly Ser Ile
        1395                1400                1405            
 Val Asp Ile Ala Ile Thr Glu Val Asn Met Val Pro Lys Ala Pro Ala
    1410                1415                1420                
 Leu Glu Lys Lys Lys Arg Gln Glu Ala Glu Glu Arg Arg Gly Leu Gly
1425                1430                1435                1440
 Gln Gly Leu Trp Arg Glu Glu Ile Gly Thr Arg Lys Leu Leu Phe Ile
                1445                1450                1455    
 Trp Glu Met Pro Leu Asn Asn Cys Gln Val Ser Gln Glu Asp Arg Leu
            1460                1465                1470        
 Gln Ala Pro Ser Lys Thr Thr Asp Gly Arg Asn Tyr Lys Leu Thr Gln
        1475                1480                1485            
 Gly Thr Gly Ser Lys Ser Gly Lys Gly Ser Glu Ile Asn Gly Pro Ser
    1490                1495                1500                
 Ile Asp Gly Tyr Gln Gln Ile Leu Asn Leu His Pro Lys Asn Ala Glu
1505                1510                1515                1520
 Glu Asn Ser Arg Ile Ser Ile Thr Phe Phe Arg Leu Phe Arg Val Met
                1525                1530                1535    
 Arg Leu Val Lys Leu Leu Ser Arg Gly Glu Gly Ile Arg Thr Leu Leu
            1540                1545                1550        
 Trp Thr Phe Ile Lys Ser Phe Gln Ala Leu Pro Tyr Val Ala Leu Leu
        1555                1560                1565            
 Ile Val Met Leu Phe Phe Ile Tyr Ala Val Ile Gly Met Gln Val Phe
    1570                1575                1580                
 Gly Lys Ile Ala Leu Asn Asp Thr Thr Glu Ile Asn Arg Asn Asn Asn
1585                1590                1595                1600
 Phe Gln Thr Phe Pro Gln Ala Val Leu Leu Leu Phe Arg Cys Ala Thr
                1605                1610                1615    
 Gly Glu Ala Trp Gln Asp Ile Met Leu Ala Cys Met Pro Gly Lys Lys
            1620                1625                1630        
 Cys Ala Pro Glu Ser Glu Pro Ser Asn Ser Thr Glu Gly Glu Thr Pro
        1635                1640                1645            
 Cys Gly Ser Ser Phe Ala Val Phe Tyr Phe Ile Ser Phe Tyr Met Leu
    1650                1655                1660                
 Cys Ala Phe Leu Ile Ile Asn Leu Phe Val Ala Val Ile Met Asp Asn
1665                1670                1675                1680
 Phe Asp Tyr Leu Thr Arg Asp Trp Ser Ile Leu Gly Pro His His Leu
                1685                1690                1695    
 Asp Glu Phe Lys Arg Ile Trp Ala Glu Tyr Asp Pro Glu Ala Lys Gly
            1700                1705                1710        
 Arg Ile Lys His Leu Asp Val Val Thr Leu Leu Arg Arg Ile Gln Pro
        1715                1720                1725            
 Pro Leu Gly Phe Gly Lys Leu Cys Pro His Arg Val Ala Cys Lys Arg
    1730                1735                1740                
 Leu Val Ser Met Asn Met Pro Leu Asn Ser Asp Gly Thr Val Met Phe
1745                1750                1755                1760
 Asn Ala Thr Leu Phe Ala Leu Val Arg Thr Ala Leu Arg Ile Lys Thr
                1765                1770                1775    
 Glu Ala Phe His Glu Thr Leu Gly Leu Ile Leu Gly Gly Ile Leu Lys
            1780                1785                1790        
 Ser Glu Gly Ile Ala His Lys Thr Glu Gly Asp Gly Cys Tyr Leu Lys
        1795                1800                1805            
 Gln Asp Gln Pro Leu Ser Lys Arg Thr Tyr Thr Gly
    1810                1815                1820



      <210> 177
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 177
 Met Leu Phe Cys Leu Cys Leu Leu Phe Ile Val Cys Lys Ile Gly Trp
   1               5                  10                  15    
 Thr Ala Asn Arg Arg Met Arg Ala Ala Gln Pro Gly Leu Thr Phe Phe
              20                  25                  30        
 Gln Leu Ile His Lys Gln Gly Asp Met Gln Gly Ala Glu Gly Pro Trp
          35                  40                  45            
 Asp Val Thr Asn Ser Ala Phe Leu Trp Arg Leu Tyr Asp Gln Thr Ala
      50                  55                  60                
 Asn Cys Leu Ser Arg Met Gln Asp Met Gly Lys Leu Thr Leu Pro Cys
  65                  70                  75                  80
 His Gln Lys Val Cys
                  85



      <210> 178
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 178
 Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val
   1               5                  10                  15    
 Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu
              20                  25                  30        
 Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro
          35                  40                  45            
 Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His
      50                  55                  60                
 His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys
  65                  70                  75                  80
 Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp
                  85                  90                  95    
 Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile
             100                 105                 110        
 Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys
         115                 120                 125            
 Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp
     130                 135                 140                
 Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys
 145                 150                 155                 160
 Glu Glu Lys
            



      <210> 179
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 179
 Met Thr Lys His Pro Pro Asn Arg Arg Gly Ile Ser Phe Glu Val Gly
   1               5                  10                  15    
 Ala Gln Leu Glu Ala Arg Asp Arg Leu Lys Asn Trp Tyr Pro Ala His
              20                  25                  30        
 Ile Glu Asp Ile Asp Tyr Glu Glu Gly Lys Val Leu Ile His Phe Lys
          35                  40                  45            
 Arg Trp Asn His Arg Tyr Asp Glu Trp Phe Cys Trp Asp Ser Pro Tyr
      50                  55                  60                
 Leu Arg Pro Leu Glu Lys Ile Gln Leu Arg Lys Glu Gly Leu His Glu
  65                  70                  75                  80
 Glu Asp Gly Ser Ser Glu Phe Gln Ile Asn Glu Gln Val Leu Ala Cys
                  85                  90                  95    
 Trp Ser Asp Cys Arg Phe Tyr Pro Ala Lys Val Thr Ala Val Asn Lys
             100                 105                 110        
 Asp Gly Thr Tyr Thr Val Lys Phe Tyr Asp Gly Val Val Gln Thr Val
         115                 120                 125            
 Lys His Ile His Val Lys Ala Phe Ser Lys Asp Gln Val Arg Asn Val
     130                 135                 140                
 Val Leu Cys Phe Val Leu
 145                 150



      <210> 180
      <211> 397
      <212> PRT
      <213> Homo sapiens


      <400> 180
 Met Ser Val Ala Phe Ala Ser Ala Arg Pro Arg Gly Lys Gly Glu Val
   1               5                  10                  15    
 Thr Gln Gln Thr Ile Gln Lys Met Leu Asp Glu Asn His His Leu Ile
              20                  25                  30        
 Gln Cys Ile Leu Glu Tyr Gln Ser Lys Gly Lys Thr Ala Glu Cys Thr
          35                  40                  45            
 Gln Tyr Gln Gln Ile Leu His Arg Asn Leu Val Tyr Leu Ala Thr Ile
      50                  55                  60                
 Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro Ala Pro Pro Thr
  65                  70                  75                  80
 Gln Asn Met Asn Leu Gly Pro Gly Ala Leu Thr Gln Ser Gly Ser Ser
                  85                  90                  95    
 Gln Gly Leu His Ser Gln Gly Ser Leu Ser Asp Ala Ile Ser Thr Gly
             100                 105                 110        
 Leu Pro Pro Ser Ser Leu Leu Gln Gly Gln Ile Gly Asn Gly Pro Ser
         115                 120                 125            
 His Val Ser Met Gln Gln Thr Ala Pro Asn Thr Leu Pro Thr Thr Ser
     130                 135                 140                
 Met Ser Ile Ser Gly Pro Gly Tyr Ser His Ala Gly Pro Ala Ser Gln
 145                 150                 155                 160
 Gly Val Pro Met Gln Gly Gln Gly Thr Ile Gly Asn Tyr Val Ser Arg
                 165                 170                 175    
 Thr Asn Ile Asn Met Gln Ser Asn Pro Val Ser Met Met Gln Gln Gln
             180                 185                 190        
 Ala Ala Thr Ser His Tyr Ser Ser Ala Gln Gly Gly Ser Gln His Tyr
         195                 200                 205            
 Gln Gly Gln Ser Ser Ile Ala Met Met Gly Gln Gly Ser Gln Gly Ser
     210                 215                 220                
 Ser Met Met Gly Gln Arg Pro Met Ala Pro Tyr Arg Pro Ser Gln Gln
 225                 230                 235                 240
 Gly Ser Ser Gln Gln Tyr Leu Gly Gln Glu Glu Tyr Tyr Gly Glu Gln
                 245                 250                 255    
 Tyr Ser His Ser Gln Gly Ala Ala Glu Pro Met Gly Gln Gln Tyr Tyr
             260                 265                 270        
 Pro Asp Gly His Gly Asp Tyr Ala Tyr Gln Gln Ser Ser Tyr Thr Glu
         275                 280                 285            
 Gln Ser Tyr Asp Arg Ser Phe Glu Glu Ser Thr Gln His Tyr Tyr Glu
     290                 295                 300                
 Gly Gly Asn Ser Gln Tyr Ser Gln Gln Gln Ala Gly Tyr Gln Gln Gly
 305                 310                 315                 320
 Ala Ala Gln Gln Gln Thr Tyr Ser Gln Gln Gln Tyr Pro Ser Gln Gln
                 325                 330                 335    
 Ser Tyr Pro Gly Gln Gln Gln Gly Tyr Gly Ser Ala Gln Gly Ala Pro
             340                 345                 350        
 Ser Gln Tyr Pro Gly Tyr Gln Gln Gly Gln Gly Gln Gln Tyr Gly Ser
         355                 360                 365            
 Tyr Arg Ala Pro Gln Thr Ala Pro Ser Ala Gln Gln Gln Arg Pro Tyr
     370                 375                 380                
 Gly Tyr Glu Gln Gly Gln Tyr Gly Asn Tyr Gln Gln
 385                 390                 395    



      <210> 181
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 181
 Met Glu Lys Leu Leu Lys Leu Asp Val Asn Ala Ser Arg Gln Gly Ile
   1               5                  10                  15    
 Glu Asp Ala Glu Glu Thr Ala Thr Gln Thr Cys Gly Gly Thr Asp Ser
              20                  25                  30        
 Thr Glu Gly Leu Phe Asn Met Asp Glu Asp Glu Glu Thr Glu His Glu
          35                  40                  45            
 Thr Lys Ala Gly Pro Glu Arg Leu Asp Gln Met Val His Pro Val Ala
      50                  55                  60                
 Glu Arg Leu Asp Ile Leu Met Ser Leu Val Leu Ser Tyr Met Lys Asp
  65                  70                  75                  80
 Val Cys Tyr Val Asp Gly Lys Val Asp Asn Gly Lys Thr Lys Asp Leu
                  85                  90                  95    
 Tyr Arg Asp Leu Ile Asn Ile Phe Asp Lys Leu Leu Leu Pro Thr His
             100                 105                 110        
 Ala Ser Cys His Val Gln Phe Phe Met Phe Tyr Leu Cys Ser Phe Lys
         115                 120                 125            
 Leu Gly Phe Ala Glu Ala Phe Leu Glu His Leu Trp Lys Lys Leu Gln
     130                 135                 140                
 Asp Pro Ser Asn Pro Ala Ile Ile Arg Gln Ala Ala Gly Asn Tyr Ile
 145                 150                 155                 160
 Gly Ser Phe Leu Ala Arg Ala Lys Phe Ile Pro Leu Ile Thr Val Lys
                 165                 170                 175    
 Ser Cys Leu Asp Leu Leu Val Asn Trp Leu His Ile Tyr Leu Asn Asn
             180                 185                 190        
 Gln Asp Ser Gly Thr Lys Ala Phe Cys Asp Val Ala Leu His Gly Pro
         195                 200                 205            
 Phe Tyr Ser Ala Cys Gln Ala Val Phe Tyr Thr Phe Val Phe Arg His
     210                 215                 220                
 Lys Gln Leu Leu Ser Gly Asn Leu Lys Glu Gly Leu Gln Tyr Leu Gln
 225                 230                 235                 240
 Ser Leu Asn Phe Glu Arg Ile Val Met Ser Gln Leu Asn Pro Leu Lys
                 245                 250                 255    
 Ile Cys Leu Pro Ser Val Val Asn Phe Phe Ala Ala Ile Thr Asn Lys
             260                 265                 270        
 Tyr Gln Leu Val Phe Cys Tyr Thr Ile Ile Glu Arg Asn Asn Arg Gln
         275                 280                 285            
 Met Leu Pro Val Ile Arg Ser Thr Thr Gly Gly Asp Ser Val Gln Thr
     290                 295                 300                
 Cys Thr Asn Pro Leu Asp Thr Phe Val Pro Phe Asp Pro Cys Val Leu
 305                 310                 315                 320
 Lys Arg Pro Ala Phe Arg Leu Leu Pro
                 325                



      <210> 182
      <211> 81
      <212> PRT
      <213> Homo sapiens


      <400> 182
 Met Ala Pro Lys Ala Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu Ala
   1               5                  10                  15    
 Lys Ala Lys Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val Arg
              20                  25                  30        
 Ser His Thr Gln Lys Arg Gly Ser Ala Cys His Ser Pro Ser Gly Gly
          35                  40                  45            
 Pro Arg His Cys Asp Ser Gly Gly Ser Pro Asp Ile Leu Arg Arg Ala
      50                  55                  60                
 Pro Pro Gly Glu Thr Ser Leu Ala Thr Met Leu Ser Ser Ser Phe Arg
  65                  70                  75                  80





      <210> 183
      <211> 930
      <212> PRT
      <213> Homo sapiens


      <400> 183
 Met Thr Lys Lys Arg Lys Arg Gln His Asp Phe Gln Lys Val Lys Leu
   1               5                  10                  15    
 Lys Val Gly Lys Lys Lys Pro Lys Leu Gln Asn Ala Thr Pro Thr Asn
              20                  25                  30        
 Phe Lys Thr Lys Thr Ile His Leu Pro Glu Gln Leu Lys Glu Asp Gly
          35                  40                  45            
 Thr Leu Pro Thr Asn Asn Arg Lys Leu Asn Ile Lys Asp Leu Leu Ser
      50                  55                  60                
 Gln Met His His Tyr Asn Ala Gly Val Lys Gln Ser Ala Leu Leu Gly
  65                  70                  75                  80
 Leu Lys Asp Leu Leu Ser Gln Tyr Pro Phe Ile Ile Asp Ala His Leu
                  85                  90                  95    
 Ser Asn Ile Leu Ser Glu Val Thr Ala Val Phe Thr Asp Lys Asp Ala
             100                 105                 110        
 Asn Val Arg Leu Ala Ala Val Gln Leu Leu Gln Phe Leu Ala Pro Lys
         115                 120                 125            
 Ile Arg Ala Glu Gln Ile Ser Pro Phe Phe Pro Leu Val Ser Ala His
     130                 135                 140                
 Leu Ser Ser Ala Met Thr His Ile Thr Glu Gly Ile Gln Glu Asp Ser
 145                 150                 155                 160
 Leu Lys Val Leu Asp Ile Leu Leu Glu Gln Tyr Pro Ala Leu Ile Thr
                 165                 170                 175    
 Gly Arg Ser Ser Ile Leu Leu Lys Asn Phe Val Glu Leu Ile Ser His
             180                 185                 190        
 Gln Gln Leu Ser Lys Gly Leu Ile Asn Arg Asp Arg Ser Gln Ser Trp
         195                 200                 205            
 Ile Leu Ser Val Asn Pro Asn Arg Arg Leu Thr Ser Gln Gln Trp Arg
     210                 215                 220                
 Leu Lys Val Leu Val Arg Leu Ser Lys Phe Leu Gln Ala Leu Ala Asp
 225                 230                 235                 240
 Gly Ser Ser Arg Leu Arg Glu Ser Glu Gly Leu Gln Glu Gln Lys Glu
                 245                 250                 255    
 Asn Pro His Ala Thr Ser Asn Ser Ile Phe Ile Asn Trp Lys Glu His
             260                 265                 270        
 Ala Asn Asp Gln Gln His Ile Gln Val Tyr Glu Asn Gly Gly Ser Gln
         275                 280                 285            
 Pro Asn Val Ser Ser Gln Phe Arg Leu Arg Tyr Leu Val Gly Gly Leu
     290                 295                 300                
 Ser Gly Val Asp Glu Gly Leu Ser Ser Thr Glu Asn Leu Lys Gly Phe
 305                 310                 315                 320
 Ile Glu Ile Ile Ile Pro Leu Leu Ile Glu Cys Trp Val Glu Ala Val
                 325                 330                 335    
 Pro Pro Gln Leu Ala Thr Pro Val Gly Asn Gly Ile Glu Arg Glu Pro
             340                 345                 350        
 Leu Gln Val Met Gln Gln Val Leu Asn Ile Ile Ser Leu Leu Trp Lys
         355                 360                 365            
 Leu Ser Lys Gln Gln Asp Glu Thr His Lys Leu Glu Ser Trp Leu Arg
     370                 375                 380                
 Lys Asn Tyr Leu Ile Asp Phe Lys His His Phe Met Ser Arg Phe Pro
 385                 390                 395                 400
 Tyr Val Leu Lys Glu Ile Thr Lys His Lys Arg Lys Glu Pro Asn Lys
                 405                 410                 415    
 Ser Ile Lys His Cys Thr Val Leu Ser Asn Asn Ile Asp His Leu Leu
             420                 425                 430        
 Leu Asn Leu Thr Leu Ser Asp Ile Met Val Ser Leu Ala Asn Ala Ser
         435                 440                 445            
 Thr Leu Gln Lys Asp Cys Ser Trp Ile Glu Met Ile Arg Lys Phe Val
     450                 455                 460                
 Thr Glu Thr Leu Glu Asp Gly Ser Arg Leu Asn Ser Lys Gln Leu Asn
 465                 470                 475                 480
 Arg Leu Leu Gly Val Ser Trp Arg Leu Met Gln Ile Gln Pro Asn Arg
                 485                 490                 495    
 Glu Asp Thr Glu Thr Leu Ile Lys Ala Val Tyr Thr Leu Tyr Gln Gln
             500                 505                 510        
 Arg Gly Leu Ile Leu Pro Val Arg Thr Leu Leu Leu Lys Phe Phe Ser
         515                 520                 525            
 Lys Ile Tyr Gln Thr Glu Glu Leu Arg Ser Cys Arg Phe Arg Tyr Arg
     530                 535                 540                
 Ser Lys Val Leu Ser Arg Trp Leu Ala Gly Leu Pro Leu Gln Leu Ala
 545                 550                 555                 560
 His Leu Gly Ser Arg Asn Pro Glu Leu Ser Thr Gln Leu Ile Asp Ile
                 565                 570                 575    
 Ile His Thr Ala Ala Ala Arg Ala Asn Lys Glu Leu Leu Lys Ser Leu
             580                 585                 590        
 Gln Ala Thr Ala Leu Arg Ile Tyr Asp Pro Gln Glu Gly Ala Val Val
         595                 600                 605            
 Val Leu Pro Ala Asp Ser Gln Gln Arg Leu Val Gln Leu Val Tyr Phe
     610                 615                 620                
 Leu Pro Ser Leu Pro Ala Asp Leu Leu Ser Arg Leu Ser Arg Cys Cys
 625                 630                 635                 640
 Ile Met Gly Arg Leu Ser Ser Ser Leu Ala Ala Met Leu Ile Gly Ile
                 645                 650                 655    
 Leu His Met Arg Ser Ser Phe Ser Gly Trp Lys Tyr Ser Ala Lys Asp
             660                 665                 670        
 Trp Leu Met Ser Asp Val Asp Tyr Phe Ser Phe Leu Phe Ser Thr Leu
         675                 680                 685            
 Thr Gly Phe Ser Lys Glu Glu Leu Thr Trp Leu Gln Ser Leu Arg Gly
     690                 695                 700                
 Val Pro His Val Ile Gln Thr Gln Leu Ser Pro Val Leu Leu Tyr Leu
 705                 710                 715                 720
 Thr Asp Leu Asp Gln Phe Leu His His Trp Asp Val Thr Glu Ala Val
                 725                 730                 735    
 Phe His Ser Leu Leu Val Ile Pro Ala Arg Ser Gln Asn Phe Asp Ile
             740                 745                 750        
 Leu Gln Ser Ala Ile Ser Lys His Leu Val Gly Leu Thr Val Ile Pro
         755                 760                 765            
 Asp Ser Thr Ala Gly Cys Val Phe Gly Val Ile Cys Lys Leu Leu Asp
     770                 775                 780                
 His Thr Cys Val Val Ser Glu Thr Leu Leu Pro Phe Leu Ala Ser Cys
 785                 790                 795                 800
 Cys Tyr Ser Leu Leu Tyr Phe Leu Leu Thr Ile Glu Lys Gly Glu Ala
                 805                 810                 815    
 Glu His Leu Arg Lys Arg Asp Lys Leu Trp Gly Val Cys Val Ser Ile
             820                 825                 830        
 Leu Ala Leu Leu Pro Arg Val Leu Arg Leu Met Leu Gln Ser Leu Arg
         835                 840                 845            
 Val Asn Arg Val Gly Pro Glu Glu Leu Pro Val Val Gly Gln Leu Leu
     850                 855                 860                
 Arg Leu Leu Leu Gln His Ala Pro Leu Arg Thr His Met Leu Thr Asn
 865                 870                 875                 880
 Ala Ile Leu Val Gln Gln Ile Ile Lys Asn Ile Thr Thr Leu Lys Ser
                 885                 890                 895    
 Gly Ser Val Gln Glu Gln Trp Leu Thr Asp Leu His Tyr Cys Phe Asn
             900                 905                 910        
 Val Tyr Ile Thr Gly His Pro Gln Gly Pro Ser Ala Leu Ala Thr Val
         915                 920                 925            
 Tyr
    



      <210> 184
      <211> 576
      <212> PRT
      <213> Homo sapiens


      <400> 184
 Met Asp Pro Glu Asp Glu Gly Val Ala Gly Val Met Ser Val Gly Pro
   1               5                  10                  15    
 Pro Ala Ala Arg Leu Gln Glu Pro Val Thr Phe Arg Asp Val Ala Val
              20                  25                  30        
 Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Asp Pro Thr Gln Arg Ile
          35                  40                  45            
 Leu Tyr Arg Asp Val Met Leu Glu Thr Phe Gly His Leu Leu Ser Ile
      50                  55                  60                
 Gly Pro Glu Leu Pro Lys Pro Glu Val Ile Ser Gln Leu Glu Gln Gly
  65                  70                  75                  80
 Thr Glu Leu Trp Val Ala Glu Arg Gly Thr Thr Gln Gly Cys His Pro
                  85                  90                  95    
 Ala Trp Glu Pro Arg Ser Glu Ser Gln Ala Ser Arg Lys Glu Glu Gly
             100                 105                 110        
 Leu Pro Glu Glu Glu Pro Ser His Val Thr Gly Arg Glu Gly Phe Pro
         115                 120                 125            
 Thr Asp Ala Pro Tyr Pro Thr Thr Leu Gly Lys Asp Arg Glu Cys Gln
     130                 135                 140                
 Ser Gln Ser Leu Ala Leu Lys Glu Gln Asn Asn Leu Lys Gln Leu Glu
 145                 150                 155                 160
 Phe Gly Leu Lys Glu Ala Pro Val Gln Asp Gln Gly Tyr Lys Thr Leu
                 165                 170                 175    
 Arg Leu Arg Glu Asn Cys Val Leu Ser Ser Ser Pro Asn Pro Phe Pro
             180                 185                 190        
 Glu Ile Ser Arg Gly Glu Tyr Leu Tyr Thr Tyr Asp Ser Gln Ile Thr
         195                 200                 205            
 Asp Ser Glu His Asn Ser Ser Leu Val Ser Gln Gln Thr Gly Ser Pro
     210                 215                 220                
 Gly Lys Gln Pro Gly Glu Asn Ser Asp Cys His Arg Asp Ser Ser Gln
 225                 230                 235                 240
 Ala Ile Pro Ile Thr Glu Leu Thr Lys Ser Gln Val Gln Asp Lys Pro
                 245                 250                 255    
 Tyr Lys Cys Thr Asp Cys Gly Lys Ser Phe Asn His Asn Ala His Leu
             260                 265                 270        
 Thr Val His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr Met Cys Lys
         275                 280                 285            
 Glu Cys Gly Lys Ala Phe Ser Gln Asn Ser Ser Leu Val Gln His Glu
     290                 295                 300                
 Arg Ile His Thr Gly Asp Lys Pro Tyr Lys Cys Ala Glu Cys Gly Lys
 305                 310                 315                 320
 Ser Phe Cys His Ser Thr His Leu Thr Val His Arg Arg Ile His Thr
                 325                 330                 335    
 Gly Glu Lys Pro Tyr Glu Cys Gln Asp Cys Gly Arg Ala Phe Asn Gln
             340                 345                 350        
 Asn Ser Ser Leu Gly Arg His Lys Arg Thr His Thr Gly Glu Lys Pro
         355                 360                 365            
 Tyr Thr Cys Ser Val Cys Gly Lys Ser Phe Ser Arg Thr Thr Cys Leu
     370                 375                 380                
 Phe Leu His Leu Arg Thr His Thr Glu Glu Arg Pro Tyr Glu Cys Asn
 385                 390                 395                 400
 His Cys Gly Lys Gly Phe Arg His Ser Ser Ser Leu Ala Gln His Gln
                 405                 410                 415    
 Arg Lys His Ala Gly Glu Lys Pro Phe Glu Cys Arg Gln Arg Leu Ile
             420                 425                 430        
 Phe Glu Gln Thr Pro Ala Leu Thr Lys His Glu Trp Thr Glu Ala Leu
         435                 440                 445            
 Gly Cys Asp Pro Pro Leu Ser Gln Asp Glu Arg Thr His Arg Ser Asp
     450                 455                 460                
 Arg Pro Phe Lys Cys Asn Gln Cys Gly Lys Cys Phe Ile Gln Ser Ser
 465                 470                 475                 480
 His Leu Ile Arg His Gln Ile Thr His Thr Arg Glu Glu Gln Pro His
                 485                 490                 495    
 Gly Arg Ser Arg Arg Arg Glu Gln Ser Ser Ser Arg Asn Ser His Leu
             500                 505                 510        
 Val Gln His Gln His Pro Asn Ser Arg Lys Ser Ser Ala Gly Gly Ala
         515                 520                 525            
 Lys Ala Gly Gln Pro Glu Ser Arg Ala Leu Ala Leu Phe Asp Ile Gln
     530                 535                 540                
 Lys Ile Met Gln Glu Lys Asn Pro Val His Val Ile Gly Val Glu Glu
 545                 550                 555                 560
 Pro Ser Val Gly Ala Ser Met Leu Phe Asp Ile Arg Glu Ser Thr
                 565                 570                 575



      <210> 185
      <211> 485
      <212> PRT
      <213> Homo sapiens


      <400> 185
 Met Ile Val Ser Tyr Asp Glu His Glu Val Asn Asn Thr Phe Lys Phe
   1               5                  10                  15    
 Gly Val Ile Tyr Gln Lys Ala Arg Gln Thr Leu Glu Glu Glu Leu Phe
              20                  25                  30        
 Gly Asn Asn Glu Glu Ser Pro Ala Phe Lys Glu Phe Leu Asp Leu Leu
          35                  40                  45            
 Gly Asp Thr Ile Thr Leu Gln Asp Phe Lys Gly Phe Arg Gly Gly Leu
      50                  55                  60                
 Asp Val Thr His Gly Gln Thr Gly Val Glu Ser Val Tyr Thr Thr Phe
  65                  70                  75                  80
 Arg Asp Arg Glu Ile Met Phe His Val Ser Thr Lys Leu Pro Phe Thr
                  85                  90                  95    
 Asp Gly Asp Ala Gln Gln Leu Gln Arg Lys Arg His Ile Gly Asn Asp
             100                 105                 110        
 Ile Val Ala Ile Ile Phe Gln Glu Glu Asn Thr Pro Phe Val Pro Asp
         115                 120                 125            
 Met Ile Ala Ser Asn Phe Leu His Ala Tyr Ile Val Val Gln Val Glu
     130                 135                 140                
 Thr Pro Gly Thr Glu Thr Pro Ser Tyr Lys Val Ser Val Thr Ala Arg
 145                 150                 155                 160
 Glu Asp Val Pro Thr Phe Gly Pro Pro Leu Pro Ser Pro Pro Val Phe
                 165                 170                 175    
 Gln Lys Gly Pro Glu Phe Arg Glu Phe Leu Leu Thr Lys Leu Thr Asn
             180                 185                 190        
 Ala Glu Asn Ala Cys Cys Lys Ser Asp Lys Phe Ala Lys Leu Glu Asp
         195                 200                 205            
 Arg Thr Arg Ala Ala Leu Leu Asp Asn Leu His Asp Glu Leu His Ala
     210                 215                 220                
 His Thr Gln Ala Met Leu Gly Leu Gly Pro Glu Glu Asp Lys Phe Glu
 225                 230                 235                 240
 Asn Gly Gly His Gly Gly Phe Leu Glu Ser Phe Lys Arg Ala Ile Arg
                 245                 250                 255    
 Val Arg Ser His Ser Met Glu Thr Met Val Gly Gly Gln Lys Lys Ser
             260                 265                 270        
 His Ser Gly Gly Ile Pro Gly Ser Leu Ser Gly Gly Ile Ser His Asn
         275                 280                 285            
 Ser Met Glu Val Thr Lys Thr Thr Phe Ser Pro Pro Val Val Ala Ala
     290                 295                 300                
 Thr Val Lys Asn Gln Ser Arg Ser Pro Ile Lys Arg Arg Ser Gly Leu
 305                 310                 315                 320
 Phe Pro Arg Leu His Thr Gly Ser Glu Gly Gln Gly Asp Ser Arg Ala
                 325                 330                 335    
 Arg Cys Asp Ser Thr Ser Ser Thr Pro Lys Thr Pro Asp Gly Gly His
             340                 345                 350        
 Ser Ser Gln Glu Ile Lys Ser Glu Thr Ser Ser Asn Pro Ser Ser Pro
         355                 360                 365            
 Glu Ile Cys Pro Asn Lys Glu Lys Pro Phe Met Lys Leu Lys Glu Asn
     370                 375                 380                
 Gly Arg Ala Ile Ser Arg Ser Ser Ser Ser Thr Ser Ser Val Ser Ser
 385                 390                 395                 400
 Thr Ala Gly Glu Gly Glu Ala Met Glu Glu Gly Asp Ser Gly Gly Ser
                 405                 410                 415    
 Gln Pro Ser Thr Thr Ser Pro Phe Lys Gln Glu Val Phe Val Tyr Ser
             420                 425                 430        
 Pro Ser Pro Ser Ser Glu Ser Pro Ser Leu Gly Ala Ala Ala Thr Pro
         435                 440                 445            
 Ile Ile Met Ser Arg Ser Pro Thr Asp Ala Lys Ser Arg Asn Ser Pro
     450                 455                 460                
 Arg Ser Asn Leu Lys Phe Arg Phe Asp Lys Leu Ser His Ala Ser Ser
 465                 470                 475                 480
 Gly Ala Gly His
                



      <210> 186
      <211> 363
      <212> PRT
      <213> Homo sapiens


      <400> 186
 Met Ala Ser Gly Asp Phe Cys Ser Pro Gly Glu Gly Met Glu Ile Leu
   1               5                  10                  15    
 Gln Gln Val Cys Ser Lys Gln Leu Pro Pro Cys Asn Leu Ser Lys Glu
              20                  25                  30        
 Asp Leu Leu Gln Asn Pro Tyr Phe Ser Lys Leu Leu Leu Asn Leu Ser
          35                  40                  45            
 Gln His Val Asp Glu Ser Gly Leu Ser Leu Thr Leu Ala Lys Glu Gln
      50                  55                  60                
 Ala Gln Ala Trp Lys Glu Val Arg Leu His Lys Thr Thr Trp Leu Arg
  65                  70                  75                  80
 Ser Glu Ile Leu His Arg Val Ile Gln Glu Leu Leu Val Asp Tyr Tyr
                  85                  90                  95    
 Val Lys Ile Gln Asp Thr Asn Val Thr Ser Glu Asp Lys Lys Phe His
             100                 105                 110        
 Glu Thr Leu Glu Gln Arg Leu Leu Val Thr Glu Leu Met Arg Leu Leu
         115                 120                 125            
 Gly Pro Ser Gln Glu Arg Glu Ile Pro Pro Leu Leu Gly Leu Glu Lys
     130                 135                 140                
 Ala Asp Leu Leu Glu Leu Met Pro Leu Ser Glu Asp Phe Val Trp Met
 145                 150                 155                 160
 Arg Ala Arg Leu Gln Gln Glu Val Glu Glu Gln Leu Lys Lys Lys Cys
                 165                 170                 175    
 Phe Thr Leu Leu Cys Tyr Tyr Asp Pro Asn Ser Asp Ala Asp Ser Glu
             180                 185                 190        
 Thr Val Lys Ala Ala Lys Val Trp Lys Leu Ala Glu Val Leu Val Gly
         195                 200                 205            
 Glu Gln Gln Gln Cys Gln Asp Ala Lys Ser Gln Gln Lys Glu Gln Met
     210                 215                 220                
 Leu Leu Leu Glu Lys Lys Ser Ala Ala Tyr Ser Gln Val Leu Leu Arg
 225                 230                 235                 240
 Cys Leu Thr Leu Leu Gln Arg Leu Leu Gln Glu His Arg Leu Lys Thr
                 245                 250                 255    
 Gln Ser Glu Leu Asp Arg Ile Asn Ala Gln Tyr Leu Glu Val Lys Cys
             260                 265                 270        
 Gly Ala Met Ile Leu Lys Leu Arg Met Glu Glu Leu Lys Ile Leu Ser
         275                 280                 285            
 Asp Thr Tyr Thr Val Glu Lys Val Glu Val His Arg Leu Ile Arg Asp
     290                 295                 300                
 Arg Leu Glu Gly Ala Ile His Leu Gln Glu Gln Asp Met Glu Asn Ser
 305                 310                 315                 320
 Arg Gln Val Leu Asn Ser Tyr Glu Val Leu Gly Glu Glu Phe Asp Arg
                 325                 330                 335    
 Leu Val Lys Glu Tyr Thr Val Leu Lys Gln Ala Thr Glu Asn Lys Arg
             340                 345                 350        
 Trp Ala Leu Gln Glu Phe Ser Lys Val Tyr Arg
         355                 360            



      <210> 187
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 187
 Met Asn Val Lys Val Gly Arg Trp Ser Gln Val Val Phe Arg Pro Phe
   1               5                  10                  15    
 Ile Cys Lys Gln Leu Phe Tyr Leu Cys Val Tyr Leu Ser Val Cys Leu
              20                  25                  30        
 Ser Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu
          35                  40                  45            
 Ser Ile Tyr Leu Ser Ile Tyr Leu Phe Tyr Phe Leu Arg Trp Ser Leu
      50                  55                  60                
 Ala Leu Ser Ser Glu Leu Glu Cys Ser Gly Val Ile Ser Ala His Cys
  65                  70                  75                  80
 Lys Leu Arg Leu Pro Gly Ser Thr Asn Ser Pro Thr Ser Ala Ser
                  85                  90                  95



      <210> 188
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 188
 Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp Ala Leu
   1               5                  10                  15    
 Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp Thr Phe
              20                  25                  30        
 Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala Trp Gln
          35                  40                  45            
 Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val Leu Glu
      50                  55                  60                
 Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg Lys Gln
  65                  70                  75                  80
 Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys Ala Lys
                  85                  90                  95    
 Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu Asp Leu
             100                 105                 110        
 Lys Tyr Asp Pro Asp Pro Ala Pro His Met Glu Asn Leu Lys Cys Arg
         115                 120                 125            
 Gly Glu Thr Val Ala Lys Glu Ile Ser Glu Ala Met Lys Ser Leu Pro
     130                 135                 140                
 Ala Leu Ile Glu Gln Gly Glu Gly Phe Ser Gln Val Leu Arg Met Gln
 145                 150                 155                 160
 Pro Val Ile His Leu Gln Arg Ile His Gln Glu Val Phe Ser Ser Cys
                 165                 170                 175    
 His Arg Lys Pro Asp Ala Lys Pro Glu Asn Phe Ile Thr Gln Ile Glu
             180                 185                 190        
 Thr Thr Pro Thr Glu Thr Ala Ser Arg Lys Thr Ser Asp Met Val Leu
         195                 200                 205            
 Lys Arg Lys Gln Thr Lys Asp Cys Pro Gln Arg Lys Trp Tyr Pro Leu
     210                 215                 220                
 Arg Pro Lys Lys Ile Asn Leu Asp Thr
 225                 230            



      <210> 189
      <211> 214
      <212> PRT
      <213> Homo sapiens


      <400> 189
 Met His Gln Gln Lys Arg Gln Pro Glu Leu Val Glu Gly Asn Leu Pro
   1               5                  10                  15    
 Val Phe Val Phe Pro Thr Glu Leu Ile Phe Tyr Ala Asp Asp Gln Ser
              20                  25                  30        
 Thr His Lys Gln Val Leu Thr Leu Tyr Asn Pro Tyr Glu Phe Ala Leu
          35                  40                  45            
 Lys Phe Lys Val Leu Cys Thr Thr Pro Asn Lys Tyr Val Val Val Asp
      50                  55                  60                
 Ala Ala Gly Ala Val Lys Pro Gln Cys Cys Val Asp Ile Val Ile Arg
  65                  70                  75                  80
 His Arg Asp Val Arg Ser Cys His Tyr Gly Val Ile Asp Lys Phe Arg
                  85                  90                  95    
 Leu Gln Val Ser Glu Gln Ser Gln Arg Lys Ala Leu Gly Arg Lys Glu
             100                 105                 110        
 Val Val Ala Thr Leu Leu Pro Ser Ala Lys Glu Gln Gln Lys Glu Glu
         115                 120                 125            
 Glu Glu Lys Arg Leu Lys Glu His Leu Thr Glu Ser Leu Phe Phe Glu
     130                 135                 140                
 Gln Ser Phe Gln Pro Glu Asn Arg Ala Val Ser Ser Gly Pro Ser Leu
 145                 150                 155                 160
 Leu Thr Val Phe Leu Gly Val Val Cys Ile Ala Ala Leu Met Leu Pro
                 165                 170                 175    
 Thr Leu Gly Asp Val Glu Ser Leu Val Pro Leu Tyr Leu His Leu Ser
             180                 185                 190        
 Val Asn Gln Lys Leu Val Ala Ala Tyr Ile Leu Gly Leu Ile Thr Met
         195                 200                 205            
 Ala Ile Leu Arg Thr
     210            



      <210> 190
      <211> 475
      <212> PRT
      <213> Homo sapiens


      <400> 190
 Met Ile Ser Phe Cys Pro Asp Cys Gly Lys Ser Ile Gln Ala Ala Phe
   1               5                  10                  15    
 Lys Phe Cys Pro Tyr Cys Gly Asn Ser Leu Pro Val Glu Glu His Val
              20                  25                  30        
 Gly Ser Gln Thr Phe Val Asn Pro His Val Ser Ser Phe Gln Gly Ser
          35                  40                  45            
 Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys
      50                  55                  60                
 Trp Ser Ser Thr Val Thr Ser Pro Arg Leu Ser Leu Phe Ser Asp Gly
  65                  70                  75                  80
 Asp Ser Ser Glu Ser Glu Asp Thr Leu Ser Ser Ser Glu Arg Ser Lys
                  85                  90                  95    
 Gly Ser Gly Ser Arg Pro Pro Thr Pro Lys Ser Ser Pro Gln Lys Thr
             100                 105                 110        
 Arg Lys Ser Pro Gln Val Thr Arg Gly Ser Pro Gln Lys Thr Ser Cys
         115                 120                 125            
 Ser Pro Gln Lys Thr Arg Gln Ser Pro Gln Thr Leu Lys Arg Ser Arg
     130                 135                 140                
 Val Thr Thr Ser Leu Glu Ala Leu Pro Thr Gly Thr Val Leu Thr Asp
 145                 150                 155                 160
 Lys Ser Gly Arg Gln Trp Lys Leu Lys Ser Phe Gln Thr Arg Asp Asn
                 165                 170                 175    
 Gln Gly Ile Leu Tyr Glu Ala Ala Pro Thr Ser Thr Leu Thr Cys Asp
             180                 185                 190        
 Ser Gly Pro Gln Lys Gln Lys Phe Ser Leu Lys Leu Asp Ala Lys Asp
         195                 200                 205            
 Gly Arg Leu Phe Asn Glu Gln Asn Phe Phe Gln Arg Ala Ala Lys Pro
     210                 215                 220                
 Leu Gln Val Asn Lys Trp Lys Lys Leu Tyr Ser Thr Pro Leu Leu Ala
 225                 230                 235                 240
 Ile Pro Thr Cys Met Gly Phe Gly Val His Gln Asp Lys Tyr Arg Phe
                 245                 250                 255    
 Leu Val Leu Pro Ser Leu Gly Arg Ser Leu Gln Ser Ala Leu Asp Val
             260                 265                 270        
 Ser Pro Lys His Val Leu Ser Glu Arg Ser Val Leu Gln Val Ala Cys
         275                 280                 285            
 Arg Leu Leu Asp Ala Leu Glu Phe Leu His Glu Asn Glu Tyr Val His
     290                 295                 300                
 Gly Asn Val Thr Ala Glu Asn Ile Phe Val Asp Pro Glu Asp Gln Ser
 305                 310                 315                 320
 Gln Val Thr Leu Ala Gly Tyr Gly Phe Ala Phe Arg Tyr Cys Pro Ser
                 325                 330                 335    
 Gly Lys His Val Ala Tyr Val Glu Gly Ser Arg Ser Pro His Glu Gly
             340                 345                 350        
 Asp Leu Glu Phe Ile Ser Met Asp Leu His Lys Gly Cys Gly Pro Ser
         355                 360                 365            
 Arg Arg Ser Asp Leu Gln Ser Leu Gly Tyr Cys Met Leu Lys Trp Leu
     370                 375                 380                
 Tyr Gly Phe Leu Pro Trp Thr Asn Cys Leu Pro Asn Thr Glu Asp Ile
 385                 390                 395                 400
 Met Lys Gln Lys Gln Lys Phe Val Asp Lys Pro Gly Pro Phe Val Gly
                 405                 410                 415    
 Pro Cys Gly His Trp Ile Arg Pro Ser Glu Thr Leu Gln Lys Tyr Leu
             420                 425                 430        
 Lys Val Val Met Ala Leu Thr Tyr Glu Glu Lys Pro Pro Tyr Ala Met
         435                 440                 445            
 Leu Arg Asn Asn Leu Glu Ala Leu Leu Gln Asp Leu Arg Val Ser Pro
     450                 455                 460                
 Tyr Asp Pro Ile Gly Leu Pro Met Val Pro
 465                 470                



      <210> 191
      <211> 369
      <212> PRT
      <213> Homo sapiens


      <400> 191
 Met Cys Ser Leu Pro Arg Gly Phe Glu Pro Gln Ala Pro Glu Asp Leu
   1               5                  10                  15    
 Ala Gln Arg Ser Leu Val Glu Leu Arg Glu Met Leu Lys Arg Gln Glu
              20                  25                  30        
 Arg Leu Leu Arg Asn Glu Lys Phe Ile Cys Lys Leu Pro Asp Lys Gly
          35                  40                  45            
 Lys Lys Ile Phe Asp Ser Phe Ala Lys Leu Lys Ala Ala Ile Ala Glu
      50                  55                  60                
 Cys Glu Glu Val Arg Arg Lys Ser Glu Leu Phe Asn Pro Val Ser Leu
  65                  70                  75                  80
 Asp Cys Lys Leu Arg Gln Lys Ala Ile Ala Glu Val Asp Val Gly Thr
                  85                  90                  95    
 Asp Lys Ala Gln Asn Ser Asp Pro Ile Leu Asp Thr Ser Ser Leu Val
             100                 105                 110        
 Pro Gly Cys Ser Ser Val Asp Asn Ile Lys Ser Ser Gln Thr Ser Gln
         115                 120                 125            
 Asn Gln Gly Leu Gly Arg Pro Thr Leu Glu Gly Asp Glu Glu Thr Ser
     130                 135                 140                
 Glu Val Glu Tyr Thr Val Asn Lys Gly Pro Ala Ser Ser Asn Arg Asp
 145                 150                 155                 160
 Arg Val Pro Pro Ser Ser Glu Ala Ser Glu His His Pro Arg His Arg
                 165                 170                 175    
 Val Ser Ser Gln Ala Glu Asp Thr Ser Ser Ser Phe Asp Asn Leu Phe
             180                 185                 190        
 Ile Asp Arg Leu Gln Arg Ile Thr Ile Ala Asp Gln Gly Glu Gln Gln
         195                 200                 205            
 Ser Glu Glu Asn Ala Ser Thr Lys Asn Leu Thr Gly Leu Ser Ser Gly
     210                 215                 220                
 Thr Glu Lys Lys Pro His Tyr Met Glu Val Leu Glu Met Arg Ala Lys
 225                 230                 235                 240
 Asn Pro Val Pro Gln Leu Arg Lys Phe Lys Thr Asn Val Leu Pro Phe
                 245                 250                 255    
 Arg Gln Asn Asp Ser Ser Ser His Cys Gln Lys Ser Gly Ser Pro Ile
             260                 265                 270        
 Ser Ser Glu Glu Arg Arg Arg Arg Asp Lys Gln His Leu Asp Asp Ile
         275                 280                 285            
 Thr Ala Ala Arg Leu Leu Pro Leu His His Met Pro Thr Gln Leu Leu
     290                 295                 300                
 Ser Ile Glu Glu Ser Leu Ala Leu Gln Lys Gln Gln Lys Gln Asn Tyr
 305                 310                 315                 320
 Glu Glu Met Gln Ala Lys Leu Ala Ala Gln Lys Leu Ala Glu Arg Leu
                 325                 330                 335    
 Asn Ile Lys Met Arg Ser Tyr Asn Pro Glu Gly Glu Ser Ser Gly Arg
             340                 345                 350        
 Tyr Arg Glu Val Arg Asp Glu Asp Asp Asp Trp Ser Ser Asp Glu Phe
         355                 360                 365            





      <210> 192
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 192
 Met Ser His Arg Ile Phe Phe Phe Cys Tyr Leu Lys Ala Lys Ile Lys
   1               5                  10                  15    
 Ile Leu Gly Trp Ala Arg Trp Leu Val Pro Val Ile Pro Ala Leu Trp
              20                  25                  30        
 Glu Ala Glu Val Gly Arg Ser Phe Glu Ala Arg Ser Ser Arg Thr Ala
          35                  40                  45            
 Trp Ala Thr
      50    



      <210> 193
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 193
 Met Ala Cys Asn Ile Pro Asn Gln Arg Gln Arg Thr Leu Ser Thr Thr
   1               5                  10                  15    
 Gly Glu Ala Leu Tyr Glu Ile Leu Gly Leu His Lys Gly Ala Ser Asn
              20                  25                  30        
 Glu Glu Ile Lys Lys Thr Tyr Arg Lys Leu Ala Leu Lys His His Pro
          35                  40                  45            
 Asp Lys Asn Pro Asp Asp Pro Ala Ala Thr Glu Lys Phe Lys Glu Ile
      50                  55                  60                
 Asn Asn Ala His Ala Ile Leu Thr Asp Ile Ser Lys Arg Ser Ile Tyr
  65                  70                  75                  80
 Asp Lys Tyr Gly Ser Leu Gly Leu Tyr Val Ala Glu Gln Phe Gly Asp
                  85                  90                  95    
 Glu Asn Val Asn Thr Tyr Phe Met Leu Ser Ser Trp Trp Ala Lys Ala
             100                 105                 110        
 Leu Phe Val Ile Val Gly Leu Leu Thr Gly Cys Tyr Phe Cys Cys Cys
         115                 120                 125            
 Leu Cys Cys Cys Cys Asn Cys Cys Cys Gly His Cys Arg Pro Glu Ser
     130                 135                 140                
 Ser Val Pro Glu Glu Asp Phe Tyr Val Ser Pro Glu Asp Leu Glu Glu
 145                 150                 155                 160
 Gln Ile Lys Ser Asp Met Glu Lys Asp Val Asp Phe Pro Val Phe Leu
                 165                 170                 175    
 Gln Pro Thr Asn Ala Asn Glu Lys Thr Gln Leu Ile Lys Glu Gly Ser
             180                 185                 190        
 Arg Ser Tyr Cys Thr Asp Ser
         195                



      <210> 194
      <211> 472
      <212> PRT
      <213> Homo sapiens


      <400> 194
 Met Arg Gly Ser Pro Gly Asp Ala Glu Arg Arg Gln Arg Trp Gly Arg
   1               5                  10                  15    
 Leu Phe Glu Glu Leu Asp Ser Asn Lys Asp Gly Arg Val Asp Val His
              20                  25                  30        
 Glu Leu Arg Gln Gly Leu Ala Arg Leu Gly Gly Gly Asn Pro Asp Pro
          35                  40                  45            
 Gly Ala Gln Gln Gly Ile Ser Ser Glu Gly Asp Ala Asp Pro Asp Gly
      50                  55                  60                
 Gly Leu Asp Leu Glu Glu Phe Ser Arg Tyr Leu Gln Glu Arg Glu Gln
  65                  70                  75                  80
 Arg Leu Leu Leu Met Phe His Ser Leu Asp Arg Asn Gln Asp Gly His
                  85                  90                  95    
 Ile Asp Val Ser Glu Ile Gln Gln Ser Phe Arg Ala Leu Gly Ile Ser
             100                 105                 110        
 Ile Ser Leu Glu Gln Ala Glu Lys Ile Leu His Ser Met Asp Arg Asp
         115                 120                 125            
 Gly Thr Met Thr Ile Asp Trp Gln Glu Trp Arg Asp His Phe Leu Leu
     130                 135                 140                
 His Ser Leu Glu Asn Val Glu Asp Val Leu Tyr Phe Trp Lys His Ser
 145                 150                 155                 160
 Thr Val Leu Asp Ile Gly Glu Cys Leu Thr Val Pro Asp Glu Phe Ser
                 165                 170                 175    
 Lys Gln Glu Lys Leu Thr Gly Met Trp Trp Lys Gln Leu Val Ala Gly
             180                 185                 190        
 Ala Val Ala Gly Ala Val Ser Arg Thr Gly Thr Ala Pro Leu Asp Arg
         195                 200                 205            
 Leu Lys Val Phe Met Gln Val His Ala Ser Lys Thr Asn Arg Leu Asn
     210                 215                 220                
 Ile Leu Gly Gly Leu Arg Ser Met Val Leu Glu Gly Gly Ile Arg Ser
 225                 230                 235                 240
 Leu Trp Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala Pro Glu Ser
                 245                 250                 255    
 Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Ala Ile Leu Gly
             260                 265                 270        
 Gln Gln Glu Thr Leu His Val Gln Glu Arg Phe Val Ala Gly Ser Leu
         275                 280                 285            
 Ala Gly Ala Thr Ala Gln Thr Ile Ile Tyr Pro Met Glu Val Leu Lys
     290                 295                 300                
 Thr Arg Leu Thr Leu Arg Arg Thr Gly Gln Tyr Lys Gly Leu Leu Asp
 305                 310                 315                 320
 Cys Ala Arg Arg Ile Leu Glu Arg Glu Gly Pro Arg Ala Phe Tyr Arg
                 325                 330                 335    
 Gly Tyr Leu Pro Asn Val Leu Gly Ile Ile Pro Tyr Ala Gly Ile Asp
             340                 345                 350        
 Leu Ala Val Tyr Glu Thr Leu Lys Asn Trp Trp Leu Gln Gln Tyr Ser
         355                 360                 365            
 His Asp Ser Ala Asp Pro Gly Ile Leu Val Leu Leu Ala Cys Gly Thr
     370                 375                 380                
 Ile Ser Ser Thr Cys Gly Gln Ile Ala Ser Tyr Pro Leu Ala Leu Val
 385                 390                 395                 400
 Arg Thr Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Gly Pro Gln Leu
                 405                 410                 415    
 Ser Met Leu Gly Leu Leu Arg His Ile Leu Ser Gln Glu Gly Met Arg
             420                 425                 430        
 Gly Leu Tyr Arg Gly Ile Ala Pro Asn Phe Met Lys Val Ile Pro Ala
         435                 440                 445            
 Val Ser Ile Ser Tyr Val Val Tyr Glu Asn Met Lys Gln Ala Leu Gly
     450                 455                 460                
 Val Thr Ser Arg Ser Phe Cys
 465                 470    



      <210> 195
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 195
 Met Cys Phe Ser Leu Val Phe Ala Cys Leu Ser Val Arg Leu Ser Val
   1               5                  10                  15    
 Trp Gly Leu Asp Leu Arg Ser Arg Ala Pro Leu Leu Pro Gln Pro Pro
              20                  25                  30        
 Pro Pro Cys Pro Thr Leu Gly Thr Glu Leu Glu Gln Val Trp Pro Pro
          35                  40                  45            
 Asn His Arg Trp Glu Pro Ala Gly Ser Ala Trp Ala Thr Ala Ser Thr
      50                  55                  60                
 Leu Ala Pro Glu Ser Cys Val Cys Lys Cys Val Cys Val Tyr Ala Cys
  65                  70                  75                  80
 Leu Ser Met Cys Met Tyr Val His Gly Glu Pro Val Cys Lys Tyr Val
                  85                  90                  95    
 Gln Arg Glu Thr Val Thr Val Thr Glu Ala Gly Gly Arg Trp Gly Cys
             100                 105                 110        
 Trp Arg Arg Gly Leu Pro Gly Ala Asp Ser Ser Gln Val Asp Pro Pro
         115                 120                 125            
 Gln Val Ser Gly Arg Cys Asp Arg Val Ala Leu Arg Ala Glu Leu Leu
     130                 135                 140                
 Gly Thr Gln Gly Pro Gln Pro Ala Leu Leu Ala Val His Val Pro Thr
 145                 150                 155                 160
 Leu Asp Gly Arg
                



      <210> 196
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 196
 Met Lys Leu Asn Glu Arg Ser Val Ala His Tyr Ala Leu Ser Asp Ser
   1               5                  10                  15    
 Pro Ala Asp His Met Gly Phe Leu Arg Thr Trp Gly Gly Pro Gly Thr
              20                  25                  30        
 Pro Pro Thr Pro Ser Gly Thr Gly Arg Arg Cys Trp Phe Val Leu Lys
          35                  40                  45            
 Gly Asn Leu Leu Phe Ser Phe Glu Ser Arg Glu Gly Arg Ala Pro Leu
      50                  55                  60                
 Ser Leu Val Val Leu Glu Gly Cys Thr Val Glu Leu Ala Glu Ala Pro
  65                  70                  75                  80
 Val Pro Glu Glu Phe Ala Phe Ala Ile Cys Phe Asp Ala Pro Gly Val
                  85                  90                  95    
 Arg Pro His Leu Leu Ala Ala Glu Gly Pro Ala Ala Gln Glu Ala Trp
             100                 105                 110        
 Val Lys Val Leu Ser Arg Ala Ser Phe Gly Tyr Met Arg Leu Val Val
         115                 120                 125            
 Arg Glu Leu Glu Ser Gln Leu Gln Asp Ala Arg Gln Ser Leu Ala Leu
     130                 135                 140                
 Gln Arg Arg Ser Ser Trp Lys Phe Val Ala Ser Arg Cys Lys Pro Gln
 145                 150                 155                 160
 Ala Pro Asn His Arg Ala Ala Gly Leu Glu Asn Gly His Cys Leu Ser
                 165                 170                 175    
 Lys Asp Ser Ser Pro Val Gly Leu Val Glu Glu Gly Gly Ser Arg Ser
             180                 185                 190        
 Ala Gly Trp Gly Leu Ala Glu Trp Glu Leu Gln Gly Pro Ala Ser Leu
         195                 200                 205            
 Leu Leu Gly Lys Gly Gln Ser Pro Val Ser Pro Glu Thr Ser Cys Phe
     210                 215                 220                
 Ser Thr Leu His Asp Trp Tyr Gly Gln Glu Ile Val Glu Leu Arg Gln
 225                 230                 235                 240
 Cys Trp Gln Lys Arg Ala Gln Gly Ser His Ser Lys Cys Glu Glu Gln
                 245                 250                 255    
 Asp Arg Pro
            



      <210> 197
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 197
 Met Asn Glu Asn Leu Phe Ala Ser Phe Ile Ala Pro Thr Ile Leu Gly
   1               5                  10                  15    
 Leu Pro Ala Ala Val Leu Ile Ile Leu Phe Pro Pro Leu Leu Ile Pro
              20                  25                  30        
 Thr Ser Lys Tyr Leu Ile Asn Asn Arg Leu Ile Thr Thr Gln Gln
          35                  40                  45        



      <210> 198
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 198
 Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys
   1               5                  10                  15    
 Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys
              20                  25                  30        
 Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val
          35                  40                  45            
 Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe
      50                  55                  60                
 His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys
  65                  70                  75                  80
 Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys
                  85                  90                  95    
 Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys
             100                 105                 110        
 Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys
         115                 120                 125            
 Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu
     130                 135                 140



      <210> 199
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 199
 Met Ala Ala Ala Asn Lys Gly Asn Lys Pro Arg Val Arg Ser Ile Arg
   1               5                  10                  15    
 Phe Ala Ala Gly His Asp Ala Glu Gly Ser His Ser His Val His Phe
              20                  25                  30        
 Asp Glu Lys Leu His Asp Ser Val Val Met Val Thr Gln Glu Ser Asp
          35                  40                  45            
 Ser Ser Phe Leu Val Lys Val Gly Phe Leu Lys Ile Leu His Arg Tyr
      50                  55                  60                
 Glu Ile Thr Phe Thr Leu Pro Pro Val His Arg Leu Ser Lys Asp Val
  65                  70                  75                  80
 Arg Glu Ala Pro Val Pro Ser Leu His Leu Lys Leu Leu Ser Val Val
                  85                  90                  95    
 Pro Val Pro Glu Gly Tyr Ser Val Lys Cys Glu Tyr Ser Ala His Lys
             100                 105                 110        
 Glu Gly Val Leu Lys Glu Glu Ile Leu Leu Ala Cys Glu Gly Gly Thr
         115                 120                 125            
 Gly Thr Cys Val Arg Val Thr Val Gln Ala Arg Val Met Asp Arg His
     130                 135                 140                
 His Gly Thr Pro Met Leu Leu Asp Gly Val Lys Cys Val Gly Ala Glu
 145                 150                 155                 160
 Leu Glu Tyr Asp Ser Glu His Ser Asp Trp His Gly Phe Asp
                 165                 170                



      <210> 200
      <211> 237
      <212> PRT
      <213> Homo sapiens


      <400> 200
 Met Met Glu Lys Lys Lys Pro Cys Lys Tyr Ser Glu Cys Gly Arg Thr
   1               5                  10                  15    
 Phe Arg Gly His Ile Thr Leu Val Gln His Gln Ile Thr His Cys Gly
              20                  25                  30        
 Glu Arg Pro Cys Lys Cys Thr Glu Cys Arg Lys Gly Phe Asn Gln Ser
          35                  40                  45            
 Ser His Leu Arg Asn Asn Gln Arg Lys Thr Leu Ser Gly Glu Lys Pro
      50                  55                  60                
 Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ser Tyr Cys Leu Val Leu
  65                  70                  75                  80
 Asn Gln His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Glu Gly Thr
                  85                  90                  95    
 Glu Cys Gly Lys Thr Phe Ile Gln Ser Tyr Ile Pro Tyr Ser Ala Ser
             100                 105                 110        
 Lys Asn Ser His Thr Gly Glu Lys Pro Tyr Thr Cys Leu Glu Cys Gly
         115                 120                 125            
 Arg Leu Phe Ser Gln Asn Thr His Leu Thr Leu His Gln Arg Ile His
     130                 135                 140                
 Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Arg Ser Phe Ser
 145                 150                 155                 160
 Gln Thr Ala His Leu Thr Gln His Gln Arg Met Tyr Thr Gly Glu Lys
                 165                 170                 175    
 Leu Tyr Glu Cys Asn Glu Cys Glu Lys Ala Phe His Asp His Ser Ala
             180                 185                 190        
 Leu Ile Gln His His Ile Val His Thr Ala Glu Lys Pro Tyr Glu Tyr
         195                 200                 205            
 His Asp Trp Glu Asn Phe Gln Leu Leu Phe Arg Pro His Ser Thr Ser
     210                 215                 220                
 Glu Asn Ala His Trp Arg Glu Thr Ile Gln Met Gln
 225                 230                 235    



      <210> 201
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 201
 Met Leu Leu Glu Leu Ser Glu Glu His Lys Glu His Leu Ala Phe Leu
   1               5                  10                  15    
 Pro Gln Val Asp Ser Ala Val Val Ala Glu Phe Gly Arg Ile Ala Val
              20                  25                  30        
 Glu Phe Leu Arg Arg Gly Ala Asn Pro Lys Ile Tyr Glu Gly Ala Ala
          35                  40                  45            
 Arg Lys Leu Asn Val Ser Ser Asp Thr Val Gln His Gly Val Glu Gly
      50                  55                  60                
 Leu Thr Tyr Leu Leu Thr Glu Ser Ser Lys Leu Met Ile Ser Glu Leu
  65                  70                  75                  80
 Asp Phe Gln Asp Ser Val Phe Val Leu Gly Phe Ser Glu Glu Leu Asn
                  85                  90                  95    
 Lys Leu Leu Leu Gln Leu Tyr Leu Asp Asn Arg Lys Glu Ile Arg Thr
             100                 105                 110        
 Leu Leu Ser Glu Leu Ala Pro Ser Leu Pro Ser Tyr His Asn Leu Glu
         115                 120                 125            
 Trp Arg Leu Asp Val Gln Leu Ala Ser Arg Ser Leu Arg Gln Gln Ile
     130                 135                 140                
 Lys Pro Ala Val Thr Ile Lys Leu His Leu Asn Gln Asn Gly Asp His
 145                 150                 155                 160
 Asn Thr Lys Val Leu Gln Thr Asp Pro Ala Thr Leu Leu His Leu Val
                 165                 170                 175    
 Gln Gln Leu Glu Gln Ala Leu Glu Glu Met Lys Thr Asn His Cys Arg
             180                 185                 190        
 Arg Val Val Arg Asn Ile Lys
         195                



      <210> 202
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 202
 Met Lys Leu Ile Val Gly Ile Gly Gly Met Thr Asn Gly Gly Lys Thr
   1               5                  10                  15    
 Thr Leu Thr Asn Ser Leu Leu Arg Ala Leu Pro Asn Cys Cys Val Ile
              20                  25                  30        
 His Gln Asp Asp Phe Phe Lys Pro Gln Asp Gln Ile Ala Val Gly Glu
          35                  40                  45            
 Asp Gly Phe Lys Gln Trp Asp Val Leu Glu Ser Leu Asp Met Glu Ala
      50                  55                  60                
 Met Leu Asp Thr Val Gln Ala Trp Leu Ser Ser Pro Gln Lys Phe Ala
  65                  70                  75                  80
 Arg Ala His Gly Val Ser Val Gln Pro Glu Ala Ser Asp Thr His Ile
                  85                  90                  95    
 Leu Leu Leu Glu Gly Phe Leu Leu Tyr Ser Tyr Lys Pro Leu Val Asp
             100                 105                 110        
 Leu Tyr Ser Arg Arg Tyr Phe Leu Thr Val Pro Tyr Glu Glu Cys Lys
         115                 120                 125            
 Trp Arg Arg Ser Thr Arg Asn Tyr Thr Val Pro Asp Pro Pro Gly Leu
     130                 135                 140                
 Phe Asp Gly His Val Trp Pro Met Tyr Gln Lys Tyr Arg Gln Glu Met
 145                 150                 155                 160
 Glu Ala Asn Gly Val Glu Val Val Tyr Leu Asp Gly Met Lys Ser Arg
                 165                 170                 175    
 Glu Glu Leu Phe Arg Glu Val Leu Glu Asp Ile Gln Asn Ser Leu Leu
             180                 185                 190        
 Asn Arg Ser Gln Glu Ser Ala Pro Ser Pro Ala Arg Pro Ala Arg Thr
         195                 200                 205            
 Gln Gly Pro Gly Arg Gly Cys Gly His Arg Thr Ala Arg Pro Ala Ala
     210                 215                 220                
 Ser Gln Gln Asp Ser Met
 225                 230



      <210> 203
      <211> 416
      <212> PRT
      <213> Homo sapiens


      <400> 203
 Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu
   1               5                  10                  15    
 Ala Gln Pro Glu Ser Pro Thr Ala Ser Ala Gly Asp Glu Pro Arg Ser
              20                  25                  30        
 Thr Pro Glu Ser Gly Asp Ser Asp Lys Glu Ser Val Gly Ser Ser Ser
          35                  40                  45            
 Thr Ser Asn Glu Gly Gly Arg Arg Lys Glu Lys Ser Lys Arg Asp Arg
      50                  55                  60                
 Glu Lys Asp Lys Lys Arg Ala Asp Ser Val Ala Asn Lys Leu Gly Ser
  65                  70                  75                  80
 Phe Gly Lys Thr Leu Gly Ser Lys Leu Lys Lys Asn Met Gly Gly Leu
                  85                  90                  95    
 Met His Ser Lys Gly Ser Lys Pro Gly Gly Val Gly Thr Gly Leu Gly
             100                 105                 110        
 Gly Ser Ser Gly Thr Glu Thr Leu Glu Lys Lys Lys Lys Asn Ser Leu
         115                 120                 125            
 Lys Ser Trp Lys Gly Gly Lys Glu Glu Ala Ala Gly Asp Gly Pro Val
     130                 135                 140                
 Ser Glu Lys Pro Pro Ala Glu Ser Val Gly Asn Gly Gly Ser Lys Tyr
 145                 150                 155                 160
 Ser Gln Glu Val Met Gln Ser Leu Ser Ile Leu Arg Thr Ala Met Gln
                 165                 170                 175    
 Gly Glu Gly Lys Phe Ile Phe Val Gly Thr Leu Lys Met Gly His Arg
             180                 185                 190        
 His Gln Tyr Gln Glu Glu Met Ile Gln Arg Tyr Leu Ser Asp Ala Glu
         195                 200                 205            
 Glu Arg Phe Leu Ala Glu Gln Lys Gln Lys Glu Ala Glu Arg Lys Ile
     210                 215                 220                
 Met Asn Gly Gly Ile Gly Gly Gly Pro Pro Pro Ala Lys Lys Pro Glu
 225                 230                 235                 240
 Pro Asp Ala Arg Glu Glu Gln Pro Thr Gly Pro Pro Ala Glu Ser Arg
                 245                 250                 255    
 Ala Met Ala Phe Ser Thr Gly Tyr Pro Gly Asp Phe Thr Ile Pro Arg
             260                 265                 270        
 Pro Ser Gly Gly Gly Val His Cys Gln Glu Pro Arg Arg Gln Leu Ala
         275                 280                 285            
 Gly Gly Pro Cys Val Gly Gly Leu Pro Pro Tyr Ala Thr Phe Pro Arg
     290                 295                 300                
 Gln Cys Pro Pro Gly Arg Pro Tyr Pro His Gln Asp Ser Ile Pro Ser
 305                 310                 315                 320
 Leu Glu Pro Gly Ser His Ser Lys Asp Gly Leu His Arg Gly Ala Leu
                 325                 330                 335    
 Leu Pro Pro Pro Tyr Arg Val Ala Asp Ser Tyr Ser Asn Gly Tyr Arg
             340                 345                 350        
 Glu Pro Pro Glu Pro Asp Gly Trp Ala Gly Gly Leu Arg Gly Leu Pro
         355                 360                 365            
 Pro Thr Gln Thr Lys Cys Lys Gln Pro Asn Cys Ser Phe Tyr Gly His
     370                 375                 380                
 Pro Glu Thr Asn Asn Phe Cys Ser Cys Cys Tyr Arg Glu Glu Leu Arg
 385                 390                 395                 400
 Arg Arg Glu Arg Glu Pro Asp Gly Glu Leu Leu Val His Arg Phe
                 405                 410                 415



      <210> 204
      <211> 565
      <212> PRT
      <213> Homo sapiens


      <400> 204
 Met Leu Ala Asn Ser Ala Ser Val Arg Ile Leu Ile Lys Gly Gly Lys
   1               5                  10                  15    
 Val Val Asn Asp Asp Cys Thr His Glu Ala Asp Val Tyr Ile Glu Asn
              20                  25                  30        
 Gly Ile Ile Gln Gln Val Gly Arg Glu Leu Met Ile Pro Gly Gly Ala
          35                  40                  45            
 Lys Val Ile Asp Ala Thr Gly Lys Leu Val Ile Pro Gly Gly Ile Asp
      50                  55                  60                
 Thr Ser Thr His Phe His Gln Thr Phe Met Asn Ala Thr Cys Val Asp
  65                  70                  75                  80
 Asp Phe Tyr His Gly Thr Lys Ala Ala Leu Val Gly Gly Thr Thr Met
                  85                  90                  95    
 Ile Ile Gly His Val Leu Pro Asp Lys Glu Thr Ser Leu Val Asp Ala
             100                 105                 110        
 Tyr Glu Lys Cys Arg Gly Leu Ala Asp Pro Lys Val Cys Cys Asp Tyr
         115                 120                 125            
 Ala Leu His Val Gly Ile Thr Trp Trp Ala Pro Lys Val Lys Ala Glu
     130                 135                 140                
 Met Glu Thr Leu Val Arg Glu Lys Gly Val Asn Ser Phe Gln Met Phe
 145                 150                 155                 160
 Met Thr Tyr Lys Asp Leu Tyr Met Leu Arg Asp Ser Glu Leu Tyr Gln
                 165                 170                 175    
 Val Leu His Ala Cys Lys Asp Ile Gly Ala Ile Ala Arg Val His Ala
             180                 185                 190        
 Glu Asn Gly Glu Leu Val Ala Glu Gly Ala Lys Glu Ala Leu Asp Leu
         195                 200                 205            
 Gly Ile Thr Gly Pro Glu Gly Ile Glu Ile Ser Arg Pro Glu Glu Leu
     210                 215                 220                
 Glu Ala Glu Ala Thr His Arg Val Ile Thr Ile Ala Asn Arg Thr His
 225                 230                 235                 240
 Cys Pro Ile Tyr Leu Val Asn Val Ser Ser Ile Ser Ala Gly Asp Val
                 245                 250                 255    
 Ile Ala Ala Ala Lys Met Gln Gly Lys Val Val Leu Ala Glu Thr Thr
             260                 265                 270        
 Thr Ala His Ala Thr Leu Thr Gly Leu His Tyr Tyr His Gln Asp Trp
         275                 280                 285            
 Ser His Ala Ala Ala Tyr Val Thr Val Pro Pro Leu Arg Leu Asp Thr
     290                 295                 300                
 Asn Thr Ser Thr Tyr Leu Met Ser Leu Leu Ala Asn Asp Thr Leu Asn
 305                 310                 315                 320
 Ile Val Ala Ser Asp His Arg Pro Phe Thr Thr Lys Gln Lys Ala Met
                 325                 330                 335    
 Gly Lys Glu Asp Phe Thr Lys Ile Pro His Gly Val Ser Gly Val Gln
             340                 345                 350        
 Asp Arg Met Ser Val Ile Trp Glu Arg Gly Val Val Gly Gly Lys Met
         355                 360                 365            
 Asp Glu Asn Arg Phe Val Ala Val Thr Ser Ser Asn Ala Ala Lys Leu
     370                 375                 380                
 Leu Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ile Pro Gly Ala Asp Ala
 385                 390                 395                 400
 Asp Val Val Val Trp Asp Pro Glu Ala Thr Lys Thr Ile Ser Ala Ser
                 405                 410                 415    
 Thr Gln Val Gln Gly Gly Asp Phe Asn Leu Tyr Glu Asn Met Arg Cys
             420                 425                 430        
 His Gly Val Pro Leu Val Thr Ile Ser Arg Gly Arg Val Val Tyr Glu
         435                 440                 445            
 Asn Gly Val Phe Met Cys Ala Glu Gly Thr Gly Lys Phe Cys Pro Leu
     450                 455                 460                
 Arg Ser Phe Pro Asp Thr Val Tyr Lys Lys Leu Val Gln Arg Glu Lys
 465                 470                 475                 480
 Thr Leu Lys Val Arg Gly Val Asp Arg Thr Pro Tyr Leu Gly Asp Val
                 485                 490                 495    
 Ala Val Val Val His Pro Gly Lys Lys Glu Met Gly Thr Pro Leu Ala
             500                 505                 510        
 Asp Thr Pro Thr Arg Pro Val Thr Arg His Gly Gly Met Arg Asp Leu
         515                 520                 525            
 His Glu Ser Ser Phe Ser Leu Ser Gly Ser Gln Ile Asp Asp His Val
     530                 535                 540                
 Pro Lys Arg Ala Ser Ala Arg Ile Leu Ala Pro Pro Gly Gly Arg Ser
 545                 550                 555                 560
 Ser Gly Ile Trp
                



      <210> 205
      <211> 389
      <212> PRT
      <213> Homo sapiens


      <400> 205
 Met Lys Trp Leu Leu Leu Leu Gly Leu Val Ala Leu Ser Glu Cys Ile
   1               5                  10                  15    
 Met Tyr Lys Val Pro Leu Ile Arg Lys Lys Ser Leu Arg Arg Thr Leu
              20                  25                  30        
 Ser Glu Arg Gly Leu Leu Lys Asp Phe Leu Lys Lys His Asn Leu Asn
          35                  40                  45            
 Pro Ala Arg Lys Tyr Phe Pro Gln Trp Glu Ala Pro Thr Leu Val Asp
      50                  55                  60                
 Glu Gln Pro Leu Glu Asn Tyr Leu Asp Met Glu Tyr Phe Gly Thr Ile
  65                  70                  75                  80
 Gly Ile Gly Thr Pro Ala Gln Asp Phe Thr Val Val Phe Asp Thr Gly
                  85                  90                  95    
 Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Ser Ser Leu Ala Cys
             100                 105                 110        
 Thr Asn His Asn Arg Phe Asn Pro Glu Asp Ser Ser Thr Tyr Gln Ser
         115                 120                 125            
 Thr Ser Glu Thr Val Ser Ile Thr Tyr Gly Thr Gly Ser Met Thr Gly
     130                 135                 140                
 Ile Leu Gly Tyr Asp Thr Val Gln Val Gly Gly Ile Ser Asp Thr Asn
 145                 150                 155                 160
 Gln Ile Phe Gly Leu Ser Glu Thr Glu Pro Gly Ser Phe Leu Tyr Tyr
                 165                 170                 175    
 Ala Pro Phe Asp Gly Ile Leu Gly Leu Ala Tyr Pro Ser Ile Ser Ser
             180                 185                 190        
 Ser Gly Ala Thr Pro Val Phe Asp Asn Ile Trp Asn Gln Gly Leu Val
         195                 200                 205            
 Ser Gln Asp Leu Phe Ser Val Tyr Leu Ser Ala Asp Asp Gln Ser Gly
     210                 215                 220                
 Ser Val Val Ile Phe Gly Gly Ile Asp Ser Ser Tyr Tyr Thr Gly Ser
 225                 230                 235                 240
 Leu Asn Trp Val Pro Val Thr Val Glu Gly Tyr Trp Gln Ile Thr Val
                 245                 250                 255    
 Asp Ser Ile Thr Met Asn Gly Glu Ala Ile Ala Cys Ala Glu Gly Cys
             260                 265                 270        
 Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser
         275                 280                 285            
 Pro Ile Ala Asn Ile Gln Ser Asp Ile Gly Ala Ser Glu Asn Ser Asp
     290                 295                 300                
 Gly Asp Met Val Val Ser Cys Ser Ala Ile Ser Ser Leu Pro Asp Ile
 305                 310                 315                 320
 Val Phe Thr Ile Asn Gly Val Gln Tyr Pro Val Pro Pro Ser Ala Tyr
                 325                 330                 335    
 Ile Leu Gln Ser Glu Gly Ser Cys Ile Ser Gly Phe Gln Gly Met Asn
             340                 345                 350        
 Leu Pro Thr Glu Ser Gly Glu Leu Trp Ile Leu Gly Asp Val Phe Ile
         355                 360                 365            
 Arg Gln Tyr Phe Thr Val Phe Asp Arg Ala Asn Asn Gln Val Gly Leu
     370                 375                 380                
 Ala Pro Val Ala
 385            



      <210> 206
      <211> 822
      <212> PRT
      <213> Homo sapiens


      <400> 206
 Met Gly Leu Gly Asn Ala Ser Thr Gly Tyr Gly Lys Ile Trp Leu Asp
   1               5                  10                  15    
 Asp Val Ser Cys Asp Gly Asp Glu Ser Asp Leu Trp Ser Cys Arg Asn
              20                  25                  30        
 Ser Gly Trp Gly Asn Asn Asp Cys Ser His Ser Glu Asp Val Gly Val
          35                  40                  45            
 Ile Cys Ser Asp Ala Ser Asp Met Glu Leu Arg Leu Val Gly Gly Ser
      50                  55                  60                
 Ser Arg Cys Ala Gly Lys Val Glu Val Asn Val Gln Gly Ala Val Gly
  65                  70                  75                  80
 Ile Leu Cys Ala Asn Gly Trp Gly Met Asn Ile Ala Glu Val Val Cys
                  85                  90                  95    
 Arg Gln Leu Glu Cys Gly Ser Ala Ile Arg Val Ser Arg Glu Pro His
             100                 105                 110        
 Phe Thr Glu Arg Thr Leu His Ile Leu Met Ser Asn Ser Gly Cys Thr
         115                 120                 125            
 Gly Gly Glu Ala Ser Leu Trp Asp Cys Ile Arg Trp Glu Trp Lys Gln
     130                 135                 140                
 Thr Ala Cys His Leu Asn Met Glu Ala Ser Leu Ile Cys Ser Ala His
 145                 150                 155                 160
 Arg Gln Pro Arg Leu Val Gly Ala Asp Met Pro Cys Ser Gly Arg Val
                 165                 170                 175    
 Glu Val Lys His Ala Asp Thr Trp Arg Ser Val Cys Asp Ser Asp Phe
             180                 185                 190        
 Ser Leu His Ala Ala Asn Val Leu Cys Arg Glu Leu Asn Cys Gly Asp
         195                 200                 205            
 Ala Ile Ser Leu Ser Val Gly Asp His Phe Gly Lys Gly Asn Gly Leu
     210                 215                 220                
 Thr Trp Ala Glu Lys Phe Gln Cys Glu Gly Ser Glu Thr His Leu Ala
 225                 230                 235                 240
 Leu Cys Pro Ile Val Gln His Pro Glu Asp Thr Cys Ile His Ser Arg
                 245                 250                 255    
 Glu Val Gly Val Val Cys Ser Arg Tyr Thr Asp Val Arg Leu Val Asn
             260                 265                 270        
 Gly Lys Ser Gln Cys Asp Gly Gln Val Glu Ile Asn Val Leu Gly His
         275                 280                 285            
 Trp Gly Ser Leu Cys Asp Thr His Trp Asp Pro Glu Asp Ala Arg Val
     290                 295                 300                
 Leu Cys Arg Gln Leu Ser Cys Gly Thr Ala Leu Ser Thr Thr Gly Gly
 305                 310                 315                 320
 Lys Tyr Ile Gly Glu Arg Ser Val Arg Val Trp Gly His Arg Phe His
                 325                 330                 335    
 Cys Leu Gly Asn Glu Ser Leu Leu Asp Asn Cys Gln Met Thr Val Leu
             340                 345                 350        
 Gly Ala Pro Pro Cys Ile His Gly Asn Thr Val Ser Val Ile Cys Thr
         355                 360                 365            
 Gly Ser Leu Thr Gln Pro Leu Phe Pro Cys Leu Ala Asn Val Ser Asp
     370                 375                 380                
 Pro Tyr Leu Ser Ala Val Pro Glu Gly Ser Ala Leu Ile Cys Leu Glu
 385                 390                 395                 400
 Asp Lys Arg Leu Arg Leu Val Asp Gly Asp Ser Arg Cys Ala Gly Arg
                 405                 410                 415    
 Val Glu Ile Tyr His Asp Gly Phe Trp Gly Thr Ile Cys Asp Asp Gly
             420                 425                 430        
 Trp Asp Leu Ser Asp Ala His Val Val Cys Gln Lys Leu Gly Cys Gly
         435                 440                 445            
 Val Ala Phe Asn Ala Thr Val Ser Ala His Phe Gly Glu Gly Ser Gly
     450                 455                 460                
 Pro Ile Trp Leu Asp Asp Leu Asn Cys Thr Gly Met Glu Ser His Leu
 465                 470                 475                 480
 Trp Gln Cys Pro Ser Arg Gly Trp Gly Gln His Asp Cys Arg His Lys
                 485                 490                 495    
 Glu Asp Ala Gly Val Ile Cys Ser Glu Phe Thr Ala Leu Arg Leu Tyr
             500                 505                 510        
 Ser Glu Thr Glu Thr Glu Ser Cys Ala Gly Arg Leu Glu Val Phe Tyr
         515                 520                 525            
 Asn Gly Thr Trp Gly Ser Val Gly Arg Arg Asn Ile Thr Thr Ala Ile
     530                 535                 540                
 Ala Gly Ile Val Cys Arg Gln Leu Gly Cys Gly Glu Asn Gly Val Val
 545                 550                 555                 560
 Ser Leu Ala Pro Leu Ser Lys Thr Gly Ser Gly Phe Met Trp Val Asp
                 565                 570                 575    
 Asp Ile Gln Cys Pro Lys Thr His Ile Ser Ile Trp Gln Cys Leu Ser
             580                 585                 590        
 Ala Pro Trp Glu Arg Arg Ile Ser Ser Pro Ala Glu Glu Thr Trp Ile
         595                 600                 605            
 Thr Cys Glu Asp Arg Ile Arg Val Arg Gly Gly Asp Thr Glu Cys Ser
     610                 615                 620                
 Gly Arg Val Glu Ile Trp His Ala Gly Ser Trp Gly Thr Val Cys Asp
 625                 630                 635                 640
 Asp Ser Trp Asp Leu Ala Glu Ala Glu Val Val Cys Gln Gln Leu Gly
                 645                 650                 655    
 Cys Gly Ser Ala Leu Ala Ala Leu Arg Asp Ala Ser Phe Gly Gln Gly
             660                 665                 670        
 Thr Gly Thr Ile Trp Leu Asp Asp Met Arg Cys Lys Gly Asn Glu Ser
         675                 680                 685            
 Phe Leu Trp Asp Cys His Ala Lys Pro Trp Gly Gln Ser Asp Cys Gly
     690                 695                 700                
 His Lys Glu Asp Ala Gly Val Arg Cys Ser Gly Gln Ser Leu Lys Ser
 705                 710                 715                 720
 Leu Asn Ala Ser Ser Gly His Leu Ala Leu Ile Leu Ser Ser Ile Phe
                 725                 730                 735    
 Gly Leu Leu Leu Leu Val Leu Phe Ile Leu Phe Leu Thr Trp Cys Arg
             740                 745                 750        
 Val Gln Lys Gln Lys His Leu Pro Leu Arg Val Ser Thr Arg Arg Arg
         755                 760                 765            
 Gly Ser Leu Glu Glu Asn Leu Phe His Glu Met Glu Thr Cys Leu Lys
     770                 775                 780                
 Arg Glu Asp Pro His Gly Thr Arg Thr Ser Asp Asp Thr Pro Asn His
 785                 790                 795                 800
 Gly Cys Glu Asp Ala Ser Asp Thr Ser Leu Leu Gly Val Leu Pro Ala
                 805                 810                 815    
 Ser Glu Ala Thr Lys
             820    



      <210> 207
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 207
 Met Pro Met Lys Gly Arg Phe Pro Ile Arg Arg Thr Leu Gln Tyr Leu
   1               5                  10                  15    
 Ser Gln Gly Asn Val Val Phe Lys Asp Ser Val Lys Val Met Thr Val
              20                  25                  30        
 Asn Tyr Asn Thr His Gly Glu Leu Gly Glu Gly Ala Arg Lys Phe Val
          35                  40                  45            
 Phe Phe Asn Ile Pro Gln Ile Gln Tyr Lys Asn Pro Trp Val Gln Ile
      50                  55                  60                
 Met Met Phe Lys Asn Met Thr Pro Ser Pro Phe Leu Arg Phe Tyr Leu
  65                  70                  75                  80
 Asp Ser Gly Glu Gln Val Leu Val Asp Val Glu Thr Lys Ser Asn Lys
                  85                  90                  95    
 Glu Ile Met Glu His Ile Arg Lys Ile Leu Gly Lys Asn Glu Glu Thr
             100                 105                 110        
 Leu Arg Glu Glu Glu Glu Glu Lys Lys Gln Leu Ser His Pro Ala Asn
         115                 120                 125            
 Phe Gly Pro Arg Lys Tyr Cys Leu Arg Glu Cys Ile Cys Glu Val Glu
     130                 135                 140                
 Gly Gln Val Pro Cys Pro Ser Leu Val Pro Leu Pro Lys Glu Met Arg
 145                 150                 155                 160
 Gly Lys Tyr Lys Ala Ala Leu Lys Ala Asp Ala Gln Asp
                 165                 170            



      <210> 208
      <211> 100
      <212> PRT
      <213> Homo sapiens


      <400> 208
 Met Arg Leu Lys Ala Arg Gly Gly Thr Val Glu Asp Lys Val Glu Ile
   1               5                  10                  15    
 Lys Pro Ser Arg Arg Gly Cys Trp Trp Glu Ser Phe Phe Val Cys Leu
              20                  25                  30        
 Phe Phe Glu Thr Glu Ser Tyr Ser Val Ile Gln Ala Gly Val Gln Trp
          35                  40                  45            
 His Asn Leu Ser Ser Leu Gln Pro Pro Pro Pro Glu Phe Lys Leu Phe
      50                  55                  60                
 Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp Phe Arg Leu Pro Pro Pro
  65                  70                  75                  80
 Cys Pro Ala Asn Phe Cys Ile Phe Ser Arg Asp Arg Val Ser Pro Cys
                  85                  90                  95    
 Trp Pro Gly
            



      <210> 209
      <211> 369
      <212> PRT
      <213> Homo sapiens


      <400> 209
 Met Ala Ala Ala Ala Glu Glu Arg Met Ala Glu Glu Gly Gly Gly Gly
   1               5                  10                  15    
 Gln Gly Asp Gly Gly Ser Ser Leu Ala Ser Gly Ser Thr Gln Arg Gln
              20                  25                  30        
 Pro Pro Pro Pro Ala Pro Gln His Pro Gln Pro Gly Ser Gln Ala Leu
          35                  40                  45            
 Pro Ala Pro Ala Leu Ala Pro Asp Gln Leu Pro Gln Asn Asn Thr Leu
      50                  55                  60                
 Val Ala Leu Pro Ile Val Ala Ile Glu Asn Ile Leu Ser Phe Met Ser
  65                  70                  75                  80
 Tyr Asp Glu Ile Ser Gln Leu Arg Leu Val Cys Lys Arg Met Asp Leu
                  85                  90                  95    
 Val Cys Gln Arg Met Leu Asn Gln Gly Phe Leu Lys Val Glu Arg Tyr
             100                 105                 110        
 His Asn Leu Cys Gln Lys Gln Val Lys Ala Gln Leu Pro Arg Arg Glu
         115                 120                 125            
 Ser Glu Arg Arg Asn His Ser Leu Ala Arg His Ala Asp Ile Leu Ala
     130                 135                 140                
 Ala Val Glu Thr Arg Leu Ser Leu Leu Asn Met Thr Phe Met Lys Tyr
 145                 150                 155                 160
 Val Asp Ser Asn Leu Cys Cys Phe Ile Pro Gly Lys Val Ile Asp Glu
                 165                 170                 175    
 Ile Tyr Arg Val Leu Arg Tyr Val Asn Ser Thr Arg Ala Pro Gln Arg
             180                 185                 190        
 Ala His Glu Val Leu Gln Glu Leu Arg Asp Ile Ser Ser Met Ala Met
         195                 200                 205            
 Glu Tyr Phe Asp Glu Lys Ile Val Pro Ile Leu Lys Arg Lys Leu Pro
     210                 215                 220                
 Gly Ser Asp Val Ser Gly Arg Leu Met Gly Ser Pro Pro Val Pro Gly
 225                 230                 235                 240
 Pro Ser Ala Ala Leu Thr Thr Met Gln Leu Phe Ser Lys Gln Asn Pro
                 245                 250                 255    
 Ser Arg Gln Glu Val Thr Lys Leu Gln Gln Gln Val Lys Thr Asn Gly
             260                 265                 270        
 Ala Gly Val Thr Val Leu Arg Arg Glu Ile Ser Glu Leu Arg Thr Lys
         275                 280                 285            
 Val Gln Glu Gln Gln Lys Gln Leu Gln Asp Gln Asp Gln Lys Leu Leu
     290                 295                 300                
 Glu Gln Thr Gln Ile Ile Gly Glu Gln Asn Ala Arg Leu Ala Glu Leu
 305                 310                 315                 320
 Glu Arg Lys Leu Arg Glu Val Met Glu Ser Ala Val Gly Asn Ser Ser
                 325                 330                 335    
 Gly Ser Gly Gln Asn Glu Glu Ser Pro Arg Lys Arg Lys Lys Ala Thr
             340                 345                 350        
 Glu Ala Ile Asp Ser Leu Arg Lys Ser Lys Arg Leu Arg Asn Arg Lys
         355                 360                 365            





      <210> 210
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 210
 Met Thr Pro Asn Arg Gly Pro Leu Ser Pro Pro Asn Asp Leu Arg Pro
   1               5                  10                  15    
 Ser His Val Ile Ser Leu Pro Leu His Asn Ala Pro His Thr Arg Pro
              20                  25                  30        
 Thr Asn Gln His Thr Asn His Ile Pro Met Met Ala Arg Cys Asn Thr
          35                  40                  45            
 Arg Lys His Ile Pro Arg Pro Pro His Thr Thr Cys Pro Lys Arg Pro
      50                  55                  60                
 Ser Ile Arg Asp Asn Pro Ile Tyr Tyr Leu Arg Ser Phe Phe Leu Arg
  65                  70                  75                  80
 Arg Ile Phe Leu Ser Leu Leu Pro Leu Gln Pro Ser Pro Tyr Pro Pro
                  85                  90                  95    
 Ile Arg Arg Ala Leu Ala Pro Asn Arg His His Pro Ala Lys Ser Pro
             100                 105                 110        
 Arg Ser Pro Thr Pro Lys His Ile Arg Ile Thr Arg Ile Arg Ser Ile
         115                 120                 125            
 Asn His Leu Ser Ser Pro
     130                



      <210> 211
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 211
 Met Ala Asn Leu Leu Leu Leu Ile Val Pro Ile Leu Ile Ala Met Ala
   1               5                  10                  15    
 Phe Leu Met Leu Thr Glu Arg Lys Ile Leu Gly Tyr Ile Gln Leu Arg
              20                  25                  30        
 Lys Gly Pro Asn Val Val Gly Pro Tyr Gly Leu Leu Gln Pro Phe Ala
          35                  40                  45            
 Asp Ala Ile Lys Leu Phe Thr Lys Glu Pro Leu Lys Ala Ala Thr Ser
      50                  55                  60                
 Thr Ile Thr Leu Tyr Ile Thr Ala Pro Thr Leu Ala Leu Thr Ile Ala
  65                  70                  75                  80
 Leu Leu Leu
            



      <210> 212
      <211> 416
      <212> PRT
      <213> Homo sapiens


      <400> 212
 Met Ala Asn Pro Ser Gly Phe Gly Leu Gly Ser Ser Asn Leu Thr Asn
   1               5                  10                  15    
 Ala Ile Ser Ser Thr Val Thr Ser Ser Gln Gly Thr Ala Pro Thr Gly
              20                  25                  30        
 Phe Val Phe Gly Pro Ser Thr Thr Ser Val Ala Pro Ala Thr Thr Ser
          35                  40                  45            
 Gly Gly Phe Ser Phe Thr Gly Gly Ser Thr Ala Gln Pro Ser Gly Phe
      50                  55                  60                
 Asn Ile Gly Ser Ala Gly Asn Ser Ala Gln Pro Thr Ala Pro Ala Thr
  65                  70                  75                  80
 Leu Pro Phe Thr Pro Ala Thr Pro Ala Ala Thr Thr Ala Gly Ala Thr
                  85                  90                  95    
 Gln Pro Ala Ala Pro Thr Pro Thr Ala Thr Ile Thr Ser Thr Gly Pro
             100                 105                 110        
 Ser Leu Phe Ala Ser Ile Ala Thr Ala Pro Thr Ser Ser Ala Thr Thr
         115                 120                 125            
 Gly Leu Ser Leu Cys Thr Pro Val Thr Thr Ala Gly Ala Pro Thr Ala
     130                 135                 140                
 Gly Thr Gln Gly Phe Ser Leu Lys Ala Pro Gly Ala Ala Ser Gly Thr
 145                 150                 155                 160
 Ser Thr Thr Thr Ser Thr Ala Ala Thr Ala Thr Ala Thr Thr Thr Thr
                 165                 170                 175    
 Ser Ser Ser Thr Thr Gly Phe Ala Leu Asn Leu Lys Pro Leu Ala Pro
             180                 185                 190        
 Ala Gly Ile Pro Ser Asn Thr Ala Ala Ala Val Thr Ala Pro Pro Gly
         195                 200                 205            
 Pro Gly Ala Ala Ala Gly Ala Ala Ala Ser Ser Ala Met Thr Tyr Ala
     210                 215                 220                
 Gln Leu Glu Ser Leu Ile Asn Lys Trp Ser Leu Glu Leu Glu Asp Gln
 225                 230                 235                 240
 Glu Arg His Phe Leu Gln Gln Ala Thr Gln Val Asn Ala Trp Asp Arg
                 245                 250                 255    
 Thr Leu Ile Glu Asn Gly Glu Lys Ile Thr Ser Leu His Arg Glu Val
             260                 265                 270        
 Glu Lys Val Lys Leu Asp Gln Lys Arg Leu Asp Gln Glu Leu Asp Phe
         275                 280                 285            
 Ile Leu Ser Gln Gln Lys Glu Leu Glu Asp Leu Leu Ser Pro Leu Glu
     290                 295                 300                
 Glu Leu Val Lys Glu Gln Ser Gly Thr Ile Tyr Leu Gln His Ala Asp
 305                 310                 315                 320
 Glu Glu Arg Glu Lys Thr Tyr Lys Leu Ala Glu Asn Ile Asp Ala Gln
                 325                 330                 335    
 Leu Lys Arg Met Ala Gln Asp Leu Lys Asp Ile Ile Glu His Leu Asn
             340                 345                 350        
 Thr Ser Gly Ala Pro Ala Asp Thr Ser Asp Pro Leu Gln Gln Ile Cys
         355                 360                 365            
 Lys Ile Leu Asn Ala His Met Asp Ser Leu Gln Trp Ile Asp Gln Asn
     370                 375                 380                
 Ser Ala Leu Leu Gln Arg Lys Val Glu Glu Val Thr Lys Val Cys Glu
 385                 390                 395                 400
 Gly Arg Arg Lys Glu Gln Glu Arg Ser Phe Arg Ile Thr Phe Asp
                 405                 410                 415



      <210> 213
      <211> 665
      <212> PRT
      <213> Homo sapiens


      <400> 213
 Met Lys Arg Arg Asn Ala Asp Cys Ser Lys Leu Arg Arg Pro Leu Lys
   1               5                  10                  15    
 Arg Asn Arg Ile Thr Glu Gly Ile Tyr Gly Ser Thr Phe Leu Tyr Leu
              20                  25                  30        
 Lys Phe Leu Val Val Trp Ala Leu Val Leu Leu Ala Asp Phe Val Leu
          35                  40                  45            
 Glu Phe Arg Phe Glu Tyr Leu Trp Pro Phe Trp Leu Phe Ile Arg Ser
      50                  55                  60                
 Val Tyr Asp Ser Phe Arg Tyr Gln Gly Leu Ala Phe Ser Val Phe Phe
  65                  70                  75                  80
 Val Cys Val Ala Phe Thr Ser Asn Ile Ile Cys Leu Leu Phe Ile Pro
                  85                  90                  95    
 Ile Gln Trp Leu Phe Phe Ala Ala Ser Thr Tyr Val Trp Val Gln Tyr
             100                 105                 110        
 Val Trp His Thr Glu Arg Gly Val Cys Leu Pro Thr Val Ser Leu Trp
         115                 120                 125            
 Ile Leu Phe Val Tyr Ile Glu Ala Ala Ile Arg Phe Lys Asp Leu Lys
     130                 135                 140                
 Asn Phe His Val Asp Leu Cys Arg Pro Phe Ala Ala His Cys Ile Gly
 145                 150                 155                 160
 Tyr Pro Val Val Thr Leu Gly Phe Gly Phe Lys Ser Tyr Val Ser Tyr
                 165                 170                 175    
 Lys Met Arg Leu Arg Lys Gln Lys Glu Val Gln Lys Glu Asn Glu Phe
             180                 185                 190        
 Tyr Met Gln Leu Leu Gln Gln Ala Leu Pro Pro Glu Gln Gln Met Leu
         195                 200                 205            
 Gln Lys Gln Glu Lys Glu Ala Glu Glu Ala Ala Lys Gly Leu Pro Asp
     210                 215                 220                
 Met Asp Ser Ser Ile Leu Ile His His Asn Gly Gly Ile Pro Ala Asn
 225                 230                 235                 240
 Lys Lys Leu Ser Thr Thr Leu Pro Glu Ile Glu Tyr Arg Glu Lys Gly
                 245                 250                 255    
 Lys Glu Lys Asp Lys Asp Ala Lys Lys His Asn Leu Gly Ile Asn Asn
             260                 265                 270        
 Asn Asn Ile Leu Gln Pro Val Asp Ser Lys Ile Gln Glu Ile Glu Tyr
         275                 280                 285            
 Met Glu Asn His Ile Asn Ser Lys Arg Leu Asn Asn Asp Leu Val Gly
     290                 295                 300                
 Ser Thr Glu Asn Leu Leu Lys Glu Asp Ser Cys Thr Ala Ser Ser Lys
 305                 310                 315                 320
 Asn Tyr Lys Asn Ala Ser Gly Val Val Asn Ser Ser Pro Arg Ser His
                 325                 330                 335    
 Ser Ala Thr Asn Gly Ser Ile Pro Ser Ser Ser Ser Lys Asn Glu Lys
             340                 345                 350        
 Lys Gln Lys Cys Thr Ser Lys Ser Pro Ser Thr His Lys Asp Leu Met
         355                 360                 365            
 Glu Asn Cys Ile Pro Asn Asn Gln Leu Ser Lys Pro Asp Ala Leu Val
     370                 375                 380                
 Arg Leu Glu Gln Asp Ile Lys Lys Leu Lys Ala Asp Leu Gln Ala Ser
 385                 390                 395                 400
 Arg Gln Val Glu Gln Glu Leu Arg Ser Gln Ile Ser Ser Leu Ser Ser
                 405                 410                 415    
 Thr Glu Arg Gly Ile Arg Ser Glu Met Gly Gln Leu Arg Gln Glu Asn
             420                 425                 430        
 Glu Leu Leu Gln Asn Lys Leu His Asn Ala Val Gln Met Lys Gln Lys
         435                 440                 445            
 Asp Lys Gln Asn Ile Ser Gln Leu Glu Lys Lys Leu Lys Ala Glu Gln
     450                 455                 460                
 Glu Ala Arg Ser Phe Val Glu Lys Gln Leu Met Glu Glu Lys Lys Arg
 465                 470                 475                 480
 Lys Lys Leu Glu Glu Ala Thr Ala Ala Arg Ala Val Ala Phe Ala Ala
                 485                 490                 495    
 Ala Ser Arg Gly Glu Cys Thr Glu Thr Leu Arg Asn Arg Ile Arg Glu
             500                 505                 510        
 Leu Glu Ala Glu Gly Lys Lys Leu Thr Met Asp Met Lys Val Lys Glu
         515                 520                 525            
 Asp Gln Ile Arg Glu Leu Glu Leu Lys Val Gln Glu Leu Arg Lys Tyr
     530                 535                 540                
 Lys Glu Asn Glu Lys Asp Thr Glu Val Leu Met Ser Ala Leu Ser Ala
 545                 550                 555                 560
 Met Gln Asp Lys Thr Gln His Leu Glu Asn Ser Leu Ser Ala Glu Thr
                 565                 570                 575    
 Arg Ile Lys Leu Asp Leu Phe Ser Ala Leu Gly Asp Ala Lys Arg Gln
             580                 585                 590        
 Leu Glu Ile Ala Gln Gly Gln Ile Leu Gln Lys Asp Gln Glu Ile Lys
         595                 600                 605            
 Asp Leu Lys Gln Lys Ile Ala Glu Val Met Ala Val Met Pro Ser Ile
     610                 615                 620                
 Thr Tyr Ser Ala Ala Thr Ser Pro Leu Ser Pro Val Ser Pro His Tyr
 625                 630                 635                 640
 Ser Ser Lys Phe Val Glu Thr Ser Pro Ser Gly Leu Asp Pro Asn Ala
                 645                 650                 655    
 Ser Val Tyr Gln Pro Leu Lys Lys
             660                



      <210> 214
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 214
 Met Ile Ser Ser Cys Thr Thr Arg Lys Met Ala Glu Glu Glu Gln Arg
   1               5                  10                  15    
 Lys Ile Pro Leu Val Pro Glu Asn Leu Leu Lys Lys Arg Lys Ala Tyr
              20                  25                  30        
 Gln Ala Leu Lys Ala Thr Gln Ala Lys Gln Ala Leu Leu Ala Lys Lys
          35                  40                  45            
 Glu Gln Lys Lys Gly Lys Gly Leu Arg Phe Lys Arg Leu Glu Ser Phe
      50                  55                  60                
 Leu His Asp Ser Trp Arg Gln Lys Arg Asp Lys Val Arg Leu Arg Arg
  65                  70                  75                  80
 Leu Glu Val Lys Pro His Ala Leu Glu Leu Pro Asp Lys His Ser Leu
                  85                  90                  95    
 Ala Phe Val Val Arg Ile Glu Arg Ile Asp Gly Val Ser Leu Leu Val
             100                 105                 110        
 Gln Arg Thr Ile Ala Arg Leu Arg Leu Lys Lys Ile Phe Ser Gly Val
         115                 120                 125            
 Phe Val Lys Val Thr Pro Gln Asn Leu Lys Met Leu Arg Ile Val Glu
     130                 135                 140                
 Pro Tyr Val Thr Trp Gly Phe Pro Asn Leu Lys Ser Val Arg Glu Leu
 145                 150                 155                 160
 Ile Leu Lys Arg Gly Gln Ala Lys Val Lys Asn Lys Thr Ile Pro Leu
                 165                 170                 175    
 Thr Asp Asn Thr Val Ile Glu Glu His Leu Gly Lys Phe Gly Val Ile
             180                 185                 190        
 Cys Leu Glu Asp Leu Ile His Glu Ile Ala Phe Pro Gly Lys His Phe
         195                 200                 205            
 Gln Glu Ile Ser Trp Phe Leu Cys Pro Phe His Leu Ser Val Ala Arg
     210                 215                 220                
 His Ala Thr Lys Asn Arg Val Gly Phe Leu Lys Glu Met Gly Thr Pro
 225                 230                 235                 240
 Gly Tyr Arg Gly Glu Arg Ile Asn Gln Leu Ile Arg Gln Leu Asn
                 245                 250                 255



      <210> 215
      <211> 614
      <212> PRT
      <213> Homo sapiens


      <400> 215
 Met Ala Ala Thr Ala Val Ala Ala Ala Val Ala Gly Thr Glu Ser Ala
   1               5                  10                  15    
 Gln Gly Pro Pro Gly Pro Ala Ala Ser Leu Glu Leu Trp Leu Asn Lys
              20                  25                  30        
 Ala Thr Asp Pro Ser Met Ser Glu Gln Asp Trp Ser Ala Ile Gln Asn
          35                  40                  45            
 Phe Cys Glu Gln Val Asn Thr Asp Pro Asn Gly Pro Thr His Ala Pro
      50                  55                  60                
 Trp Leu Leu Ala His Lys Ile Gln Ser Pro Gln Glu Lys Glu Ala Leu
  65                  70                  75                  80
 Tyr Ala Leu Thr Val Leu Glu Met Cys Met Asn His Cys Gly Glu Lys
                  85                  90                  95    
 Phe His Ser Glu Val Ala Lys Phe Arg Phe Leu Asn Glu Leu Ile Lys
             100                 105                 110        
 Val Leu Ser Pro Lys Tyr Leu Gly Ser Trp Ala Thr Gly Lys Val Lys
         115                 120                 125            
 Gly Arg Val Ile Glu Ile Leu Phe Ser Trp Thr Val Trp Phe Pro Glu
     130                 135                 140                
 Asp Ile Lys Ile Arg Asp Ala Tyr Gln Met Leu Lys Lys Gln Gly Ile
 145                 150                 155                 160
 Ile Lys Gln Asp Pro Lys Leu Pro Val Asp Lys Ile Leu Pro Pro Pro
                 165                 170                 175    
 Ser Pro Trp Pro Lys Ser Ser Ile Phe Asp Ala Asp Glu Glu Lys Ser
             180                 185                 190        
 Lys Leu Leu Thr Arg Leu Leu Lys Ser Asn His Pro Glu Asp Leu Gln
         195                 200                 205            
 Ala Ala Asn Arg Leu Ile Lys Asn Leu Val Lys Glu Glu Gln Glu Lys
     210                 215                 220                
 Ser Glu Lys Val Ser Lys Arg Val Ser Ala Val Glu Glu Val Arg Ser
 225                 230                 235                 240
 His Val Lys Val Leu Gln Glu Met Leu Ser Met Tyr Arg Arg Pro Gly
                 245                 250                 255    
 Gln Ala Pro Pro Asp Gln Glu Ala Leu Gln Val Val Tyr Glu Arg Cys
             260                 265                 270        
 Glu Lys Leu Arg Pro Thr Leu Phe Arg Leu Ala Ser Asp Thr Thr Asp
         275                 280                 285            
 Asp Asp Asp Ala Leu Ala Glu Ile Leu Gln Ala Asn Asp Leu Leu Thr
     290                 295                 300                
 Gln Gly Val Leu Leu Tyr Lys Gln Val Met Glu Gly Arg Val Thr Phe
 305                 310                 315                 320
 Gly Asn Arg Val Thr Ser Ser Leu Gly Asp Ile Pro Val Ser Arg Val
                 325                 330                 335    
 Phe Gln Asn Pro Ala Gly Cys Met Lys Thr Cys Pro Leu Ile Asp Leu
             340                 345                 350        
 Glu Val Asp Asn Gly Pro Ala Gln Met Gly Thr Val Val Pro Ser Leu
         355                 360                 365            
 Leu His Gln Asp Leu Ala Ala Leu Gly Ile Ser Asp Ala Pro Val Thr
     370                 375                 380                
 Gly Met Val Ser Gly Gln Asn Cys Cys Glu Glu Lys Arg Asn Pro Ser
 385                 390                 395                 400
 Ser Ser Thr Leu Pro Gly Gly Gly Val Gln Asn Pro Ser Ala Asp Arg
                 405                 410                 415    
 Asn Leu Leu Asp Leu Leu Ser Pro Gln Pro Ala Pro Cys Pro Leu Asn
             420                 425                 430        
 Tyr Val Ser Gln Lys Ser Val Pro Lys Glu Val Pro Pro Gly Thr Lys
         435                 440                 445            
 Ser Ser Pro Gly Trp Ser Trp Glu Ala Gly Pro Leu Ala Pro Ser Pro
     450                 455                 460                
 Ser Ser Gln Asn Thr Pro Leu Ala Gln Val Phe Val Pro Leu Glu Ser
 465                 470                 475                 480
 Val Lys Pro Ser Ser Leu Pro Pro Leu Ile Val Tyr Asp Arg Asn Gly
                 485                 490                 495    
 Phe Arg Ile Leu Leu His Phe Ser Gln Thr Gly Ala Pro Gly His Pro
             500                 505                 510        
 Glu Val Gln Val Leu Leu Leu Thr Met Met Ser Thr Ala Pro Gln Pro
         515                 520                 525            
 Val Trp Asp Ile Met Phe Gln Val Ala Val Pro Lys Ser Met Arg Val
     530                 535                 540                
 Lys Leu Gln Pro Ala Ser Ser Ser Lys Leu Pro Ala Phe Ser Pro Leu
 545                 550                 555                 560
 Met Pro Pro Ala Val Ile Ser Gln Met Leu Leu Leu Asp Asn Pro His
                 565                 570                 575    
 Lys Glu Pro Ile Arg Leu Arg Tyr Lys Leu Thr Phe Asn Gln Gly Gly
             580                 585                 590        
 Gln Pro Phe Ser Glu Val Gly Glu Val Lys Asp Phe Pro Asp Leu Ala
         595                 600                 605            
 Val Leu Gly Ala Ala
     610            



      <210> 216
      <211> 313
      <212> PRT
      <213> Homo sapiens


      <400> 216
 Met Trp Ser Glu Gly Arg Tyr Glu Tyr Glu Arg Ile Pro Arg Glu Arg
   1               5                  10                  15    
 Ala Pro Pro Arg Ser His Pro Ser Asp Glu Ser Gly Tyr Arg Trp Thr
              20                  25                  30        
 Arg Asp Asp His Ser Ala Ser Arg Gln Pro Glu Tyr Arg Asp Met Arg
          35                  40                  45            
 Asp Gly Phe Arg Arg Lys Ser Phe Tyr Ser Ser His Tyr Ala Arg Glu
      50                  55                  60                
 Arg Ser Pro Tyr Lys Arg Asp Asn Thr Phe Phe Arg Glu Ser Pro Val
  65                  70                  75                  80
 Gly Arg Lys Asp Ser Pro His Ser Arg Ser Gly Ser Ser Val Ser Ser
                  85                  90                  95    
 Arg Ser Tyr Ser Pro Glu Arg Ser Lys Ser Tyr Ser Phe His Gln Ser
             100                 105                 110        
 Gln His Arg Lys Ser Val Arg Pro Gly Ala Ser Tyr Lys Arg Gln Asn
         115                 120                 125            
 Glu Gly Asn Pro Glu Arg Asp Lys Glu Arg Pro Val Gln Ser Leu Lys
     130                 135                 140                
 Thr Ser Arg Asp Thr Ser Pro Ser Ser Gly Ser Ala Val Ser Ser Ser
 145                 150                 155                 160
 Lys Val Leu Asp Lys Pro Ser Arg Leu Thr Glu Lys Glu Leu Ala Glu
                 165                 170                 175    
 Ala Ala Ser Lys Trp Ala Ala Glu Lys Leu Glu Lys Ser Asp Glu Ser
             180                 185                 190        
 Asn Leu Pro Glu Ile Ser Glu Tyr Glu Ala Gly Ser Thr Ala Pro Leu
         195                 200                 205            
 Phe Thr Asp Gln Pro Glu Glu Pro Glu Ser Asn Thr Thr His Gly Ile
     210                 215                 220                
 Glu Leu Phe Glu Asp Ser Gln Leu Thr Thr Arg Ser Lys Ala Ile Ala
 225                 230                 235                 240
 Ser Lys Thr Lys Glu Ile Glu Gln Val Tyr Arg Gln Asp Cys Glu Thr
                 245                 250                 255    
 Phe Gly Met Val Val Lys Met Leu Ile Glu Lys Asp Pro Ser Leu Glu
             260                 265                 270        
 Lys Ser Ile Gln Phe Ala Leu Arg Gln Asn Leu His Glu Ile Gly Glu
         275                 280                 285            
 Arg Cys Val Glu Glu Leu Lys His Phe Ile Ala Glu Tyr Asp Thr Ser
     290                 295                 300                
 Thr Gln Asp Phe Gly Glu Pro Phe
 305                 310        



      <210> 217
      <211> 579
      <212> PRT
      <213> Homo sapiens


      <400> 217
 Met Ala His Ser Leu Ser Val Gly Gly Ser Gly Tyr Val Cys Pro Leu
   1               5                  10                  15    
 Leu Ile Arg Glu Val Phe Ile Gln Val Leu Ile Lys Leu Arg Val Cys
              20                  25                  30        
 Phe Val Gln Cys Phe Ser Glu Ala Asp Arg Asp Ile Met Thr Leu Ala
          35                  40                  45            
 Asn His Trp Asn Cys Pro Val Leu Ser Ser Asp Ser Asp Phe Cys Ile
      50                  55                  60                
 Phe Asp Leu Lys Thr Gly Phe Cys Pro Leu Asn Ser Phe Gln Trp Arg
  65                  70                  75                  80
 Asn Met Asn Thr Ile Lys Gly Thr Gln Asn Tyr Ile Pro Ala Lys Cys
                  85                  90                  95    
 Phe Ser Leu Asp Ala Phe Cys His His Phe Ser Asn Met Asn Lys Ala
             100                 105                 110        
 Leu Leu Pro Leu Phe Ala Val Leu Cys Gly Asn Asp His Val Asn Leu
         115                 120                 125            
 Pro Ile Met Glu Thr Phe Leu Ser Lys Ala Arg Leu Pro Leu Gly Ala
     130                 135                 140                
 Thr Ser Ser Lys Gly Arg Arg His His Arg Ile Leu Gly Leu Leu Asn
 145                 150                 155                 160
 Trp Leu Ser His Phe Ala Asn Pro Thr Glu Ala Leu Asp Asn Val Leu
                 165                 170                 175    
 Lys Tyr Leu Pro Lys Lys Asp Arg Glu Asn Val Lys Glu Leu Leu Cys
             180                 185                 190        
 Cys Ser Met Glu Glu Tyr Gln Gln Ser Gln Val Lys Leu Gln Asp Phe
         195                 200                 205            
 Phe Gln Cys Gly Thr Tyr Val Cys Pro Asp Ala Leu Asn Leu Gly Leu
     210                 215                 220                
 Pro Glu Trp Val Leu Val Ala Leu Ala Lys Gly Gln Leu Ser Pro Phe
 225                 230                 235                 240
 Ile Ser Asp Ala Leu Val Leu Arg Arg Thr Ile Leu Pro Thr Gln Val
                 245                 250                 255    
 Glu Asn Met Gln Gln Pro Asn Ala His Arg Ile Ser Gln Pro Ile Arg
             260                 265                 270        
 Gln Ile Ile Tyr Gly Leu Leu Leu Asn Ala Ser Pro His Leu Asp Lys
         275                 280                 285            
 Thr Ser Trp Asn Ala Leu Pro Pro Gln Pro Leu Ala Phe Ser Glu Val
     290                 295                 300                
 Glu Arg Ile Asn Lys Asn Ile Arg Thr Ser Ile Ile Asp Ala Val Glu
 305                 310                 315                 320
 Leu Ala Lys Asp His Ser Asp Leu Ser Arg Leu Thr Glu Leu Ser Leu
                 325                 330                 335    
 Arg Arg Arg Gln Met Leu Leu Leu Glu Thr Leu Lys Val Lys Gln Thr
             340                 345                 350        
 Ile Leu Glu Pro Ile Pro Thr Ser Leu Lys Leu Pro Ile Ala Val Ser
         355                 360                 365            
 Cys Tyr Trp Leu Gln His Thr Glu Thr Lys Ala Lys Leu His His Leu
     370                 375                 380                
 Gln Ser Leu Leu Leu Thr Met Leu Val Gly Pro Leu Ile Ala Ile Ile
 385                 390                 395                 400
 Asn Ser Pro Gly Lys Glu Glu Leu Gln Glu Asp Gly Ala Lys Met Leu
                 405                 410                 415    
 Tyr Ala Glu Phe Gln Arg Val Lys Ala Gln Thr Arg Leu Gly Thr Arg
             420                 425                 430        
 Leu Asp Leu Asp Thr Ala His Ile Phe Cys Gln Trp Gln Ser Cys Leu
         435                 440                 445            
 Gln Met Gly Met Tyr Leu Asn Gln Leu Leu Ser Thr Pro Leu Pro Glu
     450                 455                 460                
 Pro Asp Leu Thr Arg Leu Tyr Ser Gly Ser Leu Val His Gly Leu Cys
 465                 470                 475                 480
 Gln Gln Leu Leu Ala Ser Thr Ser Val Glu Ser Leu Leu Ser Ile Cys
                 485                 490                 495    
 Pro Glu Ala Lys Gln Leu Tyr Glu Tyr Leu Phe Asn Ala Thr Arg Ser
             500                 505                 510        
 Tyr Ala Pro Ala Glu Ile Phe Leu Pro Lys Gly Arg Ser Asn Ser Lys
         515                 520                 525            
 Lys Lys Arg Gln Lys Lys Gln Asn Thr Ser Cys Ser Lys Asn Arg Gly
     530                 535                 540                
 Arg Thr Thr Ala His Thr Lys Cys Trp Tyr Glu Gly Asn Asn Arg Phe
 545                 550                 555                 560
 Gly Leu Leu Met Val Glu Asn Leu Glu Glu His Ser Glu Ala Ser Asn
                 565                 570                 575    
 Ile Glu
        



      <210> 218
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 218
 Met Ile Gly Ile Val Ile Thr Val Ile Pro His Ile Asn Thr Ala Phe
   1               5                  10                  15    
 Leu Pro Lys Lys Lys Gln Leu Ser Thr Asn Thr Lys Lys Arg Ser Pro
              20                  25                  30        
 Ser Phe Leu Ser Leu Leu Ser Leu Cys Val Cys Val Cys Val Cys Val
          35                  40                  45            
 Cys Val Cys Val Cys Val Cys Leu Phe Leu Cys Leu
      50                  55                  60



      <210> 219
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 219
 Met Phe Met Thr Ser Lys Glu Thr Phe Thr His Tyr Gln Pro Gln Gly
   1               5                  10                  15    
 Asn Ser Asp Pro Ala His Thr Ala Thr Ala Pro Gly Gly Leu Ser Ala
              20                  25                  30        
 Lys Ala Pro Ala Met Thr Pro Leu Met Leu Asp Thr Ser Ser Arg Lys
          35                  40                  45            
 Leu Val Ala Trp Asp Gly Thr Thr Asp Gly Ala Ala Val Gly Ile Leu
      50                  55                  60                
 Ala Val Ala Ala Asp Gln Thr Ser Thr Thr Leu Thr Phe Tyr Lys Ser
  65                  70                  75                  80
 Gly Thr Phe Arg Tyr Glu Asp Val Leu Trp Pro Glu Ala Ala Ser Asp
                  85                  90                  95    
 Lys Thr Lys Lys Arg Thr Ala Phe Ala Gly Thr Ala Ile Ser Ile Val
             100                 105                 110        





      <210> 220
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 220
 Met Asp Glu Glu Leu Leu His Arg Asp Glu Gln Arg Lys Trp Phe Leu
   1               5                  10                  15    
 Glu Met Arg Ser Thr Pro Gly Glu Asp Ala Ala Asn Asn Val Glu Met
              20                  25                  30        
 Thr Thr Lys Asp Leu Asn Tyr Asp Arg Asn Leu Val Asp Lys Ala Val
          35                  40                  45            
 Val Gly Phe Glu Arg Thr Asp Ser Asn Phe Glu Arg Ser Cys Thr Val
      50                  55                  60                
 Gly Lys Gln His Cys Met Ile Gln Arg Asn Cys Ser Trp Lys Glu Glu
  65                  70                  75                  80
 Tyr Met Asp Ala Ala Asn Phe Ile Val Val Leu Phe
                  85                  90        



      <210> 221
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 221
 Met Val Glu Ile Asn Asn Gln Arg Lys Ala Phe Leu Asp Met Leu Ala
   1               5                  10                  15    
 Trp Ser Glu Gly Thr Asp Asn Gly Arg Gln Lys Thr Arg Asn His Gly
              20                  25                  30        
 Tyr Asp Val Ile Val Gly Gly Glu Leu Phe Thr Asp Tyr Ser Asp His
          35                  40                  45            
 Pro Arg Lys Leu Val Thr Leu Asn Pro Lys Leu Lys Ser Thr Gly Ala
      50                  55                  60                
 Gly Arg Tyr Gln Leu Leu Ser Arg Trp Trp Asp Ala Tyr Arg Lys Gln
  65                  70                  75                  80
 Leu Gly Leu Lys Asp Phe Ser Pro Lys Ser Gln Asp Ala Val Ala Leu
                  85                  90                  95    
 Gln Gln Ile Lys Glu Arg Gly Ala Leu Pro Met Ile Asp Arg Gly Asp
             100                 105                 110        
 Ile Arg Gln Ala Ile Asp Arg Cys Ser Asn Ile Trp Ala Ser Leu Pro
         115                 120                 125            
 Gly Ala Gly Tyr Gly Gln Phe Glu His Lys Ala Asp Ser Leu Ile Ala
     130                 135                 140                
 Lys Phe Lys Glu Ala Gly Gly Thr Val Arg Glu Ile Asp Val
 145                 150                 155            



      <210> 222
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 222
 Met Ala Ala Ala Ala Leu Arg Pro Pro Ala Gln Gly Thr Val Thr Phe
   1               5                  10                  15    
 Glu Asp Val Ala Val Asn Phe Ser Gln Glu Glu Trp Ser Leu Leu Ser
              20                  25                  30        
 Glu Ala Gln Arg Cys Leu Tyr His Asp Val Met Leu Glu Asn Leu Thr
          35                  40                  45            
 Leu Ile Ser Ser Leu Gly Cys Trp Tyr Gly Ala Lys Asp Glu Thr Pro
      50                  55                  60                
 Ser Lys Gln Thr Leu Ser Ile Gln Gln Glu Ser Pro Leu Arg Thr His
  65                  70                  75                  80
 Trp Thr Gly Val Cys Thr Lys Lys Val His Leu Trp Gly Met Cys Gly
                  85                  90                  95    
 Pro Leu Leu Gly Asp Ile Leu His Gln Gly Thr Gln His Asn Gln Lys
             100                 105                 110        
 Leu Asn Gly Phe Gly Ala Tyr Glu Lys Lys Leu Asp Asp Asp Ala Asn
         115                 120                 125            
 His His Gln Asp Gln Lys Gln His Ile Gly Glu Lys Ser Tyr Arg Ser
     130                 135                 140                
 Asn Ala Lys Gly Thr Ser Phe Val Lys Asn Cys Lys Phe His Met Ser
 145                 150                 155                 160
 His Glu Pro Phe Ile Phe His Glu Val Gly Lys Asp Phe Leu Ser Ser
                 165                 170                 175    
 Leu Arg Leu Leu Gln Gln Glu Asp Ile His Thr Ser Gly Lys Ser Asp
             180                 185                 190        
 Phe Glu Thr Lys His Gly Ile Pro Leu Gln Gly Gly Lys Thr His Tyr
         195                 200                 205            
 Ile Cys Gly Glu Ser Thr Tyr Arg Leu Ala Thr Asn Thr Pro Leu Phe
     210                 215                 220                
 Leu His Gln Arg Leu Pro Pro Arg Gly Arg Thr Leu Cys Met Gln
 225                 230                 235                



      <210> 223
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 223
 Met Ala Arg Glu Pro Arg Lys Asn Ala Ala Leu Asp Ala Gln Ser Ala
   1               5                  10                  15    
 Glu Asp Gln Thr Gly Phe Leu Thr Val Lys Val Glu Lys Glu Glu Ala
              20                  25                  30        
 Phe Ala Leu Thr Ala Glu Val Arg Ala Pro Cys Ser Pro Ala Arg Gly
          35                  40                  45            
 Pro Glu Arg Ser Arg Gln Arg Phe Arg Gly Phe Arg Tyr Pro Glu Ala
      50                  55                  60                
 Ala Gly Pro Arg Glu Ala Leu Ser Arg Leu Arg Glu Leu Cys Gly Gln
  65                  70                  75                  80
 Trp Leu Gln Pro Glu Met His Ser Lys Glu Gln Ile Leu Glu Leu Leu
                  85                  90                  95    
 Val Leu Glu Gln Phe Leu Thr Ile Leu Pro Gly Asn Leu Gln Ser Trp
             100                 105                 110        
 Val Arg Glu Gln His Pro Glu Ser Gly Glu Glu Val Val Val Leu Leu
         115                 120                 125            
 Glu Tyr Leu Glu Arg Gln Leu Asp Glu Pro Ala Pro Gln Val Glu Arg
     130                 135                 140                
 Thr Gly Leu Val Ser Glu Arg Cys Gly Leu Phe Pro Pro Glu Ile Pro
 145                 150                 155                 160
 Asp Arg Ser Glu Gly His Ser Phe Lys Val Gln Glu Phe Phe Ile Ser
                 165                 170                 175    
 Phe Cys Thr Val Asn Leu Leu Gly Ser Lys Gly Leu Leu Lys Met Glu
             180                 185                 190        
 Asp Val Ala Leu Thr Leu Thr Pro Gly Trp Thr Gln Leu Asp Ser Ser
         195                 200                 205            
 Gln Val Asn Leu Tyr Arg Asp Glu Lys Gln Glu Asn His Ser Ser Leu
     210                 215                 220                
 Val Ser Leu Gly Gly Glu Ile Gln Thr Lys Ser Arg Asp Leu Pro Pro
 225                 230                 235                 240
 Val Lys Lys Leu Pro Glu Lys Glu His Gly Lys Ile Cys His Leu Arg
                 245                 250                 255    
 Glu Asp Ile Ala Gln Ile Pro Thr His Ala Glu Ala Gly Glu Gln Glu
             260                 265                 270        
 Gly Arg Leu Gln Arg Lys Gln Lys Asn Ala Ile Gly Ser Arg Arg His
         275                 280                 285            
 Tyr Cys His Glu Cys Gly Lys Ser Phe Ala Gln Ser Ser Gly Leu Thr
     290                 295                 300                
 Lys His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Glu Asp
 305                 310                 315                 320
 Cys Gly Lys Thr Phe Ile Gly Ser Ser Ala Leu Val Ile His Gln Arg
                 325                 330                 335    
 Val His Thr Gly Glu Lys Pro Tyr Glu Cys Glu Glu Cys Gly Lys Val
             340                 345                 350        
 Phe Ser His Ser Ser Asn Leu Ile Lys His Gln Arg Thr His Thr Gly
         355                 360                 365            
 Glu Lys Pro Tyr Glu Cys Asp Asp Cys Gly Lys Thr Phe Ser Gln Ser
     370                 375                 380                
 Cys Ser Leu Leu Glu His His Lys Ile His Thr Gly Glu Lys Pro Tyr
 385                 390                 395                 400
 Gln Cys Asn Met Cys Gly Lys Ala Phe Arg Arg Asn Ser His Leu Leu
                 405                 410                 415    
 Arg His Gln Arg Ile His Gly Asp Lys Asn Val Gln Asn Pro Glu His
             420                 425                 430        
 Gly Glu Ser Trp Glu Ser Gln Gly Arg Thr Glu Ser Gln Trp Glu Asn
         435                 440                 445            
 Thr Glu Ala Pro Val Ser Tyr Lys Cys Asn Glu Cys Glu Arg Ser Phe
     450                 455                 460                
 Thr Arg Asn Arg Ser Leu Ile Glu His Gln Lys Ile His Thr Gly Glu
 465                 470                 475                 480
 Lys Pro Tyr Gln Cys Asp Thr Cys Gly Lys Gly Phe Thr Arg Thr Ser
                 485                 490                 495    
 Tyr Leu Val Gln His Gln Arg Ser His Val Gly Lys Lys Thr Leu Ser
             500                 505                 510        
 Gln
    



      <210> 224
      <211> 242
      <212> PRT
      <213> Homo sapiens


      <400> 224
 Met Leu Pro Ala Val Gly Ser Ala Asp Glu Glu Glu Asp Pro Ala Glu
   1               5                  10                  15    
 Glu Asp Cys Pro Glu Leu Val Pro Met Glu Thr Thr Gln Ser Glu Glu
              20                  25                  30        
 Glu Glu Lys Ser Gly Leu Gly Ala Lys Ile Pro Val Thr Ile Ile Thr
          35                  40                  45            
 Gly Tyr Leu Gly Ala Gly Lys Thr Thr Leu Leu Asn Tyr Ile Leu Thr
      50                  55                  60                
 Glu Gln His Ser Lys Arg Val Ala Val Ile Leu Asn Glu Phe Gly Glu
  65                  70                  75                  80
 Gly Ser Ala Leu Glu Lys Ser Leu Ala Val Ser Gln Gly Gly Glu Leu
                  85                  90                  95    
 Tyr Glu Glu Trp Leu Glu Leu Arg Asn Gly Cys Leu Cys Cys Ser Val
             100                 105                 110        
 Lys Asp Asn Gly Leu Arg Ala Ile Glu Asn Leu Met Gln Lys Lys Gly
         115                 120                 125            
 Lys Phe Asp Tyr Ile Leu Leu Glu Thr Thr Gly Leu Ala Asp Pro Gly
     130                 135                 140                
 Ala Val Ala Ser Met Phe Trp Val Asp Ala Glu Leu Gly Ser Asp Ile
 145                 150                 155                 160
 Tyr Leu Asp Gly Ile Ile Thr Ile Val Asp Ser Lys Tyr Gly Leu Lys
                 165                 170                 175    
 His Leu Ala Glu Glu Lys Pro Asp Gly Leu Ile Asn Glu Ala Thr Arg
             180                 185                 190        
 Gln Val Ala Leu Ala Asp Ala Ile Leu Ile Asn Lys Thr Asp Leu Val
         195                 200                 205            
 Pro Glu Glu Asp Val Lys Lys Leu Arg Ala Thr Ile Arg Ser Ile Asn
     210                 215                 220                
 Gly Leu Gly Gln Ile Leu Glu Thr Gln Arg Ser Arg Thr Ile Asn Met
 225                 230                 235                 240
 Gln
    



      <210> 225
      <211> 762
      <212> PRT
      <213> Homo sapiens


      <400> 225
 Met Ala Met Gln Glu Lys Tyr Pro Thr Glu Gly Ile Ser His Val Thr
   1               5                  10                  15    
 Ser Pro Ser Ser Asp Val Ile Gln Lys Gly Ser Ser Leu Gly Thr Glu
              20                  25                  30        
 Trp Gln Thr Pro Val Ile Ser Glu Pro Phe Arg Ser Arg Phe Ser Arg
          35                  40                  45            
 Cys Ser Ser Val Ala Asp Ser Gly Asp Thr Ala Ile Gly Thr Ser Cys
      50                  55                  60                
 Ser Asp Ile Ala Glu Asp Phe Cys Ser Ser Ser Gly Ser Pro Pro Phe
  65                  70                  75                  80
 Gln Pro Ile Lys Ser His Val Thr Ile Pro Thr Ala His Val Met Pro
                  85                  90                  95    
 Ser Thr Leu Gly Thr Ser Pro Ala Lys Pro Asn Ser Thr Pro Val Gly
             100                 105                 110        
 Pro Ser Ser Ser Lys Leu Pro Leu Ser Gly Leu Ala Glu Ser Val Gly
         115                 120                 125            
 Met Thr Arg Asn Gly Asp Leu Gly Ala Met Lys His Ser Pro Gly Leu
     130                 135                 140                
 Ser Arg Asp Leu Met Tyr Phe Ser Gly Ala Thr Gly Glu Asn Gly Ile
 145                 150                 155                 160
 Glu Gln Ser Trp Phe Pro Ala Val Gly His Glu Arg Gln Glu Glu Ala
                 165                 170                 175    
 Arg Lys Phe Asp Ile Pro Ser Met Glu Ser Thr Leu Asn Gln Ser Ala
             180                 185                 190        
 Met Met Glu Thr Leu Tyr Ser Asp Pro His His Arg Val Arg Phe His
         195                 200                 205            
 Asn Pro Arg Thr Ser Thr Ser Lys Glu Leu Tyr Arg Val Leu Pro Glu
     210                 215                 220                
 Ala Lys Lys Ala Pro Gly Ser Gly Ala Val Phe Glu Arg Asn Gly Pro
 225                 230                 235                 240
 His Ser Asn Ser Ser Gly Val Leu Pro Leu Gly Leu Gln Pro Ala Pro
                 245                 250                 255    
 Gly Leu Ser Lys Pro Leu Pro Ser Gln Val Trp Gln Pro Ser Pro Asp
             260                 265                 270        
 Thr Trp His Pro Arg Glu Gln Ser Cys Glu Leu Ser Thr Cys Arg Gln
         275                 280                 285            
 Gln Leu Glu Leu Ile Arg Leu Gln Met Glu Gln Met Gln Leu Gln Asn
     290                 295                 300                
 Gly Ala Ile Cys His His Pro Ala Ala Phe Gly Pro Ser Leu Pro Ile
 305                 310                 315                 320
 Leu Glu Pro Ala Gln Trp Ile Ser Ile Leu Asn Ser Asn Glu His Leu
                 325                 330                 335    
 Leu Lys Glu Lys Glu Leu Leu Ile Asp Lys Gln Arg Lys His Ile Ser
             340                 345                 350        
 Gln Leu Glu Gln Lys Val Arg Glu Ser Glu Leu Gln Val His Ser Ala
         355                 360                 365            
 Leu Leu Gly Arg Pro Ala Pro Phe Gly Asp Val Cys Leu Leu Arg Leu
     370                 375                 380                
 Gln Glu Leu Gln Arg Glu Asn Thr Phe Leu Arg Ala Gln Phe Ala Gln
 385                 390                 395                 400
 Lys Thr Glu Ala Leu Ser Arg Glu Lys Ile Asp Leu Glu Lys Lys Leu
                 405                 410                 415    
 Ser Ala Ser Glu Val Glu Val Gln Leu Ile Arg Glu Ser Leu Lys Val
             420                 425                 430        
 Ala Leu Gln Lys His Ser Glu Glu Val Lys Lys Gln Glu Glu Arg Val
         435                 440                 445            
 Lys Gly Arg Asp Lys His Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys
     450                 455                 460                
 Glu Ser Glu Gln Asn Arg Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu
 465                 470                 475                 480
 Arg Tyr Leu Ala Asp Leu Pro Thr Leu Glu Asp His Gln Lys Gln Ser
                 485                 490                 495    
 Gln Gln Leu Lys Asp Ser Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys
             500                 505                 510        
 Val Thr Glu Leu Glu Ser Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg
         515                 520                 525            
 Glu Lys Glu Ile Gln Leu Glu Ser Leu Arg Gln Arg Glu Ala Glu Phe
     530                 535                 540                
 Ser Ser Ala Gly His Ser Leu Gln Asp Lys Gln Ser Val Glu Glu Thr
 545                 550                 555                 560
 Ser Gly Glu Gly Pro Glu Val Glu Met Glu Ser Trp Gln Lys Arg Tyr
                 565                 570                 575    
 Asp Ser Leu Gln Lys Ile Val Glu Lys Gln Gln Gln Lys Met Asp Gln
             580                 585                 590        
 Leu Arg Ser Gln Val Gln Ser Leu Glu Gln Glu Val Ala Gln Glu Glu
         595                 600                 605            
 Gly Thr Ser Gln Ala Leu Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala
     610                 615                 620                
 Leu Gln Gln Leu Arg Thr Ala Val Lys Glu Leu Ser Val Gln Asn Gln
 625                 630                 635                 640
 Asp Leu Ile Glu Lys Asn Leu Thr Leu Gln Glu His Leu Arg Gln Ala
                 645                 650                 655    
 Gln Pro Gly Ser Pro Pro Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu
             660                 665                 670        
 Leu His Gln Glu Leu Ala Ser Cys Leu Gln Asp Leu Gln Ala Val Cys
         675                 680                 685            
 Ser Ile Val Thr Gln Arg Ala Gln Gly His Asp Pro Asn Leu Ser Leu
     690                 695                 700                
 Leu Leu Gly Ile His Ser Gln His Pro Glu Thr Gln Leu Asp Leu Gln
 705                 710                 715                 720
 Lys Pro Asp Val Ile Lys Arg Lys Leu Glu Glu Val Gln Gln Leu Arg
                 725                 730                 735    
 Arg Asp Ile Glu Asp Leu Arg Thr Thr Met Ser Asp Arg Tyr Ala Gln
             740                 745                 750        
 Asp Met Gly Glu Asn Cys Val Thr Gln
         755                 760    



      <210> 226
      <211> 1545
      <212> PRT
      <213> Homo sapiens


      <400> 226
 Met Tyr Lys Val Tyr Leu Gly Asp Ile Pro Leu Lys Thr Lys Glu Gly
   1               5                  10                  15    
 Ala Val Leu Lys Pro Glu Leu Lys Arg Asp Pro Val Ser Thr Arg Val
              20                  25                  30        
 Lys Leu Lys Ile Val Pro His Leu Leu Arg Ser Arg Gln Ala Ala Glu
          35                  40                  45            
 Thr Phe Pro Ala Asn Ile Gln Val Val Tyr Asp Gly Leu Phe Gly Thr
      50                  55                  60                
 Asn Thr Asn Ser Lys Leu Arg Thr Leu Ser Leu Gln Phe Val His His
  65                  70                  75                  80
 Ile Cys Ile Thr Cys Pro Glu Ile Lys Ile Lys Pro Leu Gly Pro Met
                  85                  90                  95    
 Leu Leu Asn Gly Leu Thr Lys Leu Ile Asn Glu Tyr Lys Glu Asp Pro
             100                 105                 110        
 Lys Leu Leu Ser Met Ala Tyr Ser Ala Val Gly Lys Leu Ser Ser Arg
         115                 120                 125            
 Met Pro His Leu Phe Thr Lys Asp Ile Ala Leu Val Gln Gln Leu Phe
     130                 135                 140                
 Glu Ala Leu Cys Lys Glu Glu Pro Glu Thr Arg Leu Ala Ile Gln Glu
 145                 150                 155                 160
 Ala Leu Ser Met Met Val Gly Ala Tyr Ser Thr Leu Glu Gly Ala Gln
                 165                 170                 175    
 Arg Thr Leu Met Glu Ala Leu Val Ala Ser Tyr Leu Ile Lys Pro Glu
             180                 185                 190        
 Val Gln Val Arg Gln Val Ala Val Lys Phe Ala Ser Thr Val Phe Pro
         195                 200                 205            
 Ser Asp His Ile Pro Ser Arg Tyr Leu Leu Leu Leu Ala Ala Gly Asp
     210                 215                 220                
 Pro Arg Glu Glu Val His Gly Glu Ala Gln Arg Val Leu Arg Cys Leu
 225                 230                 235                 240
 Pro Gly Arg Asn Arg Lys Glu Ser Thr Ser Glu Gln Met Pro Ser Phe
                 245                 250                 255    
 Pro Glu Met Val Tyr Tyr Ile Gln Glu Lys Ala Ser His Arg Met Lys
             260                 265                 270        
 Thr Pro Val Lys Tyr Met Thr Gly Thr Thr Val Leu Pro Phe Asn Pro
         275                 280                 285            
 Ala Ala Phe Gly Glu Ile Val Leu Tyr Leu Arg Met Cys Leu Ala His
     290                 295                 300                
 Ser Ala Gly Val Val Pro Thr Ser Gln Ser Leu Ala Asp Met Gln Asp
 305                 310                 315                 320
 His Ala Pro Ala Ile Gly Arg Tyr Ile Arg Thr Leu Met Ser Ser Gly
                 325                 330                 335    
 Gln Met Ala Pro Ser Ser Ser Asn Lys Ser Gly Glu Thr Asn Pro Val
             340                 345                 350        
 Gln Ile Tyr Ile Gly Leu Leu Gln Gln Leu Leu Ala Gly Val Gly Gly
         355                 360                 365            
 Leu Pro Val Met Tyr Cys Leu Leu Glu Ala Val Ser Val Tyr Pro Glu
     370                 375                 380                
 Lys Leu Ala Thr Lys Phe Val Asp Lys Thr Glu Trp Ile Lys Ser Leu
 385                 390                 395                 400
 Met Asn Asn Ser Lys Glu Glu Met Arg Glu Leu Ala Ala Leu Phe Tyr
                 405                 410                 415    
 Ser Val Val Val Ser Thr Val Ser Gly Asn Glu Leu Lys Ser Met Ile
             420                 425                 430        
 Glu Gln Leu Ile Lys Thr Thr Lys Asp Asn His Ser Pro Glu Ile Gln
         435                 440                 445            
 His Gly Ser Leu Leu Ala Leu Gly Phe Thr Val Gly Arg Tyr Leu Ala
     450                 455                 460                
 Lys Lys Lys Met Arg Met Ser Glu Gln Gln Asp Leu Glu Arg Asn Ala
 465                 470                 475                 480
 Asp Thr Leu Pro Asp Gln Glu Glu Leu Ile Gln Ser Ala Thr Glu Thr
                 485                 490                 495    
 Ile Gly Ser Phe Leu Asp Ser Thr Ser Pro Leu Leu Ala Ile Ala Ala
             500                 505                 510        
 Cys Thr Ala Leu Gly Glu Ile Gly Arg Asn Gly Pro Leu Pro Ile Pro
         515                 520                 525            
 Ser Glu Gly Ser Gly Phe Thr Lys Leu His Leu Val Glu Ser Leu Leu
     530                 535                 540                
 Ser Arg Ile Pro Ser Ser Lys Glu Thr Asn Lys Met Lys Glu Arg Ala
 545                 550                 555                 560
 Ile Gln Thr Leu Gly Tyr Phe Pro Val Gly Asp Gly Asp Phe Pro His
                 565                 570                 575    
 Gln Lys Leu Leu Leu Gln Gly Leu Met Asp Ser Val Glu Ala Lys Gln
             580                 585                 590        
 Ile Glu Leu Gln Phe Thr Ile Gly Glu Ala Ile Thr Ser Ala Ala Ile
         595                 600                 605            
 Gly Thr Ser Ser Val Ala Ala Arg Asp Ala Trp Gln Met Thr Glu Glu
     610                 615                 620                
 Glu Tyr Thr Pro Pro Ala Gly Ala Lys Val Asn Asp Val Val Pro Trp
 625                 630                 635                 640
 Val Leu Asp Val Ile Leu Asn Lys His Ile Ile Ser Pro Asn Pro His
                 645                 650                 655    
 Val Arg Gln Ala Ala Cys Ile Trp Leu Leu Ser Leu Val Arg Lys Leu
             660                 665                 670        
 Ser Thr His Lys Glu Val Lys Ser His Leu Lys Glu Ile Gln Ser Ala
         675                 680                 685            
 Phe Val Ser Val Leu Ser Glu Asn Asp Glu Leu Ser Gln Asp Val Ala
     690                 695                 700                
 Ser Lys Gly Leu Gly Leu Val Tyr Glu Leu Gly Asn Glu Gln Asp Gln
 705                 710                 715                 720
 Gln Glu Leu Val Ser Thr Leu Val Glu Thr Leu Met Thr Gly Lys Arg
                 725                 730                 735    
 Val Lys His Glu Val Ser Gly Glu Thr Val Val Phe Gln Gly Gly Ala
             740                 745                 750        
 Leu Gly Lys Thr Pro Asp Gly Gln Gly Leu Ser Thr Tyr Lys Glu Leu
         755                 760                 765            
 Cys Ser Leu Ala Ser Asp Leu Ser Gln Pro Asp Leu Val Tyr Lys Phe
     770                 775                 780                
 Met Asn Leu Ala Asn His His Ala Met Trp Asn Ser Arg Lys Gly Ala
 785                 790                 795                 800
 Ala Phe Gly Phe Asn Val Ile Ala Thr Arg Ala Gly Glu Gln Leu Ala
                 805                 810                 815    
 Pro Phe Leu Pro Gln Leu Val Pro Arg Leu Tyr Arg Tyr Gln Phe Asp
             820                 825                 830        
 Pro Asn Leu Gly Ile Arg Gln Ala Met Thr Ser Ile Trp Asn Ala Leu
         835                 840                 845            
 Val Thr Asp Lys Ser Met Val Asp Lys Tyr Leu Lys Glu Ile Leu Gln
     850                 855                 860                
 Asp Leu Val Lys Asn Leu Thr Ser Asn Met Trp Arg Val Arg Glu Ser
 865                 870                 875                 880
 Ser Cys Leu Ala Leu Asn Asp Leu Leu Arg Gly Arg Pro Leu Asp Asp
                 885                 890                 895    
 Ile Ile Asp Lys Leu Pro Glu Ile Trp Glu Thr Leu Phe Arg Val Gln
             900                 905                 910        
 Asp Asp Ile Lys Glu Ser Val Arg Lys Ala Ala Glu Leu Ala Leu Lys
         915                 920                 925            
 Thr Leu Ser Lys Val Cys Val Lys Met Cys Asp Pro Ala Lys Gly Ala
     930                 935                 940                
 Ala Gly Gln Arg Thr Ile Ala Ala Leu Leu Pro Cys Leu Leu Asp Lys
 945                 950                 955                 960
 Gly Met Met Ser Thr Val Thr Glu Val Arg Ala Leu Ser Ile Asn Thr
                 965                 970                 975    
 Leu Val Lys Ile Ser Lys Ser Ala Gly Ala Met Leu Lys Pro His Ala
             980                 985                 990        
 Pro Lys Leu Ile Pro Ala Leu Leu Glu Ser Leu Ser Val Leu Glu Pro
         995                1000                1005            
 Gln Val Leu Asn Tyr Leu Ser Leu Arg Ala Thr Glu Gln Glu Lys Ala
    1010                1015                1020                
 Ala Met Asp Ser Ala Arg Leu Ser Ala Ala Lys Ser Ser Pro Met Met
1025                1030                1035                1040
 Glu Thr Ile Asn Met Cys Leu Gln Tyr Leu Asp Val Ser Val Leu Gly
                1045                1050                1055    
 Glu Leu Val Pro Arg Leu Cys Glu Leu Ile Arg Ser Gly Val Gly Leu
            1060                1065                1070        
 Gly Thr Lys Gly Gly Cys Ala Ser Val Ile Val Ser Leu Thr Thr Gln
        1075                1080                1085            
 Cys Pro Gln Asp Leu Thr Pro Tyr Ser Gly Lys Leu Met Ser Ala Leu
    1090                1095                1100                
 Leu Ser Gly Leu Thr Asp Arg Asn Ser Val Ile Gln Lys Ser Cys Ala
1105                1110                1115                1120
 Phe Ala Met Gly His Leu Val Arg Thr Ser Arg Asp Ser Ser Thr Glu
                1125                1130                1135    
 Lys Leu Leu Gln Lys Leu Asn Gly Trp Tyr Met Glu Lys Glu Glu Pro
            1140                1145                1150        
 Ile Tyr Lys Thr Ser Cys Ala Leu Thr Ile His Ala Ile Gly Arg Tyr
        1155                1160                1165            
 Ser Pro Asp Val Leu Lys Asn His Ala Lys Glu Val Leu Pro Leu Ala
    1170                1175                1180                
 Phe Leu Gly Met His Glu Ile Ala Asp Glu Glu Lys Ser Glu Lys Glu
1185                1190                1195                1200
 Glu Cys Asn Leu Trp Thr Glu Val Trp Gln Glu Asn Val Pro Gly Ser
                1205                1210                1215    
 Phe Gly Gly Ile Arg Leu Tyr Leu Gln Glu Leu Ile Thr Ile Thr Gln
            1220                1225                1230        
 Lys Ala Leu Gln Ser Gln Ser Trp Lys Met Lys Ala Gln Gly Ala Ile
        1235                1240                1245            
 Ala Met Ala Ser Ile Ala Lys Gln Thr Ser Ser Leu Val Pro Pro Tyr
    1250                1255                1260                
 Leu Gly Met Ile Leu Thr Ala Leu Leu Gln Gly Leu Ala Gly Arg Thr
1265                1270                1275                1280
 Trp Ala Gly Lys Glu Glu Leu Leu Lys Ala Ile Ala Cys Val Val Thr
                1285                1290                1295    
 Ala Cys Ser Ala Glu Leu Glu Lys Ser Val Pro Asn Gln Pro Ser Thr
            1300                1305                1310        
 Asn Glu Ile Leu Gln Ala Val Leu Lys Glu Cys Ser Lys Glu Asn Val
        1315                1320                1325            
 Lys Tyr Lys Ile Val Ala Ile Ser Cys Ala Ala Asp Ile Leu Lys Ala
    1330                1335                1340                
 Thr Lys Glu Asp Arg Phe Gln Glu Phe Ser Asn Ile Val Ile Pro Leu
1345                1350                1355                1360
 Ile Lys Lys Asn Ser Leu Glu Ser Ser Gly Val Arg Thr Thr Lys Asn
                1365                1370                1375    
 Glu Glu Glu Asn Glu Lys Glu Lys Glu Leu Gln Leu Glu Tyr Leu Leu
            1380                1385                1390        
 Gly Ala Phe Glu Ser Leu Gly Lys Ala Trp Pro Arg Asn Ala Glu Thr
        1395                1400                1405            
 Gln Arg Cys Tyr Arg Gln Glu Leu Cys Lys Leu Met Cys Glu Arg Leu
    1410                1415                1420                
 Lys Leu Ser Thr Trp Lys Val Gln Leu Gly Val Leu Gln Ser Met Asn
1425                1430                1435                1440
 Ala Phe Phe Gln Gly Leu Met Leu Leu Glu Glu Glu His Ala Asp Pro
                1445                1450                1455    
 Glu Ala Leu Ala Glu Ile Leu Leu Glu Thr Cys Lys Ser Ile Thr Tyr
            1460                1465                1470        
 Ser Leu Glu Asn Lys Thr Tyr Ser Ser Val Arg Thr Glu Ala Leu Ser
        1475                1480                1485            
 Val Ile Glu Leu Leu Leu Lys Lys Leu Glu Glu Ser Lys Gln Trp Glu
    1490                1495                1500                
 Cys Leu Thr Ser Glu Cys Arg Val Leu Leu Ile Glu Ser Leu Ala Thr
1505                1510                1515                1520
 Met Glu Pro Asp Ser Arg Pro Glu Leu Gln Glu Lys Ala Ala Leu Leu
                1525                1530                1535    
 Lys Lys Thr Leu Glu Asn Leu Glu
            1540                



      <210> 227
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 227
 Met Arg Glu Gly Ala Cys Lys Leu Leu Ala Ala Cys Ser Gln Arg Glu
   1               5                  10                  15    
 Gln Ala Leu Glu Ala Thr Lys Ser Leu Leu Val Cys Asn Ser Arg Ile
              20                  25                  30        
 Leu Ser Tyr Met Gly Glu Leu Gln Arg Arg Lys Glu Ala Gln Val Leu
          35                  40                  45            
 Gly Lys Thr Ser Arg Arg Pro Ser Asp Ser Gly Pro Pro Ala Glu Arg
      50                  55                  60                
 Ser Pro Cys Arg Gly Arg Val Cys Ile Ser Asp Leu Arg Ile Pro Leu
  65                  70                  75                  80
 Met Trp Lys Asp Thr Glu Tyr Phe Lys Asn Lys Gly Asp Leu His Arg
                  85                  90                  95    
 Trp Ala Val Phe Leu Leu Leu Gln Leu Gly Glu His Ile Gln Asp Thr
             100                 105                 110        
 Glu Met Ile Leu Val Asp Arg Thr Leu Thr Asp Ile Ser Phe Gln Ser
         115                 120                 125            
 Asn Val Leu Phe Ala Glu Ala Gly Pro Asp Phe Glu Leu Arg Leu Glu
     130                 135                 140                
 Leu Tyr Gly Ala Cys Val Glu Glu Glu Gly Ala Leu Thr Gly Gly Pro
 145                 150                 155                 160
 Lys Arg Leu Ala Thr Lys Leu Ser Ser Ser Leu Gly Arg Ser Ser Gly
                 165                 170                 175    
 Arg Arg Val Arg Ala Ser Leu Asp Ser Ala Gly Gly Ser Gly Ser Ser
             180                 185                 190        
 Pro Ile Leu Leu Pro Thr Pro Val Val Gly Gly Pro Arg Tyr His Leu
         195                 200                 205            
 Leu Ala His Thr Thr Leu Thr Leu Ala Ala Val Gln Asp Gly Phe Arg
     210                 215                 220                
 Thr His Asp Leu Thr Leu Ala Ser His Glu Glu Asn Pro Ala Trp Leu
 225                 230                 235                 240
 Pro Leu Tyr Gly Ser Val Cys Cys Arg Leu Ala Ala Gln Pro Leu Cys
                 245                 250                 255    
 Met Thr Gln Pro Thr Ala Ser Gly Thr Leu Arg Val Gln Gln Ala Gly
             260                 265                 270        
 Glu Met Gln Asn Trp Ala Gln Val His Gly Val Leu Lys Gly Thr Asn
         275                 280                 285            
 Leu Phe Cys Tyr Arg Gln Pro Glu Asp Ala Asp Thr Gly Glu Glu Pro
     290                 295                 300                
 Leu Leu Thr Ile Ala Val Asn Lys Glu Thr Arg Val Arg Ala Gly Glu
 305                 310                 315                 320
 Leu Asp Gln Ala Leu Gly Arg Pro Phe Thr Leu Ser Ile Ser Asn Gln
                 325                 330                 335    
 Tyr Gly Asp Asp Glu Val Thr His Thr Leu Gln Thr Glu Ser Arg Glu
             340                 345                 350        
 Ala Leu Gln Ser Trp Met Glu Ala Leu Trp Gln Leu Phe Phe Asp Met
         355                 360                 365            
 Ser Gln Trp Lys Gln Cys Cys Asp Glu Ile Met Lys Ile Glu Thr Pro
     370                 375                 380                
 Ala Pro Arg Lys Pro Pro Gln Ala Leu Ala Lys Gln Gly Ser Leu Tyr
 385                 390                 395                 400
 His Glu Met Ala Ile Glu Pro Leu Asp Asp Ile Ala Ala Val Thr Asp
                 405                 410                 415    
 Ile Leu Thr Gln Arg Glu Gly Ala Arg Leu Glu Thr Pro Pro Pro Trp
             420                 425                 430        
 Leu Ala Met Phe Thr Asp Gln Pro Ala Leu Pro Asn Pro Cys Ser Pro
         435                 440                 445            
 Ala Ser Val Ala Pro Ala Pro Asp Trp Thr His Pro Leu Pro Trp Gly
     450                 455                 460                
 Arg Pro Arg Thr Phe Ser Leu Asp Ala Val Pro Pro Asp His Ser Pro
 465                 470                 475                 480
 Arg Ala Arg Ser Val Ala Pro Leu Pro Pro Gln Arg Ser Pro Arg Thr
                 485                 490                 495    
 Arg Gly Leu Cys Ser Lys Gly Gln Pro Arg Thr Trp Leu Gln Ser Pro
             500                 505                 510        
 Val
    



      <210> 228
      <211> 365
      <212> PRT
      <213> Homo sapiens


      <400> 228
 Met Thr Glu Lys Glu Val Leu Glu Ser Pro Lys Pro Ser Phe Pro Ala
   1               5                  10                  15    
 Glu Thr Arg Gln Ser Gly Leu Gln Arg Leu Lys Gln Leu Leu Arg Lys
              20                  25                  30        
 Gly Ser Thr Gly Thr Lys Glu Met Glu Leu Pro Pro Glu Pro Gln Ala
          35                  40                  45            
 Asn Gly Glu Ala Val Gly Ala Gly Gly Gly Pro Ile Tyr Tyr Ile Tyr
      50                  55                  60                
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro Pro Pro Glu
  65                  70                  75                  80
 Pro Pro Lys Leu Val Asn Asp Lys Pro His Lys Phe Lys Asp His Phe
                  85                  90                  95    
 Phe Lys Lys Pro Lys Phe Cys Asp Val Cys Ala Arg Met Ile Val Leu
             100                 105                 110        
 Asn Asn Lys Phe Gly Leu Arg Cys Lys Asn Cys Lys Thr Asn Ile His
         115                 120                 125            
 Glu His Cys Gln Ser Tyr Val Glu Met Gln Arg Cys Phe Gly Lys Ile
     130                 135                 140                
 Pro Pro Gly Phe His Arg Ala Tyr Ser Ser Pro Leu Tyr Ser Asn Gln
 145                 150                 155                 160
 Gln Tyr Ala Cys Val Lys Asp Leu Ser Ala Ala Asn Arg Asn Asp Pro
                 165                 170                 175    
 Val Phe Glu Thr Leu Arg Thr Gly Val Ile Met Ala Asn Lys Glu Arg
             180                 185                 190        
 Lys Lys Gly Gln Ala Asp Lys Lys Asn Pro Val Ala Ala Met Met Glu
         195                 200                 205            
 Glu Glu Pro Glu Ser Ala Arg Pro Glu Glu Gly Lys Pro Gln Asp Gly
     210                 215                 220                
 Asn Pro Glu Gly Asp Lys Lys Ala Glu Lys Lys Thr Pro Asp Asp Lys
 225                 230                 235                 240
 His Lys Gln Pro Gly Phe Gln Gln Ser His Tyr Phe Val Ala Leu Tyr
                 245                 250                 255    
 Arg Phe Lys Ala Leu Glu Lys Asp Asp Leu Asp Phe Pro Pro Gly Glu
             260                 265                 270        
 Lys Ile Thr Val Ile Asp Asp Ser Asn Glu Glu Trp Trp Arg Gly Lys
         275                 280                 285            
 Ile Gly Glu Lys Val Gly Phe Phe Pro Pro Asn Phe Ile Ile Arg Val
     290                 295                 300                
 Arg Ala Gly Glu Arg Val His Arg Val Thr Arg Ser Phe Val Gly Asn
 305                 310                 315                 320
 Arg Glu Ile Gly Gln Ile Thr Leu Lys Lys Asp Gln Ile Val Val Gln
                 325                 330                 335    
 Lys Gly Asp Glu Ala Gly Gly Tyr Val Lys Val Tyr Thr Gly Arg Lys
             340                 345                 350        
 Val Gly Leu Phe Pro Thr Asp Phe Leu Glu Glu Ile
         355                 360                



      <210> 229
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 229
 Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly
   1               5                  10                  15    
 Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg
              20                  25                  30        
 Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp
          35                  40                  45            
 Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala
      50                  55                  60                
 Asp Ala Leu Thr Asn Ala Val Ala Asn Val Gly Arg His Ala Gln Arg
  65                  70                  75                  80
 Ala Val Arg Pro Glu Arg Pro Ala Arg Ala Gln Ala Ser Gly Gly Pro
                  85                  90                  95    
 Gly Gln Leu Gln Ala Pro Lys Pro Leu Pro Ala Gly Asp Pro Gly Pro
             100                 105                 110        
 Pro Thr Ser Pro Pro Ser Ser Pro Pro Ala Val Ala Thr Phe Ser Leu
         115                 120                 125            
 Gly Thr Ser Ser Trp Phe Phe Val Glu His Arg Val Asp Cys Lys Tyr
     130                 135                 140                
 Leu
 145



      <210> 230
      <211> 1248
      <212> PRT
      <213> Homo sapiens


      <400> 230
 Met Glu Asp Ala Gly Ala Ala Gly Pro Gly Pro Glu Pro Glu Pro Glu
   1               5                  10                  15    
 Pro Glu Pro Glu Pro Glu Pro Ala Pro Glu Pro Glu Pro Glu Pro Lys
              20                  25                  30        
 Pro Gly Ala Gly Thr Ser Glu Ala Phe Ser Arg Leu Trp Thr Asp Val
          35                  40                  45            
 Met Gly Ile Leu Asp Gly Ser Leu Gly Asn Ile Asp Asp Leu Ala Gln
      50                  55                  60                
 Gln Tyr Ala Asp Tyr Tyr Asn Thr Cys Phe Ser Asp Val Cys Glu Arg
  65                  70                  75                  80
 Met Glu Glu Leu Arg Lys Arg Arg Val Ser Gln Asp Leu Glu Val Glu
                  85                  90                  95    
 Lys Pro Asp Ala Ser Pro Thr Ser Leu Gln Leu Arg Ser Gln Ile Glu
             100                 105                 110        
 Glu Ser Leu Gly Phe Cys Ser Ala Val Ser Thr Pro Glu Val Glu Arg
         115                 120                 125            
 Lys Asn Pro Leu His Lys Ser Asn Ser Glu Asp Ser Ser Val Gly Lys
     130                 135                 140                
 Gly Asp Trp Lys Lys Lys Asn Lys Tyr Phe Trp Gln Asn Phe Arg Lys
 145                 150                 155                 160
 Asn Gln Lys Gly Ile Met Arg Gln Thr Ser Lys Gly Glu Asp Val Gly
                 165                 170                 175    
 Tyr Val Ala Ser Glu Ile Thr Met Ser Asp Glu Glu Arg Ile Gln Leu
             180                 185                 190        
 Met Met Met Val Lys Glu Lys Met Ile Thr Ile Glu Glu Ala Leu Ala
         195                 200                 205            
 Arg Leu Lys Glu Tyr Glu Ala Gln His Arg Gln Ser Ala Ala Leu Asp
     210                 215                 220                
 Pro Ala Asp Trp Pro Asp Gly Ser Tyr Pro Thr Phe Asp Gly Ser Ser
 225                 230                 235                 240
 Asn Cys Asn Ser Arg Glu Gln Ser Asp Asp Glu Thr Glu Glu Ser Val
                 245                 250                 255    
 Lys Phe Lys Arg Leu His Lys Leu Val Asn Ser Thr Arg Arg Val Arg
             260                 265                 270        
 Lys Lys Leu Ile Arg Val Glu Glu Met Lys Lys Pro Ser Thr Glu Gly
         275                 280                 285            
 Gly Glu Glu His Val Phe Glu Asn Ser Pro Val Leu Asp Glu Arg Ser
     290                 295                 300                
 Ala Leu Tyr Ser Gly Val His Lys Lys Pro Leu Phe Phe Asp Gly Ser
 305                 310                 315                 320
 Pro Glu Lys Pro Pro Glu Asp Asp Ser Asp Ser Leu Thr Thr Ser Pro
                 325                 330                 335    
 Ser Ser Ser Ser Leu Asp Thr Trp Gly Ala Gly Arg Lys Leu Val Lys
             340                 345                 350        
 Thr Phe Ser Lys Gly Glu Ser Arg Gly Leu Ile Lys Pro Pro Lys Lys
         355                 360                 365            
 Met Gly Thr Phe Phe Ser Tyr Pro Glu Glu Glu Lys Ala Gln Lys Val
     370                 375                 380                
 Ser Arg Ser Leu Thr Glu Gly Glu Met Lys Lys Gly Leu Gly Ser Leu
 385                 390                 395                 400
 Ser His Gly Arg Thr Cys Ser Phe Gly Gly Phe Asp Leu Thr Asn Arg
                 405                 410                 415    
 Ser Leu His Val Gly Ser Asn Asn Ser Asp Pro Met Gly Lys Glu Gly
             420                 425                 430        
 Asp Phe Val Tyr Lys Glu Val Ile Lys Ser Pro Thr Ala Ser Arg Ile
         435                 440                 445            
 Ser Leu Gly Lys Lys Val Lys Ser Val Lys Glu Thr Met Arg Lys Arg
     450                 455                 460                
 Met Ser Lys Lys Tyr Ser Ser Ser Val Ser Glu Gln Asp Ser Gly Leu
 465                 470                 475                 480
 Asp Gly Met Pro Gly Ser Pro Pro Pro Ser Gln Pro Asp Pro Glu His
                 485                 490                 495    
 Leu Asp Lys Pro Lys Leu Lys Ala Gly Gly Ser Val Glu Ser Leu Arg
             500                 505                 510        
 Ser Ser Leu Ser Gly Gln Ser Ser Met Ser Gly Gln Thr Val Ser Thr
         515                 520                 525            
 Thr Asp Ser Ser Thr Ser Asn Arg Glu Ser Val Lys Ser Glu Asp Gly
     530                 535                 540                
 Asp Asp Glu Glu Pro Pro Tyr Arg Gly Pro Phe Cys Gly Arg Ala Arg
 545                 550                 555                 560
 Val His Thr Asp Phe Thr Pro Ser Pro Tyr Asp Thr Asp Ser Leu Lys
                 565                 570                 575    
 Leu Lys Lys Gly Asp Ile Ile Asp Ile Ile Ser Lys Pro Pro Met Gly
             580                 585                 590        
 Thr Trp Met Gly Leu Leu Asn Asn Lys Val Gly Thr Phe Lys Phe Ile
         595                 600                 605            
 Tyr Val Asp Val Leu Ser Glu Asp Glu Glu Lys Pro Lys Arg Pro Thr
     610                 615                 620                
 Arg Arg Arg Arg Lys Gly Arg Pro Pro Gln Pro Lys Ser Val Glu Asp
 625                 630                 635                 640
 Leu Leu Asp Arg Ile Asn Leu Lys Glu His Met Pro Thr Phe Leu Phe
                 645                 650                 655    
 Asn Gly Tyr Glu Asp Leu Asp Thr Phe Lys Leu Leu Glu Glu Glu Asp
             660                 665                 670        
 Leu Asp Glu Leu Asn Ile Arg Asp Pro Glu His Arg Ala Val Leu Leu
         675                 680                 685            
 Thr Ala Val Glu Leu Leu Gln Glu Tyr Asp Ser Asn Ser Asp Gln Ser
     690                 695                 700                
 Gly Ser Gln Glu Lys Leu Leu Val Asp Ser Gln Gly Leu Ser Gly Cys
 705                 710                 715                 720
 Ser Pro Arg Asp Ser Gly Cys Tyr Glu Ser Ser Glu Asn Leu Glu Asn
                 725                 730                 735    
 Gly Lys Thr Arg Lys Ala Ser Leu Leu Ser Ala Lys Ser Ser Thr Glu
             740                 745                 750        
 Pro Ser Leu Lys Ser Phe Ser Arg Asn Gln Leu Gly Asn Tyr Pro Thr
         755                 760                 765            
 Leu Pro Leu Met Lys Ser Gly Asp Ala Leu Lys Gln Gly Gln Glu Glu
     770                 775                 780                
 Gly Arg Leu Gly Gly Gly Leu Ala Pro Asp Thr Ser Lys Ser Cys Asp
 785                 790                 795                 800
 Pro Pro Gly Val Thr Gly Leu Asn Lys Asn Arg Arg Ser Leu Pro Val
                 805                 810                 815    
 Ser Ile Cys Arg Ser Cys Glu Thr Leu Glu Gly Pro Gln Thr Val Asp
             820                 825                 830        
 Thr Trp Pro Arg Ser His Ser Leu Asp Asp Leu Gln Val Glu Pro Gly
         835                 840                 845            
 Ala Glu Gln Asp Val Pro Thr Glu Val Thr Glu Pro Pro Pro Gln Ile
     850                 855                 860                
 Val Pro Glu Val Pro Gln Lys Thr Thr Ala Ser Ser Thr Lys Ala Gln
 865                 870                 875                 880
 Pro Leu Glu Gln Asp Ser Ala Val Asp Asn Ala Leu Leu Leu Thr Gln
                 885                 890                 895    
 Ser Lys Arg Phe Ser Glu Pro Gln Lys Leu Thr Thr Lys Lys Leu Glu
             900                 905                 910        
 Gly Ser Ile Ala Ala Ser Gly Arg Gly Leu Ser Pro Pro Gln Cys Leu
         915                 920                 925            
 Pro Arg Asn Tyr Asp Ala Gln Pro Pro Gly Ala Lys His Gly Leu Ala
     930                 935                 940                
 Arg Thr Pro Leu Glu Gly His Arg Lys Gly His Glu Phe Glu Gly Thr
 945                 950                 955                 960
 His His Pro Leu Gly Thr Lys Glu Gly Val Asp Ala Glu Gln Arg Met
                 965                 970                 975    
 Gln Pro Lys Ile Pro Ser Gln Pro Pro Pro Val Pro Ala Lys Lys Ser
             980                 985                 990        
 Arg Glu Arg Leu Ala Asn Gly Leu His Pro Val Pro Met Gly Pro Ser
         995                1000                1005            
 Gly Ala Leu Pro Ser Pro Asp Ala Pro Cys Leu Pro Val Lys Arg Gly
    1010                1015                1020                
 Ser Pro Ala Ser Pro Thr Ser Pro Ser Asp Cys Pro Pro Ala Leu Ala
1025                1030                1035                1040
 Pro Arg Pro Leu Ser Gly Gln Ala Pro Gly Ser Pro Pro Ser Thr Arg
                1045                1050                1055    
 Pro Pro Pro Trp Leu Ser Glu Leu Pro Glu Asn Thr Ser Leu Gln Glu
            1060                1065                1070        
 His Gly Val Lys Leu Gly Pro Ala Leu Thr Arg Lys Val Ser Cys Ala
        1075                1080                1085            
 Arg Gly Val Asp Leu Glu Thr Leu Thr Glu Asn Lys Leu His Ala Glu
    1090                1095                1100                
 Gly Ile Asp Leu Thr Glu Glu Pro Tyr Ser Asp Lys His Gly Arg Cys
1105                1110                1115                1120
 Gly Ile Pro Glu Ala Leu Val Gln Arg Tyr Ala Glu Asp Leu Asp Gln
                1125                1130                1135    
 Pro Glu Arg Asp Val Ala Ala Asn Met Asp Gln Ile Arg Val Lys Gln
            1140                1145                1150        
 Leu Arg Lys Gln His Arg Met Ala Ile Pro Ser Gly Gly Leu Thr Glu
        1155                1160                1165            
 Ile Cys Arg Lys Pro Val Ser Pro Gly Cys Ile Ser Ser Val Ser Asp
    1170                1175                1180                
 Trp Leu Ile Ser Ile Gly Leu Pro Met Tyr Ala Gly Thr Leu Ser Thr
1185                1190                1195                1200
 Ala Gly Phe Ser Thr Leu Ser Gln Val Pro Ser Leu Ser His Thr Cys
                1205                1210                1215    
 Leu Gln Glu Ala Gly Ile Thr Glu Glu Arg His Ile Arg Lys Leu Leu
            1220                1225                1230        
 Ser Ala Ala Arg Leu Phe Lys Leu Pro Pro Gly Pro Glu Ala Met
        1235                1240                1245        



      <210> 231
      <211> 856
      <212> PRT
      <213> Homo sapiens


      <400> 231
 Met Val Val Met Ala Arg Leu Ser Arg Pro Glu Arg Pro Asp Leu Val
   1               5                  10                  15    
 Phe Glu Glu Glu Asp Leu Pro Tyr Glu Glu Glu Ile Met Arg Asn Gln
              20                  25                  30        
 Phe Ser Val Lys Cys Trp Leu Arg Tyr Ile Glu Phe Lys Gln Gly Ala
          35                  40                  45            
 Pro Lys Pro Arg Leu Asn Gln Leu Tyr Glu Arg Ala Leu Lys Leu Leu
      50                  55                  60                
 Pro Cys Ser Tyr Lys Leu Trp Tyr Arg Tyr Leu Lys Ala Arg Arg Ala
  65                  70                  75                  80
 Gln Val Lys His Arg Cys Val Thr Asp Pro Ala Tyr Glu Asp Val Asn
                  85                  90                  95    
 Asn Cys His Glu Arg Ala Phe Val Phe Met His Lys Met Pro Arg Leu
             100                 105                 110        
 Trp Leu Asp Tyr Cys Gln Phe Leu Met Asp Gln Gly Arg Val Thr His
         115                 120                 125            
 Thr Arg Arg Thr Phe Asp Arg Ala Leu Arg Ala Leu Pro Ile Thr Gln
     130                 135                 140                
 His Ser Arg Ile Trp Pro Leu Tyr Leu Arg Phe Leu Arg Ser His Pro
 145                 150                 155                 160
 Leu Pro Glu Thr Ala Val Arg Gly Tyr Arg Arg Phe Leu Lys Leu Ser
                 165                 170                 175    
 Pro Glu Ser Ala Glu Glu Tyr Ile Glu Tyr Leu Lys Ser Ser Asp Arg
             180                 185                 190        
 Leu Asp Glu Ala Ala Gln Arg Leu Ala Thr Val Val Asn Asp Glu Arg
         195                 200                 205            
 Phe Val Ser Lys Ala Gly Lys Ser Asn Tyr Gln Leu Trp His Glu Leu
     210                 215                 220                
 Cys Asp Leu Ile Ser Gln Asn Pro Asp Lys Val Gln Ser Leu Asn Val
 225                 230                 235                 240
 Asp Ala Ile Ile Arg Gly Gly Leu Thr Arg Phe Thr Asp Gln Leu Gly
                 245                 250                 255    
 Lys Leu Trp Cys Ser Leu Ala Asp Tyr Tyr Ile Arg Ser Gly His Phe
             260                 265                 270        
 Glu Lys Ala Arg Asp Val Tyr Glu Glu Ala Ile Arg Thr Val Met Thr
         275                 280                 285            
 Val Arg Asp Phe Thr Gln Val Phe Asp Ser Tyr Ala Gln Phe Glu Glu
     290                 295                 300                
 Ser Met Ile Ala Ala Lys Met Glu Thr Ala Ser Glu Leu Gly Arg Glu
 305                 310                 315                 320
 Glu Glu Asp Asp Val Asp Leu Glu Leu Arg Leu Ala Arg Phe Glu Gln
                 325                 330                 335    
 Leu Ile Ser Arg Arg Pro Leu Leu Leu Asn Ser Val Leu Leu Arg Gln
             340                 345                 350        
 Asn Pro His His Val His Glu Trp His Lys Arg Val Ala Leu His Gln
         355                 360                 365            
 Gly Arg Pro Arg Glu Ile Ile Asn Thr Tyr Thr Glu Ala Val Gln Thr
     370                 375                 380                
 Val Asp Pro Phe Lys Ala Thr Gly Lys Pro His Thr Leu Trp Val Ala
 385                 390                 395                 400
 Phe Ala Lys Phe Tyr Glu Asp Asn Gly Gln Leu Asp Asp Ala Arg Val
                 405                 410                 415    
 Ile Leu Glu Lys Ala Thr Lys Val Asn Phe Lys Gln Val Asp Asp Leu
             420                 425                 430        
 Ala Ser Val Trp Cys Gln Cys Gly Glu Leu Glu Leu Arg His Glu Asn
         435                 440                 445            
 Tyr Asp Glu Ala Leu Arg Leu Leu Arg Lys Ala Thr Ala Leu Pro Ala
     450                 455                 460                
 Arg Arg Ala Glu Tyr Phe Asp Gly Ser Glu Pro Val Gln Asn Arg Val
 465                 470                 475                 480
 Tyr Lys Ser Leu Lys Val Trp Ser Met Leu Ala Asp Leu Glu Glu Ser
                 485                 490                 495    
 Leu Gly Thr Phe Gln Ser Thr Lys Ala Val Tyr Asp Arg Ile Leu Asp
             500                 505                 510        
 Leu Arg Ile Ala Thr Pro Gln Ile Val Ile Asn Tyr Ala Met Phe Leu
         515                 520                 525            
 Glu Glu His Lys Tyr Phe Glu Glu Ser Phe Lys Ala Tyr Glu Arg Gly
     530                 535                 540                
 Ile Ser Leu Phe Lys Trp Pro Asn Val Ser Asp Ile Trp Ser Thr Tyr
 545                 550                 555                 560
 Leu Thr Lys Phe Ile Ala Arg Tyr Gly Gly Arg Lys Leu Glu Arg Ala
                 565                 570                 575    
 Arg Asp Leu Phe Glu Gln Ala Leu Asp Gly Cys Pro Pro Lys Tyr Ala
             580                 585                 590        
 Lys Thr Leu Tyr Leu Leu Tyr Ala Gln Leu Glu Glu Glu Trp Gly Leu
         595                 600                 605            
 Ala Arg His Ala Met Ala Val Tyr Glu Arg Ala Thr Arg Ala Val Glu
     610                 615                 620                
 Pro Ala Gln Gln Tyr Asp Met Phe Asn Ile Tyr Ile Lys Arg Ala Ala
 625                 630                 635                 640
 Glu Ile Tyr Gly Val Thr His Thr Arg Gly Ile Tyr Gln Lys Ala Ile
                 645                 650                 655    
 Glu Val Leu Ser Asp Glu His Ala Arg Glu Met Cys Leu Arg Phe Ala
             660                 665                 670        
 Asp Met Glu Cys Lys Leu Gly Glu Ile Asp Arg Ala Arg Ala Ile Tyr
         675                 680                 685            
 Ser Phe Cys Ser Gln Ile Cys Asp Pro Arg Thr Thr Gly Ala Phe Trp
     690                 695                 700                
 Gln Thr Trp Lys Asp Phe Glu Val Arg His Gly Asn Glu Asp Thr Ile
 705                 710                 715                 720
 Lys Glu Met Leu Arg Ile Arg Arg Ser Val Gln Ala Thr Tyr Asn Thr
                 725                 730                 735    
 Gln Val Asn Phe Met Ala Ser Gln Met Leu Lys Val Ser Gly Ser Ala
             740                 745                 750        
 Thr Gly Thr Val Ser Asp Leu Ala Pro Gly Gln Ser Gly Met Asp Asp
         755                 760                 765            
 Met Lys Leu Leu Glu Gln Arg Ala Glu Gln Leu Ala Ala Glu Ala Glu
     770                 775                 780                
 Arg Asp Gln Pro Leu Arg Ala Gln Ser Lys Ile Leu Phe Val Arg Ser
 785                 790                 795                 800
 Asp Ala Ser Arg Glu Glu Leu Ala Glu Leu Ala Gln Gln Val Asn Pro
                 805                 810                 815    
 Glu Glu Ile Gln Leu Gly Glu Asp Glu Asp Glu Asp Glu Met Asp Leu
             820                 825                 830        
 Glu Pro Asn Glu Val Arg Leu Glu Gln Gln Ser Val Pro Ala Ala Val
         835                 840                 845            
 Phe Gly Ser Leu Lys Glu Asp
     850                 855



      <210> 232
      <211> 772
      <212> PRT
      <213> Homo sapiens


      <400> 232
 Met His Arg Ser Gly Arg Tyr Gly Thr Gln Gln Gln Arg Ala Gly Ser
   1               5                  10                  15    
 Lys Thr Ala Gly Pro Pro Cys Gln Trp Ser Arg Met Ala Ser Glu Gly
              20                  25                  30        
 Thr Asn Ile Pro Ser Pro Val Val Arg Gln Ile Asp Lys Gln Phe Leu
          35                  40                  45            
 Ile Cys Ser Ile Cys Leu Glu Arg Tyr Lys Asn Pro Lys Val Leu Pro
      50                  55                  60                
 Cys Leu His Thr Phe Cys Glu Arg Cys Leu Gln Asn Tyr Ile Pro Ala
  65                  70                  75                  80
 His Ser Leu Thr Leu Ser Cys Pro Val Cys Arg Gln Thr Ser Ile Leu
                  85                  90                  95    
 Pro Glu Lys Gly Val Ala Ala Leu Gln Asn Asn Phe Phe Ile Thr Asn
             100                 105                 110        
 Leu Met Asp Val Leu Gln Arg Thr Pro Gly Ser Asn Ala Glu Glu Ser
         115                 120                 125            
 Ser Ile Leu Glu Thr Val Thr Ala Val Ala Ala Gly Lys Pro Leu Ser
     130                 135                 140                
 Cys Pro Asn His Asp Gly Asn Val Met Glu Phe Tyr Cys Gln Ser Cys
 145                 150                 155                 160
 Glu Thr Ala Met Cys Arg Glu Cys Thr Glu Gly Glu His Ala Glu His
                 165                 170                 175    
 Pro Thr Val Pro Leu Lys Asp Val Val Glu Gln His Lys Ala Ser Leu
             180                 185                 190        
 Gln Val Gln Leu Asp Ala Val Asn Lys Arg Leu Pro Glu Ile Asp Ser
         195                 200                 205            
 Ala Leu Gln Phe Ile Ser Glu Ile Ile His Gln Leu Thr Asn Gln Lys
     210                 215                 220                
 Ala Ser Ile Val Asp Asp Ile His Ser Thr Phe Asp Glu Leu Gln Lys
 225                 230                 235                 240
 Thr Leu Asn Val Arg Lys Ser Val Leu Leu Met Glu Leu Glu Val Asn
                 245                 250                 255    
 Tyr Gly Leu Lys His Lys Val Leu Gln Ser Gln Leu Asp Thr Leu Leu
             260                 265                 270        
 Gln Gly Gln Glu Ser Ile Lys Ser Cys Ser Asn Phe Thr Ala Gln Ala
         275                 280                 285            
 Leu Asn His Gly Thr Glu Thr Glu Val Leu Leu Val Lys Lys Gln Met
     290                 295                 300                
 Ser Glu Lys Leu Asn Glu Leu Ala Asp Gln Asp Phe Pro Leu His Pro
 305                 310                 315                 320
 Arg Glu Asn Asp Gln Leu Asp Phe Ile Val Glu Thr Glu Gly Leu Lys
                 325                 330                 335    
 Lys Ser Ile His Asn Leu Gly Thr Ile Leu Thr Thr Asn Ala Val Ala
             340                 345                 350        
 Ser Glu Thr Val Ala Thr Gly Glu Gly Leu Arg Gln Thr Ile Ile Gly
         355                 360                 365            
 Gln Pro Met Ser Val Thr Ile Thr Thr Lys Asp Lys Asp Gly Glu Leu
     370                 375                 380                
 Cys Lys Thr Gly Asn Ala Tyr Leu Thr Ala Glu Leu Ser Thr Pro Asp
 385                 390                 395                 400
 Gly Ser Val Ala Asp Gly Glu Ile Leu Asp Asn Lys Asn Gly Thr Tyr
                 405                 410                 415    
 Glu Phe Leu Tyr Thr Val Gln Lys Glu Gly Asp Phe Thr Leu Ser Leu
             420                 425                 430        
 Arg Leu Tyr Asp Gln His Ile Arg Gly Ser Pro Phe Lys Leu Lys Val
         435                 440                 445            
 Ile Arg Ser Ala Asp Val Ser Pro Thr Thr Glu Gly Val Lys Arg Arg
     450                 455                 460                
 Val Lys Ser Pro Gly Ser Gly His Val Lys Gln Lys Ala Val Lys Arg
 465                 470                 475                 480
 Pro Ala Ser Met Tyr Ser Thr Gly Lys Arg Lys Glu Asn Pro Ile Glu
                 485                 490                 495    
 Asp Asp Leu Ile Phe Arg Val Gly Thr Lys Gly Arg Asn Lys Gly Glu
             500                 505                 510        
 Phe Thr Asn Leu Gln Gly Val Ala Ala Ser Thr Asn Gly Lys Ile Leu
         515                 520                 525            
 Ile Ala Asp Ser Asn Asn Gln Cys Val Gln Ile Phe Ser Asn Asp Gly
     530                 535                 540                
 Gln Phe Lys Ser Arg Phe Gly Ile Arg Gly Arg Ser Pro Gly Gln Leu
 545                 550                 555                 560
 Gln Arg Pro Thr Gly Val Ala Val His Pro Ser Gly Asp Ile Ile Ile
                 565                 570                 575    
 Ala Asp Tyr Asp Asn Lys Trp Val Ser Ile Phe Ser Ser Asp Gly Lys
             580                 585                 590        
 Phe Lys Thr Lys Ile Gly Ser Gly Lys Leu Met Gly Pro Lys Gly Val
         595                 600                 605            
 Ser Val Asp Arg Asn Gly His Ile Ile Val Val Asp Asn Lys Ala Cys
     610                 615                 620                
 Cys Val Phe Ile Phe Gln Pro Asn Gly Lys Ile Val Thr Arg Phe Gly
 625                 630                 635                 640
 Ser Arg Gly Asn Gly Asp Arg Gln Phe Ala Gly Pro His Phe Ala Ala
                 645                 650                 655    
 Val Asn Ser Asn Asn Glu Ile Ile Ile Thr Asp Phe His Asn His Ser
             660                 665                 670        
 Val Lys Val Phe Asn Gln Glu Gly Glu Phe Met Leu Lys Phe Gly Ser
         675                 680                 685            
 Asn Gly Glu Gly Asn Gly Gln Phe Asn Ala Pro Thr Gly Val Ala Val
     690                 695                 700                
 Asp Ser Asn Gly Asn Ile Ile Val Ala Asp Trp Gly Asn Ser Arg Ile
 705                 710                 715                 720
 Gln Val Phe Asp Gly Ser Gly Ser Phe Leu Ser Tyr Ile Asn Thr Ser
                 725                 730                 735    
 Ala Asp Pro Leu Tyr Gly Pro Gln Gly Leu Ala Leu Thr Ser Asp Gly
             740                 745                 750        
 His Val Val Val Ala Asp Ser Gly Asn His Cys Phe Lys Val Tyr Arg
         755                 760                 765            
 Tyr Leu Gln
     770    



      <210> 233
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 233
 Met His Leu Ile Gly Ser Ala Thr Leu Ala Ile Ser Thr Ile Asn Leu
   1               5                  10                  15    
 Pro Ser Thr Leu Ile Ile Phe Thr Ile Leu Ile Leu Leu Thr Ile Leu
              20                  25                  30        
 Glu Ile Ala Val Ala Leu Ile Gln Ala Tyr Val Phe Thr Leu Leu Val
          35                  40                  45            
 Ser Leu Tyr Leu His Asp Asn Thr
      50                  55    



      <210> 234
      <211> 804
      <212> PRT
      <213> Homo sapiens


      <400> 234
 Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe
   1               5                  10                  15    
 Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu
              20                  25                  30        
 Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val
          35                  40                  45            
 Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser
      50                  55                  60                
 Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala
  65                  70                  75                  80
 Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn
                  85                  90                  95    
 Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu
             100                 105                 110        
 Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly
         115                 120                 125            
 Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu
     130                 135                 140                
 Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val
 145                 150                 155                 160
 Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn
                 165                 170                 175    
 Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile
             180                 185                 190        
 Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys
         195                 200                 205            
 Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu
     210                 215                 220                
 Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr
 225                 230                 235                 240
 Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser
                 245                 250                 255    
 Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser
             260                 265                 270        
 Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr
         275                 280                 285            
 Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu
     290                 295                 300                
 Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys
 305                 310                 315                 320
 Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met
                 325                 330                 335    
 Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu
             340                 345                 350        
 Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp
         355                 360                 365            
 Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys
     370                 375                 380                
 Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu
 385                 390                 395                 400
 Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val
                 405                 410                 415    
 Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe
             420                 425                 430        
 Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg
         435                 440                 445            
 Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu
     450                 455                 460                
 Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr
 465                 470                 475                 480
 Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val
                 485                 490                 495    
 Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe
             500                 505                 510        
 Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val
         515                 520                 525            
 Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser
     530                 535                 540                
 Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys
 545                 550                 555                 560
 Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys
                 565                 570                 575    
 Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala
             580                 585                 590        
 Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg
         595                 600                 605            
 Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp
     610                 615                 620                
 Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu
 625                 630                 635                 640
 Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly
                 645                 650                 655    
 Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp
             660                 665                 670        
 Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn
         675                 680                 685            
 Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp
     690                 695                 700                
 Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr
 705                 710                 715                 720
 Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly
                 725                 730                 735    
 Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp
             740                 745                 750        
 Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu
         755                 760                 765            
 Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val
     770                 775                 780                
 Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys
 785                 790                 795                 800
 Asp Glu Leu
            



      <210> 235
      <211> 83
      <212> PRT
      <213> Homo sapiens


      <400> 235
 Met Gly Arg Glu Phe Gly Asn Leu Thr Arg Met Arg His Val Ile Ser
   1               5                  10                  15    
 Tyr Ser Leu Ser Pro Phe Glu Gln Arg Ala Tyr Pro His Val Phe Thr
              20                  25                  30        
 Lys Gly Ile Pro Asn Val Leu Arg Arg Ile Arg Glu Ser Phe Phe Arg
          35                  40                  45            
 Val Val Pro Gln Phe Val Val Phe Tyr Leu Ile Tyr Thr Trp Gly Thr
      50                  55                  60                
 Glu Glu Phe Glu Arg Ser Lys Arg Lys Asn Pro Ala Ala Tyr Glu Asn
  65                  70                  75                  80
 Asp Lys
        



      <210> 236
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 236
 Met Thr Val Gln Trp Gly Val Gln Gln Ala Pro Ser Pro Phe Gln Ser
   1               5                  10                  15    
 Pro Leu His Ser Glu Thr Val Ile Ser His Ala Arg Gly Pro Asn Ile
              20                  25                  30        
 Leu Pro Asn Asp Asp Lys Asn His Thr Leu Gly Thr Thr Asn Cys Gly
          35                  40                  45            
 Gln Ala Trp Trp Leu Met Tyr Val Ile Pro Lys Ile Trp Glu Ala Lys
      50                  55                  60                
 Glu Gly Lys Ser Leu Glu Ala Arg Ser Ser Gly Pro Ala Trp Ala Thr
  65                  70                  75                  80
 Lys Gln Asp Pro Ile Ser Thr Ile Asn Gln
                  85                  90



      <210> 237
      <211> 288
      <212> PRT
      <213> Homo sapiens


      <400> 237
 Met Gly Thr Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr
   1               5                  10                  15    
 Ser Asp Glu Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly
              20                  25                  30        
 Lys Glu Leu Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu
          35                  40                  45            
 Lys Thr Ala Leu Ala Leu Leu Asp His Pro Ser Glu Tyr Ala Ala Arg
      50                  55                  60                
 Gln Leu Gln Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu
  65                  70                  75                  80
 Ile Glu Phe Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys
                  85                  90                  95    
 Glu Ala Tyr Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys
             100                 105                 110        
 Gly Asp Thr Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln
         115                 120                 125            
 Ala Asn Arg Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln
     130                 135                 140                
 Asp Ala Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp
 145                 150                 155                 160
 Glu Leu Ala Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu
                 165                 170                 175    
 Arg Ala Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu
             180                 185                 190        
 Glu Ala Ile Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu
         195                 200                 205            
 Thr Leu Val Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg
     210                 215                 220                
 Leu Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile
 225                 230                 235                 240
 Arg Ile Ile Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala
                 245                 250                 255    
 Lys Phe Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser
             260                 265                 270        
 Asp Thr Ser Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His
         275                 280                 285        



      <210> 238
      <211> 183
      <212> PRT
      <213> Homo sapiens


      <400> 238
 Met Thr Thr Ala Ser Pro Ser Gln Val Arg Gln Asn Tyr His Gln Asp
   1               5                  10                  15    
 Ala Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser
              20                  25                  30        
 Tyr Val Tyr Leu Ser Met Ser Cys Tyr Phe Asp Arg Asp Asp Val Ala
          35                  40                  45            
 Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg
      50                  55                  60                
 Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg
  65                  70                  75                  80
 Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Arg Asp Asp Trp Glu Ser
                  85                  90                  95    
 Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Ser Val Asn
             100                 105                 110        
 Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro
         115                 120                 125            
 His Leu Cys Asp Phe Ile Glu Thr Tyr Tyr Leu Ser Glu Gln Val Lys
     130                 135                 140                
 Ser Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly
 145                 150                 155                 160
 Ala Pro Glu Ala Gly Met Ala Glu Tyr Leu Phe Asp Lys His Thr Leu
                 165                 170                 175    
 Gly His Gly Asp Glu Ser
             180        



      <210> 239
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 239
 Met Phe Lys Lys Phe Asp Glu Lys Glu Asn Val Ser Asn Cys Ile Gln
   1               5                  10                  15    
 Leu Lys Thr Ser Val Ile Lys Gly Ile Lys Asn Gln Leu Ile Glu Gln
              20                  25                  30        
 Phe Pro Gly Ile Glu Pro Trp Leu Asn Gln Ile Met Pro Lys Lys Asp
          35                  40                  45            
 Pro Val Lys Ile Val Arg Cys His Glu His Ile Glu Ile Leu Thr Val
      50                  55                  60                
 Asn Gly Glu Leu Leu Phe Phe Arg Gln Arg Glu Gly Pro Phe Tyr Pro
  65                  70                  75                  80
 Thr Leu Arg Leu Leu His Lys Tyr Pro Phe Ile Leu Pro His Gln Gln
                  85                  90                  95    
 Val Asp Lys Gly Ala Ile Lys Phe Val Leu Ser Gly Ala Asn Ile Met
             100                 105                 110        
 Cys Pro Gly Leu Thr Ser Pro Gly Ala Lys Leu Tyr Pro Ala Ala Val
         115                 120                 125            
 Asp Thr Ile Val Ala Ile Met Ala Glu Gly Lys Gln His Ala Leu Cys
     130                 135                 140                
 Val Gly Val Met Lys Met Ser Ala Glu Asp Ile Glu Lys Val Asn Lys
 145                 150                 155                 160
 Gly Ile Gly Ile Glu Asn Ile His Tyr Leu Asn Asp Gly Leu Trp His
                 165                 170                 175    
 Met Lys Thr Tyr Lys
             180    



      <210> 240
      <211> 31
      <212> PRT
      <213> Homo sapiens


      <400> 240
 Met Pro Gly Lys Phe Phe Val Phe Cys Ile Phe Cys Arg Asn Arg Ile
   1               5                  10                  15    
 Ser Pro Cys Trp Pro Gly Trp Ser Arg Thr Pro Gly Leu Asn
              20                  25                  30



      <210> 241
      <211> 378
      <212> PRT
      <213> Homo sapiens


      <400> 241
 Met Leu Ser Ser Cys Val Arg Pro Val Pro Thr Thr Val Arg Phe Val
   1               5                  10                  15    
 Asp Ser Leu Ile Cys Asn Ser Ser Arg Ser Phe Met Asp Leu Lys Ala
              20                  25                  30        
 Leu Leu Ser Ser Leu Asn Asp Phe Ala Ser Leu Ser Phe Ala Glu Ser
          35                  40                  45            
 Trp Asp Asn Val Gly Leu Leu Val Glu Pro Ser Pro Pro His Thr Val
      50                  55                  60                
 Asn Thr Leu Phe Leu Thr Asn Asp Leu Thr Glu Glu Val Met Glu Glu
  65                  70                  75                  80
 Val Leu Gln Lys Lys Ala Asp Leu Ile Leu Ser Tyr His Pro Pro Ile
                  85                  90                  95    
 Phe Arg Pro Met Lys Arg Ile Thr Trp Asn Thr Trp Lys Glu Arg Leu
             100                 105                 110        
 Val Ile Arg Ala Leu Glu Asn Arg Val Gly Ile Tyr Ser Pro His Thr
         115                 120                 125            
 Ala Tyr Asp Ala Ala Pro Gln Gly Val Asn Asn Trp Leu Ala Lys Gly
     130                 135                 140                
 Leu Gly Ala Cys Thr Ser Arg Pro Ile His Pro Ser Lys Ala Pro Asn
 145                 150                 155                 160
 Tyr Pro Thr Glu Gly Asn His Arg Val Glu Phe Asn Val Asn Tyr Thr
                 165                 170                 175    
 Gln Asp Leu Asp Lys Val Met Ser Ala Val Lys Gly Ile Asp Gly Val
             180                 185                 190        
 Ser Val Thr Ser Phe Ser Ala Arg Thr Gly Asn Glu Glu Gln Thr Arg
         195                 200                 205            
 Ile Asn Leu Asn Cys Thr Gln Lys Ala Leu Met Gln Val Val Asp Phe
     210                 215                 220                
 Leu Ser Arg Asn Lys Gln Leu Tyr Gln Lys Thr Glu Ile Leu Ser Leu
 225                 230                 235                 240
 Glu Lys Pro Leu Leu Leu His Thr Gly Met Gly Arg Leu Cys Thr Leu
                 245                 250                 255    
 Asp Glu Ser Val Ser Leu Ala Thr Met Ile Asp Arg Ile Lys Arg His
             260                 265                 270        
 Leu Lys Leu Ser His Ile Arg Leu Ala Leu Gly Val Gly Arg Thr Leu
         275                 280                 285            
 Glu Ser Gln Val Lys Val Val Ala Leu Cys Ala Gly Ser Gly Ser Ser
     290                 295                 300                
 Val Leu Gln Gly Val Glu Ala Asp Leu Tyr Leu Thr Gly Glu Met Ser
 305                 310                 315                 320
 His His Asp Ile Leu Asp Ala Ala Ser Gln Gly Ile Asn Val Ile Leu
                 325                 330                 335    
 Cys Glu His Ser Asn Thr Glu Arg Gly Phe Leu Ser Asp Leu Arg Asp
             340                 345                 350        
 Met Leu Asp Ser His Leu Glu Asn Lys Ile Asn Ile Ile Leu Ser Glu
         355                 360                 365            
 Thr Asp Arg Asp Pro Leu Gln Val Val
     370                 375        



      <210> 242
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 242
 Met His Ser Arg Pro Trp Ala Trp Gly Ala Ser Glu Met Cys Phe Cys
   1               5                  10                  15    
 Phe Phe Glu Met Gly Ser Phe Cys Cys Pro Ser Arg Ser Thr Val Ala
              20                  25                  30        
 Arg Ser Gln Leu Thr Ala Ala Ser Thr Ser Trp Ala Gln Val Ile Leu
          35                  40                  45            
 Pro Pro Gln Pro Pro Glu Cys Leu Leu Leu Val Phe Met Met Thr Trp
      50                  55                  60                
 Gly Pro Gly Ile Leu His Leu Cys Cys Ser Gly Ala Ser Pro Ala Pro
  65                  70                  75                  80
 Gly Ala His Gln Pro Gln Leu Arg Arg Glu Ala Leu Ile Cys Arg Ala
                  85                  90                  95    
 Lys Gln Leu Cys Phe His Val Asp Pro Ala
             100                 105    



      <210> 243
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 243
 Met His His His Val Gln Leu Ile Phe Val Phe Phe Ser Arg Asp Gly
   1               5                  10                  15    
 Val Ser Leu Tyr Val Gly Gln Ala Gly Leu Lys Leu Leu Thr Ser Ser
              20                  25                  30        
 Asp Pro Leu Thr Leu Ala Ser Gln Ser Ala Gly Ile Thr Asp Val Ser
          35                  40                  45            
 His His Ala Arg Pro Gly Phe Ser Thr Leu Glu Gly Ser Ile Leu Leu
      50                  55                  60                
 Ser Leu Gln Leu Ala Val Phe Phe Pro Asp Asn Leu Lys Tyr Asp His
  65                  70                  75                  80
 Thr Thr Ala Cys Thr Gln Gln Asp Ser Leu Ser Cys Pro Trp Gly Lys
                  85                  90                  95    
 Cys Met Pro Asp Leu Phe Asn Ser Val Gln Ser Leu Lys Val Leu Thr
             100                 105                 110        
 Leu Met Phe Tyr Lys Asn Val Glu Ala Thr Arg Cys Tyr Glu Ala Cys
         115                 120                 125            





      <210> 244
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 244
 Met Ala Leu Trp Arg Ala Tyr Gln Arg Ala Leu Ala Ala His Pro Trp
   1               5                  10                  15    
 Lys Val Gln Val Leu Thr Ala Gly Ser Leu Met Gly Leu Gly Asp Ile
              20                  25                  30        
 Ile Ser Gln Gln Leu Val Glu Arg Arg Gly Leu Gln Glu His Gln Arg
          35                  40                  45            
 Gly Arg Thr Leu Thr Met Val Ser Leu Gly Cys Gly Phe Val Gly Pro
      50                  55                  60                
 Val Val Gly Gly Trp Tyr Lys Val Leu Asp Arg Phe Ile Pro Gly Thr
  65                  70                  75                  80
 Thr Lys Val Asp Ala Leu Lys Lys Met Leu Leu Asp Gln Gly Gly Phe
                  85                  90                  95    
 Ala Pro Cys Phe Leu Gly Cys Phe Leu Pro Leu Asp Tyr Pro Asp Ala
             100                 105                 110        
 Leu Ile Thr Asn Tyr Tyr Leu Trp Pro Ala Val Gln Leu Ala Asn Phe
         115                 120                 125            
 Tyr Leu Val Pro Leu His Tyr Arg Leu Ala Val Val Gln Cys Val Ala
     130                 135                 140                
 Val Ile Trp Asn Ser Tyr Leu Ser Trp Lys Ala His Arg Leu
 145                 150                 155            



      <210> 245
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 245
 Met Gly Pro Pro Ser Ala Cys Pro His Arg Glu Cys Ile Pro Trp Gln
   1               5                  10                  15    
 Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Ala Pro Thr
              20                  25                  30        
 Thr Ala Trp Leu Phe Ile Ala Ser Ala Pro Phe Glu Val Ala Glu Gly
          35                  40                  45            
 Glu Asn Val His Leu Ser Val Val Tyr Leu Pro Glu Asn Leu Tyr Ser
      50                  55                  60                
 Tyr Gly Trp Tyr Lys Gly Lys Thr Val Glu Pro Asn Gln Leu Ile Ala
  65                  70                  75                  80
 Ala Tyr Val Ile Asp Asp Thr His Val Arg Thr Pro Gly Pro Ala Tyr
                  85                  90                  95    
 Ser Gly Arg Glu Thr Ile Ser Pro Ser Gly Asp Leu His Phe Gln Lys
             100                 105                 110        
 Val Thr Leu Glu Asp Thr Gly Tyr Tyr Thr Leu Gln Val Thr Tyr Arg
         115                 120                 125            
 Asn Ser Gln Ile Glu Gln Ala Ser His His Leu Arg Val Tyr Glu Ser
     130                 135                 140                
 Val Ala Gln Pro Ser Ile Gln Ala Ser Ser Thr Thr Val Thr Glu Lys
 145                 150                 155                 160
 Gly Ser Val Val Leu Thr Cys His Thr Asn Asn Thr Gly Thr Ser Phe
                 165                 170                 175    
 Gln Trp Ile Phe Asn Thr Gln Arg Leu Gln Val Thr Lys Arg Met Lys
             180                 185                 190        
 Leu Ser Trp Phe Asn His Met Leu Thr Ile Asp Pro Ile Arg Gln Glu
         195                 200                 205            
 Asp Ala Gly Glu Asn Gln Trp Glu Val Ser Asn Pro Ile Ser Ser Asn
     210                 215                 220                
 Arg Ser Asp Pro Leu Lys Leu Thr Gly Lys
 225                 230                



      <210> 246
      <211> 519
      <212> PRT
      <213> Homo sapiens


      <400> 246
 Met Glu Cys Asp Leu Met Glu Thr Asp Ile Leu Glu Ser Leu Glu Asp
   1               5                  10                  15    
 Leu Gly Tyr Lys Gly Pro Leu Leu Glu Asp Gly Ala Leu Ser Gln Ala
              20                  25                  30        
 Val Ser Ala Gly Ala Ser Ser Pro Glu Phe Thr Lys Leu Cys Ala Trp
          35                  40                  45            
 Leu Val Ser Glu Leu Arg Val Leu Cys Lys Leu Glu Glu Asn Val Gln
      50                  55                  60                
 Ala Thr Asn Ser Pro Ser Glu Ala Glu Glu Phe Gln Leu Glu Val Ser
  65                  70                  75                  80
 Gly Leu Leu Gly Glu Met Asn Cys Pro Tyr Leu Ser Leu Thr Ser Gly
                  85                  90                  95    
 Asp Val Thr Lys Arg Leu Leu Ile Gln Lys Asn Cys Leu Leu Leu Leu
             100                 105                 110        
 Thr Tyr Leu Ile Ser Glu Leu Glu Ala Ala Arg Met Leu Cys Val Asn
         115                 120                 125            
 Ala Pro Pro Lys Lys Ala Gln Glu Gly Gly Gly Ser Glu Val Phe Gln
     130                 135                 140                
 Glu Leu Lys Gly Ile Cys Ile Ala Leu Gly Met Ser Lys Pro Pro Ala
 145                 150                 155                 160
 Asn Ile Thr Met Phe Gln Phe Phe Ser Gly Ile Glu Lys Lys Leu Lys
                 165                 170                 175    
 Glu Thr Leu Ala Lys Val Pro Pro Asn His Val Gly Lys Pro Leu Leu
             180                 185                 190        
 Lys Lys Pro Met Gly Pro Ala His Trp Glu Lys Ile Glu Ala Ile Asn
         195                 200                 205            
 Gln Ala Ile Ala Asn Glu Tyr Glu Val Arg Arg Lys Leu Leu Ile Lys
     210                 215                 220                
 Arg Leu Asp Val Thr Val Gln Ser Phe Gly Trp Ser Asp Arg Ala Lys
 225                 230                 235                 240
 Ser Gln Thr Glu Lys Leu Ala Lys Val Tyr Gln Pro Lys Arg Ser Val
                 245                 250                 255    
 Leu Ser Pro Lys Thr Thr Ile Ser Val Ala His Leu Leu Ala Ala Arg
             260                 265                 270        
 Gln Asp Leu Ser Lys Ile Leu Arg Thr Ser Ser Gly Ser Ile Arg Glu
         275                 280                 285            
 Lys Thr Ala Cys Ala Ile Asn Lys Val Leu Met Gly Arg Val Pro Asp
     290                 295                 300                
 Arg Gly Gly Arg Pro Asn Glu Ile Glu Pro Pro Pro Pro Glu Met Pro
 305                 310                 315                 320
 Pro Trp Gln Lys Arg Gln Asp Gly Pro Gln Gln Gln Thr Gly Gly Arg
                 325                 330                 335    
 Gly Gly Gly Arg Gly Gly Tyr Glu His Ser Ser Tyr Gly Gly Arg Gly
             340                 345                 350        
 Gly His Glu Gln Gly Gly Gly Arg Gly Gly Arg Gly Gly Tyr Asp His
         355                 360                 365            
 Gly Gly Arg Gly Gly Gly Arg Gly Asn Lys His Gln Gly Gly Trp Thr
     370                 375                 380                
 Asp Gly Gly Ser Gly Gly Gly Gly Gly Tyr Gln Asp Gly Gly Tyr Arg
 385                 390                 395                 400
 Asp Ser Gly Phe Gln Pro Gly Gly Tyr His Gly Gly His Ser Ser Gly
                 405                 410                 415    
 Gly Tyr Gln Gly Gly Gly Tyr Gly Gly Phe Gln Thr Ser Ser Ser Tyr
             420                 425                 430        
 Thr Gly Ser Gly Tyr Gln Gly Gly Gly Tyr Gln Gln Asp Asn Arg Tyr
         435                 440                 445            
 Gln Asp Gly Gly His His Gly Asp Arg Gly Gly Gly Arg Gly Gly Arg
     450                 455                 460                
 Gly Gly Arg Gly Gly Arg Gly Gly Arg Ala Gly Gln Gly Gly Gly Trp
 465                 470                 475                 480
 Gly Gly Arg Gly Ser Gln Asn Tyr His Gln Gly Gly Gln Phe Glu Gln
                 485                 490                 495    
 His Phe Gln His Gly Gly Tyr Gln Tyr Asn His Ser Gly Phe Gly Gln
             500                 505                 510        
 Gly Arg His Tyr Thr Ser
         515            



      <210> 247
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 247
 Met Leu Lys Glu Ser Asn Phe Ala Asp Ser Tyr Tyr Asp Tyr Ile Cys
   1               5                  10                  15    
 Ile Ile Asp Phe Glu Ala Thr Cys Glu Glu Gly Asn Pro Pro Glu Phe
              20                  25                  30        
 Val His Glu Ile Ile Glu Phe Pro Val Val Leu Leu Asn Thr His Thr
          35                  40                  45            
 Leu Glu Ile Glu Asp Thr Phe Gln Gln Tyr Val Arg Pro Glu Ile Asn
      50                  55                  60                
 Thr Gln Leu Ser Asp Phe Cys Ile Ser Leu Thr Gly Ile Thr Gln Asp
  65                  70                  75                  80
 Gln Val Asp Arg Ala Asp Thr Phe Pro Gln Val Leu Lys Lys Val Ile
                  85                  90                  95    
 Asp Trp Met Lys Leu Lys Glu Leu Gly Thr Lys Tyr Lys Tyr Ser Leu
             100                 105                 110        
 Leu Thr Asp Gly Ser Trp Asp Met Ser Lys Phe Leu Asn Ile Gln Cys
         115                 120                 125            
 Gln Leu Ser Arg Leu Lys Tyr Pro Pro Phe Ala Lys Lys Trp Ile Asn
     130                 135                 140                
 Ile Arg Lys Ser Tyr Gly Asn Phe Tyr Lys Val Pro Arg Ser Gln Thr
 145                 150                 155                 160
 Lys Leu Thr Ile Met Leu Glu Lys Leu Gly Met Asp Tyr Asp Gly Arg
                 165                 170                 175    
 Pro His Cys Gly Leu Asp Asp Ser Lys Asn Ile Ala Arg Ile Ala Val
             180                 185                 190        
 Arg Met Leu Gln Asp Gly Cys Glu Leu Arg Ile Asn Glu Lys Met His
         195                 200                 205            
 Ala Gly Gln Leu Met Ser Val Ser Ser Ser Leu Pro Ile Glu Gly Thr
     210                 215                 220                
 Pro Pro Pro Gln Met Pro His Phe Arg Lys
 225                 230                



      <210> 248
      <211> 175
      <212> PRT
      <213> Homo sapiens


      <400> 248
 Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp
   1               5                  10                  15    
 Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu
              20                  25                  30        
 Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp
          35                  40                  45            
 Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His
      50                  55                  60                
 Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp
  65                  70                  75                  80
 Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys
                  85                  90                  95    
 Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val
             100                 105                 110        
 Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln
         115                 120                 125            
 Pro His Leu Ser Val Val Trp Leu Met Pro Trp Pro Thr Thr Pro Gly
     130                 135                 140                
 Gln Arg Ala Gly Leu Cys Ala Gly Pro Ser Leu Trp Gln Ile Ile His
 145                 150                 155                 160
 Pro Thr Ser Ala Gly Cys Leu Ser Glu Ser Gly Gly Trp Cys Gly
                 165                 170                 175



      <210> 249
      <211> 28
      <212> PRT
      <213> Homo sapiens


      <400> 249
 Met Glu Pro Gly Gln His Gly Lys Thr Pro Pro Pro Leu Lys Ile Gln
   1               5                  10                  15    
 Arg Leu Ala Gly His Ser Arg Cys Leu Gly Gly
              20                  25        



      <210> 250
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 250
 Met Phe Cys Gln Gly Leu Thr Glu Val Ser Gly Leu Trp Ile Gln Leu
   1               5                  10                  15    
 Val Asp Ile Thr Gly Asp Leu Arg Gln Gln Leu Leu Leu Leu Gly Leu
              20                  25                  30        
 Cys Asp Pro Pro Lys Pro Asp Gly Ile Met Arg His Pro His Cys Lys
          35                  40                  45            
 Ala Phe Leu Lys Pro Thr Val Leu Thr Phe Ile Ser Thr Phe Phe Val
      50                  55                  60                
 Asp Pro Thr Val Lys Ile Thr Ser Val Ile Asp Lys Leu Gln Ser Asp
  65                  70                  75                  80
 Cys Ser Pro Glu Glu Thr Leu Ala Ser Phe Thr Ser Met Asn Ser Ile
                  85                  90                  95    
 Val Lys Ser Arg Ser Phe Ile Ser Thr Asp Thr Thr Phe Asn Cys His
             100                 105                 110        
 Glu Gly Val Gly Arg Leu Phe Met Arg Leu Ile Val Glu Leu Ser Leu
         115                 120                 125            
 Leu Arg Ile Ile Arg Trp Arg Cys Arg Leu His Phe Asp Cys Thr Leu
     130                 135                 140                
 Val Leu Leu Lys Phe Gln Val Ile Leu Val Ile Cys Asn His Trp Ile
 145                 150                 155                 160
 Cys Ser Cys Glu Trp Asn Val Phe Val Met Trp Ser Arg Asn Ala Gly
                 165                 170                 175    
 Glu Val Asn Ser Ser Glu Gly Leu Asp Ile Lys Gly Val Gly Val Val
             180                 185                 190        
 Phe His Tyr Gly Glu Ile His Gly Ala Asp Pro Lys Val Gly Gly Pro
         195                 200                 205            
 Glu Cys Asp Leu Cys Val Asn His Gly His Phe Cys Gly His Gly Gly
     210                 215                 220                
 Val Ala Pro Leu Ser Gly Val Leu Glu Ala Asp Pro Ser Pro Pro Gly
 225                 230                 235                 240
 Gly Gly Cys Gly Ser Gly Ser Gly Ile Pro Gln Thr Gln Arg Glu Pro
                 245                 250                 255    
 Thr Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp
             260                 265                 270        
 Gly Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu
         275                 280                 285            
 Arg Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe
     290                 295                 300                
 Asp Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val
 305                 310                 315                 320
 Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn
                 325                 330                 335    
 Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp
             340                 345                 350        
 Pro Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala
         355                 360                 365            
 Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp
     370                 375                 380                
 Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
 385                 390                 395                



      <210> 251
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 251
 Met Asp Asn Gly Asp Trp Gly Tyr Met Met Thr Asp Pro Val Thr Leu
   1               5                  10                  15    
 Asn Val Gly Gly His Leu Tyr Thr Thr Ser Leu Thr Thr Leu Thr Arg
              20                  25                  30        
 Tyr Pro Asp Ser Met Leu Gly Ala Met Phe Gly Gly Asp Phe Pro Thr
          35                  40                  45            
 Ala Arg Asp Pro Gln Gly Asn Tyr Phe Ile Asp Arg Asp Gly Pro Leu
      50                  55                  60                
 Phe Arg Tyr Val Leu Asn Phe Leu Arg Thr Ser Glu Leu Thr Leu Pro
  65                  70                  75                  80
 Leu Asp Phe Lys Glu Phe Asp Leu Leu Arg Lys Glu Ala Asp Phe Tyr
                  85                  90                  95    
 Gln Ile Glu Pro Leu Ile Gln Cys Leu Asn Asp Pro Lys Pro Leu Tyr
             100                 105                 110        
 Pro Met Asp Thr Phe Glu Glu Val Val Glu Leu Ser Ser Thr Arg Lys
         115                 120                 125            
 Leu Ser Lys Tyr Ser Asn Pro Val Ala Val Ile Ile Thr Gln Leu Thr
     130                 135                 140                
 Ile Thr Thr Lys Val His Ser Leu Leu Glu Gly Ile Ser Asn Tyr Phe
 145                 150                 155                 160
 Thr Lys Trp Asn Lys His Met Met Asp Thr Arg Asp Cys Gln Val Ser
                 165                 170                 175    
 Phe Thr Phe Gly Pro Cys Asp Tyr His Gln Glu Val Ser Leu Arg Val
             180                 185                 190        
 His Leu Met Glu Tyr Ile Thr Lys Gln Gly Phe Thr Ile Arg Asn Thr
         195                 200                 205            
 Arg Val His His Met Ser Glu Arg Ala Asn Glu Asn Thr Val Glu His
     210                 215                 220                
 Asn Trp Thr Phe Cys Arg Leu Ala Arg Lys Thr Asp Asp
 225                 230                 235        



      <210> 252
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 252
 Met Ala Ser Ala Ser Thr Gln Pro Ala Ala Leu Ser Ala Glu Gln Ala
   1               5                  10                  15    
 Lys Val Val Leu Ala Glu Val Ile Gln Ala Phe Ser Ala Pro Glu Asn
              20                  25                  30        
 Ala Val Arg Met Asp Glu Ala Arg Asp Asn Ala Cys Asn Asp Met Gly
          35                  40                  45            
 Lys Met Leu Gln Phe Val Leu Pro Val Ala Thr Gln Ile Gln Gln Glu
      50                  55                  60                
 Val Ile Lys Ala Tyr Gly Phe Ser Cys Asp Gly Glu Gly Val Leu Lys
  65                  70                  75                  80
 Phe Ala Arg Leu Val Lys Ser Tyr Glu Ala Gln Asp Pro Glu Ile Ala
                  85                  90                  95    
 Ser Leu Ser Gly Lys Leu Lys Ala Leu Phe Leu Pro Pro Met Thr Leu
             100                 105                 110        
 Pro Pro His Gly Pro Ala Ala Gly Gly Ser Val Ala Ala Ser
         115                 120                 125    



      <210> 253
      <211> 586
      <212> PRT
      <213> Homo sapiens


      <400> 253
 Met Gly Ser Leu Lys Glu Glu Leu Leu Lys Ala Ile Trp His Ala Phe
   1               5                  10                  15    
 Thr Ala Leu Asp Gln Asp His Ser Gly Lys Val Ser Lys Ser Gln Leu
              20                  25                  30        
 Lys Val Leu Ser His Asn Leu Cys Thr Val Leu Lys Val Pro His Asp
          35                  40                  45            
 Pro Val Ala Leu Glu Glu His Phe Arg Asp Asp Asp Glu Gly Pro Val
      50                  55                  60                
 Ser Asn Gln Gly Tyr Met Pro Tyr Leu Asn Arg Phe Ile Leu Glu Lys
  65                  70                  75                  80
 Val Gln Asp Asn Phe Asp Lys Ile Glu Phe Asn Arg Met Cys Trp Thr
                  85                  90                  95    
 Leu Cys Val Lys Lys Asn Leu Thr Lys Asn Pro Leu Leu Ile Thr Glu
             100                 105                 110        
 Glu Asp Ala Phe Lys Ile Trp Val Ile Phe Asn Phe Leu Ser Glu Asp
         115                 120                 125            
 Lys Tyr Pro Leu Ile Ile Val Ser Glu Glu Ile Glu Tyr Leu Leu Lys
     130                 135                 140                
 Lys Leu Thr Glu Ala Met Gly Gly Gly Trp Gln Gln Glu Gln Phe Glu
 145                 150                 155                 160
 His Tyr Lys Ile Asn Phe Asp Asp Ser Lys Asn Gly Leu Ser Ala Trp
                 165                 170                 175    
 Glu Leu Ile Glu Leu Ile Gly Asn Gly Gln Phe Ser Lys Gly Met Asp
             180                 185                 190        
 Arg Gln Thr Val Ser Met Ala Ile Asn Glu Val Phe Asn Glu Leu Ile
         195                 200                 205            
 Leu Asp Val Leu Lys Gln Gly Tyr Met Met Lys Lys Gly His Arg Arg
     210                 215                 220                
 Lys Asn Trp Thr Glu Arg Trp Phe Val Leu Lys Pro Asn Ile Ile Ser
 225                 230                 235                 240
 Tyr Tyr Val Ser Glu Asp Leu Lys Asp Lys Lys Gly Asp Ile Leu Leu
                 245                 250                 255    
 Asp Glu Asn Cys Cys Val Glu Ser Leu Pro Asp Lys Asp Gly Lys Lys
             260                 265                 270        
 Cys Leu Phe Leu Val Lys Cys Phe Asp Lys Thr Phe Glu Ile Ser Ala
         275                 280                 285            
 Ser Asp Lys Lys Lys Lys Gln Glu Trp Ile Gln Ala Ile His Ser Thr
     290                 295                 300                
 Ile His Leu Leu Lys Leu Gly Ser Pro Pro Pro His Lys Glu Ala Arg
 305                 310                 315                 320
 Gln Arg Arg Lys Glu Leu Arg Lys Lys Gln Leu Ala Glu Gln Glu Glu
                 325                 330                 335    
 Leu Glu Arg Gln Met Lys Glu Leu Gln Ala Ala Asn Glu Ser Lys Gln
             340                 345                 350        
 Gln Glu Leu Glu Ala Val Arg Lys Lys Leu Glu Glu Ala Ala Ser Arg
         355                 360                 365            
 Ala Ala Glu Glu Glu Lys Lys Arg Leu Gln Thr Gln Val Glu Leu Gln
     370                 375                 380                
 Ala Arg Phe Ser Thr Glu Leu Glu Arg Glu Lys Leu Ile Arg Gln Gln
 385                 390                 395                 400
 Met Glu Glu Gln Val Ala Gln Lys Ser Ser Glu Leu Glu Gln Tyr Leu
                 405                 410                 415    
 Gln Arg Val Arg Glu Leu Glu Asp Met Tyr Leu Lys Leu Gln Glu Ala
             420                 425                 430        
 Leu Glu Asp Glu Arg Gln Ala Arg Gln Asp Glu Glu Thr Val Arg Lys
         435                 440                 445            
 Leu Gln Ala Arg Leu Leu Glu Glu Glu Ser Ser Lys Arg Ala Glu Leu
     450                 455                 460                
 Glu Lys Trp His Leu Glu Gln Gln Gln Ala Ile Gln Thr Thr Glu Ala
 465                 470                 475                 480
 Glu Lys Gln Glu Leu Glu Asn Gln Arg Val Leu Lys Glu Gln Ala Leu
                 485                 490                 495    
 Gln Glu Ala Met Glu Gln Leu Glu Glu Leu Glu Leu Glu Arg Lys Gln
             500                 505                 510        
 Ala Leu Glu Gln Tyr Glu Glu Val Lys Lys Lys Leu Glu Met Ala Thr
         515                 520                 525            
 Asn Lys Thr Lys Ser Trp Lys Asp Lys Val Ala His His Glu Gly Leu
     530                 535                 540                
 Ile Arg Leu Ile Glu Pro Gly Ser Lys Asn Pro His Leu Ile Thr Asn
 545                 550                 555                 560
 Trp Gly Pro Ala Ala Phe Thr Glu Ala Glu Leu Glu Glu Arg Glu Lys
                 565                 570                 575    
 Asn Trp Lys Glu Lys Lys Thr Thr Glu
             580                 585



      <210> 254
      <211> 1035
      <212> PRT
      <213> Homo sapiens


      <400> 254
 Met Ala Ser Val Phe Met Cys Gly Val Glu Asp Leu Leu Phe Ser Gly
   1               5                  10                  15    
 Ser Arg Phe Val Trp Asn Leu Thr Val Ser Thr Leu Arg Arg Trp Tyr
              20                  25                  30        
 Thr Glu Arg Leu Arg Ala Cys His Gln Val Leu Arg Thr Trp Cys Gly
          35                  40                  45            
 Leu Gln Asp Val Tyr Gln Met Thr Glu Gly Arg His Cys Gln Val His
      50                  55                  60                
 Leu Leu Asp Asp Arg Arg Leu Glu Leu Leu Val Gln Pro Lys Leu Leu
  65                  70                  75                  80
 Ala Arg Glu Leu Leu Asp Leu Val Ala Ser His Phe Asn Leu Lys Glu
                  85                  90                  95    
 Lys Glu Tyr Phe Gly Ile Thr Phe Ile Asp Asp Thr Gly Gln Gln Asn
             100                 105                 110        
 Trp Leu Gln Leu Asp His Arg Val Leu Asp His Asp Leu Pro Lys Lys
         115                 120                 125            
 Pro Gly Pro Thr Ile Leu His Phe Ala Val Arg Phe Tyr Ile Glu Ser
     130                 135                 140                
 Ile Ser Phe Leu Lys Asp Lys Thr Thr Val Glu Leu Phe Phe Leu Asn
 145                 150                 155                 160
 Ala Lys Ala Cys Val His Lys Gly Gln Ile Glu Val Glu Ser Glu Thr
                 165                 170                 175    
 Ile Phe Lys Leu Ala Ala Phe Ile Leu Gln Glu Ala Lys Gly Asp Tyr
             180                 185                 190        
 Thr Ser Asp Glu Asn Ala Arg Lys Asp Leu Lys Thr Leu Pro Ala Phe
         195                 200                 205            
 Pro Thr Lys Thr Leu Gln Glu His Pro Ser Leu Ala Tyr Cys Glu Asp
     210                 215                 220                
 Arg Val Ile Glu His Tyr Leu Lys Ile Lys Gly Leu Thr Arg Gly Gln
 225                 230                 235                 240
 Ala Val Val Gln Tyr Met Lys Ile Val Glu Ala Leu Pro Thr Tyr Gly
                 245                 250                 255    
 Val His Tyr Tyr Ala Val Lys Asp Lys Gln Gly Leu Pro Trp Trp Leu
             260                 265                 270        
 Gly Ile Ser Tyr Lys Gly Ile Gly Gln Tyr Asp Ile Gln Asp Lys Val
         275                 280                 285            
 Lys Pro Arg Lys Leu Phe Gln Trp Lys Gln Leu Glu Asn Leu Tyr Phe
     290                 295                 300                
 Arg Glu Lys Lys Phe Ala Val Glu Val His Asp Pro Arg Arg Ile Ser
 305                 310                 315                 320
 Val Ser Arg Arg Thr Phe Gly Gln Ser Gly Leu Phe Val Gln Thr Trp
                 325                 330                 335    
 Tyr Ala Asn Ser Ser Leu Ile Lys Ser Ile Trp Val Met Ala Ile Ser
             340                 345                 350        
 Gln His Gln Phe Tyr Leu Asp Arg Lys Gln Ser Lys Ala Lys Ile Pro
         355                 360                 365            
 Ser Ala Arg Ser Leu Asp Glu Ile Ala Met Asp Leu Thr Glu Thr Gly
     370                 375                 380                
 Thr Gln Arg Ala Ser Lys Leu Val Thr Leu Glu Ala Lys Ser Gln Phe
 385                 390                 395                 400
 Ile Met Ala Ser Asn Gly Ser Leu Ile Ser Ser Gly Ser Gln Asp Ser
                 405                 410                 415    
 Glu Val Ser Glu Glu Gln Lys Arg Glu Lys Ile Leu Glu Leu Lys Lys
             420                 425                 430        
 Lys Glu Lys Leu Leu Gln Glu Lys Leu Leu Lys Lys Val Glu Glu Leu
         435                 440                 445            
 Lys Lys Ile Cys Leu Arg Glu Ala Glu Leu Thr Gly Lys Met Pro Lys
     450                 455                 460                
 Glu Tyr Pro Leu Asn Ile Gly Glu Lys Pro Pro Gln Val Arg Arg Arg
 465                 470                 475                 480
 Val Gly Thr Ala Phe Lys Leu Asp Asp Asn Leu Leu Pro Ser Glu Glu
                 485                 490                 495    
 Asp Pro Ala Leu Gln Glu Leu Glu Ser Asn Phe Leu Ile Gln Gln Lys
             500                 505                 510        
 Leu Val Glu Ala Ala Lys Lys Leu Ala Asn Glu Pro Asp Leu Cys Lys
         515                 520                 525            
 Thr Val Lys Lys Lys Arg Lys Gln Asp Tyr Thr Asp Ala Met Lys Lys
     530                 535                 540                
 Leu Gln Glu Ile Glu Asn Ala Ile Asn Glu Tyr Arg Ile Arg Cys Gly
 545                 550                 555                 560
 Lys Lys Pro Ser Gln Lys Ala Thr Val Leu Pro Glu Asp Ile Ile Pro
                 565                 570                 575    
 Ser Glu Ser Ser Ser Leu Ser Asp Thr Thr Thr Tyr Asp Asp Pro Ser
             580                 585                 590        
 Asp Ala Phe Thr Phe Pro Gly Gln Arg Ser Ser Ser Val Pro His Ser
         595                 600                 605            
 Pro Arg Ile Leu Pro Pro Lys Ser Leu Gly Ile Glu Arg Ile His Phe
     610                 615                 620                
 Arg Lys Ser Ser Ile Asn Glu Gln Phe Val Asp Thr Arg Gln Ser Arg
 625                 630                 635                 640
 Glu Met Leu Ser Thr His Ser Ser Pro Tyr Lys Thr Leu Glu Arg Arg
                 645                 650                 655    
 Pro Gln Gly Gly Arg Ser Met Pro Thr Thr Pro Val Leu Thr Arg Asn
             660                 665                 670        
 Ala Tyr Ser Ser Ser His Leu Glu Pro Glu Ser Ser Ser Gln His Cys
         675                 680                 685            
 Arg Gln Arg Ser Gly Ser Leu Glu Ser Gln Ser His Leu Leu Ser Glu
     690                 695                 700                
 Met Asp Ser Asp Lys Pro Phe Phe Ser Leu Ser Lys Ser Gln Arg Ser
 705                 710                 715                 720
 Ser Ser Thr Glu Ile Leu Asp Asp Gly Ser Ser Tyr Thr Ser Gln Ser
                 725                 730                 735    
 Ser Thr Glu Tyr Tyr Cys Val Thr Pro Val Thr Gly Pro Tyr Tyr Thr
             740                 745                 750        
 Thr Gln Thr Leu Asp Thr Arg Thr Arg Gly Arg Arg Arg Ser Lys Lys
         755                 760                 765            
 Gln Asn Val Ser Thr Ser Asn Ser Gly Ser Met Pro Asn Leu Ala Gln
     770                 775                 780                
 Lys Asp Ser Leu Arg Asn Gly Val Tyr Ser Lys Ser Gln Glu Pro Pro
 785                 790                 795                 800
 Ser Ser Ser Tyr Tyr Ile Ala Gly Tyr Thr Pro Tyr Ala Glu Cys Asp
                 805                 810                 815    
 Phe Tyr Tyr Ser Gly Gly Tyr Val Tyr Glu Asn Asp Thr Glu Gly Gln
             820                 825                 830        
 Tyr Ser Val Asn Pro Ser Tyr Arg Ser Ser Ala His Tyr Gly Tyr Glu
         835                 840                 845            
 Arg Gln Arg Asp Tyr Ser Arg Ser Phe His Glu Asp Glu Val Asp Arg
     850                 855                 860                
 Val Pro His Asn Pro Tyr Ala Thr Leu Arg Leu Pro Arg Lys Ala Ala
 865                 870                 875                 880
 Ala Lys Ser Glu His Ile Thr Lys Asn Ile His Lys Ala Leu Val Ala
                 885                 890                 895    
 Glu His Leu Arg Gly Trp Tyr Gln Arg Ala Ser Gly Gln Lys Asp Gln
             900                 905                 910        
 Gly His Ser Pro Gln Thr Ser Phe Asp Ser Asp Arg Gly Ser Gln Arg
         915                 920                 925            
 Cys Leu Gly Phe Ala Gly Leu Gln Val Pro Cys Ser Pro Ser Ser Arg
     930                 935                 940                
 Ala Ser Leu Tyr Ser Ser Val Ser Ser Thr Asn Ala Ser Gly Asn Trp
 945                 950                 955                 960
 Arg Thr Gln Leu Thr Ile Gly Leu Ser Asp Tyr Glu Thr Pro Ala His
                 965                 970                 975    
 Ser Ser Tyr Thr Ser Cys Tyr Gly Asn Val Tyr Asn Pro Leu Pro Ser
             980                 985                 990        
 Pro Ser Arg Gln Tyr Thr Glu Ile Ser Gln Leu Asp Gly Thr Asp Gly
         995                1000                1005            
 Asn Gln Leu Glu Asp Asn Leu Glu Ser Ser Glu Gln Arg Leu Phe Trp
    1010                1015                1020                
 His Glu Asp Ser Lys Pro Gly Thr Leu Val
1025                1030                



      <210> 255
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 255
 Met Leu Asn Leu Val Asp Lys Ser Pro Ile Tyr Leu Ile Leu Ser Tyr
   1               5                  10                  15    
 Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Ser Asn Leu
              20                  25                  30        
 Ser Ile Tyr Leu Val Leu Lys Ala Ser Arg Ser Val Ala Gln Ala Gly
          35                  40                  45            
 Val Gln Trp Leu Asp Pro Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe
      50                  55                  60                
 Lys Gln Phe Ser Cys Leu Cys Leu Pro Ser Ser Trp Asp Tyr Arg Cys
  65                  70                  75                  80
 Thr Pro Pro Arg Pro Ala
                  85    



      <210> 256
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 256
 Met Asp Arg Ser Asn Pro Val Lys Pro Ala Leu Asp Tyr Phe Ser Asn
   1               5                  10                  15    
 Arg Leu Val Asn Tyr His Ile Ser Val Lys Cys Ser Asn Gln Phe Lys
              20                  25                  30        
 Leu Glu Val Cys Leu Leu Lys Ser Glu Asn Lys Val Val Asp Asn Gln
          35                  40                  45            
 Ala Gly Thr Gln Gly Gln Leu Lys Val Leu Gly Ala Asn Leu Trp Trp
      50                  55                  60                
 Pro Tyr Leu Met His Glu His Pro Ala Tyr Leu Tyr Ser Trp Glu Asp
  65                  70                  75                  80
 Gly Asp Cys Ser His Gln Ser Leu Gly Pro Leu Pro Ala Cys Asp Leu
                  85                  90                  95    
 Trp Asp Gln Leu His Leu Arg Ser Arg Gln Gly Gly Ser Val Cys Gly
             100                 105                 110        
 Cys Asp Pro Cys Glu Gln Leu Leu Leu Leu Val Ser Gln Leu Arg Ala
         115                 120                 125            
 Pro Gly Val Asp Ser Ala Ala Ala Gly Arg Pro Val
     130                 135                 140



      <210> 257
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 257
 Met Leu Ala Phe Ile Pro Val Leu Thr Lys Lys Ile Asn Pro Arg Ser
   1               5                  10                  15    
 Thr Glu Ala Ala Ile Lys Tyr Phe Leu Thr Gln Ala Thr Ala Ser Ile
              20                  25                  30        
 Ile Leu Leu Ile Ala Ile Leu Phe Asn Asn Ile Leu Ser Gly Gln
          35                  40                  45        



      <210> 258
      <211> 66
      <212> PRT
      <213> Homo sapiens


      <400> 258
 Met Cys Ile Leu Phe Cys Phe Ala Leu Leu Cys Phe Glu Thr Glu Ser
   1               5                  10                  15    
 Arg Ser Val Ile Gln Ala Gly Val Gln Trp His Asp Leu Gly Ser Leu
              20                  25                  30        
 Gln Pro Pro Ser Pro Arg Phe Lys Arg Phe Ser Cys Leu Leu Leu Ser
          35                  40                  45            
 Ser Trp Asp Tyr Arg Cys Ser Pro Pro His Pro Ala Asn Phe Leu Tyr
      50                  55                  60                
 Phe
  65



      <210> 259
      <211> 293
      <212> PRT
      <213> Homo sapiens


      <400> 259
 Met Leu Arg Val Leu Cys Leu Leu Arg Pro Trp Arg Pro Leu Arg Ala
   1               5                  10                  15    
 Arg Gly Cys Ala Ser Asp Gly Ala Ala Gly Gly Ser Glu Ile Gln Val
              20                  25                  30        
 Arg Ala Leu Ala Gly Pro Asp Gln Gly Ile Thr Glu Ile Leu Met Asn
          35                  40                  45            
 Arg Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser Glu Leu
      50                  55                  60                
 Leu Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg Val Leu
  65                  70                  75                  80
 Leu Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala Asp Leu
                  85                  90                  95    
 Lys Glu Arg Glu Gln Met Ser Glu Ala Glu Val Gly Val Phe Val Gln
             100                 105                 110        
 Arg Leu Arg Gly Leu Met Asn Asp Ile Ala Ala Phe Pro Ala Pro Thr
         115                 120                 125            
 Ile Ala Ala Met Asp Gly Phe Ala Leu Gly Gly Gly Leu Glu Leu Ala
     130                 135                 140                
 Leu Ala Cys Asp Leu Arg Val Ala Ala Ser Ser Ala Val Met Gly Leu
 145                 150                 155                 160
 Ile Glu Thr Thr Arg Gly Leu Leu Pro Gly Ala Gly Gly Thr Gln Arg
                 165                 170                 175    
 Leu Pro Arg Cys Leu Gly Val Ala Leu Ala Lys Glu Leu Ile Phe Thr
             180                 185                 190        
 Gly Arg Arg Leu Ser Gly Thr Glu Ala His Val Leu Gly Leu Val Asn
         195                 200                 205            
 His Ala Val Ala Gln Asn Glu Glu Gly Asp Ala Ala Tyr Gln Arg Ala
     210                 215                 220                
 Arg Ala Leu Ala Gln Glu Ile Leu Pro Gln Ala Pro Ile Ala Val Arg
 225                 230                 235                 240
 Leu Gly Lys Val Ala Ile Asp Arg Gly Thr Glu Val Asp Ile Ala Ser
                 245                 250                 255    
 Gly Met Ala Ile Glu Gly Met Cys Tyr Ala Gln Asn Ile Pro Thr Arg
             260                 265                 270        
 Asp Arg Leu Glu Gly Met Ala Ala Phe Arg Glu Lys Arg Thr Pro Lys
         275                 280                 285            
 Phe Val Gly Lys
     290        



      <210> 260
      <211> 277
      <212> PRT
      <213> Homo sapiens


      <400> 260
 Met Leu Arg Val Leu Cys Leu Leu Arg Pro Trp Arg Pro Leu Arg Ala
   1               5                  10                  15    
 Arg Gly Cys Ala Ser Asp Gly Ala Ala Gly Gly Ser Glu Ile Gln Val
              20                  25                  30        
 Arg Ala Leu Ala Gly Pro Asp Gln Gly Ile Thr Glu Ile Leu Met Asn
          35                  40                  45            
 Arg Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser Glu Leu
      50                  55                  60                
 Leu Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg Val Leu
  65                  70                  75                  80
 Leu Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala Asp Leu
                  85                  90                  95    
 Lys Glu Arg Glu Gln Met Ser Glu Ala Glu Val Gly Val Phe Val Gln
             100                 105                 110        
 Arg Leu Arg Gly Leu Met Asn Asp Ile Ala Ala Phe Pro Ala Pro Thr
         115                 120                 125            
 Ile Ala Ala Met Asp Gly Phe Ala Leu Gly Gly Gly Leu Glu Leu Ala
     130                 135                 140                
 Leu Ala Cys Asp Leu Arg Val Ala Ala Ser Ser Ala Val Met Gly Leu
 145                 150                 155                 160
 Ile Glu Thr Thr Arg Gly Leu Leu Pro Gly Ala Gly Gly Thr Gln Arg
                 165                 170                 175    
 Leu Pro Arg Cys Leu Gly Val Ala Leu Ala Lys Glu Leu Ile Phe Thr
             180                 185                 190        
 Gly Arg Arg Leu Ser Gly Thr Glu Ala His Val Leu Gly Leu Val Asn
         195                 200                 205            
 His Ala Val Ala Gln Asn Glu Glu Gly Asp Ala Ala Tyr Gln Arg Ala
     210                 215                 220                
 Arg Ala Leu Ala Gln Glu Ile Leu Pro Gln Ala Pro Ile Ala Val Arg
 225                 230                 235                 240
 Leu Gly Lys Val Ala Ile Asp Arg Gly Thr Glu Asn Ile Pro Thr Arg
                 245                 250                 255    
 Asp Arg Leu Glu Gly Met Ala Ala Phe Arg Glu Lys Arg Thr Pro Lys
             260                 265                 270        
 Phe Val Gly Lys
         275    



      <210> 261
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 261
 Met Leu Arg Val Leu Cys Leu Leu Arg Pro Trp Arg Pro Leu Arg Ala
   1               5                  10                  15    
 Arg Gly Cys Ala Ser Asp Gly Ala Ala Gly Gly Ser Glu Ile Gln Val
              20                  25                  30        
 Arg Ala Leu Ala Gly Pro Asp Gln Gly Ile Thr Glu Ile Leu Met Asn
          35                  40                  45            
 Arg Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser Glu Leu
      50                  55                  60                
 Leu Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg Val Leu
  65                  70                  75                  80
 Leu Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala Asp Leu
                  85                  90                  95    
 Lys Glu Arg Glu Gln Met Ser Glu Ala Glu Val Gly Val Phe Val Gln
             100                 105                 110        
 Arg Leu Arg Gly Leu Met Asn Asp Ile Ala Ser Ser Ala Val Met Gly
         115                 120                 125            
 Leu Ile Glu Thr Thr Arg Gly Leu Leu Pro Gly Ala Gly Gly Thr Gln
     130                 135                 140                
 Arg Leu Pro Arg Cys Leu Gly Val Ala Leu Ala Lys Glu Leu Ile Phe
 145                 150                 155                 160
 Thr Gly Arg Arg Leu Ser Gly Thr Glu Ala His Val Leu Gly Leu Val
                 165                 170                 175    
 Asn His Ala Val Ala Gln Asn Glu Glu Gly Asp Ala Ala Tyr Gln Arg
             180                 185                 190        
 Ala Arg Ala Leu Ala Gln Glu Ile Leu Pro Gln Ala Pro Ile Ala Val
         195                 200                 205            
 Arg Leu Gly Lys Val Ala Ile Asp Arg Gly Thr Glu Val Asp Ile Ala
     210                 215                 220                
 Ser Gly Met Ala Ile Glu Gly Met Cys Tyr Ala Gln Asn Ile Pro Thr
 225                 230                 235                 240
 Arg Asp Arg Leu Glu Gly Met Ala Ala Phe Arg Glu Lys Arg Thr Pro
                 245                 250                 255    
 Lys Phe Val Gly Lys
             260    



      <210> 262
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 262
 Met Arg Thr Ser Met Ser Glu Ala Ala Thr Arg Trp Ser Cys Gln Gly
   1               5                  10                  15    
 Ser Cys Gln Lys Thr Cys Phe Ser Arg Val Arg Pro Trp Arg Lys Arg
              20                  25                  30        
 Cys Asn Cys Gly Asp Ser Ser Ser Arg Arg Arg Arg Ser Cys Cys Thr
          35                  40                  45            
 Gly Ser Leu Gly Pro Met Pro Arg Leu Pro Ser Leu Trp Pro Leu Ser
      50                  55                  60                
 Leu Pro Leu Arg Ser Leu Ser Ser Pro His Arg Val Gln Gly Leu Gly
  65                  70                  75                  80
 Pro Pro Arg Arg Leu Lys Ser Gln Leu Leu Pro Arg Phe Phe Trp Arg
                  85                  90                  95    
 Arg Gln Gln Glu Pro Leu Ser Ser Phe Pro Gly Arg Asn Glu Gly Gly
             100                 105                 110        
 Ser Glu Met Glu Ile Leu Gly Val Cys Pro Val Ser Pro Gly Ala Leu
         115                 120                 125            
 Ser Tyr Met Glu Ser Pro Thr Gly Phe Trp Arg Pro Arg Glu Ala Ser
     130                 135                 140                
 Ser Leu Glu Leu Ala Lys Gly Ile Ser Lys Arg Arg His Phe Leu Pro
 145                 150                 155                 160
 Ala Pro Ala Leu Cys Pro Asn Pro Arg Ser Ser Glu Ala Phe Pro Gly
                 165                 170                 175    
 Ala Val Cys Val Thr Leu Ala Ile
             180                



      <210> 263
      <211> 292
      <212> PRT
      <213> Homo sapiens


      <400> 263
 Met Arg Ile Leu Leu Trp Ala Phe Trp Pro Ile Pro Ser Val Leu Pro
   1               5                  10                  15    
 Gly Trp His Arg Pro His Arg Thr Ser Arg Val Gly Leu Ser Gly Ser
              20                  25                  30        
 Ser Thr Ala Gly Pro Arg Asn Ser Arg Phe Gly Ala Ala Pro Ser Arg
          35                  40                  45            
 Leu Gly His Thr Gly Ala Arg Cys Arg Ser Pro Val Leu Arg His Leu
      50                  55                  60                
 Val Trp Asn Phe Arg Leu Ala Val Ser Ser Arg Ser Gly Ala Leu Cys
  65                  70                  75                  80
 Gly Val Phe Gly Gly Lys Arg Ala Leu Arg Arg Leu Thr Pro Ser Trp
                  85                  90                  95    
 Leu Cys Phe Arg Met Lys Thr Ile Leu Ser Asn Gln Thr Val Asp Ile
             100                 105                 110        
 Pro Glu Asn Val Asp Ile Thr Leu Lys Gly Arg Thr Val Ile Val Lys
         115                 120                 125            
 Gly Pro Arg Gly Thr Leu Arg Arg Asp Phe Asn His Ile Asn Val Glu
     130                 135                 140                
 Leu Ser Leu Leu Gly Lys Lys Lys Lys Arg Leu Arg Val Asp Lys Trp
 145                 150                 155                 160
 Trp Gly Asn Arg Lys Glu Leu Ala Thr Val Arg Thr Ile Cys Ser His
                 165                 170                 175    
 Val Gln Asn Met Ile Lys Gly Val Thr Leu Gly Phe Arg Tyr Lys Met
             180                 185                 190        
 Arg Ser Val Tyr Ala His Phe Pro Ile Asn Val Val Ile Gln Glu Asn
         195                 200                 205            
 Gly Ser Leu Val Glu Ile Arg Asn Phe Leu Gly Glu Lys Tyr Ile Arg
     210                 215                 220                
 Arg Val Arg Met Arg Pro Gly Val Ala Cys Ser Val Ser Gln Ala Gln
 225                 230                 235                 240
 Lys Asp Glu Leu Ile Leu Glu Gly Asn Asp Ile Glu Leu Val Ser Asn
                 245                 250                 255    
 Ser Ala Ala Leu Ile Gln Gln Ala Thr Thr Val Lys Asn Lys Asp Ile
             260                 265                 270        
 Arg Lys Phe Leu Asp Gly Ile Tyr Val Ser Glu Lys Gly Thr Val Gln
         275                 280                 285            
 Gln Ala Asp Glu
     290        



      <210> 264
      <211> 29
      <212> PRT
      <213> Homo sapiens


      <400> 264
 Met Ala Ala Ile Pro Ala Leu Trp Glu Ala Lys Val Gly Arg Ser Leu
   1               5                  10                  15    
 Glu Met Lys Ser Leu Arg Pro Pro Trp Thr Lys Trp
              20                  25            



      <210> 265
      <211> 103
      <212> PRT
      <213> Homo sapiens


      <400> 265
 Met Thr Ala Arg Gly Lys Thr Ser Asp Ile Glu Ala Asn Gln Pro Leu
   1               5                  10                  15    
 Glu Thr Asn Lys Glu Asn Ser Ser Ser Val Thr Val Ser Asp Pro Glu
              20                  25                  30        
 Met Glu Asn Lys Ala Gly Gln Thr Leu Glu Asn Ser Ser Leu Met Ala
          35                  40                  45            
 Glu Leu Leu Ser Asp Val Pro Phe Thr Leu Ala Pro His Val Leu Ala
      50                  55                  60                
 Val Gln Gly Thr Ile Thr Asp Leu Pro Asp His Leu Leu Ser Tyr Asp
  65                  70                  75                  80
 Gly Ser Glu Asn Leu Ser Arg Phe Trp Tyr Asp Phe Thr Leu Glu Asn
                  85                  90                  95    
 Ser Val Leu Cys Asp Ser
             100        



      <210> 266
      <211> 991
      <212> PRT
      <213> Homo sapiens


      <400> 266
 Met Val Val Ser Ala Gly Pro Leu Ser Gly Glu Lys Ala Ala Ile Asn
   1               5                  10                  15    
 Ile Leu Glu Ile Asn Glu Lys Leu Arg Pro Gln Leu Ala Glu Lys Lys
              20                  25                  30        
 Gln Gln Phe Arg Asn Leu Lys Glu Arg Cys Phe Leu Thr Gln Leu Ala
          35                  40                  45            
 Gly Phe Leu Ala Asn Gln Gln Asn Lys Tyr Lys Tyr Glu Glu Cys Lys
      50                  55                  60                
 Asp Leu Ile Lys Phe Met Leu Arg Asn Glu Arg Gln Phe Lys Glu Glu
  65                  70                  75                  80
 Lys Leu Ala Glu Gln Leu Lys Gln Ala Glu Glu Leu Arg Gln Tyr Lys
                  85                  90                  95    
 Val Leu Val His Ala Gln Glu Arg Glu Leu Thr Gln Leu Arg Glu Lys
             100                 105                 110        
 Leu Arg Glu Gly Arg Asp Ala Ser Arg Ser Leu Asn Glu His Leu Gln
         115                 120                 125            
 Ala Leu Leu Thr Pro Asp Glu Pro Asp Lys Ser Gln Gly Gln Asp Leu
     130                 135                 140                
 Gln Glu Gln Leu Ala Glu Gly Cys Arg Leu Ala Gln His Leu Val Gln
 145                 150                 155                 160
 Lys Leu Ser Pro Glu Asn Asp Asn Asp Asp Asp Glu Asp Val Gln Val
                 165                 170                 175    
 Glu Val Ala Glu Lys Val Gln Lys Ser Ser Ala Pro Arg Glu Met Gln
             180                 185                 190        
 Lys Ala Glu Glu Lys Glu Val Pro Glu Asp Ser Leu Glu Glu Cys Ala
         195                 200                 205            
 Ile Thr Cys Ser Asn Ser His Gly Pro Tyr Asp Ser Asn Gln Pro His
     210                 215                 220                
 Lys Lys Thr Lys Ile Thr Phe Glu Glu Asp Lys Val Asp Ser Thr Leu
 225                 230                 235                 240
 Ile Gly Ser Ser Ser His Val Glu Trp Glu Asp Ala Val His Ile Ile
                 245                 250                 255    
 Pro Glu Asn Glu Ser Asp Asp Glu Glu Glu Glu Glu Lys Gly Pro Val
             260                 265                 270        
 Ser Pro Arg Asn Leu Gln Glu Ser Glu Glu Glu Glu Val Pro Gln Glu
         275                 280                 285            
 Ser Trp Asp Glu Gly Tyr Ser Thr Leu Ser Ile Pro Pro Glu Met Leu
     290                 295                 300                
 Ala Ser Tyr Gln Ser Tyr Ser Ser Thr Phe His Ser Leu Glu Glu Gln
 305                 310                 315                 320
 Gln Val Cys Met Ala Val Asp Ile Gly Arg His Arg Trp Asp Gln Val
                 325                 330                 335    
 Lys Lys Glu Asp His Glu Ala Thr Gly Pro Arg Leu Ser Arg Glu Leu
             340                 345                 350        
 Leu Asp Glu Lys Gly Pro Glu Val Leu Gln Asp Ser Leu Asp Arg Cys
         355                 360                 365            
 Tyr Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr Asp Ser Cys Gln Pro
     370                 375                 380                
 Tyr Arg Ser Ala Phe Tyr Val Leu Glu Gln Gln Arg Val Gly Leu Ala
 385                 390                 395                 400
 Val Asn Met Asp Glu Ile Glu Lys Tyr Gln Glu Val Glu Glu Asp Gln
                 405                 410                 415    
 Asp Pro Ser Cys Pro Arg Leu Ser Arg Glu Leu Leu Asp Glu Lys Glu
             420                 425                 430        
 Pro Glu Val Leu Gln Asp Ser Leu Gly Arg Cys Tyr Ser Thr Pro Ser
         435                 440                 445            
 Gly Tyr Leu Glu Leu Pro Asp Leu Gly Gln Pro Tyr Ser Ser Ala Val
     450                 455                 460                
 Tyr Ser Leu Glu Glu Gln Tyr Leu Gly Leu Ala Leu Asp Val Asp Arg
 465                 470                 475                 480
 Ile Lys Lys Asp Gln Glu Glu Glu Glu Asp Gln Gly Pro Pro Cys Pro
                 485                 490                 495    
 Arg Leu Ser Arg Glu Leu Leu Glu Val Val Glu Pro Glu Val Leu Gln
             500                 505                 510        
 Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Ser Cys Leu Glu Gln
         515                 520                 525            
 Pro Asp Ser Cys Gln Pro Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu
     530                 535                 540                
 Lys His Val Gly Phe Ser Leu Asp Val Gly Glu Ile Glu Lys Lys Gly
 545                 550                 555                 560
 Lys Gly Lys Lys Arg Arg Gly Arg Arg Ser Lys Lys Glu Arg Arg Arg
                 565                 570                 575    
 Gly Arg Lys Glu Gly Glu Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu
             580                 585                 590        
 Ser Arg Glu Leu Leu Asp Glu Lys Gly Pro Glu Val Leu Gln Asp Ser
         595                 600                 605            
 Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr Asp
     610                 615                 620                
 Ser Cys Gln Pro Tyr Arg Ser Ala Phe Tyr Ile Leu Glu Gln Gln Arg
 625                 630                 635                 640
 Val Gly Leu Ala Val Asp Met Asp Glu Ile Glu Lys Tyr Gln Glu Val
                 645                 650                 655    
 Glu Glu Asp Gln Asp Pro Ser Cys Pro Arg Leu Ser Gly Glu Leu Leu
             660                 665                 670        
 Asp Glu Lys Glu Pro Glu Val Leu Gln Glu Ser Leu Asp Arg Cys Tyr
         675                 680                 685            
 Ser Thr Pro Ser Gly Cys Leu Glu Leu Thr Asp Ser Cys Gln Pro Tyr
     690                 695                 700                
 Arg Ser Ala Phe Tyr Ile Leu Glu Gln Gln Arg Val Gly Leu Ala Val
 705                 710                 715                 720
 Asp Met Asp Glu Ile Glu Lys Tyr Gln Glu Val Glu Glu Asp Gln Asp
                 725                 730                 735    
 Pro Ser Cys Pro Arg Leu Ser Arg Glu Leu Leu Ala Glu Lys Glu Pro
             740                 745                 750        
 Glu Val Leu Gln Asp Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Gly
         755                 760                 765            
 Tyr Leu Glu Leu Pro Asp Leu Gly Gln Pro Tyr Ser Ser Ala Val Tyr
     770                 775                 780                
 Ser Leu Glu Glu Gln Tyr Leu Gly Leu Ala Leu Asp Val Asp Arg Ile
 785                 790                 795                 800
 Lys Lys Asp Gln Glu Glu Glu Glu Asp Gln Gly Pro Pro Cys Pro Arg
                 805                 810                 815    
 Leu Ser Arg Glu Leu Leu Glu Val Val Glu Pro Glu Val Leu Gln Asp
             820                 825                 830        
 Ser Leu Asp Arg Cys Tyr Ser Thr Pro Ser Ser Cys Leu Glu Gln Pro
         835                 840                 845            
 Asp Ser Cys Gln Pro Tyr Gly Ser Ser Phe Tyr Ala Leu Glu Glu Lys
     850                 855                 860                
 His Val Gly Phe Ser Leu Asp Val Gly Glu Ile Glu Lys Lys Gly Lys
 865                 870                 875                 880
 Gly Lys Lys Arg Arg Gly Arg Arg Ser Lys Lys Glu Arg Arg Arg Gly
                 885                 890                 895    
 Arg Lys Glu Gly Glu Glu Asp Gln Asn Pro Pro Cys Pro Arg Leu Asn
             900                 905                 910        
 Ser Met Leu Met Glu Val Glu Glu Pro Glu Val Leu Gln Asp Ser Leu
         915                 920                 925            
 Asp Ile Cys Tyr Ser Thr Pro Ser Met Tyr Phe Glu Leu Pro Asp Ser
     930                 935                 940                
 Phe Gln His Tyr Arg Ser Val Phe Tyr Ser Phe Glu Glu Glu His Ile
 945                 950                 955                 960
 Ser Phe Ala Leu Tyr Val Asp Asn Arg Phe Phe Thr Leu Thr Val Thr
                 965                 970                 975    
 Ser Leu His Leu Val Phe Gln Met Gly Val Ile Phe Pro Gln
             980                 985                 990



      <210> 267
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 267
 Met Lys Leu Asn Ile Ser Phe Pro Ala Thr Gly Cys Gln Lys Leu Ile
   1               5                  10                  15    
 Glu Val Asp Asp Glu Arg Lys Leu Arg Thr Phe Tyr Glu Lys Arg Met
              20                  25                  30        
 Ala Thr Glu Val Ala Ala Asp Ala Leu Gly Glu Glu Trp Lys Gly Tyr
          35                  40                  45            
 Val Val Arg Ile Ser Gly Gly Asn Asp Lys Gln Gly Phe Pro Met Lys
      50                  55                  60                
 Gln Gly Val Leu Thr His Gly Arg Val Arg Leu Leu Leu Ser Lys Gly
  65                  70                  75                  80
 His Ser Cys Tyr Arg Pro Arg Arg Thr Gly Glu Arg Lys Arg Lys Ser
                  85                  90                  95    
 Val Arg Gly Cys Ile Val Asp Ala Asn Leu Ser Val Leu Asn Leu Val
             100                 105                 110        
 Ile Val Lys Lys Gly Glu Lys Asp Ile Pro Gly Leu Thr Asp Thr Thr
         115                 120                 125            
 Val Pro Arg Arg Leu Gly Pro Gln Lys Ser
     130                 135            



      <210> 268
      <211> 199
      <212> PRT
      <213> Homo sapiens


      <400> 268
 Met Ser Phe Ile Phe Glu Trp Ile Tyr Asn Gly Phe Ser Ser Val Leu
   1               5                  10                  15    
 Gln Phe Leu Gly Leu Tyr Lys Lys Ser Gly Lys Leu Val Phe Leu Gly
              20                  25                  30        
 Leu Asp Asn Ala Gly Lys Thr Thr Leu Leu His Met Leu Lys Asp Asp
          35                  40                  45            
 Arg Leu Gly Gln His Val Pro Thr Leu His Pro Thr Ser Glu Glu Leu
      50                  55                  60                
 Thr Ile Ala Gly Met Thr Phe Thr Thr Phe Asp Leu Gly Gly His Glu
  65                  70                  75                  80
 Gln Ala Arg Arg Val Trp Lys Asn Tyr Leu Pro Ala Ile Asn Gly Ile
                  85                  90                  95    
 Val Phe Leu Val Asp Cys Ala Asp His Ser Arg Leu Val Glu Ser Lys
             100                 105                 110        
 Val Glu Leu Asn Ala Leu Met Thr Asp Glu Thr Ile Ser Asn Val Pro
         115                 120                 125            
 Ile Leu Ile Leu Gly Asn Lys Ile Asp Arg Thr Asp Ala Ile Ser Glu
     130                 135                 140                
 Glu Lys Leu Arg Glu Ile Phe Gly Leu Tyr Gly Gln Thr Thr Gly Lys
 145                 150                 155                 160
 Gly Asn Val Thr Leu Lys Glu Leu Asn Ala Arg Pro Met Glu Val Phe
                 165                 170                 175    
 Met Cys Ser Val Leu Lys Arg Gln Gly Tyr Gly Glu Gly Phe Arg Trp
             180                 185                 190        
 Leu Ser Gln Tyr Ile Asp
         195            



      <210> 269
      <211> 1049
      <212> PRT
      <213> Homo sapiens


      <400> 269
 Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg
   1               5                  10                  15    
 Trp Gly Pro Arg Arg Arg Pro Pro Leu Val Pro Leu Leu Leu Leu Leu
              20                  25                  30        
 Val Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala
          35                  40                  45            
 Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val
      50                  55                  60                
 Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala
  65                  70                  75                  80
 Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val
                  85                  90                  95    
 Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu
             100                 105                 110        
 Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser
         115                 120                 125            
 Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala
     130                 135                 140                
 Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr
 145                 150                 155                 160
 Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys
                 165                 170                 175    
 Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys
             180                 185                 190        
 Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly
         195                 200                 205            
 Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro
     210                 215                 220                
 Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln
 225                 230                 235                 240
 Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly
                 245                 250                 255    
 Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu
             260                 265                 270        
 Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp
         275                 280                 285            
 Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr
     290                 295                 300                
 Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu
 305                 310                 315                 320
 Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn
                 325                 330                 335    
 Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp
             340                 345                 350        
 Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr
         355                 360                 365            
 Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr
     370                 375                 380                
 Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly
 385                 390                 395                 400
 Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe
                 405                 410                 415    
 Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro
             420                 425                 430        
 Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala
         435                 440                 445            
 Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg
     450                 455                 460                
 Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly
 465                 470                 475                 480
 Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser
                 485                 490                 495    
 Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser
             500                 505                 510        
 Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys
         515                 520                 525            
 Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val
     530                 535                 540                
 Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala
 545                 550                 555                 560
 Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile
                 565                 570                 575    
 Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg
             580                 585                 590        
 Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu
         595                 600                 605            
 Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg
     610                 615                 620                
 Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln
 625                 630                 635                 640
 Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln
                 645                 650                 655    
 Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn
             660                 665                 670        
 Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala
         675                 680                 685            
 Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser
     690                 695                 700                
 Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr
 705                 710                 715                 720
 Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro
                 725                 730                 735    
 Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro
             740                 745                 750        
 His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu
         755                 760                 765            
 Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu
     770                 775                 780                
 Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro
 785                 790                 795                 800
 Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro
                 805                 810                 815    
 Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu
             820                 825                 830        
 Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser
         835                 840                 845            
 Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val
     850                 855                 860                
 Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu
 865                 870                 875                 880
 Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala
                 885                 890                 895    
 Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro
             900                 905                 910        
 Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln
         915                 920                 925            
 Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr
     930                 935                 940                
 Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val
 945                 950                 955                 960
 Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro
                 965                 970                 975    
 Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu
             980                 985                 990        
 Gly Ser Tyr Gly Val Pro Leu Trp Ile Ile Ile Leu Ala Ile Leu Phe
         995                1000                1005            
 Gly Leu Leu Leu Leu Gly Leu Leu Ile Tyr Ile Leu Tyr Lys Leu Gly
    1010                1015                1020                
 Phe Phe Lys Arg Ser Leu Pro Tyr Gly Thr Ala Met Glu Lys Ala Gln
1025                1030                1035                1040
 Leu Lys Pro Pro Ala Thr Ser Asp Ala
                1045                



      <210> 270
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 270
 Met Gly Arg Arg Leu Lys Gly Ala Arg Arg Leu Lys Leu Ser Pro Leu
   1               5                  10                  15    
 Arg Ser Leu Arg Lys Gly Pro Gly Leu Leu Ser Pro Pro Ser Ala Ser
              20                  25                  30        
 Pro Val Pro Thr Pro Ala Val Ser Arg Thr Leu Leu Gly Asn Phe Glu
          35                  40                  45            
 Glu Ser Leu Leu Arg Gly Arg Phe Ala Pro Ser Gly His Ile Glu Gly
      50                  55                  60                
 Phe Thr Ala Glu Ile Gly Ala Ser Gly Ser Tyr Cys Pro Gln His Val
  65                  70                  75                  80
 Thr Leu Pro Val Thr Val Thr Phe Phe Asp Val Ser Glu Gln Asn Ala
                  85                  90                  95    
 Pro Ala Pro Phe Leu Gly Ile Val Asp Leu Asn Pro Leu Gly Arg Lys
             100                 105                 110        
 Gly Tyr Ser Val Pro Lys Val Gly Thr Val Gln Val Thr Leu Phe Asn
         115                 120                 125            
 Pro Asn Gln Thr Val Val Lys Met Phe Leu Val Thr Phe Asp Phe Ser
     130                 135                 140                
 Asp Met Pro Ala Ala His Met Thr Phe Leu Arg His Arg Leu Phe Leu
 145                 150                 155                 160
 Val Pro Val Gly Glu Glu Gly Asn Ala Asn Pro Thr His Arg Leu Leu
                 165                 170                 175    
 Cys Tyr Leu Leu His Leu Arg Phe Arg Ser Ser Arg Ser Gly Arg Leu
             180                 185                 190        
 Ser Leu His Gly Asp Ile Arg Leu Leu Phe Ser Arg Arg Ser Leu Glu
         195                 200                 205            
 Leu Asp Thr Gly Leu Pro Tyr Glu Leu Gln Ala Val Thr Glu Ala Pro
     210                 215                 220                
 His Asn Pro Arg Tyr Ser Pro Leu Pro
 225                 230            



      <210> 271
      <211> 394
      <212> PRT
      <213> Homo sapiens


      <400> 271
 Met Glu Gln Cys Ala Cys Val Glu Arg Glu Leu Asp Lys Val Leu Gln
   1               5                  10                  15    
 Lys Phe Leu Thr Tyr Gly Gln His Cys Glu Arg Ser Leu Glu Glu Leu
              20                  25                  30        
 Leu His Tyr Val Gly Gln Leu Arg Ala Glu Leu Ala Ser Ala Ala Leu
          35                  40                  45            
 Gln Gly Thr Pro Leu Ser Ala Thr Leu Ser Leu Val Met Ser Gln Cys
      50                  55                  60                
 Cys Arg Lys Ile Lys Asp Thr Val Gln Lys Leu Ala Ser Asp His Lys
  65                  70                  75                  80
 Asp Ile His Ser Ser Val Ser Arg Val Gly Lys Ala Ile Asp Arg Asn
                  85                  90                  95    
 Phe Asp Ser Glu Ile Cys Gly Val Val Ser Asp Ala Val Trp Asp Ala
             100                 105                 110        
 Arg Glu Gln Gln Gln Gln Ile Leu Gln Met Ala Ile Val Glu His Leu
         115                 120                 125            
 Tyr Gln Gln Gly Met Leu Ser Val Ala Glu Glu Leu Cys Gln Glu Ser
     130                 135                 140                
 Thr Leu Asn Val Asp Leu Asp Phe Lys Gln Pro Phe Leu Glu Leu Asn
 145                 150                 155                 160
 Arg Ile Leu Glu Ala Leu His Glu Gln Asp Leu Gly Pro Ala Leu Glu
                 165                 170                 175    
 Trp Ala Val Ser His Arg Gln Arg Leu Leu Glu Leu Asn Ser Ser Leu
             180                 185                 190        
 Glu Phe Lys Leu His Arg Leu His Phe Ile Arg Leu Leu Ala Gly Gly
         195                 200                 205            
 Pro Ala Lys Gln Leu Glu Ala Leu Ser Tyr Ala Arg His Phe Gln Pro
     210                 215                 220                
 Phe Ala Arg Leu His Gln Arg Glu Ile Gln Val Met Met Gly Ser Leu
 225                 230                 235                 240
 Val Tyr Leu Arg Leu Gly Leu Glu Lys Ser Pro Tyr Cys His Leu Leu
                 245                 250                 255    
 Asp Ser Ser His Trp Ala Glu Ile Cys Glu Thr Phe Thr Arg Asp Ala
             260                 265                 270        
 Cys Ser Leu Leu Gly Leu Ser Val Glu Ser Pro Leu Ser Val Ser Phe
         275                 280                 285            
 Ala Ser Gly Cys Val Ala Leu Pro Val Leu Met Asn Ile Lys Ala Val
     290                 295                 300                
 Ile Glu Gln Arg Gln Cys Thr Gly Val Trp Asn His Lys Asp Glu Leu
 305                 310                 315                 320
 Pro Ile Glu Ile Glu Leu Gly Met Lys Cys Trp Tyr His Ser Val Phe
                 325                 330                 335    
 Ala Cys Pro Ile Leu Arg Gln Gln Thr Ser Asp Ser Asn Pro Pro Ile
             340                 345                 350        
 Lys Leu Ile Cys Gly His Val Ile Ser Arg Asp Ala Leu Asn Lys Leu
         355                 360                 365            
 Ile Asn Gly Gly Lys Leu Lys Cys Pro Tyr Cys Pro Met Glu Gln Asn
     370                 375                 380                
 Pro Ala Asp Gly Lys Arg Ile Ile Phe
 385                 390            



      <210> 272
      <211> 454
      <212> PRT
      <213> Homo sapiens


      <400> 272
 Met Ser Ile Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln Ile Gly
   1               5                  10                  15    
 Phe Glu Val Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser Gln Gly
              20                  25                  30        
 Leu Cys Ser Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys Lys Glu
          35                  40                  45            
 Arg Phe Phe Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg Ala Val
      50                  55                  60                
 Leu Val Asp Met Glu Pro Lys Val Ile Asn Gln Thr Leu Ser Lys Ala
  65                  70                  75                  80
 Ala Gln Ser Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe Cys Gln
                  85                  90                  95    
 Lys Gln Gly Ser Gly Asn Asn Trp Ala Tyr Gly Tyr Ser Val His Gly
             100                 105                 110        
 Pro Arg His Glu Glu Ser Ile Met Asn Ile Ile Arg Lys Glu Val Glu
         115                 120                 125            
 Lys Cys Asp Ser Phe Ser Gly Phe Phe Ile Ile Met Ser Met Ala Gly
     130                 135                 140                
 Gly Thr Gly Ser Gly Leu Gly Ala Phe Val Thr Gln Asn Leu Glu Asp
 145                 150                 155                 160
 Gln Tyr Ser Asn Ser Leu Lys Met Asn Gln Ile Ile Trp Pro Tyr Gly
                 165                 170                 175    
 Thr Gly Glu Val Ile Val Gln Asn Tyr Asn Ser Ile Leu Thr Leu Ser
             180                 185                 190        
 His Leu Tyr Arg Ser Ser Asp Ala Leu Leu Leu His Glu Asn Asp Ala
         195                 200                 205            
 Ile His Lys Ile Cys Ala Lys Leu Met Asn Ile Lys Gln Ile Ser Phe
     210                 215                 220                
 Ser Asp Ile Asn Gln Val Leu Ala His Gln Leu Gly Ser Val Phe Gln
 225                 230                 235                 240
 Pro Thr Tyr Ser Ala Glu Ser Ser Phe His Tyr Arg Arg Asn Pro Leu
                 245                 250                 255    
 Gly Asp Leu Met Glu His Leu Val Pro His Pro Glu Phe Lys Met Leu
             260                 265                 270        
 Ser Val Arg Asn Ile Pro His Met Ser Glu Asn Ser Leu Ala Tyr Thr
         275                 280                 285            
 Thr Phe Thr Trp Ala Gly Leu Leu Lys His Leu Arg Gln Met Leu Ile
     290                 295                 300                
 Ser Asn Ala Lys Met Glu Glu Gly Ile Asp Arg His Val Trp Pro Pro
 305                 310                 315                 320
 Leu Ser Gly Leu Pro Pro Leu Ser Lys Met Ser Leu Asn Lys Asp Leu
                 325                 330                 335    
 His Phe Asn Thr Ser Ile Ala Asn Leu Val Ile Leu Arg Gly Lys Asp
             340                 345                 350        
 Val Gln Ser Ala Asp Val Glu Gly Phe Lys Asp Pro Ala Leu Tyr Thr
         355                 360                 365            
 Ser Trp Leu Lys Pro Val Asn Ala Phe Asn Val Trp Lys Thr Gln Arg
     370                 375                 380                
 Ala Phe Ser Lys Tyr Glu Lys Ser Ala Val Leu Val Ser Asn Ser Gln
 385                 390                 395                 400
 Phe Leu Val Lys Pro Leu Asp Met Ile Val Gly Lys Ala Trp Asn Met
                 405                 410                 415    
 Phe Ala Ser Lys Ala Tyr Ile His Gln Tyr Thr Lys Phe Gly Ile Glu
             420                 425                 430        
 Glu Glu Asp Phe Leu Asp Ser Phe Thr Ser Leu Glu Gln Val Val Ala
         435                 440                 445            
 Ser Tyr Cys Asn Leu
     450            



      <210> 273
      <211> 352
      <212> PRT
      <213> Homo sapiens


      <400> 273
 Met Ser Ile Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln Ile Gly
   1               5                  10                  15    
 Phe Glu Val Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser Gln Gly
              20                  25                  30        
 Leu Cys Ser Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys Lys Glu
          35                  40                  45            
 Arg Phe Phe Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg Ala Val
      50                  55                  60                
 Leu Val Asp Met Glu Pro Lys Val Ile Asn Gln Thr Leu Ser Lys Ala
  65                  70                  75                  80
 Ala Gln Ser Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe Cys Gln
                  85                  90                  95    
 Lys Gln Gly Ser Gly Asn Asn Trp Ala Tyr Gly Tyr Ser Val His Gly
             100                 105                 110        
 Pro Arg His Glu Glu Ser Ile Met Asn Ile Ile Arg Lys Glu Val Glu
         115                 120                 125            
 Lys Cys Asp Ser Phe Ser Gly Phe Phe Ile Ile Met Ser Met Ala Gly
     130                 135                 140                
 Gly Thr Gly Ser Gly Leu Gly Ala Phe Val Thr Gln Asn Leu Glu Asp
 145                 150                 155                 160
 Gln Tyr Ser Asn Ser Leu Lys Met Asn Gln Ile Ile Trp Pro Tyr Gly
                 165                 170                 175    
 Thr Gly Glu Val Ile Val Gln Asn Tyr Asn Ser Ile Leu Thr Leu Ser
             180                 185                 190        
 His Leu Tyr Arg Ser Ser Asp Ala Leu Leu Leu His Glu Asn Asp Ala
         195                 200                 205            
 Ile His Lys Ile Cys Ala Lys Leu Met Asn Ile Lys Gln Ile Ser Phe
     210                 215                 220                
 Ser Asp Ile Asn Gln Val Leu Ala His Gln Leu Gly Ser Val Phe Gln
 225                 230                 235                 240
 Pro Thr Tyr Ser Ala Glu Ser Ser Phe His Tyr Arg Arg Asn Pro Leu
                 245                 250                 255    
 Glu Gly Phe Lys Asp Pro Ala Leu Tyr Thr Ser Trp Leu Lys Pro Val
             260                 265                 270        
 Asn Ala Phe Asn Val Trp Lys Thr Gln Arg Ala Phe Ser Lys Tyr Glu
         275                 280                 285            
 Lys Ser Ala Val Leu Val Ser Asn Ser Gln Phe Leu Val Lys Pro Leu
     290                 295                 300                
 Asp Met Ile Val Gly Lys Ala Trp Asn Met Phe Ala Ser Lys Ala Tyr
 305                 310                 315                 320
 Ile His Gln Tyr Thr Lys Phe Gly Ile Glu Glu Glu Asp Phe Leu Asp
                 325                 330                 335    
 Ser Phe Thr Ser Leu Glu Gln Val Val Ala Ser Tyr Cys Asn Leu
             340                 345                 350    



      <210> 274
      <211> 329
      <212> PRT
      <213> Homo sapiens


      <400> 274
 Met Glu Ile Val Trp Glu Val Leu Phe Leu Leu Gln Ala Asn Phe Ile
   1               5                  10                  15    
 Val Cys Ile Ser Ala Gln Gln Asn Ser Pro Lys Ile His Glu Gly Trp
              20                  25                  30        
 Trp Ala Tyr Lys Glu Val Val Gln Gly Ser Phe Val Pro Val Pro Ser
          35                  40                  45            
 Phe Trp Gly Leu Val Asn Ser Ala Trp Asn Leu Cys Ser Val Gly Lys
      50                  55                  60                
 Arg Gln Ser Pro Val Asn Ile Glu Thr Ser His Met Ile Phe Asp Pro
  65                  70                  75                  80
 Phe Leu Thr Pro Leu Arg Ile Asn Thr Gly Gly Arg Lys Val Ser Gly
                  85                  90                  95    
 Thr Met Tyr Asn Thr Gly Arg His Val Ser Leu Arg Leu Asp Lys Glu
             100                 105                 110        
 His Leu Val Asn Ile Ser Gly Gly Pro Met Thr Tyr Ser His Arg Leu
         115                 120                 125            
 Glu Glu Ile Arg Leu His Phe Gly Ser Glu Asp Ser Gln Gly Ser Glu
     130                 135                 140                
 His Leu Leu Asn Gly Gln Ala Phe Ser Gly Glu Val Gln Leu Ile His
 145                 150                 155                 160
 Tyr Asn His Glu Leu Tyr Thr Asn Val Thr Glu Ala Ala Lys Ser Pro
                 165                 170                 175    
 Asn Gly Leu Val Val Val Ser Ile Phe Ile Lys Val Ser Asp Ser Ser
             180                 185                 190        
 Asn Pro Phe Leu Asn Arg Met Leu Asn Arg Asp Thr Ile Thr Arg Ile
         195                 200                 205            
 Thr Tyr Lys Asn Asp Ala Tyr Leu Leu Gln Gly Leu Asn Ile Glu Glu
     210                 215                 220                
 Leu Tyr Pro Glu Thr Ser Ser Phe Ile Thr Tyr Asp Gly Ser Met Thr
 225                 230                 235                 240
 Ile Pro Pro Cys Tyr Glu Thr Ala Ser Trp Ile Ile Met Asn Lys Pro
                 245                 250                 255    
 Val Tyr Ile Thr Arg Met Gln Met His Ser Leu Arg Leu Leu Ser Gln
             260                 265                 270        
 Asn Gln Pro Ser Gln Ile Phe Leu Ser Met Ser Asp Asn Phe Arg Pro
         275                 280                 285            
 Val Gln Pro Leu Asn Asn Arg Cys Ile Arg Thr Asn Ile Asn Phe Ser
     290                 295                 300                
 Leu Gln Gly Lys Asp Cys Pro Asn Asn Arg Ala Gln Lys Leu Gln Tyr
 305                 310                 315                 320
 Arg Val Asn Glu Trp Leu Leu Lys
                 325            



      <210> 275
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 275
 Met Trp Gly Gly Met Cys Val Tyr Ile Tyr Ile His Phe Gln Trp Met
   1               5                  10                  15    
 Glu Ile Cys Ile Tyr Thr Phe Ser Val Tyr Tyr Ile Tyr Met His Thr
              20                  25                  30        
 Leu Cys Met Tyr Val Asp Val Tyr Leu His Thr Leu Lys Asp Ile Tyr
          35                  40                  45            
 Leu His Thr Ile Gln Cys Met Tyr Asp Thr Phe Gly Tyr Tyr Ile Leu
      50                  55                  60                
 Leu Lys Phe Pro Val Ala Thr Tyr Asp Leu Ile Ser Leu Thr Ser Tyr
  65                  70                  75                  80
 Ser Ser Phe Lys His Pro Ser Tyr Met
                  85                



      <210> 276
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 276
 Met Ala Ala Gln Cys Val Arg Leu Ala Arg Arg Ser Leu Pro Ala Leu
   1               5                  10                  15    
 Ala Leu Ser Leu Arg Pro Ser Pro Arg Leu Leu Cys Thr Ala Thr Lys
              20                  25                  30        
 Gln Lys Asn Ser Gly Gln Asn Leu Glu Glu Asp Met Gly Gln Ser Glu
          35                  40                  45            
 Gln Lys Ala Asp Pro Pro Ala Thr Glu Lys Thr Leu Leu Glu Glu Lys
      50                  55                  60                
 Val Lys Leu Glu Glu Gln Leu Lys Glu Thr Val Glu Lys Tyr Lys Arg
  65                  70                  75                  80
 Ala Leu Ala Asp Thr Glu Asn Leu Arg Gln Arg Ser Gln Lys Leu Val
                  85                  90                  95    
 Glu Glu Ala Lys Leu Tyr Gly Ile Gln Ala Phe Cys Lys Asp Leu Leu
             100                 105                 110        
 Glu Val Ala Asp Val Leu Glu Lys Ala Thr Gln Cys Val Pro Lys Glu
         115                 120                 125            
 Glu Ile Lys Asp Asp Asn Pro His Leu Lys Asn Leu Tyr Glu Gly Leu
     130                 135                 140                
 Val Met Thr Glu Val Gln Ile Gln Lys Val Phe Thr Lys His Gly Leu
 145                 150                 155                 160
 Leu Lys Leu Asn Pro Val Gly Ala Lys Phe Asp Pro Tyr Glu His Glu
                 165                 170                 175    
 Ala Leu Phe His Thr Pro Val Glu Gly Lys Glu Pro Gly Thr Val Ala
             180                 185                 190        
 Leu Val Ser Lys Val Gly Tyr Lys Leu His Gly Arg Thr Leu Arg Pro
         195                 200                 205            
 Ala Leu Val Gly Val Val Lys Glu Ala
     210                 215        



      <210> 277
      <211> 61
      <212> PRT
      <213> Homo sapiens


      <400> 277
 Met Gly Ser His His Val Thr Gln Ala Gly Leu Lys Leu Leu Gly Thr
   1               5                  10                  15    
 Ser Asn Pro Pro Ala Phe Ala Ser Arg Ser Ala Gly Ile Thr Asp Val
              20                  25                  30        
 Ser His Tyr Pro Ser Gln Lys Leu Thr Phe Ser Lys Ala Thr Thr Lys
          35                  40                  45            
 Lys Thr Pro Gln Ile Cys Gln Ser Met Lys Val Ser
      50                  55                  60



      <210> 278
      <211> 518
      <212> PRT
      <213> Homo sapiens


      <400> 278
 Met Phe Leu Leu Phe Leu Leu Thr Cys Glu Leu Ala Ala Glu Val Ala
   1               5                  10                  15    
 Ala Glu Val Glu Lys Ser Ser Asp Gly Pro Gly Ala Ala Gln Glu Pro
              20                  25                  30        
 Thr Trp Leu Thr Asp Val Pro Ala Ala Met Glu Phe Ile Ala Ala Thr
          35                  40                  45            
 Glu Val Ala Val Ile Gly Phe Phe Gln Asp Leu Glu Ile Pro Ala Val
      50                  55                  60                
 Pro Ile Leu His Ser Met Val Gln Lys Phe Pro Gly Val Ser Phe Gly
  65                  70                  75                  80
 Ile Ser Thr Asp Ser Glu Val Leu Thr His Tyr Asn Ile Thr Gly Asn
                  85                  90                  95    
 Thr Ile Cys Leu Phe Arg Leu Val Asp Asn Glu Gln Leu Asn Leu Glu
             100                 105                 110        
 Asp Glu Asp Ile Glu Ser Ile Asp Ala Thr Lys Leu Ser Arg Phe Ile
         115                 120                 125            
 Glu Ile Asn Ser Leu His Met Val Thr Glu Tyr Asn Pro Val Gly Gly
     130                 135                 140                
 Lys Glu Gly Ser Thr Gln Leu His Glu Asn Glu Met Thr Val Ile Gly
 145                 150                 155                 160
 Leu Phe Asn Ser Val Ile Gln Ile His Leu Leu Leu Ile Met Asn Lys
                 165                 170                 175    
 Ala Ser Pro Glu Tyr Glu Glu Asn Met His Arg Tyr Gln Lys Ala Ala
             180                 185                 190        
 Lys Leu Phe Gln Gly Lys Ile Leu Phe Ile Leu Val Asp Ser Gly Met
         195                 200                 205            
 Lys Glu Asn Gly Lys Val Ile Ser Phe Phe Lys Leu Lys Glu Ser Gln
     210                 215                 220                
 Leu Pro Ala Leu Ala Ile Tyr Gln Thr Leu Asp Asp Glu Trp Asp Thr
 225                 230                 235                 240
 Leu Pro Thr Ala Glu Val Ser Val Glu His Val Gln Asn Phe Cys Asp
                 245                 250                 255    
 Gly Phe Leu Ser Gly Lys Leu Leu Lys Pro Tyr Met Ala Arg Pro Arg
             260                 265                 270        
 Glu Leu Glu Lys Glu Lys Val Lys His Glu His Leu Leu Ser Val Glu
         275                 280                 285            
 Leu Leu Glu Lys Ser Pro Trp Asn Pro Gly Leu Gln His Ala Met Ile
     290                 295                 300                
 Ala Pro Asp Leu Cys Thr Thr Pro Asp His Phe Leu Lys Tyr Leu Lys
 305                 310                 315                 320
 Pro Arg Ile Gln Glu Val Leu Lys Ala Ser Leu Ala Leu Gly Met Ile
                 325                 330                 335    
 Ala Glu Thr Leu Arg Glu Leu Ser Glu Leu Val Thr Ser Thr Phe Leu
             340                 345                 350        
 Asp Ala Leu Glu Thr Glu Met Leu Leu Ser Ala His Lys Asn Gly Gln
         355                 360                 365            
 Pro Arg Ala Ser Leu Pro Thr Ala Ala Thr Gln Asp Pro Glu Thr Asp
     370                 375                 380                
 Leu Gln Asp Glu Thr Met Lys Ser Leu Ile Leu Leu Ala Ile Leu Ala
 385                 390                 395                 400
 Ala Leu Ala Val Val Thr Leu Cys Tyr Gly Glu Trp Gln Lys Glu Glu
                 405                 410                 415    
 Asn Phe Gly Phe Asp Ile Val Ser Val Leu Ser Leu Asn Trp His Arg
             420                 425                 430        
 Ala Gln Glu Ser His Glu Ser Met Glu Ser Tyr Glu Leu Asn Pro Phe
         435                 440                 445            
 Ile Asn Arg Arg Asn Ala Asn Thr Phe Ile Ser Pro Gln Gln Arg Trp
     450                 455                 460                
 Arg Ala Lys Val Gln Glu Arg Ile Arg Glu Arg Ser Lys Pro Val His
 465                 470                 475                 480
 Glu Leu Asn Arg Glu Ala Cys Asp Asp Tyr Arg Leu Cys Glu Arg Tyr
                 485                 490                 495    
 Ala Met Val Tyr Gly Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe Arg Lys
             500                 505                 510        
 Arg Arg Gly Thr Lys
         515        



      <210> 279
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 279
 Met Cys Gly Phe Phe Phe Val Phe Phe Phe Trp Arg Arg Ser Leu Ala
   1               5                  10                  15    
 Leu Ser Pro Arg Leu Glu Cys Ser Gly Ala Ile Ser Ala His Cys Asn
              20                  25                  30        
 Leu Cys Leu Leu Gly Ser Asn Asp Ser Pro Ala Ser Ala Ser Gln Val
          35                  40                  45            
 Ala Gly Ile Ile Gly Ala His His His Ala Trp Leu Ile Phe Tyr Phe
      50                  55                  60                





      <210> 280
      <211> 600
      <212> PRT
      <213> Homo sapiens


      <400> 280
 Met Ala Pro Pro Gly Ser Ser Thr Val Phe Leu Leu Ala Leu Thr Ile
   1               5                  10                  15    
 Ile Ala Ser Thr Trp Ala Leu Thr Pro Thr His Tyr Leu Thr Lys His
              20                  25                  30        
 Asp Val Glu Arg Leu Lys Ala Ser Leu Asp Arg Pro Phe Thr Asn Leu
          35                  40                  45            
 Glu Ser Ala Phe Tyr Ser Ile Val Gly Leu Ser Ser Leu Gly Ala Gln
      50                  55                  60                
 Val Pro Asp Ala Lys Lys Ala Cys Thr Tyr Ile Arg Ser Asn Leu Asp
  65                  70                  75                  80
 Pro Ser Asn Val Asp Ser Leu Phe Tyr Ala Ala Gln Ala Ser Gln Ala
                  85                  90                  95    
 Leu Ser Gly Cys Glu Ile Ser Ile Ser Asn Glu Thr Lys Asp Leu Leu
             100                 105                 110        
 Leu Ala Ala Val Ser Glu Asp Ser Ser Val Thr Gln Ile Tyr His Ala
         115                 120                 125            
 Val Ala Ala Leu Ser Gly Phe Gly Leu Pro Leu Ala Ser Gln Glu Ala
     130                 135                 140                
 Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu Thr Val Leu Ala
 145                 150                 155                 160
 Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser Gln Gln Ala Asp
                 165                 170                 175    
 Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val Ala Arg Leu Asp
             180                 185                 190        
 Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly Leu Glu Thr Thr
         195                 200                 205            
 Ala Leu Phe Val Ala Ala Thr Tyr Lys Leu Met Asp His Val Gly Thr
     210                 215                 220                
 Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu Met Asn Ala Ile
 225                 230                 235                 240
 Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala Phe Ser Val Ala
                 245                 250                 255    
 Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His Val Pro Val Val
             260                 265                 270        
 Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu Gln Ala Ile Leu
         275                 280                 285            
 Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu Thr Gln Ala Thr
     290                 295                 300                
 Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg Ala Thr Val Leu
 305                 310                 315                 320
 Gln Lys Thr Ser Phe Thr Pro Val Gly Asp Val Phe Glu Leu Asn Phe
                 325                 330                 335    
 Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe Leu Val Glu Val
             340                 345                 350        
 Glu Gly Asp Asn Arg Tyr Ile Ala Asn Thr Val Glu Leu Arg Val Lys
         355                 360                 365            
 Ile Ser Thr Glu Val Gly Ile Thr Asn Val Asp Leu Ser Thr Val Asp
     370                 375                 380                
 Lys Asp Gln Ser Ile Ala Pro Lys Thr Thr Arg Val Thr Tyr Pro Ala
 385                 390                 395                 400
 Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His Gln Asn Phe Ala Leu
                 405                 410                 415    
 Phe Phe Gln Leu Val Asp Val Asn Thr Gly Ala Glu Leu Thr Pro His
             420                 425                 430        
 Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr Gly Gln Glu Val Val
         435                 440                 445            
 Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr Lys Phe Glu Leu Asp
     450                 455                 460                
 Thr Ser Glu Arg Lys Ile Glu Phe Asp Ser Ala Ser Gly Thr Tyr Thr
 465                 470                 475                 480
 Leu Tyr Leu Ile Ile Gly Asp Ala Thr Leu Lys Asn Pro Ile Leu Trp
                 485                 490                 495    
 Asn Val Ala Asp Val Val Ile Lys Phe Pro Glu Glu Glu Ala Pro Ser
             500                 505                 510        
 Thr Val Leu Ser Gln Asn Leu Phe Thr Pro Lys Gln Glu Ile Gln Trp
         515                 520                 525            
 Ile Arg Ile Gly Ala Asn Val Ser Asn Phe Thr Phe Ala Pro Ser Thr
     530                 535                 540                
 Ile Ile Phe His Leu Gly His Ala Ala Met Leu Gly Leu Met Tyr Val
 545                 550                 555                 560
 Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr Leu Lys Tyr Leu Ala Ile
                 565                 570                 575    
 Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met Leu Ala Gln Gln
             580                 585                 590        
 Ala Val Lys Arg Thr Ala His
         595                



      <210> 281
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 281
 Met Gln Gly Ser Lys Val Phe Ile Lys Lys Cys Ser Thr Phe His Leu
   1               5                  10                  15    
 Pro Glu Lys Cys Lys Ser Ala Pro Lys Gly Val Thr Ala Ala Pro Ser
              20                  25                  30        
 Ser Glu Pro Gln Lys Leu Glu Arg Trp Ile Ala Pro Val Ser Lys Val
          35                  40                  45            
 Thr Val Gly Gly Arg Phe Ala Tyr Thr Ala Ser Asn Asn Ala Lys Leu
      50                  55                  60                
 Met Glu Pro Thr Trp Lys Met Ala Trp His Gln Leu Leu Glu Lys Lys
  65                  70                  75                  80
 Thr His Ser Pro Leu Thr Cys Gln Ser His Ile Arg Ala Trp Ile Trp
                  85                  90                  95    
 Pro Ser Cys Val Pro Gly Ser Met Ala Arg Asn Leu Tyr Ser Gln Ile
             100                 105                 110        
 Leu Thr Ile Ala Pro Asn Trp Asn Gln Pro Thr Tyr Pro Ser Gly Arg
         115                 120                 125            
 Glu Trp Met Leu Lys Asn Ala Arg Ile Ala Ile Gly
     130                 135                 140



      <210> 282
      <211> 323
      <212> PRT
      <213> Homo sapiens


      <400> 282
 Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser
   1               5                  10                  15    
 Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg Ala Leu
              20                  25                  30        
 Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser Thr Cys
          35                  40                  45            
 Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met
      50                  55                  60                
 Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu
  65                  70                  75                  80
 Ile Ile Leu Ile Val Glu Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu
                  85                  90                  95    
 Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe
             100                 105                 110        
 Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu
         115                 120                 125            
 Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe Phe Ser
     130                 135                 140                
 Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala
 145                 150                 155                 160
 Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu
                 165                 170                 175    
 Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe Ile Ser
             180                 185                 190        
 Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys Val Ala
         195                 200                 205            
 Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn
     210                 215                 220                
 Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser Phe Leu
 225                 230                 235                 240
 Ser Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr Ala Leu Val
                 245                 250                 255    
 Leu Trp Pro Leu Tyr Gln Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg
             260                 265                 270        
 Arg Ser Arg Asp Val Ser Cys Ser Arg Ser His Ala Tyr Tyr Val Cys
         275                 280                 285            
 Ala Trp Asp Arg Arg Leu Ala Val Ala Ile Leu Thr Ala Ile Asn Leu
     290                 295                 300                
 Leu Ala Tyr Val Ala Asp Leu Val His Ser Ala His Leu Val Phe Val
 305                 310                 315                 320
 Lys Val
        



      <210> 283
      <211> 680
      <212> PRT
      <213> Homo sapiens


      <400> 283
 Met Ile Asn Met Gly Asp Ser His Val Asp Thr Ser Ser Thr Val Ser
   1               5                  10                  15    
 Glu Ala Val Ala Glu Glu Val Ser Leu Phe Ser Met Thr Asp Met Ile
              20                  25                  30        
 Leu Phe Ser Leu Ile Val Gly Leu Leu Thr Tyr Trp Phe Leu Phe Arg
          35                  40                  45            
 Lys Lys Lys Glu Glu Val Pro Glu Phe Thr Lys Ile Gln Thr Leu Thr
      50                  55                  60                
 Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys Met Lys Lys Thr Gly
  65                  70                  75                  80
 Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Glu
                  85                  90                  95    
 Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg Tyr Gly Met Arg Gly
             100                 105                 110        
 Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala Asp Leu Ser Ser Leu
         115                 120                 125            
 Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys Met Ala Thr Tyr Gly
     130                 135                 140                
 Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe Tyr Asp Trp Leu Gln
 145                 150                 155                 160
 Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe Ala Val Phe Gly Leu
                 165                 170                 175    
 Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met Gly Lys Tyr Val Asp
             180                 185                 190        
 Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile Phe Glu Leu Gly Leu
         195                 200                 205            
 Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe Ile Thr Trp Arg Glu
     210                 215                 220                
 Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly Val Glu Ala Thr Gly
 225                 230                 235                 240
 Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val Val His Thr Asp Ile
                 245                 250                 255    
 Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly Arg Leu Lys Ser Tyr
             260                 265                 270        
 Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn Pro Phe Leu Ala Ala
         275                 280                 285            
 Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr Glu Arg His Leu Met
     290                 295                 300                
 His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile Arg Tyr Glu Ser Gly
 305                 310                 315                 320
 Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser Ala Leu Val Asn Gln
                 325                 330                 335    
 Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val Val Met Ser Leu Asn
             340                 345                 350        
 Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro Phe Pro Cys Pro Thr
         355                 360                 365            
 Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp Ile Thr Asn Pro Pro
     370                 375                 380                
 Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr Ala Ser Glu Pro Ser
 385                 390                 395                 400
 Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser Ser Gly Glu Gly Lys
                 405                 410                 415    
 Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg Arg His Ile Leu Ala
             420                 425                 430        
 Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro Ile Asp His Leu Cys
         435                 440                 445            
 Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr Ser Ile Ala Ser Ser
     450                 455                 460                
 Ser Lys Val His Pro Asn Ser Val His Ile Cys Ala Val Val Val Glu
 465                 470                 475                 480
 Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly Val Ala Thr Asn Trp
                 485                 490                 495    
 Leu Arg Ala Lys Glu Pro Val Gly Glu Asn Gly Gly Arg Ala Leu Val
             500                 505                 510        
 Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu Pro Phe Lys Ala Thr
         515                 520                 525            
 Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Ile
     530                 535                 540                
 Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln Gln Gly Lys Glu Val
 545                 550                 555                 560
 Gly Glu Thr Leu Leu Tyr Tyr Gly Cys Arg Arg Ser Asp Glu Asp Tyr
                 565                 570                 575    
 Leu Tyr Arg Glu Glu Leu Ala Gln Phe His Arg Asp Gly Ala Leu Thr
             580                 585                 590        
 Gln Leu Asn Val Ala Phe Ser Arg Glu Gln Ser His Lys Val Tyr Val
         595                 600                 605            
 Gln His Leu Leu Lys Gln Asp Arg Glu His Leu Trp Lys Leu Ile Glu
     610                 615                 620                
 Gly Gly Ala His Ile Tyr Val Cys Gly Asp Ala Arg Asn Met Ala Arg
 625                 630                 635                 640
 Asp Val Gln Asn Thr Phe Tyr Asp Ile Val Ala Glu Leu Gly Ala Met
                 645                 650                 655    
 Glu His Ala Gln Ala Val Asp Tyr Ile Lys Lys Leu Met Thr Lys Gly
             660                 665                 670        
 Arg Tyr Ser Leu Asp Val Trp Ser
         675                 680



      <210> 284
      <211> 590
      <212> PRT
      <213> Homo sapiens


      <400> 284
 Met Ser Arg Arg Leu Leu Pro Arg Ala Glu Lys Arg Arg Arg Arg Leu
   1               5                  10                  15    
 Glu Gln Arg Gln Gln Pro Asp Glu Gln Arg Arg Arg Ser Gly Ala Met
              20                  25                  30        
 Val Lys Met Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Arg Tyr Tyr
          35                  40                  45            
 Gly Gly Gly Ser Glu Gly Gly Arg Ala Pro Lys Arg Leu Lys Thr Asp
      50                  55                  60                
 Asn Ala Gly Asp Gln His Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala
  65                  70                  75                  80
 Gly Ala Ala Gly Gly Gly Gly Gly Gly Glu Asn Tyr Asp Asp Pro His
                  85                  90                  95    
 Lys Thr Pro Ala Ser Pro Val Val His Ile Arg Gly Leu Ile Asp Gly
             100                 105                 110        
 Val Val Glu Ala Asp Leu Val Glu Ala Leu Gln Glu Phe Gly Pro Ile
         115                 120                 125            
 Ser Tyr Val Val Val Met Pro Lys Lys Arg Gln Ala Leu Val Glu Phe
     130                 135                 140                
 Glu Asp Val Leu Gly Ala Cys Asn Ala Val Asn Tyr Ala Ala Asp Asn
 145                 150                 155                 160
 Gln Ile Tyr Ile Ala Gly His Pro Ala Phe Val Asn Tyr Ser Thr Ser
                 165                 170                 175    
 Gln Lys Ile Ser Arg Pro Gly Asp Ser Asp Asp Ser Arg Ser Val Asn
             180                 185                 190        
 Ser Val Leu Leu Phe Thr Ile Leu Asn Pro Ile Tyr Ser Ile Thr Thr
         195                 200                 205            
 Asp Val Leu Tyr Thr Ile Cys Asn Pro Cys Gly Pro Val Gln Arg Ile
     210                 215                 220                
 Val Ile Phe Arg Lys Asn Gly Val Gln Ala Met Val Glu Phe Asp Ser
 225                 230                 235                 240
 Val Gln Ser Ala Gln Arg Ala Lys Ala Ser Leu Asn Gly Ala Asp Ile
                 245                 250                 255    
 Tyr Ser Gly Cys Cys Thr Leu Lys Ile Glu Tyr Ala Lys Pro Thr Arg
             260                 265                 270        
 Leu Asn Val Phe Lys Asn Asp Gln Asp Thr Trp Asp Tyr Thr Asn Pro
         275                 280                 285            
 Asn Leu Ser Gly Gln Gly Asp Pro Gly Ser Asn Pro Asn Lys Arg Gln
     290                 295                 300                
 Arg Gln Pro Pro Leu Leu Gly Asp His Pro Ala Glu Tyr Gly Gly Pro
 305                 310                 315                 320
 His Gly Gly Tyr His Ser His Tyr His Asp Glu Gly Tyr Gly Pro Pro
                 325                 330                 335    
 Pro Pro His Tyr Glu Gly Arg Arg Met Gly Pro Pro Val Gly Gly His
             340                 345                 350        
 Arg Arg Gly Pro Ser Arg Tyr Gly Pro Gln Tyr Gly His Pro Pro Pro
         355                 360                 365            
 Pro Pro Pro Pro Pro Glu Tyr Gly Pro His Ala Asp Ser Pro Val Leu
     370                 375                 380                
 Met Val Tyr Gly Leu Asp Gln Ser Lys Met Asn Cys Asp Arg Val Phe
 385                 390                 395                 400
 Asn Val Phe Cys Leu Tyr Gly Asn Val Glu Lys Val Lys Phe Met Lys
                 405                 410                 415    
 Ser Lys Pro Gly Ala Ala Met Val Glu Met Ala Asp Gly Tyr Ala Val
             420                 425                 430        
 Asp Arg Ala Ile Thr His Leu Asn Asn Asn Phe Met Phe Gly Gln Lys
         435                 440                 445            
 Leu Asn Val Cys Val Ser Lys Gln Pro Ala Ile Met Pro Gly Gln Ser
     450                 455                 460                
 Tyr Gly Leu Glu Asp Gly Ser Cys Ser Tyr Lys Asp Phe Ser Glu Ser
 465                 470                 475                 480
 Arg Asn Asn Arg Phe Ser Thr Pro Glu Gln Ala Ala Lys Asn Arg Ile
                 485                 490                 495    
 Gln His Pro Ser Asn Val Leu His Phe Phe Asn Ala Pro Leu Glu Val
             500                 505                 510        
 Thr Glu Glu Asn Phe Phe Glu Ile Cys Asp Glu Leu Gly Val Lys Arg
         515                 520                 525            
 Pro Ser Ser Val Lys Val Phe Ser Gly Lys Ser Glu Arg Ser Ser Ser
     530                 535                 540                
 Gly Leu Leu Glu Trp Glu Ser Lys Ser Asp Ala Leu Glu Thr Leu Gly
 545                 550                 555                 560
 Phe Leu Asn His Tyr Gln Met Lys Asn Pro Asn Gly Pro Tyr Pro Tyr
                 565                 570                 575    
 Thr Leu Lys Leu Cys Phe Ser Thr Ala Gln His Ala Ser
             580                 585                



      <210> 285
      <211> 593
      <212> PRT
      <213> Homo sapiens


      <400> 285
 Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr
   1               5                  10                  15    
 Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro
              20                  25                  30        
 Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser
          35                  40                  45            
 Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His
      50                  55                  60                
 Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro
  65                  70                  75                  80
 Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn
                  85                  90                  95    
 Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly
             100                 105                 110        
 Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp
         115                 120                 125            
 Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile
     130                 135                 140                
 Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys
 145                 150                 155                 160
 Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu
                 165                 170                 175    
 Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr
             180                 185                 190        
 Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His
         195                 200                 205            
 Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn
     210                 215                 220                
 Asp Lys Lys Lys Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys
 225                 230                 235                 240
 Cys Lys Lys Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser
                 245                 250                 255    
 Asn Phe Gly Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu
             260                 265                 270        
 Glu Ala Asn Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln
         275                 280                 285            
 Arg Ile Ala Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn
     290                 295                 300                
 Lys Ser Asp Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu
 305                 310                 315                 320
 Ser His Ile Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu
                 325                 330                 335    
 Pro Pro Asp Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg
             340                 345                 350        
 Glu Gln Phe Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe
         355                 360                 365            
 Val Leu Phe Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala
     370                 375                 380                
 Arg Thr Phe Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro
 385                 390                 395                 400
 Asn Ala Glu Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr
                 405                 410                 415    
 Ile Tyr Ser Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala
             420                 425                 430        
 Phe Asp Phe Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys
         435                 440                 445            
 Leu Lys Glu Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser
     450                 455                 460                
 Met Glu Asn Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys
 465                 470                 475                 480
 Lys Asp Lys Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile
                 485                 490                 495    
 Thr Leu Asp Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr
             500                 505                 510        
 Lys Gln Arg Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln
         515                 520                 525            
 Glu Pro Asp Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn
     530                 535                 540                
 Glu Val Glu Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys
 545                 550                 555                 560
 Met Asn Trp Thr Val Asp Gly Cys Gly Ser Trp Phe Trp Phe Arg Ala
                 565                 570                 575    
 Glu Ala Ser Val Lys Ala Leu Gly Leu Thr Leu Asn Val Leu Phe Gly
             580                 585                 590        





      <210> 286
      <211> 606
      <212> PRT
      <213> Homo sapiens


      <400> 286
 Met Ser Ile Val Ile Pro Leu Gly Val Asp Thr Ala Glu Thr Ser Tyr
   1               5                  10                  15    
 Leu Glu Met Ala Ala Gly Ser Glu Pro Glu Ser Val Glu Ala Ser Pro
              20                  25                  30        
 Val Val Val Glu Lys Ser Asn Ser Tyr Pro His Gln Leu Tyr Thr Ser
          35                  40                  45            
 Ser Ser His His Ser His Ser Tyr Ile Gly Leu Pro Tyr Ala Asp His
      50                  55                  60                
 Asn Tyr Gly Ala Arg Pro Pro Pro Thr Pro Pro Ala Ser Pro Pro Pro
  65                  70                  75                  80
 Ser Val Leu Ile Ser Lys Asn Glu Val Gly Ile Phe Thr Thr Pro Asn
                  85                  90                  95    
 Phe Asp Glu Thr Ser Ser Ala Thr Thr Ile Ser Thr Ser Glu Asp Gly
             100                 105                 110        
 Ser Tyr Gly Thr Asp Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp
         115                 120                 125            
 Asp Gly Tyr Met Ile Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile
     130                 135                 140                
 Asp Cys Met Gly Ile Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys
 145                 150                 155                 160
 Glu Arg Cys Gln Pro Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu
                 165                 170                 175    
 Gln Arg Arg Lys Arg Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr
             180                 185                 190        
 Glu Ser Gly Asp Glu Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His
         195                 200                 205            
 Thr Pro Thr Ser Ile Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn
     210                 215                 220                
 Asp Lys Lys Lys Lys Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys
 225                 230                 235                 240
 Cys Lys Lys Ala Phe Arg Glu Gly Ser Arg Lys Ser Ser Arg Val Lys
                 245                 250                 255    
 Gly Ser Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly
             260                 265                 270        
 Trp Glu Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn
         275                 280                 285            
 Asn Asn Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala
     290                 295                 300                
 Leu Arg Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp
 305                 310                 315                 320
 Leu Asn Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile
                 325                 330                 335    
 Gln Lys Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Leu Pro Pro Asp
             340                 345                 350        
 Ala Leu Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe
         355                 360                 365            
 Glu Ala Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe
     370                 375                 380                
 Tyr Ser Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe
 385                 390                 395                 400
 Gly Asn Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu
                 405                 410                 415    
 Val Arg His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser
             420                 425                 430        
 Ile His Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe
         435                 440                 445            
 Asp Tyr Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu
     450                 455                 460                
 Asn Pro Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn
 465                 470                 475                 480
 Ile Asn Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys
                 485                 490                 495    
 Asp Ile Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp
             500                 505                 510        
 Cys Glu Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg
         515                 520                 525            
 Lys Leu Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp
     530                 535                 540                
 Phe Ile Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu
 545                 550                 555                 560
 Met Glu Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Asn Trp
                 565                 570                 575    
 Thr Val Asp Gly Cys Gly Ser Trp Phe Trp Phe Arg Ala Glu Ala Ser
             580                 585                 590        
 Val Lys Ala Leu Gly Leu Thr Leu Asn Val Leu Phe Gly
         595                 600                 605



      <210> 287
      <211> 3119
      <212> PRT
      <213> Homo sapiens


      <400> 287
 Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu
   1               5                  10                  15    
 Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn
              20                  25                  30        
 Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Glu Pro
          35                  40                  45            
 Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp
      50                  55                  60                
 Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu
  65                  70                  75                  80
 Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser
                  85                  90                  95    
 Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile
             100                 105                 110        
 Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr
         115                 120                 125            
 Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu
     130                 135                 140                
 Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu
 145                 150                 155                 160
 Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys
                 165                 170                 175    
 Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe
             180                 185                 190        
 Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys
         195                 200                 205            
 Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp
     210                 215                 220                
 Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly
 225                 230                 235                 240
 Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu
                 245                 250                 255    
 Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe
             260                 265                 270        
 Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala
         275                 280                 285            
 Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala
     290                 295                 300                
 Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val
 305                 310                 315                 320
 Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro
                 325                 330                 335    
 Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu
             340                 345                 350        
 Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu
         355                 360                 365            
 Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro
     370                 375                 380                
 Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr
 385                 390                 395                 400
 Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile
                 405                 410                 415    
 Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser
             420                 425                 430        
 Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser
         435                 440                 445            
 Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu
     450                 455                 460                
 Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser
 465                 470                 475                 480
 Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys
                 485                 490                 495    
 Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr
             500                 505                 510        
 Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu
         515                 520                 525            
 Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val
     530                 535                 540                
 Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro
 545                 550                 555                 560
 Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val
                 565                 570                 575    
 Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala
             580                 585                 590        
 Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile
         595                 600                 605            
 Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu
     610                 615                 620                
 Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe
 625                 630                 635                 640
 Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly
                 645                 650                 655    
 Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp
             660                 665                 670        
 Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu
         675                 680                 685            
 Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu
     690                 695                 700                
 Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu
 705                 710                 715                 720
 Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr
                 725                 730                 735    
 Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg
             740                 745                 750        
 Cys Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val
         755                 760                 765            
 Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro
     770                 775                 780                
 Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro
 785                 790                 795                 800
 Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn
                 805                 810                 815    
 Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu
             820                 825                 830        
 Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr
         835                 840                 845            
 Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp
     850                 855                 860                
 Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala
 865                 870                 875                 880
 Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe
                 885                 890                 895    
 Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val
             900                 905                 910        
 Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala
         915                 920                 925            
 Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp
     930                 935                 940                
 Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr
 945                 950                 955                 960
 Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe
                 965                 970                 975    
 Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr
             980                 985                 990        
 Thr Glu Leu Ser Gln Asp Ser Lys Thr Leu Lys Val Asp Glu Glu Thr
         995                1000                1005            
 Glu Asn Thr Met Arg Val Thr Trp Lys Pro Ala Pro Gly Lys Val Val
    1010                1015                1020                
 Asn Tyr Arg Val Val Tyr Arg Pro His Gly Arg Gly Lys Gln Met Val
1025                1030                1035                1040
 Ala Lys Val Pro Pro Thr Val Thr Ser Thr Val Leu Lys Arg Leu Gln
                1045                1050                1055    
 Pro Gln Thr Thr Tyr Asp Ile Thr Val Leu Pro Ile Tyr Lys Met Gly
            1060                1065                1070        
 Glu Gly Lys Leu Arg Gln Gly Ser Gly Thr Thr Ala Ser Arg Phe Lys
        1075                1080                1085            
 Ser Pro Arg Asn Leu Lys Thr Ser Asp Pro Thr Met Ser Ser Phe Arg
    1090                1095                1100                
 Val Thr Trp Glu Pro Ala Pro Gly Glu Val Lys Gly Tyr Lys Val Thr
1105                1110                1115                1120
 Phe His Pro Thr Gly Asp Asp Arg Arg Leu Gly Glu Leu Val Val Gly
                1125                1130                1135    
 Pro Tyr Asp Asn Thr Val Val Leu Glu Glu Leu Arg Ala Gly Thr Thr
            1140                1145                1150        
 Tyr Lys Val Asn Val Phe Gly Met Phe Asp Gly Gly Glu Ser Ser Pro
        1155                1160                1165            
 Leu Val Gly Gln Glu Met Thr Thr Leu Ser Asp Thr Thr Val Met Pro
    1170                1175                1180                
 Ile Leu Ser Ser Gly Met Glu Cys Leu Thr Arg Ala Glu Ala Asp Ile
1185                1190                1195                1200
 Val Leu Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Ala Asn Phe Arg
                1205                1210                1215    
 Thr Val Arg Ser Phe Ile Ser Arg Ile Val Glu Val Phe Asp Ile Gly
            1220                1225                1230        
 Pro Lys Arg Val Gln Ile Ala Leu Ala Gln Tyr Ser Gly Asp Pro Arg
        1235                1240                1245            
 Thr Glu Trp Gln Leu Asn Ala His Arg Asp Lys Lys Ser Leu Leu Gln
    1250                1255                1260                
 Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Met
1265                1270                1275                1280
 Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe Arg Thr Gln Ala Gly Met
                1285                1290                1295    
 Arg Pro Arg Ala Arg Lys Ile Gly Val Leu Ile Thr Asp Gly Lys Ser
            1300                1305                1310        
 Gln Asp Asp Val Glu Ala Pro Ser Lys Lys Leu Lys Asp Glu Gly Val
        1315                1320                1325            
 Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala Asp Glu Val Glu Leu Lys
    1330                1335                1340                
 Met Ile Ala Thr Asp Pro Asp Asp Thr His Asp Tyr Asn Val Ala Asp
1345                1350                1355                1360
 Phe Glu Ser Leu Ser Arg Ile Val Asp Asp Leu Thr Ile Asn Leu Cys
                1365                1370                1375    
 Asn Ser Val Lys Gly Pro Gly Asp Leu Glu Ala Pro Ser Asn Leu Val
            1380                1385                1390        
 Ile Ser Glu Arg Thr His Arg Ser Phe Arg Val Ser Trp Thr Pro Pro
        1395                1400                1405            
 Ser Asp Ser Val Asp Arg Tyr Lys Val Glu Tyr Tyr Pro Val Ser Gly
    1410                1415                1420                
 Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg Met Glu Thr Ser Thr Val
1425                1430                1435                1440
 Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr Val Val Asn Val Tyr Ser
                1445                1450                1455    
 Val Val Glu Asp Glu Tyr Ser Glu Pro Leu Lys Gly Thr Glu Lys Thr
            1460                1465                1470        
 Leu Pro Val Pro Val Val Ser Leu Asn Ile Tyr Asp Val Gly Pro Thr
        1475                1480                1485            
 Thr Met His Val Gln Trp Gln Pro Val Gly Gly Ala Thr Gly Tyr Ile
    1490                1495                1500                
 Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu Pro Thr Arg Pro Lys Glu
1505                1510                1515                1520
 Val Arg Leu Gly Pro Thr Val Asn Asp Met Gln Leu Thr Asp Leu Val
                1525                1530                1535    
 Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val Leu His Asp Leu
            1540                1545                1550        
 Thr Ser Glu Pro Val Thr Val Arg Glu Val Thr Leu Pro Leu Pro Arg
        1555                1560                1565            
 Pro Gln Asp Leu Lys Leu Arg Asp Val Thr His Ser Thr Met Asn Val
    1570                1575                1580                
 Phe Trp Glu Pro Val Pro Gly Lys Val Arg Lys Tyr Ile Val Arg Tyr
1585                1590                1595                1600
 Lys Thr Pro Glu Glu Asp Val Lys Glu Val Glu Val Asp Arg Ser Glu
                1605                1610                1615    
 Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser Gln Thr Leu Tyr Thr Val
            1620                1625                1630        
 Ser Val Ser Ala Val His Asp Glu Gly Glu Ser Pro Pro Val Thr Ala
        1635                1640                1645            
 Gln Glu Thr Thr Arg Pro Val Pro Ala Pro Thr Asn Leu Lys Ile Thr
    1650                1655                1660                
 Glu Val Thr Ser Glu Gly Phe Arg Gly Thr Trp Asp His Gly Ala Ser
1665                1670                1675                1680
 Asp Val Ser Leu Tyr Arg Ile Thr Trp Gly Pro Phe Gly Ser Ser Asp
                1685                1690                1695    
 Lys Met Glu Thr Ile Leu Asn Gly Asp Glu Asn Thr Leu Val Phe Glu
            1700                1705                1710        
 Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val Ser Ile Thr Ala Ile Tyr
        1715                1720                1725            
 Ala Asp Glu Ser Glu Ser Asp Asp Leu Ile Gly Ser Glu Arg Thr Leu
    1730                1735                1740                
 Pro Ile Leu Thr Thr Gln Ala Pro Lys Ser Gly Pro Arg Asn Leu Gln
1745                1750                1755                1760
 Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys Trp Asp Pro Ala
                1765                1770                1775    
 Ser Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln Pro Ser Thr Gly
            1780                1785                1790        
 Glu Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg Gln Asn Ser Val
        1795                1800                1805            
 Val Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr Ile Thr Val Ser
    1810                1815                1820                
 Ser Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr Gly Arg Gly Lys
1825                1830                1835                1840
 Thr Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val Tyr Asp Pro Ser
                1845                1850                1855    
 Thr Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu Gly Asn Pro Arg
            1860                1865                1870        
 Gln Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly Pro Glu Glu Leu
        1875                1880                1885            
 Val Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu Arg Asn Leu Gln
    1890                1895                1900                
 Pro Asp Thr Ser Tyr Thr Val Thr Val Val Pro Val Tyr Thr Glu Gly
1905                1910                1915                1920
 Asp Gly Gly Arg Thr Ser Asp Thr Gly Arg Thr Leu Met Arg Gly Leu
                1925                1930                1935    
 Ala Arg Asn Val Gln Val Tyr Asn Pro Thr Pro Asn Arg Leu Gly Val
            1940                1945                1950        
 Arg Trp Asp Pro Ala Pro Gly Pro Val Leu Gln Tyr Arg Val Val Tyr
        1955                1960                1965            
 Ser Pro Val Asp Gly Thr Arg Pro Ser Glu Ser Ile Val Val Pro Gly
    1970                1975                1980                
 Asn Thr Arg Met Val His Leu Glu Arg Leu Ile Pro Asp Thr Leu Tyr
1985                1990                1995                2000
 Ser Val Asn Leu Val Ala Leu Tyr Ser Asp Gly Glu Gly Asn Pro Ser
                2005                2010                2015    
 Pro Ala Gln Gly Arg Thr Leu Pro Arg Ser Gly Pro Arg Asn Leu Arg
            2020                2025                2030        
 Val Phe Gly Glu Thr Thr Asn Ser Leu Ser Val Ala Trp Asp His Ala
        2035                2040                2045            
 Asp Gly Pro Val Gln Gln Tyr Arg Ile Ile Tyr Ser Pro Thr Val Gly
    2050                2055                2060                
 Asp Pro Ile Asp Glu Tyr Thr Thr Val Pro Gly Arg Arg Asn Asn Val
2065                2070                2075                2080
 Ile Leu Gln Pro Leu Gln Pro Asp Thr Pro Tyr Lys Ile Thr Val Ile
                2085                2090                2095    
 Ala Val Tyr Glu Asp Gly Asp Gly Gly His Leu Thr Gly Asn Gly Arg
            2100                2105                2110        
 Thr Val Gly Leu Leu Pro Pro Gln Asn Ile His Ile Ser Asp Glu Trp
        2115                2120                2125            
 Tyr Thr Arg Phe Arg Val Ser Trp Asp Pro Ser Pro Ser Pro Val Leu
    2130                2135                2140                
 Gly Tyr Lys Ile Val Tyr Lys Pro Val Gly Ser Asn Glu Pro Met Glu
2145                2150                2155                2160
 Ala Phe Val Gly Glu Met Thr Ser Tyr Thr Leu His Asn Leu Asn Pro
                2165                2170                2175    
 Ser Thr Thr Tyr Asp Val Asn Val Tyr Ala Gln Tyr Asp Ser Gly Leu
            2180                2185                2190        
 Ser Val Pro Leu Thr Asp Gln Gly Thr Thr Leu Tyr Leu Asn Val Thr
        2195                2200                2205            
 Asp Leu Lys Thr Tyr Gln Ile Gly Trp Asp Thr Phe Cys Val Lys Trp
    2210                2215                2220                
 Ser Pro His Arg Ala Ala Thr Ser Tyr Arg Leu Lys Leu Ser Pro Ala
2225                2230                2235                2240
 Asp Gly Thr Arg Gly Gln Glu Ile Thr Val Arg Gly Ser Glu Thr Ser
                2245                2250                2255    
 His Cys Phe Thr Gly Leu Ser Pro Asp Thr Asp Tyr Gly Val Thr Val
            2260                2265                2270        
 Phe Val Gln Thr Pro Asn Leu Glu Gly Pro Gly Val Ser Val Lys Glu
        2275                2280                2285            
 His Thr Thr Val Lys Pro Thr Glu Ala Pro Thr Glu Pro Pro Thr Pro
    2290                2295                2300                
 Pro Pro Pro Pro Thr Ile Pro Pro Ala Arg Asp Val Cys Lys Gly Ala
2305                2310                2315                2320
 Lys Ala Asp Ile Val Phe Leu Thr Asp Ala Ser Trp Ser Ile Gly Asp
                2325                2330                2335    
 Asp Asn Phe Asn Lys Val Val Lys Phe Ile Phe Asn Thr Val Gly Gly
            2340                2345                2350        
 Phe Asp Glu Ile Ser Pro Ala Gly Ile Gln Val Ser Phe Val Gln Tyr
        2355                2360                2365            
 Ser Asp Glu Val Lys Ser Glu Phe Lys Leu Asn Thr Tyr Asn Asp Lys
    2370                2375                2380                
 Ala Leu Ala Leu Gly Ala Leu Gln Asn Ile Arg Tyr Arg Gly Gly Asn
2385                2390                2395                2400
 Thr Arg Thr Gly Lys Ala Leu Thr Phe Ile Lys Glu Lys Val Leu Thr
                2405                2410                2415    
 Trp Glu Ser Gly Met Arg Lys Asn Val Pro Lys Val Leu Val Val Val
            2420                2425                2430        
 Thr Asp Gly Arg Ser Gln Asp Glu Val Lys Lys Ala Ala Leu Val Ile
        2435                2440                2445            
 Gln Gln Ser Gly Phe Ser Val Phe Val Val Gly Val Ala Asp Val Asp
    2450                2455                2460                
 Tyr Asn Glu Leu Ala Asn Ile Ala Ser Lys Pro Ser Glu Arg His Val
2465                2470                2475                2480
 Phe Ile Val Asp Asp Phe Glu Ser Phe Glu Lys Ile Glu Asp Asn Leu
                2485                2490                2495    
 Ile Thr Phe Val Cys Glu Thr Ala Thr Ser Ser Cys Pro Leu Ile Tyr
            2500                2505                2510        
 Leu Asp Gly Tyr Thr Ser Pro Gly Phe Lys Met Leu Glu Ala Tyr Asn
        2515                2520                2525            
 Leu Thr Glu Lys Asn Phe Ala Ser Val Gln Gly Val Ser Leu Glu Ser
    2530                2535                2540                
 Gly Ser Phe Pro Ser Tyr Ser Ala Tyr Arg Ile Gln Lys Asn Ala Phe
2545                2550                2555                2560
 Val Asn Gln Pro Thr Ala Asp Leu His Pro Asn Gly Leu Pro Pro Ser
                2565                2570                2575    
 Tyr Thr Ile Ile Leu Leu Phe Arg Leu Leu Pro Glu Thr Pro Ser Asp
            2580                2585                2590        
 Pro Phe Ala Ile Trp Gln Ile Thr Asp Arg Asp Tyr Lys Pro Gln Val
        2595                2600                2605            
 Gly Val Ile Ala Asp Pro Ser Ser Lys Thr Leu Ser Phe Phe Asn Lys
    2610                2615                2620                
 Asp Thr Arg Gly Glu Val Gln Thr Val Thr Phe Asp Thr Glu Glu Val
2625                2630                2635                2640
 Lys Thr Leu Phe Tyr Gly Ser Phe His Lys Val His Ile Val Val Thr
                2645                2650                2655    
 Ser Lys Ser Val Lys Ile Tyr Ile Asp Cys Tyr Glu Ile Ile Glu Lys
            2660                2665                2670        
 Asp Ile Lys Glu Ala Gly Asn Ile Thr Thr Asp Gly Tyr Glu Ile Leu
        2675                2680                2685            
 Gly Lys Leu Leu Lys Gly Glu Arg Lys Ser Ala Ala Phe Gln Ile Gln
    2690                2695                2700                
 Ser Phe Asp Ile Val Cys Ser Pro Val Trp Thr Ser Arg Asp Arg Cys
2705                2710                2715                2720
 Cys Asp Ile Pro Ser Arg Arg Asp Glu Gly Lys Cys Pro Ala Phe Pro
                2725                2730                2735    
 Asn Ser Cys Thr Cys Thr Gln Asp Ser Val Gly Pro Pro Gly Pro Pro
            2740                2745                2750        
 Gly Pro Ala Gly Gly Pro Gly Ala Lys Gly Pro Arg Gly Glu Arg Gly
        2755                2760                2765            
 Ile Ser Gly Ala Ile Gly Pro Pro Gly Pro Arg Gly Asp Ile Gly Pro
    2770                2775                2780                
 Pro Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly Pro Asn Gly Leu Ser
2785                2790                2795                2800
 Ile Pro Gly Glu Gln Gly Arg Gln Gly Met Lys Gly Asp Ala Gly Glu
                2805                2810                2815    
 Pro Gly Leu Pro Gly Arg Thr Gly Thr Pro Gly Leu Pro Gly Pro Pro
            2820                2825                2830        
 Gly Pro Met Gly Pro Pro Gly Asp Arg Gly Phe Thr Gly Lys Asp Ser
        2835                2840                2845            
 Ala Met Gly Pro Arg Gly Pro Pro Gly Arg Pro Gly Ser Pro Gly Ser
    2850                2855                2860                
 Pro Gly Val Thr Gly Pro Ser Gly Lys Pro Gly Lys Pro Gly Asp His
2865                2870                2875                2880
 Gly Arg Pro Gly Pro Ser Gly Leu Lys Gly Glu Lys Gly Asp Arg Gly
                2885                2890                2895    
 Asp Ile Ala Ser Gln Asn Met Met Arg Ala Val Ala Arg Gln Val Cys
            2900                2905                2910        
 Glu Gln Leu Ile Ser Gly Gln Met Asn Arg Phe Asn Gln Met Leu Asn
        2915                2920                2925            
 Gln Ile Pro Asn Asp Tyr Gln Ser Ser Arg Asn Gln Pro Gly Pro Pro
    2930                2935                2940                
 Gly Pro Pro Gly Pro Pro Gly Ser Ala Gly Ala Arg Gly Glu Pro Gly
2945                2950                2955                2960
 Pro Gly Gly Arg Pro Gly Phe Pro Gly Thr Pro Gly Met Gln Gly Pro
                2965                2970                2975    
 Pro Gly Glu Arg Gly Leu Pro Gly Glu Lys Gly Glu Arg Gly Thr Gly
            2980                2985                2990        
 Ser Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Gln Gly Glu
        2995                3000                3005            
 Ser Arg Thr Gly Pro Pro Gly Ser Thr Gly Ser Arg Gly Pro Pro Gly
    3010                3015                3020                
 Pro Pro Gly Arg Pro Gly Asn Ser Gly Ile Gln Gly Pro Pro Gly Pro
3025                3030                3035                3040
 Pro Gly Tyr Cys Asp Ser Ser Gln Cys Ala Ser Ile Pro Tyr Asn Gly
                3045                3050                3055    
 Gln Gly Tyr Pro Glu Pro Tyr Val Pro Glu Gly Gly Ala Tyr Leu Pro
            3060                3065                3070        
 Glu Arg Glu Pro Phe Ile Val Pro Val Glu Pro Glu Arg Thr Ala Glu
        3075                3080                3085            
 Tyr Glu Asp Tyr Gly Ala Asp Glu Pro Ala Glu Glu Pro Pro Glu Pro
    3090                3095                3100                
 His Arg Arg Trp Arg Arg Ala Leu Pro His Gly Pro Gly Gln
3105                3110                3115            



      <210> 288
      <211> 34
      <212> PRT
      <213> Homo sapiens


      <400> 288
 Met Arg Lys Lys Gln Arg Lys Lys Ala Glu Asn Ser Lys Asn Gln Asn
   1               5                  10                  15    
 Ala Ser Ser Pro Pro Lys Glu His Asn Ser Ser Pro Ala Lys Glu Gln
              20                  25                  30        
 Asn
    



      <210> 289
      <211> 31
      <212> PRT
      <213> Homo sapiens


      <400> 289
 Met Glu Ser Cys Ser Val Thr Gln Val Gly Val Gln Trp His Asn Gln
   1               5                  10                  15    
 Leu Thr Ala Thr Pro Pro Pro Arg Phe Lys Arg Leu Ser Ser
              20                  25                  30



      <210> 290
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 290
 Met Gln Ile Lys Thr Lys Met Arg Tyr His Phe Thr His Ser Arg Met
   1               5                  10                  15    
 Phe Ile Val Lys Lys Asp Ser Lys Cys Trp Gln Ile Cys Gly Glu Ile
              20                  25                  30        
 Glu Ile Leu Thr His Cys Cys Trp Lys Cys Thr Met Val Gln Ser Leu
          35                  40                  45            
 Trp Lys Ile Val
      50        



      <210> 291
      <211> 54
      <212> PRT
      <213> Homo sapiens


      <400> 291
 Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro Pro Thr His Gln Ala
   1               5                  10                  15    
 Ser Val Gly Leu Leu Asp Thr Pro Arg Ser Arg Glu Arg Ser Pro Ser
              20                  25                  30        
 Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu Pro Thr Arg Arg Thr
          35                  40                  45            
 Arg Thr Phe Ser Ala
      50            



      <210> 292
      <211> 468
      <212> PRT
      <213> Homo sapiens


      <400> 292
 Met Ala Thr Gly Ala Asp Val Arg Asp Ile Leu Glu Leu Gly Gly Pro
   1               5                  10                  15    
 Glu Gly Asp Ala Ala Ser Gly Thr Ile Ser Lys Lys Asp Ile Ile Asn
              20                  25                  30        
 Pro Asp Lys Lys Lys Ser Lys Lys Ser Ser Glu Thr Leu Thr Phe Lys
          35                  40                  45            
 Arg Pro Glu Gly Met His Arg Glu Val Tyr Ala Leu Leu Tyr Ser Asp
      50                  55                  60                
 Lys Lys Asp Ala Pro Pro Leu Leu Pro Ser Asp Thr Gly Gln Gly Tyr
  65                  70                  75                  80
 Arg Thr Val Lys Ala Lys Leu Gly Ser Lys Lys Val Arg Pro Trp Lys
                  85                  90                  95    
 Trp Met Pro Phe Thr Asn Pro Ala Arg Lys Asp Gly Ala Met Phe Phe
             100                 105                 110        
 His Trp Arg Arg Ala Ala Glu Glu Gly Lys Asp Tyr Pro Phe Ala Arg
         115                 120                 125            
 Phe Asn Lys Thr Val Gln Val Pro Val Tyr Ser Glu Gln Glu Tyr Gln
     130                 135                 140                
 Leu Tyr Leu His Asp Asp Ala Trp Thr Lys Ala Glu Thr Asp His Leu
 145                 150                 155                 160
 Phe Asp Leu Ser Arg Arg Phe Asp Leu Arg Phe Val Val Ile His Asp
                 165                 170                 175    
 Arg Tyr Asp His Gln Gln Phe Lys Lys Arg Ser Val Glu Asp Leu Lys
             180                 185                 190        
 Glu Arg Tyr Tyr His Ile Cys Ala Lys Leu Ala Asn Val Arg Ala Val
         195                 200                 205            
 Pro Gly Thr Asp Leu Lys Ile Pro Val Phe Asp Ala Gly His Glu Arg
     210                 215                 220                
 Arg Arg Lys Glu Gln Leu Glu Arg Leu Tyr Asn Arg Thr Pro Glu Gln
 225                 230                 235                 240
 Val Ala Glu Glu Glu Tyr Leu Leu Gln Glu Leu Arg Lys Ile Glu Ala
                 245                 250                 255    
 Arg Lys Lys Glu Arg Glu Lys Arg Ser Gln Asp Leu Gln Lys Leu Ile
             260                 265                 270        
 Thr Ala Ala Asp Thr Thr Ala Glu Gln Arg Arg Thr Glu Arg Lys Ala
         275                 280                 285            
 Pro Lys Lys Lys Leu Pro Gln Lys Lys Glu Ala Glu Lys Pro Ala Val
     290                 295                 300                
 Pro Glu Thr Ala Gly Ile Lys Phe Pro Asp Phe Lys Ser Ala Gly Val
 305                 310                 315                 320
 Thr Leu Arg Ser Gln Arg Met Lys Leu Pro Ser Ser Val Gly Gln Lys
                 325                 330                 335    
 Lys Ile Lys Ala Leu Glu Gln Met Leu Leu Glu Leu Gly Val Glu Leu
             340                 345                 350        
 Ser Pro Thr Pro Thr Glu Glu Leu Val His Met Phe Asn Glu Leu Arg
         355                 360                 365            
 Ser Asp Leu Val Leu Leu Tyr Glu Leu Lys Gln Ala Cys Ala Asn Cys
     370                 375                 380                
 Glu Tyr Glu Leu Gln Met Leu Arg His Arg His Glu Ala Leu Ala Arg
 385                 390                 395                 400
 Ala Gly Val Leu Gly Gly Pro Ala Thr Pro Ala Ser Gly Pro Gly Pro
                 405                 410                 415    
 Ala Ser Ala Glu Pro Ala Val Thr Glu Pro Gly Leu Gly Pro Asp Pro
             420                 425                 430        
 Lys Asp Thr Ile Ile Asp Val Val Gly Ala Pro Leu Thr Pro Asn Ser
         435                 440                 445            
 Arg Lys Arg Arg Glu Ser Ala Ser Ser Ser Ser Ser Val Lys Lys Ala
     450                 455                 460                
 Lys Lys Pro
 465        



      <210> 293
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 293
 Met Ala Thr Gly Ala Asp Val Arg Asp Ile Leu Glu Leu Gly Gly Pro
   1               5                  10                  15    
 Glu Gly Asp Ala Ala Ser Gly Thr Ile Ser Lys Lys Asp Ile Ile Asn
              20                  25                  30        
 Pro Asp Lys Lys Lys Ser Lys Lys Ser Ser Glu Thr Leu Thr Phe Lys
          35                  40                  45            
 Arg Pro Glu Gly Met His Arg Glu Val Tyr Ala Leu Leu Tyr Ser Asp
      50                  55                  60                
 Lys Lys Asp Ala Pro Pro Leu Leu Pro Ser Asp Thr Gly Gln Gly Tyr
  65                  70                  75                  80
 Arg Thr Val Lys Ala Lys Leu Gly Ser Lys Lys Val Arg Pro Trp Lys
                  85                  90                  95    
 Trp Met Pro Phe Thr Asn Pro Ala Arg Lys Asp Gly Ala Met Phe Phe
             100                 105                 110        
 His Trp Arg Arg Ala Ala Glu Glu Gly Lys Asp Tyr Pro Phe Ala Arg
         115                 120                 125            
 Phe Asn Lys Thr Val Gln Val Pro Val Tyr Ser Glu Gln Glu Tyr Gln
     130                 135                 140                
 Leu Tyr Leu His Asp Asp Ala Trp Thr Lys Ala Glu Thr Asp His Leu
 145                 150                 155                 160
 Phe Asp Leu Ser Arg Arg Phe Asp Leu Arg Phe Val Val Ile His Asp
                 165                 170                 175    
 Arg Tyr Asp His Gln Gln Phe Lys Lys Arg Ser Val Glu Asp Leu Lys
             180                 185                 190        
 Glu Arg Tyr Tyr His Ile Cys Ala Lys Leu Ala Asn Val Arg Ala Val
         195                 200                 205            
 Pro Gly Thr Asp Leu Ala Gly His Glu Arg Arg Arg Lys Glu Gln Leu
     210                 215                 220                
 Glu Arg Leu Tyr Asn Arg Thr Pro Glu Gln Val Ala Glu Glu Glu Tyr
 225                 230                 235                 240
 Leu Leu Gln Glu Leu Arg Lys Ile Pro Val Phe Asp Ala Gly His Glu
                 245                 250                 255    
 Arg Arg Arg Lys Glu Gln Leu Glu Arg Leu Tyr Asn Arg Thr Pro Glu
             260                 265                 270        
 Gln Val Ala Glu Glu Glu Tyr Leu Leu Gln Glu Leu Arg Lys Ile Glu
         275                 280                 285            
 Ala Arg Lys Lys Glu Arg Glu Lys Arg Ser Gln Asp Leu Gln Lys Leu
     290                 295                 300                
 Ile Thr Ala Ala Asp Thr Thr Ala Glu Gln Arg Arg Thr Glu Arg Lys
 305                 310                 315                 320
 Ala Pro Lys Lys Lys Leu Pro Gln Lys Lys Glu Ala Glu Lys Pro Ala
                 325                 330                 335    
 Val Pro Glu Thr Ala Gly Ile Lys Phe Pro Asp Phe Lys Ser Ala Gly
             340                 345                 350        
 Val Thr Leu Arg Ser Gln Arg Met Lys Leu Pro Ser Ser Val Gly Gln
         355                 360                 365            
 Lys Lys Ile Lys Ala Leu Glu Gln Met Leu Leu Glu Leu Gly Val Glu
     370                 375                 380                
 Leu Ser Pro Thr Pro Thr Glu Glu Leu Val His Met Phe Asn Glu Leu
 385                 390                 395                 400
 Arg Ser Asp Leu Val Leu Leu Tyr Glu Leu Lys Gln Ala Cys Ala Asn
                 405                 410                 415    
 Cys Glu Tyr Glu Leu Gln Met Leu Arg His Arg His Glu Ala Leu Ala
             420                 425                 430        
 Arg Ala Gly Val Leu Gly Gly Pro Ala Thr Pro Ala Ser Gly Pro Gly
         435                 440                 445            
 Pro Ala Ser Ala Glu Pro Ala Val Thr Glu Pro Gly Leu Gly Pro Asp
     450                 455                 460                
 Pro Lys Asp Thr Ile Ile Asp Val Val Gly Ala Pro Leu Thr Pro Asn
 465                 470                 475                 480
 Ser Arg Lys Arg Arg Glu Ser Ala Ser Ser Ser Ser Ser Val Lys Lys
                 485                 490                 495    
 Ala Lys Lys Pro
             500



      <210> 294
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 294
 Met Ala Ala Gln Ser Ala Pro Lys Val Val Leu Lys Ser Thr Thr Lys
   1               5                  10                  15    
 Met Ser Leu Asn Glu Arg Phe Thr Asn Met Leu Lys Asn Lys Gln Pro
              20                  25                  30        
 Thr Pro Val Asn Ile Arg Ala Ser Met Gln Gln Gln Gln Gln Leu Ala
          35                  40                  45            
 Ser Ala Arg Asn Arg Arg Leu Ala Gln Gln Met Glu Asn Arg Pro Ser
      50                  55                  60                
 Val Gln Ala Ala Leu Lys Leu Lys Gln Lys Ser Leu Lys Gln Arg Leu
  65                  70                  75                  80
 Gly Lys Ser Asn Ile Gln Ala Arg Leu Gly Arg Pro Ile Gly Ala Leu
                  85                  90                  95    
 Ala Arg Gly Ala Ile Gly Gly Arg Gly Leu Pro Ile Ile Gln Arg Gly
             100                 105                 110        
 Leu Pro Arg Gly Gly Leu Arg Gly Gly Arg Ala Thr Arg Thr Leu Leu
         115                 120                 125            
 Arg Gly Gly Met Ser Leu Arg Gly Gln Asn Leu Leu Arg Gly Gly Arg
     130                 135                 140                
 Ala Val Ala Pro Arg Met Gly Leu Arg Arg Gly Gly Val Arg Gly Arg
 145                 150                 155                 160
 Gly Gly Pro Gly Arg Gly Gly Leu Gly Arg Gly Ala Met Gly Arg Gly
                 165                 170                 175    
 Gly Ile Gly Gly Arg Gly Arg Gly Met Ile Gly Arg Gly Arg Gly Gly
             180                 185                 190        
 Phe Gly Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Ala Leu Ala
         195                 200                 205            
 Arg Pro Val Leu Thr Lys Glu Gln Leu Asp Asn Gln Leu Asp Ala Tyr
     210                 215                 220                
 Met Ser Lys Thr Lys Gly His Leu Asp Ala Glu Leu Asp Ala Tyr Met
 225                 230                 235                 240
 Ala Gln Thr Asp Pro Glu Thr Asn Asp
                 245                



      <210> 295
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 295
 Met Ser Ala Glu Val Lys Val Thr Gly Gln Asn Gln Glu Gln Phe Leu
   1               5                  10                  15    
 Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala Leu Ala Thr Leu Ile His
              20                  25                  30        
 Gln Val Leu Glu Ala Pro Gly Val Tyr Val Phe Gly Glu Leu Leu Asp
          35                  40                  45            
 Met Pro Asn Val Arg Glu Leu Ala Glu Ser Asp Phe Ala Ser Thr Phe
      50                  55                  60                
 Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr Tyr Ala Asp Tyr Leu Ala
  65                  70                  75                  80
 Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu Ala Gln Lys Asn Lys Leu
                  85                  90                  95    
 Arg His Leu Ser Val Val Thr Leu Ala Ala Lys Val Lys Cys Ile Pro
             100                 105                 110        
 Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu Arg Asn Val Arg Gln Leu
         115                 120                 125            
 Glu Asp Leu Val Ile Glu Ala Val Tyr Ala Asp Val Leu Arg Gly Ser
     130                 135                 140                
 Leu Asp Gln Arg Asn Gln Arg Leu Glu Val Asp Tyr Ser Ile Gly Arg
 145                 150                 155                 160
 Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile Ala Arg Thr Leu Gln Glu
                 165                 170                 175    
 Trp Cys Val Gly Cys Glu Val Val Leu Ser Gly Ile Glu Glu Gln Val
             180                 185                 190        
 Ser Arg Ala Asn Gln His Lys Glu Gln Gln Leu Gly Leu Lys Gln Gln
         195                 200                 205            
 Ile Glu Ser Glu Val Ala Asn Leu Lys Lys Thr Ile Lys Val Thr Thr
     210                 215                 220                
 Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp Pro Glu Gln His Leu Thr
 225                 230                 235                 240
 Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn Gln Arg Gln Pro Ser Lys
                 245                 250                 255    
 Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly Ser Ala Lys Ile Trp Ser
             260                 265                 270        
 Lys Ser Asn
         275



      <210> 296
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 296
 Met Ala Arg Tyr Glu Glu Val Ser Val Ser Gly Phe Glu Glu Phe His
   1               5                  10                  15    
 Arg Ala Val Glu Gln His Asn Gly Lys Thr Ile Phe Ala Tyr Phe Thr
              20                  25                  30        
 Gly Ser Lys Asp Ala Gly Gly Lys Ser Trp Cys Pro Asp Cys Val Gln
          35                  40                  45            
 Ala Glu Pro Val Val Arg Glu Gly Leu Lys His Ile Ser Glu Gly Cys
      50                  55                  60                
 Val Phe Ile Tyr Cys Gln Val Gly Glu Lys Pro Tyr Trp Lys Asp Pro
  65                  70                  75                  80
 Asn Asn Asp Phe Arg Lys Asn Leu Lys Val Thr Ala Val Pro Thr Leu
                  85                  90                  95    
 Leu Lys Tyr Gly Thr Pro Gln Lys Leu Val Glu Ser Glu Cys Leu Gln
             100                 105                 110        
 Ala Asn Leu Val Glu Met Leu Phe Ser Glu Asp
         115                 120            



      <210> 297
      <211> 51
      <212> PRT
      <213> Homo sapiens


      <400> 297
 Met Ala His Cys Ser Leu Asn Leu Leu Gly Ser Ser Asn Pro Pro Ala
   1               5                  10                  15    
 Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Ala Cys His His Thr Ser
              20                  25                  30        
 Leu Ile Phe Pro Phe Val Leu Tyr Val Asp Ser Thr Gly Leu Thr Leu
          35                  40                  45            
 Lys Thr
      50



      <210> 298
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 298
 Met Pro Leu Ile Tyr Ile Asn Ile Ile Leu Ala Phe Thr Ile Ser Leu
   1               5                  10                  15    
 Leu Gly Ile Leu Val Tyr Arg Ser His Leu Ile Ser Ser Leu Leu Cys
              20                  25                  30        
 Leu Glu Gly Ile Ile Leu Ser Leu Phe Ile Ile Ala Thr Leu Ile Thr
          35                  40                  45            
 Leu Asn Thr His Ser Leu Leu Ala Asn Ile Val Pro Ile Ala Ile Leu
      50                  55                  60                
 Val Phe Ala Ala Cys Glu Ala Ala Val Gly Leu Ala Leu Leu Val Ser
  65                  70                  75                  80
 Ile Ser Asn Thr Tyr Gly Leu Asp Tyr Val His Asn Leu Asn Leu Leu
                  85                  90                  95    
 Gln Cys
        



      <210> 299
      <211> 369
      <212> PRT
      <213> Homo sapiens


      <400> 299
 Met Cys Ser Leu Pro Arg Gly Phe Glu Pro Gln Ala Pro Glu Asp Leu
   1               5                  10                  15    
 Ala Gln Arg Ser Leu Val Glu Leu Arg Glu Met Leu Lys Arg Gln Glu
              20                  25                  30        
 Arg Leu Leu Arg Asn Glu Lys Phe Ile Cys Lys Leu Pro Asp Lys Gly
          35                  40                  45            
 Lys Lys Ile Phe Asp Ser Phe Ala Lys Leu Lys Ala Ala Ile Ala Glu
      50                  55                  60                
 Cys Glu Glu Val Arg Arg Lys Ser Glu Leu Phe Asn Pro Val Ser Leu
  65                  70                  75                  80
 Asp Cys Lys Leu Arg Gln Lys Ala Ile Ala Glu Val Asp Val Gly Thr
                  85                  90                  95    
 Asp Lys Ala Gln Asn Ser Asp Pro Ile Leu Asp Thr Ser Ser Leu Val
             100                 105                 110        
 Pro Gly Cys Ser Ser Val Asp Asn Ile Lys Ser Ser Gln Thr Ser Gln
         115                 120                 125            
 Asn Gln Gly Leu Gly Arg Pro Thr Leu Glu Gly Asp Glu Glu Thr Ser
     130                 135                 140                
 Glu Val Glu Tyr Thr Val Asn Lys Gly Pro Ala Ser Ser Asn Arg Asp
 145                 150                 155                 160
 Arg Val Pro Pro Ser Ser Glu Ala Ser Glu His His Pro Arg His Arg
                 165                 170                 175    
 Val Ser Ser Gln Ala Glu Asp Thr Ser Ser Ser Phe Asp Asn Leu Phe
             180                 185                 190        
 Ile Asp Arg Leu Gln Arg Ile Thr Ile Ala Asp Gln Gly Glu Gln Gln
         195                 200                 205            
 Ser Glu Glu Asn Ala Ser Thr Lys Asn Leu Thr Gly Leu Ser Ser Gly
     210                 215                 220                
 Thr Glu Lys Lys Pro His Tyr Met Glu Val Leu Glu Met Arg Ala Lys
 225                 230                 235                 240
 Asn Pro Val Pro Gln Leu Arg Lys Phe Lys Thr Asn Val Leu Pro Phe
                 245                 250                 255    
 Arg Gln Asn Asp Ser Ser Ser His Cys Gln Lys Ser Gly Ser Pro Ile
             260                 265                 270        
 Ser Ser Glu Glu Arg Arg Arg Arg Asp Lys Gln His Leu Asp Asp Ile
         275                 280                 285            
 Thr Ala Ala Arg Leu Leu Pro Leu His His Met Pro Thr Gln Leu Leu
     290                 295                 300                
 Ser Ile Glu Glu Ser Leu Ala Leu Gln Lys Gln Gln Lys Gln Asn Tyr
 305                 310                 315                 320
 Glu Glu Met Gln Ala Lys Leu Ala Ala Gln Lys Leu Ala Glu Arg Leu
                 325                 330                 335    
 Asn Ile Lys Met Arg Ser Tyr Asn Pro Glu Gly Glu Ser Ser Gly Arg
             340                 345                 350        
 Tyr Arg Glu Val Arg Asp Glu Asp Asp Asp Trp Ser Ser Asp Glu Phe
         355                 360                 365            





      <210> 300
      <211> 538
      <212> PRT
      <213> Homo sapiens


      <400> 300
 Met Phe Asn Ser Arg Ile Leu Thr Lys Tyr Thr Leu Leu Leu Gly Gln
   1               5                  10                  15    
 Asp Glu Asn Ser Val Ile Lys Ser Phe Thr Ala Ser Val Asp Arg Lys
              20                  25                  30        
 Phe Ile Ser Leu Met Ser Leu Ser Ser Asp Gly Cys Ile Tyr Glu Thr
          35                  40                  45            
 Leu Ile Pro Ile Arg Pro Ala Asp Pro Glu Lys Asn Gln Ser Leu Val
      50                  55                  60                
 Lys Ser Leu Leu Leu Lys Ala Val Val Ser Gly Asn Ala Arg Asn Gly
  65                  70                  75                  80
 Val Ala Leu Thr Ala Leu Asp Gln Asp His Val Ala Val Leu Gly Ser
                  85                  90                  95    
 Pro Leu Ala Ala Ser Lys Glu Cys Leu Ser Val Trp Asn Ile Lys Phe
             100                 105                 110        
 Gln Thr Leu Gln Thr Ser Lys Glu Leu Pro Gln Gly Thr Ser Gly Gln
         115                 120                 125            
 Leu Trp Tyr Tyr Gly Glu His Leu Phe Met Leu His Gly Lys Ser Leu
     130                 135                 140                
 Thr Val Ile Pro Tyr Lys Cys Glu Val Ser Ser Leu Ala Gly Ala Leu
 145                 150                 155                 160
 Gly Lys Leu Lys His Ser Gln Asp Pro Gly Thr His Val Val Ser His
                 165                 170                 175    
 Phe Val Asn Trp Glu Thr Pro Gln Gly Cys Gly Leu Gly Phe Gln Asn
             180                 185                 190        
 Ser Glu Gln Ser Arg Arg Ile Leu Arg Arg Arg Lys Ile Glu Val Ser
         195                 200                 205            
 Leu Gln Pro Glu Val Pro Pro Ser Lys Gln Leu Leu Ser Thr Ile Met
     210                 215                 220                
 Lys Asp Ser Glu Lys His Ile Glu Val Glu Val Arg Lys Phe Leu Ala
 225                 230                 235                 240
 Leu Lys Gln Thr Pro Asp Phe His Thr Val Ile Gly Asp Thr Val Thr
                 245                 250                 255    
 Gly Leu Leu Glu Arg Cys Lys Ala Glu Pro Ser Phe Tyr Pro Arg Asn
             260                 265                 270        
 Cys Leu Met Gln Leu Ile Gln Thr His Val Leu Ser Tyr Ser Leu Cys
         275                 280                 285            
 Pro Asp Leu Met Glu Ile Ala Leu Lys Lys Lys Asp Val Gln Leu Leu
     290                 295                 300                
 Gln Leu Cys Leu Gln Gln Phe Pro Asp Ile Pro Glu Ser Val Thr Cys
 305                 310                 315                 320
 Ala Cys Leu Lys Ile Phe Leu Ser Ile Gly Asp Asp Ser Leu Gln Glu
                 325                 330                 335    
 Thr Asp Val Asn Met Glu Ser Val Phe Asp Tyr Ser Ile Asn Ser Val
             340                 345                 350        
 His Asp Glu Lys Met Glu Glu Gln Thr Glu Ile Leu Gln Asn Gly Phe
         355                 360                 365            
 Asn Pro Glu Glu Asp Lys Cys Asn Asn Cys Asp Gln Glu Leu Asn Lys
     370                 375                 380                
 Lys Pro Gln Asp Glu Thr Lys Glu Ser Thr Ser Cys Pro Val Val Gln
 385                 390                 395                 400
 Lys Arg Ala Ala Leu Leu Asn Ala Ile Leu His Ser Ala Tyr Ser Glu
                 405                 410                 415    
 Thr Phe Leu Leu Pro His Leu Lys Asp Ile Pro Ala Gln His Ile Thr
             420                 425                 430        
 Leu Phe Leu Lys Tyr Leu Tyr Phe Leu Tyr Leu Lys Cys Ser Glu Asn
         435                 440                 445            
 Ala Thr Met Thr Leu Pro Gly Ile His Pro Pro Thr Leu Asn Gln Ile
     450                 455                 460                
 Met Asp Trp Ile Cys Leu Leu Leu Asp Ala Asn Phe Thr Val Val Val
 465                 470                 475                 480
 Met Met Pro Glu Ala Lys Arg Leu Leu Ile Asn Leu Tyr Lys Leu Val
                 485                 490                 495    
 Lys Ser Gln Ile Ser Val Tyr Ser Glu Leu Asn Lys Ile Glu Val Ser
             500                 505                 510        
 Phe Arg Glu Leu Gln Lys Leu Asn Gln Glu Lys Asn Asn Arg Gly Leu
         515                 520                 525            
 Tyr Ser Ile Glu Val Leu Glu Leu Phe
     530                 535        



      <210> 301
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 301
 Met Lys Thr Phe Arg Trp Lys Val Lys Pro Gly Met Asp Val Ala Ser
   1               5                  10                  15    
 Val Pro Ser Val Arg Lys Val Arg Phe Gly Asp Gly Tyr Ser Gln Arg
              20                  25                  30        
 Ala Pro Ala Gly Leu Asn Ala Asn Leu Lys Thr Tyr Ser Val Thr Leu
          35                  40                  45            
 Ser Val Pro Arg Glu Glu Ala Thr Val Leu Glu Ser Phe Leu Glu Glu
      50                  55                  60                
 His Gly Gly Trp Lys Ser Phe Leu Trp Thr Pro Pro Tyr Glu Trp Arg
  65                  70                  75                  80
 Gln Ile Lys Val Thr Cys Ala Lys Trp Ser Ser Arg Val Ser Met Leu
                  85                  90                  95    
 Arg Val Glu Phe Ser Ala Glu Phe Glu Gln Val Val Asn
             100                 105                



      <210> 302
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 302
 Met Arg Pro Leu Asp Ile Asp Glu Val Glu Ala Pro Glu Glu Val Glu
   1               5                  10                  15    
 Val Leu Glu Pro Glu Glu Asp Phe Glu Gln Phe Leu Leu Pro Val Ile
              20                  25                  30        
 Asn Glu Met Arg Glu Asp Ile Ala Ser Leu Ile Arg Glu His Gly Arg
          35                  40                  45            
 Ala Tyr Leu Arg Thr Arg Ser Lys Leu Trp Glu Met Asp Asn Met Leu
      50                  55                  60                
 Ile Gln Ile Lys Thr Gln Val Glu Ala Ser Glu Glu Ser Ala Leu Asn
  65                  70                  75                  80
 His Val Gln His Pro Ser Gly Glu Ala Asp Glu Arg Val Ser Glu Leu
                  85                  90                  95    
 Cys Glu Lys Ala Glu Glu Lys Ala Lys Glu Ile Ala Lys Met Ala Glu
             100                 105                 110        
 Met Leu Val Glu Leu Val Trp Arg Ile Glu Arg Ser Glu Ser Ser
         115                 120                 125        



      <210> 303
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 303
 Met Ala Lys Asp Ile Leu Gly Glu Ala Gly Leu His Phe Asp Glu Leu
   1               5                  10                  15    
 Asn Lys Leu Arg Val Leu Asp Pro Glu Val Thr Gln Gln Thr Ile Glu
              20                  25                  30        
 Leu Lys Glu Glu Cys Lys Asp Phe Val Asp Lys Ile Gly Gln Phe Gln
          35                  40                  45            
 Lys Ile Val Gly Gly Leu Ile Glu Leu Val Asp Gln Leu Ala Lys Glu
      50                  55                  60                
 Ala Glu Asn Glu Lys Met Lys Ala Ile Gly Ala Arg Asn Leu Leu Lys
  65                  70                  75                  80
 Ser Ile Ala Lys Gln Arg Glu Ala Gln Gln Gln Gln Leu Gln Ala Leu
                  85                  90                  95    
 Ile Ala Glu Lys Lys Met Gln Leu Glu Arg Tyr Arg Val Glu Tyr Glu
             100                 105                 110        
 Ala Leu Cys Lys Val Glu Ala Glu Gln Asn Glu Phe Ile Asp Gln Phe
         115                 120                 125            
 Ile Phe Gln Lys
     130        



      <210> 304
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 304
 Met Gln Asp Pro Asn Ala Asp Thr Glu Trp Asn Asp Ile Leu Arg Lys
   1               5                  10                  15    
 Lys Gly Ile Leu Pro Pro Lys Glu Ser Leu Lys Glu Leu Glu Glu Glu
              20                  25                  30        
 Ala Glu Glu Glu Gln Arg Ile Leu Gln Gln Ser Val Val Lys Thr Tyr
          35                  40                  45            
 Glu Asp Met Thr Leu Glu Glu Leu Glu Asp His Glu Asp Glu Phe Asn
      50                  55                  60                
 Glu Glu Asp Glu Arg Ala Ile Glu Met Tyr Arg Arg Arg Arg Leu Ala
  65                  70                  75                  80
 Glu Trp Lys Ala Thr Lys Leu Lys Asn Lys Phe Gly Glu Val Leu Glu
                  85                  90                  95    
 Ile Ser Gly Lys Asp Tyr Val Gln Glu Val Thr Lys Ala Gly Glu Gly
             100                 105                 110        
 Leu Trp Val Ile Leu His Leu Tyr Lys Gln Gly Ile Pro Leu Cys Ala
         115                 120                 125            
 Leu Ile Asn Gln His Leu Ser Gly Leu Ala Arg Lys Phe Pro Asp Val
     130                 135                 140                
 Lys Phe Ile Lys Ala Ile Ser Thr Thr Cys Ile Pro Asn Tyr Pro Asp
 145                 150                 155                 160
 Arg Asn Leu Pro Thr Ile Phe Val Tyr Leu Glu Gly Asp Ile Lys Ala
                 165                 170                 175    
 Gln Phe Ile Gly Pro Leu Val Phe Gly Gly Met Asn Leu Thr Arg Asp
             180                 185                 190        
 Glu Leu Glu Trp Lys Leu Ser Glu Ser Gly Ala Ile Met Thr Asp Leu
         195                 200                 205            
 Glu Glu Asn Pro Lys Lys Pro Ile Glu Asp Val Leu Leu Ser Ser Val
     210                 215                 220                
 Arg Arg Ser Val Leu Met Lys Arg Asp Ser Asp Ser Glu Gly Asp
 225                 230                 235                



      <210> 305
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 305
 Met Thr Arg Gln Glu Glu Leu Ala Ala Ala Arg Ala Ala Leu His Asp
   1               5                  10                  15    
 Leu Met Thr Gly Lys Arg Val Ala Thr Val Gln Lys Asp Gly Arg Arg
              20                  25                  30        
 Val Glu Phe Thr Ala Thr Ser Val Ser Asp Leu Lys Lys Tyr Ile Ala
          35                  40                  45            
 Glu Leu Glu Val Gln Thr Gly Met Thr Gln Arg Arg Arg Gly Pro Ala
      50                  55                  60                
 Gly Phe Tyr Val
  65            



      <210> 306
      <211> 40
      <212> PRT
      <213> Homo sapiens


      <400> 306
 Met Phe Gly Asp Asp Cys His Gln Leu Cys Asp Cys Glu Gly Glu Thr
   1               5                  10                  15    
 Phe Cys His Pro Lys Thr Glu Lys Cys Leu Cys Pro Arg Gly Arg Thr
              20                  25                  30        
 Gly Ala Arg Cys Asp Ala Gly
          35                



      <210> 307
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 307
 Met Thr Thr Ala Thr Arg Gln Glu Val Leu Gly Leu Tyr Arg Ser Ile
   1               5                  10                  15    
 Phe Arg Leu Ala Arg Lys Trp Gln Ala Thr Ser Gly Gln Met Glu Asp
              20                  25                  30        
 Thr Ile Lys Glu Lys Gln Tyr Ile Leu Asn Glu Ala Arg Thr Leu Phe
          35                  40                  45            
 Arg Lys Asn Lys Asn Leu Thr Asp Thr Asp Leu Ile Lys Gln Cys Ile
      50                  55                  60                
 Asp Glu Cys Thr Ala Arg Ile Glu Ile Gly Leu His Tyr Lys Ile Pro
  65                  70                  75                  80
 Tyr Pro Arg Pro Ile His Leu Pro Pro Met Gly Leu Thr Pro Leu Arg
                  85                  90                  95    
 Gly Arg Gly Leu Arg Ser Gln Glu Lys Leu Arg Lys Leu Ser Lys Pro
             100                 105                 110        
 Val Tyr Leu Arg Ser His Asp Glu Val Ser
         115                 120        



      <210> 308
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 308
 Met Ala Pro Pro Arg Ile Gly Thr His Asn Gly Thr Phe His Cys Asp
   1               5                  10                  15    
 Glu Ala Leu Ala Cys Ala Leu Leu Arg Leu Leu Pro Glu Tyr Arg Asp
              20                  25                  30        
 Ala Glu Ile Val Arg Thr Arg Asp Pro Glu Lys Leu Ala Ser Cys Asp
          35                  40                  45            
 Ile Val Val Asp Val Gly Gly Glu Tyr His Pro Arg Arg His Arg Tyr
      50                  55                  60                
 Asp His His Gln Arg Ser Phe Thr Glu Thr Met Ser Ser Leu Ser Pro
  65                  70                  75                  80
 Gly Lys Pro Trp Gln Thr Lys Leu Ser Ser Ala Gly Leu Ile Tyr Leu
                  85                  90                  95    
 His Phe Gly His Lys Leu Leu Ala Gln Leu Leu Gly Thr Ser Glu Glu
             100                 105                 110        
 Asp Ser Met Val Gly Thr Leu Tyr Asp Lys Met Tyr Glu Asn Phe Val
         115                 120                 125            
 Glu Glu Val Asp Ala Val Asp Asn Gly Ile Ser Gln Trp Ala Glu Gly
     130                 135                 140                
 Glu Pro Arg Tyr Ala Leu Thr Thr Thr Leu Ser Ala Arg Val Ala Arg
 145                 150                 155                 160
 Leu Asn Pro Thr Trp Asn His Pro Asp Gln Asp Thr Glu Ala Gly Phe
                 165                 170                 175    
 Lys Arg Ala Met Asp Leu Val Gln Glu Glu Phe Leu Gln Arg Leu Asp
             180                 185                 190        
 Phe Tyr Gln His Ser Trp Leu Pro Ala Arg Ala Leu Val Glu Glu Ala
         195                 200                 205            
 Leu Ala Gln Arg Phe Gln Val Asp Pro Ser Gly Glu Ile Val Glu Leu
     210                 215                 220                
 Ala Lys Gly Ala Cys Pro Trp Lys Glu His Leu Tyr His Leu Glu Ser
 225                 230                 235                 240
 Gly Leu Ser Pro Pro Val Ala Ile Phe Phe Val Ile Tyr Thr Asp Gln
                 245                 250                 255    
 Ala Gly Gln Trp Arg Ile Gln Cys Val Pro Lys Glu Pro His Ser Phe
             260                 265                 270        
 Gln Ser Arg Leu Pro Leu Pro Glu Pro Trp Arg Gly Leu Arg Asp Glu
         275                 280                 285            
 Ala Leu Asp Gln Val Ser Gly Ile Pro Gly Cys Ile Phe Val His Ala
     290                 295                 300                
 Ser Gly Phe Ile Gly Gly His Arg Thr Arg Glu Gly Ala Leu Ser Met
 305                 310                 315                 320
 Ala Arg Ala Thr Leu Ala Gln Arg Ser Tyr Leu Pro Gln Ile Ser
                 325                 330                 335



      <210> 309
      <211> 427
      <212> PRT
      <213> Homo sapiens


      <400> 309
 Met Asn Ser Val Tyr Ser Tyr His Ser Tyr Tyr Ala Gln Pro Ser Leu
   1               5                  10                  15    
 Thr Ser Val Asn Gly Phe His Ser Lys Tyr Ala Leu Pro Ser Phe Ser
              20                  25                  30        
 Tyr Cys Gly Phe Pro Ser Ser Asn Pro Val Phe Pro Ser Gln Phe Leu
          35                  40                  45            
 Gly Pro Gly Ala Trp Gly His Ser Gly Ser Ser Gly Ser Phe Glu Lys
      50                  55                  60                
 Lys Pro Asp Leu His Ala Leu His Asn Ser Leu Ser Pro Ala Tyr Gly
  65                  70                  75                  80
 Gly Ala Glu Phe Ala Glu Leu Pro Ser Gln Ala Val Pro Thr Asp Ala
                  85                  90                  95    
 His His Pro Thr Pro His His Gln Gln Pro Ala Tyr Pro Gly Pro Lys
             100                 105                 110        
 Glu Tyr Leu Leu Pro Lys Ala Pro Leu Leu His Ser Val Ser Arg Asp
         115                 120                 125            
 Pro Ser Pro Phe Ala Gln Ser Ser Asn Cys Tyr Asn Arg Ser Ile Lys
     130                 135                 140                
 Gln Glu Pro Val Asp Pro Leu Thr Gln Ala Glu Pro Val Pro Arg Asp
 145                 150                 155                 160
 Ala Gly Lys Met Gly Lys Thr Pro Leu Ser Glu Val Ser Gln Asn Gly
                 165                 170                 175    
 Gly Pro Ser His Leu Trp Gly Gln Tyr Ser Gly Gly Pro Ser Met Ser
             180                 185                 190        
 Pro Lys Arg Thr Asn Gly Val Gly Gly Ser Trp Gly Val Phe Ser Ser
         195                 200                 205            
 Gly Glu Ser Pro Ala Ile Val Pro Asp Lys Leu Ser Ser Phe Gly Ala
     210                 215                 220                
 Ser Cys Leu Ala Pro Ser His Phe Thr Asp Gly Gln Trp Gly Leu Phe
 225                 230                 235                 240
 Pro Gly Glu Gly Gln Gln Ala Ala Ser His Ser Gly Gly Arg Leu Arg
                 245                 250                 255    
 Gly Lys Pro Trp Ser Pro Cys Lys Phe Gly Asn Ser Thr Ser Ala Leu
             260                 265                 270        
 Ala Gly Pro Ser Leu Thr Glu Lys Pro Trp Ala Leu Gly Ala Gly Asp
         275                 280                 285            
 Phe Asn Ser Ala Leu Lys Gly Ser Pro Gly Phe Gln Asp Lys Leu Trp
     290                 295                 300                
 Asn Pro Met Lys Gly Glu Glu Gly Arg Ile Pro Ala Ala Gly Ala Ser
 305                 310                 315                 320
 Gln Leu Val Phe Tyr Gln His Lys Asn Leu Asn Gln Pro Asn His Gly
                 325                 330                 335    
 Leu Ala Leu Trp Glu Ala Lys Met Lys Gln Leu Ala Glu Arg Ala Arg
             340                 345                 350        
 Ala Arg Gln Glu Glu Ala Ala Arg Leu Gly Leu Gly Gln Gln Glu Ala
         355                 360                 365            
 Lys Leu Tyr Gly Lys Lys Arg Lys Trp Gly Gly Thr Val Val Ala Glu
     370                 375                 380                
 Pro Gln Gln Lys Glu Lys Lys Gly Val Val Pro Thr Arg Gln Ala Leu
 385                 390                 395                 400
 Ala Val Pro Thr Asp Ser Ala Val Thr Val Ser Ser Tyr Ala Tyr Thr
                 405                 410                 415    
 Lys Val Thr Gly Pro Tyr Ser Arg Trp Ile
             420                 425    



      <210> 310
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 310
 Met Cys Ser Glu Ile Ile Leu Arg Gln Glu Val Leu Lys Asp Gly Phe
   1               5                  10                  15    
 His Arg Asp Leu Leu Ile Lys Val Lys Phe Gly Glu Ser Ile Glu Asp
              20                  25                  30        
 Leu His Thr Cys Arg Leu Leu Ile Lys Gln Asp Ile Pro Ala Gly Leu
          35                  40                  45            
 Tyr Val Asp Pro Tyr Glu Leu Ala Ser Leu Arg Glu Arg Asn Ile Thr
      50                  55                  60                
 Glu Ala Val Met Val Ser Glu Asn Phe Asp Ile Glu Ala Pro Asn Tyr
  65                  70                  75                  80
 Leu Ser Lys Glu Ser Glu Val Leu Ile Tyr Ala Arg Arg Asp Ser Gln
                  85                  90                  95    
 Cys Ile Asp Cys Phe Gln Ala Phe Leu Pro Val His Cys Arg Tyr His
             100                 105                 110        
 Arg Pro His Ser Glu Asp Gly Glu Ala Ser Ile Val Val Asn Asn Pro
         115                 120                 125            
 Asp Leu Leu Met Phe Cys Asp Gln Glu Phe Pro Ile Leu Lys Cys Trp
     130                 135                 140                
 Ala His Ser Glu Val Ala Ala Pro Cys Ala Leu Glu Asn Glu Asp Ile
 145                 150                 155                 160
 Cys Gln Trp Asn Lys Met Lys Tyr Lys Ser Val Tyr Lys Asn Val Ile
                 165                 170                 175    
 Leu Gln Val Pro Val Gly Leu Thr Val His Thr Ser Leu Val Cys Ser
             180                 185                 190        
 Val Thr Leu Leu Ile Thr Ile Leu Cys Ser Thr Leu Ile Leu Val Ala
         195                 200                 205            
 Val Phe Lys Tyr Gly His Phe Ser Leu
     210                 215        



      <210> 311
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 311
 Met Trp Lys Pro Met Pro Ser Pro Ser Asn Met Lys Ala Ser Ala Ala
   1               5                  10                  15    
 Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala Phe Ser Pro Gln Gly Leu
              20                  25                  30        
 Ala Gln Pro Val Gly Ile Asn Thr Ser Thr Thr Cys Cys Tyr Arg Phe
          35                  40                  45            
 Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu Glu Ser Tyr Arg Arg Thr
      50                  55                  60                
 Thr Ser Ser His Cys Pro Arg Glu Ala Val Ile Phe Lys Thr Lys Leu
  65                  70                  75                  80
 Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln Lys Trp Val Gln Asp Phe
                  85                  90                  95    
 Met Lys His Leu Asp Lys Lys Thr Gln Thr Pro Lys Leu
             100                 105                



      <210> 312
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 312
 Met Lys Leu Ile Val Gly Ile Gly Gly Met Thr Asn Gly Gly Lys Thr
   1               5                  10                  15    
 Thr Leu Thr Asn Ser Leu Leu Arg Ala Leu Pro Asn Cys Cys Val Ile
              20                  25                  30        
 His Gln Asp Asp Phe Phe Lys Pro Gln Asp Gln Ile Ala Val Gly Glu
          35                  40                  45            
 Asp Gly Phe Lys Gln Trp Asp Val Leu Glu Ser Leu Asp Met Glu Ala
      50                  55                  60                
 Met Leu Asp Thr Val Gln Ala Trp Leu Ser Ser Pro Gln Lys Phe Ala
  65                  70                  75                  80
 Arg Ala His Gly Val Ser Val Gln Pro Glu Ala Ser Asp Thr His Ile
                  85                  90                  95    
 Leu Leu Leu Glu Gly Phe Leu Leu Tyr Ser Tyr Asn Thr Arg Asn Tyr
             100                 105                 110        
 Thr Val Pro Asp Pro Pro Gly Leu Phe Asp Gly His Val Trp Pro Met
         115                 120                 125            
 Tyr Gln Lys Tyr Arg Gln Glu Met Glu Ala Asn Gly Val Glu Val Val
     130                 135                 140                
 Tyr Leu Asp Gly Met Lys Ser Arg Glu Glu Leu Phe Arg Glu Val Leu
 145                 150                 155                 160
 Glu Asp Ile Gln Asn Ser Leu Leu Asn Arg Ser Gln Glu Ser Ala Pro
                 165                 170                 175    
 Ser Pro Ala Arg Pro Ala Arg Thr Gln Gly Pro Gly Arg Gly Cys Gly
             180                 185                 190        
 His Arg Thr Ala Arg Pro Ala Ala Ser Gln Gln Asp Ser Met
         195                 200                 205    



      <210> 313
      <211> 194
      <212> PRT
      <213> Homo sapiens


      <400> 313
 Met Ser Ser Ile Gly Thr Gly Tyr Asp Leu Ser Ala Ser Thr Phe Ser
   1               5                  10                  15    
 Pro Asp Gly Arg Val Phe Gln Val Glu Tyr Ala Met Lys Ala Val Glu
              20                  25                  30        
 Asn Ser Ser Thr Ala Ile Gly Ile Arg Cys Lys Asp Gly Val Val Phe
          35                  40                  45            
 Gly Val Glu Lys Leu Val Leu Ser Lys Leu Tyr Glu Glu Gly Ser Asn
      50                  55                  60                
 Lys Arg Leu Phe Asn Val Asp Arg His Val Gly Met Ala Val Ala Gly
  65                  70                  75                  80
 Leu Leu Ala Asp Ala Arg Ser Leu Ala Asp Ile Ala Arg Glu Glu Ala
                  85                  90                  95    
 Ser Asn Phe Arg Ser Asn Phe Gly Tyr Asn Ile Pro Leu Lys His Leu
             100                 105                 110        
 Ala Asp Arg Val Ala Met Tyr Val His Ala Tyr Thr Leu Tyr Ser Ala
         115                 120                 125            
 Val Arg Pro Phe Gly Cys Arg Ile Tyr Ile Val His Asp Glu Val Lys
     130                 135                 140                
 Asp Lys Ala Phe Glu Leu Glu Leu Ser Trp Val Gly Glu Leu Thr Asn
 145                 150                 155                 160
 Gly Arg His Glu Ile Val Pro Lys Asp Ile Arg Glu Glu Ala Glu Lys
                 165                 170                 175    
 Tyr Ala Lys Glu Ser Leu Lys Glu Glu Asp Glu Ser Asp Asp Asp Asn
             180                 185                 190        
 Met
    



      <210> 314
      <211> 723
      <212> PRT
      <213> Homo sapiens


      <400> 314
 Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala Ser Val Ala Leu
   1               5                  10                  15    
 Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser Pro Gln Arg Val
              20                  25                  30        
 Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala Gln Met Gln Pro
          35                  40                  45            
 Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln Val Gln Pro Val
      50                  55                  60                
 Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Gly Asp Ala
  65                  70                  75                  80
 Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr Tyr Asn Pro Glu
                  85                  90                  95    
 Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr Phe Glu Ala Pro
             100                 105                 110        
 Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro Pro Ala Val Pro
         115                 120                 125            
 Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly Gly Ser Pro Ile
     130                 135                 140                
 Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly Met Asp Ser Thr
 145                 150                 155                 160
 Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro Ala Thr Leu Glu
                 165                 170                 175    
 Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys
             180                 185                 190        
 Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu
         195                 200                 205            
 Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr
     210                 215                 220                
 Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser
 225                 230                 235                 240
 Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg
                 245                 250                 255    
 Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Leu
             260                 265                 270        
 Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Thr Gln Tyr Met
         275                 280                 285            
 Ala Met Arg Gln Gln Pro Met His Gln Lys Pro Arg Tyr Arg Pro Ala
     290                 295                 300                
 Gln Lys Thr Asp Ser Leu Gly Asp Ser Gly Ser His Ser Gly Leu His
 305                 310                 315                 320
 Ser Thr Pro Glu Gln Thr Met Ala Val Gln Ser Gln His His Gln Gln
                 325                 330                 335    
 Tyr Ile Asp Val Ser His Val Phe Pro Glu Phe Pro Ala Pro Asp Leu
             340                 345                 350        
 Gly Ser Phe Leu Leu Gln Asp Gly Val Thr Leu His Asp Val Lys Ala
         355                 360                 365            
 Leu Gln Leu Val Tyr Arg Arg His Cys Glu Ala Thr Val Asp Val Val
     370                 375                 380                
 Met Asn Leu Gln Phe His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp
 385                 390                 395                 400
 Asn Ser Lys Ala Ser Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser
                 405                 410                 415    
 Asp Glu Asp Pro Glu Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser
             420                 425                 430        
 Leu Cys Gln Cys Asp Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His
         435                 440                 445            
 Ile Leu Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg
     450                 455                 460                
 Pro Val Pro Ser Thr Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser
 465                 470                 475                 480
 Leu Glu Gly Trp Leu Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val
                 485                 490                 495    
 Ile Gln Thr Lys Val Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg
             500                 505                 510        
 Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu
         515                 520                 525            
 Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val
     530                 535                 540                
 Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu
 545                 550                 555                 560
 Glu Ser Val Val Gln Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln
                 565                 570                 575    
 Gln Gln Ser Ser Leu Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val
             580                 585                 590        
 Thr Gln Val Leu Lys Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala
         595                 600                 605            
 Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile
     610                 615                 620                
 Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu
 625                 630                 635                 640
 Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg
                 645                 650                 655    
 Val Ala Glu Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe
             660                 665                 670        
 Asn Asp Leu Ala Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met
         675                 680                 685            
 Gly Asp Glu Gln Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu
     690                 695                 700                
 Gly Glu Pro Leu Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu
 705                 710                 715                 720
 Gln Gly Ile
            



      <210> 315
      <211> 726
      <212> PRT
      <213> Homo sapiens


      <400> 315
 Met Glu Ser Gly Arg Gly Ser Ser Thr Pro Pro Gly Pro Ile Ala Ala
   1               5                  10                  15    
 Leu Gly Met Pro Asp Thr Gly Pro Gly Ser Ser Ser Leu Gly Lys Leu
              20                  25                  30        
 Gln Ala Leu Pro Val Gly Pro Arg Ala His Cys Gly Asp Pro Val Ser
          35                  40                  45            
 Leu Ala Ala Ala Gly Asp Gly Ser Pro Asp Ile Gly Pro Thr Gly Glu
      50                  55                  60                
 Leu Ser Gly Ser Leu Lys Ile Pro Asn Arg Asp Ser Gly Ile Asp Ser
  65                  70                  75                  80
 Pro Ser Ser Ser Val Ala Gly Glu Asn Phe Pro Cys Glu Glu Gly Leu
                  85                  90                  95    
 Glu Ala Gly Pro Ser Pro Thr Val Leu Gly Ala His Ala Glu Met Ala
             100                 105                 110        
 Leu Asp Ser Gln Val Pro Lys Val Thr Pro Gln Glu Glu Ala Asp Ser
         115                 120                 125            
 Asp Val Gly Glu Glu Pro Asp Ser Glu Asn Thr Pro Gln Lys Ala Asp
     130                 135                 140                
 Lys Asp Ala Gly Leu Ala Gln His Ser Gly Pro Gln Lys Leu Leu His
 145                 150                 155                 160
 Ile Ala Gln Glu Leu Leu His Thr Glu Glu Thr Tyr Val Lys Arg Leu
                 165                 170                 175    
 His Leu Leu Asp Gln Val Phe Cys Thr Arg Leu Thr Asp Ala Gly Ile
             180                 185                 190        
 Pro Pro Glu Val Ile Met Gly Ile Phe Ser Asn Ile Ser Ser Ile His
         195                 200                 205            
 Arg Phe His Gly Gln Phe Leu Leu Pro Glu Leu Lys Thr Arg Ile Thr
     210                 215                 220                
 Glu Glu Trp Asp Thr Asn Pro Arg Leu Gly Asp Ile Leu Gln Lys Leu
 225                 230                 235                 240
 Ala Pro Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg
                 245                 250                 255    
 Ala Val Gly Leu Val Ser Thr Trp Thr Gln Arg Ser Pro Leu Phe Lys
             260                 265                 270        
 Asp Val Val His Ser Ile Gln Lys Gln Glu Val Cys Gly Asn Leu Thr
         275                 280                 285            
 Leu Gln His His Met Leu Glu Pro Val Gln Arg Val Pro Arg Tyr Glu
     290                 295                 300                
 Leu Leu Leu Lys Asp Tyr Leu Lys Arg Leu Pro Gln Asp Ala Pro Asp
 305                 310                 315                 320
 Arg Lys Asp Ala Glu Arg Ser Leu Glu Leu Ile Ser Thr Ala Ala Asn
                 325                 330                 335    
 His Ser Asn Ala Ala Ile Arg Lys Val Glu Lys Met His Lys Leu Leu
             340                 345                 350        
 Glu Val Tyr Glu Gln Leu Gly Gly Glu Glu Asp Ile Val Asn Pro Ala
         355                 360                 365            
 Asn Glu Leu Ile Lys Glu Gly Gln Ile Gln Lys Leu Ser Ala Lys Asn
     370                 375                 380                
 Gly Thr Pro Gln Asp Arg His Leu Phe Leu Phe Asn Ser Met Ile Leu
 385                 390                 395                 400
 Tyr Cys Val Pro Lys Leu Arg Leu Met Gly Gln Lys Phe Ser Val Arg
                 405                 410                 415    
 Glu Lys Met Asp Ile Ser Gly Leu Gln Val Gln Asp Ile Val Lys Pro
             420                 425                 430        
 Asn Thr Ala His Thr Phe Ile Ile Thr Gly Arg Lys Arg Ser Leu Glu
         435                 440                 445            
 Leu Gln Thr Arg Thr Glu Glu Glu Lys Lys Glu Trp Ile Gln Ile Ile
     450                 455                 460                
 Gln Ala Thr Ile Glu Lys His Lys Gln Asn Ser Glu Thr Phe Lys Ala
 465                 470                 475                 480
 Phe Gly Gly Ala Phe Ser Gln Asp Glu Asp Pro Ser Leu Ser Pro Asp
                 485                 490                 495    
 Met Pro Ile Thr Ser Thr Ser Pro Val Glu Pro Val Val Thr Thr Glu
             500                 505                 510        
 Gly Ser Ser Gly Ala Ala Gly Leu Glu Pro Arg Lys Leu Ser Ser Lys
         515                 520                 525            
 Thr Arg Arg Asp Lys Glu Lys Gln Ser Cys Lys Ser Cys Gly Glu Thr
     530                 535                 540                
 Phe Asn Ser Ile Thr Lys Arg Arg His His Cys Lys Leu Cys Gly Ala
 545                 550                 555                 560
 Val Ile Cys Gly Lys Cys Ser Glu Phe Lys Ala Glu Asn Ser Arg Gln
                 565                 570                 575    
 Ser Arg Val Cys Arg Asp Cys Phe Leu Thr Gln Pro Val Ala Pro Glu
             580                 585                 590        
 Ser Thr Glu Lys Thr Pro Thr Ala Asp Pro Gln Pro Ser Leu Leu Cys
         595                 600                 605            
 Gly Pro Leu Arg Leu Ser Glu Ser Gly Glu Thr Trp Ser Glu Val Trp
     610                 615                 620                
 Ala Ala Ile Pro Met Ser Asp Pro Gln Val Leu His Leu Gln Gly Gly
 625                 630                 635                 640
 Ser Gln Asp Gly Arg Leu Pro Arg Thr Ile Pro Leu Pro Ser Cys Lys
                 645                 650                 655    
 Leu Ser Val Pro Asp Pro Glu Glu Arg Leu Asp Ser Gly His Val Trp
             660                 665                 670        
 Lys Leu Gln Trp Ala Lys Gln Ser Trp Tyr Leu Ser Ala Ser Ser Ala
         675                 680                 685            
 Glu Leu Gln Gln Gln Trp Leu Glu Thr Leu Ser Thr Ala Ala His Gly
     690                 695                 700                
 Asp Thr Ala Gln Asp Ser Pro Gly Ala Leu Gln Leu Gln Val Pro Met
 705                 710                 715                 720
 Gly Ala Ala Ala Pro
                 725



      <210> 316
      <211> 559
      <212> PRT
      <213> Homo sapiens


      <400> 316
 Met Ala Glu Leu Asn Thr His Val Asn Val Lys Glu Lys Ile Tyr Ala
   1               5                  10                  15    
 Val Arg Ser Val Val Pro Asn Lys Ser Asn Asn Glu Ile Val Leu Val
              20                  25                  30        
 Leu Gln Gln Phe Asp Phe Asn Val Asp Lys Ala Val Gln Ala Phe Val
          35                  40                  45            
 Asp Gly Ser Ala Ile Gln Val Leu Lys Glu Trp Asn Met Thr Gly Lys
      50                  55                  60                
 Lys Lys Asn Asn Lys Arg Lys Arg Ser Lys Ser Lys Gln His Gln Gly
  65                  70                  75                  80
 Asn Lys Asp Ala Lys Asp Lys Val Glu Arg Pro Glu Ala Gly Pro Leu
                  85                  90                  95    
 Gln Pro Gln Pro Pro Gln Ile Gln Asn Gly Pro Met Asn Gly Cys Glu
             100                 105                 110        
 Lys Asp Ser Ser Ser Thr Asp Ser Ala Asn Glu Lys Pro Ala Leu Ile
         115                 120                 125            
 Pro Arg Glu Lys Lys Ile Ser Ile Leu Glu Glu Pro Ser Lys Ala Leu
     130                 135                 140                
 Arg Gly Val Thr Glu Gly Asn Arg Leu Leu Gln Gln Lys Leu Ser Leu
 145                 150                 155                 160
 Asp Gly Asn Pro Lys Pro Ile His Gly Thr Thr Glu Arg Ser Asp Gly
                 165                 170                 175    
 Leu Gln Trp Ser Ala Glu Gln Pro Cys Asn Pro Ser Lys Pro Lys Ala
             180                 185                 190        
 Lys Thr Ser Pro Val Lys Ser Asn Thr Pro Ala Ala His Leu Glu Ile
         195                 200                 205            
 Lys Pro Asp Glu Leu Ala Lys Lys Arg Gly Pro Asn Ile Glu Lys Ser
     210                 215                 220                
 Val Lys Asp Leu Gln Arg Cys Thr Val Ser Leu Thr Arg Tyr Arg Val
 225                 230                 235                 240
 Met Ile Lys Glu Glu Val Asp Ser Ser Val Lys Lys Ile Lys Ala Ala
                 245                 250                 255    
 Phe Ala Glu Leu His Asn Cys Ile Ile Asp Lys Glu Val Ser Leu Met
             260                 265                 270        
 Ala Glu Met Asp Lys Val Lys Glu Glu Ala Met Glu Ile Leu Thr Ala
         275                 280                 285            
 Arg Gln Lys Lys Ala Glu Glu Leu Lys Arg Leu Thr Asp Leu Ala Ser
     290                 295                 300                
 Gln Met Ala Glu Met Gln Leu Ala Glu Leu Arg Ala Glu Ile Lys His
 305                 310                 315                 320
 Phe Val Ser Glu Arg Lys Tyr Asp Glu Glu Leu Gly Lys Ala Ala Arg
                 325                 330                 335    
 Phe Ser Cys Asp Ile Glu Gln Leu Lys Ala Gln Ile Met Leu Cys Gly
             340                 345                 350        
 Glu Ile Thr His Pro Lys Asn Asn Tyr Ser Ser Arg Thr Pro Cys Ser
         355                 360                 365            
 Ser Leu Leu Pro Leu Leu Asn Ala His Ala Ala Thr Ser Gly Lys Gln
     370                 375                 380                
 Ser Asn Phe Ser Arg Lys Ser Ser Thr His Asn Lys Pro Ser Glu Gly
 385                 390                 395                 400
 Lys Ala Ala Asn Pro Lys Met Val Ser Ser Leu Pro Ser Thr Ala Asp
                 405                 410                 415    
 Pro Ser His Gln Thr Met Pro Ala Asn Lys Gln Asn Gly Ser Ser Asn
             420                 425                 430        
 Gln Arg Arg Arg Phe Asn Pro Gln Tyr His Asn Asn Arg Leu Asn Gly
         435                 440                 445            
 Pro Ala Lys Ser Gln Gly Ser Gly Asn Glu Ala Glu Pro Leu Gly Lys
     450                 455                 460                
 Gly Asn Ser Arg His Glu His Arg Arg Gln Pro His Asn Gly Phe Arg
 465                 470                 475                 480
 Pro Lys Asn Lys Gly Gly Ala Lys Asn Gln Glu Ala Ser Leu Gly Met
                 485                 490                 495    
 Lys Thr Pro Glu Ala Pro Ala His Ser Glu Lys Pro Arg Arg Arg Gln
             500                 505                 510        
 His Ala Ala Asp Thr Ser Glu Ala Arg Pro Phe Arg Gly Ser Val Gly
         515                 520                 525            
 Arg Val Ser Gln Cys Asn Leu Cys Pro Thr Arg Ile Glu Val Ser Thr
     530                 535                 540                
 Asp Ala Ala Val Leu Ser Val Pro Ala Val Thr Leu Val Ala
 545                 550                 555            



      <210> 317
      <211> 490
      <212> PRT
      <213> Homo sapiens


      <400> 317
 Met Ala Glu Leu Asn Thr His Val Asn Val Lys Glu Lys Ile Tyr Ala
   1               5                  10                  15    
 Val Arg Ser Val Val Pro Asn Lys Ser Asn Asn Glu Ile Val Leu Val
              20                  25                  30        
 Leu Gln Gln Phe Asp Phe Asn Val Asp Lys Ala Val Gln Ala Phe Val
          35                  40                  45            
 Asp Gly Ser Ala Ile Gln Val Leu Lys Glu Trp Asn Met Thr Gly Lys
      50                  55                  60                
 Lys Lys Asn Asn Lys Arg Lys Arg Ser Lys Ser Lys Gln His Gln Gly
  65                  70                  75                  80
 Asn Lys Asp Ala Lys Asp Lys Val Glu Arg Pro Glu Ala Gly Pro Leu
                  85                  90                  95    
 Gln Pro Gln Pro Pro Gln Ile Gln Asn Gly Pro Met Asn Gly Cys Glu
             100                 105                 110        
 Lys Asp Ser Ser Ser Thr Asp Ser Ala Asn Glu Lys Pro Ala Leu Ile
         115                 120                 125            
 Pro Arg Glu Lys Lys Ile Ser Ile Leu Glu Glu Pro Ser Lys Ala Leu
     130                 135                 140                
 Arg Gly Val Thr Gly Pro Asn Ile Glu Lys Ser Val Lys Asp Leu Gln
 145                 150                 155                 160
 Arg Cys Thr Val Ser Leu Thr Arg Tyr Arg Val Met Ile Lys Glu Glu
                 165                 170                 175    
 Val Asp Ser Ser Val Lys Lys Ile Lys Ala Ala Phe Ala Glu Leu His
             180                 185                 190        
 Asn Cys Ile Ile Asp Lys Glu Val Ser Leu Met Ala Glu Met Asp Lys
         195                 200                 205            
 Val Lys Glu Glu Ala Met Glu Ile Leu Thr Ala Arg Gln Lys Lys Ala
     210                 215                 220                
 Glu Glu Leu Lys Arg Leu Thr Asp Leu Ala Ser Gln Met Ala Glu Met
 225                 230                 235                 240
 Gln Leu Ala Glu Leu Arg Ala Glu Ile Lys His Phe Val Ser Glu Arg
                 245                 250                 255    
 Lys Tyr Asp Glu Glu Leu Gly Lys Ala Ala Arg Phe Ser Cys Asp Ile
             260                 265                 270        
 Glu Gln Leu Lys Ala Gln Ile Met Leu Cys Gly Glu Ile Thr His Pro
         275                 280                 285            
 Lys Asn Asn Tyr Ser Ser Arg Thr Pro Cys Ser Ser Leu Leu Pro Leu
     290                 295                 300                
 Leu Asn Ala His Ala Ala Thr Ser Gly Lys Gln Ser Asn Phe Ser Arg
 305                 310                 315                 320
 Lys Ser Ser Thr His Asn Lys Pro Ser Glu Gly Lys Ala Ala Asn Pro
                 325                 330                 335    
 Lys Met Val Ser Ser Leu Pro Ser Thr Ala Asp Pro Ser His Gln Thr
             340                 345                 350        
 Met Pro Ala Asn Lys Gln Asn Gly Ser Ser Asn Gln Arg Arg Arg Phe
         355                 360                 365            
 Asn Pro Gln Tyr His Asn Asn Arg Leu Asn Gly Pro Ala Lys Ser Gln
     370                 375                 380                
 Gly Ser Gly Asn Glu Ala Glu Pro Leu Gly Lys Gly Asn Ser Arg His
 385                 390                 395                 400
 Glu His Arg Arg Gln Pro His Asn Gly Phe Arg Pro Lys Asn Lys Gly
                 405                 410                 415    
 Gly Ala Lys Asn Gln Glu Ala Ser Leu Gly Met Lys Thr Pro Glu Ala
             420                 425                 430        
 Pro Ala His Ser Glu Lys Pro Arg Arg Arg Gln His Ala Ala Asp Thr
         435                 440                 445            
 Ser Glu Ala Arg Pro Phe Arg Gly Ser Val Gly Arg Val Ser Gln Cys
     450                 455                 460                
 Asn Leu Cys Pro Thr Arg Ile Glu Val Ser Thr Asp Ala Ala Val Leu
 465                 470                 475                 480
 Ser Val Pro Ala Val Thr Leu Val Ala
                 485                



      <210> 318
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 318
 Met Met Gly Gln Glu Lys Val Pro Ile Lys Gln Val Pro Gly Gly Val
   1               5                  10                  15    
 Lys Gln Leu Glu Pro Pro Lys Glu Gly Glu Arg Arg Thr Thr His Asn
              20                  25                  30        
 Ile Ile Glu Lys Arg Tyr Arg Ser Ser Ile Asn Asp Lys Ile Ile Glu
          35                  40                  45            
 Leu Lys Asp Leu Val Met Gly Thr Asp Ala Lys Met His Lys Ser Gly
      50                  55                  60                
 Val Leu Arg Lys Ala Ile Asp Tyr Thr Arg Cys Leu Lys Gly Leu His
  65                  70                  75                  80
 Gly Phe Pro Ala Leu Pro Gly Ser Gly Gln Leu Gly Lys Gly His Ser
                  85                  90                  95    
 Ser Ser Ser Ala Ala Leu Gln Ser Leu Gly Ala Gly Arg Ala Gly His
             100                 105                 110        
 Val Glu Pro
         115



      <210> 319
      <211> 912
      <212> PRT
      <213> Homo sapiens


      <400> 319
 Met Val Phe Leu Gln Asn His Val Arg Phe Phe Leu Glu Ser Leu Pro
   1               5                  10                  15    
 Ala Phe Leu Arg Val Leu Ile Gln Ala Gly Ala Leu Cys Trp Ser Leu
              20                  25                  30        
 Pro Glu Leu Ser Gln Gly Glu Val Gly Lys Gly Ala Cys Pro Ala Glu
          35                  40                  45            
 Val Gly Lys His Arg Asp His Leu Pro Ser Ser Asp Pro Val Leu Met
      50                  55                  60                
 Gln Ala Glu Ala Ser Val Val Met Cys Trp Val Ser Ser Glu Asp Arg
  65                  70                  75                  80
 Ser Ala Leu Trp Ala Leu Val Thr Phe Tyr Gly Gly Asp Cys Gln Leu
                  85                  90                  95    
 Thr Leu Asn Lys Lys Cys Thr His Leu Ile Val Pro Glu Pro Lys Gly
             100                 105                 110        
 Gly Lys Tyr Glu Cys Ala Leu Lys Arg Ala Ser Ile Lys Ile Val Thr
         115                 120                 125            
 Pro Asp Trp Val Leu Asp Cys Val Ser Glu Lys Thr Lys Lys Asp Glu
     130                 135                 140                
 Ala Phe Tyr His Pro Arg Leu Ile Ile Tyr Glu Glu Glu Glu Glu Glu
 145                 150                 155                 160
 Glu Glu Glu Glu Glu Glu Val Glu Asn Glu Glu Gln Asp Ser Gln Asn
                 165                 170                 175    
 Glu Gly Ser Thr Asp Glu Lys Ser Ser Pro Ala Ser Ser Gln Glu Gly
             180                 185                 190        
 Ser Pro Ser Gly Asp Gln Gln Phe Ser Pro Lys Ser Asn Thr Glu Lys
         195                 200                 205            
 Ser Lys Gly Glu Leu Met Phe Asp Asp Ser Ser Asp Ser Ser Pro Glu
     210                 215                 220                
 Lys Gln Glu Arg Asn Leu Asn Trp Thr Pro Ala Glu Val Pro Gln Leu
 225                 230                 235                 240
 Ala Ala Ala Lys Arg Arg Leu Pro Gln Gly Lys Glu Pro Gly Leu Ile
                 245                 250                 255    
 Asn Leu Cys Ala Asn Val Pro Pro Val Pro Gly Asn Ile Leu Pro Pro
             260                 265                 270        
 Glu Val Arg Gly Asn Leu Met Ala Ala Gly Gln Asn Leu Gln Ser Ser
         275                 280                 285            
 Glu Arg Ser Glu Met Ile Ala Thr Trp Ser Pro Ala Val Arg Thr Leu
     290                 295                 300                
 Arg Asn Ile Thr Asn Asn Ala Asp Ile Gln Gln Met Asn Arg Pro Ser
 305                 310                 315                 320
 Asn Val Ala His Ile Leu Gln Thr Leu Ser Ala Pro Thr Lys Asn Leu
                 325                 330                 335    
 Glu Gln Gln Val Asn His Ser Gln Gln Gly His Thr Asn Ala Asn Ala
             340                 345                 350        
 Val Leu Phe Ser Gln Val Lys Val Thr Pro Glu Thr His Met Leu Gln
         355                 360                 365            
 Gln Gln Gln Gln Ala Gln Gln Gln Gln Gln Gln His Pro Val Leu His
     370                 375                 380                
 Leu Gln Pro Gln Gln Ile Met Gln Leu Gln Gln Gln Gln Gln Gln Gln
 385                 390                 395                 400
 Ile Ser Gln Gln Pro Tyr Pro Gln Gln Pro Pro His Pro Phe Ser Gln
                 405                 410                 415    
 Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Ser Pro Gln Gln His Gln
             420                 425                 430        
 Leu Phe Gly His Asp Pro Ala Val Glu Ile Pro Glu Glu Gly Phe Leu
         435                 440                 445            
 Leu Gly Cys Val Phe Ala Ile Ala Asp Tyr Pro Glu Gln Met Ser Asp
     450                 455                 460                
 Lys Gln Leu Leu Ala Thr Trp Lys Arg Ile Ile Gln Ala His Gly Gly
 465                 470                 475                 480
 Thr Val Asp Pro Thr Phe Thr Ser Arg Cys Thr His Leu Leu Cys Glu
                 485                 490                 495    
 Ser Gln Val Ser Ser Ala Tyr Ala Gln Ala Ile Arg Glu Arg Lys Arg
             500                 505                 510        
 Cys Val Thr Ala His Trp Leu Asn Thr Val Leu Lys Lys Lys Lys Met
         515                 520                 525            
 Val Pro Pro His Arg Ala Leu His Phe Pro Val Ala Phe Pro Pro Gly
     530                 535                 540                
 Gly Lys Pro Cys Ser Gln His Ile Ile Ser Val Thr Gly Phe Val Asp
 545                 550                 555                 560
 Ser Asp Arg Asp Asp Leu Lys Leu Met Ala Tyr Leu Ala Gly Ala Lys
                 565                 570                 575    
 Tyr Thr Gly Tyr Leu Cys Arg Ser Asn Thr Val Leu Ile Cys Lys Glu
             580                 585                 590        
 Pro Thr Gly Leu Lys Tyr Glu Lys Ala Lys Glu Trp Arg Ile Pro Cys
         595                 600                 605            
 Val Asn Ala Gln Trp Leu Gly Asp Ile Leu Leu Gly Asn Phe Glu Ala
     610                 615                 620                
 Leu Arg Gln Ile Gln Tyr Ser Arg Tyr Thr Ala Phe Ser Leu Gln Asp
 625                 630                 635                 640
 Pro Phe Ala Pro Thr Gln His Leu Val Leu Asn Leu Leu Asp Ala Trp
                 645                 650                 655    
 Arg Val Pro Leu Lys Val Ser Ala Glu Leu Leu Met Ser Ile Arg Leu
             660                 665                 670        
 Pro Pro Lys Leu Lys Gln Asn Glu Val Ala Asn Val Gln Pro Ser Ser
         675                 680                 685            
 Gln Arg Ala Arg Ile Glu Asp Val Pro Pro Pro Thr Lys Lys Leu Thr
     690                 695                 700                
 Pro Glu Leu Thr Pro Phe Val Leu Phe Thr Gly Phe Glu Pro Val Gln
 705                 710                 715                 720
 Val Gln Gln Tyr Ile Lys Lys Leu Tyr Ile Leu Gly Gly Glu Val Ala
                 725                 730                 735    
 Glu Ser Ala Gln Lys Cys Thr His Leu Ile Ala Ser Lys Val Thr Arg
             740                 745                 750        
 Thr Val Lys Phe Leu Thr Ala Ile Ser Val Val Lys His Ile Val Thr
         755                 760                 765            
 Pro Glu Trp Leu Glu Glu Cys Phe Arg Cys Gln Lys Phe Ile Asp Glu
     770                 775                 780                
 Gln Asn Tyr Ile Leu Arg Asp Ala Glu Ala Glu Val Leu Phe Ser Phe
 785                 790                 795                 800
 Ser Leu Glu Glu Ser Leu Lys Arg Ala His Val Ser Pro Leu Phe Lys
                 805                 810                 815    
 Ala Lys Tyr Phe Tyr Ile Thr Pro Gly Ile Cys Pro Ser Leu Ser Thr
             820                 825                 830        
 Met Lys Ala Ile Val Glu Cys Ala Gly Gly Lys Val Leu Ser Lys Gln
         835                 840                 845            
 Pro Ser Phe Arg Lys Leu Met Glu His Lys Gln Asn Ser Ser Leu Ser
     850                 855                 860                
 Glu Ile Ile Leu Ile Ser Cys Glu Asn Asp Leu His Leu Cys Arg Glu
 865                 870                 875                 880
 Tyr Phe Ala Arg Gly Ile Asp Val His Asn Ala Glu Phe Val Leu Thr
                 885                 890                 895    
 Gly Val Leu Thr Gln Thr Leu Asp Tyr Glu Ser Tyr Lys Phe Asn
             900                 905                 910    



      <210> 320
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 320
 Met Ala Gly Ala Pro Pro Pro Ala Ser Leu Pro Pro Cys Ser Leu Ile
   1               5                  10                  15    
 Ser Asp Cys Cys Ala Ser Asn Gln Arg Asp Ser Val Gly Val Gly Pro
              20                  25                  30        
 Ser Glu Pro Gly Val Gly Tyr Ser Leu Val Val Arg Arg Phe Leu Ser
          35                  40                  45            
 Arg Ser Glu Lys Arg Asn Ile Arg Val Gly Val Thr Arg Phe Ser Arg
      50                  55                  60                
 Cys Val Arg His Pro Phe Leu
  65                  70    



      <210> 321
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 321
 Met Ser Gly Arg Ser Gly Tyr Arg Leu Ser Leu Leu Leu Leu Ala Ala
   1               5                  10                  15    
 Leu Gly Ser Gly Arg Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg
              20                  25                  30        
 Val Lys Glu Asn Phe Asp Lys Ala Arg Phe Ser Gly Thr Trp Tyr Ala
          35                  40                  45            
 Met Ala Lys Lys Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Val
      50                  55                  60                
 Ala Glu Phe Ser Val Asp Glu Thr Gly Gln Met Ser Ala Thr Ala Lys
  65                  70                  75                  80
 Gly Arg Val Arg Leu Leu Asn Asn Trp Asp Val Cys Ala Asp Met Val
                  85                  90                  95    
 Gly Thr Phe Thr Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr
             100                 105                 110        
 Trp Gly Val Ala Ser Phe Leu Gln Lys Gly Asn Asp Asp His Trp Ile
         115                 120                 125            
 Val Asp Thr Asp Tyr Asp Thr Tyr Ala Val Gln Tyr Ser Cys Arg Leu
     130                 135                 140                
 Leu Asn Leu Asp Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser
 145                 150                 155                 160
 Arg Asp Pro Asn Gly Leu Pro Pro Glu Ala Gln Lys Ile Val Arg Gln
                 165                 170                 175    
 Arg Gln Glu Glu Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile Val His
             180                 185                 190        
 Asn Gly Tyr Cys Asp Gly Arg Ser Glu Arg Asn Leu Leu
         195                 200                 205



      <210> 322
      <211> 838
      <212> PRT
      <213> Homo sapiens


      <400> 322
 Met Ala Ala Pro Gly Ala Pro Ala Glu Tyr Gly Tyr Ile Arg Thr Val
   1               5                  10                  15    
 Leu Gly Gln Gln Ile Leu Gly Gln Leu Asp Ser Ser Ser Leu Ala Leu
              20                  25                  30        
 Pro Ser Glu Ala Lys Leu Lys Leu Ala Gly Ser Ser Gly Arg Gly Gly
          35                  40                  45            
 Gln Thr Val Lys Ser Leu Arg Ile Gln Glu Gln Val Gln Gln Thr Leu
      50                  55                  60                
 Ala Arg Lys Gly Arg Ser Ser Val Gly Asn Gly Asn Leu His Arg Thr
  65                  70                  75                  80
 Ser Ser Val Pro Glu Tyr Val Tyr Asn Leu His Leu Val Glu Asn Asp
                  85                  90                  95    
 Phe Val Gly Gly Arg Ser Pro Val Pro Lys Thr Tyr Asp Met Leu Lys
             100                 105                 110        
 Ala Gly Thr Ile Ala Thr Tyr Glu Gly Arg Trp Gly Arg Gly Thr Ala
         115                 120                 125            
 Gln Tyr Ser Ser Gln Lys Ser Val Glu Glu Arg Ser Leu Arg His Pro
     130                 135                 140                
 Leu Arg Arg Leu Glu Ile Ser Pro Asp Ser Ser Pro Glu Arg Ala His
 145                 150                 155                 160
 Tyr Thr His Ser Asp Tyr Gln Tyr Ser Gln Arg Ser Gln Ala Gly His
                 165                 170                 175    
 Thr Leu His His Gln Glu Ser Arg Arg Ala Ala Leu Leu Val Pro Pro
             180                 185                 190        
 Arg Tyr Ala Arg Ser Glu Ile Val Gly Val Ser Arg Ala Gly Thr Thr
         195                 200                 205            
 Ser Arg Gln Arg His Phe Asp Thr Tyr His Arg Gln Tyr Gln His Gly
     210                 215                 220                
 Ser Val Ser Asp Thr Val Phe Asp Ser Ile Pro Ala Asn Pro Ala Leu
 225                 230                 235                 240
 Leu Thr Tyr Pro Arg Pro Gly Thr Ser Arg Ser Met Gly Asn Leu Leu
                 245                 250                 255    
 Glu Lys Glu Asn Tyr Leu Thr Ala Gly Leu Thr Val Gly Gln Val Arg
             260                 265                 270        
 Pro Leu Val Pro Leu Gln Pro Val Thr Gln Asn Arg Ala Ser Arg Ser
         275                 280                 285            
 Ser Trp His Gln Ser Ser Phe His Ser Thr Arg Thr Leu Arg Glu Ala
     290                 295                 300                
 Gly Pro Ser Val Ala Val Asp Ser Ser Gly Arg Arg Ala His Leu Thr
 305                 310                 315                 320
 Val Gly Gln Ala Ala Ala Gly Gly Ser Gly Asn Leu Leu Thr Glu Arg
                 325                 330                 335    
 Ser Thr Phe Thr Asp Ser Gln Leu Gly Asn Ala Asp Met Glu Met Thr
             340                 345                 350        
 Leu Glu Arg Ala Val Ser Met Leu Glu Ala Asp His Met Pro Pro Ser
         355                 360                 365            
 Arg Ile Ser Ala Ala Ala Thr Phe Ile Gln His Glu Cys Phe Gln Lys
     370                 375                 380                
 Ser Glu Ala Arg Lys Arg Val Asn Gln Leu Arg Gly Ile Leu Lys Leu
 385                 390                 395                 400
 Leu Gln Leu Leu Lys Val Gln Asn Glu Asp Val Gln Arg Ala Val Cys
                 405                 410                 415    
 Gly Ala Leu Arg Asn Leu Val Phe Glu Asp Asn Asp Asn Lys Leu Glu
             420                 425                 430        
 Val Ala Glu Leu Asn Gly Val Pro Arg Leu Leu Gln Val Leu Lys Gln
         435                 440                 445            
 Thr Arg Asp Leu Glu Thr Lys Lys Gln Ile Thr Gly Leu Leu Trp Asn
     450                 455                 460                
 Leu Ser Ser Asn Asp Lys Leu Lys Asn Leu Met Ile Thr Glu Ala Leu
 465                 470                 475                 480
 Leu Thr Leu Thr Glu Asn Ile Ile Ile Pro Phe Ser Gly Trp Pro Glu
                 485                 490                 495    
 Gly Asp Tyr Pro Lys Ala Asn Gly Leu Leu Asp Phe Asp Ile Phe Tyr
             500                 505                 510        
 Asn Val Thr Gly Cys Leu Arg Asn Met Ser Ser Ala Gly Ala Asp Gly
         515                 520                 525            
 Arg Lys Ala Met Arg Arg Cys Asp Gly Leu Ile Asp Ser Leu Val His
     530                 535                 540                
 Tyr Val Arg Gly Thr Ile Ala Asp Tyr Gln Pro Asp Asp Lys Ala Thr
 545                 550                 555                 560
 Glu Asn Cys Val Cys Ile Leu His Asn Leu Ser Tyr Gln Leu Glu Ala
                 565                 570                 575    
 Glu Leu Pro Glu Lys Tyr Ser Gln Asn Ile Tyr Ile Gln Asn Arg Asn
             580                 585                 590        
 Ile Gln Thr Asp Asn Asn Lys Ser Ile Gly Cys Phe Gly Ser Arg Ser
         595                 600                 605            
 Arg Lys Val Lys Glu Gln Tyr Gln Asp Val Pro Met Pro Glu Glu Lys
     610                 615                 620                
 Ser Asn Pro Lys Gly Val Glu Trp Leu Trp His Ser Ile Val Ile Arg
 625                 630                 635                 640
 Met Tyr Leu Ser Leu Ile Ala Lys Ser Val Arg Asn Tyr Thr Gln Glu
                 645                 650                 655    
 Ala Ser Leu Gly Ala Leu Gln Asn Leu Thr Ala Gly Ser Gly Pro Met
             660                 665                 670        
 Pro Thr Ser Val Ala Gln Thr Val Val Gln Lys Glu Ser Gly Leu Gln
         675                 680                 685            
 His Thr Arg Lys Met Leu His Val Gly Asp Pro Ser Val Lys Lys Thr
     690                 695                 700                
 Ala Ile Ser Leu Leu Arg Asn Leu Ser Arg Asn Leu Ser Leu Gln Asn
 705                 710                 715                 720
 Glu Ile Ala Lys Glu Thr Leu Pro Asp Leu Val Ser Ile Ile Pro Asp
                 725                 730                 735    
 Thr Val Pro Ser Thr Asp Leu Leu Ile Glu Thr Thr Ala Ser Ala Cys
             740                 745                 750        
 Tyr Thr Leu Asn Asn Ile Ile Gln Asn Ser Tyr Gln Asn Ala Arg Asp
         755                 760                 765            
 Leu Leu Asn Thr Gly Gly Ile Gln Lys Ile Met Ala Ile Ser Ala Gly
     770                 775                 780                
 Asp Ala Tyr Ala Ser Asn Lys Ala Ser Lys Ala Ala Ser Val Leu Leu
 785                 790                 795                 800
 Tyr Ser Leu Trp Ala His Thr Glu Leu His His Ala Tyr Lys Lys Ala
                 805                 810                 815    
 Gln Phe Lys Lys Thr Asp Phe Val Asn Ser Arg Thr Ala Lys Ala Tyr
             820                 825                 830        
 His Ser Leu Lys Asp
         835        



      <210> 323
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 323
 Met Ala Ala Thr His Thr Pro Pro Leu Ala Ser Pro Gly Met Ala Arg
   1               5                  10                  15    
 Ile Cys Leu Tyr Gly Asp Leu Gln Arg Phe Gly Arg Arg Ile Asp Leu
              20                  25                  30        
 Arg Val Lys Thr Gly Ala Glu Ala Ile Arg Ala Leu Ala Thr Gln Leu
          35                  40                  45            
 Pro Ala Phe Arg Gln Lys Leu Ser Asp Gly Trp Tyr Gln Val Arg Ile
      50                  55                  60                
 Ala Gly Arg Asp Val Ser Thr Ser Gly Leu Thr Ala Gln Leu His Glu
  65                  70                  75                  80
 Thr Leu Pro Asp Gly Ala Val Ile His Ile Val Pro Arg Val Ala Gly
                  85                  90                  95    
 Ala Lys Ser Gly Gly Val Phe Gln Ile Val Leu Gly Ala Ala Ala Ile
             100                 105                 110        
 Ala Gly Ser Phe Phe Thr Ala Gly Ala Thr Leu Ala Ala Trp Gly Ala
         115                 120                 125            
 Ala Ile Gly Ala Gly Gly Met Thr Gly Ile Leu Phe Ser Leu Gly Ala
     130                 135                 140                
 Ser Met Val Leu Gly Gly Val Ala Gln Met Leu Ala Pro Lys Ala Arg
 145                 150                 155                 160
 Thr Pro Arg Ile Gln Thr Thr Asp Asn Gly Lys Gln Asn Thr Tyr Phe
                 165                 170                 175    
 Ser Ser Leu Asp Asn Met Val Ala Gln Gly Asn Val Leu Pro Val Leu
             180                 185                 190        
 Tyr Gly Glu Met Arg Val Gly Ser Arg Val Val Ser Gln Glu Ile Ser
         195                 200                 205            
 Thr Ala Asp Glu Gly Asp Gly Gly Gln Val Val Val Ile Gly Arg
     210                 215                 220            



      <210> 324
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 324
 Met Asp Asp Leu Thr Lys Leu Val Gln Glu Gln Lys Pro Lys Gly Ser
   1               5                  10                  15    
 Gln Arg Ser Arg Lys Arg Gly His Thr Ala Ser Glu Ser Asp Glu Gln
              20                  25                  30        
 Gln Trp Pro Glu Glu Lys Arg Leu Lys Glu Asp Ile Leu Glu Asn Glu
          35                  40                  45            
 Asp Glu Gln Asn Ser Pro Pro Lys Lys Gly Lys Arg Gly Arg Pro Pro
      50                  55                  60                
 Lys Pro Leu Gly Gly Gly Thr Pro Lys Glu Glu Pro Thr Met Lys Thr
  65                  70                  75                  80
 Ser Lys Lys Gly Ser Lys Lys Lys Ser Gly Pro Pro Ala Pro Glu Glu
                  85                  90                  95    
 Glu Glu Glu Glu Glu Arg Gln Ser Gly Asn Thr Glu Gln Lys Ser Lys
             100                 105                 110        
 Ser Lys Gln His Arg Val Ser Arg Arg Ala Gln Gln Arg Ala Glu Ser
         115                 120                 125            
 Pro Glu Ser Ser Ala Ile Glu Ser Thr Gln Ser Thr Pro Gln Lys Gly
     130                 135                 140                
 Arg Gly Arg Pro Ser Lys Thr Pro Ser Pro Ser Gln Pro Lys Lys Asn
 145                 150                 155                 160
 Val Arg Val Gly Arg Ser Lys Gln Ala Ala Thr Lys Glu Asn Asp Ser
                 165                 170                 175    
 Ser Glu Glu Val Asp Val Phe Gln Gly Ser Ser Pro Val Asp Asp Ile
             180                 185                 190        
 Pro Gln Glu Glu Thr Glu Glu Glu Glu Val Ser Thr Val Asn Val Arg
         195                 200                 205            
 Arg Arg Ser Ala Lys Arg Glu Arg Arg
     210                 215        



      <210> 325
      <211> 373
      <212> PRT
      <213> Homo sapiens


      <400> 325
 Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro
   1               5                  10                  15    
 Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro
              20                  25                  30        
 Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro
          35                  40                  45            
 Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala
      50                  55                  60                
 Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Thr Ala Ala Gly Ser Glu
  65                  70                  75                  80
 Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys
                  85                  90                  95    
 Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
             100                 105                 110        
 Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
         115                 120                 125            
 Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp
     130                 135                 140                
 Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
 145                 150                 155                 160
 Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg
                 165                 170                 175    
 Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Tyr
             180                 185                 190        
 Ala Gly Glu Glu Glu Glu Glu Gly Ser Gly Ser Ser Glu Gly Phe Asp
         195                 200                 205            
 Pro Pro Ala Thr Asp Arg Gln Phe Ser Gly Ala Arg Asn Gln Leu Arg
     210                 215                 220                
 Arg Pro Gln Tyr Arg Pro Gln Tyr Arg Gln Arg Arg Phe Pro Pro Tyr
 225                 230                 235                 240
 His Val Gly Gln Thr Phe Asp Arg Arg Ser Arg Val Leu Pro His Pro
                 245                 250                 255    
 Asn Arg Ile Gln Ala Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro
             260                 265                 270        
 Glu Gly Ala Gln Leu Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg
         275                 280                 285            
 Pro Arg Tyr Arg Ser Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala
     290                 295                 300                
 Val Gly Glu Ala Glu Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro
 305                 310                 315                 320
 Asn Gln Pro Ser Val Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg
                 325                 330                 335    
 Arg Arg Pro Arg Pro Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala
             340                 345                 350        
 Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln
         355                 360                 365            
 Ser Ser Ala Glu
     370        



      <210> 326
      <211> 303
      <212> PRT
      <213> Homo sapiens


      <400> 326
 Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro
   1               5                  10                  15    
 Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro
              20                  25                  30        
 Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro
          35                  40                  45            
 Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala
      50                  55                  60                
 Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Thr Ala Ala Gly Ser Glu
  65                  70                  75                  80
 Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys
                  85                  90                  95    
 Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
             100                 105                 110        
 Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
         115                 120                 125            
 Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp
     130                 135                 140                
 Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
 145                 150                 155                 160
 Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg
                 165                 170                 175    
 Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Ala
             180                 185                 190        
 Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro Glu Gly Ala Gln Leu
         195                 200                 205            
 Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg Pro Arg Tyr Arg Ser
     210                 215                 220                
 Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala Val Gly Glu Ala Glu
 225                 230                 235                 240
 Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro Asn Gln Pro Ser Val
                 245                 250                 255    
 Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg Arg Arg Pro Arg Pro
             260                 265                 270        
 Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala Lys Ala Gly Glu Ala
         275                 280                 285            
 Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln Ser Ser Ala Glu
     290                 295                 300            



      <210> 327
      <211> 104
      <212> PRT
      <213> Homo sapiens


      <400> 327
 Met Ser Glu Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asp His
   1               5                  10                  15    
 Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe Lys
              20                  25                  30        
 Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys Glu
          35                  40                  45            
 Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly Gln
      50                  55                  60                
 Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp Glu
  65                  70                  75                  80
 Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Pro Glu Ser
                  85                  90                  95    
 Ser Leu Ala Gly His Ser Phe
             100            



      <210> 328
      <211> 417
      <212> PRT
      <213> Homo sapiens


      <400> 328
 Met Ala Glu Glu Gln Gly Arg Glu Arg Asp Ser Val Pro Lys Pro Ser
   1               5                  10                  15    
 Val Leu Phe Leu His Pro Asp Leu Gly Val Gly Gly Ala Glu Arg Leu
              20                  25                  30        
 Val Leu Asp Ala Ala Leu Ala Leu Gln Ala Arg Gly Cys Ser Val Lys
          35                  40                  45            
 Ile Trp Thr Ala His Tyr Asp Pro Gly His Cys Phe Ala Glu Ser Arg
      50                  55                  60                
 Glu Leu Pro Val Arg Cys Ala Gly Asp Trp Leu Pro Arg Gly Leu Gly
  65                  70                  75                  80
 Trp Gly Gly Arg Gly Ala Ala Val Cys Ala Tyr Val Arg Met Val Phe
                  85                  90                  95    
 Leu Ala Leu Tyr Val Leu Phe Leu Ala Asp Glu Glu Phe Asp Val Val
             100                 105                 110        
 Val Cys Asp Gln Val Ser Ala Cys Ile Pro Val Phe Arg Leu Ala Arg
         115                 120                 125            
 Arg Arg Lys Lys Ile Leu Phe Tyr Cys His Phe Pro Asp Leu Leu Leu
     130                 135                 140                
 Thr Lys Arg Asp Ser Phe Leu Lys Arg Leu Tyr Arg Ala Pro Ile Asp
 145                 150                 155                 160
 Trp Ile Glu Glu Tyr Thr Thr Gly Met Ala Asp Cys Ile Leu Val Asn
                 165                 170                 175    
 Ser Gln Phe Thr Ala Ala Val Phe Lys Glu Thr Phe Lys Ser Leu Ser
             180                 185                 190        
 His Ile Asp Pro Asp Val Leu Tyr Pro Ser Leu Asn Val Thr Ser Phe
         195                 200                 205            
 Asp Ser Val Val Pro Glu Lys Leu Asp Asp Leu Val Pro Lys Gly Lys
     210                 215                 220                
 Lys Phe Leu Leu Leu Ser Ile Asn Arg Tyr Glu Arg Lys Lys Asn Leu
 225                 230                 235                 240
 Thr Leu Ala Leu Glu Ala Leu Val Gln Leu Arg Gly Arg Leu Thr Ser
                 245                 250                 255    
 Gln Asp Trp Glu Arg Val His Leu Ile Val Ala Gly Gly Tyr Asp Glu
             260                 265                 270        
 Arg Val Leu Glu Asn Val Glu His Tyr Gln Glu Leu Lys Lys Met Val
         275                 280                 285            
 Gln Gln Ser Asp Leu Gly Gln Tyr Val Thr Phe Leu Arg Ser Phe Ser
     290                 295                 300                
 Asp Lys Gln Lys Ile Ser Leu Leu His Ser Cys Thr Cys Val Leu Tyr
 305                 310                 315                 320
 Thr Pro Ser Asn Glu His Phe Gly Ile Val Pro Leu Glu Ala Met Tyr
                 325                 330                 335    
 Met Gln Cys Pro Val Ile Ala Val Asn Ser Gly Gly Pro Leu Glu Ser
             340                 345                 350        
 Ile Asp His Ser Val Thr Gly Phe Leu Cys Glu Pro Asp Pro Val His
         355                 360                 365            
 Phe Ser Glu Ala Ile Glu Lys Phe Ile Arg Glu Pro Ser Leu Lys Ala
     370                 375                 380                
 Thr Met Gly Leu Ala Gly Arg Ala Arg Val Lys Glu Lys Phe Ser Pro
 385                 390                 395                 400
 Glu Ala Phe Thr Glu Gln Leu Tyr Arg Tyr Val Thr Lys Leu Leu Val
                 405                 410                 415    





      <210> 329
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 329
 Met Glu Glu Glu Glu Ile Arg Thr Trp Ser Phe Pro Gly Ala Asn Pro
   1               5                  10                  15    
 Arg Gly Gly His Gln Cys Gly Ser Ala Leu Ser Cys Asp Glu Gly Val
              20                  25                  30        
 Pro Ala Ala Gln Gly Ala Ser Ser Glu Lys Pro His Glu Cys Thr Lys
          35                  40                  45            
 Cys Gly Lys Ala Leu Cys Cys Arg Ser Asp Leu Arg Val His His Gly
      50                  55                  60                
 Val His Ala Gly Glu Lys Ser Ser Ala Cys Ser Glu Arg Gly Ser Gly
  65                  70                  75                  80
 Phe Arg Glu Lys Leu Cys Pro Asp Lys Gln Gly Thr His Thr Lys Glu
                  85                  90                  95    
 Lys Pro Ala Arg Asp Ser Arg Ser Gly Lys Thr Ile Phe Arg Lys Thr
             100                 105                 110        
 Arg Leu Cys Val Pro Gly Thr Val His Ala Gly Ala Lys Pro Tyr Lys
         115                 120                 125            
 Cys Trp Glu Cys Glu Lys Thr Ser His Lys Ser Arg Leu Ile Glu His
     130                 135                 140                
 Leu Arg Ser His Thr Gly Glu Lys Pro Cys Gly Cys Arg Glu Cys Gly
 145                 150                 155                 160
 Lys Ala Phe Phe Gln Lys Ser His Leu Ile Leu Arg Gln Arg Thr His
                 165                 170                 175    
 Thr Gly Glu Lys Pro Cys Asp Cys Ala Glu Cys Gly Lys Ala Ala Pro
             180                 185                 190        
 Arg Thr Pro Ala Ser
         195        



      <210> 330
      <211> 342
      <212> PRT
      <213> Homo sapiens


      <400> 330
 Met Ser Met Tyr Thr Thr Ala Gln Leu Leu Ala Ala Asn Glu Gln Lys
   1               5                  10                  15    
 Phe Lys Phe Asp Pro Leu Phe Leu Arg Leu Phe Phe Arg Glu Ser Tyr
              20                  25                  30        
 Pro Phe Thr Thr Glu Lys Val Tyr Leu Ser Gln Ile Pro Gly Leu Val
          35                  40                  45            
 Asn Met Ala Leu Tyr Val Ser Pro Ile Val Ser Gly Glu Val Ile Arg
      50                  55                  60                
 Ser Arg Gly Gly Ser Thr Ser Glu Phe Thr Pro Gly Tyr Val Lys Pro
  65                  70                  75                  80
 Lys His Glu Val Asn Pro Gln Met Thr Leu Arg Arg Leu Pro Asp Glu
                  85                  90                  95    
 Asp Pro Gln Asn Leu Ala Asp Pro Ala Tyr Arg Arg Arg Arg Ile Ile
             100                 105                 110        
 Met Gln Asn Met Arg Asp Glu Glu Leu Ala Ile Ala Gln Val Glu Glu
         115                 120                 125            
 Met Gln Ala Val Ser Ala Val Leu Lys Gly Lys Tyr Thr Met Thr Gly
     130                 135                 140                
 Glu Ala Phe Asp Pro Val Glu Val Asp Met Gly Arg Ser Glu Glu Asn
 145                 150                 155                 160
 Asn Ile Thr Gln Ser Gly Gly Thr Glu Trp Ser Lys Arg Asp Lys Ser
                 165                 170                 175    
 Thr Tyr Asp Pro Thr Asp Asp Ile Glu Ala Tyr Ala Leu Asn Ala Ser
             180                 185                 190        
 Gly Val Val Asn Ile Ile Val Phe Asp Pro Lys Gly Trp Ala Leu Phe
         195                 200                 205            
 Arg Ser Phe Lys Ala Val Lys Glu Lys Leu Asp Thr Arg Arg Gly Ser
     210                 215                 220                
 Asn Ser Glu Leu Glu Thr Ala Val Lys Asp Leu Gly Lys Ala Val Ser
 225                 230                 235                 240
 Tyr Lys Gly Met Tyr Gly Asp Val Ala Ile Val Val Tyr Ser Gly Gln
                 245                 250                 255    
 Tyr Val Glu Asn Gly Val Lys Lys Asn Phe Leu Pro Asp Asn Thr Met
             260                 265                 270        
 Val Leu Gly Asn Thr Gln Ala Arg Gly Leu Arg Thr Tyr Gly Cys Ile
         275                 280                 285            
 Gln Asp Ala Asp Ala Gln Arg Glu Gly Ile Asn Ala Ser Ala Arg Tyr
     290                 295                 300                
 Pro Lys Asn Trp Val Thr Thr Gly Asp Pro Ala Arg Glu Phe Thr Met
 305                 310                 315                 320
 Ile Gln Ser Ala Pro Leu Met Leu Leu Ala Asp Pro Asp Glu Phe Val
                 325                 330                 335    
 Ser Val Gln Leu Ala
             340    



      <210> 331
      <211> 77
      <212> PRT
      <213> Homo sapiens


      <400> 331
 Met Lys Met Arg Lys Asn Gln Cys Lys Lys Ala Glu Asn Ser Lys Asn
   1               5                  10                  15    
 Gln Asn Gly Ser Ser Pro Ala Lys Asp Tyr Asn Ser Ser Pro Ala Arg
              20                  25                  30        
 Glu Gln Asn Trp Met Glu Asn Trp Leu Asp Lys Leu Thr Glu Val Gly
          35                  40                  45            
 Phe Ile Arg Trp Ile Ile Thr Asn Ser Phe Lys Leu Lys Glu His Val
      50                  55                  60                
 Leu Thr Gln Cys Lys Glu Leu Arg Ser Leu Lys Lys Ser
  65                  70                  75        



      <210> 332
      <211> 188
      <212> PRT
      <213> Homo sapiens


      <400> 332
 Met Glu Arg Gln Glu Glu Ser Leu Ser Ala Arg Pro Ala Leu Glu Thr
   1               5                  10                  15    
 Glu Gly Leu Arg Phe Leu His Thr Thr Val Gly Ser Leu Leu Ala Thr
              20                  25                  30        
 Tyr Gly Trp Tyr Ile Val Phe Ser Cys Ile Leu Leu Tyr Val Val Phe
          35                  40                  45            
 Gln Lys Leu Ser Ala Arg Leu Arg Ala Leu Arg Gln Arg Gln Leu Asp
      50                  55                  60                
 Arg Ala Ala Ala Ala Val Glu Pro Asp Val Val Val Lys Arg Gln Glu
  65                  70                  75                  80
 Ala Leu Ala Ala Ala Arg Leu Lys Met Gln Glu Glu Leu Asn Ala Gln
                  85                  90                  95    
 Val Glu Lys His Lys Glu Lys Leu Lys Gln Leu Glu Glu Glu Lys Arg
             100                 105                 110        
 Arg Gln Lys Ile Glu Met Trp Asp Ser Met Gln Glu Gly Lys Ser Tyr
         115                 120                 125            
 Lys Gly Asn Ala Lys Lys Pro Gln Glu Glu Asp Ser Pro Gly Pro Ser
     130                 135                 140                
 Thr Ser Ser Val Leu Lys Arg Lys Ser Asp Arg Lys Pro Leu Arg Gly
 145                 150                 155                 160
 Gly Gly Tyr Asn Pro Leu Ser Gly Glu Gly Gly Gly Ala Cys Ser Trp
                 165                 170                 175    
 Arg Pro Gly Arg Arg Gly Pro Ser Ser Gly Gly
             180                 185        



      <210> 333
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 333
 Met Ser Glu Lys Arg Arg Arg Leu Asp Ala Arg Asn Pro Leu Lys Gln
   1               5                  10                  15    
 Glu Thr Ala Leu Ser Arg Leu Pro Phe Pro Arg Gly Asn Gln Gly Leu
              20                  25                  30        
 Leu Gln Lys Ala Glu Ala Gly Arg Ala Arg Trp Leu Thr Pro Val Ile
          35                  40                  45            
 Pro Ala Leu Trp Lys Thr Glu Ala Gly Gly Ser Pro Glu Lys Met Thr
      50                  55                  60                
 Gln Asp Arg Pro Leu Leu Ala Val Gln Glu Ala Leu Lys Lys Cys Phe
  65                  70                  75                  80
 Pro Val Val Glu Glu Gln Gln Gly Leu Trp Gln Ser Ala Leu Arg Asp
                  85                  90                  95    
 Cys Gln Pro Leu Leu Ser Ser Leu Ser Asn Leu Ala Glu Gln Leu Gln
             100                 105                 110        
 Ala Ala Gln Asn Leu Arg Phe Glu Asp Val Pro Ala Leu Arg Ala Phe
         115                 120                 125            
 Pro Asp Leu Lys Glu Arg Leu Arg Arg Lys Gln Leu Val Ala Gly Asp
     130                 135                 140                
 Ile Val Leu Asp Lys Leu Gly Glu Arg Leu Ala Ile Leu Leu Lys Val
 145                 150                 155                 160
 Arg Asp Met Val Ser Ser His Val Glu Arg Val Phe Gln Ile Tyr Glu
                 165                 170                 175    
 Gln His Ala Asp Thr Val Gly Ile Asp Ala Val Leu Gln Pro Ser Ala
             180                 185                 190        
 Val Ser Pro Ser Val Ala Asp Met Leu Glu Trp Leu Gln Asp Ile Glu
         195                 200                 205            
 Arg His Tyr Arg Lys Ser Tyr Leu Lys Arg Lys Tyr Leu Leu Ser Ser
     210                 215                 220                
 Ile Gln Trp Gly Asp Leu Ala Asn Ile Gln Ala Leu Pro Lys Ala Trp
 225                 230                 235                 240
 Asp Arg Ile Ser Lys Asp Glu His His Asp Leu Val Gln Asp Ile Leu
                 245                 250                 255    
 Leu Asn Val Ser Phe Phe Leu Glu Glu
             260                 265



      <210> 334
      <211> 328
      <212> PRT
      <213> Homo sapiens


      <400> 334
 Met Arg Ala Leu Pro Gly Leu Leu Glu Ala Arg Ala Arg Thr Pro Arg
   1               5                  10                  15    
 Leu Leu Leu Leu Gln Cys Leu Leu Ala Ala Ala Arg Pro Ser Ser Ala
              20                  25                  30        
 Asp Gly Ser Ala Pro Asp Ser Pro Phe Thr Ser Pro Pro Leu Arg Glu
          35                  40                  45            
 Glu Ile Met Ala Asn Asn Phe Ser Leu Glu Ser His Asn Ile Ser Leu
      50                  55                  60                
 Thr Glu His Ser Ser Met Pro Val Glu Lys Asn Ile Thr Leu Glu Arg
  65                  70                  75                  80
 Pro Ser Asn Val Asn Leu Thr Cys Gln Phe Thr Thr Ser Gly Asp Leu
                  85                  90                  95    
 Asn Ala Val Asn Val Thr Trp Lys Lys Asp Gly Glu Gln Leu Glu Asn
             100                 105                 110        
 Asn Tyr Leu Val Ser Ala Thr Gly Ser Thr Leu Tyr Thr Gln Tyr Arg
         115                 120                 125            
 Phe Thr Ile Ile Asn Ser Lys Gln Met Gly Ser Tyr Ser Cys Phe Phe
     130                 135                 140                
 Arg Glu Glu Lys Glu Gln Arg Gly Thr Phe Asn Phe Lys Val Pro Glu
 145                 150                 155                 160
 Leu His Gly Lys Asn Lys Pro Leu Ile Ser Tyr Val Gly Asp Ser Thr
                 165                 170                 175    
 Val Leu Thr Cys Lys Cys Gln Asn Cys Phe Pro Leu Asn Trp Thr Trp
             180                 185                 190        
 Tyr Ser Ser Asn Gly Ser Val Lys Val Pro Val Gly Val Gln Met Asn
         195                 200                 205            
 Lys Tyr Val Ile Asn Gly Thr Tyr Ala Asn Glu Thr Lys Leu Lys Ile
     210                 215                 220                
 Thr Gln Leu Leu Glu Glu Asp Gly Glu Ser Tyr Trp Cys Arg Ala Leu
 225                 230                 235                 240
 Phe Gln Leu Gly Glu Ser Glu Glu His Ile Glu Leu Val Val Leu Ser
                 245                 250                 255    
 Tyr Leu Val Pro Leu Lys Pro Phe Leu Val Ile Val Ala Glu Val Ile
             260                 265                 270        
 Leu Leu Val Ala Thr Ile Leu Leu Cys Glu Lys Tyr Thr Gln Lys Lys
         275                 280                 285            
 Lys Lys His Ser Asp Glu Gly Lys Glu Phe Glu Gln Ile Glu Gln Leu
     290                 295                 300                
 Lys Ser Asp Asp Ser Asn Gly Ile Glu Asn Asn Val Pro Arg His Arg
 305                 310                 315                 320
 Lys Asn Glu Ser Leu Gly Gln
                 325        



      <210> 335
      <211> 361
      <212> PRT
      <213> Homo sapiens


      <400> 335
 Met Asn Tyr Thr Glu Ser Ser Pro Leu Arg Glu Ser Thr Ala Ile Gly
   1               5                  10                  15    
 Phe Thr Pro Glu Leu Glu Ser Ile Ile Pro Val Pro Ser Asn Lys Thr
              20                  25                  30        
 Thr Cys Glu Asn Trp Arg Glu Ile His His Leu Val Phe His Val Ala
          35                  40                  45            
 Asn Ile Cys Phe Ala Val Gly Leu Val Ile Pro Thr Thr Leu His Leu
      50                  55                  60                
 His Met Ile Phe Leu Arg Gly Met Leu Thr Leu Gly Cys Thr Leu Tyr
  65                  70                  75                  80
 Ile Val Trp Ala Thr Leu Tyr Arg Cys Ala Leu Asp Ile Met Ile Trp
                  85                  90                  95    
 Asn Ser Val Phe Leu Gly Val Asn Ile Leu His Leu Ser Tyr Leu Leu
             100                 105                 110        
 Tyr Lys Lys Arg Pro Val Lys Ile Glu Lys Glu Leu Ser Gly Met Tyr
         115                 120                 125            
 Arg Arg Leu Phe Glu Pro Leu Arg Val Pro Pro Asp Leu Phe Arg Arg
     130                 135                 140                
 Leu Thr Gly Gln Phe Cys Met Ile Gln Thr Leu Lys Lys Gly Gln Thr
 145                 150                 155                 160
 Tyr Ala Ala Glu Asp Lys Thr Ser Val Asp Asp Arg Leu Ser Ile Leu
                 165                 170                 175    
 Leu Lys Gly Lys Met Lys Val Ser Tyr Arg Gly His Phe Leu His Asn
             180                 185                 190        
 Ile Tyr Pro Cys Ala Phe Ile Asp Ser Pro Glu Phe Arg Ser Thr Gln
         195                 200                 205            
 Met His Lys Gly Glu Lys Phe Gln Val Thr Ile Ile Ala Asp Asp Asn
     210                 215                 220                
 Cys Arg Phe Leu Cys Trp Ser Arg Glu Arg Leu Thr Tyr Phe Leu Glu
 225                 230                 235                 240
 Ser Glu Pro Phe Leu Tyr Glu Ile Phe Arg Tyr Leu Ile Gly Lys Asp
                 245                 250                 255    
 Ile Thr Asn Lys Leu Tyr Ser Leu Asn Asp Pro Thr Leu Asn Asp Lys
             260                 265                 270        
 Lys Ala Lys Lys Leu Glu His Gln Leu Ser Leu Cys Thr Gln Ile Ser
         275                 280                 285            
 Met Leu Glu Met Arg Asn Ser Ile Ala Ser Ser Ser Asp Ser Asp Asp
     290                 295                 300                
 Gly Leu His Gln Phe Leu Arg Gly Thr Ser Ser Met Ser Ser Leu His
 305                 310                 315                 320
 Val Ser Ser Pro His Gln Arg Ala Ser Ala Lys Met Lys Pro Ile Glu
                 325                 330                 335    
 Glu Gly Ala Glu Asp Asp Asp Asp Val Phe Glu Pro Ala Ser Pro Asn
             340                 345                 350        
 Thr Leu Lys Val His Gln Leu Pro
         355                 360



      <210> 336
      <211> 306
      <212> PRT
      <213> Homo sapiens


      <400> 336
 Met Gly Thr Glu Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe
   1               5                  10                  15    
 Gln Ala Ala Val Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr
              20                  25                  30        
 Arg Pro Ser Tyr Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln
          35                  40                  45            
 Ala Thr Met Gly Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro
      50                  55                  60                
 Ile Gly Arg Tyr Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser
  65                  70                  75                  80
 Arg Glu Glu Ala Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala
                  85                  90                  95    
 Gln Lys Val Ile Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met
             100                 105                 110        
 Phe Gly Tyr Phe Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg
         115                 120                 125            
 Pro Pro Glu Thr Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val
     130                 135                 140                
 Val Asn Gly Asp Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys
 145                 150                 155                 160
 Glu Pro Ala Pro Pro Ser Pro Glu Ser His Ser Pro Arg Asp Leu Asp
                 165                 170                 175    
 Ser Glu Val Phe Cys Asp Ser Leu Glu Gln Leu Glu Pro Glu Leu Val
             180                 185                 190        
 Trp Thr Glu Gln Arg Ala Ala Ser Gly Gly Lys Arg Asp Pro Arg Asn
         195                 200                 205            
 Ser Pro Val Pro Pro Thr Lys Lys Glu Gly Leu Arg Gly Ser Pro Pro
     210                 215                 220                
 Gly Pro Gln Glu Leu Asp Val Trp Leu Leu Gly Thr Val Arg Ala Leu
 225                 230                 235                 240
 Gln Glu Ser Met Gln Glu Val Gln Ala Arg Val Gln Ser Leu Glu Ser
                 245                 250                 255    
 Met Pro Arg Pro Pro Glu Gln Arg Pro Gln Pro Arg Pro Ser Ala Arg
             260                 265                 270        
 Pro Trp Pro Leu Gly Leu Pro Gly Pro Ala Leu Leu Phe Phe Leu Leu
         275                 280                 285            
 Trp Pro Phe Val Val Gln Trp Leu Phe Arg Met Phe Arg Thr Gln Lys
     290                 295                 300                
 Arg
 305



      <210> 337
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 337
 Met Asn Phe Ser Gly Gly Gly Arg Gln Glu Ala Ala Gly Ser Arg Gly
   1               5                  10                  15    
 Arg Arg Ala Pro Arg Pro Arg Glu Gln Asp Arg Asp Val Gln Leu Ser
              20                  25                  30        
 Lys Ala Leu Ser Tyr Ala Leu Arg His Gly Ala Leu Lys Leu Gly Leu
          35                  40                  45            
 Pro Met Gly Ala Asp Gly Phe Val Pro Leu Gly Thr Leu Leu Gln Leu
      50                  55                  60                
 Pro Gln Phe Arg Gly Phe Ser Ala Glu Asp Val Gln Arg Val Val Asp
  65                  70                  75                  80
 Thr Asn Arg Lys Gln Arg Phe Ala Leu Gln Leu Gly Asp Pro Ser Thr
                  85                  90                  95    
 Gly Leu Leu Ile Arg Ala Asn Gln Gly His Ser Leu Gln Val Pro Lys
             100                 105                 110        
 Leu Glu Leu Met Pro Leu Glu Thr Pro Gln Ala Leu Pro Pro Met Leu
         115                 120                 125            
 Val His Gly Thr Phe Trp Lys His Trp Pro Ser Ile Leu Leu Lys Gly
     130                 135                 140                
 Leu Ser Cys Gln Gly Arg Thr His Ile His Leu Ala Pro Gly Leu Pro
 145                 150                 155                 160
 Gly Asp Pro Gly Ile Ile Ser Gly Met Arg Ser His Cys Glu Ile Ala
                 165                 170                 175    
 Val Phe Ile Asp Gly Pro Leu Ala Leu Ala Asp Gly Ile Pro Phe Phe
             180                 185                 190        
 Arg Ser Ala Asn Gly Val Ile Leu Thr Pro Gly Asn Thr Asp Gly Phe
         195                 200                 205            
 Leu Leu Pro Lys Tyr Phe Lys Glu Ala Leu Gln Leu Arg Pro Thr Arg
     210                 215                 220                
 Lys Pro Leu Ser Leu Ala Gly Asp Glu Glu Thr Glu Cys Gln Ser Ser
 225                 230                 235                 240
 Pro Lys His Ser Ser Arg Glu Arg Arg Arg Ile Gln Gln
                 245                 250            



      <210> 338
      <211> 265
      <212> PRT
      <213> Homo sapiens


      <400> 338
 Met Gly Gly Gly Lys Ser Gly Thr Val Ser Ser Gln Lys Gln Pro Ala
   1               5                  10                  15    
 Ser Lys Thr Ala Ser Asp Lys Thr Asp Ser Ala Leu Asn Thr Ala Thr
              20                  25                  30        
 Glu Ile Lys Asp Gly Leu Gln Cys Gly Thr Val Ser Ser Gln Lys Gln
          35                  40                  45            
 Gln Ala Leu Lys Ala Thr Thr Asp Glu Glu Gly Ser Val Ser Asn Ile
      50                  55                  60                
 Ala Thr Glu Ile Lys Asp Gly Glu Lys Ser Gly Thr Val Ser Ser Gln
  65                  70                  75                  80
 Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Lys Asp Ser Phe Ser
                  85                  90                  95    
 Asn Ile Thr Arg Glu Lys Lys Asp Gly Glu Ile Ser Arg Thr Val Ser
             100                 105                 110        
 Ser Gln Lys Pro Pro Ala Leu Lys Ala Thr Ser Val Lys Glu Asp Ser
         115                 120                 125            
 Val Leu Asn Ile Ala Arg Glu Lys Lys Asp Gly Glu Lys Ser Arg Thr
     130                 135                 140                
 Val Ser Phe Asp Gln Pro Pro Gly Leu Lys Ala Thr Arg Asp Glu Lys
 145                 150                 155                 160
 Asp Ser Leu Leu Asn Ile Ala Arg Gly Lys Glu Asp Gly Glu Lys Thr
                 165                 170                 175    
 Arg Arg Val Ser Ser Arg Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp
             180                 185                 190        
 Glu Lys Asp Ser Phe Ser Asn Ile Thr Arg Glu Lys Lys Asp Gly Glu
         195                 200                 205            
 Thr Ser Arg Thr Val Ser Ser Gln Lys Pro Pro Ala Leu Lys Ala Thr
     210                 215                 220                
 Ser Asp Glu Glu Asp Ser Val Leu Ser Ile Ala Arg Glu Glu Lys Asp
 225                 230                 235                 240
 Gly Glu Lys Ser Arg Thr Val Ser Ser Glu Gln Pro Pro Gly Leu Lys
                 245                 250                 255    
 Cys Leu Leu Gly Lys Lys Gln Pro
             260                



      <210> 339
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 339
 Met Val Asp Lys Lys Leu Val Val Val Phe Gly Gly Thr Gly Ala Gln
   1               5                  10                  15    
 Gly Gly Ser Val Ala Arg Thr Leu Leu Glu Asp Gly Thr Phe Lys Val
              20                  25                  30        
 Arg Val Val Thr Arg Asn Pro Arg Lys Lys Ala Ala Lys Glu Leu Arg
          35                  40                  45            
 Leu Gln Gly Ala Glu Val Val Gln Gly Asp Gln Asp Asp Gln Val Ile
      50                  55                  60                
 Met Glu Leu Ala Leu Asn Gly Ala Tyr Ala Thr Phe Ile Val Thr Asn
  65                  70                  75                  80
 Tyr Trp Glu Ser Cys Ser Gln Glu Gln Glu Val Lys Gln Gly Lys Leu
                  85                  90                  95    
 Leu Ala Asp Leu Ala Arg Arg Leu Gly Leu His Tyr Val Val Tyr Ser
             100                 105                 110        
 Gly Leu Glu Asn Ile Lys Lys Leu Thr Ala Gly Arg Leu Ala Ala Ala
         115                 120                 125            
 His Phe Asp Gly Lys Gly Glu Val Glu Glu Tyr Phe Arg Asp Ile Gly
     130                 135                 140                
 Val Pro Met Thr Ser Val Arg Leu Pro Cys Tyr Phe Glu Asn Leu Leu
 145                 150                 155                 160
 Ser His Phe Leu Pro Gln Lys Ala Pro Asp Gly Lys Ser Tyr Leu Leu
                 165                 170                 175    
 Ser Leu Pro Thr Gly Asp Val Pro Met Asp Gly Met Ser Val Ser Asp
             180                 185                 190        
 Leu Gly Pro Val Val Leu Ser Leu Leu Lys Met Pro Glu Lys Tyr Val
         195                 200                 205            
 Gly Gln Asn Ile Gly Leu Ser Thr Cys Arg His Thr Ala Glu Glu Tyr
     210                 215                 220                
 Ala Ala Leu Leu Thr Lys His Thr Arg Lys Val Val His Asp Ala Lys
 225                 230                 235                 240
 Met Thr Pro Glu Asp Tyr Glu Lys Leu Gly Phe Pro Gly Ala Arg Asp
                 245                 250                 255    
 Leu Ala Asn Met Phe Arg Phe Tyr Ala Leu Arg Pro Asp Arg Asp Ile
             260                 265                 270        
 Glu Leu Thr Leu Arg Leu Asn Pro Lys Ala Leu Thr Leu Asp Gln Trp
         275                 280                 285            
 Leu Glu Gln His Lys Gly Asp Phe Asn Leu Leu
     290                 295                



      <210> 340
      <211> 783
      <212> PRT
      <213> Homo sapiens


      <400> 340
 Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu
   1               5                  10                  15    
 Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg
              20                  25                  30        
 Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg
          35                  40                  45            
 Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys
      50                  55                  60                
 Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro
  65                  70                  75                  80
 Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val
                  85                  90                  95    
 Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu
             100                 105                 110        
 His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala
         115                 120                 125            
 Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val
     130                 135                 140                
 Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr
 145                 150                 155                 160
 Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe
                 165                 170                 175    
 Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val
             180                 185                 190        
 Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu
         195                 200                 205            
 Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile
     210                 215                 220                
 His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala
 225                 230                 235                 240
 Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala
                 245                 250                 255    
 Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln
             260                 265                 270        
 Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala
         275                 280                 285            
 Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser
     290                 295                 300                
 Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro
 305                 310                 315                 320
 Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His
                 325                 330                 335    
 Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr
             340                 345                 350        
 Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys
         355                 360                 365            
 Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly
     370                 375                 380                
 Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp
 385                 390                 395                 400
 Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn
                 405                 410                 415    
 Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala
             420                 425                 430        
 Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln
         435                 440                 445            
 Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr
     450                 455                 460                
 Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr
 465                 470                 475                 480
 Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala
                 485                 490                 495    
 Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln
             500                 505                 510        
 Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln
         515                 520                 525            
 Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met
     530                 535                 540                
 Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro
 545                 550                 555                 560
 Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr
                 565                 570                 575    
 Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp
             580                 585                 590        
 Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr
         595                 600                 605            
 Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val
     610                 615                 620                
 Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly
 625                 630                 635                 640
 Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg
                 645                 650                 655    
 Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys
             660                 665                 670        
 Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu
         675                 680                 685            
 Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp
     690                 695                 700                
 Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys
 705                 710                 715                 720
 Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala
                 725                 730                 735    
 Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu
             740                 745                 750        
 Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp
         755                 760                 765            
 Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala
     770                 775                 780        



      <210> 341
      <211> 256
      <212> PRT
      <213> Homo sapiens


      <400> 341
 Met Val Lys Leu Thr Ala Glu Leu Ile Glu Gln Ala Ala Gln Tyr Thr
   1               5                  10                  15    
 Asn Ala Val Arg Asp Arg Glu Leu Asp Leu Arg Gly Tyr Lys Ile Pro
              20                  25                  30        
 Val Ile Glu Asn Leu Gly Ala Thr Leu Asp Gln Phe Asp Ala Ile Asp
          35                  40                  45            
 Phe Ser Asp Asn Glu Ile Arg Lys Leu Asp Gly Phe Pro Leu Leu Arg
      50                  55                  60                
 Arg Leu Lys Thr Leu Leu Val Asn Asn Asn Arg Ile Cys Arg Ile Gly
  65                  70                  75                  80
 Glu Gly Leu Asp Gln Ala Leu Pro Cys Leu Thr Glu Leu Ile Leu Thr
                  85                  90                  95    
 Asn Asn Ser Leu Val Glu Leu Gly Asp Leu Asp Pro Leu Ala Ser Leu
             100                 105                 110        
 Lys Ser Leu Thr Tyr Leu Ser Ile Leu Arg Asn Pro Val Thr Asn Lys
         115                 120                 125            
 Lys His Tyr Arg Leu Tyr Val Ile Tyr Lys Val Pro Gln Val Arg Val
     130                 135                 140                
 Leu Asp Phe Gln Lys Val Lys Leu Lys Glu Arg Gln Glu Ala Glu Lys
 145                 150                 155                 160
 Met Phe Lys Gly Lys Arg Gly Ala Gln Leu Ala Lys Asp Ile Ala Arg
                 165                 170                 175    
 Arg Ser Lys Thr Phe Asn Pro Gly Ala Gly Leu Pro Thr Asp Lys Lys
             180                 185                 190        
 Lys Gly Gly Pro Ser Pro Gly Asp Val Glu Ala Ile Lys Asn Ala Ile
         195                 200                 205            
 Ala Asn Ala Ser Thr Leu Ala Glu Val Glu Arg Leu Lys Gly Leu Leu
     210                 215                 220                
 Gln Ser Gly Gln Ile Pro Gly Arg Glu Arg Arg Ser Gly Pro Thr Asp
 225                 230                 235                 240
 Asp Gly Glu Glu Glu Met Glu Glu Asp Thr Val Thr Asn Gly Ser
                 245                 250                 255



      <210> 342
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 342
 Met Leu Ser Leu Arg Val Pro Leu Ala Pro Ile Thr Asp Pro Gln Gln
   1               5                  10                  15    
 Leu Gln Leu Ser Pro Leu Lys Gly Leu Ser Leu Val Asp Lys Glu Asn
              20                  25                  30        
 Thr Pro Pro Ala Leu Ser Gly Thr Arg Val Leu Ala Ser Lys Thr Ala
          35                  40                  45            
 Arg Arg Ile Phe Gln Glu Pro Thr Glu Pro Lys Thr Lys Ala Ala Ala
      50                  55                  60                
 Pro Gly Val Glu Asp Glu Pro Leu Leu Arg Glu Asn Pro Arg Arg Phe
  65                  70                  75                  80
 Val Ile Phe Pro Ile Glu Tyr His Asp Ile Trp Gln Met Tyr Lys Lys
                  85                  90                  95    
 Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Lys Asp
             100                 105                 110        
 Ile Gln His Trp Glu Ser Leu Lys Pro Glu Glu Arg Tyr Phe Ile Ser
         115                 120                 125            
 His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Asn Glu Asn
     130                 135                 140                
 Leu Val Glu Arg Phe Ser Gln Glu Val Gln Ile Thr Glu Ala Arg Cys
 145                 150                 155                 160
 Phe Tyr Gly Phe Gln Ile Ala Met Glu Asn Ile His Ser Glu Met Tyr
                 165                 170                 175    
 Ser Leu Leu Ile Asp Thr Tyr Ile Lys Asp Pro Lys Glu Arg Glu Phe
             180                 185                 190        
 Leu Phe Asn Ala Ile Glu Thr Met Pro Cys Val Lys Lys Lys Ala Asp
         195                 200                 205            
 Trp Ala Leu Arg Trp Ile Gly Asp Lys Glu Ala Thr Tyr Gly Glu Arg
     210                 215                 220                
 Val Val Ala Phe Ala Ala Val Glu Gly Ile Phe Phe Ser Gly Ser Phe
 225                 230                 235                 240
 Ala Ser Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr
                 245                 250                 255    
 Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Phe Thr Leu
             260                 265                 270



      <210> 343
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 343
 Met Ala Ala Ala Thr Leu Thr Ser Lys Leu Tyr Ser Leu Leu Phe Arg
   1               5                  10                  15    
 Arg Thr Ser Thr Phe Ala Leu Thr Ile Ile Val Gly Val Met Phe Phe
              20                  25                  30        
 Glu Arg Ala Phe Asp Gln Gly Ala Asp Ala Ile Tyr Asp His Ile Asn
          35                  40                  45            
 Glu Gly Lys Leu Trp Lys His Ile Lys His Lys Tyr Glu Asn Lys
      50                  55                  60            



      <210> 344
      <211> 300
      <212> PRT
      <213> Homo sapiens


      <400> 344
 Met Glu His Phe Asp Ala Ser Leu Ser Thr Tyr Phe Lys Ala Leu Leu
   1               5                  10                  15    
 Gly Pro Arg Asp Thr Arg Val Lys Gly Trp Phe Leu Leu Asp Asn Tyr
              20                  25                  30        
 Ile Pro Thr Phe Ile Cys Ser Val Ile Tyr Leu Leu Ile Val Trp Leu
          35                  40                  45            
 Gly Pro Lys Tyr Met Arg Asn Lys Gln Pro Phe Ser Cys Arg Gly Ile
      50                  55                  60                
 Leu Val Val Tyr Asn Leu Gly Leu Thr Leu Leu Ser Leu Tyr Met Phe
  65                  70                  75                  80
 Cys Glu Leu Val Thr Gly Val Trp Glu Gly Lys Tyr Asn Phe Phe Cys
                  85                  90                  95    
 Gln Gly Thr Arg Thr Ala Gly Glu Ser Asp Met Lys Ile Ile Arg Val
             100                 105                 110        
 Leu Trp Trp Tyr Tyr Phe Ser Lys Leu Ile Glu Phe Met Asp Thr Phe
         115                 120                 125            
 Phe Phe Ile Leu Arg Lys Asn Asn His Gln Ile Thr Val Leu His Val
     130                 135                 140                
 Tyr His His Ala Ser Met Leu Asn Ile Trp Trp Phe Val Met Asn Trp
 145                 150                 155                 160
 Val Pro Cys Gly His Ser Tyr Phe Gly Ala Thr Leu Asn Ser Phe Ile
                 165                 170                 175    
 His Val Leu Met Tyr Ser Tyr Tyr Gly Leu Ser Ser Val Pro Ser Met
             180                 185                 190        
 Arg Pro Tyr Leu Trp Trp Lys Lys Tyr Ile Thr Gln Gly Gln Leu Leu
         195                 200                 205            
 Gln Phe Val Leu Thr Ile Ile Gln Thr Ser Cys Gly Val Ile Trp Pro
     210                 215                 220                
 Cys Thr Phe Pro Leu Gly Trp Leu Tyr Phe Gln Ile Gly Tyr Met Ile
 225                 230                 235                 240
 Ser Leu Ile Ala Leu Phe Thr Asn Phe Tyr Ile Gln Thr Tyr Asn Lys
                 245                 250                 255    
 Lys Gly Ala Ser Arg Arg Lys Asp His Leu Lys Asp His Gln Asn Gly
             260                 265                 270        
 Ser Met Ala Ala Val Asn Gly His Thr Asn Ser Phe Ser Pro Leu Glu
         275                 280                 285            
 Asn Asn Val Lys Pro Arg Lys Leu Arg Lys Asp
     290                 295                



      <210> 345
      <211> 359
      <212> DNA
      <213> Homo sapiens


      <400> 345
 attttccttc ctagtagaag tgttactgcc tgtaactagc tcaaaatacc aatgcagttt     60
 ctgcattctg ggttttggtt ttcctttttt gttttttttg gtttttgaaa atttggtttt    120
 ggcccccaag gtggaagaca agggggaaaa caaaacaaaa ggggaaaaat tgccccccgg    180
 gaaaaaaaaa atccccggcc caaaccccca ggaaaaccgg gaaaaaaagg gcccccccaa    240
 aaccctaaaa aaatttggga atttaaaaaa aaaagggggt aaaacaaggg ggccaagggg    300
 ggaaaaaaac tccgacccaa agggaacccc cgggcaaaac cctggaaata aaaaaaaaa     359



      <210> 346
      <211> 371
      <212> DNA
      <213> Homo sapiens


      <400> 346
 aatttacccc tgacgcggcg gcggccgacg ggaagctggg tgtgcttagg tcgtggtggc     60
 cccggtggtg gtgggctccg ggcgggctcg cgtcatcctg cccccgctgc gatgcattcg    120
 cggcgcccgg acggatttga tggcttgggc taccggggtg gtgcccggga cgagcagggt    180
 tttggcggcg ccttccctgc aaggtccttc atcaccgggt cggacctggg ccactgggtg    240
 acgactctga cagatatcgc ccggcaggcg caactctgca ctgtggcgtg aagagcccgc    300
 cctacggcgt gcccaccaac tgcaccccgt acgaaggccc cacggaggat ccctttgaca    360
 gtggcagtgg g                                                         371



      <210> 347
      <211> 381
      <212> DNA
      <213> Homo sapiens


      <400> 347
 gaataaacta aactacttac catgcatgac ccataaaaat ctaactgctc ctccctgatc     60
 tttccagctt cgccttactc ctgtctcctc tttacttact accctgcatc taagatggct    120
 tccctttgag tttctacaat acaccaaaat ctcctacctc agagattttg ttccctctat    180
 ctgaaatact cttctctgga ccctttggct ggctggctgc tccttcatgt tttgggttca    240
 gttgtcactt ccttaaaaaa gggtttcttg ggccgggcac agtggctcac agctgtaatc    300
 ccagcacttt gggaggccga ggtgggtgga tcataaggtc aggagatcaa gaccatcctg    360
 gccaacacgg tgaaaccttg g                                              381



      <210> 348
      <211> 411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(411)
      <223> n = a,t,c or g


      <400> 348
 atacacgcgc tggcttctgg catgggcact gtcttttcct taaggtgaag ctcagagagt     60
 ggtcgtgggc gagggccgac aggcatctct ggctcctcct catcctcttc tcctgtagat    120
 tctggggtgg ggtaggggct cttatcctca ttttcattgg gctggagggc atccatgttg    180
 atcttggagg cgggtggaga ctctccgtca gccgtgatgg atttcagctc aatcttctcc    240
 tccttggatt cccccactgc cggctcatcc accaaactct tgcttcttct ctgggctggc    300
 agtcccgggc agcttctttc tctcattctc ctcttcctcc tccctttggg cacaagcgag    360
 gctctccaca ttagaccagg tgtccacacg caatggccct caatccactc n             411



      <210> 349
      <211> 451
      <212> DNA
      <213> Homo sapiens


      <400> 349
 aaaattaaca ctgagttaca aactgaagtg gcaatgttga aatccatggt tctgtggtta     60
 ggagaacagg tacaaagctt gcagttgcag cagcaattgc gtcatcattt taatcacatt    120
 catatttgcg taactaactc agaatataac caaagtgagt atccgtggga ccttgtgaaa    180
 gcccatttgc aaggagcttt cacatccaac atcacctttg atactggtga attccaaaac    240
 actattattg attcaactaa gtgaccgcat gatttatagg cttctttaga tgactgctcc    300
 tgaatttagg atggcctgtc catactcgcc tctgtactta tgttagctgc ccctgtcctg    360
 gcacttcaaa ctccgtcttg gatgctattt atggctcttc ctgtatccct ctcacgtctg    420
 aaggcctact ttctggtctc agtcttatcc c                                   451



      <210> 350
      <211> 549
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(549)
      <223> n = a,t,c or g


      <400> 350
 tgcatggccn ggagggctgg gccgctcgag cacgatgatt gagtcacgat ntgcagggtc     60
 cacccacgcg tccgattaaa tcctgcatgt aatatatctg ctgtcatctt agttggacca    120
 acttcccatt tatttatctt aaaactatac agttacgtct taattccatc caaagaagat    180
 acagtttgaa gacagaagtg tactctctac aatgcaattt actgtacagt tagaaagcaa    240
 agtgttaaat ggagaagata cttggattta ttaaacattg tgagatgtaa agatgctaca    300
 ttttaactga atgactagag tgattatctt ttttcccccg aagttagtcg taaatctttt    360
 gggttggaaa gaatgctcta catgaggatg aatagaacac agagaggcga acagatgata    420
 tccctgtttg tgaccatgaa ttcctgaaag tggaccaagg aacacttttt gaactcattc    480
 tggctgcaaa ctacttatac attagaggtt ggcttgatgt tacatgcaag actggtgcca    540
 atatgatcn                                                            549



      <210> 351
      <211> 542
      <212> DNA
      <213> Homo sapiens


      <400> 351
 agaagaaaaa ccttgatcgc ccctaggtag tcccgcctgc aggaattcgg cacgaggtca     60
 cgtggtgcag agcacgcaga gtccttctgt cggttggtcc tggagcggcg cagccggagt    120
 ggggccgtga ggagaataaa ggcagccccg ttgatgactg aaaatgacaa agcatccacc    180
 taacagacga ggaatcagct ttgaagtggg agcccagttg gaagcccggg accgtttaaa    240
 aaactggtat ccagctcaca tagaagacat tgactacgag gaaggaaaag tactcatcca    300
 tttcaagcgt tggaaccatc gttatgatga gtggttctgc tgggacagtc cttatttacg    360
 ccctttagag aaaatacagc tgaggaaaga gggcttgcat gaagaggatg gatcttctgt    420
 gagtaacaaa tctgggaagt tctgtagtat gcaaggtcag ccattgggct gcttgtgttt    480
 caatctttga tgttagtagc agctggagac cagttcttat ttaggcctat agttgtaacc    540
 ct                                                                   542



      <210> 352
      <211> 403
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(403)
      <223> n = a,t,c or g


      <400> 352
 agctttcttt ccttctctaa tatgtctatt ttgaaagtta ttccttggtt tccctatctt     60
 acatggctcc tcttctcccc cttgattgaa ggtccctagt ttaactcata aagtatcagc    120
 attagtaagc agtaattctt tctgagtgat gtacttagtg atctttcata tgaatatgaa    180
 ggtggcctgg cgcagaggct cactcctcca ctcattccag ctgggatttt acaaatccca    240
 gcactttggg aggccgaggt gggcggatcg cctgaggttg ggagttcgag accagcctgg    300
 ccaacatggg gaaaccccat ctctactgat ncaaaaaaag attaaaaagg gggggcggcc    360
 ctttaaaaga aaccaagttt actaacccgg gcatggcaat gtt                      403



      <210> 353
      <211> 405
      <212> DNA
      <213> Homo sapiens


      <400> 353
 gatcttgctc tgtcgcccag gctacagtgc agtggtgcaa tcacggccca ctgcagcctc     60
 gacctccgga gctcaattga tcctcccacc tcagcctcct gagtagctgc atctacagat    120
 gtgagccacc aaaaaaaaaa aaaaaatttt ttttgacaca ggatttaccc ttgtggccca    180
 ggctgaaggg ctttgggcct cactgaaagt ttttcttgag ctaaaaccac cctttcactt    240
 taccctccca gggagggggg attaaagcct cactccaccc ccccgggcct tgtttttctt    300
 ttggaaacat cgttctacaa ggcgggggga acatcgtttt ttaaataaga agtttttttg    360
 gaaagttaat aaacccagtt ggggcctggg aggaaaacac ccaga                    405



      <210> 354
      <211> 877
      <212> DNA
      <213> Homo sapiens


      <400> 354
 gcgatctgct tacgccaatc ttggtacgag gggcataaat attctaacgg ttaattttag     60
 acatctactt gactggatta agagacacac atagctggtc aaacatgatt tcagccatga    120
 atcaggcata aatattctga tggttaattg tagacatcta cttgactgga ttgagagaca    180
 cacatagctg gtcaaacacg atttcagcca tgaatcaggc ataaatattc tgatggttaa    240
 ttgtagacgt ctacttgact ggattgagag acacacatag ctggtcaaac acgatttcag    300
 ccatgaatca ggcataaata ttctgatggt taatcgtaga catctacttg actggattga    360
 gagacacaca tagctggtca aacacgattt cagccatgaa tcaggcataa atattctgat    420
 ggttaatcgt agacgtctac ttgactggat tgagagacac acacagctgg tcaaacacgg    480
 atttctgggc atatctatga gggcgtttct ggaagacact gagataacca tgacccaatg    540
 tggatgggca ctgatatggt ttggctgtgt ccccacccag atcctcatct ttgaattgta    600
 gtttcctgta aatacctaca tgtcgttggg agggacccca atgggagggt gacctgaatc    660
 gtggtggtgg ttaccgccat gctgttctca ttgacaagtt gagttgaggt tctcaatgat    720
 ctgatgggtt tttataaggg ggcttttccc ctttgggtca gcacttcttg ttgctgccat    780
 gtgaagaggg attagctttg cttccccttc tgccatgatt gtgaggccct tgcagccatg    840
 tggaactgtc agcccattaa acccctttgt tctttat                             877



      <210> 355
      <211> 803
      <212> DNA
      <213> Homo sapiens


      <400> 355
 cgcggccgcg tgaggacgag gctatttgaa aacacgctcc gggagctaga gcctgaggtc     60
 ggcggcgcac gctgttgccc cgtgggcttc tgctccctcg cttgtcttct cgggcttctc    120
 gccccggccg cggccgggtc ctcagtagtc gagaatgact aaaaaaagaa aacgccaaca    180
 tgattttcaa aaagtaaaat tgaaagttgg taaaaagaag cccaagttac aaaatgctac    240
 tcctacaaac tttaaaacaa agactataca tctgcctgag caactcaaag aggatggaac    300
 acttccaaca aacaatagaa aacttaacat aaaggatttg ctgtcacaga tgcatcacta    360
 caatgctggg gttaaacaaa gggctcttct tggacttaaa gaccttttgt ctcaataccc    420
 atttataatt gatgcacacc ttttaaacat attaagtgaa gtgactgctg tgtttacaga    480
 taaagatgct aatgtacgat tagcagcagt tcaacttctt caattcctgg cccccaaaat    540
 acgagctgaa caaatttctc cattttttcc tttggtaagt gcccatctct ctagtgccat    600
 gactcacatt actgaaggaa ttcaggagga ctctttaaaa gttttggaca ttctgctgga    660
 acagtaccca gctctaatta ctggccgtag cagcatattg cttaagaatt ttgtagaact    720
 tatttctcat cagcagctgt ccaaaggact ggataaatag agacagatcc cagtcctgga    780
 tactttctgt aaatcctaat cgg                                            803



      <210> 356
      <211> 369
      <212> DNA
      <213> Homo sapiens


      <400> 356
 attgtccgga gttcggagag tttgcttgtc cctttggctg gagggcctct ctgggctggg     60
 gatcacctca ggcgctgttc ttcattgagc gagcccttat ggaccccgag gactaatggt    120
 taccgggaga gatggctgtg gagccgccgg cggaccgcct tcaagaacca ctgaccttcc    180
 gggatggggc tgaggacttt acccaggagg aatgggggca gctggaccct acccagagga    240
 tcctctaccg tgacgtgatg ctggagacct ttgatcacct gctctccata ggtcctgagc    300
 ttacgaagcc tgaagacatc tcccagctgg agcaaggcac cgatctatgg gtggctgaga    360
 cactaacca                                                            369



      <210> 357
      <211> 2761
      <212> DNA
      <213> Homo sapiens


      <400> 357
 ttggacacaa aatatgttat ttattgtcaa tttctgcaaa gacacattta agcaacaaaa     60
 tatacatttg tcaacctttt agaatttgtt ttgtacatta acaaatacaa tgtgctacca    120
 tagcaataaa ttaaatgtac attatttaca ttacataggc agttggggat ctacgaatca    180
 cctcctcact aagaggaaag aaagcaaagt cgtcgtcaca tggagcatca cttccaagcc    240
 acagttctta ggttcgacca cacaggggaa tctgcacatt cacacgccag cagtccccga    300
 gctggagtgt ccaaggggaa acacccaaaa caggagagag ctgcacgcat gctaaggagc    360
 aggaagccgg gggggggagg gtagttcaca cttccaagca gaaatgtcac aaaatcaaag    420
 acgatggcaa ttaaattcca gtcttccagc caaatgtccc cctccccagg gctggtaagg    480
 cacaggacag agccgctgcc ccacagcctc tcactcggca gggctctgct gcccttggcc    540
 ctagtggggc ttgtcttctt cctcccaaag gggcacacgg tccagctgaa gggagggaga    600
 catgggattg gggtgtacaa ggggctggcg gtaaaacaga gtttggtaaa agaatacccc    660
 agccagcccc accaggctgc aggatcaggc ttggcaaact ttactggcct ccccttgcct    720
 cgatacaggg tagctagagg ctgggggagg agccgagggg tcctgagcat ggctgactgg    780
 cctggtccct gctggcctcc tgtacccatg agatctactc gaacccccaa ctgcttaaaa    840
 cagatctgtc tctactgact tagaaaccaa tgagaaaggt agtgtttgag ttggcacctg    900
 gcagggtcag ggaggaaagc gaaacaggct cttgtcctgc cttgtcacgg gagcctgagt    960
 ttctattaac caccttcgtt taagaatcag ggagaaatga agagtttttc tttgaccact   1020
 tttcctctta atttaggaaa agggaagctg agggtgggtg aacagcatct ttttccctgg   1080
 cctctgcccc cattacacag cccccatcag gagctgaaga accgatccca ctgaggaata   1140
 gttcactgaa tccctttccc tcctcgtttt cttggttcaa gctgcatcca aagcccaagg   1200
 gtcctcactg aaaaatccta gagactatcc cccctgatga aaaagagcag aaactgcagc   1260
 ctcaccagca tccttgactg ctcacctcca tgccagtgcc aaagcagcag ctaactggct   1320
 tccccaaaac ccagggcccc aggaaacgca gccacttatt caaccaacca tgtaggcgct   1380
 gcagaggaag ggaccctggg ttgagggttc taatcccagc tttgccaaca gccagctgtg   1440
 tgacctcaag caagttattc ccctcacctg ggctaagatt tctcatctgg acgatgacat   1500
 ggttggatga gatgctaaaa agagccagca ggcttgtgtt gaaatgatgc tgacaaagct   1560
 gaaccactga atctttttca agaaacgtca ttttacatga ctggcataga cagacactct   1620
 cattaagacc ttccatcgcg agcttttctg cacctgtttt taagcgtcaa ctgagctgga   1680
 ggcatatggg tgaccctaca gtgcctgaaa agtagtttct tcagtgagtc aggcagttcc   1740
 cagagccaga gatgtgtccc ggaaaacatc ccctcgtgga gatcacagtg gaaatgcctc   1800
 aaacaccagc gtgggcacca tctagatgag cctagtcacg agggccaatg aggtttgggc   1860
 aaatctttga gccccaagac tgggcgcagc ataaaaggaa agacatttta gatcagagca   1920
 gatgtaggga cagcgtgggg gaaacagccc tccaggaacc cgagctgccc gccccgtggt   1980
 ctaggggagg gaggggaggc tgggccatcc ttgttctcct cctccctctc agcactgccc   2040
 gggtgggctg gaagtgcaca ctctggaagc cacaggatgg agctcccaga gatagtgagg   2100
 catgaccaga gggaagaggc atttggggtc ctgttcagat cattccaaca gcaaaccggg   2160
 catggagacc ccatctcagg tctgtgcttc tctgggggcc acccagccat cctgcccacc   2220
 agctcagagg cagggacaaa gccctcccaa gaggcagcag gcagcaaggg tcagccagcg   2280
 cagtggggac aggcaggtat gggattccca aatgggacag catgctgaca acctggaaac   2340
 cccaaaggac cccagatggc aatgtgacac ggcccatcca ccaagcacct gtaatgccgg   2400
 cttcccacag aggcaagcca gatcctgcaa ctgttcttaa agaaatgcag tttgaccttg   2460
 ccagtgcctc cagaagccca gccaacaaaa cgcgtccaga acgtacgggc ctctttccag   2520
 ccgtgggggc tgctacggtg actcttcata aaagctaaac agatattttg ttgaccttct   2580
 aacaagaata aattttacta gactagtact ttagagaaag tactagcgaa gggagagctc   2640
 ctctccagct tgcaaacagg actcaatcat tcccacacac gtggcgggga agaaagatca   2700
 caatgttgct tgaatggcaa aagctatagg gagaatttca caatgtcagt taaaaaaaaa   2760
 a                                                                   2761



      <210> 358
      <211> 1646
      <212> DNA
      <213> Homo sapiens


      <400> 358
 ggacgcgtgg gcggcctcta gtgcactttc ggctccttcc ccttcccggg cctttcagct     60
 tggtctttcc gggcctcgct tcccccagcc cctgcgcccg gcccgaacga gaggttccgg    120
 agccccggcg cgggcgggtt ctggggtgta gacgctgctg gccagccctc cccagccgag    180
 gttctcggca ccgccttgag agcttcagct gccccagggt gtgcagatta gaatcccaag    240
 aaaatcaaat ggcatccggg gatttctgct cacctggaga agggatggaa atacttcaac    300
 aagtgtgcag caaacaactt cctccttgta acctgagtaa agaggacctg ttacagaacc    360
 catacttcag caagcttctc ctgaatctct cacagcatgt ggatgagagt ggcttaagcc    420
 tcaccctagc aaaggagcag gctcaggcat ggaaggaagt tcgactgcat aagacaacat    480
 ggttgaggtc tgagatttta cacagagtca ttcaagagtt gcttgtggac tactatgtga    540
 agatacaaga cacaaatgta acttctgagg acaaaaagtt tcatgagacc cttgaacagc    600
 ggctgcttgt aactgaactg atgcggctct taggtcctag ccaggagagg gagatacctc    660
 cactgctggg gctggagaaa gcggaccttc tggaactcat gccactctca gaggattttg    720
 tgtggatgag ggctcggcta cagcaagaag tagaggagca gctcaaaaag aaatgtttca    780
 ctctgctctg ctactatgat cccaattcag atgctgacag tgaaaccgtg aaggcagcaa    840
 aggtgtggaa actcgcagag gtcctggtgg gtgagcagca gcagtgccag gatgccaaga    900
 gccagcagaa ggagcagatg ttgctgctgg agaagaagag tgctgcttac tcccaggtgc    960
 ttctccgctg cctcactttg ctgcagaggc ttcttcaaga acaccggctg aagactcaat   1020
 ccgagctaga ccgcatcaat gcccagtacc tggaagtcaa gtgcggtgct atgatcctta   1080
 agctgaggat ggaggagcta aagattttgt ccgacactta cactgttgag aaagtggaag   1140
 ttcatcgtct gattagggac cgtttggagg gagccattca cctacaggag caggacatgg   1200
 agaactcaag acaggtcctg aactcctatg aggtccttgg ggaggagttt gacaggctgg   1260
 tgaaagagta caccgtactc aagcaggcaa cagagaacaa gcggtgggcc ctccaggagt   1320
 tcagcaaggt ctaccgttga gctctggcag ggccaggaga catggcttct gcatagctgc   1380
 tgcctcctaa tcttcctgct agtgggacca ccttcacctg gggctgcctt cagtacaagg   1440
 gagtgtggaa atgcttacgc ttgaaacact gcagtcattt aggcactctc ctggtttctc   1500
 tttatttttt atgactgggc ctcttctgga aaatctagca aggagattta tataattttt   1560
 atgcatagct gtgtgtcagt gtcagccctg tattgtattt gattatctcc tgaataaagt   1620
 tatgatatta tatcttaaaa aaaaaa                                        1646



      <210> 359
      <211> 407
      <212> DNA
      <213> Homo sapiens


      <400> 359
 aaaagaccta gtgtgccaaa aatgaatgtc aaggtgggca ggtggagtca ggtagttttt     60
 aggccattta tttgtaaaca gttattttat ctatgcgtct atctgtctgt ctgtctgtct    120
 atctatctat ctgtctatct atctatctat ctatctatct atctatctat ctatctatct    180
 atctatccct ccatccatcc atccattcaa ctggcatcta tttaatctat ttttctttgg    240
 ggttaaatta tgaaagagca cggagagaat agatttatta actataaaga cagggaataa    300
 ttgataacat aacatccctg agaaaattga agaggatgat atacaaaaac aaaatcattt    360
 atttttggat ggagggtata ggtagagggg tctgtcattg tattggg                  407



      <210> 360
      <211> 1236
      <212> DNA
      <213> Homo sapiens


      <400> 360
 cgaaaaatgg cggggtctcc tgagttggtg gtccttgacc ctccatggga caaggagctc     60
 gcggctggca cagagagcca ggccttggtc tccgccactc cccgagaaga ctttcgggtg    120
 cgctgcacct cgaagcgggc tgtgaccgaa atgctacaac tgtgcggccg cttcgtgcaa    180
 aagctcgggg acgctctgcc ggaggagatt cgggagcccg ctctgcgaga tgcgcagtgg    240
 acttttgaat cagctgtgca agagaatatc agcattaatg ggcaagcatg gcaggaagct    300
 tcagataatt gttttatgga ttctgacatc aaagtacttg aagatcagtt tgatgaaatc    360
 atagtagata tagccacaaa acgtaagcag tatcccagaa agatcctgga atgtgtcatc    420
 aaaaccataa aagcaaaaca agaaattctg aagcagtacc accctgttgt acatccactg    480
 gacctaaaat atgaccctga tccagcccct catatggaaa atttgaaatg cagaggggaa    540
 acagtagcaa aggagatcag tgaagccatg aagtccttgc ctgcattaat tgaacaagga    600
 gagggatttt cccaagttct caggatgcag cctgttatcc acctccagag gattcaccaa    660
 gaagtctttt ccagttgtca taggaaacca gatgctaaac ctgagaactt tataacacag    720
 atagaaacca caccaacaga gactgcttcc aggaaaacct ctgacgtggt actgaaaaga    780
 aagcaaacta aagactgccc ccagagaaaa tggtatccat tgcggccaaa gaaaattaat    840
 cttgatacat gagctctttc tgtttatttt gggagttgaa aataggcacc atcaacattt    900
 agattacagc ctaattaata cctagataag acttcatttg aaataagaaa taactctttt    960
 actagtgatt catttataca gatataatat ctctgtgcgg ggatatgata taatattgta   1020
 tttccttact gttttatcta ttgtaaataa aaagcatttt aaaaagtatt gacacaaagc   1080
 ccatcagtgg gcattaaaaa tattaaaagt gcagactttt tactggtcct ttaagtgcca   1140
 tcaactctca gctcccttgt agcttttgtg gggatttaac aagtaacaaa ttctgttgtg   1200
 tttccaatgg tatacatctt tctaggaaaa aaaaaa                             1236



      <210> 361
      <211> 2353
      <212> DNA
      <213> Homo sapiens


      <400> 361
 gctgacaaag gagcggagga gcagtcgcag ctgctttccg aggaagccgg tgttgccgag     60
 attgccaaaa tgctttggag tttttaactg aatctaagaa aagtccaaaa tagatttgag    120
 actgtaaaaa cagaaactgc agcaaggggg attcagtgcc aatgcatcaa caaaaaagac    180
 aaccagagtt agtggaagga aatcttcctg ttttcgtgtt ccccacggag ctcatatttt    240
 atgcagatga tcagtcaaca cataagcaag tgttgacact gtacaatccc tatgagtttg    300
 ccttaaagtt caaagttttg tgtactactc caaataagta tgttgtcgtt gatgctgcag    360
 gtgcagtaaa gcctcagtgt tgtgtggata ttgtgattcg tcatcgagat gttcgatcct    420
 gtcactatgg tgtaatagac aaattccgtc tccaagtttc cgagcaaagc caaaggaagg    480
 ctttgggaag aaaagaggtt gttgctactc ttctcccatc agcaaaagaa caacaaaagg    540
 aagaagagga aaaaagatta aaggaacatt taactgaaag tttatttttt gagcagtcgt    600
 ttcaaccaga aaacagagct gtatcctcag gacctagttt actaactgtc ttcctgggag    660
 tggtgtgcat tgcagccctg atgctgccta cactggggga tgtggaatcg ctggtgcctc    720
 tctacctcca cttaagtgtg aatcaaaaat tagtggctgc ttatatctta ggtcttatca    780
 caatggccat acttagaaca tgagcaagga tttcaattga cttctgaagt aaatctgtct    840
 tgaaaatatg aatgtggact gccttttatc tctatttcac tccattaaca tgcaacaaac    900
 tattgaatga tttcaaataa ttgcaaatgt ataatatata ttttaaatta taatttaatt    960
 tgaaggactg cagaacatta ttttacagac agcaaggatg cttctgagtg acacctagga   1020
 aattatttga agaaattctt tttatatcta cacctgttgt gtaagaaact ttaaaacatt   1080
 ggttattttc tcaccttttt ttctaattca ctttgattgc taggggtcat gtatgcttcg   1140
 aagttacagg actaaaagag caaactgacc ggcctaaaac taaaatgaca tttattccct   1200
 agctacaaac atcagcgtta ttatgttaat tataccttgc cctctatcat tataaatggt   1260
 tgccatggtg tttctaaaaa taagtgtttt accattaatg tgtagagggc aaacaaagca   1320
 taaagtacta agggatcatg cttatcctag ggtctcacag aagagaggac atatttaatt   1380
 aatcttgtga attacagaac aggttgtggt ccagacacca agaatcatag gggttttttt   1440
 ttaaaaaacc taatagaagt agggtgacct ctctctttgg tctaagagtt ctaaaggaag   1500
 gtaggcatct gtttaattag ttggttcacc ctggctttac ctctggttaa tgctttgtgt   1560
 taataggaag gaaaaatcac tttatctttt cttccaagcc cctccctgcc tgacttaccc   1620
 agactgggat taccagatac caggtgattt atgtggagat gatttttcac ctttaaactc   1680
 taagccaagt gtaagaaact cttgatagct atgtctattt tatatcagtc actgagactt   1740
 tttttttaag tttttattta ttattaagac aactttgcca aaaaagtccc ctaagcacaa   1800
 ctatttacat ttctttatag cctcttctga tctctaacac atatgcagtt ttaactgtta   1860
 ttttcatagt aactgatctt ttgtctaagg atttttacct gaaagcacaa tgtattgagt   1920
 ctcttgaaaa tcatctttca gatcttttta cagaatgaac ttatgcactg ctactgtagt   1980
 attctcaagg aatatatgta aacacaaatg tatgcctgag gttggttttt gcagaaaacc   2040
 agtctctggc ttcttaaaaa cttctatgtc tagtcttcca taggaaatcc ctcactgttt   2100
 aaccatgtga ggagcctaag tcccctaagt cattaaacgg aatcatgtct gtacattgtg   2160
 taatgaatga aaagcacata aatgtaatct actttgaact ttgtaaaaat gatgtgtgga   2220
 ggctattctt gtttctccat ctcaagtcct gtgtgtgcac gtgtgtgcaa gtgcacatgt   2280
 gtgtgtgtaa taacacattg taaagaacag aaattacttt aaaaaataaa cagaaatgga   2340
 gacctgaaaa aaa                                                      2353



      <210> 362
      <211> 2304
      <212> DNA
      <213> Homo sapiens


      <400> 362
 ctgccgagga tccgagggtc aggctgcaga agcccagaat cccaccccag tccccaagta     60
 cagaggtgag gggaagcgag gcgaacgagg ggacgtcccc cgacccccta gccgcagctc    120
 ggccggggcg tccgtgacgt cagcacgacc gtttgtggga ggcggaggcc cctgctgtcg    180
 gggttcggaa tgagagcggc tccgggtcgc ggggttcact ggcctcctct tgagcttccc    240
 aacccacctt gggctccgtg ttgggcatgg ctaaggcgga gatgggcgga acttgtggga    300
 agttcgacag ctcctccgct gtgaaacttg gcgtctaagt catcccgtgg tttctatgga    360
 ggtgcggccg aagggaggct ctgtcgtcgc ctaagcaatc gccccacctg cgctgaggtc    420
 gctgtcaaga tggagtttcc aacccagtaa atccaagggc cagaccgtga cctcataaag    480
 catgatctcc ttctgtccag actgtggcaa aagtatccaa gcggcattca aattctgccc    540
 ctactgtgga aattctttgc ctgtagagga gcatgtaggg tcccagacct ttgtcaatcc    600
 acatgtgtca tccttccaag gctcaaagag agggctgaac tccagttttg aaacctctcc    660
 taagaaagtg aaatggtcca gcaccgtcac ctctccccga ttatccctct tctcagatgg    720
 tgacagttct gagtctgaag atactctgag ttcctctgag agatccaaag gctccgggag    780
 cagaccccca acccccaaaa gcagccctca gaagaccagg aagagccctc aggtgaccag    840
 gggtagccct cagaagacca gctgtagccc tcagaagacc aggcagagcc ctcagacgct    900
 gaagcggagc cgagtgacca cctcacttga agctttgccc acagggacag tgctgacaga    960
 caagagtggg cgacagtgga agctgaagtc cttccagacc agggacaacc agggcattct   1020
 ctatgaagct gcacccacct ccaccctcac ctgtgactca ggaccacaga agcaaaagtt   1080
 ctcactcaaa ctggatgcca aggatgggcg cttgttcaat gagcagaact tcttccagcg   1140
 ggccgccaag cctctgcaag tcaacaagtg gaagaagctg tactcgaccc cactgctggc   1200
 catccctacc tgcatgggtt tcggtgttca ccaggacaaa tacaggttct tggtgttacc   1260
 cagcctgggg aggagccttc agtcggccct ggatgtcagc ccaaagcatg tgctgtcaga   1320
 gaggtctgtg ctgcaggtgg cctgccggct gctggatgcc ctggagttcc tccatgagaa   1380
 tgagtatgtt catggaaatg tgacagctga aaatatcttt gtggatccag aggaccagag   1440
 tcaggtgact ttggcaggct atggcttcgc cttccgctat tgcccaagtg gcaaacacgt   1500
 ggcctacgtg gaaggcagca ggagccctca cgagggggac cttgagttca ttagcatgga   1560
 cctgcacaag ggatgcgggc cctcccgccg cagcgacctc cagagcctgg gctactgcat   1620
 gctgaagtgg ctctacgggt ttctgccatg gacaaattgc cttcccaaca ctgaggacat   1680
 catgaagcaa aaacagaagt ttgttgataa gccggggccc ttcgtgggac cctgcggtca   1740
 ctggatcagg ccctcagaga ccctgcagaa gtacctgaag gtggtgatgg ccctcacgta   1800
 tgaggagaag ccgccctacg ccatgctgag gaacaaccta gaagctttgc tgcaggatct   1860
 gcgtgtgtct ccatatgacc ccattggcct cccgatggtg ccctaggtgg aatccaggtg   1920
 ggaagagctt gtgaggctta agcctctcgc cccttgccct cacccgagcc ctgccccagg   1980
 ctccaggaga cacttcccag aggctgttcc acgttcatac cagggcccag cttcccaggg   2040
 agacactggg tttttccgca cggtccttga acttcccagc ctcaaggaat ggcaagtagc   2100
 agaaacccgg ctcaacttgg ctttaaaaaa agtggggatt gattggctgt tgtagctaga   2160
 aaattacaag ggggagcttc aggcacaacg ggattcaggg cctcaaaaat agcatcaaga   2220
 cgttggttgt ctctcgccat cttctgtccc ttcttgcatc catgcctccc tctgtccttc   2280
 cacccggcca cctgtagtct ctac                                          2304



      <210> 363
      <211> 3827
      <212> DNA
      <213> Homo sapiens


      <400> 363
 tttttttttt ttaggattat tctattttta tataagtcaa aagtgagcaa aaatgtaaac     60
 acaatattgt tatacacata acttggtaaa ataattcatt aaaaggacag agggagaatt    120
 accatacgtc aggatagtta gctctggggg aaacagtgag tgtcaagagg ggacacacag    180
 agattttgga gtgctggcaa gacctcctct gcatctagtt tgtgattaca cagctgttgc    240
 tttacccatt aagctctgtt ttaagtactt atttgtaagt tatatttcac aaaatttaaa    300
 agaacaaggg agaacctgtg tactaccaaa tattaacacc aattaaagcg ataattattg    360
 acagtgtaga aaaaacccag aaggcccaga aattggccta agacacaaaa gacacataag    420
 aatttaatat tctataaaaa tagcattact aatcagaggg gaaatggtgg tttcacatac    480
 tgaaccaatt ggtaaattct tcgaaataaa atcaaatccc taccttatat aatataacca    540
 aatacatttg agatggatta aaaatttcct tttcacccca aacttgtact gatttagtta    600
 atgtatataa acaaaattta aattcctttt aaagataggt gtaaaagtga aataagaaaa    660
 tactagaaga aaataaggac atttatccat tcttggatta caaaaatact ttcaagcaca    720
 tacacaaagg tagactccta aagaaaacaa cttctatact gaaataccac aaactatgtt    780
 aaatgacaaa taaggctaaa aaaagttaca atatatgaca aaggacggac attcttaaga    840
 acttatatgc caaaaaaaga gcaaattctc caagcaagca acagaaaaaa tatgaatgag    900
 caattctcaa aagaatgaat atagcatggc caatgaatat gaaaaaaaac acaaccttca    960
 ctaagtaaga aaaacaaata caaattttaa atgtagccct tttctgtaat tattcaattt   1020
 gcaaagattt taagtagtaa ttttcaattc tgagcattgg atatattgct aatgggaatg   1080
 taaatgaaca tgatctctgc agtgagtaat atatataaaa attctcaaaa acactttcac   1140
 ctaacaattt catttttaga gcggtatctt ctggaaataa gtcattttct atggatgtga   1200
 ttaagatgtt aatcatatca ctatttacag attacattat aatacataat caaattgctg   1260
 aataggaaat aaatcttaaa gttatggtat acccatgaaa taaaatatcc tacagctgtc   1320
 taaaaagcaa aatatttaat atgggaacat attgacaata tatagagcag actacaaagc   1380
 aatgtacatt atgatttcat ttttgagaat ataaatgcat aactatgcat agaaaaataa   1440
 gcaaaaacac aacatcaaaa tgttaacaga gtttatctcc ctagatggca ggattacagg   1500
 gaactgtgtg tccaggcaca tgaactcttc catatcatcc agcttccaga aataacatca   1560
 aatttttacg ctgtgaaatc atttactatt cgttttaagg aactaaaact aatgaggaat   1620
 cttagggtca gtatactttt cacatttgct tgaggggggg taaggaatga aaggcaataa   1680
 ttacacctgg aagcaaatgt gaacagtctt tttcgaaagg aaaaagttgt atttaattaa   1740
 gtcccggtaa aacatcacct tagcatttga agttgttcta attaatattt tattcttcaa   1800
 cacttttaaa gactccaata tattagacaa agaatttttt gataatgtaa gttaatttct   1860
 ctggagacaa ccatataatc ctctaaaatg acatgaacgt ttatatatgg gactgaagct   1920
 tctgcagtct atatatacct atttgggggg aaaaaagtaa agtactgaca attcaatttt   1980
 aacaaaaaaa aaatgctttc cttatcaaac attaatgttg tgtacatgaa cctatcatct   2040
 gtgacagcaa ggaactcaag ccaggtgatg cacaagcctt cacccagctc agttagcttg   2100
 ggcttctcct gtaccagatt tgcctgaagt aacatgaggt tatttaaaaa gacctccacc   2160
 tagattgcag tgagccgaga tccctgccac tgcactccag cctgggcgac agagcaagac   2220
 tccatctcaa aaaaaaacac aaaaccaaac aaacaaacca acaaaaaaaa cctccacttt   2280
 ccagcatcta ctcaaaaggg aagtccttcc ctaatccaga agagagataa cgttccttcc   2340
 ctaagggaag acagaaaaag gagaagagca tttgttaagc attctcccat acatgtcttc   2400
 cctaggtatt tcacatccaa tgtctcaata accccatgca aacatgcata caattcttta   2460
 gactgctccc ttcattaccc aaaaaagaag ggaactatgt cttcctaatt gattttaggt   2520
 gcctggaaca actaagtatt tcactgaaag acatgtaata aatgctattt gataggtaaa   2580
 aaaaaggaaa aaagcaaagt tacctctttt catttggctt aaagaaaaaa aaagtatgtt   2640
 ctactatata ctaaaatatc agaccaatac acaatatatt gcaaaatttt aataccatgt   2700
 ggttaaacac aatattcaaa tattaaactt ttcaagcaca tgaaagtcac cttctgaaag   2760
 acaaactggg ctttttttat aactaccttt gtgtaacttt ataaaattac ttccctcaac   2820
 aatatctgac actgatcttg atactagtta gaaagtctga tgtaagatga tgacatctca   2880
 acgtcagtga tttaggagat tatcttcaga attcatcaga ggaccaatcg tcatcttcat   2940
 cccttacttc tcggtatctc cctgaagact ccccttctgg attataactc cgcattttaa   3000
 tattcagtct ttcagctaat ttttgcgctg cgagctttgc ttgcatctcc tcataattct   3060
 gtttctgctg tttctgaagt gccaaggatt cttctatgga gagcagctgc gtgggcatat   3120
 ggtgaagtgg tagaagccga gctgctgtga tgtcatcaag atgctgctta tccctgcgcc   3180
 gccgctcttc tgaggaaata ggagacccac tcttctggca atgactagat gaatcatttt   3240
 gtcgaaaagg taacacattg gttttaaatt tacgcagctg gggcactggg tttttggctc   3300
 gcatttctag cacttccatg taatgaggtt tcttctcagt cccactggaa aggcctgtca   3360
 agttcttagt acttgcgttt tcttctgact gttgttcacc ttggtccgca atggtgatcc   3420
 tctgtaacct gtcaataaac aggttgtcaa agctgctgga agtatcttcc gcttgacttg   3480
 aaacacgatg ccgcgggtga tgctcactag cttcagatga aggtggtacc ctgtctctat   3540
 tgctggaagc tgggccctta ttcactgtgt actcaacctc tgaagtctct tcatcacctt   3600
 caagagtagg acgtccaagt ccctggtttt gtgaggtttg agatgacttg atgttatcta   3660
 cagaggaaca tccaggaact agtgatgaag tatcaagtat cgggtcagaa ttctgggcct   3720
 tatctgtacc cacatcaact tctgcaattg ctttttgcct tagcttacag tctaaactaa   3780
 cagggttaaa cagttcactt tttcttctaa cttcttcaca ttctgcc                 3827



      <210> 364
      <211> 588
      <212> DNA
      <213> Homo sapiens


      <400> 364
 tttttttttt ttggggctgg gtaccaataa aactttattt atagacactg gaattcgaat     60
 ctcatatcat tttcatgagt cacagaatct tcttcttttg ctatttaaaa gcaaaaataa    120
 aaattcttgg ctgggcacgg tggcttgtgc ctgtaatccc tgcactttgg gaggctgaag    180
 tgggaagatc atttgaggcc aggagttcaa gaacagcctg ggccacctat gggggatccc    240
 ttttctacaa aaaataaaaa atgaaataaa ataaaattct tagttcatgg tcaaaaacag    300
 gatttgcttt gcggaacacc atttgcagtc ccctatgcta acctatctag gtgcttaaaa    360
 cagtacctaa caccctgttc ttgggttggc tttaaacacc aaccaaggat ttaatacctg    420
 ttagccattt caggtggaaa gatgtgaatg tggtatgaag tgggtcatct gtggcagttg    480
 gcttgttggt gagggacagg ccattggtaa tggaagggtc agctctgtct tggaacagct    540
 gcccagagca tggcccgcca tgctccccct caacacccaa agtgacac                 588



      <210> 365
      <211> 1209
      <212> DNA
      <213> Homo sapiens


      <400> 365
 ctttattgaa tattgacacg gaagaggctc cacacacaaa aactctttat aagttctcat     60
 atattttgat gatcatgttc gtggtagata tgaatattgt gttaaatgta agaaaagtgg    120
 cttttgttct ggaatattac tttggtcagt taggaatcag atctgccaca cataaagggc    180
 aggttcataa aggctgtaca attccactgt cctacatcag gcaaggaggg taaaataact    240
 cttcaggcct ttattcaccc aaattgaatg tgtttcataa gaaattctac tcagagagaa    300
 agtctgcata ctgagaaaat tatatagcaa tcatgttttc ctaacccaaa aataaaacaa    360
 caagatggaa aagttcacag cactttatgc cccacacgct cccctacgac catctggaga    420
 caagactgaa ctgggaggag ggactgtgga ctctctgagg gctcaatatc aagagtctgt    480
 gcaataactt cgagatcctt ctttgattag ctgtgttttc tcatttgcat ttgtaggctg    540
 gagaaaaact ggaaagtcca catctttttc catgtcagac ttgatctgct cctccagatc    600
 ctctggggac acatagaagt cctcttctgg cactgatgac tcgggccggc agtgtccaca    660
 gcagcagttg cagcagcagc acaggcagca gcaaaagtag cagcccgtca agaggccaac    720
 gatgacaaac agggcctttg cacaccagct cgacagcatg aagtaggtgt taacgttttc    780
 gtctccaaac tgctcggcca cgtagagtcc cagcgatccg tacttgtcgt atatgcttct    840
 ctttgaaatg tcggtaagta ttgcgtgggc gtctgtgatt tctttaaact tctcagtagc    900
 agctggatca tctggattct tgtctggatg gtgtttcagg gccaattttc tgtaggtttt    960
 cttaatttct tcatttgatg ctcccttatg cagaccaaga atttcgtata gagcttctcc   1020
 tgttgttgac agagtccgct gtctttggtt aggtatgtta catgccattt tctaaggctg   1080
 caaaactgtt ccaccgtttc aaagcaaaca gctgctcctt tccatccttc ccccccatgc   1140
 agggttaagc aggtcaatag agtcaggtta cttttcattt gttactttgc cagccaattg   1200
 gttatccct                                                           1209



      <210> 366
      <211> 2644
      <212> DNA
      <213> Homo sapiens


      <400> 366
 aggcttgcgg ccgcgggagc tgaccctgcg gggtcccggg gggggagggg gagccgcgaa     60
 gcccccactg aggccgcgcg gtgccgggcc tcccctcccc cccgggcggg cgccatgcgg    120
 gggagcccgg gcgacgcgga gcggcggcag cgctggggtc gcctgttcga ggagctggac    180
 agtaacaagg atggccgcgt ggacgtgcac gagttgcgcc aggggctggc caggctgggc    240
 gggggcaacc cagaccccgg cgcccaacag ggtatctcct ctgagggtga tgctgaccca    300
 gatggcgggc tcgacctgga ggaattttcc cgctatctgc aggagcggga acagcgtctg    360
 ctgctcatgt ttcacagtct tgaccggaac caggatggtc acattgatgt ctctgagatc    420
 caacagagtt tccgagctct gggcatttcc atctcgctgg agcaggctga gaaaattttg    480
 cacagcatgg accgagacgg cacaatgacc attgactggc aagaatggcg cgaccacttc    540
 ctgttgcatt cgctggaaaa tgtggaggac gtgctgtatt tctggaagca ttccacggtc    600
 ctggacattg gcgagtgcct gacagtgccg gacgagttct caaagcaaga gaagctgacg    660
 ggcatgtggt ggaaacagct ggtggccggc gcagtggcag gtgccgtgtc acggacaggc    720
 acggcccctc tggaccgcct caaggtcttc atgcaggtcc atgcctcaaa gaccaaccgg    780
 ctgaacatcc ttggggggct tcgaagcatg gtccttgagg gaggcatccg ctccctgtgg    840
 cgcggcaatg gtattaatgt actcaagatt gcccccgagt cagctatcaa gttcatggcc    900
 tatgaacaga tcaagagggc catcctgggg cagcaggaga cactgcatgt gcaggagcgc    960
 ttcgtggctg gctccctggc tggtgccaca gcccaaacca tcatttaccc tatggaggtg   1020
 ctgaagacgc ggctgacctt gcgccggacg ggccagtata aggggctgct ggactgcgcc   1080
 aggcgtatcc tggagaggga ggggccccgt gccttctacc gcggctacct ccccaacgtg   1140
 ctgggcatca tcccctatgc gggcatcgac ctggccgtct acgagactct gaagaactgg   1200
 tggcttcagc agtacagcca cgactcggca gacccaggca tcctcgtgct cctggcctgc   1260
 ggtaccatat ccagcacctg cggccagata gccagttacc cgctggccct ggtccggacc   1320
 cgcatgcagg cacaagcctc catcgagggt ggcccccagc tgtccatgct gggtctgcta   1380
 cgtcacatcc tgtcccagga gggcatgcgg ggcctctacc gggggatcgc ccccaacttc   1440
 atgaaggtta ttccagctgt gagcatctcc tatgtggtct acgagaacat gaagcaggcc   1500
 ttgggggtca cgtccagatc cttctgctga ctgccagatc cctgcatttc aagcactacg   1560
 ccttccaccc ccaggcactg gatcccagat tcccaagcct tcacccacca gattctggct   1620
 cctaaaacaa gtgcgggggc cccagtggca cagcaagtgg atcctggcaa ctgcagctgc   1680
 tggattccag attctgggtc cccaatccct ctgcccagtc cctcaatgtt gaaacctcat   1740
 ctcttgaagg cagatcctga tattccaagg cactgaatcc caagccctga atccccggtt   1800
 tctgatctga atcttccagg cgccgggtcc caaatgttca ggccccaagt ctagatcctg   1860
 gcagcccagt cacagagtat cccacacaca ctggtgccca gagccggctt ctcatgacat   1920
 gaaattgcat ggtcgaggga gtctgtgggg aaggaagccc aggtcctggc tgcaacctgc   1980
 acggatgctg gattccccct caccccacct ctgcatggcc accccctccc agccctgtgg   2040
 ggaaactgtt ccctggaacc actccactcc ctgcatcccc acacttcaca gcatcttcca   2100
 tccccctccc accttctagg cgaatagtcc ccagagctgt gttcctccaa ggggtccgag   2160
 gaatcactca ctcctggagg ctggcaagga gacagtctga ggccagggac acatgaaggg   2220
 atgtccccac cccagcacta tcagggcctc cccaggcttc cagagttgaa agccaggaga   2280
 aaatcggcaa agaccaccct tccctaaacc caagcacccc aatgatgcaa aaaacaaaaa   2340
 caaaaaaaaa cccacccaaa tcccccaaat tcattccaga tctatttttc taccagagag   2400
 aggagcaaag tcctcctccc ctgcgccctt acattctgca cttcatagtt ggattctgag   2460
 cttaggatca tctggagacc ccatggaggg acttggaaag gggaactggg atttggggag   2520
 gggctggagg acttccgcac gcttccacct ccttcgacct ccactgcgcc ccacctccct   2580
 gcctgtgtgt gttatttcaa aggaaaagaa caaaaggaat aaattttcta agctcttaaa   2640
 aaaa                                                                2644



      <210> 367
      <211> 1852
      <212> DNA
      <213> Homo sapiens


      <400> 367
 ttttttttta tgtttttttt aactgtttat actggtttaa tccatgtcaa atgtagttta     60
 caaagggaaa ggacaagtac ctttgtatag aatatacaga cacagcatca caccataggg    120
 cccacgggag ggtcggggag acgacacttt ttccctggga aaggcagctc taatcccagg    180
 aatggttctc agcagaggct gggtggccag gagcactgtc ctctagcccc ctaactcagc    240
 ctctgcttca gctcggttcc catttcctgc ctctaccccc caactcctta taaagagccc    300
 catgagctaa gactaaggag aggatcatgt cccttggggc gtgtgcccca tgtctgggag    360
 aagaaatata caccactgaa caccgagcac atgggagagg gaagggacac cacaggagag    420
 agagaggcag gtaccccaag aggtggatgg gccgagctcc cagccaaccc tgaaggaggc    480
 gctgcttcca ggggttctta aaaaagaaga aaatcataca accaaagggg gaggggacag    540
 gtagagggcg aggagttgtc ccatttatac acaacattgt aaacatacac ggtctatatt    600
 acatgtgctt cagtctggtg tttgcatgtc tgtctgtccg tctgtcagta tgggggctgg    660
 atcttaggag ccgtgcccca ctactccccc aacccccacc tccctgcccc accctgggaa    720
 cagagctgga acaggtatgg cccccaaacc ataggtggga gccagcaggt agtgcctggg    780
 ccacagcctc tactctggct ccagagtcct gcgtgtgtaa atgtgtgtgt gtgtacgcat    840
 gtttgagtat gtgcatgtat gtacatgggg aacctgtgtg caagtatgta caaagggaga    900
 cggtcactgt cacagaggct gggggcaggt ggggctgctg gaggcgaggc ctgcctgggg    960
 cagatagctc acaagtagat cctccgcagg tctccgggcg ctgtgatcgt gttgcactga   1020
 gggcagagct tcttggcacc cagggtccgc agccagcact cctcgcagtg cacgtgccaa   1080
 cactggatgg acgttagggg catcgagtac gagtccatgc agatgaggca tttgtaacgg   1140
 tccccacgag atagctgccg ttcaagttct ctgacccgag ccttcagagc ctcaaacgtg   1200
 gtcacagctg aatcttcggt gattttctcg atgtcgctgt tcttgcaggt cttctgcatg   1260
 gcctcctgct tgctgctttc accattgctg gtggatggca tctcatcact ggcccattta   1320
 gagaactcag gtgtgatgcg cgtgctggga gggccgccat ttaggactgc gccccgaagt   1380
 gcctctctct ccttggcttc accaggctcc tcgcctgtgc aggggatgac atcagcctct   1440
 gtgtattgtg gcttcccata ctccagagtg tcatccccat ccacatccaa gtcagcatca   1500
 ctgtccgggt tctctttgcc gctgcacatg atgaagccag agcctcggaa gccaccttcc   1560
 aggagagtgg tggcccgtat ccgcttctgt ccacaccact catactcctc aaagcggttg   1620
 ttgttctcat gctcgatgtc cacagcatca tcctcagcca tgcaggagcc ttccctctgc   1680
 ccttcatctt gcttcctccg tttcattttc ccaatccgag cattcagtcg ggtctgccgg   1740
 ttggctcgta ctcgcagaaa ggtctacttc ctccctcccg ccggcccctc tgctcctccg   1800
 gccgctccgg gctctcggca tagccgccgg gcgctgctct aacgggacga aa           1852



      <210> 368
      <211> 2338
      <212> DNA
      <213> Homo sapiens


      <400> 368
 tttcgtgttg cagcccaggc ggaggcgcgg gatctcgagc tgggatcgcc ctcttgggct     60
 tcggtgcgat cggcggcggg aggttccctg ggaaccaggt ggtcgaaggg ctgagctgtg    120
 tggccagaca agaggtccct gccctccccc agtgagccct gctgttcccg tgggagccat    180
 gaagctgaac gagaggagtg tagcccacta tgcactcagc gactccccag cggaccacat    240
 gggcttcctg cgcacctggg ggggcccagg gaccccaccg acccccagtg gcactggccg    300
 aagatgctgg tttgtcctca agggcaacct gctattctcc tttgagagtc gcgagggccg    360
 ggccccactg agcctggtgg tgctggaagg ctgcacagtg gaactggccg aggctcccgt    420
 gcccgaggag tttgcctttg ccatctgctt tgatgcccct ggagtgcgcc cacacctgct    480
 ggccgcagaa gggccggcgg cccaggaggc ctgggtgaag gtgctgtccc gggcaagctt    540
 tggctacatg cgcctggtgg tacgcgagtt ggagagccag ttgcaggacg cacgccagag    600
 cctggctttg caacgccgct catcctggaa gtctgttgcc agccgctgta agccccaggc    660
 tcctaaccac cgagctgcgg gcctggagaa tggccactgc ctctccaagg acagcagccc    720
 tgtgggcttg gttgaagaag ggggcagcag gtctgcaggg tgggggttgg ctgagtggga    780
 gctgcagggc cctgccagcc tcctcctagg caaggggcag agccctgtgt cccctgagac    840
 ctcctgcttc tctaccctgc atgactggta tggccaggag atcgtggagc tgcggcagtg    900
 ttggcagaag agggcccagg ggagccactc aaaatgtgag gaacaggata ggccctaagt    960
 ctgggccctt tgagtcagga aaccagggcc agttcttttt caggagttaa atgtttacgc   1020
 atttccaagg ttgcgttttg ggaggggaca tgggttctct ccttcctgct atttaggcat   1080
 tctccaggtt cgagatccac ccgtgtgtct ggaagggact gcgggaccat tccttccatc   1140
 ctctttattt cctgaggtcc agagaaggaa ggagacttag cagccacaga gcaagacccc   1200
 aatctcctga ctgcactggc ctgactgccc cctcccaggg gatgttaatg aaatgaagga   1260
 agtggggaat gtcacccgag actgtcacag gcttgccata cctttggcct acacaccggg   1320
 ctctagagcc ataatttcca acctggggag tctcctgtgc acttaaatcc gaggtaggct   1380
 gcagtatcgg cttgaagctc tgacactgtc agagaaagtg gatttattgt gtcataggag   1440
 tttctgggac ccagctcttc ctgagagggg tgggaagatt ggggatggga tcctcactca   1500
 gcagtctggg tagggccctt tgaggcagag ggtcttcggc cagtgaagag agatttattc   1560
 tgcttctgct cagagtgctg gggtcccatc ctttctccct ggctgccctg ttaacagatg   1620
 gtgctggacc ttgccccgga aggggcttgt agctttttta cgtcaacgaa atgccctcct   1680
 gtactctgtc ttcagcagcc aactcctgga gctgccaagt gaggggttaa agaagaggtg   1740
 gggaggcagt gtggctccct gggaaaagtc tgttgctttg gttctcagtc ctgggtattc   1800
 taggagcttg gacacgggat tgcgtttcct gtgctaaaat tctctctcct ggctgggctc   1860
 cggtaaactg aagctgctcg agaaatcacc tgggaactct catagccgtt tgtcacccag   1920
 ggtgtacttg ccaggacctc tccttgctac tcttcccaaa gtcgggaggc aaagcggctg   1980
 ggtcaccaga gcctgaccat actgacgctc cagggggaag acgcagaggc cgggaagaga   2040
 caccccctcc caaacacata aaacttgccc cttcctagcc tcggctcccc tcactggggc   2100
 cttgggcagg accgacccgc atccaactag gcctaagggg taggctctga gcctcttacc   2160
 cctaagaggc ggagatgcgc ccaaggcggg cgcccggcct gttccccagc cctgcctgga   2220
 agccccgcag ccactgcatt ttgtttaaac acagatagca cgggcctttc tcttattgct   2280
 acagtgtttt gtacacggtt aaaacactag taaagctttt tcgttattaa aaaaaaaa     2338



      <210> 369
      <211> 466
      <212> DNA
      <213> Homo sapiens


      <400> 369
 atgctagcca ttttcaaata tctcatcaac aaccgactaa tcaccactta acaatgactg     60
 aaaaactaac ctcataacaa atgataacca tacacaacac taaaggacta acctgatctc    120
 ttatactatt atccttaatc atttttattg ccacaactaa cctcctcgga ctcctgcctt    180
 actcatttac accaaccacc caactatcta taaacctatc catggccatc cccttatgaa    240
 cggtcgcaga gtttataggc tttcgctcta agattaaaaa tgccctatcc cacttcttac    300
 cacaaggcac acctacaccc cttatcccca tactagttat tatcgaaacc attagcctac    360
 tcattcaacc catactcctg gacgtactcc taaccgctaa cattactgca ggccacctac    420
 ttattcacct aaattgaagc ccactctacc aaattaacca taacct                   466



      <210> 370
      <211> 577
      <212> DNA
      <213> Homo sapiens


      <400> 370
 gaaataaaat gattaaatat aaataaaaaa tataattata ttaaaagata agattattat     60
 aaaattataa tataataaaa aaatgaatat tatataaata aataagtaat ataataaaga    120
 ataatataaa taaaatatga aaaaaataat aaaataatta aatatattat agccaagtgt    180
 caactccaac tattgtaaag gtctcaagaa acctaggaaa agtgggcagc aaatgttgta    240
 aacatcctga agcaaaaaga atgccctgtg cagaagacta tctatacgtg gtcctgaacc    300
 agttatgagt gttgcatgag aaaacgccag taaatgacag agtcaccaaa tgctgaaaag    360
 aatccttggt gaacaggcga ccatgctttt caactctaga agtcgataaa acatacgtta    420
 ccaaaaagtt taatgctgaa acattcacct tccatgcaga tatatgcaca ctttctgaga    480
 aggagagaca aatcaagaaa caaactgcac ttgatgagct cgtgaaacac aagcccaagg    540
 caacaaaaga gcaactgaaa gctgttatgg atgattt                             577



      <210> 371
      <211> 298
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(298)
      <223> n = a,t,c or g


      <400> 371
 gcacgagccg acatgctgcg tgatggtgtg gcttcctcgc ccctctctgg ggtgggtgtg     60
 ggggtggagt ggccttnccc acgcctctca cctctgcctt catttgtgct gccaccctgc    120
 ccctccctcg tcctcctctc ccacttcctc ctctctgtgt gcctcagtct cctgccggaa    180
 gaaatgggtt gagcccgaaa ggaggctgtc tgaggaaggg agagggaggg cctggggtnn    240
 ntnnnnnnnn nnnnnnnnnn nnnnantntn tnntnnntnn tttttttttt tttatttt      298



      <210> 372
      <211> 393
      <212> DNA
      <213> Homo sapiens


      <400> 372
 aatacagggt ctctctccac aatgagttat ttgatgctga acaagagtga tgtggcctct     60
 gaaggttctc ccacattcac tatatttaca aggttttttt ttttccatca tactttcttt    120
 gtataattaa atctgagttt tgtttgagca tctttcaaca tgtaccatat ttatgacaat    180
 tctcttccat aggatctatc tgttctgcaa caagtattga tcttacagta aaatttttca    240
 caaattcatt aaattctatg tctctttttc tggaaggaat ttttgtgcag gtagctatct    300
 cttgccctaa attattctcc ttgtttagct gctgattctt aaactggcct ctagatttcc    360
 agatttcttc cggtacagac tttctctttg cag                                 393



      <210> 373
      <211> 391
      <212> DNA
      <213> Homo sapiens


      <400> 373
 ttggattcag tttgatagca ttttgttgag gacttttgca tctctgttca tcagagatat     60
 tggtctgtgg tttacttctt ttgttatgtc ctttcctggc tttggtatca aggcgatact    120
 ggtttcacgg aatgagttag agagaatttc ctctttttca atcttttgga atagattcag    180
 taggattggt tccaattctt ctttggatgt ctggttaatt cagttgttaa tccacctggt    240
 tctgggctat ttttttttct tttggaggca attttatttt tattatttta ttttatttta    300
 tttttattaa tttttttatt tttattttat tattatcatt tttttgagat ggagtctcac    360
 tctgtcaccc aggctggaat gcagtggcat g                                   391



      <210> 374
      <211> 424
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(424)
      <223> n = a,t,c or g


      <400> 374
 cccacgttca gtgaggcagg tattattgta cctgttttat ggatagggaa actgaggcta     60
 gactctaaat tactactctg aggcacatct tttttttttt tttttttttt gagaaaaggg    120
 ggtttttttt ttcccccggg ggggggggaa aaaaattttt ttggtttaaa aaaacccttc    180
 ttttgggggg ggagggtttt tccccccccc cctcttaaaa aaaaaaaaaa aaaaaaaaaa    240
 aaaaaaaaaa aaaaaaaana gggggggggg gccttaaaaa aaaaaaaaaa taaaccccgg    300
 gggggggggg aaattttttt ttttttgggg ggccaaaaaa attttttggg ggggggggtt    360
 taaaaaaacg ggggggggaa aaaacccggg ccccccaaaa taaaaagggg gtttcccagn    420
 nnnn                                                                 424



      <210> 375
      <211> 414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(414)
      <223> n = a,t,c or g


      <400> 375
 gttcgctttt atcctccaga gccgncgcat acacttcttc tccagtgtct cagtgccgtt     60
 gctttctccc aaccctgtcc ccacccctcc aggctttgaa cccttgctgt gcatcaggcc    120
 ccccatgttc ttcttgagct tgctgcccaa ggttttgcca aagctgccca gtttgttagc    180
 cacagaatct gctctcttct tgtccttctc ccgatctcgc tttgacttct ccttccgccg    240
 gccgccctcg ttgctggtgg aactgctgcc aactgactcc ttgtctgagt ctccagactc    300
 aggagtggac cggggctcat ctccagctga ggcggtgggg gactcaggct gggccagagg    360
 agcctgtgca tcagaggaca gtgggatcca cttcacattc atgtagctat gcag          414



      <210> 376
      <211> 417
      <212> DNA
      <213> Homo sapiens


      <400> 376
 aatacattgc ccatagcttt ctgctttgtg gtgaaaggcc ggcgatctga tgccacgatg     60
 ttcagagtgt cattggccag caggctcatg aggtaggttg aggtgttggt gtccactctc    120
 acgggaggca ccgtgacata agcagccgcg tgggaccagt cctggcggta gtagtgtaat    180
 cctgtttccg tggcatagtg cagcggtggg ttccgccagc acaacctttc cttgcatctt    240
 accagctgtg ataacgtcac cagccgacat actggacacc gttgaccagg gagactggac    300
 agtgagtcct gtctcgattg gctatacccc catgagtgtg atatgtgagt tacctctctt    360
 gtaccgctga ttcgctcccc tcttcccctg tgattctcga cctcgcgctc catcgcc       417



      <210> 377
      <211> 551
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(551)
      <223> n = a,t,c or g


      <400> 377
 tcgcactgag tttatngaga gtcccgccca cagcctggca ttcctgggtg tctgttcccc     60
 tggctgctcc ccatcacctt ctctcaccct gggccctgtt tttgttccct gcctcatgcc    120
 tgactgatca tcttgccctt ctgccaacat aacttatctt gccagctagg ccgggagctc    180
 cctgcagcct ggaactgtga ggctgtcttg tttcgcttgg cgtttcccat gcctggcaga    240
 gggtaggcac ttgggaaata tttgtagggt aaatgaatgc gggatgaatg agtgcgtgaa    300
 cgagaggaac agaaatttcg cgcattggcc aatggatggg tggggaagga atgtctgggc    360
 tcacctcctg gttcctcctt ggagagatga acccctgagg gctcagggag cttaacttgc    420
 ttcttaccct cagcatcacc atgaacggag agaccatcgc ctgtgctgag ggctgccagg    480
 ccatttgtga caccggcacc tctctgctga ccggccaacc agccccattg cccaacatca    540
 gagcgacatt g                                                         551



      <210> 378
      <211> 527
      <212> DNA
      <213> Homo sapiens


      <400> 378
 cttctggata actgtcaaat gacagttctt ggagcaccta cctgtatcca tggaaatact     60
 gtctctgtga tctgcacagg aagcctgacc cagccactgt ttccatgcct cgcaaatgta    120
 tctgacccat atttgtctgc agttccagag ggcagtgctt tgatctgctt agaggacaaa    180
 cggctccgcc tagtggatgg ggacagccgc tgtgccggga gagtagagat ctatcacgac    240
 ggcttctggg gcaccatctg tgatgacggc tgggacctga gcgatgccca cgtggtgtgt    300
 caaaagctga gctgtggagt ggccttcaat gccacggtct ctgctcactt tggggaggtg    360
 cagggcccat ctggctgatg acctgactgc acaggaatgg agtcccactt gaggcaggcc    420
 ctttcggagc tgtggcctca atgatggatg ccaatggaga cgctgggtca tgtgtcaaat    480
 ttcatctctt aggcttactg ggaactatat aaaagctatt tcgagcc                  527



      <210> 379
      <211> 402
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(402)
      <223> n = a,t,c or g


      <400> 379
 gagactctgg aaatcctttt gcattaaaag gactttacac acctgtgtaa aaggatgtgg     60
 gagaggaggg tctgaagctg agctgctaaa tgaatatccc tgctctgctg gtcaataaaa    120
 cgcttcctaa tagcanaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    180
 aaaaaaaaaa aaaaannnnn nnannnnnaa aaaannnaaa aannnnnnnn nnnncccaan    240
 aaaaaaaaaa aaaaaanaan aanaaanana aaananaaaa aaaaaaaaaa aaaaaaanaa    300
 annaaaaaaa naaaaaaaaa aaaaatttaa accccnaacc ccnaannana aaaaaaaaaa    360
 aaaaaaaaan nnnnnnnnnn nnnnnnnnnn aaannaannn an                       402



      <210> 380
      <211> 338
      <212> DNA
      <213> Homo sapiens


      <400> 380
 cttaaatcag tatttcagta ggaaaaattc ttagaaatta aactgtgagg gcaagcaatt     60
 gtgaacattt acattttaat aagtaccaac aaattacctt aaaacgtgta ccgatggata    120
 ctcttagtaa aatgtaagag agtgattcac tacattctta ctagctcagg cattatcaat    180
 ttttttttat tttaaattac tgcctaagaa atacagtcat atatcttgtt cttttatttt    240
 aaatttctat ttgagaagtt atgcactttt gtttgtttgt tttttgagac agagtcttac    300
 tctgtcatcc aggctggagt gcagtggcac aatctcag                            338



      <210> 381
      <211> 423
      <212> DNA
      <213> Homo sapiens


      <400> 381
 agtatttagc catattagca tatctttaga ggaggcctgg tggaataccc ggggcctcta     60
 ctagtctgtt tttccggtca taggaagact ttttttttta cgtatcaaag tatgcgtgaa    120
 cagccccaaa aaaaaaaaaa gggggcgccc ccctaggagg ccccccgagg ggccccatct    180
 taccgcggat acccgagaac agacgtcccc cctaataggg ggccctttta aagcccagcc    240
 ccggcccgcg gtttaacacc gcctggccgg gaaaacctgc tccccgggaa tctttgaaaa    300
 gagccccttc cttggggggg ggcccaaagc ggcccaaccc cccaccggag gttaaagcct    360
 ctggggcaga taaaaaattg tagggggata aaggggcaaa ccaagctcca tcgcccgcgg    420
 gcg                                                                  423



      <210> 382
      <211> 365
      <212> DNA
      <213> Homo sapiens


      <400> 382
 gctatcatat agtgcaaccc agtccatgac ccctagcagg ggccctctca gccctcctaa     60
 tgacctccgg actagccatg agatctcact tccactccat aacgctcctc atactaggcc    120
 tactatccag cacactaacc atataccaat gatggcgcga tgtaacacga gaaagcacat    180
 accagggcca ccacacacca cctgtccgaa aaggccttcg atacgggata atcctattta    240
 ttacctcaga agttattttc ttcgcaggat tattctgagc cttttaccac tccagcctag    300
 cccctacccc ccaattagga gggcactggc ccccaacagg catcaccccg ctaaataccc    360
 tagaa                                                                365



      <210> 383
      <211> 125
      <212> DNA
      <213> Homo sapiens


      <400> 383
 cttatgaatt cgaacagcat acccccgatt ccgctacgac caactcatac acctcctatg     60
 aaaaaacttc ctaccactca ccctagcatt acttatatga catgtaaaaa aaaaaaaaaa    120
 aaagg                                                                125



      <210> 384
      <211> 371
      <212> DNA
      <213> Homo sapiens


      <400> 384
 cccacgcgtc cgaaaaaaaa gaaagaaaat attttaaagg tcagaagcta caagcttttc     60
 atcatttagc caagactcca tctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    120
 aaaaaaaaaa aaaaaaaagg gggggggggc aaaaaaaaaa aaccgggggg gggcaaaaaa    180
 aagggggggg gggaaaaaaa aatttttttt tttaaggggg ggggaaaaaa aaaccccggg    240
 ggggatttgg gaaaaaaaac ccttttgggg ggggggggaa tgggggcccc ccccccccaa    300
 aaaaaaaaag gggggggggg aaaaaaaaaa attttggggg gggggggggg gaaaaccccc    360
 cgcaagcggg g                                                         371



      <210> 385
      <211> 531
      <212> DNA
      <213> Homo sapiens


      <400> 385
 tttcgtggca gctgaggtga gagacggcgg cggcggcgcg ggcacccggc cccccagcgg     60
 gaggatgaag cggcggaacg ccgactgcag taagctccgc cgccccctaa agcggaaccg    120
 gatcaccgag ggcatttacg gcagtacatt tttatacctg aaattcctgg tggtgtgggc    180
 acttgtcctc ctagcagatt ttgtcctgga gttcagattt gaatacctgt ggccattctg    240
 gcttttcatc agaagcgtct atgattcctt cagataccag ggactggtat gtctggtaat    300
 acatgttttc catgtgtggg gaccattcag ctgtttagag tagatgttat tagcaatact    360
 caggtaacta tgttaggatt agctaatagg gtctgttaac tgaaattgac ctctaaacta    420
 ttttgtctaa acccattgat caaatagtta cattttctcc tcctctccca ttccagtgaa    480
 acagaacagt ggaggaagca ataattactc aggcttttgg agggctgtat t             531



      <210> 386
      <211> 459
      <212> DNA
      <213> Homo sapiens


      <400> 386
 gaagctgatc cttaagcggc gcatacaggc taggttaagt actgaatcat tcctacatga     60
 ttcctggcag gagaaacgtg acaaggtgca tctcaagaca actagaagtg caacctcacg    120
 ccttggaatt gccggataaa tgttccttgg cctttgttgt acgcatcaaa aggattgatg    180
 gcgggagttt actggtgcag agaaccattg caagactttg cctgaagaaa atttttagtg    240
 gtgtcttttt aaaaatgctg cgtatagtgg aaccttatgt gacctgagga tttccaaatc    300
 tgaagtctgt ctgggaattc attttgaaac atggacaagc caaggtcaag aataagacca    360
 tcggccagac gcagtggctc acgcctgtaa tcccagcact ttgggaggcc aaagatgggt    420
 ggatcatgag gtcaggagat cgagaccatc ctggccaac                           459



      <210> 387
      <211> 456
      <212> DNA
      <213> Homo sapiens


      <400> 387
 ggaagtgcga agccatgtga aggtgctggg ggagatgcta gtcatgtacc gcaggccagg     60
 gcaggccccg cccgaccagg aggccctgca ggtcgtgtat gagaggtgtg aaaagctgcg    120
 gcccacgctg ttccggttgg cgagtgacac cactgatgac gatgatgcac tctcggaaat    180
 tctccaggca aatgacctcc tcacccaagg agttctgctg tacaaacagg tgatggaggg    240
 ccgggtcacc tttggaaaca gagtgaccag ctcattggga gacatccctg tctccagagt    300
 ctttcagaat ccagcaggct gcatgaagac ctgccccctg attgacttgg aggtggacaa    360
 tggacctgcg cagatgggga ctgtggtgcc atctttgctt catcaggacc tggcagcctt    420
 gggaaatagt gatgctcctg ttacaggcat ggtttt                              456



      <210> 388
      <211> 1091
      <212> DNA
      <213> Homo sapiens


      <400> 388
 cggacgcgtg ggcggacgcg tgggcgcgcg ccggaagtac ctacctggga taacggcggc     60
 gagcggacgg ctgcatttac ggggtctccc ggagggccag agtcgtggct tacagaagag    120
 acgaaatgtg gtctgaggga cgatatgaat atgaaagaat tccgagagaa cgagcacctc    180
 ctcgaagtca tcccagtgat gaatctggtt atagatggac aagagacgat cattctgcaa    240
 gcaggcaacc tgaatacagg gacatgagag atggctttag aagaaaaagt ttctactctt    300
 cccattatgc gagagagcgg tctccttata aaagggacaa tacttttttc agagaatcac    360
 ctgttggccg aaaggattct ccacacagca gatctggttc cagtgtcagt agcagaagct    420
 actctccaga aaggagcaaa tcatactctt tccatcagtc tcaacataga aagtccgtgc    480
 gtcctggtgc ctcctacaaa cggcagaatg aaggaaatcc tgaaagagat aaagagaggc    540
 ctgtccagtc tttgaaaaca tcaagagata cttcaccctc aagtggttca gcagtttctt    600
 catcaaaggt gttagacaaa cccagtaggc taactgaaaa ggaacttgct gaggctgcaa    660
 gcaagtgggc tgctgaaaag ctagagaaat cagatgaaag taacttgcct gaaatttctg    720
 agtatgaggc gggatccaca gcaccattgt ttactgacca gccagaggaa cctgagtcaa    780
 acacaacaca tgggatagaa ttatttgaag atagtcagct aaccactcgc tctaaagcaa    840
 tagcatcaaa aaccaaagag attgaacagg tttaccgaca agactgtgaa actttcggga    900
 tggtggtgaa aatgctgatt gaaaaagatc cttcattaga aaagtctata cagtttgcat    960
 tgaggcagaa tttacatgaa ataggtgagc ggtgtgttga agaactcaag catttcattg   1020
 cagagtatga tacttccact caagattttg gagagccttt ttagattttt ctgctcaggc   1080
 taaaaaaaaa a                                                        1091



      <210> 389
      <211> 1887
      <212> DNA
      <213> Homo sapiens


      <400> 389
 tttttttttt ttttcttaaa tcaggttgta tttattaaaa acaaaataca aaataacttg     60
 gaattcagat tattgtgatg tttatcccct aacaggtcag tcctaaagaa aaagctaatt    120
 gtttcaaggg tggtaacgga agaattttaa gtaaggatta tattaaatac atctagtttg    180
 atgcaaactg agttttattc aatgttggag gcctcactat gttcctctaa gttttcaacc    240
 attaacaacc caaaccggtt gtttccctca taccaacact tggtgtgtgc agtggttctc    300
 cctctgttct tagaacagct ggtattctgt ttcttctgcc tttttttttt tgaatttgat    360
 ctaccttttg gtaggaatat ttcagcgggg gcatatgacc ttgtggcatt gaatagatat    420
 tcataaagtt gcttagcctc aggacatatg ctcaggagac tttctacaga ggtcgatgct    480
 agcagttgct ggcatagtcc gtgcaccagg cttccactgt acagtcgagt taggtctggc    540
 tctgggagag gagtggacag cagctggttg agatacatcc cccatctgga gacaggactg    600
 ccactgacag aagatgtgag ctgtgtctaa gtccagtctt gtgcccagcc gtgtctgcgc    660
 cttcactctt tggaactctg catacaacat cttagcacca tcttcctgca gctcttcctt    720
 accagggctg ttgattatgg caatcaaggg ccccactagc attgtgagca gtaaggattg    780
 tagatgatgt agctttgctt tggtctcggt gtgctgcaac cagtagcaac tgacagcaat    840
 gggcaacttc agtgaagtag ggattggctc cagaatggtc tgtttcacct tcagggtttc    900
 taacagaagc atctgccgcc tcctcaagga gagctcagtc aatctgctta agtcagaatg    960
 atccttggcc agttctactg catcaatgat tgaggttctg atatttttat taatcctttc   1020
 cacttcactg aaagctagag gctgaggagg caatgcattc caggatgtct tgtccagatg   1080
 tggtgaggca tttaaaagaa gcccatagat gatttgcctg atgggctgag atattctgtg   1140
 ggcatttggt tgctgcatgt tttccacctg tgtgggaaga atggtccgtc ttaggaccaa   1200
 agcatcactg atgaaaggag atagctggcc tttagctaaa gccactaata cccattctgg   1260
 taaaccaaga ttcaaggcat ctggacagac ataagtacca cactggaaga agtcctgtag   1320
 cttcacctgg gactgttggt attcttccat ggaacagcag agaagttcct taacattttc   1380
 tcgatccttt tttgggaggt atttcagaac attatctagt gcttcggtag ggttggcaaa   1440
 atgagacaac caattcagaa gtcccaggat tcggtggtgt ctcctccctt tagaactggt   1500
 agctccaaga ggaagacgcg ctttacttaa gaatgtctcc atgatgggta gattaacatg   1560
 gtcatttcca catagccccg caaagagagg tagtagagct ttattcatat tgctgaagtg   1620
 atggcagaat gcatcaaggg aaaagcattt ggcagggata tagttttgtg tgcccttaat   1680
 agtgttcata tttctccact gaaagctatt caatgggcaa aacccagttt tcaggtcaaa   1740
 aatgcaaaag tcactatctg atgataacac agggcaattc caatggttag caagtgtcat   1800
 aatgtcccga tctgcttctg aaaagcactg gacaaaacac acccgcagct tgatcaaaac   1860
 ctgtatgaat acttcccgga tgagtaa                                       1887



      <210> 390
      <211> 383
      <212> DNA
      <213> Homo sapiens


      <400> 390
 ccctaatcca tctgtgcatt cttctggtct ttttaaaggc agaggaataa acacacacac     60
 acacacacac acacacacac acacacacac acacacagag agaggagaga gagaaaagag    120
 ggagacagct tttttgtgtt ggtggaaagt tgtttttttt taggtaaaaa tgccgtgttt    180
 atatgaggga tgactgtgat cacaattcct atcatttttt tgtctctcct agataagttt    240
 agtataaatc aggctccaca gtgtcttagt gttttttaat aaaccagatc acactcattc    300
 gggtactctt tagggataat ttcacacagc agaagtcagc ccaaacttct ctagttatgt    360
 aacaaagcat gtagtggcca cgg                                            383



      <210> 391
      <211> 301
      <212> DNA
      <213> Homo sapiens


      <400> 391
 cgggactggt aaacatggcg ctgtacgttt cgccgattgt ttccggtgag gttatccgtt     60
 cccgtggcgg ctccacctct gaatttacgc cgggatatgt caagccgaag catgaagtga    120
 atccgcagat gaccctgcgt cgcctgccgg atgaagatcc gcagaatctg gcggacccgg    180
 cttaccgccg ccgtcgcatc atcatgcaga acatgcgtga cgaagagctg gccattgctc    240
 aagtcgaaga gatgcaggca gtttctgccg tgcttaaggg caaatacacc atgaccggtg    300
 a                                                                    301



      <210> 392
      <211> 369
      <212> DNA
      <213> Homo sapiens


      <400> 392
 tcagaatcaa cttcttccag acccctgtta atgttgattc tgacttttat aactgacagt     60
 ttcaaaagtc agaatcaact tcttccagac ccctgttaat gttgctattt tgatctcctt    120
 ccatgaaaca tcagtgtttt tattggcatc tagaatgctg aattctttcc agaagatttt    180
 ttctttgccc agattttgga tctgggcaaa gaggccagga attcttccta acatctgcaa    240
 tgcccaggag agctcctcca caacaaagga ttatccagcc aaaattgtca atagtgaaaa    300
 ggctgagaaa tcctatactg gagaaagcat gtggaaacag agaagaaaaa aaaattaaaa    360
 gacagaatg                                                            369



      <210> 393
      <211> 339
      <212> DNA
      <213> Homo sapiens


      <400> 393
 ttgcaatcag gctgtcagcc ttatgctcga actgaccata accagcgccc ggcagtgaag     60
 cccacatatt gctgcaacgg tcgattgcct gacggatatc accacgatca atcataggta    120
 aagcgccacg ctccttaatc tgctgcaatg ccacagctgc ctgacttttc ggagagaagt    180
 ctttcaggcc aagctgcttg cggtaggcat cccaccaacg ggaaagaaac tggtagcgtc    240
 cggcgcctgt tgatttgagt tttgggttta acgcgacaaa tttgcgaggg cgatcggagt    300
 aatcagagaa tagctctccg cctacaatga cgtcatatc                           339



      <210> 394
      <211> 681
      <212> DNA
      <213> Homo sapiens


      <400> 394
 ccaggaggaa tggagtctcc ttagtgaggc tcagagatgc ctttatcatg acgtgatgct     60
 ggagaacctg acacttatat cttctctagg ttgttggtat ggagcaaaag acgagacacc    120
 ttctaagcag accctttcta tacaacagga gtccccactc aggacacatt ggacaggtgg    180
 aaatgatgtc actctgaaac tcaggctgga atacactggc atggtcatac ctcactgcgg    240
 cctcaaactc ctggggctca agtgatcctc ctgcctcagc ctcccgagta cctgagatta    300
 gcccaggtaa ttcaagaatt ttttatagag atagggtttt gctattttac cctgactgat    360
 gttcaactcc tgggccttca agtaatcctc ttagccatac gccctttgaa agcactggga    420
 ttacaggtgt gagccaccat ggcccaggcc caaaaataat ttttgtagaa ttagcatttc    480
 taggtagtga agcagactgc aacagaatag ttgggatata ctttttttaa aaaggcatcc    540
 acaatgattc agtcactatg tctgtgatgg acaagcaggt acagaaattt tcaggacctc    600
 cataattatg aatctagtgt agcttaggtc attgtcagac taaatctaaa ggttttgtgg    660
 atttctgtag cctatcttgg g                                              681



      <210> 395
      <211> 375
      <212> DNA
      <213> Homo sapiens


      <400> 395
 ggataggaac aagaggacat caacttttac tgttcatctc ctatgagcca gacctgtcga     60
 ggagttgtat caatttcacc ccacttatcc taactagaac actggcatga cagaggagaa    120
 agcaaggtca gaaggagtaa ggagctagta gtcagtaaca ggctttcagg aatggtgatt    180
 ctgaatccaa acataatggg ggcttaacag cttctaacag cccaataggt tctaatacgc    240
 aaagaatgcc aagaaatctt aagacaaatt agtgtctcag tcttaccaag ggagaccagg    300
 ctgctatggt tctcctgctt ttcatctctg tagaggttca cctgagatga atccagctgt    360
 gtccacccag gagtg                                                     375



      <210> 396
      <211> 428
      <212> DNA
      <213> Homo sapiens


      <400> 396
 gatagggccc aaagcacatt taacagaaga gaaacctgat ggccttatca atgaagctac     60
 taggcaagtt gctttggcag atatcgttct cattaataaa acagacttgg ttccagaaga    120
 agatgtaaag aaattaagaa caacaattag atccataaat ggactaggac aaatcttaga    180
 aacacaaaga tcaaggctca gcagctgata gactcagcaa caggcagcca ggagctctga    240
 ggctcacagc tggcagtcta gttccactca gtctctactt gagaaattct ttctttggag    300
 gtacagcaga ggccttagaa tctcactctg gtttgagaca gagtctcact gtgtccccca    360
 agttggagtg cggtggtgcg atctcggctc actgaaacct ctgcctcctg ggttcaggcg    420
 attctcct                                                             428



      <210> 397
      <211> 764
      <212> DNA
      <213> Homo sapiens


      <400> 397
 gtcgcgataa acatatcaat aatttgaaaa agaaatgcca gaaggaatca gagcagaacc     60
 gggagaagca gcagcgtatt gagaccttgg agcgctacct ggctgacctg cccacactgg    120
 aagaccatca gaagcagagc cagcagctta aggattctga gttgaagagc acagagctgc    180
 aggagaaagt gactgagctg gagagtttgc tggaggagac ccaggcaatc tgcagagaga    240
 aggagattca actggaaagc ctgaggcaga gagaaacaga attctcctcc gctggacata    300
 gcctgcaaga taaacagtct gtggaggaga ccagtggaga aggtccagaa gtggaaatgg    360
 agtcctggca gaagcgatac gattcgctcc aaaagattgt ggagaagcag cagcagaaga    420
 tggatcagtt gcgctcacaa gtacagagcc tagagcagga agtggctcaa gaagaaggaa    480
 caagccaggc cctgagagag gaggcccagc gaagggattc agccctgcag cagctgcgca    540
 cagccgtgaa ggagctttca gtgcaaaacc aggacttgat tgagaagaat ctgacactcc    600
 aggaacacct gcgccaggcc caaccagggt ctccaccttc accagacacg gcccagctgg    660
 cacttgagct gcaccaggag ttggccagtt gccttcaaga tctgcaggct gtctgtagca    720
 ttgtgaccca gagggcccag ggccatgacc ccaatctctc cctg                     764



      <210> 398
      <211> 498
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(498)
      <223> n = a,t,c or g


      <400> 398
 ccgcgtccnn nnaaaaggan ccatggtatc atncgtggaa nctctctgng tctctgtagt     60
 gtcagagaaa gtagattcac ttattcttcc ctgtagatat gtgaagtaga aagtcttttg    120
 tcagatgaat tctttattgg atgcgcggtc actttcacta acgtccatgc tctttgtatg    180
 tgaggtctgt gtgaaaatgt gtgaccctgc caaaggagca gctggccaga gaaccatcgc    240
 tgcccttctg ccttgccttc tggacaaagg aatgatgagc accgtgacgg aagttcgagc    300
 cctcagcatt aacacccttg tgaagatcag caaaagtgca ggagccatgt tgaaaccgca    360
 tgcaccaaaa ctcattccag ctctgctaga gtccttaagt gtattggagc cccaagttct    420
 caattatttg agcctccggg cgacagagca agagaaggct gcgatggata gtgctcggct    480
 tagtgctgcc aaatcttn                                                  498



      <210> 399
      <211> 464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(464)
      <223> n = a,t,c or g


      <400> 399
 ggttagtncg gtggacttcc tacttgcctg gcaccgctcc cattttcttc tcttggtttc     60
 ttcacccacc tctgcttccc atttctcccc ttcccatccc catctacctt gcgccccatg    120
 tcctatagtc ttatcagagc ctgtagcccc agggggccca ggtgaggggc tgctcctgca    180
 ggataacgca atctccactg agatccaggc tttgctttcc tcctattaca gtgacaggtg    240
 atagggctgg gtaggcttgg ggcctgagct ctgactagcc caaccctccc ccaacccctt    300
 cctggtgcca cagttattga gccgctggat gacatctcag cggtgacaga cattctgacc    360
 catcgggagg gcgcaaggct ggagacaccc ccaccctggc tggcaatgtt tacagaccag    420
 cctgccctgc ctaacccctg ctcgcctgcc tcagtgggcc cagc                     464



      <210> 400
      <211> 878
      <212> DNA
      <213> Homo sapiens


      <400> 400
 tccgcaccgc aattcccggg tcgacgattt cgtatgtctg tgcccggatg attgttcgtg     60
 agtcatgaag ggaagtgaag agagtatgat attgaaggca gaggtttggg gagagggcat    120
 aggagaggag tatttgtagc agatgggctg tggctagagt tggtgtaagg caatgctatt    180
 agagattgag caagtagggt cccagacaga aaaggaaacc taagagtagc agcagtggta    240
 caaagggaaa gggcaatctg gaaccttatc tgaattttct ccccctttcc caagtcaaca    300
 acaagtttgg gcttcgctgt aagaactgca aaaccaacat ccatgaacac tgtcagtcct    360
 atgtggaaat gcagagatgc ttcggcaaga tcccacctgg tttccatcgg gcctatagtt    420
 ccccactcta cagcaaccag cagtacgctt gtgtcaaaga tctctctgct gccaatcgca    480
 atgatcctgt gtttgaaacc ctgcgcactg gggtgatcat ggcaaacaag gaacggaaga    540
 agggacaggc agataagaaa aatcctgtag cagccatgat ggaggaggag ccagagtcgg    600
 ccagaccaga ggaaggcaaa ccccaggatg gaaaccctga aggggataag aaggctgaga    660
 agaagacacc tgatgacaag cacaagcagc ctggcttcca gcagtctcat tactttgtgg    720
 ctctctatcg gttcaaagcc ctggagaagg acgatctgga tttcccgcca ggagagaaga    780
 tcacagtcat tgatgactcc aatgaagaat gggggcgggg gaaaatcggg gagaaggtcg    840
 gatttttccc ttcaaacttc attatttggg gcccggct                            878



      <210> 401
      <211> 120
      <212> DNA
      <213> Homo sapiens


      <400> 401
 aatacatgtg gtggggaagg acaggaacat cctctccagg gcctccgcac catactcgcc     60
 agcgtgcgcg ccgaccttac cccaggcggc cttgacgttg gtcttgtcgg caggacgaaa    120



      <210> 402
      <211> 384
      <212> DNA
      <213> Homo sapiens


      <400> 402
 aatacaggtg ggcatgtgct cttttatgtt tatccgatcc aggagatcct ccacagactt     60
 gggctggggt ggtcgtcctt tccgacgcct cctggtgggg cgtttgggtt tctcctcgtc    120
 ttcactgagc acgtccacgt agatgaactt gaacgtgccg actttgttgt tcagcaggcc    180
 catccaggtc cccatgggtg gcttgctgat tatatcgatg atatctcctt tcttgagctt    240
 gagtgagtct gtgtcatagg gactgggggt gaagtcggtg tgcaccctgt cacgcccgca    300
 gaacgggcct cggtaaggcg gctctttcgc atccccatct tccgaattga cgctttcccg    360
 gttggtggtt gaggaatcag tgcg                                           384



      <210> 403
      <211> 485
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(485)
      <223> n = a,t,c or g


      <400> 403
 ccgcgtcgaa gcttgatcct cagagcggcc gaatacatgg ggtgttgcga tacgcaggtc     60
 caggatgcgg tcgtacacgg ccttggtgga ctggaaggtg ccaaggctct cctccaggtc    120
 ggcgagcatg gaccagacct tcagtgactt gtacacgcgg ttctgcacgg gctctgaacc    180
 atcaaagtac tcggcccggc gggcaggcag cgccgtggcc tttcgcagca gccgcaaggc    240
 ctcatcgtag ttctcgtgtc ggagctccag ctctccgcac tgacaccaca cgcttgccag    300
 gtcatccacc tgcttgaagt tcaccttggt ggccttctcc aggatgacac gggcatcgtc    360
 cagctgtccg ttgtcctcat anaacttggc aaacgccacc cacagagtgt ggggcttggc    420
 ttgtgccttg gaggggtcca ccgtctgcac aaccctntgg gtaggtggtg gatgaactcc    480
 cgggg                                                                485



      <210> 404
      <211> 395
      <212> DNA
      <213> Homo sapiens


      <400> 404
 ttgccttcgt gccatggttg agggtctgcg ctgtgaagtt gctgcagctc ttaatgctct     60
 cctgcccctg gagcagagta tccagctgcg actggaggac tttgtgtttg aggccatagt    120
 tgacctccaa ttccataagc agcacactct tgcgcacatt taaagtcttc tggagctcat    180
 caaaggtgga atgaatgtca tccacgatgc tggccttttg gttggttaac tgatgaatga    240
 tttcagagat gaactgaaga gcagaatcta tttctgggag ccttttgttg acagcatcca    300
 actggacctg gagcgaggcc ttgtgctgtt ccaccacatc cttgagtgga actgtgggga    360
 gctctgcgtg ctccccctcc gtgcactccc gacaa                               395



      <210> 405
      <211> 402
      <212> DNA
      <213> Homo sapiens


      <400> 405
 ctcctataca catacgtatt actcgcatca ggagtatggg tggcctgagc ttaccatagg     60
 ctaatagaaa acaaccgaaa ccaaataatt caagcactgc ttattacaat tttactgggt    120
 ctctatttta ccctcctaca agcctcagag acacttacag tctcccttta ccatttccga    180
 cggcatctac gggtcaacat tttttgtagc cacaggcttc cacagacttc acgtcattat    240
 tggctcaact ttgctcacta tctgcttcat accccaacta atatttgact ttacatccaa    300
 acatcacttt ggcattcaag ccgccgtctg atactggcat ttagtagatg gggtttgact    360
 attcatgcat ggctccatct aatggtgaag ggcttaaaaa ag                       402



      <210> 406
      <211> 2165
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2165)
      <223> n = a,t,c or g


      <400> 406
 tttttttttt ttatttagga tctttttttt atttttatac acatgacaag attttaacac     60
 caagaatagt ccagttaaaa tagtacaaat ttacattcca tgaggaaatg ttaaaaaaaa    120
 ttccaactaa aaaacccact ttttcctgtg acccataatc ccaacatttt accagtgcag    180
 gggagaaggg ggattatgtg tgggcatcca aaacaagtct tctcccaaaa aagaaatgac    240
 ttcaaaactt cacatttccc ttctcacaca gggatccaaa tgggtgagga gtataatttt    300
 acaatttcat cttttttcag gctgtaggat tcctttggct ggtttcttct tcttcatctg    360
 tttcccacca tcccatttct tgcactcttc gtctctgctc tgtgtctttc tgcttgtgtc    420
 cttctgctgt ctctttcagg gttcttcctt cggggctctt cttccacctt tggcatcagg    480
 ggtcaaatgt tcaaaactga ggcgaagcat tctttccaat tccaatctcc atatgccttt    540
 agtgtctggg taaaaagata ccctgacccg agccgttgcc ggtttcaaac caaaaccaca    600
 agcaagatcc aaaactgttt tatcatcctt catcctcctt taattcgtcg aagcatgtct    660
 ctgatccagc ggtggtctgg gaattaattt caaatgtttt ctttctgact cgcatagtaa    720
 attgggtaag atgttctttg cccggttggt acgcttgtgc tttcatgaaa tctctcatgt    780
 tgccagacca atccgtactg ggctggccca cccaaagcaa ccacggagat tctgtcaggc    840
 gctgagacac cacagccttt tcaatcttgt ccttaagggc tttatctttc atccaattca    900
 gcagaggctc aaattctttc tcaactgctt cacgactctc cttagttttc tcactttcat    960
 cgaacttcac tccttccttg gcaacattct ggaacctctt cccatcaaat tcgggaaggg   1020
 cctgaataca gtattcatcc acaggttctg tgaggtaaat aacttcatag ccctttttca   1080
 gaagtcgctc aacaaatgga gaagattcag cctcttttct gctggaccca gccatgaagt   1140
 agattttgtc ttgtttttcc ttcattcttt ccacatactg gtctaggcta gtaatgtcag   1200
 ttggatgatg agaagactgg aacctaagaa gtttagcaag acgtgttcga ttcgagtggt   1260
 cttcaatcac accaagcttg atgttggtac caaattcttt ccaaaaagta tcattgtatt   1320
 tatcatcagc aatcttcttg atcatgtcca gcgttttacg aacaagcttc ttcctaatca   1380
 ccttaagcag tttatgttgc tgaagagtct cgcgggaaac attcaagggg agatcatctg   1440
 agtccaccac acccttgaca aaattgaggt atttaggcat catatcatgg aagtcgtctg   1500
 tgatgaatac acggcgcaca tagagcttaa tgtaatcgct ctttttagat ccatattcgt   1560
 caaacagacc acgtggagca gatgtgggta caaataaaat tgatttgaag gtaacttccc   1620
 cttcagcagt aaagtgaata taagccatgg ggtcatcact ttcctttgaa aatgatttgt   1680
 agaaagcttt gtattcatct tcttctactt cttttgatgg tctctgccat attggtttga   1740
 tatcattcat aagttcccag tcccagacag ttttttcaac ttttttagtc tttggtttct   1800
 tttcttcttc ttcttcctct actgcagctt catcatcaga ttcttctttc tcttctttgg   1860
 ctgcttcttc ttcctccatg ggctcctcaa cagtttcagt cttgctgctc catacataaa   1920
 taggaaagtt tatgaactgt gaatattttt tgacgagatt tttaattgta tccaattcaa   1980
 ggtaatcaga tgcagnagaa gaaacagcaa aggaatctac agctgaaaaa gatgaattgt   2040
 aaattatact ctcaccattt ggatcctgtg tggagaggga atgtgaaatt tacatcattt   2100
 cttttgggag agactttttc ctgtgaccca taatccnaca ttttacagta caggcggccc   2160
 ccccc                                                               2165



      <210> 407
      <211> 394
      <212> DNA
      <213> Homo sapiens


      <400> 407
 cccacgcgtc cggacgagtt ctagatcgcg agcggccgcc cttttttttt tttttttttt     60
 tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt    120
 tttttttttt tttttttttt tttttttttt tttttttttt tttaatttta tatattaaaa    180
 atattttttt tttttttcat tttggaaatt ttatgttatt tatcaaatta tggggtgggg    240
 gtgacataca aagaatgagt tattataagt aaatgttaga gagttacttt ttcttcacaa    300
 taaatatctt ttttattgga aataactacc tcatttcttt gatttacaac atttacgcgg    360
 ttaagaggca attataaatc tctaataaaa atag                                394



      <210> 408
      <211> 404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(404)
      <223> n = a,t,c or g


      <400> 408
 ggcagcacca cacctgccat ggaatttgca agtcttttta aaaaaatttt attgattgat     60
 tgtagagatg gggtcttgct ttgttgccca ggctggtcct gagctcctgg cctcaagtga    120
 ttttccttcc ttggcctccc aaatttttgg gattacgtac ataagccacc atgcctgacc    180
 acaatttgtg gttccaagag tgtgattttt atcatcattt gggaggatgt tggggcctct    240
 ggcatgactg atgactgtct ctgagtggag tgggctttgg aagggcgatg gggcttgctg    300
 gacaccccat tggaccgtca ttttgatgta ggaggcctgt gggttgtctt gccctttaaa    360
 tgtgggttgg tnggaacaaa actctggttt gtcacaggca tata                     404



      <210> 409
      <211> 380
      <212> DNA
      <213> Homo sapiens


      <400> 409
 gaatcatcat gcgactggct gaatgcctat ttaactctcg tgagatgtgc ccaggattga     60
 gcggactatt ttgctgaacg tctgtacaag tcgatgaagg gtgcggggac cgatgaggag    120
 acgttgattc gcataatcgt gaccagggcc gaggtggacc ttcatgggat caaagcaaag    180
 ttccaagaga agtatcagaa gtctctctct gacatggtac gctcagatac cttcggagac    240
 ttccggaaac tgctagtagc cctcttgcac tgagccatgc cagggcactt tgttcacagt    300
 gtggatccac ctttgttaag agcccattcc aaatcaaact ttctaatgaa actttctgac    360
 caaaaccctt tttatttccg                                                380



      <210> 410
      <211> 400
      <212> DNA
      <213> Homo sapiens


      <400> 410
 gaagcgtgaa gtccaaactt gctgtccaga ctctagcttg gctgggtctt tgcttgtacc     60
 acccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    120
 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aagggggggc tttaaaaaaa    180
 aaaaccaggg ggggaaaaat aaataattgg aaaaaaaaaa aaaatttttc ttataaaaaa    240
 ggtataaaaa aaaaaaccca aggagggtat tttaaaaaaa tggctgggga aaaaaaaatc    300
 attggggaaa atttttaaaa aaaaaatttt ttttgggggg aaaaaaaaaa aagaaaaccc    360
 cctaaaaaaa attaacctgc taggagaaaa aatatataat                          400



      <210> 411
      <211> 1124
      <212> DNA
      <213> Homo sapiens


      <400> 411
 tttttttttt tgaattttag catctggtga atttattcag cataaccaca ggcattatct     60
 tcatgctgtc acacacagac acaaacacag atacagcaca atatccatat ttagcccaag    120
 tgcattcctt ctgaggctca tttatatgtc ttcatatgcc acagcccatc atttaaataa    180
 tggatatttt caatgccaat tcctttgttg actttctcaa tgtcttctgc agacatcttc    240
 atgactccaa cacatagagc atgctgtttt ccttctgcca tgatagcaac aatggtatct    300
 actgcagcag ggtaaagctt agctccagga gaagttaagc ctggacacat gatatttgct    360
 ccactgagta caaatttgat ggctccttta tcaacctgct ggtgtggcag gataaaagga    420
 tatttgtgaa gtaatcttag ggttggataa aaaggccctt ctctttgtct aaaaaagagt    480
 aattctccat ttactgtaag gatttctata tgttcatggc atcggactat tttgacagga    540
 tctttcttag gcatgatttg attaagccat ggttcaatac ctggaaattg ctctatcaat    600
 tgattcttaa tacccttaat aactgaagtt ttcaactgga tgcagttgga cacattttct    660
 ttttcatcaa atttcttgaa catgatccaa ggtgaagggg gcgacgatag ggaagggccc    720
 ggaatgggaa agaaattgaa tttgcagggg tccggcagat cccctcacac gaggaaggcc    780
 ggcactgaca gtcggagctg tagtcgttat ccggaaaacg agagccagcc gcgctttacg    840
 gctctcagtc aaatctgact acttccgctc ctctggactc cacgtaggcg cttttgccgg    900
 ctccttttag gcaaccggtt cctcagcagt tggaggtagc tgaaagggcc cggaggaaag    960
 ccaggtactt caacttgttt ctgtagaaat tgccagaaat gttgatgcct tcacagcgtc   1020
 cgaccaccac cttccggccc agcagtacct gtttagcccc gatggccgcc aggcggccca   1080
 ggagatggcc tcgaccatca agcaccagga cctgcacctc cgcc                    1124



      <210> 412
      <211> 414
      <212> DNA
      <213> Homo sapiens


      <400> 412
 tttttttttt ttgaggacaa ggtctcactc tgtcacccaa ggtgggagtg cagtgacgac     60
 atcacagctc actggcagcc tcaacctggg gttcaagtga tcctctcacc ttcagcctcc    120
 ccaagtagtt gtgcctccta ggcacacaac actatgcccc ggcaaatttt ttgtattttg    180
 tattttttgt agaaacagga tttcgccatg ttggccaggc tggtctcgaa cacctgggct    240
 caactgatcc gcctgcctcg gcctcccaaa gtgctgggat tacaggtgtg agccaccctg    300
 ctcaaccagg ttttattatt taagttagtt aaactttgga tagattgtat aatatatagt    360
 ttaatgtaat catgctcata ttttttaaat aaataaaaca ctatactact gaaa          414



      <210> 413
      <211> 513
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(513)
      <223> n = a,t,c or g


      <400> 413
 gatcgatacc gtcgtgacat tcgancccat tnaataccac ccactatggg gaatctagcc     60
 ctcgggggca agaattcctc acgagggttt gtagattccc tgatctgcaa ttcttcccgt    120
 gccttcatgg attggagggc tctcctttct tccttgaatg actttgcatc cctctcgttt    180
 gctgagagtt gggacaatgt tggattactg gtggaaccaa gcccaccaca tactgtaaat    240
 acactcttcc tgaccaatga cctgactgac gaagtgatgg atgaggtgct gctaaaaaag    300
 gcacacctca ttctctccta ccatccgtct atcttccgac ccatgaagcg cataacctgg    360
 aacacatgga aggagctcct ggtgatccgg gctctggaga acagagtcgg tatctactct    420
 ccttatacaa cctaagaagc ttgcccccca gggcgtcaac aactgggtgg cctaaagggc    480
 ttggaacttt gacccttcag ccccaatcat tct                                 513



      <210> 414
      <211> 1040
      <212> DNA
      <213> Homo sapiens


      <400> 414
 tttttttttt ttctgagacg gagtttcact cttgttatac aggctggagt acaatggggt     60
 gatctcccct cactgcaacc cgggttcaag cgattctcct gcctcagcct cccgagtagc    120
 tgggattaca ggcatgcgcc accatgccca gctaattttt gtatttttag tagagacagg    180
 gtttcaccat gttggtcagg ctggtcttga actcctgacc tcaggtgatc cacctgcctc    240
 ggcctcccaa agtgctggga ttacaggcat gagccaccat gcctggccgg atgtgaatta    300
 tcttaaaaat tttcaggtaa ttctaatggg ccaaggttga gaacccctgc tctgggccca    360
 tccgagcacc aggctgtcac aaacgcatgc atgcactcac gcccgtgggc ttggggggct    420
 tcggaaatgt gcttctgctt ttttgagatg gggtctttct gttgcccatc ccggagcaca    480
 gtggcacgat cacagctcac tgcagcctcg acctcctggg ctcaggtgat cctcccgcct    540
 cagcctcctg agtgtctgct tctggttttc atgatgacct ggggcccagg catactacac    600
 ttgtgctgtt caggggccag tcctgcacca ggagcccatc agccacagct ccgccgagaa    660
 gcactgatat gcagagctaa gcagctttgt ttccacgtgg atcctgcgta ggttttcttg    720
 gtccatccgt agacaccgca ctcctgcaga ggatcttctc gggatgcccc actgtctctg    780
 ttttccctct tcactgaaca ctcagtcggg gctcgccatg atgcctctgt gtctgctggc    840
 ttctccccca ttggaacagc cttcttggca cgccacactg ctagctgctg ggcactgtgc    900
 tttctgcctt taccgttctg ccgtgatgtt gccaaaatag cagcaacaac aacaacaaca    960
 aaggctgggc acctggctca tgcctgtatt cccagcagtt cgagatcagc ctgggcaaca   1020
 tggtgagacc ctatctctac                                               1040



      <210> 415
      <211> 661
      <212> DNA
      <213> Homo sapiens


      <400> 415
 tgagagacgg agtttcactc tgtcccccag gctggagtgc agtagtgtga tctcggctca     60
 ctgcaacttc ttgtctccgg ggttcaagcg attctcctgc ctcagcttcc ctagtagtgg    120
 ggactacagg catgcaccac catgtccagc taatttttgt attttttagt agagacgggg    180
 tttcactata tgttggccag gctggtctca aacttctgac ctcaagtgat ccactcacct    240
 tggcctccca aagtgctggg attacagacg tgagccacca tgcccggcca gggattttcc    300
 actcttgaag ggagtatttt gttgtcactt tcaactcgct gttttttttt ccagacaacc    360
 tcaaatatga ccacactaca gcctgtacac aacaagacag tttatcttgg tccatggggt    420
 aagtgtatgc ctgatctttt taattcagta caatctctga aggtgttaac actaatgttt    480
 tacaagaatg tagaggcgac tcggtgctat gaagcgtgtt aaacaactca cacaattgct    540
 acaaaacacc agggaggggc tttttgtgtt tttaattttt aaaacatttt tccttttctt    600
 gtgagccata gtaggcctag agagattact gggtttttat aattaaacat ttatttcggt    660
 g                                                                    661



      <210> 416
      <211> 413
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(413)
      <223> n = a,t,c or g


      <400> 416
 ggtgagtagt gtgattgagg tggagtagat taggcgnnnt tacaaataga cgctaaggag     60
 ggtgatggtg gctatgatgg tggggatgat gaggctattg tttttctcgg cgctcaggaa    120
 gcatggcact ctggcgggca taccagcggg ccctggccgc tcacccgtgg aaagtacagg    180
 tcctgacagc tgacttctgg ggaggaaggc agcactgctg gccccatgcc agtagctata    240
 cctgccgacc caggcctcct ggactgaagg acacgcttcc tgctcctcac tccaagaagc    300
 cacttcttgc ccctctgcct tctgcgcatg aaactcaaaa gccacaaaac agctggtgga    360
 gaggcggggt ctgcaggaac accagagagg ccggactctg accatggtgt ccc           413



      <210> 417
      <211> 517
      <212> DNA
      <213> Homo sapiens


      <400> 417
 aatacagctg ctggcttgga tggagggctg agccactgac tcgtatacac ggagatggtg     60
 agatgcctgt tcaatctgag aatttctgta tgtgacttgt aggttgtagt atcccgtgtc    120
 ctctagggtg acgttctgga aatgcagatc tccactgggt gatattgtct ctcgaccgct    180
 gtatgcaggc cctggagtcc taacgtgagt gtctattaca tatgctgcga ttagctggtt    240
 gggctccacc gttttccctt tgtaccagcc atagctgtaa agattctcgc gcagataaac    300
 cacagagaga tgaacattct ccccttcagc aacttcatag ggcgctgatg caataaagag    360
 ccaggcagtg gtgggtgcct ctcacaaagc taacatgtga tgctgtgagc aagagcccct    420
 gcccgggatg cattttcttg ggggaccccc tgagggggcc cccaagtctt tgcctgctgg    480
 tctgttcttc tttgggacaa ggccttggct tccgacg                             517



      <210> 418
      <211> 621
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(621)
      <223> n = a,t,c or g


      <400> 418
 cgacgatctc gtgcgttgcc ggcgaagagg ggagcctgac gactcggaaa tttgaatacc     60
 acagtagcat ggagtgtgac ctcatggaga ctgacatctt ggagtcgttg gaagatctag    120
 gttacaaggg cccattgttg gaagatggag cgctctctca ggcagtctct gctggagcca    180
 gttcccccga gtttaccaaa ctctgtgctt ggctggtgtc tgaattaaga gtgctctgta    240
 aactagagga aaacgtgcaa gcaactaaca gtccgagtga agctgaagaa ttccagcttg    300
 aggtgagtgg gctactaggg gagatgaact gcccgtatct ttcactgaca tctggggatg    360
 tgaccaagcg ccttctcatt cagaagaact gcctcctctt gctcacatac ctcatctcag    420
 aactagaagc tgccagaatg ctctgtgtga atgctcctcc aaaaaaaagc tgaagaattg    480
 gaacatagtt atattggctg gaggtttgga cattcctaga gcaatacata tgcctttcaa    540
 ctcttgaaag acctcactcn cgcctccttc ttgcggacgc gtgggtganc cnnnaattcc    600
 ggacgggtac cgcagtgaac g                                              621



      <210> 419
      <211> 354
      <212> DNA
      <213> Homo sapiens


      <400> 419
 gaaggggaga gctacagagt gattaccccc caaacgccca cccaataggg tttagaagct     60
 taaataccac ctaaaggtta caaaaagagt gtgggctcgg atcagtggca taacatgttc    120
 ggggagctgg agaaggggaa gcctggctag caaaggtggt cttgttatgt aaatgaagcc    180
 ccacaggtgg cagccctcaa aagaatagat ggtaaatgtt ttagaccttt tttgttgtat    240
 gagacagagt ctcgctctta ttgcccaggc tggattgcaa tggcacgatc ttggttcact    300
 gtggcctccg cctcccgggt tcaagcgatt ctcttggcct cagcctccca agtg          354



      <210> 420
      <211> 368
      <212> DNA
      <213> Homo sapiens


      <400> 420
 gcaacctcaa acagacacca tggtgcacct gactcctgaa gagaaggctg ccgctactgt     60
 cctgtggggc aaggggaacg tggatgaagt tggtggtgag gccctggtca agctgatagg    120
 ggcctaccct tggacccaga ggttctttga gtcctttggc gatctgtcca ctcctgatgc    180
 tgttatgggc aaccctaacg ggaaagctca tggcgcgaaa gtgctcggtg cctttagtga    240
 tggcctggct cacctggaca acctcaaggg cacctttgcc acactgagtg agctgcactg    300
 tgacaagctg cacgtggatg ctgagaactt atgctcctgg gcaacgtgct cgtctgtgag    360
 ctggcccc                                                             368



      <210> 421
      <211> 418
      <212> DNA
      <213> Homo sapiens


      <400> 421
 ggatttatag ggcaggtcat gggcaactga cccacatgaa aaaccaattg aattttaaat     60
 tcctcggcca gaggttaaat caagttatat ttcactcata aaatttctta acttgggcag    120
 agatactgtc ctttaatcaa tcttcaatgc tgcttaaata ataagtgtta agagatggat    180
 ggagcctggc caacatggca aaacaccacc tccactaaaa atacaaagat tggctgggca    240
 ttccaggtgc ttagggggct gagacataag aattgcttga acccgggaga tggaggttgc    300
 agtgaaccga gagtgttcca ctgcactcca gcctgggtga cagaggaaga ccctgtctcc    360
 ctgtctaaaa aaagagagat ggatgggaat aatactacct tcacaccaag ccagttga      418



      <210> 422
      <211> 418
      <212> DNA
      <213> Homo sapiens


      <400> 422
 ccacagactc agagagaacc gaccatgggg ctgtctgctg ccgactagac caacgtttag     60
 gccggctggg gtaaggtcgg cgcgcacgct ggcgagtatg gtgcggaggc cctggagagg    120
 atgttcctgt cctttcccac caccaagacc tactttccgc acttcgacct gagccacggc    180
 tatgcccagg ataagggcca cggcatgaag gtggccgacg cgctgaccaa cgccgtggcg    240
 cacgtggacg acatgcccaa cgcgctgtac gccctgagcg acctgcacgc gcacaagctt    300
 taggtggacc cggtcaactt caagctccta aaccactgcc tggtggtgac cctggcctgc    360
 cacctactcg ccgaggtcac ccctggggtg cacgccttcc tggacaaatt tcctggcg      418



      <210> 423
      <211> 440
      <212> DNA
      <213> Homo sapiens


      <400> 423
 gttgggtgga aaaagacttt cttctctatt ttcctagtta tatatgctat catatgtctg     60
 ttatactcct cttgaagtta ccctgaaacc tgggctcttg aagacgcatc actggagcag    120
 atggataatg gatactgggg ctatatgatg actgacccag tcacattaaa tgtaggtgga    180
 cacttgtata caacgattct caccacattg acgcgttacc cggattccat gcttggagct    240
 atgaatgggg gggacttccc cacagcttga gaccctcaag gcaattactt tattgatcta    300
 gatggacctc ttttccgata tgtcctcaac ttcttaagaa cttcagaatt gaccttaccg    360
 ttggatttta aggaatttga tctgcttctt aaataatcag atttttacca gattgagccc    420
 ttgattcagt gtatcaatga                                                440



      <210> 424
      <211> 341
      <212> DNA
      <213> Homo sapiens


      <400> 424
 ggcacgagcc aggggcgttg ggaacggttg taggacgtgg ctctttattg gtgagttttc     60
 catttacctc cgctgaacct agagcttcag acgccctatg gcgtccgcct cgacccaacc    120
 ggcggccttg agcgctgagc aagcaaaggc ctcaatccac taattccttg cgctctccgc    180
 tgggcccgct gtctgttctc cgacgcctac ccgggacgcc tccctgggat gcttctggcg    240
 cgcagtggtc ctcgcggagg tgatccaggc gttctccgcc ccggagaatg cagtgcgcat    300
 ggacgaggct cgggataacg cctgcaacga catgggtaag a                        341



      <210> 425
      <211> 354
      <212> DNA
      <213> Homo sapiens


      <400> 425
 gcccaggctg gtcttgaact cctgacctca agtgatccac tcaccttggc ctcctgaagt     60
 gctgggatta caggcgtgag ccaccacgcc cggcctgtgt tctcatttcc tcctattgtc    120
 caaatgccac accctctgtg aagccttcct gatttccata atcaattaat tctcctttct    180
 ctacaatatg tacctcacta gattttttta ttaagtgagg tagggaataa aataataaga    240
 gcttgccttt aacaagtact taccatagaa taggcatttt gataagtgct tgacaagcat    300
 aatctcattt tacctcataa cactgaggta gatgctatta ttatccccct ttta          354



      <210> 426
      <211> 334
      <212> DNA
      <213> Homo sapiens


      <400> 426
 ttggcttgta tatcatattg gccacttccc ttatagctta ttccaagcca ccaaggaagt     60
 ccttgcttat cctagaagat gaaaaagcat gagaaccaag acctagctgt taactcttct    120
 agaagtgaat aaaatttacc aatttcacct cttttttttt tttttttttt ttttttttaa    180
 aaaaaaccct gggggggccc cccgggtggg aaataggggt taaagctaaa ttttttggac    240
 cctccccccc ccgggttaaa aaaatttttt ttcctaaccc ccccaagggg gggggataaa    300
 aagccccccc ccccctgccc gtatattttt ttgt                                334



      <210> 427
      <211> 455
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(455)
      <223> n = a,t,c or g


      <400> 427
 nttcgaagat agatagacca gtgcggcgga attcctagcg ttaaaggcac tgcagagaaa     60
 tgaggtgcag aggtggcccc tctgagtatt tattttactc aggtaccagt ggtacatata    120
 tacagtgtaa ttatgaccag gctggtaaaa ttggctgctc gcaaacaatc cccttttttc    180
 ctggcagtat ttggaattta tcatttatta ataactatac atttttaaag gcagaagaag    240
 aaaatctatc tatctatcta tctatctatc tatctatcta tctatctatc tatctatcta    300
 aatgacctga cagaagaaaa ctgttaaaaa tggatattat tggaggggat ttaaaacagt    360
 gggtgtgaat tatcattctg atggaaagaa aatagcaaaa caatgtgtta caagtatttg    420
 ctaataaaca gtatactgcc agcttctaat tgctn                               455



      <210> 428
      <211> 389
      <212> DNA
      <213> Homo sapiens


      <400> 428
 attagccggg cgctcctgtc atcccagcta ctcatgaggc agaggttgca gtgagccaag     60
 atgacgccac tgcactccag cctgggtgac agactatgac tccatctcaa ataaaaatta    120
 aactgggggg gactttataa aaaacattat gaggaactta caggatgcca ttattgggag    180
 tgtgtacttc catgttgaaa gggtaaacag gctaaattga ctcactgctt taaaagagaa    240
 agaaaatatt gtgggcggga tttgctcctt cttctacccg agcagaatga ctgggttctg    300
 aaacccaaaa gacctcatta gatttgtagt gggtatatat ttgaacgtag agtcatctca    360
 taaaattttt gtacaacagc ctctctcct                                      389



      <210> 429
      <211> 404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(404)
      <223> n = a,t,c or g


      <400> 429
 ttttgctggt ggctttgttg actttggtgc ttgtgatggc ggcctcctca ctggcaatga     60
 gaagatcacc atgcaggcac actcatcaca gcgctaagct cgcactgatt ttttacctga    120
 gtaggcctag aaataaacat gctagctttt attccagttc taaccaaaaa aaaaaaaaaa    180
 aaaagggggg gcccttttaa aggaaccaag tttaaggccc gggggggggg aaggaaaaat    240
 ttttttaagg gggccccaaa attaaattcc ggggccgggg tttaaaaacg gggggggggg    300
 aaaaacccgg gggtaaccca aataaaagcc ctgtggaaaa annnnnnnnn nnnttntgnn    360
 ntgnttnagg cncaataagt tgctggtttt tatcaaaaaa aaaa                     404



      <210> 430
      <211> 473
      <212> DNA
      <213> Homo sapiens


      <400> 430
 gcgtttctga ggagaaactc ttggtgagaa ttcccagagt gataggggct acctacagcc     60
 tggcgaacga gagactacgc gctctggaag acattgaacg ggaaatcggc gccatccttc    120
 agaatgcagg tactgtgatc ctagaattgt ccaaggaaaa aactaacgag cggctcctag    180
 accggcaggc ggcggccttc accgcttcag tgcaacacgt ggaggcggag ctgtcagctc    240
 agatccgcta cctcacccag gtggccacag ggcagcccca tgagggctcc agctactctt    300
 cgaggaagga ctgtcagatg gctctgaagc gagtggacta tgcccgcctc aagctcagtg    360
 atgtggctcg aacctgtgag cagatgctgg agaactaggc cagggagatg gacccagagc    420
 tgagagggag accatcacct gtgccatggg acagaacctg ggaacatgta ggg           473



      <210> 431
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 431
 gccttgagtc tgtcctggtc tctggaatca cggagtctag taaaggccag cacacagcag     60
 atatataaat gtacaaatga gtgaatgaag agaatctgat tggccttaag gaacttacgc    120
 acttaaaata attgggcata agagaagcag tgaaggagtg cagaggcatc acctgaaagg    180
 gatcactgag attctgatga acagaccttc tgcccgcaat gccttgggga atgtcttcgt    240
 cagtgagctg ctggaaactc tggcccagct gcgggaggac cggcaagtgc gtgtcctgct    300
 cttcagaagt ggagtgaagg gcgtgttctg tgcaggtgca gacctgttgg atcgggaaca    360
 tatgagttga tgctcaggag gggctgttgg aaggctttat atttattcgg g             411



      <210> 432
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 432
 gccttgagtc tgtcctggtc tctggaatca cggagtctag taaaggccag cacacagcag     60
 atatataaat gtacaaatga gtgaatgaag agaatctgat tggccttaag gaacttacgc    120
 acttaaaata attgggcata agagaagcag tgaaggagtg cagaggcatc acctgaaagg    180
 gatcactgag attctgatga acagaccttc tgcccgcaat gccttgggga atgtcttcgt    240
 cagtgagctg ctggaaactc tggcccagct gcgggaggac cggcaagtgc gtgtcctgct    300
 cttcagaagt ggagtgaagg gcgtgttctg tgcaggtgca gacctgttgg atcgggaaca    360
 tatgagttga tgctcaggag gggctgttgg aaggctttat atttattcgg g             411



      <210> 433
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 433
 gccttgagtc tgtcctggtc tctggaatca cggagtctag taaaggccag cacacagcag     60
 atatataaat gtacaaatga gtgaatgaag agaatctgat tggccttaag gaacttacgc    120
 acttaaaata attgggcata agagaagcag tgaaggagtg cagaggcatc acctgaaagg    180
 gatcactgag attctgatga acagaccttc tgcccgcaat gccttgggga atgtcttcgt    240
 cagtgagctg ctggaaactc tggcccagct gcgggaggac cggcaagtgc gtgtcctgct    300
 cttcagaagt ggagtgaagg gcgtgttctg tgcaggtgca gacctgttgg atcgggaaca    360
 tatgagttga tgctcaggag gggctgttgg aaggctttat atttattcgg g             411



      <210> 434
      <211> 398
      <212> DNA
      <213> Homo sapiens


      <400> 434
 ggcacgaggg ctcggcgtgg tattcttcca ggatcttata gtgcagttct gaagacaaag     60
 aagactcttt ctatcctagg aattctaaga aaaaatgtaa agatttttca aaacaccagg    120
 tgttttgttt tgttttgaga cgagagtctt gctctgtcgc ccgtgctgga gtgcagtggc    180
 gcgatctcgg ctcactgcaa gctccgcctc ctgggttcac accattctcc tggaaggggg    240
 aggatgcagt gagcctaaat cgctccattg cacctcagcc tgagcgacag agtgagaccc    300
 tcggctccaa tagactaaga agatggagaa agaactacaa ggcccggcga gggggccaca    360
 tgcctgtact ccaagtactt tcgtagggca aggcgaag                            398



      <210> 435
      <211> 391
      <212> DNA
      <213> Homo sapiens


      <400> 435
 agaatgaaga ctattctcag caatcagact gtcgacattc cagaaaatgt cgacattact     60
 ctgaagggac gcacaggtat cgtgaagggc cccagaggaa ccctgcggag ggacttcaat    120
 cacatcaatg tagaactcag ccttcttgga aagaaaaaaa agaggctccg ggttgacaaa    180
 tggaggggta acacaaagga actgtctacc gatcggacta tgtgcattca ctgtcacaac    240
 atgatcatgg tagttatcca tgtatggtaa tgcattgcta tgctggtcta gtcgatcatg    300
 agtattcttc gagatggagt tttactcttg ttgcttaggt aggagacatg cttgagcccc    360
 ggaggcagta tgtggcagga cccgggatcg g                                   391



      <210> 436
      <211> 399
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(399)
      <223> n = a,t,c or g


      <400> 436
 tcgcggacgc gtgggtctca agtgatctgc ctaccttggc ctcccagagt gctgggattg     60
 caggcatgag ccactgcacc cagcccaaag tatgctttta aaaatatgta tatatataaa    120
 atttttgaaa agcaaattat gatataattc aagtatcaaa ttacttcatg ctgtttcatt    180
 gttcctattc acatgcgaaa gcatgtgatc aattattgct gcatcacata tagactcatt    240
 aggtggaaat tatggcctct tctgtaaaaa agtaaggaca ttaaaatgta agatgcttga    300
 tgaaaatcta agtggagagg ctctttgtgg ctaacttatt gagtgatgta tgaggtcgat    360
 gttcagagta atatgcctct gtattatagt ggtagaaan                           399



      <210> 437
      <211> 299
      <212> DNA
      <213> Homo sapiens


      <400> 437
 tgtttcactt cttcagaaag cctccggaat ctaaaaagcc ctcagtacca gagacagaag     60
 cagatggatt cgtcctttta ggagatacaa cagatgagca aagaatgaca gcaagaggca    120
 aaacttcgga catagaggcc aaccaacctt tggagaccaa caaagaaaat tcatccagtg    180
 tgactgtatc agaccctgag atggaaaata aggcaggcca gactctggag aacagctcat    240
 taatggccga gcttctgagc gatgtgcccg tcaccctcgc cccgcatgtg ctggcagga     299



      <210> 438
      <211> 329
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(329)
      <223> n = a,t,c or g


      <400> 438
 gtcaggtatg tcaaagaaca ttggcggagt cgaatagcat ctatccagcg agtcctgtaa     60
 gacttcatgc tcttccactt ccattagcac accgctgagc ctggaaaagc agactaaact    120
 atggaagcgg ccccggaaaa tcatacacca cagagcccca ctagatttca gagagcacgt    180
 atggaagggg cctgaaaaga aaaggataga tccattagat gcattaatga ggtaaaaaaa    240
 aaaaattatt gcctttattt ggggatagaa aagggccagg tngaaaacat tgaaggagaa    300
 agacagagag accgagacag agaccgaga                                      329



      <210> 439
      <211> 363
      <212> DNA
      <213> Homo sapiens


      <400> 439
 taactcggcc ccggaggcgg ggagctgctg gaagatgaag gtgaacatct ccttcccagc     60
 cactggctgc cagaaactca ttgaagtgga cgatgaacgc aaacttcgca ctttctatga    120
 taatcgtatg gccccagaag ttgctgttga cgctcttgtt gaagaatgga agggctatgt    180
 ggtccgaatc attggtggga acgacaaaca aggtttcccc atgaagcatg gcgacttgac    240
 ccatggccga gtccgcctgc tactgagtaa ggggcattcc tgttacagac caaggagaac    300
 tggagaaaga aagagaaaat cacttcgtgg ttgcattgtg gatgcaaatc tgagcgttct    360
 cat                                                                  363



      <210> 440
      <211> 415
      <212> DNA
      <213> Homo sapiens


      <400> 440
 ccaagaattc ggcacgagcg ctgttttgcc ggaggagccc ctcaggccgt agtaagcatt     60
 aataatgtct ttcatctttg aggggatcta cgatggcttc agcagtgtgc tccagttcct    120
 aggactgtac aagaaatctg gaaaacttgt attcttaggt ttggataatg caggcaaaac    180
 cactcttctt cacatgctca aagatgacag attgggccaa catgttccaa cactacatcc    240
 gacatcagaa gagctaacaa ttgctggaat gacctttaca acttttgatc ttggtgggca    300
 cgagcaagca cgtcgcgttt ggaaaaatta tctcccagca attaatggga ttgtctttct    360
 ggtggactgt gcagatcatt ctcgcctcgt ggaatccaaa gttgagctta atgct         415



      <210> 441
      <211> 473
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(473)
      <223> n = a,t,c or g


      <400> 441
 ggagggcttt taattgaaac ccattgagan gcgtggaatt ccccggctcg agcggcccaa     60
 cccttccctc accctggcac cagacaccca ggacttattt aaactctgtt gcaagtgcaa    120
 taaatctgac ccagtgcccc cactgaccag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    180
 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaggg gggcccttta    240
 aaaaaaaagg gccctaaaaa acccggaaaa aaccccgggg gggtttttta aaggcccacc    300
 cttttggggg gggccccccc ccggggtttt ttttggcggg ggggggggcc cccccacttt    360
 tttttttaaa aaaaaaaaaa aaaatgttct tctttttggg gaaggggggt tttttttttg    420
 gggncnnaac aaaaaacgag actcgagata tctctaaaga agaatagtaa atn           473



      <210> 442
      <211> 429
      <212> DNA
      <213> Homo sapiens


      <400> 442
 gcgagcgtaa gttaacttga caggtctgag ctaaagataa ccccacaccc actccacctt     60
 actaccaaac aaccttaccc actacattta cccacagaaa ggatacgcga tccaaatcgt    120
 tacctggcgc actagagatt ggaccgcaag ggacagatga gaaaccatca ccatgcgtaa    180
 catagcaggg actaacccct ataccttctg catatgagaa ttggctccac ttcaaagcct    240
 ccggaagggg ccaggcctgc tgagcccccc cagagcctgc cctgttccta cccctgctgt    300
 cagccgtacc ctgctgggca actttgagga atcattgctg cgaggacgtt ttgcaccatc    360
 tggtcacatt gatggctata cagcagaaat tggagctagt gggtcatact gcccccagca    420
 cgtcacact                                                            429



      <210> 443
      <211> 1204
      <212> DNA
      <213> Homo sapiens


      <400> 443
 agcggggccg gggctgcggg gcgagttgtc ggccctgggc cgggagctgg agtcccagac     60
 tcataggtcc cggcccagcc cccgaagagc cgcctcagcc ggggggagtt gctcggactc    120
 aaacgtccag tcctcgtgcg accgcgctgg gtcggaagtg agcaggctga ggccaccatg    180
 gagcagtgtg cgtgcgtgga gagagagctg gacaaggtcc tgcagaagtt cctgacctac    240
 gggcagcact gtgagcggag cctggaggag ctgctgcact acgtgggcca gctgcgggct    300
 gagctggcca gcgcagccct ccaggggacc cctctctcag ccaccctctc tctggtgatg    360
 tcacagtgct gccggaagat caaagatacg gtgcagaaac tggcttcgga ccataaggac    420
 attcacagca gtgtatcccg agtgggcaaa gccattgaca ggaacttcga ctctgagatc    480
 tgtggtgttg tgtcagatgc ggtgtgggac gcgcgggaac agcagcagca gatcctgcag    540
 atggccatcg tggaacacct gtatcagcag ggcatgctca gcgtggccga ggagctgtgc    600
 caggaatcaa cgctgaatgt ggacttggat ttcaagcagc ctttcctaga gttgaatcga    660
 atcctggaag ccctgcacga acaagacctg ggtcctgcgt tggaatgggc cgtctcccac    720
 aggcagcgcc tgctggaact caacagctcc ctggagttca agctgcaccg actgcacttc    780
 atccgcctct tggcaggagg ccccgcgaag cagctggagg ccctcagcta tgctcggcac    840
 ttccagccct ttgctcggct gcaccagcgg gagatccagg tgatgatggg cagcctggtg    900
 tacctgcggc tgggcttgga gaagtcaccc tactgccacc tgctggacag cagccactgg    960
 gcagagatct gtgagacctt tacccgggac gcctgttccc tgctggggct ttctgtggag   1020
 tcccccctta gcgtcagctt tgcctctggc tgtgtggcgc tgcctgtgtt gatgaacatc   1080
 aaggctgtga ttgagcagcg gcagtgcact ggggtctgga atcacaagga cgagttaccg   1140
 attgagattg aactaggcat gaagtgctgg taccactccg tgttcgcttg ccccatcctg   1200
 tatt                                                                1204



      <210> 444
      <211> 882
      <212> DNA
      <213> Homo sapiens


      <400> 444
 atagagttcg atacacaagc ggaggaattc ctggagcgtt cggcggacag tgagcatgcg     60
 taccatatct gaagttcgta aattgaaatt gaacatgcgt aattaatctt tctgaatagg    120
 aaaaaatata tacacaacaa aactctccgt ttatggaaca tgcgcatttg ttctcagtaa    180
 gtttttcgtt ttgaaagtga gcatgcgcat ggtgagtagg ttggtccgaa gtttgaaccg    240
 gacagaagcg ctggtcggcg tctggcggtt gtttttagag gtaatacacc tagtttgtgg    300
 ctcagcatgt caattgtaac agtgcaactt ggtcagtgtg gcaatcagat tggttttgaa    360
 gtttttgatg ctttgcttag tgactcacac agttcccagg gactctgctc tatgagagag    420
 aatgaggcat atcaagcatc ttgcaaagaa agattcttca gtgaggagga gaatggagtt    480
 ccaattgccc gggctgttct tgttgacatg gaacccaaag ttatcaatca aacgctgtca    540
 aaggctgccc agtctggcca atggaaatat ggtcaacatg catgcttctg tcaaaaacaa    600
 ggttctggaa acaactgggc atatgggtaa gaataatttc ttgtgatttt cagtttagtg    660
 acagctacac agtcaattaa tagatagcaa agttagaact gtatagttga tataccaagc    720
 acataatctt gaaattgctg ttttagattt agaattttat tttacccaga agaaactttc    780
 attccatgcc tatgtctgta cttaaggtac aggtaatgtt gaaatgaagg atatctttca    840
 gcagggtttt ccatcttctc actgtcatgc tgcaaactaa ct                       882



      <210> 445
      <211> 882
      <212> DNA
      <213> Homo sapiens


      <400> 445
 atagagttcg atacacaagc ggaggaattc ctggagcgtt cggcggacag tgagcatgcg     60
 taccatatct gaagttcgta aattgaaatt gaacatgcgt aattaatctt tctgaatagg    120
 aaaaaatata tacacaacaa aactctccgt ttatggaaca tgcgcatttg ttctcagtaa    180
 gtttttcgtt ttgaaagtga gcatgcgcat ggtgagtagg ttggtccgaa gtttgaaccg    240
 gacagaagcg ctggtcggcg tctggcggtt gtttttagag gtaatacacc tagtttgtgg    300
 ctcagcatgt caattgtaac agtgcaactt ggtcagtgtg gcaatcagat tggttttgaa    360
 gtttttgatg ctttgcttag tgactcacac agttcccagg gactctgctc tatgagagag    420
 aatgaggcat atcaagcatc ttgcaaagaa agattcttca gtgaggagga gaatggagtt    480
 ccaattgccc gggctgttct tgttgacatg gaacccaaag ttatcaatca aacgctgtca    540
 aaggctgccc agtctggcca atggaaatat ggtcaacatg catgcttctg tcaaaaacaa    600
 ggttctggaa acaactgggc atatgggtaa gaataatttc ttgtgatttt cagtttagtg    660
 acagctacac agtcaattaa tagatagcaa agttagaact gtatagttga tataccaagc    720
 acataatctt gaaattgctg ttttagattt agaattttat tttacccaga agaaactttc    780
 attccatgcc tatgtctgta cttaaggtac aggtaatgtt gaaatgaagg atatctttca    840
 gcagggtttt ccatcttctc actgtcatgc tgcaaactaa ct                       882



      <210> 446
      <211> 459
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(459)
      <223> n = a,t,c or g


      <400> 446
 nttgannntt gtaagacact cttgaccatc attannacag cttggcacga ggcgcacatc     60
 cgtcgagccc gaggggagat ttgccggttc aattttaact gcgatattga tcttgggggt    120
 gactgtccct ggccggctgt cgggtgggag tgcgagtgtg cactcgctcg gaagtgtgtg    180
 cgagtgtgta tgtgtgtgtg ccgtgtcggg ctcccccctt ccccccgttt tcccgtcgag    240
 tgatgcactt ggaatgagaa tcagaggatg gaaatagtct gggaggtgct ttttcttctt    300
 caagccaatt tcatcgtctg catatcagct caacagaatt caccaaaaat ccatgaaggc    360
 tggtgggcat acaaggaggt ggtccaggga agctttgttc cagttccttc tttctgggga    420
 ttggtgaact cagcttggaa tctttgctct gtggggaaa                           459



      <210> 447
      <211> 387
      <212> DNA
      <213> Homo sapiens


      <400> 447
 atactttcag tgtatattat atctacatgc atacattgtg tatgtatgta gatgtatatc     60
 tacatacatt gaaagatata tatctacata ctatacaatg catgtatgat acctttggct    120
 actacatcct tcttaaattt cctgttgcca cttatgacct gatttccttg accagttatt    180
 cctccttcaa acatccctct tacatgtgat agtcctcagc atttagtttc cccaactttc    240
 ccctaattat cagttgactc aattaccacc aaaatatcaa tgactttttt gagacagagt    300
 ctcactctgt caccaggctg gagtgcagtg gcacgatctt ggctcagtgc aacctctgcc    360
 tcctgagtcc aagtgattct cctccct                                        387



      <210> 448
      <211> 439
      <212> DNA
      <213> Homo sapiens


      <400> 448
 tagaggcata tagtgatagg cgaggggaaa cttaagggtc aacctggagc atccgtggca     60
 gctccatgcg tgaggctggt gccacacagt atcccggtgt tggcattgtc tccaggcctt    120
 ctctgttccg cacgcagtta caaaacaaaa gaacagttgc cagcagttga aagaggatgt    180
 ggatccaaac caaatggggg acagatactc cctctatgga ctagatactc atggaagaag    240
 tcaagttaga agagcaactg aaggaggttg tggaagaata taagcttgca ttgtcagata    300
 ctgagggctt gcagcagagc atccaaaaat tggtggatga ggcaaatatg tgtagcattc    360
 aaggcttctg catggactcg ttagaggttg cagatgttct ggagaacggc acacagtgtg    420
 tttcatagca gaaattcag                                                 439



      <210> 449
      <211> 2173
      <212> DNA
      <213> Homo sapiens


      <400> 449
 gaattcccgc tgtcgaccca tgcgtccggc aaggtcaagt ctggatgatt actgtccttc     60
 tgaccaagtt gattctattc atgaaaaggt cctcaatatg ctacgtgccc tctatggaaa    120
 tctagacctc caagtgtatg cagcagagtc tcctccatct tgaaacaaac aaaacattag    180
 gctcctgttg tatcttggtt tagtaacagg cccttaatta acttatttgt acatgagtct    240
 tccagagaac actgttttat attaactttc agttgaaatc tttcagatat tttgaatctc    300
 tgaacaacca ttgtcagttg tgaatgatgg taaatttttt ggcatcaagt ctcataaccc    360
 caactgatag aactgttgct tatctgtctt ccttaagtat tttttagggt tttgtttttt    420
 tttttgttgg tttgtttgtt tgtcttcact tttcccccag ggtctgttga gctgtatgag    480
 attcattcat acttcattaa ttcattcaac taatatttgt tgaacactta catgtaccag    540
 acattattaa gtgctgggta tatggtaatg aacaaaatag acaaggcccc tgccctttta    600
 ggggagacag atgaaaagta aattccgggt tatgagaaat gttttgaagg aaaggacaac    660
 aacagacatg tcttagtact tagggtatca tggctttata ggaaagtaac attctctatc    720
 tttttttttt ttttaatttt ataaaaataa agatggggtc tcaccatggt tacccaggct    780
 ggtctcaaac tcctgggcac aagcaatcca cctgccttcg ccctcccgaa gtgctgggat    840
 tacagatgta agtcactacc cccagcccag aaactaacat tctcaaaagc tactaccaaa    900
 aaaaccccac aaatttgcca atccatgaaa gtatcatagg aagtctacct ttccaaggaa    960
 tttggcattg tggccctgct cttgccaaat gctctccagc attgttggta tcaaggtggt   1020
 ctggttgagt aaacttgacc aaacaaaaat taactgtttt ttgcttttct gtttttgttt   1080
 tgctgatcaa aaaagccctt cagggtcttt tgtgcatcca ggaggtcatt gtagatatca   1140
 ataatatagt gcctaagtgc cactttattg ccaagtctag attgatactt ttttcagata   1200
 aaccagcttt ttatgtaaag agtaagggaa aaagttaaat ctttaattct gacctgccat   1260
 aaaatacccc aaagatatta aactgtcttc ccacccaccc cccttcatta actaagacat   1320
 ccttcctggg gtccacttct ttaatcatga aacttgattt tctcaattgg ccagtcttct   1380
 gatctttagt atctctttag ttcagtaatt tttacctacc tacttgattt attttccttt   1440
 aaaaggggaa atgacattta aagaaaaaca aacacccatc attcctcagt cccaacacag   1500
 cagttctttt cactcttgct tgtaactttc aggccttacc cacatgtgtt cctatagagt   1560
 tgcatgtagc taaaattata gtgtgctgcc taactttgtg ctaataacga aggacacaca   1620
 ttatcattgc ctcacagtgg atggcacctg accccatttt tccaaggatt ctattttcca   1680
 gtgaattttt gtcaccgagt taatttccca agtctgatag catgaatgct tatttgtgct   1740
 gtgaaaagca gagcagcctg agtcagcttt ccattttcat aggataatat gtgccaaaaa   1800
 aggtttattt tcttggtaaa atcagaattg tagaattgtg ctatttttaa tttttaaaat   1860
 ttttggttag agcttataga cattactttt atgattattt tgcgtgctaa ataagttaaa   1920
 gggtatgttt tgaactatag cactaattaa tgtgtgtgat cctagtatgt tgatagcttt   1980
 gattttgtga gtggtttact agtcatttat tatgattccc atgaactctg atatgattca   2040
 ttgtggtttt aactcaggtt gaataaaagc atccatttct tttataggaa ggtttgttta   2100
 attctcatgt tctgtgatca tctctttgag aataaaattc agtccctaat agttgaaaag   2160
 aaaaaaaaaa aaa                                                      2173



      <210> 450
      <211> 1533
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1533)
      <223> n = a,t,c or g


      <400> 450
 ggcacgagac aatggaagct gccccgtcca ggttcatgtt cctcttattt ctcctcacgt     60
 gtgagctggc tgcagaagtt gctgcagaag ttgagaaatc ctcagatggt cctggtgctg    120
 cccaggaacc cacgtggctc acagatgtcc cagctgccat ggaattcatt gctgccactg    180
 aggatttaga aataccagca gtgcccatac tccatagcat ggtgcaaaaa ttcccaggcg    240
 tgtcatttgg gatcagcact gattctgagg ttctgacaca ctacaacatc actgggaaca    300
 ccatctgcct ctttcgcctg gtagacaatg aacaactgga tttagaggac gaagacattg    360
 aaagcattga tgccaccaaa ttgagccgtt tcattgagat caacagcctc cacatggtga    420
 cagagtacaa ccctgtgact gtgattgggt tattcaacag cgtaattcag attcatctcc    480
 tcctgataaa tgaacaaggc ctccccagaa gtatgaagag aacatgcaca gataccagaa    540
 ggcagccaag ctcttccagg ggaagattcc tcntttattc ctggtgggac aattggtatg    600
 aaaggaaaat ggggaaggtg atatcatttt tcaaactaaa ggagtctcaa ctgccagctt    660
 tggcaattta ccagactcta ggatgacgag tgggatacac tgcccacagc agaagtttcc    720
 gtagagcatg tgcaaaactt ttgtgatgga ttcctaagtg gaaaattgtt gaaagaaaat    780
 cgtgaatcag aaggaaagac tccaaaggtg gaactctgac ttctccttgg aactacatat    840
 ggccaagtat ctactttatg caaagtaaaa aggcacaact caaatctcag agacactaaa    900
 caacaggatc actaggcctg ccaaccacac acacacgcac gtgcacacac gcacgcacgc    960
 gtgacacaca cacgcgcaca cacacacaca cacacacaga gcttcatttc ctgtcttaaa   1020
 atctcgtttt ctcttcttcc ttcttttaaa tttcatatcc tcactcccta tccaatttcc   1080
 ttcttatcgt gcattcatac tctgtaagcc catctgtaac acaacctaga tcaaggcttt   1140
 aagagactca ctgtgatgcc tctatgaaag agaggcattc ctagagaaag attgttccaa   1200
 tttgtcattt aatatcaagt ttgtatactg cacatgactt acacacaaca tagttcctgc   1260
 tcttttaagg ttacctaagg gttgaaactc taccttcttt cataagcaca tgtccgtctc   1320
 tgactcagga tcaaaaacca aaggatggtt ttaaacacct ttgtgaaatt gtctttttgc   1380
 cagaagttaa aggctgtctc caagtccctg aactcagcag aaatagacca tgtgaaaact   1440
 ccatgcttgg ttagcatctc caactcccta tgtaaatcaa caacctgcat aataaataaa   1500
 aggcaatcat gttataggag aaaaaaaaaa aaa                                1533



      <210> 451
      <211> 1137
      <212> DNA
      <213> Homo sapiens


      <400> 451
 tttttttttt ttgagacaga gtctcactgt gtcacccagg ctggagtgca gtggcgtagt     60
 ctcggctcac tgcaagctcc gcctcccggg ttcacgccgt tctcctgcct cagcctctct    120
 gagaagctgg gactacaggc gcccgccacc acgcccggct aatttttttg tatttttagt    180
 agagacgggg tttcactgtg gtctcgatct cctgacctcg tgatccgccc gccttggcct    240
 cccaaagtgc tgggattaca agcgtgagcc accgcacccg gcctgaaaat attttctaaa    300
 aagataaaaa atatacataa cgatgaaaaa taatacaaat ttaaaaacca atacagtata    360
 acaactattt acatagtgct tacattgtat taggtgttat taagccaatc ttaggagatg    420
 attttagcaa gtatacaggg aggatgtgcc taggttatat gcaaatactg tgccatttta    480
 tatcaggaac ttgagcatct gcagatattg gtatcggagg gcggtcctgg gaaccaagca    540
 tccacggata ctgaggggtg acatttcatg aagtgtagat cattgtattc agagattgta    600
 aatgaaaaaa atatagaaac tatttagttt tggtagattt tttttctgac aatgtgacca    660
 gactgaattt cctcataaag aaaaaatggc gtgccttgtg tctgtgtttc tcttttctct    720
 gaaaggatta atagatctga agctttgggc cactcagagc cttccttgat gctgccagag    780
 tcttcttatt tagattttct gtcttaaacc attggaagca aaaccgtttt cccatgacat    840
 tctggccttg gacagattct gttgtcctcg acgcgtctct ttataaagtg gtaaaagcct    900
 gaaattcagg gcagctctcc atgaggtgct gaagggctct tttcataaga agctaaggca    960
 ctgctgcctg ccccaggtgt cccgctcctc tcagagtcct ccccctacca ggtagtgggt   1020
 agctccattt cagaatgtta acctccagtg aagagctaat gactggttag aagattgaca   1080
 aactaaccaa aattttacac acttccggtt atgtgtgtga aaggttataa aaaggaa      1137



      <210> 452
      <211> 2575
      <212> DNA
      <213> Homo sapiens


      <400> 452
 tttttttttt gttttttgtt cctattgtta ccctctttat tccaaaacaa ttacacattt     60
 caacttttca aaagcaacat ctgggtaagt taggaatatt cacagcttct tacacagtgt    120
 cagagaaaga gactatctga gctcaccagg tatctgctgt gtgttgggga aactgaaaaa    180
 caagcaaaag tataactaca atctggactt ttttcttttt taaataaagt tttttttttc    240
 catttttctt ctcatactgt gaattgttct tgactccttt tcttgacatt cagttttcag    300
 aatttccatc tttcttctgg aactaatgtg ctgttctctt gactgcctgc tgggccagca    360
 tccgattgcc agccagaaac gtcacactgc ccaagatggc caggtacttc aaggtctgga    420
 acatgttgag ctgagtccag tagacataca tgagtcccag catagcagca tgtcccaggt    480
 gaaatataat cgtgctagga gcaaaagtga agttggagac attggcacca atccggatcc    540
 acagagcgaa gagcagaagc aacggcgaga ggatcagggc agtgaatgta ttggacacca    600
 cggtgggggg cctcttctca ggctcgcgga acaggtgctg aatttcctgt tttggagtga    660
 aaaggttctg ggacaagaca gtcgagggag cttcttcctc agggaacttg atgaccacat    720
 cagccacatt ccagaggatt gggttcttca aagtggcatc tccaatgatt aaagtagaaa    780
 gtgtaggtgc cagagcggga agtcaaattc aatcctttcc tttcagaggt atccagttca    840
 aacttgtaca cgttcttgtt gtctggctcg gcaacaaaca ccacttccct ggccagtctt    900
 ctggttatgg agtcggacaa atgtctggtg aggagtgagt tcagcaccag tgttcacacc    960
 tacccagctg gaagaacaag gcgaagttct ggtggctgtc tgcgatgaat gtgcccttgg   1020
 ctttggcctg ggtatgtcac ccgggtagtt tgggggtgca atgctctgat ccttatccca   1080
 cggtggaaag atcaacattt gtgatgccaa cttcagtggg aggatcttgg actctgagct   1140
 ctacggtatt tggaaatata ccggttgtca cctttcaact ttcgaccaag gaagtcatta   1200
 ataaccactt ggaaaatttg acggttcatg aaatttagtt caaaaacaat ccctacaagg   1260
 ggtgaaggat gtcttctgga ggacagtggc tcttggaagc aacagattta gcatgttcta   1320
 gtttaacagt ggcctgagtc agaggctgag acagaacatt ggtgacttgc aaccgcaaga   1380
 tagcctgttc atgagtgtcg gaagcagagc cctcaggcac aaccacaact ggcacgtggt   1440
 agcgattatg cgagagcaca gcagctgcag aggcccacgc tgaaggcttc ggagagggac   1500
 ttcaaagttc ttcttgctga aagatcgcgg ttcatcagct ggatgacctg atccttcctt   1560
 aatggatggc ttcagtcccc acaatgatcc attgagcttt gtaggtggca gccacaaact   1620
 aacgctgttg tttccagtcc ttcttcaaac ttggagatac acgcccccga gttcatccag   1680
 gcgagcaaca aggtcctcaa tctcctccac gatgctcctc aggtcagcct gctgggacag   1740
 gtgggatgct gtctgcagag cctggactgt tgccagcaca gtctcctcct tgctgagacg   1800
 agcagtaagg gcactgagtg cttcttggga tgccaaggga aggcccaaag cccactttag   1860
 agctgccaac ttgcatggta agatctgggg taaacagatg aagtccctca actgaacagc   1920
 tgcccaaaag ccagatcttt ggtcctcatt tgaaaataga gatcttcaca ttcctgagag   1980
 ggccttggct ggccctgggc cagccgtaga agagggaatc ccacattgcc tgggatcaag   2040
 gttagatctt gatgtaggta catgctttct ttgcactctg gcacctgagc acccaaggct   2100
 gctgagtccc acgattggag tagaaggcag attccaaatt tgtgaaaggg cgatccagcg   2160
 aggcttttag tctctccacg tcatgcttgg tgaggtagtg agtgggcgtc agagcccaag   2220
 gtgctggcta tgattgtcat gggccaacat ggaagacacg tgcttgaaac ccggcggcgc   2280
 cattcctccg atgcacggtc ccgccggagt ccgagccgcg ggctgacttc cgctcgggaa   2340
 agtggctcca agagcccgcc acaggggacg ccagggactc gcggcaggct ctgcgggcca   2400
 ggatgagttc taagcacagg tcagtgtccg cggccccgct gagcttcgac gcttccagca   2460
 gccgcggccg ggatcccagt cctcccgctc acagggcctt gcagttcccg aggacagacc   2520
 cgcctctccc ccgcgcccag gcccacttgg aaccgaccgt ctcgcaacgc tggaa        2575



      <210> 453
      <211> 1052
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1052)
      <223> n = a,t,c or g


      <400> 453
 ggttctaggg gagaacctgc ttccttgcct tttccagccc caggggtcac tggcattcat     60
 tggcccggac tccttccccc aaccccaaag ccagcagcac cacatctctc tgacccttca    120
 tccgttgtcc cctctccccc caagccccat gggacagggt ctccactcct gagactcatg    180
 ggattagact aggcctacct ggatgatctg ggatcctctc ccatgtccag gtctctatcc    240
 ctaaccacat cagcaaagtc tcttttgcca tggaaggtat ttgcaggctc tgactttgtg    300
 tgtattaggg caggacattt ttggcggggc agtggtgggg gcagggaatt attctgccta    360
 ccatgcctta tacaaaaata aataaatcac aggcttatac ctgaaagaat tcctgcaaat    420
 aataaaagaa ttagagcagc tcagttaaat aaaaaaaggt atgannnnnn nnnnnnnnnn    480
 nnnnnnnnnn nnnnnngcag gggagcaagg tatttatcaa aaagtgctcc acttttcact    540
 taccagagaa atgcaaatca gcacccaaag gagtcactgc ggcaccctca tctgagcctc    600
 agaagttaga aagatggata gcaccagtgt caaaggtgac tgtgggaggg agatttgcat    660
 acactgctag taacaatgcg aattgatgga accaacctgg aaaatggctt ggcatcaact    720
 gttggagaag aagacacaca gtcctctaac ctgccagtcc cacatcaggg cctggatatg    780
 gccgtcatgt gtaccaggga gcatggccag gaatctttac agccaaatac tcaccatagc    840
 accaaactgg aatcagccga catacccatc aggaagagaa tggatgttaa aaaatgcaag    900
 gatagccatt gggtagaacg ccatacagcc atgacaatta cacagtgaca cctacacaca    960
 aggagcatga gtctcacaaa catggcagca aaaggagcct gttcaagagg gtatgtgcta   1020
 tggattccat tgtagataaa gtttttcaaa ag                                 1052



      <210> 454
      <211> 1460
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1460)
      <223> n = a,t,c or g


      <400> 454
 cggtccggat atcccgactc gaccatttcg tgggcgttcg atccctagag ggaggagcct     60
 gtccaaacgg acgctaacgg cctacctccc cctcaggtgc tcttacagcc tgttccaagt    120
 gtggcttaat ccgtctccac caccagatct ttctccgtgg attcctctgc taagaccgct    180
 gccatgccag tgacggtaac ccgcaccacc atcacaacca ccacgacgtc atcttcgggc    240
 ctggggtccc ccatgatcgt ggggtcccct cgggccctga cacagcccct gggtctcctt    300
 cgcctgctgc agctggtgtc tacctgcgtg gccttctcgc tggtggctag cgtgggcgcc    360
 tggacggggt ccatgggcaa ctggtccatg ttcacctggt gcttctgctt ctccgtgacc    420
 ctgatcatcc tcatcgtgga gctgtgcggg gctccaggcc cgcttccccc tgtcttggcg    480
 caacttcccc atcaccttcg cctgctatgc ggccctcttc tgcctctcgg cctccatcat    540
 ctaccccacc acctatgtcc agttcctgtc ccacggccgt tcgcgggacc acgccatcgc    600
 cgccaccttc ttctcctgca tcgcgtgtgt ggcttacgcc accgaagtgg cctggacccg    660
 ggcccggccc ggcgagatca ctggctatat ggccaccgta cccgggctgc tgaaggtgct    720
 ggagaccttc gttgcctgca tcatcttcgc gttcatcagc gaccccaacc tgtaccagca    780
 ccagccggcc ctggagtggt gcgtggcggt gtacgccatc tgcttcatcc tagcggccat    840
 cgccatcctg ctgaacctgg gggagtgcac caacgtgcta cccatcccct tccccagctt    900
 cctgtcgggg ctggccttgc tgtctgtcct cctctatgcc accgcccttg ttctctggcc    960
 cctctaccag ttcgatgaga agtatggcgg ccagcctcgg cgctcgagag atgtaagctg   1020
 cagccgcagc catgcctact acgtgtgtgc ctgggaccgc cgactggctg tggccatcct   1080
 gacggccatc aacctactgg cgtatgtggc tgacctggtg cactctgccc acctggtttt   1140
 tgtcaaggtc taagactctc ccaagaggct cccgttccct ctccaacctc tttgttcttc   1200
 ttgcccgagt tttctttatg gagtacttct ttcctccgcc tttcctctgt tttcctcttc   1260
 ctgtctcccc tccctcccac ctttttcttt ccttcccaat tccttgcact ctaaccagtt   1320
 cttggatgca tcttcttcct tccctttcct cttgctgttt ccttcctgtg ttgttttgtt   1380
 gcccacatcc tgttttcacc cctgagctgg nnctcttttt cttttcnnnn nnnnnnnnnn   1440
 nnaaaaacgg atcccacctg                                               1460



      <210> 455
      <211> 2442
      <212> DNA
      <213> Homo sapiens


      <400> 455
 ggctgccagc gtttcatgat caacatggga gactcccacg tggacaccag ctccaccgtg     60
 tccgaggcgg tggccgaaga agtatctctt ttcagcatga cggacatgat tctgttttcg    120
 ctcatcgtgg gtctcctaac ctactggttc ctcttcagaa agaaaaaaga agaagtcccc    180
 gagttcacca aaattcagac attgacctcc tctgtcagag agagcagctt tgtggaaaag    240
 atgaagaaaa cggggaggaa catcatcgtg ttctacggct cccagacggg gactgcagag    300
 gagtttgcca accgcctgtc caaggacgcc caccgctacg ggatgcgagg catgtcagcg    360
 gaccctgagg agtatgacct ggccgacctg agcagcctgc cggagatcga caacgccctg    420
 gtggttttct gcatggccac ctacggtgag ggagacccca ccgacaatgc ccaggacttc    480
 tacgactggc tgcaggagac agacgtggat ctctctgggg tcaagttcgc ggtgtttggt    540
 cttgggaaca agacctacga gcacttcaat gccatgggca agtacgtgga caagcggctg    600
 gagcagctcg gcgcccagcg catctttgag ctggggttgg gcgacgacga tgggaacttg    660
 gaggaggact tcatcacctg gcgagagcag ttctggccgg ccgtgtgtga acactttggg    720
 gtggaagcca ctggcgagga gtccagcatt cgccagtacg agcttgtggt ccacaccgac    780
 atagatgcgg ccaaggtgta catgggggag atgggccggc tgaagagcta cgagaaccag    840
 aagcccccct ttgatgccaa gaatccgttc ctggctgcag tcaccaccaa ccggaagctg    900
 aaccagggaa ccgagcgcca cctcatgcac ctggaattgg acatctcgga ctccaaaatc    960
 aggtatgaat ctggggacca cgttggctgt gtacccagcc aacgactctg ctctcgtcaa   1020
 ccagctgggc aaaatcctgg gtgccgacct ggacgtcgtc atgtccctga acaacctgga   1080
 tgaggagtcc aacaagaagc acccattccc gtgccctacg tcctaccgca cggccctcac   1140
 ctactacctg gacatcacca acccgccgcg taccaacgtg ctgtacgagc tggcgcagta   1200
 cgcctcggag ccctcggagc aggagctgct gcgcaagatg gcctcctcct ccggcgaggg   1260
 caaggagctg tacctgagct gggtggtgga ggcccggagg cacatcctgg ccatcctgca   1320
 ggactgcccg tccctgcggc cccccatcga ccacctgtgt gagctgctgc cgcgcctgca   1380
 ggcccgctac tactccatcg cctcatcctc caaggtccac cccaactctg tgcacatctg   1440
 tgcggtggtt gtggagtacg agaccaaggc cggccgcatc aacaagggcg tggccaccaa   1500
 ctggctgcgg gccaaggagc ctgtcgggga gaacggcggc cgtgcgctgg tgcccatgtt   1560
 cgtgcgcaag tcccagttcc gcctgccctt caaggccacc acgcctgtca tcatggtggg   1620
 ccccggcacc ggggtggcac ccttcatagg cttcatccag gagcgggcct ggctgcgaca   1680
 gcagggcaag gaggtggggg agacgctgct gtactacggc tgccgccgct cggatgagga   1740
 ctacctgtac cgggaggagc tggcgcagtt ccacagggac ggtgcgctca cccagctcaa   1800
 cgtggccttc tcccgggagc agtcccacaa ggtctacgtc cagcacctgc taaagcaaga   1860
 ccgagagcac ctgtggaagt tgatcgaagg cggtgcccac atctacgtct gtggggatgc   1920
 acggaacatg gccagggatg tgcagaacac cttctacgac atcgtggctg agctcggggc   1980
 catggagcac gcgcaggcgg tggactacat caagaaactg atgaccaagg gccgctactc   2040
 cctggacgtg tggagctagg ggcctgcctg ccccacccac cccacagact ccggcctgta   2100
 atcagctctc ctggctccct cccgtagtct cctgggtgtg tttggcttgg ccttggcatg   2160
 ggcgcaggcc cagtgacaaa gactcctctg ggcctggggt gcatcctcct cagcccccag   2220
 gccaggtgag gtccaccggc ccctggcagc acagcccagg gcctgcatgg gggcaccggg   2280
 ctccatgcct ctggaggcct ctggccctcg gtggctgcac agaagggctc tttctctctg   2340
 ctgagctggg cccagcccct ccacgtgatt tccagtgagt gtaaataatt ttaaataacc   2400
 tctggccctt ggaataaagt tctgttttct gcaaaaaaaa aa                      2442



      <210> 456
      <211> 2114
      <212> DNA
      <213> Homo sapiens


      <400> 456
 atgtcgcgga ggctgctgcc ccgggcggag aagcggcgtc ggcggctgga gcagaggcag     60
 cagccggacg agcagcggag gcggtcggga gcgatggtga agatggcggc ggcgggcggc    120
 ggaggcggcg gtggccgcta ctacggcggc ggcagtgagg gcggccgggc ccctaagcgg    180
 ctcaagactg acaacgccgg cgaccagcac ggaggcggcg gcggtggcgg tggaggagcc    240
 ggggcggcgg gcggcggcgg cggtggggag aactacgatg acccgcacaa aacccctgcc    300
 tccccagttg tccacatcag gggcctgatt gacggtgtgg tggaagcaga ccttgtggag    360
 gccttgcagg agtttggacc catcagctat gtggtggtaa tgcctaaaaa gagacaagca    420
 ctggtggagt ttgaagatgt gttgggggct tgcaacgcag tgaactacgc agccgacaac    480
 caaatataca ttgctggtca cccagctttt gtcaactact ctaccagcca gaagatctcc    540
 cgccctgggg actcggatga ctcccggagc gtgaacagtg tgcttctctt taccatcctg    600
 aaccccattt attcgatcac cacggatgtt ctttacacta tctgtaatcc ttgtggccct    660
 gtccagagaa ttgtcatttt caggaagaat ggagttcagg cgatggtgga atttgactca    720
 gttcaaagtg cccagcgggc caaggcctct ctcaatgggg ctgatatcta ttctggctgt    780
 tgcactctga agatcgaata cgcaaagcct acacgcttga atgtgttcaa gaatgatcag    840
 gatacttggg actacacaaa ccccaatctc agtggacaag gtgaccctgg cagcaacccc    900
 aacaaacgcc agaggcagcc ccctctcctg ggagatcacc ccgcagaata tggagggccc    960
 cacggtgggt accacagcca ttaccatgat gagggctacg ggcccccccc acctcactac   1020
 gaagggagaa ggatgggtcc accagtgggg ggtcaccgtc ggggcccaag tcgctacggc   1080
 ccccagtatg ggcacccccc acccccttcc cccaccaccc gagtatggcc ctcacgccga   1140
 cagccctgtg ctcatggtct atggcttgga tcaatctaag atgaactgtg accgagtctt   1200
 caatgtcttc tgcttatatg gcaatgtgga gaaggtgaaa ttcatgaaaa gcaagccggg   1260
 ggccgccatg gtggagatgg ctgatggcta cgctgtagac cgggccatta cccacctcaa   1320
 caacaacttc atgtttgggc agaagctgaa tgtctgtgtc tccaagcagc cagccatcat   1380
 gcctggtcag tcatacgggt tggaagacgg gtcttgcagt tacaaagact tcagtgaatc   1440
 ccggaacaat cggttctcca ccccagagca ggcagccaag aaccgcatcc agcaccccag   1500
 caacgtgctg cacttcttca acgccccgct ggaggtgacc gaggagaact tctttgagat   1560
 ctgcgatgag ctgggagtga agcggccatc ttctgtgaaa gtattctcag gcaaaagtga   1620
 gcgcagctcc tctggactgc tggagtggga atccaagagc gatgccctgg agactctggg   1680
 cttcctgaac cattaccaga tgaaaaaccc aaatggtcca tacccttaca ctctgaagtt   1740
 gtgtttctcc actgctcagc acgcctccta attaggtgcc taggaagagt cccatctgag   1800
 caggaagaca tttctctttc ctttatgcca ttttttgttt ttgttatttg caaaagatct   1860
 tggattccct tttttttttt tttttttttt tttaaatgct aggtttgtag aggcttactt   1920
 aaccttaatg gaaacgctgg aaatctgcag ggggagggag aggggaactg ttatctccca   1980
 agattaacct tcacttttaa aaaattattg tacatgtgat tttttttttt tcctgttcat   2040
 acatttgggc tgcccatgta ctcttggcac atttcaataa aattgtttgg aaaataaacc   2100
 cagcaaaaaa aaaa                                                     2114



      <210> 457
      <211> 2248
      <212> DNA
      <213> Homo sapiens


      <400> 457
 ctatccaaag agaacattaa gagtaagacc cagagccttg acagatgctt cagctctaaa     60
 ccagaaccag gaaccacatc catcaactgt ccagttcatc ttccttttcc tttctgcaat    120
 ctgctcctct gattccattt ctacttcatt actaatagga gttttttctt ctatatcatc    180
 aataaaatct ggttcctgat tatttgatac tgatagtctc agtggagaaa gctttctttg    240
 tttagtttct gggctcttca ttttgttggt cgttccttca caatccaaag taatattctg    300
 attttgtgta tctttttctt ttgaaatatc tttgtctttt tttccttttt tccgtctggt    360
 ctcataacca ctattgatat tttccatgga ttcagaacta cgttttagaa cagggcactc    420
 tgggttttct ttgaggcatg cacagtccac cttgtactta caatttccat agtcaaaatc    480
 aaaggcaata gtaatttcag ttccctttgg aatactgtgt atagaataaa tataaagatg    540
 tatggttcca tcttgaattt catgcctcac ctctgcattg ggtgtacaag accgcctgat    600
 gaatcgagcc tcattcccaa aagtccttgc atcaacacac atttctagcc catggaaatt    660
 tagagtagga ataacacaaa agggtatggg tcttttaaaa gaaataccca tttgcttcaa    720
 actgttcttc tcaggcataa acttccctct gtattcaatg ataagtgcat cagggaggcc    780
 aatcttttgg cagatttaag aattttcttt attcttttgt atatggctct ctacaggagg    840
 tttgaagagc aaattgttgg tattcaaatc ggatttattc atctcttttt tgtcatttcc    900
 attgcctaat ctcagagcta ttctttgtgc ctccctctga acaccctcac tgtactggtt    960
 gttatttgct tcttcatatc gatccatcca tgctttgatc tttgtctccc atccaaaatt   1020
 tgaaccatca gatgaaggat caatctctgg agctgaaccc tttttacatt ttgaaatgtg   1080
 ttgttctttc tccccgcttt ttttccttct tttatcatta actttggaaa ctcttgaagc   1140
 agttaaagta attgatgttg gagtatgctg aaatgcagta tataattcca caggaacctc   1200
 atcaccactc tcagttgcac tggtatcacc atctgacata ttttcccttt tccggcgttg   1260
 tagtagcact gccctctctt tatccaaatt cctaggctga caacgttcac atagatatgt   1320
 atcaggaata tgctgcctat caatccccat gcagtcaata tgttgccaaa cgctgcattt   1380
 gtcacaacag atcatgtatc catcatcatg tgtaaaacca catatgcacc tgggttacat   1440
 cagtaccata acttccatcc tcaggatgtg ctgattgtag gtaggcactg ggaagtttca   1500
 tcaaaattag ggagtgggta aatatggcct acttcatttt tgctaataag gactgatggg   1560
 aggaggggga gccggggtgt tcggaggagg gacgagcacc ctattatggg tccgcatagg   1620
 ggcaaaccca ttgtaactgt gtgaatgatg tgagctgctg gtatataact ggtggggata   1680
 actgttggat ttctcaacta ccacagggct agcttctacg gattctggtt ctgaacctgc   1740
 agccatttcc aagtatgacg tctctgctgt atcaaccccc aatgggatca ctatgctcat   1800
 gacgttcgcc tctggtaaat tcgattacta tggagtccta tgcattggta tccaaaacac   1860
 tggggcatgc cagccacagt gctcattgca aacatctaag tgcatccaca aaccctgtga   1920
 tgttcacaca cgagacaccc gaaccccgtt atgtgctcga cccccaagga gtctctccgc   1980
 acctccgcga acaggcgacc ccccgacagc agccactgcg gacacaggac ccggctccac   2040
 acaccccctc cccaaacagc agcgcgcagc ctcttcacca ggaaccgagg agtaggggag   2100
 ggggcagcca ggcagtcaac aggaacgcag agacgacggc gaggctgctc ggagtgtcta   2160
 tgcccactct gttgccgctc ccgaactccg gcacggtctc cgactcggcc ccctgcgccc   2220
 gctcagtgtc actgcctctc gcacgaaa                                      2248



      <210> 458
      <211> 2248
      <212> DNA
      <213> Homo sapiens


      <400> 458
 ctatccaaag agaacattaa gagtaagacc cagagccttg acagatgctt cagctctaaa     60
 ccagaaccag gaaccacatc catcaactgt ccagttcatc ttccttttcc tttctgcaat    120
 ctgctcctct gattccattt ctacttcatt actaatagga gttttttctt ctatatcatc    180
 aataaaatct ggttcctgat tatttgatac tgatagtctc agtggagaaa gctttctttg    240
 tttagtttct gggctcttca ttttgttggt cgttccttca caatccaaag taatattctg    300
 attttgtgta tctttttctt ttgaaatatc tttgtctttt tttccttttt tccgtctggt    360
 ctcataacca ctattgatat tttccatgga ttcagaacta cgttttagaa cagggcactc    420
 tgggttttct ttgaggcatg cacagtccac cttgtactta caatttccat agtcaaaatc    480
 aaaggcaata gtaatttcag ttccctttgg aatactgtgt atagaataaa tataaagatg    540
 tatggttcca tcttgaattt catgcctcac ctctgcattg ggtgtacaag accgcctgat    600
 gaatcgagcc tcattcccaa aagtccttgc atcaacacac atttctagcc catggaaatt    660
 tagagtagga ataacacaaa agggtatggg tcttttaaaa gaaataccca tttgcttcaa    720
 actgttcttc tcaggcataa acttccctct gtattcaatg ataagtgcat cagggaggcc    780
 aatcttttgg cagatttaag aattttcttt attcttttgt atatggctct ctacaggagg    840
 tttgaagagc aaattgttgg tattcaaatc ggatttattc atctcttttt tgtcatttcc    900
 attgcctaat ctcagagcta ttctttgtgc ctccctctga acaccctcac tgtactggtt    960
 gttatttgct tcttcatatc gatccatcca tgctttgatc tttgtctccc atccaaaatt   1020
 tgaaccatca gatgaaggat caatctctgg agctgaaccc tttttacatt ttgaaatgtg   1080
 ttgttctttc tccccgcttt ttttccttct tttatcatta actttggaaa ctcttgaagc   1140
 agttaaagta attgatgttg gagtatgctg aaatgcagta tataattcca caggaacctc   1200
 atcaccactc tcagttgcac tggtatcacc atctgacata ttttcccttt tccggcgttg   1260
 tagtagcact gccctctctt tatccaaatt cctaggctga caacgttcac atagatatgt   1320
 atcaggaata tgctgcctat caatccccat gcagtcaata tgttgccaaa cgctgcattt   1380
 gtcacaacag atcatgtatc catcatcatg tgtaaaacca catatgcacc tgggttacat   1440
 cagtaccata acttccatcc tcaggatgtg ctgattgtag gtaggcactg ggaagtttca   1500
 tcaaaattag ggagtgggta aatatggcct acttcatttt tgctaataag gactgatggg   1560
 aggaggggga gccggggtgt tcggaggagg gacgagcacc ctattatggg tccgcatagg   1620
 ggcaaaccca ttgtaactgt gtgaatgatg tgagctgctg gtatataact ggtggggata   1680
 actgttggat ttctcaacta ccacagggct agcttctacg gattctggtt ctgaacctgc   1740
 agccatttcc aagtatgacg tctctgctgt atcaaccccc aatgggatca ctatgctcat   1800
 gacgttcgcc tctggtaaat tcgattacta tggagtccta tgcattggta tccaaaacac   1860
 tggggcatgc cagccacagt gctcattgca aacatctaag tgcatccaca aaccctgtga   1920
 tgttcacaca cgagacaccc gaaccccgtt atgtgctcga cccccaagga gtctctccgc   1980
 acctccgcga acaggcgacc ccccgacagc agccactgcg gacacaggac ccggctccac   2040
 acaccccctc cccaaacagc agcgcgcagc ctcttcacca ggaaccgagg agtaggggag   2100
 ggggcagcca ggcagtcaac aggaacgcag agacgacggc gaggctgctc ggagtgtcta   2160
 tgcccactct gttgccgctc ccgaactccg gcacggtctc cgactcggcc ccctgcgccc   2220
 gctcagtgtc actgcctctc gcacgaaa                                      2248



      <210> 459
      <211> 2343
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2343)
      <223> n = a,t,c or g


      <400> 459
 tttttttttt ttcaaatttt cagtagtttt attgaaaaat gcctcttttg tttcagaaat     60
 aaataatata aggcagtgaa attcacaatc tgcagttaaa atataaaagc agcaattcta    120
 tgttcatagt cttgcaaatg ttttccaact acttttgata actaagaaat attatattct    180
 gaaaaaagtt catactaaat atacaacaca aacatgcaat tccctctctg cagaataatc    240
 tgcaatttgg tataaatgtt agtgtgtcta aaacaaggag gtttaaggca atatggaact    300
 gtatcccgtt gatgcactaa cttcatctac atggcttaag gtttgtggtt gttaaagaga    360
 tgtatacgag cattctatgc cccggcgtat aacagagata gaagaggaag ataagtaatt    420
 gcaatggagt tgacgtttcc ctcctttttg gttttaggag gggaattatt tgaatcgtgg    480
 tgtaattgaa ttgaaaataa gtatagcaaa agataaactg cccgctcgaa atacacagca    540
 gctctgggtt ccaggactta actgcttaac ctaagagttt cactgaggct gcccgctgtg    600
 ctaactaaag gcacacggca tgttctctct ttgcagcttt tgttaacaaa gtattttgca    660
 agcatttcaa gggcaaaggc aaaaatgtct acagactgcg tgcttggagc taggcttcct    720
 gcagaaacaa ggttctctac aatcagaaag ggtactcctg gatgagcaac gctggaagaa    780
 acacctcaga aaagacgtac actgctctat ctgacctgta aatgagaatt tcaacacctc    840
 ccccaagcct cgcggcgcgg cgcgtgatct ctggttcact gcccgggtcc gtggggcagg    900
 gcgcggccgc cagcgccggt ggggctcagg aggctcctct gcaggctcgt ctgcgccgta    960
 gtcctcgtat tccgctgtcc gctcgggctc caccggcacg atgaagggct cgcgctcagg   1020
 caggtaggcc ccgccctcgg gcacgtaagg ctctgtccga ttcaacatta caattatggc   1080
 atgatttgga aggcacacac acacacacac acacagcaaa aggtaaatca tcccccgcgg   1140
 tgatggcact ccagtcttaa tttcataact ataaatagat aagttacaat gtcccaatta   1200
 tttccagata atttggtgat aatcaaataa tgaaatggcc ctttcttaaa aaaaaacctt   1260
 caaaaatcca gcagtaaaca caatcattgc acaaatactt gggaagggtc agagactggg   1320
 ccaaagaact gtaaacgcag taactaagta ggattttcgc aaatccccaa gtaactgttt   1380
 atgccttcaa actcctcaat tcaaagaaca acttggaaag atgaggaggt gaggggaagt   1440
 ttcattggct cctagaaact gaactcgggg ggtgaaaagc aactatcacc aggtaatata   1500
 cagtacatga catcttctgt ggctgtacct cacacaaact gagttacagc tggtgggtga   1560
 ggaacaccag tgactacagc aaaacaggaa gaaaaggtga ttttaaactt tggtttgaaa   1620
 attgcagtta caaaacccaa atgagaggac acggacaaaa aagtaacaaa aagacagatg   1680
 ccctgaatca gacacatcgc taacaagcaa gagatgagga gattccattt ggtgttattc   1740
 cggcatagag caagcggcag gctttgatgc agaagcttat tgtagaattg ttaagtgatt   1800
 ttagtcgaca ggatcacata caaatcattt acaagccaca attagtttat tatttacata   1860
 agacatttct ctttaaccag gttaattgtt tttcttaaaa tggcatagac tcctctggtt   1920
 agtagtttta ttatgcacct ctttcaaaac tgaggctcct catggctgtg tgttggaact   1980
 tttttaaaat aatgtttttc tacattatta ctgaaatgca tcaggattat aaactgacac   2040
 cactgctttt gtctcattca agttagtaaa aagagtctcc accctccttt gtgatgtcga   2100
 cccggttcgt taaccattat ctgtggtgag atttccatac agactcattt cctaataagc   2160
 acgtgcgcaa acatcttaga aacaggattt tcatgtattc aaactgtaag cagcactggc   2220
 gacttagaaa atgtgttagc cggaacctgg atagctttgc ccgttgtatg ggatgctggc   2280
 acactgagaa gaatcacagt atccaggagg acctgggggt cctcgnatac ctgagctcgt   2340
 gcc                                                                 2343



      <210> 460
      <211> 423
      <212> DNA
      <213> Homo sapiens


      <400> 460
 gtgtccctct gggaaaaagc ttccagagga aggagcaggc agtaattttt gctgttctgc     60
 agcctccgct ggtgatatcg aggcaaacag ggtctgcagt ggacctccag caaacaccag    120
 caggcctgca gaagaggggc ctgactatta taaggaaaac taacaaatag aaagcagtag    180
 cctcaacgtc aacaaaaagg acaaccacac aaaaacccca tctgaaggtc accagcatca    240
 aagaccaaag gtagataaat ccctgaagat gaggaaaaag cagcgcaaaa aggctgaaaa    300
 ttccaaaaac cagaatgcct cttctcctcc aaaggagcac aactcctcgc cagcaaagga    360
 acaaaactga acagagaatg agtttgatga attgacagaa gtaggcttca gaatgtaggt    420
 aat                                                                  423



      <210> 461
      <211> 623
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(623)
      <223> n = a,t,c or g


      <400> 461
 aacacgcatc atgggtccct gatctatgaa atgaacacaa cctctctgag gctggatgat     60
 ctggaggaag ggggcatgga gcaaatttga ggctctgatt gctgagccag cctcctccca    120
 ggcggtttcc ccaggactct cgtaggaaat aaatagccct ttcaagattc ctcagctgcc    180
 tcaccccctg cacatgtgcc tggggtgtgg cctagaaggg agtgatgttc ttactctggt    240
 ggtctgtgct tctgaacaca ggctacatgc acacactgac aactaccaat aaacagacag    300
 gggaaggtct ttcatctcag ccattttctc ttccccccgc ccccccttag atggagtctt    360
 gctctgtcac ccaggttgga gtgcagtggc acaatcagct cactgcaacc cctcctccta    420
 ggttcaagcg attgagtagc tgagattaca gggcatgcat tcantatgcc ggggtttttt    480
 gttatttttt agtaggagat gggggtttta ccatgttggg ccagggttag ttttcaaant    540
 cctggaccta ggtgatggca cccacnttgg gccttcccaa agtgtttngg ggnttacagg    600
 gcntgaggcc accagggnca gcc                                            623



      <210> 462
      <211> 481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(481)
      <223> n = a,t,c or g


      <400> 462
 agggatgccg gggtccgnna actgatgccc ctgnagcgat cgtacggnct caannnatgg     60
 gncgacccac gcgtccgccc acgcgtncgg cacaagaaaa gatgcttaac atatttaacc    120
 attaaataaa tgcaaattaa aaccaagatg agatatcact tcacacactc taggatgttt    180
 atagttaaaa aagatagtaa atgctggcaa atatgtggag aaattgaaat cctcacacac    240
 tgctgttgga aatgtacaat ggtacagtca ctttggaaaa tagtctaacc gttcctcaaa    300
 atgatggaga aaatgaggag tgagttctaa taggtatggg cttcctttgg gggtgatgaa    360
 aatgttctta aattgatcat ggtaatggtt gcacaaccct gtgcatatac taaaacccat    420
 taaattttgt acttaaattg ggtgaattgt ggaataatat tgttaataat atctcaataa    480
 n                                                                    481



      <210> 463
      <211> 1325
      <212> DNA
      <213> Homo sapiens


      <400> 463
 tcccagctgg taacaggttc ttctgggctg ggcagtaccc tgaatttaca aggcgccttc     60
 ctagtttctc accctcagcc cacggcccag ccccaggtct gcctatttgg cagtccggga    120
 cataggccca aaaatggcca gagacacagt gaatctctgg cctcaggcaa gagatccatc    180
 tgagaacgcg tccccagcct gctccagact cacgccgaga aggtcctcgt ccggcgagtg    240
 ggcagtgggc ttgggaccac gttgccgcgc agaggggatg gtgagcgctc acggctccaa    300
 ggggtgtcca gcagcccgac tgaagcttga tgggtggggg gctgtggtgg tgggggaggc    360
 tcagatgaca tggctgacct ggaaagagaa gaggctgtca ggggctcgtg ccttgcaagg    420
 tagggaccct gtgcttaccc ccatgtccac gtctgacagt ccagtatctg aggctcattc    480
 ctctcgggca cctcagcacc attgtcacct tgtctgggag cacgcctggc agggtcagat    540
 gcctactctg ggctcctgaa gcaaccgtgg ggccccctcg atcatagctc ttcatgaaaa    600
 tgccacatcc tcccccatga ccaggatggc atcggtcccc tctgtgtccc cagcacaagg    660
 catggatccc ggcacatttg ggacacatag tatttgtggg agggaaggag gaaggtgagc    720
 agaaaaccca aagccagggg ccgggcgcag tggctcacac ctgcaatccc agcactctgg    780
 gaggcccagg ctggtctcga actcctggcc tcaagagatt cacctgcctt ggcctcctaa    840
 attgatggga ttacaggcgt gagccagcgt gcccggtcag aatatactcc attttcttga    900
 tccattcttc tgtcagtaga cacatgagtt gtttccgtat cttggccatt atgaataatg    960
 cttcagtgaa cacgggggta cagatacctc tttgagatcc tgacttcgtc cttttggcca   1020
 tctacccatg gattaaagac ttaaacacag gacctgaaac tgtaaaactc ctagaaaaaa   1080
 aacataggga aaaagcaatg atattttaga tgtgacacca aaagcacagg caacaaaagc   1140
 aaaacaaaca agttggacaa cgtcaaacta aaaagtgtct gcacagcaag ggaaataatc   1200
 agaatgaaaa agcaacctac agaggggaag agaatatttg caaaccatat atctgataaa   1260
 agggctagta tccaaaatgt ataagaaact ccaacaactc aatggcaaaa aaaaaaaaag   1320
 tcgac                                                               1325



      <210> 464
      <211> 1963
      <212> DNA
      <213> Homo sapiens


      <400> 464
 tttttttttt aataagatat acatatttaa tgattcaagg ggaggagtgc taatgggagt     60
 cgcgtgagtg gtccatgggg ctggggctct gccctagggt tgccatggct gtggggacat    120
 ggatgtggtc tttgtcctgt ggtccccaac tctgggtctt tctcaggact gcctcagtct    180
 cctccttccc aagagcataa cagcgtcgcc cacaccccgt ggggcctctc acggcttctt    240
 ggctttcttc acggaagatg agctggaggc cgactcccgt cgctttctcg aattgggcgt    300
 gaggggtgcg cccaccacat caatgatggt gtccttgggg tcaggaccaa gtccgggttc    360
 agtcactgcc ggctcagcag aggccgggcc tgggcctgat gctggtgtgg cagggccccc    420
 tagcacacca gcccgggcca gtgcctcatg acggtgccgc agcatctgca gctcatactc    480
 gcagttggca caggcctgct tgagctcgta gagcagcacc aggtcgcttc gcagctcatt    540
 gaacatgtgc accagctcct ccgtaggtgt cgggctcagc tccacaccaa gctccagcag    600
 catctgttcc agggccttga tcttcttctg tcccacagag cttggcagct tcatccgttg    660
 gctccgcagc gtgacacctg cagacttgaa gtctggaaac ttgatgcctg cagtctcagg    720
 aacagccggc ttctcagcct cctttttctg gggtagcttc tttttggggg ccttgcgttc    780
 cgtgcgccgc tgctctgcag tggtgtctgc cgctgtgatc agcttctgca ggtcctggct    840
 gcgtttctcc cgctccttct tccgggcctc aatcttgcgc agctcctgta gcaggtactc    900
 ctcctctgcc acctgctctg gggtccggtt gtagagacgc tcaagctgtt ccttccgccg    960
 tcgttcgtgc ccagcatcaa atactggtat cttaaggtct gtgcctggca cagcccgcac   1020
 gttggcaagc ttagcacaga tgtggtagta ccgctccttc aggtcttcca cagaacgctt   1080
 cttgaactgc tggtggtcat accggtcatg gataacaaca aaacgcaggt caaagcggcg   1140
 gctgaggtca aagaggtggt cagtttctgc cttagtccaa gcatcatcgt ggagataaag   1200
 ctggtactcc tgctccgagt acacaggcac ctgcacagtc ttattgaacc tggcaaaggg   1260
 gtagtccttg ccctcctccg ctgcacgtcg ccagtggaag aacattgctc cgtccttgcg   1320
 ggccgggttg gtgaatggca tccacttcca aggccgcacc ttcttggagc ccaacttggc   1380
 cttcactgta cggtatccct ggccagtgtc actgggtagc agtgggggtg catccttctt   1440
 gtcagagtag agcaaggcat agacttcccg gtgcatgccc tcgggcctct tgaaagtcag   1500
 tgtctcagag gacttcttgg attttttctt gtccgggttg ataatgtcct tcttgctgat   1560
 ggtcccagag gctgcatccc cttctggacc cccgagttct agaatgtccc gtacatccgc   1620
 gcccgtagcc atcgcgcctg agagatgggg gagccaccgg aggtcaaggg tcagtgcctg   1680
 aagaaggacc aggctcaggt cagggggcgg ggccaatcca gacctaagcg gaggcgagtt   1740
 gaaggggcgg gccaagagga gaagggtggt ccaggtcagg tcggggatct gcctgtgccc   1800
 ctccgcttgg atgttcctaa cggccccttc agccacctgg gccctcgcac ttccgcacct   1860
 gggtccggca gctgcagccc ccactaccac tcccccacgc gtccgcggac gcgtgggtcg   1920
 cgccgggaat cagcgccgtc aaacgggctc aaaaccccat ttc                     1963



      <210> 465
      <211> 1963
      <212> DNA
      <213> Homo sapiens


      <400> 465
 tttttttttt aataagatat acatatttaa tgattcaagg ggaggagtgc taatgggagt     60
 cgcgtgagtg gtccatgggg ctggggctct gccctagggt tgccatggct gtggggacat    120
 ggatgtggtc tttgtcctgt ggtccccaac tctgggtctt tctcaggact gcctcagtct    180
 cctccttccc aagagcataa cagcgtcgcc cacaccccgt ggggcctctc acggcttctt    240
 ggctttcttc acggaagatg agctggaggc cgactcccgt cgctttctcg aattgggcgt    300
 gaggggtgcg cccaccacat caatgatggt gtccttgggg tcaggaccaa gtccgggttc    360
 agtcactgcc ggctcagcag aggccgggcc tgggcctgat gctggtgtgg cagggccccc    420
 tagcacacca gcccgggcca gtgcctcatg acggtgccgc agcatctgca gctcatactc    480
 gcagttggca caggcctgct tgagctcgta gagcagcacc aggtcgcttc gcagctcatt    540
 gaacatgtgc accagctcct ccgtaggtgt cgggctcagc tccacaccaa gctccagcag    600
 catctgttcc agggccttga tcttcttctg tcccacagag cttggcagct tcatccgttg    660
 gctccgcagc gtgacacctg cagacttgaa gtctggaaac ttgatgcctg cagtctcagg    720
 aacagccggc ttctcagcct cctttttctg gggtagcttc tttttggggg ccttgcgttc    780
 cgtgcgccgc tgctctgcag tggtgtctgc cgctgtgatc agcttctgca ggtcctggct    840
 gcgtttctcc cgctccttct tccgggcctc aatcttgcgc agctcctgta gcaggtactc    900
 ctcctctgcc acctgctctg gggtccggtt gtagagacgc tcaagctgtt ccttccgccg    960
 tcgttcgtgc ccagcatcaa atactggtat cttaaggtct gtgcctggca cagcccgcac   1020
 gttggcaagc ttagcacaga tgtggtagta ccgctccttc aggtcttcca cagaacgctt   1080
 cttgaactgc tggtggtcat accggtcatg gataacaaca aaacgcaggt caaagcggcg   1140
 gctgaggtca aagaggtggt cagtttctgc cttagtccaa gcatcatcgt ggagataaag   1200
 ctggtactcc tgctccgagt acacaggcac ctgcacagtc ttattgaacc tggcaaaggg   1260
 gtagtccttg ccctcctccg ctgcacgtcg ccagtggaag aacattgctc cgtccttgcg   1320
 ggccgggttg gtgaatggca tccacttcca aggccgcacc ttcttggagc ccaacttggc   1380
 cttcactgta cggtatccct ggccagtgtc actgggtagc agtgggggtg catccttctt   1440
 gtcagagtag agcaaggcat agacttcccg gtgcatgccc tcgggcctct tgaaagtcag   1500
 tgtctcagag gacttcttgg attttttctt gtccgggttg ataatgtcct tcttgctgat   1560
 ggtcccagag gctgcatccc cttctggacc cccgagttct agaatgtccc gtacatccgc   1620
 gcccgtagcc atcgcgcctg agagatgggg gagccaccgg aggtcaaggg tcagtgcctg   1680
 aagaaggacc aggctcaggt cagggggcgg ggccaatcca gacctaagcg gaggcgagtt   1740
 gaaggggcgg gccaagagga gaagggtggt ccaggtcagg tcggggatct gcctgtgccc   1800
 ctccgcttgg atgttcctaa cggccccttc agccacctgg gccctcgcac ttccgcacct   1860
 gggtccggca gctgcagccc ccactaccac tcccccacgc gtccgcggac gcgtgggtcg   1920
 cgccgggaat cagcgccgtc aaacgggctc aaaaccccat ttc                     1963



      <210> 466
      <211> 2537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2537)
      <223> n = a,t,c or g


      <400> 466
 ttcgtgaaaa ggctaaggcg tatgtcacct gcctacttta ggaatgcttg aggtccggta     60
 ctgtgggggt ctaagggtct ggttaaaagt ctaaaagcac taagctgggt acgcggacaa    120
 tacagctaaa atcttccctg tcctctagtg gtacgcggat ctgacgcctg acgtaattgt    180
 gtagacgcca ttttagccgg tcagacaagc actggacgtg gcggccattt tgttttggac    240
 accgagcagg agctggcggc cgctgcagac gaaaggcagg aaagggcagg ccgggtgagc    300
 agacggatcg gccgactaga cagccaacca gcaacaacga actgagctcg catactaccg    360
 cttacgcatc taaccaaccg cccatctagc taacccgagc ccctccaccg tcaactcagg    420
 ttcggccggt ccccggcccg cctgccggag ccgtggtggc agccccggga ggagcactgg    480
 cgtctgtttc cttcgattct cgggattcga agatggctgc acagtcagcg ccgaaagttg    540
 tgctaaaaag caccaccaag atgtctctaa atgagcgctt tactaatatg ctgaagaaca    600
 aacagccgac gccagtgaat attcgggctt cgatgcagca acaacagcag ctagccagtg    660
 ccagaaacag aagactggcc cagcagatgg agaatagacc ctctgtccag gcagcattaa    720
 aacttaagca gagcttaaag cagcgcctgg gtaagagtaa catccaggca cggttaggcc    780
 gacccatagg ggccctggcc aggggagcaa tcggaggacg aggcctaccc ataatccaga    840
 gaggcttgcc cagaggagga ctacgtgggg gacgtgccac cagaacccta cttaggggcg    900
 ggatgtcact ccgaggtcaa aacctgctcc gaggtggacg agccgtagct ccccgaatgg    960
 gcttaagaag aggtggtgtt cgaggtcgtg gaggtcctgg gagagggggc ctagggcgtg   1020
 gagctatggg tcgtggcgga atcggtggta gaggtcgggg tatgataggt cggggaagag   1080
 ggggctttgg aggccgaggc cgaggccgtg gacgagggag aggtgccctt gctcgccctg   1140
 tattgaccaa ggagcagctg gacaaccaat tggatgcata tatgtcgaaa acaaaaggac   1200
 acctggatgc tgagttggat gcctacatgg cgcagacaga tcccgaaacc aatgattgaa   1260
 gcctgcccat cctcccatga gagactcttg ttagtcaaca catctgtaaa taaccttgag   1320
 ataacagatg agaagaaatc tgattgatgc tggatggacc tatcacaata ggctgtggac   1380
 ttacttgcca ccagcttgtg catttagtgt gttcctttta ctttttgata ctgtgttgta   1440
 tgaaaccctt ttgtcctttg atttggtttt ttgtttttgt ttttttaggg gggagggggg   1500
 gtttcccctc ctttgcccag acttctcttt gaacacaaat gcattagcct tgtggctaga   1560
 acaccctctt cctacctctg tctcccctca cttgtcatat gctctgacat gctaacattt   1620
 cttttgttca tccctgttgc ccccacagaa acatcccaga aaaaccggtc agtgttcctt   1680
 cctccctgat ccttaggttt ctgaaatagg gttctgttac atcctcttcg atagcctgtt   1740
 taaaatgttt agaaggtctg gagctcaaaa atgcgttctt ccacattgat aatttagtaa   1800
 actgagaaca ttgacatcac tacagggcag cataagaggt tgcttacatg tggtagcagc   1860
 tctggtttga ttcaagttgc taccatgtac attgacagca catataccat aaccagcgtg   1920
 ttgggttgaa ttgcactttc tacctttgta tgagatttac agactttcct tctgggtttg   1980
 tatcatgacc agaggggtac tatagggttg gtttatactg caatatagag gatcagaagc   2040
 catttgattt ggtaggtgtg tcagaaggga gaatgatggc agacgaactg ctggaagagg   2100
 tcagaagata gccatgctaa aatgcaatta tatcctcatg tttatcccaa actaatcttg   2160
 gacttttcca ctcattagct ttgttttgcc cttgtttccc ttgaaggttt aagttcaacc   2220
 atattctgtc aactgttcag tttcagtgga atcttgtatt tctggttcat tataacaaac   2280
 tgttcgctta aatccaccca ggactctctt tatttgaggt gcctcaaaat gccatggcta   2340
 ctttaatgat gnnnnnnnnn nnnnnnnnng aaaccaagtt tccttcctgt ccccaggttg   2400
 aagggcaggg gcgcaatttt ggttttcaac cctccacttt tttggttaaa gcaattttcc   2460
 tgcccaaccc ccccgggggg ttggaactac agaatggggn nnnnnnnnnn acttattttt   2520
 ggttttttta gaaaaag                                                  2537



      <210> 467
      <211> 1857
      <212> DNA
      <213> Homo sapiens


      <400> 467
 tttttttttt ttagatttct catagattta tttctgcgtc atattatata tagatatatg     60
 catatatacc tttttttttt taatacaatc tatataccct tcccttcccc accaaactca    120
 caaaaggaga ttaaaccctt ccaggattgc catcaagctt cccgagatgg ccagggccaa    180
 gaaagaatca tctctcaaca tgttaagaaa cggctgccat tcttaggctc tggggttgaa    240
 gcagcagcat tcccaggacc caagggccag agagaggaaa agaaatgact gtagtgtgac    300
 aggattctag gatgaacatg tccagtgact cctggcatgg cagactggct cccagaattc    360
 tcagggtgtg agtaaaggtg ggggccctat ggctcttcag aggctgctca ataggtcagg    420
 ggtagggtat aggaactggg gatcaggcat gcagggatgg ggtggcagaa aaaacgcctg    480
 tgggttatgc tccagacaga gcgaccccca tcagggctac ccacctactc aatgacatgt    540
 aatgaacagg gacagatgct gagctcttaa ggaaacaagg gagagagcat ggcagcgggg    600
 agcaatggaa cacatgaagt cacaaaaaac agaaagtacc aacaaaaaca tgacctacat    660
 ttgactcctc cctagagaag gtgtgatcta tgtttggggt taggggaggt gaagggtcat    720
 gaacctagga ttatcagctg gccaggggca cagaaggctc tctgaggact cctaagaggc    780
 aggcaggcag ctgggacccc acatccccag ggaggaaacg acagttcttt caattcgact    840
 tggaccaaat cttggcgctc cctcggagcc ccttgccctt tgaggctttc ttgctgggct    900
 ggcgctggtt ggtgccagga gctggttccc tcagctcagt caggtgttgc tcagggtcct    960
 gagatgtggc tgcggctgct gctgccgtcg taactttaat ggttttttta aggttggcaa   1020
 cctcactctc aatctgctgc ttcaggccca gctgctgctc cttgtgttgg ttggcacggc   1080
 tcacctgctc ctcaatgcct gacagcacga cctcacagcc cacacaccat tcctgcaggg   1140
 ttcgggcaat ggcactgagg tcctggcgct ggatgtcccg cccgatgctg tagtcaacct   1200
 cgagccgctg gttgcgctgg tccagggagc cacgaagcac gtcagcatac acagcctcaa   1260
 tcacaaggtc ttccagctgc cgcacattac gcagggcaag agcctccagc aacactgcat   1320
 atgggataca ctttacttta gcagccaggg tgacaactga gaggtgtcga agcttattct   1380
 tctgagcctc tgttagtgga ggaagattcc gggcttcagc taagtagtca gcgtatgtcc   1440
 cataagcaaa cactgtgagc agccggaagg tagaggcaaa gtcactctca gccagctctc   1500
 taacattggg catgtccagc agttctccaa acacgtagac accaggggcc tccagcacct   1560
 gatggatgag tgtggccagc gctgccccct tggccgactt ggctaggagc agaaattgct   1620
 cctggttctg ccctgtcacc ttcacttccg cactcatcac tgcactgagt gtgggggact   1680
 tgggctcagg atgtccagag cctgggtcag gctctgcggg ccgctacctg gaagcttcga   1740
 cctccagcgc accgggcggg gccgccgctc cgtcacctcc ggcagctgtt ccaagccttt   1800
 cctgccacct ccctgaagag tcgctctggc cactaaacac gaaatcgtcg acccggg      1857



      <210> 468
      <211> 691
      <212> DNA
      <213> Homo sapiens


      <400> 468
 gcggtggaat tcgcgggacc caaccgcggc gaccggacgt gcactcctcc agtagcggct     60
 gcacgtcgtg ccaatggccc gctatgagga ggtgagcgtg tccggcttcg aggagttcca    120
 ccgggccgtg gaacagcaca atggcaagac cattttcgcc tactttacgg gttctaagga    180
 cgccgggggg aaaagctggt gccccgactg cgtgcaggct gaaccagtcg tacgagaggg    240
 gctgaagcac attagtgaag gatgtgtgtt catctactgc caagtaggag aaaagcctta    300
 ttggaaagat ccaaataatg acttcagaaa aaacttgaaa gtaacagcag tgcctacact    360
 acttaagtat ggaacacctc aaaaactggt agaatctgag tgtcttcagg ccaacctggt    420
 ggaaatgttg ttctctgaag attaagattt taggatggca atcatgtctt gatgtcctga    480
 tttgttctag tatcaataaa ctgtatactt gctttgaatt catgttagca ataaatgatg    540
 ttaaaaaaac tggcatgtgt ctaaacaata gagtgctatt aaaatgccca tgaaccttta    600
 gtttgcctgt aatacatgga tatttttaag atataaagaa gtcttcagaa atagcagtaa    660
 aggctcaaag gaacgtattc ttgaaggtga c                                   691



      <210> 469
      <211> 332
      <212> DNA
      <213> Homo sapiens


      <400> 469
 ccagctctcc catttctgtg tataccaaaa tccacgcata ctcaagtttt caaagtcagt     60
 cctgtggaat ccacatataa cacaaatggg aaaattagtg aggtgtggtg acaagcacct    120
 gtagtcccag ctacttgtga ggccgaggca ggaggatcgc ccgagcccag gaggttgagg    180
 ctgcagcgag ccataactgc accactacac tccagtctgg gcaacagagt gagacagaag    240
 gttgactttt taatagaatt tttctgttca cttgaagata tggtcaggat tgtggcatat    300
 gaaaattctt cataaaataa ctatctaatc ca                                  332



      <210> 470
      <211> 500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(500)
      <223> n = a,t,c or g


      <400> 470
 gggacaaaan ttttgagttc agatgagcct cggaaaancg cgnngaccca cgcgtccgaa     60
 cgagagagtg ggactcatta aattatgaga atcatattta cctaatgccc ttcatttaca    120
 taaatattat actagggggt accatctcac ttctaggaag actagtatat cgctcacacc    180
 tcatatcctc cctactatgc ctagaaggaa taatactatc gctgttcatt atagctactc    240
 tcataaccct caacacccac tccctcttaa ccaatattgg gcctattgcc atactagtct    300
 ttgccgcctg cgaagcagcg gggggcctat ccctactagg ctcaatctcc aacacatatg    360
 gcctaaacta cgtacataac ctaaacctac tccaatgcta aaactaatcg tcccaacaat    420
 tatattacta ccactgacat gactttccaa gaaacacata ttttgaatca acacagccac    480
 ccacagccta attattaagg                                                500



      <210> 471
      <211> 3827
      <212> DNA
      <213> Homo sapiens


      <400> 471
 tttttttttt ttaggattat tctattttta tataagtcaa aagtgagcaa aaatgtaaac     60
 acaatattgt tatacacata acttggtaaa ataattcatt aaaaggacag agggagaatt    120
 accatacgtc aggatagtta gctctggggg aaacagtgag tgtcaagagg ggacacacag    180
 agattttgga gtgctggcaa gacctcctct gcatctagtt tgtgattaca cagctgttgc    240
 tttacccatt aagctctgtt ttaagtactt atttgtaagt tatatttcac aaaatttaaa    300
 agaacaaggg agaacctgtg tactaccaaa tattaacacc aattaaagcg ataattattg    360
 acagtgtaga aaaaacccag aaggcccaga aattggccta agacacaaaa gacacataag    420
 aatttaatat tctataaaaa tagcattact aatcagaggg gaaatggtgg tttcacatac    480
 tgaaccaatt ggtaaattct tcgaaataaa atcaaatccc taccttatat aatataacca    540
 aatacatttg agatggatta aaaatttcct tttcacccca aacttgtact gatttagtta    600
 atgtatataa acaaaattta aattcctttt aaagataggt gtaaaagtga aataagaaaa    660
 tactagaaga aaataaggac atttatccat tcttggatta caaaaatact ttcaagcaca    720
 tacacaaagg tagactccta aagaaaacaa cttctatact gaaataccac aaactatgtt    780
 aaatgacaaa taaggctaaa aaaagttaca atatatgaca aaggacggac attcttaaga    840
 acttatatgc caaaaaaaga gcaaattctc caagcaagca acagaaaaaa tatgaatgag    900
 caattctcaa aagaatgaat atagcatggc caatgaatat gaaaaaaaac acaaccttca    960
 ctaagtaaga aaaacaaata caaattttaa atgtagccct tttctgtaat tattcaattt   1020
 gcaaagattt taagtagtaa ttttcaattc tgagcattgg atatattgct aatgggaatg   1080
 taaatgaaca tgatctctgc agtgagtaat atatataaaa attctcaaaa acactttcac   1140
 ctaacaattt catttttaga gcggtatctt ctggaaataa gtcattttct atggatgtga   1200
 ttaagatgtt aatcatatca ctatttacag attacattat aatacataat caaattgctg   1260
 aataggaaat aaatcttaaa gttatggtat acccatgaaa taaaatatcc tacagctgtc   1320
 taaaaagcaa aatatttaat atgggaacat attgacaata tatagagcag actacaaagc   1380
 aatgtacatt atgatttcat ttttgagaat ataaatgcat aactatgcat agaaaaataa   1440
 gcaaaaacac aacatcaaaa tgttaacaga gtttatctcc ctagatggca ggattacagg   1500
 gaactgtgtg tccaggcaca tgaactcttc catatcatcc agcttccaga aataacatca   1560
 aatttttacg ctgtgaaatc atttactatt cgttttaagg aactaaaact aatgaggaat   1620
 cttagggtca gtatactttt cacatttgct tgaggggggg taaggaatga aaggcaataa   1680
 ttacacctgg aagcaaatgt gaacagtctt tttcgaaagg aaaaagttgt atttaattaa   1740
 gtcccggtaa aacatcacct tagcatttga agttgttcta attaatattt tattcttcaa   1800
 cacttttaaa gactccaata tattagacaa agaatttttt gataatgtaa gttaatttct   1860
 ctggagacaa ccatataatc ctctaaaatg acatgaacgt ttatatatgg gactgaagct   1920
 tctgcagtct atatatacct atttgggggg aaaaaagtaa agtactgaca attcaatttt   1980
 aacaaaaaaa aaatgctttc cttatcaaac attaatgttg tgtacatgaa cctatcatct   2040
 gtgacagcaa ggaactcaag ccaggtgatg cacaagcctt cacccagctc agttagcttg   2100
 ggcttctcct gtaccagatt tgcctgaagt aacatgaggt tatttaaaaa gacctccacc   2160
 tagattgcag tgagccgaga tccctgccac tgcactccag cctgggcgac agagcaagac   2220
 tccatctcaa aaaaaaacac aaaaccaaac aaacaaacca acaaaaaaaa cctccacttt   2280
 ccagcatcta ctcaaaaggg aagtccttcc ctaatccaga agagagataa cgttccttcc   2340
 ctaagggaag acagaaaaag gagaagagca tttgttaagc attctcccat acatgtcttc   2400
 cctaggtatt tcacatccaa tgtctcaata accccatgca aacatgcata caattcttta   2460
 gactgctccc ttcattaccc aaaaaagaag ggaactatgt cttcctaatt gattttaggt   2520
 gcctggaaca actaagtatt tcactgaaag acatgtaata aatgctattt gataggtaaa   2580
 aaaaaggaaa aaagcaaagt tacctctttt catttggctt aaagaaaaaa aaagtatgtt   2640
 ctactatata ctaaaatatc agaccaatac acaatatatt gcaaaatttt aataccatgt   2700
 ggttaaacac aatattcaaa tattaaactt ttcaagcaca tgaaagtcac cttctgaaag   2760
 acaaactggg ctttttttat aactaccttt gtgtaacttt ataaaattac ttccctcaac   2820
 aatatctgac actgatcttg atactagtta gaaagtctga tgtaagatga tgacatctca   2880
 acgtcagtga tttaggagat tatcttcaga attcatcaga ggaccaatcg tcatcttcat   2940
 cccttacttc tcggtatctc cctgaagact ccccttctgg attataactc cgcattttaa   3000
 tattcagtct ttcagctaat ttttgcgctg cgagctttgc ttgcatctcc tcataattct   3060
 gtttctgctg tttctgaagt gccaaggatt cttctatgga gagcagctgc gtgggcatat   3120
 ggtgaagtgg tagaagccga gctgctgtga tgtcatcaag atgctgctta tccctgcgcc   3180
 gccgctcttc tgaggaaata ggagacccac tcttctggca atgactagat gaatcatttt   3240
 gtcgaaaagg taacacattg gttttaaatt tacgcagctg gggcactggg tttttggctc   3300
 gcatttctag cacttccatg taatgaggtt tcttctcagt cccactggaa aggcctgtca   3360
 agttcttagt acttgcgttt tcttctgact gttgttcacc ttggtccgca atggtgatcc   3420
 tctgtaacct gtcaataaac aggttgtcaa agctgctgga agtatcttcc gcttgacttg   3480
 aaacacgatg ccgcgggtga tgctcactag cttcagatga aggtggtacc ctgtctctat   3540
 tgctggaagc tgggccctta ttcactgtgt actcaacctc tgaagtctct tcatcacctt   3600
 caagagtagg acgtccaagt ccctggtttt gtgaggtttg agatgacttg atgttatcta   3660
 cagaggaaca tccaggaact agtgatgaag tatcaagtat cgggtcagaa ttctgggcct   3720
 tatctgtacc cacatcaact tctgcaattg ctttttgcct tagcttacag tctaaactaa   3780
 cagggttaaa cagttcactt tttcttctaa cttcttcaca ttctgcc                 3827



      <210> 472
      <211> 2531
      <212> DNA
      <213> Homo sapiens


      <400> 472
 cgcggccgta cttaggtttg ctcaaaatgg cagcgctgga ggaagaattc acgttgtctt     60
 cggtagtcct gagcgccggg cctgaaggac tcctaggcgt ggagcagagc gacaaaacag    120
 accagtttct agtgacagac agcggcagga cagtcatcct ctataaggtt tctgatcaga    180
 aacccttggg gagctggtca gtgaaacaag gtcaaattat aacatgtcca gctgtgtgca    240
 actttcaaac tggagagtat gttgttgtac acgataataa ggttttaaga atatggaata    300
 atgaagatgt aaacctggat aaagtattta aagctacatt gtcagcagaa gtatatagga    360
 tactttcagt gcaagggaca gaacccttgg tgctcttcaa ggaaggtgct gttcgtggtt    420
 tagaggcctt gcttgcagac ccccagcaga aaattgaaac tgttatctct gatgaagaag    480
 tgattaaatg gacaaagttt ttcgtagtat tcagacatcc tgttttaatt tttattactg    540
 aaaaacatgg aaattacttt gcttacgtgc aaatgtttaa ctcacgtatc ttaaccaaat    600
 atacactctt acttggacaa gacgaaaact ctgttataaa gagttttact gcatctgtag    660
 atcggaaatt catctctttg atgtcattaa gctctgatgg ttgtatatat gaaaccttga    720
 taccaatacg tccagctgac ccagaaaaaa atcagagctt agttaaatca ctgctgctca    780
 aggctgttgt atctggtaac gctcgaaatg gagttgcact cactgccctg gatcaggatc    840
 acgtcgcagt cctaggaagt ccactagcag cttctaagga atgcctctct gtatggaaca    900
 taaaatttca aacactacag acttcaaaag agttaccaca agggaccagt ggtcaactct    960
 ggtattatgg agaacatttg tttatgctac atggaaaatc tctaactgtg attccataca   1020
 agtgtgaagt gtcatcatta gcaggtgctc ttggaaaact caagcatagt caagatccag   1080
 gaactcatgt cgtgtcccat tttgtaaact gggagacacc tcaaggatgt ggacttgggt   1140
 tccagaactc agagcagtca agaagaattt taaggagacg aaaaattgaa gtgagtttac   1200
 agccagaggt tccaccatcc aaacaacttt tgtcaaccat aatgaaagat tcagaaaaac   1260
 acattgaagt agaagtacgg aaatttttgg ctctgaagca gacacctgac tttcatactg   1320
 tcattgggga cacagtaaca ggacttctgg aaaggtgtaa agcagaacca tcattttatc   1380
 cccggaactg tctgatgcag cttatccaaa cgcatgtgct ttcttacagt ttgtgccccg   1440
 acttaatgga gattgcctta aaaaagaaag atgtacagtt gttacaactc tgtctacagc   1500
 agttccctga cattcctgaa tcagtcacct gtgcttgctt aaaaattttc ttgagcattg   1560
 gtgatgacag tcttcaagaa acagatgtta atatggagtc agtttttgac tatagtataa   1620
 attctgtaca tgatgagaaa atggaagagc aaactgaaat tcttcaaaat ggcttcaatc   1680
 ctgaagaaga taaatgcaat aactgtgatc aagagttaaa taaaaagccc caggacgaaa   1740
 caaaggagag cacttcatgc cctgtggtac aaaaaagagc agctctactt aatgcaattc   1800
 ttcattcagc atatagcgag acatttcttc tgcctcattt gaaagacatc ccagcacagc   1860
 atatcacgct gtttcttaag tatttgtatt tcctgtacct gaagtgtagc gaaaatgcta   1920
 ctatgactct tcctggaata cacccaccta ccttgaacca gattatggat tggatatgtc   1980
 tacttctgga tgcaaatttt actgttgttg taatgatgcc agaagcaaag aggctactga   2040
 taaatcttta caagcttgta aaatctcaga tatctgttta ttctgagctc aacaagattg   2100
 aagtaagttt tcgggagcta cagaaattaa atcaagaaaa gaataataga ggattatatt   2160
 caattgaagt gctggagctc ttctgatatt atcaattctc cttcatagac attttataaa   2220
 gctcttttat gtgaactctt gcttcatcca ggcaagaacg gtgttttgtt tgcgaccatc   2280
 tcagtgtcaa gagaaacgtg tcagtgagta cctggaccat cacttaactg atgctccggg   2340
 gtaggactgc aggtttcaca tgaacctgtt ctaggctgtg gacattggtg tggagaggtt   2400
 ctgcaatttt ttaaaaatat gtaactgggt tgattttaag taaaattatt tgtgtattga   2460
 taaaagtcta atttcttatc atgtgttttg aattttttct tttaataaaa aatgaccatt   2520
 gaagcagtga a                                                        2531



      <210> 473
      <211> 548
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(548)
      <223> n = a,t,c or g


      <400> 473
 gggatggggc cnngnnnnaa ctgtgactga cggtgctgac ggtcccgctg ctctgaaggc     60
 ggtgtatgac atggcccgca agggtgcccg tgatgaaatt cagacacana nncntgatgg    120
 tggcctgttc tccggaggtg gacgatgaag accttccgct ggaaagtgaa acccggtatg    180
 gatgtggctt cggtcccttc tgtaagaaag gtgcgctttg gtgatggcta ttctcagcga    240
 gcgcctgccg ggctgaatgc caacctgaaa acgtacagcg tgacgctttc tgtcccccgt    300
 gaggaggcca cggtactgga gtcgtttctg gaagagcacg ggggctggaa atcctttctg    360
 tggacgccgc cttatgagtg gcggcagata aaggtgacct gcgcaaaatg gtcgtcgcgg    420
 gtcagtatgc tgcgtgttga gttcagcgca gagtttgaac aggtggtgaa ctgatgcagg    480
 atatccggca ggaaacactg aatgaatgca cccgtgcgga gcagtcggcc agcgtggtgc    540
 tctgggaa                                                             548



      <210> 474
      <211> 1587
      <212> DNA
      <213> Homo sapiens


      <400> 474
 gttgacggct gcgactccat tttgtaggcc gcttatttgt gtgcatccac ggcgattctt     60
 cccgcagagt tgtgaagcga aaggcttaca attaaaagga agaaaaaaaa ataaagataa    120
 ttcgggagta caattgacaa agcgtgtggg tcgctcagcc tccagcagta actgctgatc    180
 tccagttctt ggagggttcc ggtgagaaga acgcccctac tgcggtactg aggaagcggc    240
 aggaggagat gcggcccctg gacatagacg aggtggaagc gcctgaggaa gtggaggtgc    300
 tggagcccga ggaggatttc gagcagttcc tgctcccggt catcaacgag atgcgcgagg    360
 acatcgcgtc tcttatacgc gagcacgggc gggcgtacct gcggaccagg agcaagctgt    420
 gggagatgga caatatgctt atccagatca aaacgcaggt ggaggcctcg gaggagagcg    480
 ccctcaatca cgtgcagcac ccgagtggcg aagccgacga gagagtgtcg gagttgtgcg    540
 agaaggctga ggagaaagcc aaggagattg cgaagatggc agagatgctg gtcgagctcg    600
 tctggcgaat agagagaagc gagtcttctt gaaggaggag atcggtggtt cacagctgag    660
 gactgtagtc aactggtaag gatgaactga caccttgagg aaactgaaac agcttgtcat    720
 tttctctgtt ttgtttttgt atgtttttta cccccatgta acagtctccc ttatggtcag    780
 tgattgatga cctcgatatg gatttagatt atcaaatgtg tttggttttg gaaatataac    840
 ttttgtcaaa gaaatactct cagaagagaa atggggctta attaagttgt ttttgtggtc    900
 acgtttattc ttgttacttc gctgtgtttt tgaaatgttg ggcatggcct cgtattttgc    960
 tgttaccttt gtgacctgat tgttttttgg aacacgtcaa gacgtgggat cagaatcttc   1020
 caactttaga ggtgcaatgg aagacactac gctacttggt tgagcctggt gaagaatgta   1080
 ttaatgagac tgctttgcat aaaactggga agaaagagaa gacagttgga gatggaagat   1140
 ggttttgtat atattttgga actttagttc ctctgtgaga cgaaagagga gagctatgtt   1200
 ttgtgtcaca ttgtctgata tatattgtgt aacctgtcag gtgagttgat ttagacaaca   1260
 tagctgacct tttatgacaa ggcagtttga atagggacta ttgtaatacc ctcacacatt   1320
 ataggggcat cagagaatgg catggaagag acagtctaca gagagcttta agaggccgga   1380
 gaaaggaaaa gacattatca gggcctggaa agtctcttcc agttcatcag ggtagtagac   1440
 ctgtcagatt ggaggtcaaa gtcaaaagta taataagtgt taatttgcct tgaaaaacaa   1500
 agacctaaaa agcctttttt aagaaataaa ttttttgttc acatgaccaa agcccctcct   1560
 gtgtgtgtta ataaaagaat cataaac                                       1587



      <210> 475
      <211> 2469
      <212> DNA
      <213> Homo sapiens


      <400> 475
 tttttttttt ttgagacagt ctcactctgt tgcccaggct ggagtaaagg gcagtggcat     60
 gatctcggct cactgcaacc tccgcctcct gggctcaagc catcttcctt agcctcccaa    120
 gtagctagaa ctacaggtgt gtaccaacac gtatggctaa tttgttttgt tttttttgtg    180
 tgtgtggaga cagggttttg ccatgtttgc ccaggttggg ctcgaaagcc ttaggctcca    240
 gtgaatttgc cccacctcag tctccctaag tgctggggat tacagacgtg aaccactggg    300
 ccccagccca aaccttcacc ttctaagggc actgggatga acagaccgat cggcttgagg    360
 gtgggcaaag gggtgtgggc taggttataa ggaagtggta ccaaataact gtgtgcctga    420
 gttccaccgc aagattacta aaagcaggac cagaccagaa actgctaaag aacatggcct    480
 gtttgacatg ttcatgagtc acctgaccca cagcatatat gcttatgact aaaccctcca    540
 ctcctgattc tcaagagtgt atcacctgtc agcaaaatga atagtgggat attttgggcc    600
 attttaaatg tgaaattttg cctctttaat gttaattcaa aactatatca atgttttctt    660
 gttcccacct ctaacccaag gaaaaaagag aaaacatact atgcaaagga agtttaaact    720
 taagttttcc ttaagggtca gcccaacaat gactttcagt caaatggatt aaactggaaa    780
 atgtttttgt ttctgttgta aacagatcat cctaggcgga aagttttttt ttgtttgttt    840
 tgcttttaaa ttagtttatt tcctaaatcc tagtcttcca catttcctag agggccacct    900
 gacacaagtc cctgtatctg aagtctagca tctcaaggct gatctggaag tgtgctagta    960
 tgctccctag tggataactt aatcttttaa tacagttccg tcattcccat cttgttttca   1020
 gaagagaagg tggctacagc caggcataac atatccactg tgtgcataga gggtctcttc   1080
 acgttgatgc ttggcattcc atcagctttc tctaagtctt tgctcaagtt caaccttaaa   1140
 atgatgttag acaacaggtc ccagtcagtt ccctctattt tcacccattt tgctcacaag   1200
 ccatattggc ccgattagtg gtactgtctg actcacgtgt gtgatccaaa taaaggtagc   1260
 tgctgaccac tgcctggttt gttttgtgga ctaggggata gagaatccag ggttctctca   1320
 tgaggagtta aacatatttc aagagcaaca ggaaaaaagg tacatcaagc catttggaaa   1380
 ccaaaaattt attgctttct ccttccaaaa gcttttgtga attttacaaa aaaaaaggat   1440
 gaaagttcac caaactgctt agtcccagct aaagcataag agggtgagaa cggtacactg   1500
 cagggccacc cagcagcagc tgtgcactga tgttaaaact ggctccccca gacttgtagt   1560
 gctgtcttca gggggctgca ttccttacac gccacctctt gtgacatagg tcattggtca   1620
 agccgctgga atgctacaga ggtttttttg gttttgagag gctttttttt gttttgcctt   1680
 cctactataa aagcgaaatt ttcagttcat ttctgaaaaa taaattggtc aataaattca   1740
 ttttgttctg cttctacttt acacaaagct tcatattcaa cccgatacct ttctagctgc   1800
 attttctttt ctgctattag ggcttgaagt tgctgctgtt gagcttctct ctgctttgct   1860
 atagatttga gcaagttccg agcaccgatg gccttcatct tttcattttc tgcttctttt   1920
 gcaagttgat caacaagctc aattaaacca ccaactattt tctgaaactg gccaattttg   1980
 tccacaaagt ctttgcactc ttccttcagc tctatggtct gctgggtaac ctctgggtcc   2040
 aacaccctca gcttgttcag ttcatcaaag tgtagccctg cttcacccag gatgtccttg   2100
 gccatggctg tttcccatcc aggttcccta gaggagttct gctctgaagg agtgacagtg   2160
 gcagtcagga ggaggtgtgt cataggagca agggtcagga aagaataaag tccgcttgct   2220
 tgtcacaggc atcgttcatt caacacacat ttcttgagtg cctactacat gccaacactg   2280
 ctagatgctg ggggtacaaa gatgaatgca acacggtgcc cgccctgaag agcacatagt   2340
 tcagctgccg gccccgcggc ggcagcgcgc tgcagcccag gctgatgtag acaggcagct   2400
 tctcctgggt cagcgacagc cggtacccag ccagcctgcc acggccgctg ccacggatac   2460
 agagcctgt                                                           2469



      <210> 476
      <211> 1429
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1429)
      <223> n = a,t,c or g


      <400> 476
 aagaggcgtg gcggcgctgt gcgcgtgcac aaaagagagc tgaggggcgg gggcgctgcg     60
 gcacagctgg tttgagcaac tgaactggaa acaagatgca ggaccccaac gcagacactg    120
 aatggaatga catcttacgc aaaaagggta tcttaccccc caaggaaagt ctgaaagaat    180
 tggaagagga ggcagaagag gagcagcgca tcctccagca gtcagtggtg aaaacatatg    240
 aagatatgac tttggaagag ctggaggatc atgaagacga gtttaatgag gaggatgaac    300
 gtgctattga aatgtacaga cggcggagac tggctgagtg gaaagcaact aaactgaaga    360
 ataaatttgg agaagttttg gagatctcag ggaaggatta tgttcaagaa gttaccaaag    420
 ctggcgaggg cttgtgggtc atcttgcacc tttacaaaca aggaattccc ctctgtgccc    480
 tgataaatca gcacctcagt ggacttgcca ggaagtttcc tgatgtcaaa tttatcaaag    540
 ccatttcaac aacctgcata cccaattatc ctgataggaa tctgcccacg atatttgttt    600
 acctggaagg agatatcaag gctcagttta ttggtcctct ggtgtttggc ggcatgaacc    660
 tgacaagaga tgagttggaa tggaaactgt ctgaatctgg agcaattatg acagacctgg    720
 aggaaaaccc taagaagccg attgaagacg tgttgctgtc ctcagtgcgg cgctctgtcc    780
 tcatgaagag ggacagcgat tccgagggtg actgaggcta cagcttctat cacatgccga    840
 actttcttgt gacaaattgt ctggattttt taaaaaagga aaaagcaaga atgaatcctt    900
 gtggttttta gttttgtata aattatgttt caaatcttta cattttggaa ataatcattg    960
 ctggagattc tgttaaatat tttggaactc ttttttaaat tatagtattt cctctaaaaa   1020
 aaattaaaac cagctattgg tatggcacat gggtattttc ctcatttata ttttaagtaa   1080
 gccataaaac ctagtcacta ttttttgaca tataactata aaaagaaata cagttttaaa   1140
 tgtgaataaa ttatacagtg gaaaattgca gactaagcct tatagataca ttgtttattt   1200
 ttattttata aagagagcag tgagattatt aaactacagg aatggtctct aggacaaaag   1260
 aatgttagta ttgaagaaac agacaatttt tgtgaaacat tcccttattg aagcaataac   1320
 tgaaagtttc cagtttactg ccatatttgg ttaaatgtgt tttcttgtta aaatagttta   1380
 tctcagactg ttaactaann nnnnnnnnnn nngagaggga gcttttttg               1429



      <210> 477
      <211> 414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(414)
      <223> n = a,t,c or g


      <400> 477
 gtgcagcaac caacaagaaa acactggcag attacgcccg tgccttatcc ggagaggatg     60
 aatgacgcga caggaagaac ttgccgctgc ccgtgcggca ctgcatgacc tgatgacagg    120
 taaacgggtg gcaacagtac agaaagacgg acgaagggtg gagtttacgg ccacttccgt    180
 gtctgacctg aaaaaatata ttgcagagct ggaagtgcag accggcatga cacagcgacg    240
 cangggacct gcaggatttt atgtatgaaa acgcccacca ttcccaccct tctggggccg    300
 gacggcatga catcgctgcg cgaatatgcc ggttatcacg gcggtggcag cggatttgga    360
 gggcagttgc ggtcgtggaa cccaccgagt gaaagtgtgg atgcagccct gttg          414



      <210> 478
      <211> 936
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(936)
      <223> n = a,t,c or g


      <400> 478
 taccatcgtg gctcgctgca acctccgcct cccaggagaa ttgcttgaac cctggaggcg     60
 gaggttgccg tgagctaaca ttgcgcccct acactccagc ctgccaacag agcaagactc    120
 cgtctcaaaa ataaaaaaag gatctacttt tgagaatact gtcattggtt gataaaatac    180
 agcagaaact tgtgaagaag ctattttcca tattcacctg gcatgtttgg agatgattgc    240
 catcaacttt gtgactgtga aggagaaacc ttctgccacc caaaaactga aaaatgcctc    300
 tgcccccgtg ggagaactgg agccagatgt gatgctggtt agtctcctgt attgggcgtt    360
 cagcatggat gttgcctttt tctgacctca agacaactat ccaactttcc ctgtgtcctt    420
 cacgatgcaa ccactaaagc tctactgaag tctctaattc tgaagaggca ccttaagaat    480
 tggaatctaa tgacttgctt ggaatcatat gctcctaagt ggggcagaac tcaggttgcc    540
 caatcaagaa gcacagtcct gacgacagca tgctgcattg ttaacgctcc cacgaggtgg    600
 aaatcatagc cggaaatttt gaaggtataa aattttgtgg agccgaaaaa gaagagaaga    660
 gctgttttta gagcgaagct tttcccttgg ggggtgtttg tgtgccagcc gcgttaaagc    720
 ggtatggaca attggtccca atagcgtggt gaccctgccg ctgtgaatcg agcacccgtt    780
 ctctcatgcc ggtatggatg cgcgcgtgac ctgatcgggt ggtggaggat agcgccggga    840
 tattcttctc gtcgaccgaa taaggtgtgt tttctcaaaa aggtgggtgg ctctggtgtg    900
 tgaccattng tggtgacaaa cgacgaccta acggtg                              936



      <210> 479
      <211> 1449
      <212> DNA
      <213> Homo sapiens


      <400> 479
 tttttttttt ttgatagtgc tttgtcttta tttctgatgc ccatcttctt cagaggttaa     60
 gaagaaatga cactgatgta caaatgactc accaagggac tctcacctga ctctaccctt    120
 gcaggggtgg aataaatccc ttctattttc aagtctattt gtcccatttc tgtttagaca    180
 taatttgaaa gccagcttgg accttgtact tttcaattat gttaacgtaa aatactcgta    240
 acgaatgtag tatgagttta aagtgagctt ttcagatcct ataagtgcat cctaagtaat    300
 gacaggcttt aagataagga atatatgcct tttgttaagg cagaaatttc ataaaatttc    360
 atgaaaaacc atggtcaatc caatgatgcc ctttttaaga caagtttgtt tggaaactgg    420
 aagggtcaaa agacaacaaa aaagcccccc cccaaaaacc tccctttaag caaatttata    480
 acttgaaaaa aaaaaaagcc taagaatatt ctgagagtgg tacatagttt tatagtagcc    540
 acagtaactt ccagtgactg gcaaatttct ttgcatcagc tggcatgtgt ggtgaatgga    600
 attcccatga acagctctta catccttccg ctttccttct acaggcctcg gtcttgtttc    660
 caaaggtgac tgcagtgagg atgtaaggtc catgacctct agggataatg ccatccactc    720
 aggaagaaag atgctgagaa actctaggga tatctaagtt tacatcacag ggggagaatc    780
 aattgtggag gttttaagaa gacatttgaa tttttgcccc taatcaagaa gtgttttgcc    840
 atctggttta cattcaataa ctagttggct catcatttgc agaaataaac tttcctctag    900
 attaggaaac ttcatcatga gatctgagat atactggttt ggaaagtttc ctcagtttct    960
 cttggcttcg aagtccccgg cctcggagtg gggtaaggcc cattggaggc agatgaattg   1020
 gccttgggta aggaatcttg taatgcagtc caatttcaat cctggctgtg cattcatcta   1080
 tacactgttt aattaggtct gtgtccgtga gatttttgtt tttccggaac agcgttctgg   1140
 cttcatttag tatgtactgt ttttctttga tggtgtcttc catctgccct gatgtcgcct   1200
 gccatttcct cgcaagcctg aaaatgctgc ggtagaggcc aaggacttct tgtcgtgttg   1260
 ccgttgtcat tctgagtcag tcctgccttc ccccacccac agaagcgcgc agcccgcggc   1320
 gggctgggag gaggcggcgc caggagccca gcagagccgt ggccgaccga gcacaggctg   1380
 gtccagtagg ccaggccgga ccaaaccacc gggcccacct ctgtggagca ccagttccct   1440
 cgtgccgaa                                                           1449



      <210> 480
      <211> 1456
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1456)
      <223> n = a,t,c or g


      <400> 480
 tttttttttt ttatgagatg gaaggtttta ttagactagg agatttgtgg gaggtatgag     60
 cgctgggcca aggtggcacg ggccatgctc aaggcaccct ctcgggtgcg gtgaccgcca    120
 atgaagccgc ttgcatggac gaagatgcag ccagggatcc cactgacctg gtccagggcc    180
 tcgtcccgaa gaccccgcca tggctctggc aggggcagcc ggctttggaa tgagtggggc    240
 tccttgggca cacactgtat tcgccactgt ccagcctggt cagtgtagat aacaaagaag    300
 atggccactg gaggggacag cccagattcc aggtggtaga gatgctcctt ccagggacat    360
 gcacctttcg ccagttccac aatctctcca cttgggtcca cctggaatcg ctgggcaagg    420
 gcctcttcca ccaaggcccg ggctggcagc cagctgtgtt ggtagaaatc taatctctgc    480
 agaaactcct cttgaaccag atccattgca cgcttgaacc ctgcctcagt gtcttggtcg    540
 gggtggttcc aggtaggatt aagtcgagca actcgtgcac tcagggtagt ggtcagtgca    600
 tatcgaggct ccccctctgc ccactgggag atcccattgt ccacagcatc cacctcctcc    660
 acaaagttct catacatctt gtcatagagg gtgcccacca tgctgtcctc ttcactagtg    720
 cccagcaact gggccagcag cttgtgcccg aagtgcagat agatgagtcc cgcactgctc    780
 agcttggtct gccacggctt cccaggggac agggagctca tggtctctgt gaaagacctc    840
 tggtgatggt catatcggtg tctccgaggg tcgtactcgc cccccacgtc caccacgatg    900
 tcacaggaag cgagtttttc gggatcccgg gtccgcacaa tctctgcatc ccggtactcc    960
 ggcaggaggc gaagcagtgc gcatgccagt gcctcgtcgc agtggaaggt gccattgtgc   1020
 gtcccgattc ggggcggtgc catgagtttg ctgcgggatc gttttggggg cgggacggac   1080
 tctggaccga gcatgcggtg ccgggtatac aggggtggcg gcggcagcag cagcgttaag   1140
 aggccgcgca ggaagcggtg tcccataagc agctccctgc agggaggcag gagcgccgac   1200
 ccggaagagg aagcgccagc gcagccccac ttccgcttgc caaccgttcc cttggcaacc   1260
 agctctgcag agtgagcagc agcagactcc cagcctagga tttcttccag ctggtcaaag   1320
 ggccctgcga tggagcctcc aagaggcgca tcgcatcacc cctgcgcatc angctctgag   1380
 acggngcccg cactctcgac cacaccccca tctcatcacg agtcccttgc ttaatccaag   1440
 aaaagaccaa cattct                                                   1456



      <210> 481
      <211> 1652
      <212> DNA
      <213> Homo sapiens


      <400> 481
 accagaatgc aaaggtgggc agcgaagcca tccaggtgct ccccgccttc ccccgcgagg     60
 tccaacgcct gcccgagcct gccaagtcct gccgccagcg gcagctggaa gccagaaagg    120
 cagcagccga gaagaagaag attcagaagg agaagctgag cactccggag aagatcaagc    180
 aggaggccct ggagctggcg ggcattacgt cggacccagg cctgtctttg aagggtggat    240
 tgtcccagca aggcctgaag ccctccctca aggtggagcc gcagaaccac ttcagctcct    300
 tcaagtacag cggcaacgcg gtggtggaga gctactcggt gctgggcaac tgccggccct    360
 ccgaccctta cagcatgaac agcgtgtact cctaccactc ctactatgca cagcccagcc    420
 tgacctccgt caatggcttc cactccaagt acgctctccc gtcttttagc tactatggct    480
 ttccatccag caaccccgtc ttcccctctc agttcctggg tcctggtgcc tgggggcaca    540
 gtggcagcag tggcagtttt gagaagaagc cagacctcca cgctctgcac aacagcctga    600
 gcccggccta cggtggtgct gagtttgccg agctgcccag ccaggctgtt cccacagacg    660
 cccaccaccc cactcctcac caccagcagc ctgcgtaccc aggccccaag gagtatctgc    720
 ttcccaaggc ccccctactc cactcagtgt ccagggaccc ctcccccttt gcccagagct    780
 ccaactgcta caacagatcc atcaagcaag agccagtaga cccgctgacc caggctgagc    840
 ctgtgcccag agacgctggc aagatgggca agacacctct gtccgaggtg tctcagaatg    900
 gaggacccag tcacctttgg ggacagtact caggaggccc aagcatgtcc cccaagagga    960
 ctaacggtgt gggtggcagc tggggtgtgt tctcgtctgg ggagagtcct gccatcgtcc   1020
 ctgacaagct cagttccttt ggggccagct gcctggcccc ttcccacttc acagatggcc   1080
 agtgggggct gttccccggt gaggggcagc aggcagcttc ccactctgga ggacggctgc   1140
 gaggcaaacc gtggagcccc tgcaagtttg ggaacagcac ctcggccttg gctgggccca   1200
 gcctgactga gaagccgtgg gcgctggggg caggggattt caactcggcc ctgaaaggta   1260
 gtcctgggtt ccaagacaag ctgtggaacc ccatgaaagg agaggagggc aggattccag   1320
 ccgcaggggc cagccagctg gtcttctacc agcacaagaa cctcaaccag cccaaccacg   1380
 ggctggccct ctgggaagcc aagatgaagc agctggcgga gagggcacgg gcacggcagg   1440
 aggaggctgc ccggctgggc ctgggccagc aggaggccaa gctctacggg aagaagcgca   1500
 agtggggggg cactgtggtt gctgagcccc agcagaaaga gaagaagggg gtcgtcccca   1560
 cccggcaggc actggctgtg cccacagact cggcggtcac cgtgtcctcc tatgcctaca   1620
 cgaaggtcac tggcccctac agccgctgga tc                                 1652



      <210> 482
      <211> 652
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(652)
      <223> n = a,t,c or g


      <400> 482
 gaacctggga ggcggaggtt ccagagagcc aagatcgcac cactgcactc cagcctgggc     60
 gacagaacgg agaccctgtc tccaaaggaa aaacaaaaaa gaagaataaa ataatttgga    120
 tgcaaatcat gtttatttaa atagtaatgt catgagacta ttaaagatgt gccagagttt    180
 caatgaaaat cattaaagta ggacagctaa gaaattaata ttaatatcaa aattattgat    240
 aatcttaaat tattgattat tccttaacgc actccattct ccttttacat tttatcatgt    300
 ttcttttgaa tatatgaatt ggcaaaggac ttgatgaaac tgagtactaa gatttggtac    360
 agagtatgtc aggaagacaa ctcagattgc cattttaaat aaagttgtac atgaacaata    420
 attggaatca tcaggtaatt tttttaaaca aaggttcttc atttactgtt atgattggaa    480
 aaaaattaga aaataaagta agtgccatag gctaattaaa aaataaaacc ttggccgggc    540
 gcggtggctt acgcctataa tcccagcact ttgggaggcc gagacgggca gatcacgngg    600
 tcaggagatt gagaccatcc tggctaacac ggtgaaaccc catctgtact tg            652



      <210> 483
      <211> 416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(416)
      <223> n = a,t,c or g


      <400> 483
 caccccttgc tcagcctata taccgccatc ttcagcaaac cctgatgaag gctacaaaaa     60
 aaaaccagaa aaaaaaaaaa aaagaaaaaa tataaaaaaa aaaaaggggg ggggccttta    120
 aaaaattccc ggggggggcc aaagttaccg gcgccgttgc gaagactatt tttttccttt    180
 ttggggggac ctttaaaaac gcttcgggaa tttttgaaaa aaaccttttt tttggggggg    240
 gaaaaaattg gaaaaacccc cccccaaaaa ttaaacccct tggggaaaaa aaaaaatttt    300
 aagggggaaa ggggggaaaa acccccgaat gggggggggg gtaaaaagtt ttggggnnnn    360
 nnnnnnaaaa caactttctt tttggggggg gggatttgga acaacccctc ccaaaa        416



      <210> 484
      <211> 430
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(430)
      <223> n = a,t,c or g


      <400> 484
 aacctttcag caggaccaaa ttgatcaaga ttaccagaaa gtgggctccc ttcgtgacag     60
 ggcaggactg catcacccac caccagcagg ctgtgcaggg caaggtcctc gcaggggctc    120
 aagttgggta tataggcagc ttcagtataa tatgccttag caatccactt aaaaaaaaaa    180
 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaannnggg gggggggccc tttaaaaaaa    240
 aaaatttttt ccgccggggg gggggggagt tttttttttt tttaggggcc ccaaaaaaaa    300
 aattcggggg gggggtataa aaaagggggg gggggaaaaa acccggggaa aacaaaaaaa    360
 aaagggtggg aaaaaaatcc ctttttgggg ggggggaaaa aaaaaaaaaa acgnnnnnnn    420
 nnnnnngnga                                                           430



      <210> 485
      <211> 401
      <212> DNA
      <213> Homo sapiens


      <400> 485
 cccacgcgtc cgcggacgcg tggggtgtat tttatgtgtg gcccagggaa gccaaatgat     60
 tggacatccc tgccttagac tgaaatgtct gtggtgataa aatttcactg cattaggatg    120
 acgacatagt aaaaattcaa gcattaatta ttacctgaag cttctctatt tccgtctttg    180
 cagcttgcct ggctttgccg atggcacagc cccaataacc ctatttagaa aaaaatatat    240
 ataatcactg aattagtaca ctatcatatg taattaatga ctactaatgt ttctataacc    300
 tagtgaaagg atgctaaatg acttttaaaa gcaagtatag aaaaatatag tcaaacacat    360
 tctgatgaat gccaaagggc tcaaaaatac taaaatacca c                        401



      <210> 486
      <211> 389
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(389)
      <223> n = a,t,c or g


      <400> 486
 acgagggcgt gactggcggt aacgcancgt atcctatgtt tcaggtgcag ccggtgcagc     60
 acgtgtatcc tgcccaggtg cagtacgtgg aagggggaga cgccgtctac accaatggag    120
 ccatgtgcgt gcttctcccg cgggccacac ccggaaccct ctccctgact ccagcctttg    180
 ccacctgggg aggcatcaag caaattcctc tcccttatgc ttttggcgat gtgttcacta    240
 aatactgtta aaatgctatt aggaaactgg gcaatatctc tacagaaggt tttaaaatta    300
 gccggacatg gtgacaagtg cctagagtcc ctcccaggta atcggggggc cggggtggga    360
 ggatcgcatg ggcccaggag ttggaggct                                      389



      <210> 487
      <211> 707
      <212> DNA
      <213> Homo sapiens


      <400> 487
 catagaccgg acggttgtcc agacatcggc cccacgggag agctgagtgg tagcttaaag     60
 attcccaacc gggacagcgg gatcgacagt ccctcctcca gtgtggctgg agagaacttt    120
 ccctgcgagg agggcttgga ggctggccca agccccactg tactgggggc gcacgcagag    180
 atggccctgg acagccaggt cccgaaggtc accccccagg aggaggcgga cagcgacgtg    240
 ggtgaggaac ctgactctga aaacaccccc caaaaggctg acaaggatgc cggcctggcc    300
 cagcactctg gcccccagaa gcttctccac attgcccagg agctcctgca caccgaggag    360
 acctatgtga agcggctgca cctgctggac caggttttct gcaccaggct gacggatgcg    420
 gggatccctc cagaagtcat catgggcata ttctctaaca tatcctccat ccaccgcttc    480
 cacgggcagt tcctgctgcc ggagctgaag acgcggatca cggaggagtg ggacacaaac    540
 ccacggctcg gggacatcct gcagaagctg gccccattcc tgaagatgta cggcgagtat    600
 gtcaagaact ttgaccgagc cgtagggctg gtgagcacgt ggacccagcg ctccccactg    660
 tttaaagacg tcgtccacag catccaggta aggcgtcgac gcggccg                  707



      <210> 488
      <211> 377
      <212> DNA
      <213> Homo sapiens


      <400> 488
 ttcgccattc tgcttgttgg ccgtcatggt ctggtgagag gggtcggcgg tgctggggag     60
 actgctcacc attttggggt ttgccgcttt gccttcagag ggcttattgt gagtggatga    120
 ttttcgggaa aagttactct gtttcccaga ggttgctgcg tgcgcattca gcagaggcag    180
 cagggagctg cagggagttc ttgaggaata gttgttcttt ggatgtggaa tttctccgca    240
 gagcatgatt tgggccttca gctgttcgat gtcacaggaa aaccgggcag ctttcccgag    300
 ctcctcgtca tatttacgct cgctgacaaa gtgcttaatt tctgccctga gttcggccag    360
 ctgcatctct gccatct                                                   377



      <210> 489
      <211> 377
      <212> DNA
      <213> Homo sapiens


      <400> 489
 ttcgccattc tgcttgttgg ccgtcatggt ctggtgagag gggtcggcgg tgctggggag     60
 actgctcacc attttggggt ttgccgcttt gccttcagag ggcttattgt gagtggatga    120
 ttttcgggaa aagttactct gtttcccaga ggttgctgcg tgcgcattca gcagaggcag    180
 cagggagctg cagggagttc ttgaggaata gttgttcttt ggatgtggaa tttctccgca    240
 gagcatgatt tgggccttca gctgttcgat gtcacaggaa aaccgggcag ctttcccgag    300
 ctcctcgtca tatttacgct cgctgacaaa gtgcttaatt tctgccctga gttcggccag    360
 ctgcatctct gccatct                                                   377



      <210> 490
      <211> 1292
      <212> DNA
      <213> Homo sapiens


      <400> 490
 gcacgctgca gacccttgcc ccggctacgg tgcagacagt tgctgcgcca caggtgcagc     60
 aggtcccggt aagtggctgg aaaggattca gggaggcact ggttggggct gttaactggt    120
 ccttggttga agatgtggtc tttatggctg cggtccagaa cccggccctc accgccctca    180
 ccacccctat ccagacggct gcccttcaag taccagtaag agctgccttc tcccccaccc    240
 tcctccctcc ccctttattc ctggaggtgt tagtcttcag agatgttaag caggtacctg    300
 ggggagtcaa gcagcttgag ccccccaaag aaggagaaag gcggacaacc ccataatatc    360
 attgagaaac gaatacgctc ctcccatcaa tgacaaaatc atcgaattga aagacctggt    420
 catggggaca gacgccaagg tgggtgccaa gcaaaattgt gttttatgtt ccaccatctc    480
 ccctctacct gtttttgcct caggagccta gagaagtccc aggctcaagg taagtgaata    540
 caagaccgag ttagaggtgc ttttttatta aagcatcttg gtgtcatgtc aagattataa    600
 aatattaaaa aacataaggg actggtgagg gttgataagg cagtgacccg ctgagacctt    660
 tgactccttt ggctatgctc tgcagttgat ggggactcca ctgtcagagg cagagaaaga    720
 tgcctgccac tcagtagttc cagatacagg actgtgtgta ccttggagtc agctgatggc    780
 atagttttag ctgtgtttag gggttacctt ttaaggaaaa gaaagaaaaa agaggttgag    840
 tctttgacca gcaacacata gaggaaactg atgttccaaa tgtttctggt gtttcagtgt    900
 atgtgtcttc tagaaagtag gagattttat ttttaaaacc tatctatgtt taaaccctat    960
 tttgaaagaa aatttcattt tccttgccta caaatctgaa agctgtacat cctaagtaaa   1020
 aatctatgcc caaagtgctg ggattacagg cgtgagccac cgcgcccggc cgaaagccaa   1080
 ctcttatgcc tagaaatatg tgcacctatg accaagccca tgaattatac aggaattatg   1140
 taattatgag tgatgtactt caaagttatt gcacatacac ttgtttactt tgtatgtttg   1200
 caggattaaa ctttgtataa tctttttaca aaaatttttt ttcagtatgc aagcttgcaa   1260
 gatgaaaata aaacctgttt gcctgatagt tg                                 1292



      <210> 491
      <211> 344
      <212> DNA
      <213> Homo sapiens


      <400> 491
 atccactgct gtgcgggcac acatactcac acaggtaagc ggggaaacgt acctatgcct     60
 ctggcaaaat attctcggca taaatgaagg tcattttcac aggatattaa aattatttcc    120
 gacaaactct aaggaaaaga aaatgagttt ctcagtgacc gaacgctgaa tgtgatacag    180
 ggcaatgacg gactcgctgg cggactccac tctacccacc gagttctgct tgtgctccat    240
 gagcttccgg aaagatggct gcttggataa cacctttcct cctgcacact ctacgattgc    300
 cttcatagtg gaaagacttg ggcagattcc aggtgtgatg taaa                     344



      <210> 492
      <211> 557
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(557)
      <223> n = a,t,c or g


      <400> 492
 gggggccngn naattgagnn aactgacgan ctgctgcaaa cggcacgagc caaataggaa     60
 cagctctagt ctacagctcc cagcgtgagc gccgcagaag acgggtgatt tctgcatttc    120
 catctgaggt accgggttca tctcactagg gagtgccaga cactgggcgc aggtcagtgg    180
 gtgcgcgcac cgtgcgcgag ccgaagcagg gcgaggcatt gcctcgcttg ggaagcacaa    240
 ggggtcaggg agttcccttt ctgagtcaaa gaaaggggtg acggacgcac ctggaaaatc    300
 gggtcactcc cacccgaata ttgcgctttt cggaccggct taaaaaacgg cgcaccacga    360
 gattatatcc cgcacatggc tcggagggtc ctacgcccac ggagtctctc tgattgctag    420
 cacagcagtc tgagatcaaa ctgcaaggtg gcagcgaggc tgggggaggg gcgccctcca    480
 ttgcccaggc ttgcttagtt aaacaaagca gccaggaagc tcgaactggg tggagcccac    540
 cacagctcaa ggaggcc                                                   557



      <210> 493
      <211> 409
      <212> DNA
      <213> Homo sapiens


      <400> 493
 gaggccgagt ccgacttttg ataactggga cgtgtgcgca aacatgtttg gcaccttctt     60
 tgacaccgag gaccctggcg agttcaagat gaagtactgg ggcgtaacct cctttctcca    120
 gaaaggaaat gatgaccact ggatcgtcga cacagactac gacacgtatg ccgggcagta    180
 ctcctgccgc ctcctgaacc tcgatggcac ctgtgctgac agctactcct tcgtgttttc    240
 ccgggacccc aacggcctgc ccccagaagc gcaaaaaatt gtaaggcagc ggcaggagga    300
 gctgtgcctg gccaggcagt acaggctgat cgtccacaac ggttactgcg atggcagatc    360
 aaaaagaaac cttttgtagc aatatcaaga atctagtttc atctgagag                409



      <210> 494
      <211> 355
      <212> DNA
      <213> Homo sapiens


      <400> 494
 ggcacgaggg cagggtggta cagtcgagag tgagccagac tccggtgtgg ggctgtgatt     60
 gctgagcgac ttctggcaag tcactgcccc ctcctgtggg gagatgcatg gatgagcttg    120
 gtatgttctc caaagcccca ggtattctgg ggccacacag gcagtgatga caggggtaca    180
 ggcccaggtt tcctcctcct gctggagcag ctcctgtggt ctcaagcacg taggagattc    240
 tgactgctta aaaaacaagt gtgggccggg cgcggtggct cacgcctgta gtcccagcac    300
 ttttggaggc cgaggcgggc agatcatctg aggtcaggag ttcgagacca gcctg         355



      <210> 495
      <211> 249
      <212> DNA
      <213> Homo sapiens


      <400> 495
 gggcaatgtt ctgcctgttc tgtacgggga aatgcgcgtg gggtcacgcg tggtttctca     60
 ggagatcagc acggcagacg aaggggacgg tggtcaggtt gtggtgattg gtcgctgatg    120
 caaaatgttt tatgtgaaac cgcctgcggg cggttttgtc atttatggag cgtgaggaat    180
 gggtaaagga agcagtaagg ggcatacccc gcgcgaagcg aaggacaacc tgaagtccac    240
 gcagttgct                                                            249



      <210> 496
      <211> 433
      <212> DNA
      <213> Homo sapiens


      <400> 496
 ggacggaaca gaagtccaaa agcaaacagc accgagtgtc aaggagagca cagcagagag     60
 cagaatctcc tgaatctagt gcaattgaat ccacacagtc cacaccacag aaaggacgag    120
 gaagaccatc aaaaacgcca tcaccatcac aaccaaaaaa aaatgtccgt gtaggacgct    180
 ccaaacaagc agctactaag gaaaatgatt caagtgaaga agtaaatgtg tttcagggta    240
 gctctcctgt cgatgatatt ccacaggaag aaacagagga ggaggaagtt tctacagtaa    300
 atgtacggcg gcgaagtgct aaaagggaac ggcgatgaac aaatgtaatt aataactttc    360
 tctgtgaaag ctttggaaaa atcttttttt tttttttttt ttgggccaac tttggggtgg    420
 aaaaaacctt ttt                                                       433



      <210> 497
      <211> 179
      <212> DNA
      <213> Homo sapiens


      <400> 497
 caattaccgg cgtcgcccgc gtcctcctaa cgctccttca caagatggca aagaggccaa     60
 ggcaggtgaa gcaccaactg agaaccctgc tccacccacc cagcagagca gtgctgagta    120
 acaccaggct cctcaggcac cttcaccatc ggcaggtgac ctaaaggtcg acgcggccg     179



      <210> 498
      <211> 179
      <212> DNA
      <213> Homo sapiens


      <400> 498
 caattaccgg cgtcgcccgc gtcctcctaa cgctccttca caagatggca aagaggccaa     60
 ggcaggtgaa gcaccaactg agaaccctgc tccacccacc cagcagagca gtgctgagta    120
 acaccaggct cctcaggcac cttcaccatc ggcaggtgac ctaaaggtcg acgcggccg     179



      <210> 499
      <211> 405
      <212> DNA
      <213> Homo sapiens


      <400> 499
 ggaagacaga gaatgaccac atcaacctga aagtggccgg gcaggacggg tccctggtgc     60
 agttcaagat caagaggcgc acgccgctga gcaagctgat gaaggcctac tgcgagaggc    120
 agggcttgtc aatgaggcat atcacattga ggttcgacgg gcagtcaatc aatgaaactg    180
 acactccagc acagctggag atggaggacg aggacaccat cgacgtgttc cagcagcaga    240
 cggagagtgt gccggatagc atcctggcag ggcacagttt ctagagggcc cgtccccagc    300
 ccgggccgtg catcctagca ttgctgttga atggtgagca cgtgaccatg ccgaccacaa    360
 aggtgtctgc ggaaactcga ggacattcac cacgatgatt gtgct                    405



      <210> 500
      <211> 483
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(483)
      <223> n = a,t,c or g


      <400> 500
 cgagagagtc ctggagaatg tggaacatta tcaggaattg aagaaaatgg tccaacagtc     60
 cgaccttggc cagtatgtga ccttcttgag gtctttctca gacaaacaga aaatctccct    120
 cctccacagc tgcacgtgtg tgctttacac accaagcaat gagcactttg gcattgtccc    180
 tctggaagcc atgtacatgc agtgcccagt cattgctgtt aattcgggtg gacccttgga    240
 gtccattgac cacagtgtca cagggtttct gtgtgagcct gacccggtgc acttctcaga    300
 agcaatagaa aagttcatcc gtgaaccttc cttaaaagcc accatgggcc tggctggaag    360
 agccagagtg aaggaaaaat tttcccctga agcatttaca gaacagctct accgatatgt    420
 taccaaactg gctggataat cagaatgttt ntaagatctc cattaatgtc attnttatgg    480
 aan                                                                  483



      <210> 501
      <211> 976
      <212> DNA
      <213> Homo sapiens


      <400> 501
 aaagctgact tcatgagacc gaggatctcg ttcgttgatc gatgctacat attcagcatg     60
 ttagataatg aggttggagc gaatccacgc ggaggtcacc agtgtggaag tgctttaagc    120
 tgtgacgagg gagttcctgc agctcaggga gccagtagtg agaaacccca cgaatgcacg    180
 aagtgtggga aagccttgtg ctgcagatcg gacctcaggg tacatcacgg ggtccacgcg    240
 ggggagaagt cctctgcgtg cagtgaacgg gggagtggtt tcagggagaa gctttgccct    300
 gacaaacagg gaactcacac aaaggagaaa cccgctagag acagcagaag tggtaaaacg    360
 atcttccgga agacacgcct gtgtgtcccg ggcacagttc acgccggagc gaagccttac    420
 aagtgttggg agtgtgagaa aacctcccac aagtcgcgcc tcatcgagca ccttcgctcc    480
 cacacggggg agaagccctg cggctgcagg gaatgcggaa aggccttttt ccagaagtca    540
 cacctcatcc tgcgtcagag gactcacacg ggggagaagc cctgcggctg cgcggagtgc    600
 gggaaagctg ctcccaggac tcctgcctcc tgacccacag gcggactcgc ggggaagaaa    660
 ccgtacgagt gctcggactg cgggaagacc tcccggaagg cgaacctcat ccgccaccac    720
 gggatccaca cgagggagaa gctgcatggg tgaagagacc gtgggatcgt cacaaagtca    780
 catcacgagg tcgccgaacc tctaggaggg acatcgccag ggaaacagcc ctcaaccaaa    840
 actacgacgc caccctaggc agaggtccca tatcggggtg aaattcggcc actttggtgg    900
 cttaaggaag gcatggtcag ctgggcgctg tggctcacgc ctgtaatccc agcgctttgg    960
 gacgccgagg cgagtg                                                    976



      <210> 502
      <211> 360
      <212> DNA
      <213> Homo sapiens


      <400> 502
 tcgtttggcc tttgccctgc agggatgcgg acgcacagag cgaaggtatt aacgcctctg     60
 cccggtaccc gaaaaactgg gtgaccaccg gcgatccggc gcgtgagttc accatgattc    120
 actcagcacc gctgatgctg ctggctgacc ctgatgagtt cgagtccgta caactggcgc    180
 aatcatggcc cttgggggcc attgtttctc tgtggaggag tccatgtcga aagatgaact    240
 gattgcccgc ctccgctcgc tgggtgaaca actgaaccgt gatgtcagcc tgacggggac    300
 gaaagaagaa ctggcgctcc gtgtggcaga gctgtaagat gagcctgatg acacgaggcc    360



      <210> 503
      <211> 502
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(502)
      <223> n = a,t,c or g


      <400> 503
 agagttgcca gactacnccc caactgaagg cgttcngata gcagtaggaa naacccaaca     60
 nccccgacga agatacccca cgcagaccct ttaaagagac ctatcgagga tttgaattca    120
 accttcgccc taaacactga tggtcttctc taaactgatt attttagtca gcagttcctc    180
 taactttttt tcaagcttct tagttccttg cattgggtta gaacatgctc ctttagcttg    240
 aaagagtttg ttattatcca cctgatgaag cctacttctg tcaatttgtc taaccaattt    300
 tccatccagt tttgttccct tgctggtgag gagttgtaat cctttgcagg agaagagcca    360
 ttctggtttt tggaattttc agcctttttg cactagcttt tcctcatctt catggattta    420
 tctacctttg gtctttgatg ctggtgacct ttgcatgggg tttctgtgtg gacgtccttt    480
 ttgttgatgt tgatgcccct cn                                             502



      <210> 504
      <211> 423
      <212> DNA
      <213> Homo sapiens


      <400> 504
 gcggcggcgg cggcggcgga catggaacgc caagaggagt ctctgtccgc gcggccggcc     60
 ctggagaccg aggggctgcg cttcctgcac accacggagg gctccctgct ggccacctat    120
 ggctggaaca tcgtcttcag ctgcatcctt ctctacgtgg tctttcagaa gctttccgcc    180
 cggctaagag ccttgaggca taggcagctg gaccgagctg cggctgctgt ggaacctgat    240
 gttgatgtta aactacaaga agctttagca gctgctcgac tgaaaatgca agaagaacta    300
 aatgcgcaag ttgaaaagca taaggaaaaa ctgaaacaac ttgaataaga aaaaaggaga    360
 cagacgattg aaatgtggga cagcatgcaa gatggaaaaa gttactaagg aaatgcacag    420
 aag                                                                  423



      <210> 505
      <211> 2464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2464)
      <223> n = a,t,c or g


      <400> 505
 cgtggtgcag tccctggagg gttctcacgc tttggctgtc tggactttta agtttttccg     60
 ctttttcagg aaggcgaccg gcagcctcgg gcaggggaga caggactgta tgtcagagaa    120
 gagacggcgc ttggacgcca ggaatcctct gaagcaggag actgccctat ccaggttacc    180
 cttcccgagg ggaaaccagg gtctccttca gaaagctgag gcaggccggg cgcggtggct    240
 cacgcctgta atcccagcac tttggaagac cgaggcgggc ggatcacctg agcagaagat    300
 gactcaagac cggcctctgc ttgccgtgca ggaggcgctg aagaagtgct tccccgtggt    360
 ggaggagcag cagggcctgt ggcagagtgc cctgcgggac tgccagcccc tcctgtcctc    420
 cctcagcaac ctggcggaac agctgcaggc cgcacagaac ctgcggtttg aggatgtgcc    480
 ggcgcttcgg gccttcccag atttaaaaga gcggctgagg cgtaagcagc tggtggctgg    540
 tgacatcgtc ctggacaagc taggggaaag gctagccatc ctcctcaagg tgcgagacat    600
 ggtcagcagc catgtggagc gagtgtttca gatctatgag caacacgcag acacagttgg    660
 cattgatgct gtcctgcagc cttcagcagt gagcccctct gtggctgaca tgttggaatg    720
 gttgcaggat attgagagac attatcgaaa gtcgtacctg aagagaaagt atcttctttc    780
 gtctatccag tggggagact tggcaaacat acaagctttg cccaaggcct gggaccgaat    840
 ttcaaaagac gaacaccatg atcttgtaca agatatccta ttgaatgttt ccttcttcct    900
 ggaagagtaa ggaagctatg cgtatctgga gaccacgggt accacagttg aagactgaca    960
 ttctgaaccc tgatgtttct aaagaaacgt cagtatttca gtctgacata tttgaaacat   1020
 cagtgccttg aaccttagga ctgggtcttg gggaggatta gcgcctagat gtctgatttt   1080
 ggagctgcag catgccaggc cgtggctgag agtatgtgag ccatgccttg cccttttctg   1140
 aggctcaggg aagtggatgg agctagagag acaacaggaa agacggtgct gaagaacata   1200
 gtgtctttcc tctattgtgg acctaaagag gtggggaagc aaggacaaga ggcaaagagc   1260
 cacactgccc ttggcatcat ccaaagcatt gtctggttga caccaggtcc tggttttgtg   1320
 tcttttgtca atacctgaat ccttgacaaa agaaaaagtg gttttgatga tttaaagaaa   1380
 taagggtgat tttgacagaa aatatatttt aaaaattttg accaattgca atagttatcc   1440
 tcaagccaat ttccagaacc tgccaccagg gggaggtggt gcagcatgaa tcattctgaa   1500
 tgctttgtct ttgaagtgtt cccctattgc tgttaccatc tcagaggaag taactgggca   1560
 tggtgagact cctaaaatga caggagtttt tttggccaaa gctggcatct gacttgccac   1620
 attcctctga gtctggagta gccgcagggg tgggagaatg ccagcccaga gtcagtccat   1680
 cggggttaca tttccaaggt ctgctgcctt catctatgta atggccgtgt tactttcaga   1740
 tctttcagct tcccagagtg ttgtgggaat cttggtcatt gaatgtaaag ggacttagta   1800
 aagggtatag atatttttca aaaatgaaaa taactttttt tcttataagt gataagcttt   1860
 tataaagatc ataggaaaac tagaaaaaat gtaaaatgta gaaaattgta aaacaaactt   1920
 cattagagat attttgatag ataccttttc agtgtctatt tacaaannnn nnnnnnnnnn   1980
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn   2040
 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnca attcacaaat   2100
 ttttttaaag aacaaacgtg ctatcatcga tacatactgt taggttgtct ttttttaaaa   2160
 aacctaatgt aatttgttca tctttttata tctgtaaata tagctcaaca cagttatatt   2220
 ctttttgtga atgtattata tctacaattt accttttttc ttagatttta catgcatttt   2280
 cccaaatctt tgtgtttgcc tatctgtaaa cggtaataca ttctgattac aaaaaatgaa   2340
 aatgttacat agaaatgtac cgttatccat ctaccagata actattatta ataatgtgta   2400
 tttatttttc caggaattaa aaaacatcta tcatataagt attgcaaata aaacttaaaa   2460
 agca                                                                2464



      <210> 506
      <211> 314
      <212> DNA
      <213> Homo sapiens


      <400> 506
 gtgagccggg agtgtgcctc tgccgtccag cctgagcaac agagtgagaa ttccccagga     60
 gtgcagaggt tctcagaact gcaatactct gagatgaatt ttgaaagctc aagcaacagt    120
 ggggatcagc atcaacttgg attcgccttt tacaagtcca cctctcagag aagaaataat    180
 ggcaaataac ttttccttgg agagtcataa catatcactg actgaacatt ctagtatgcc    240
 agtagaaaac aatatcactt tagaaaggcc ttctaatgta aatctcacat gccagttcac    300
 aacatctggg gatt                                                      314



      <210> 507
      <211> 545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(545)
      <223> n = a,t,c or g


      <400> 507
 ataccatagc taacaatttc tactataaag ttaatataag ctagttactt tatcctaagt     60
 aggaanggac agacnnnnnn naattgacgc cntctttgac ggaccttaaa accggcncga    120
 cccacgcggn cggacagctt ttaaaggaaa aggngtactg agccttctga ctatgccttg    180
 ttttcttttg agatatatat tttcacagtc ttttctagat atattattgc tttaacttaa    240
 caaatcttag caatctctca atgccttttc acttattttt ttccaagtta tgattctttt    300
 tcctcacagc cttttttgtt ccatagcaat gagggtgtcc atttgataat tttaacaaac    360
 aatgtaagtt taaaattgag gctaaggtaa catgaaaaag cagggaatct caaactttat    420
 ttcatatata tacacacaca cacacacaca cacacacaca catacataca tatatatata    480
 tatacatata tatacataca cacatacata taattttttt tttttggaga gggagctcca    540
 ctctc                                                                545



      <210> 508
      <211> 379
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(379)
      <223> n = a,t,c or g


      <400> 508
 ngtgtggnna aactgaancc tggtacctca cggaagngcc gnggaattcg aacagcattc     60
 aaaattcccc gtcctgtcag ngnnnncctt cgcacccctg cttctctccg aggaggttga    120
 gctcttgagc aagttgggac ttgggccggg gcctggaaga atgattggct gggaggccgc    180
 gggagggagg ccaggaggcc cggaccagtt gggaggagtg agcaggcccc gggggagggg    240
 gatgagcgca gtttgctcgc tttcctcccc tgccggcccc ctccgccccc acacacactc    300
 gggacgtctt cattgaagat tcacttacaa aggaatgttt cactaaataa aagaaaacca    360
 gaaaaaaaaa aaaaaaaaa                                                 379



      <210> 509
      <211> 954
      <212> DNA
      <213> Homo sapiens


      <400> 509
 tttacaggat gatgaaacat ggtttcaaac gagttctttc ttgttacttt ttaaaatttc     60
 ttttttataa attaatattt tattgttgga tcctcctcct ttctctggag ctgtgcttgg    120
 ggctactctg acactctgtc tcttcatcac cagccaagga aaggggcttt cgggtagggc    180
 gtagctgcag ggcctccttg aagtacttgg gaaggaggaa gccatcagta ttccctggag    240
 tcagaatcac cccattggca gagcggaaga agggtattcc atctgccaga gccaggggtc    300
 catcgatgaa cacagctatt tcacaacggg accgcatgcc actgatgata ccggggtctc    360
 caggcagtcc tggggccagg tgaatgtgcg tccttccctg gcaggacagg cctttgagta    420
 ggatggatgg ccagtgcttc cagaatgtac catggactag catcgggggc agggcctgcg    480
 gtgtctccag gggcatcagc tccaacttag gtacctgcag ggaatggccc tggttggccc    540
 ggatgagaag gccagtgctg ggatccccca gctgcagggc gaaccgctgc ttcctattgg    600
 tgtccaccac gcgctgcaca tcttcagcag agaagccgcg gaactggggc aactgcagga    660
 gggtgcccag gggcacgaag ccatcagctc ccatgggaag ccccagcttc aaggccccat    720
 ggcgcagggc ataggacaga gccttggaca gctgcacgtc tcggtcctgt tctcggggtc    780
 tgggagccct tctacccctg gaccctgctg cttcctgcct ccctcctcca gagaagttca    840
 tggttaagac ccaaggtcac accgtcagcc aggagcgcag ggaggccgag ccccgcaccc    900
 cagatcgctg gtgcgccccg cagggtggtc cgggaggaat tccaccacac tgac          954



      <210> 510
      <211> 420
      <212> DNA
      <213> Homo sapiens


      <400> 510
 cacggcacgc gacttaagct aggatcctct acagcggacg caatacactc tggctatatt     60
 caaaacattt tctttctcat cacttgaagc cttcaagcct ggtggtttct cagaagacac    120
 tgtcctagat ttttctccat ccttgttttc tctggctata cccaaaacag aatcttcctc    180
 gtcacttgta cccttcaagg ttggtggttt ctgagaagac actttcctag atatttctcc    240
 atcctttttt cctctggtta tattcgaaaa agaatccttc tcatcacttg tagccttcaa    300
 ggctggtttt ttccgagaag acactctcct agttttttct ccattctttt ttcctctggc    360
 tatattcaaa agagaatctt tctcgtctct tgtagccttc aagcctggtg gttggtcaaa    420



      <210> 511
      <211> 1371
      <212> DNA
      <213> Homo sapiens


      <400> 511
 tttttttttt ttctgggaga acaatggctt tattcagatg ttggtgcctc tgcccctctg     60
 gtgcccccga tccccacaag gggccgcgag gcgggcaggt cacagcaggt tgaagtcccc    120
 tttgtgctgt tccagccact ggtccagcgt cagggccttg gggttgagtc tcagggtcag    180
 ctcgatgtca cggtcgggtc tcagggcata gaaacggaac atgttggcca ggtcccgggc    240
 accgggaaag ccaagctttt cgtagtcctc aggagtcatc ttggcatcgt gcacgacctt    300
 gcgggtgtgc ttggtgagca gggcagcgta ctcctcggcc gtgtgcctgc aagtgctcag    360
 cccgatgttc tggccgacgt atttttctgg catcttcaaa aggctgagca ccacaggacc    420
 caggtcagac acggacatgc catccatggg aacgtcacct gtgggcaagc tcagcaagta    480
 gctctttccg tctggggctt tctggggcaa gaagtgggag aggaggttct caaaatagca    540
 gggcagccgc acactggtca tgggaacgcc aatgtcccgg aaatattcct ccacctcccc    600
 tttgccgtca aagtgcgcgg cggccaatct ccctgccgtc agcttcttga tgttctccag    660
 gccgctgtag accacatagt ggaggcccag gcgcctggcc agatcagcga gcagcttccc    720
 ctgcttgacc tcctgctcct ggctgcagct ctcccagtaa ttggtcacga tgaaggtggc    780
 gtaagcccca ttcagggcca gctccatgat gacctggtca tcttggtctc cctgcactac    840
 ttctgcacct tgcagcctca gctcctttgc tgccttcttc ctagggtttc gggtcaccac    900
 tcgaaccttg aatgtcccat cttccaggag tgtgcgggcc acggagccac cctgggcacc    960
 tgtgcctccg aaaaccacca ccagtttctt gtccaccatg aggacgagaa tgggacgaat   1020
 ccggtccaga gatctggcag agcgccgctc acggaagccc agcgtcggag gacccctggc   1080
 tgcagccgcc aatcccgacg tgtcggccga aacccctcct ccggcgcagt tggctcctcc   1140
 tggatcccgc gggactcggc gtcgtttccg ggtttgcccg ccccaggcac gtgcacagtg   1200
 agtttgtgta aatccagtta gaccaaaatg agcgaggtgg agagcctctt aaccggatgc   1260
 tacgggtgat gacccgctga gcagagcctg agcctgcaac ctccagagat ctggggaaag   1320
 ccacatactc cgcttcccgc ccccctcgtg ccaagcaggg cgtaagcagg t            1371



      <210> 512
      <211> 2620
      <212> DNA
      <213> Homo sapiens


      <400> 512
 ggcacgaggc gcagctggac ccagcagccg ctgtctccag tgccgcagca gcaggtagtg     60
 ctcatagctc tctttgtcca gtgcttcggc cttggtccca gcgccttccc acggagcagc    120
 actcttcacc ctgcacagcc ttgttagccc aacagcatgg tggtggaaca ccccgagttc    180
 ctcaaggcag ggaaggagcc tggcctgcag atctggcgtg tggagaagtt cgatctggtg    240
 cccgtgccca ccaaccttta tggagacttc ttcacgggcg acgcctacgt catcctgaag    300
 acagtgcagc tgaggaacgg aaatctgcag tatgacctcc actactggct gggcaatgag    360
 tgcagccagg atgagagcgg ggcggccgcc atctttaccg tgcagctgga tgactacctg    420
 aacggccggg ccgtgcagca ccgtgaggtc cagggcttcg agtcggccac cttcctaggc    480
 tacttcaagt ctggcctgaa gtacaagaaa ggaggtgtgg catcaggatt caagcacgtg    540
 gtacccaacg aggtggtggt gcagagactc ttccaggtca aagggcggcg tgtggtccgt    600
 gccaccgagg tacctgtgtc ctgggagagc ttcaacaatg gcgactgctt catcctggac    660
 ctgggcaaca acatccacca gtggtgtggt tccaacagca atcggtatga aagactgaag    720
 gccacacagg tgtccaaggg catccgggac aacgagcgga gtggccgggc ccgagtgcac    780
 gtgtctgagg agggcactga gcccgaggcg atgctccagg tgctgggccc caagccggct    840
 ctgcctgcag gtaccgagga caccgccaag gaggatgcgg ccaaccgcaa gctggccaag    900
 ctctacaagg tctccaatgg tgcagggacc atgtccgtct ccctcgtggc tgatgagaac    960
 cccttcgccc agggggccct gaagtcagag gactgcttca tcctggacca cggcaaagat   1020
 gggaaaatct ttgtctggaa aggcaagcag gcaaacacgg aggagaggaa ggctgccctc   1080
 aaaacagcct ctgacttcat caccaagatg gactacccca agcagactca ggtctcggtc   1140
 cttcctgagg gcggtgagac cccactgttc aagcagttct tcaagaactg gcgggaccca   1200
 gaccagacag atggcctggg cttgtcctac ctttccagcc atatcgccaa cgtggagcgg   1260
 gtgcccttcg acgccgccac cctgcacacc tccactgcca tggccgccca gcacggcatg   1320
 gatgacgatg gcacaggcca gaaacagatc tggagaatcg aaggttccaa caaggtgccc   1380
 gtggaccctg ccacatatgg acagttctat ggaggcgaca gctacatcat tctgtacaac   1440
 taccgccatg gtggccgcca ggggcagata atctataact ggcagggtgc ccagtctacc   1500
 caggatgagg tcgctgcatc tgccatcctg actgctcagc tggatgagga gctgggaggt   1560
 acccctgtcc agagccgtgt ggtccaaggc aaggagcccg cccacctcat gagcctgttt   1620
 ggtgggaagc ccatgatcat ctacaagggc ggcacctccc gcgagggcgg gcagacagcc   1680
 cctgccagca cccgcctctt ccaggtccgc gccaacagcg ctggagccac ccgggctgtt   1740
 gaggtattgc ctaaggctgg tgcactgaac tccaacgatg cctttgttct gaaaaccccc   1800
 tcagccgcct acctgtgggt gggtacagga gccagcgagg cagagaagac gggggcccag   1860
 gagctgctca gggtgctgcg ggcccaacct gtgcaggtgg cagaaggcag cgagccagat   1920
 ggcttctggg aggccctggg cgggaaggct gcctaccgca catccccacg gctgaaggac   1980
 aagaagatgg atgcccatcc tcctcgcctc tttgcctgct ccaacaagat tggacgtttt   2040
 gtgatcgaag aggttcctgg tgagctcatg caggaagacc tggcaacgga tgacgtcatg   2100
 cttctggaca cctgggacca ggtctttgtc tgggttggaa aggattctca agaagaagaa   2160
 aagacagaag ccttgacttc tgctaagcgg tacatcgaga cggacccagc caatcgggat   2220
 cggcggacgc ccatcaccgt ggtgaagcaa ggctttgagc ctccctcctt tgtgggctgg   2280
 ttccttggct gggatgatga ttacctggtc tgtgggaccc cttggaacag ggcccatggc   2340
 tggagctggg ctgccttagg aggggcaggg cccccccatg tccccggtca agggcctttt   2400
 ggaactgtcc ttccctcaaa gaggccttag agcgagcaga gcagctttgc tatgagtgtg   2460
 tgtgtgtgtg tgtgtgtgtt gtttcttttt tttttttttt tacagtatcc aaaaatagcc   2520
 ctgcaaaaat tcagagtcct tgcaaaattg tctaaaatgt cagtgtttgg gaaattaaat   2580
 ccaataaaaa cattttgaag tgtgtactct aaaaaaaaaa                         2620



      <210> 513
      <211> 876
      <212> DNA
      <213> Homo sapiens


      <400> 513
 ggaaaatgtt acatcacatt tttttctata tagcagagtt tatgatagaa cttttaaggg     60
 ggagctcttt tatgtaatgc tggctattcc gaagttcgca aagtgctgag gccacggtga    120
 gcagtcttaa cagtggattg tctgcctaga tacgttccca gcggagaact taatgtaacc    180
 tactttcgtg cagctccgtg tgttaggatg atttttccct ttattaggaa ttcattattt    240
 tattattcat ttaattgcct tcttagttcc ctgggatccc ctccttggag ctaggagaat    300
 gaactttctt cagggagctc taccaaagaa agaagaccac tgtgtcttct cttaatttga    360
 aattgctttt tggtattttc accagcccgg agtactgtag gagagttcgc ttccatgtct    420
 tctgaggaat gcatctaaat gcatgtggta ttcctatttc cattaactct gtgtgtggtg    480
 tcgctgtagg agcgtcagga agcagagaaa atgttcaagg gcaaacgggg tgcacagctt    540
 gcaaaggata ttgccaggag aagcaaaacg taagacacgg atatccaact taactctact    600
 tcaccttcag aaacatgatc tgatctgtct ggcagttcgt ctcctacaaa attaaccaaa    660
 aactctgaca tattaatgtg gtattaaatt tgagtgctta tagtccatgt acatcaatgg    720
 tccacacatc acaagaaatt tctaccagct tagcagagca aatatttcag tagtcagtct    780
 tcatgtgata ccatgtacat cctattttct atataggaag atgaactgga tggtgtttct    840
 gaaggagaga gttcttgtat cagtttgtta acaaag                              876



      <210> 514
      <211> 2482
      <212> DNA
      <213> Homo sapiens


      <400> 514
 atgaactaca ggtaaaatct agaagaacat agataataaa aaatttctga tttaacagac     60
 atagtaaata taaatgaatt aactcacaca acctacttac accaaacaaa actagaatga    120
 acaacttgta ggaaccacct ctagttgatt tcaccactta acaggggcaa gatcttaggt    180
 ggatcatttt gtttaaggat gacttgaaat tttacaatac taccttagct cccacatatg    240
 aaaactcttc aagaattttt tctcatcaac cagacgttga ggaaaataca gtgagaaata    300
 aaatgaaacg gcttctcaca catatgaagg cccagatcac ccctaaattt ctagtgattt    360
 aacttaagaa gctccttgcc ctgagagatt cctttatccc acaacactct actcagaggg    420
 ggcagagaat cccaggacac tacacaagcc acaggataaa aacacaacct gtcttctatc    480
 tggcaccaac tgactaatat ctaggtatac acaggactga ctttaaagtt ggttaacaaa    540
 tattttaatt cattaaaata aaacttaaaa attacatgct tagtctacac aagtttaact    600
 tactttagtc acttagtgaa ttgtgaattg gctcccatta gtggtcagga gaatgtattt    660
 ggtgtagaaa ccaaataaat caagctatta tcgccgccgt gagtacaaaa caatgtttat    720
 ttgtttgtaa agtgccaggt ttatatttaa gtaaacatta aaatctgcgt tgaagcagtg    780
 aggctgcatc ttttaactgg ctgtgctggt taaaggactg tttaatcccg ctgtgctaag    840
 ctcactaaag ggtcacccct cacttttaaa gccaagactg ccattgtcac tgctatggta    900
 agtccacaag cccaacccag gccttctggg caaaaggtga atactaccag cactataaac    960
 agacaggact ggttgtgagg tagctacaca gttttaaaga tgctgttaat gaacattacg   1020
 gacaattcat ggtgtggcta gttggtaaca cttcagctga tttttcttat gagatggaaa   1080
 aaaaaaatca gccaagtaag ggcacatctt cagttcattt agaagtcagc atccaaggta   1140
 aaagaattct ctgttggact tgacatcact cccatcctct gatactcgcc tactctcttc   1200
 tcaaagaagt tagtctttcc ttccagtgaa atattctcca taaagtcaaa tgggttctct   1260
 actctgaaaa ccttgctaaa acccagttcc agcataagtc tgtctgccac aaactcaatg   1320
 tattgcttca ttagagtgca attcatccca atgagcttca caggcaaggc ctcagtgagg   1380
 aactcctgtt ctatccgaac agcattgata attatttctc ttactctctc ctccgatggt   1440
 ttgtgtacca ggtgtttgaa catcaggcaa gcaaaatcac agtgtaaacc ctcatctctg   1500
 ctaataagtt cattagaaaa tgtgaggcca ggcatcagtc ctcgtttctt gagccagaat   1560
 atcgacgcaa aagaaccgga aaagaaaatg ccttccactg cagcaaaggc tacaacacgt   1620
 tcaccatagg tagcctcttt gtccccaatc cagcgcaagg cccagtctgc cttcttcttg   1680
 acacaaggca tcgtttcaat ggcattgaag agaaattccc tttctttggg atcttttatg   1740
 taagtgtcaa taagaagact atacatttca gaatgtatgt tttccatggc aatttggaag   1800
 ccatagaaac agcgggcttc tgtaatctga acttcttggc taaatcgctc caccaagttt   1860
 tcatttacta tgccatcgct tgctgcaaag aaagccagaa catgggatat aaaatatctc   1920
 tcctcgggtt tcagggattc ccagtgctga atgtccttgg agaggtcaac ctcctcggcg   1980
 gtccaaaagg aagcctctgc cttcttatac atctgccaga tatcatggta ctcgatgggg   2040
 aagatgacaa agcggcgggg gttttctctc agcagcggct catcctccac gccgggggca   2100
 gctgctttag ttttcggctc cgtgggctcc tggaagatcc tcctcgcggt cttgctggcc   2160
 aggacgcggg tcccgctcag ggccggcggc gtgttctcct tgtcgaccaa gctgagcccc   2220
 ttcagcggcg agagctgcag ctgctgcggg tccgtgatgg gcgcgagcgg gacacggagg   2280
 gagagcatag tggaggcgca gcgaagcaga gcgagcagcc aggacaggac ggctgggaca   2340
 gggtgcacgg gcgacccctc actccagcag cctttaaatc tcccgcgccg cgcgctcccg   2400
 gcccttccca ttggctttgg tgccccggcc cttcccattg gctgtgccat gcctccgacc   2460
 cttcccattg gctgcgcctg gg                                            2482



      <210> 515
      <211> 930
      <212> DNA
      <213> Homo sapiens


      <400> 515
 gcacgagcgc gagttggact gtgaagaaac atggcggccg cgacgttgac ttcgaaattg     60
 tactccctgc tgttccgcag gacctccacc ttcgccctca ccatcatcgt gggcgtcatg    120
 ttcttcgagc gcgccttcga tcaaggcgcg gacgctatct acgaccacgt caacgagggg    180
 aagctgtgga aacacatcaa gcacaagtat gagaacaagt agttccttgg aggcccccat    240
 ccaggccaga aggaccaggt ccacccagca gctgtttgcc cagagctgga gcctcagctt    300
 gaagatgatg ctcaaggtac tcttcatgga ccaccattcg ctgttggcaa gaaacggctt    360
 tacttacaaa acagactctt taccttctgc tgtgtttgaa gtatgtttag tcagcatgct    420
 caggaaataa atgtgaattg cccttgagac ctgcttctac attggttgct ttgttaactc    480
 tacctgatct tcacttgtca gtaatttgag accacttcaa agccctctgc aaacacccca    540
 aaggcagaat ctgctatttt gagttttcca ttaacttcca aagaattctg gttttcaaaa    600
 caggagccag agttggagat attacagtca actttggctt ctaagccagt aattccattc    660
 ttaaatacct cactgtcttg gccatgggga agcactatgg cctcagctgg gggaaagacc    720
 ctggcctagg ggtcttagcc actccccacc ctagggtata gttcaggggt atccaatcct    780
 ttggcttccc tgggccatgt tggaagaatt gtcttgggcc acacataaaa tacagtaacc    840
 atagctgatg agctaaaaca aaaaacaatg gtttgtgcaa aaatctcata atgttttaat    900
 aaagttgaag aatttgaaaa aaaaaaaaaa                                     930



      <210> 516
      <211> 3083
      <212> DNA
      <213> Homo sapiens


      <400> 516
 cagtggcgga attctagcca ccggtgtctc cttctacatc cgcctctgcg ccggctgcca     60
 cccgcgctcc ctccgccgcc gccgccttgc tgctgctcaa agctgctgcc gccccttggg    120
 ctaaaaggtt ttcaaatgga acattttgat gcatcactta gtacctattt caaggcattg    180
 ctaggccctc gagatactag agtaaaagga tggtttcttc tggacaatta tatacccaca    240
 tttatctgct ctgtcatata tttactaatt gtatggctgg gaccaaaata catgaggaat    300
 aaacagccat tctcttgccg ggggatttta gtggtgtata accttggact cacactgctg    360
 tctctgtata tgttctgtga gttagtaaca ggagtatggg aaggcaaata caacttcttc    420
 tgtcagggca cacgcaccgc aggagaatca gatatgaaga ttatccgtgt cctctggtgg    480
 tactacttct ccaaactcat agaatttatg gacactttct tcttcatcct gcgcaagaac    540
 aaccaccaga tcacggtcct gcacgtctac caccatgcct cgatgctgaa catctggtgg    600
 tttgtgatga actgggtccc ctgcggccac tcttattttg gtgccacact taatagcttc    660
 atccacgtcc tcatgtactc ttactatggt ttgtcgtcag tcccttccat gcgtccatac    720
 ctctggtgga agaagtacat cactcagggg cagctgcttc agtttgtgct gacaatcatc    780
 cagaccagct gcggggtcat ctggccgtgc acattccctc ttggttggtt gtatttccag    840
 attggataca tgatttccct gattgctctc ttcacaaact tctacattca gacctacaac    900
 aagaaagggg cctcccgaag gaaagaccac ctgaaggacc accagaatgg gtccatggct    960
 gctgtgaatg gacacaccaa cagcttttca cccctggaaa acaatgtgaa gccaaggaag   1020
 ctgcggaagg attgaagtca aagaattgaa accctccaaa ccacgtcatc tgattgtaag   1080
 cacaatatga gttgtgcccc aatgctcgtt aacagctgct gtaactagtc tggcctacaa   1140
 tagtgtgatt catgtaggac ttctttcatc aattcaaaac ccctagaaaa cgtatacaga   1200
 ttatataagt agggataaga tttctaacat ttctgggctc tctgacccct gcgctagact   1260
 gtggaaaggg agtattatta tagtatacaa cactgctgtt gccttattag ttataacatg   1320
 ataggtgctg aattgtgatt cacaatttaa aaacactgta atccaaactt ttttttttaa   1380
 ctgtagatca tgcatgtgat tgtaaatgta aatttgtaca atgttgttat ggtagagaaa   1440
 cacacatgcc ttaaaattta aaaagcaggg cccaaagctt attagtttaa attagggtat   1500
 gtttccaagt ttgtatttaa gtttgtaata gctctgcttt agaaaaaaty maaagaccat   1560
 gatttatgaa actaatgtga cataatttcc agtgacttgt tgatgtgaaa tcagacacgg   1620
 caccttcagt tttgtactat tggctttgaa tcaagcaggc tcaaatctag tggaacagtc   1680
 agtttaactt tttaacagat cttatttttt tattttgagt gccactatta atgtaaaaag   1740
 gggggggctc tacagcagtc gtgatgaaac ttaaatatat attctttgtc ctcgagattt   1800
 taggaagggt gtagggtgag taggccattt ttaatttctg aagtgctaag tgtttttata   1860
 cagcaaacaa aaagtcaatt ttgctttcca ccagtgcgag agaggatgta tacttttcaa   1920
 gagagatgat tgcctattta ccgtttgaca gagtcccgta gatgagcaat ggggaactgg   1980
 ttgccagggt ctaaatttgg attgatttat gcactgttat ctgttttgac acagatttcc   2040
 ttgtaaaatg tgcctagttt accaaaatta acaaaggggg ggaaaggacc ttagaacttt   2100
 ttaaggtaaa atcaaatata gctacagcat aagagaatcg agaaatttga tagaggtaac   2160
 ttgtttaatg taaatctaat agtacttgta atttctttct gcttagaatc taaagatgtg   2220
 tttagaacct cttgtttaaa aataatagac tgcttatcat aaaatcacat ctcacacatt   2280
 tgaggcagtg gtcaaacagg taaagcctat gatgtgtgtc attttaaagt gtcggaattt   2340
 agcctctgaa taccttctcc attgggggaa agatattctt ggaaccactc atgacatatc   2400
 ttagaaggtc attgacaatg tataaactaa ttgttggttt gatatttatg taaatatcag   2460
 tttaccatgc tttaattttg cacattcgta ctatagggag cctattggtt ctctattagt   2520
 cttgtgggtt ttctgtttga aaaggagtca tggcatctgt ttacatttac cttatcaaac   2580
 ctagaatgtg tatatttata aatgtatgtc ttcattgcta ggtactaatt tgcagatgtc   2640
 tttacatatt tcaatacaga aactataaca ttcaatagtg tgctgtcaaa gtgtgcttag   2700
 ctcacctgga tatacctaca ttgttaaatg tctaaacagt aatcattaaa acatggtaaa   2760
 ctgatattta tgtaaatatc agtttaccat gctttaattt tgcacattcg tactataggg   2820
 agcctattgg ttctctatta gtcttgtggg ttttctgttt gaaaaggagt catggcatct   2880
 gtttacattt accttatcaa acctagaatg tgtatattta taaatgtatg tcttcattgc   2940
 taggtactaa tttgcagatg tctttacata tttcaataca gaaactataa cattcaatag   3000
 tgtgctgtca aagtgtgctt agctcacctg gatataccta cattgttaaa tgtctaaaca   3060
 gtaatcatta aaacattttt gat                                           3083



      <210> 517
      <211> 107
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(106)
      <223> Xaa = any amino acid or nothing 


      <400> 517
 Leu Lys Ile Pro Met Gln Phe Leu His Ser Gly Phe Trp Phe Ser Phe
   1               5                  10                  15    
 Phe Val Phe Phe Gly Phe Xaa Lys Phe Gly Phe Gly Pro Gln Gly Gly
              20                  25                  30        
 Arg Gln Gly Gly Asn Lys Thr Lys Gly Glu Lys Leu Pro Pro Gly Lys
          35                  40                  45            
 Lys Lys Ile Pro Gly Pro Asn Pro Gln Glu Asn Arg Glu Lys Lys Gly
      50                  55                  60                
 Pro Pro Lys Thr Leu Lys Lys Phe Gly Asn Leu Lys Lys Lys Gly Gly
  65                  70                  75                  80
 Lys Thr Arg Gly Pro Arg Gly Glu Lys Asn Ser Asp Pro Lys Gly Thr
                  85                  90                  95    
 Pro Gly Gln Asn Pro Gly Asn Lys Lys Lys
             100                 105    



      <210> 518
      <211> 110
      <212> PRT
      <213> Homo sapiens


      <400> 518
 Val Val Val Ala Pro Val Val Val Gly Ser Gly Arg Ala Pro Arg His
   1               5                  10                  15    
 Pro Ala Pro Ala Ala Met His Ser Arg Arg Pro Asp Gly Phe Asp Gly
              20                  25                  30        
 Leu Gly Tyr Arg Gly Gly Ala Arg Asp Glu Gln Gly Phe Gly Gly Ala
          35                  40                  45            
 Phe Pro Ala Arg Ser Phe Ile Thr Gly Ser Asp Leu Gly His Trp Val
      50                  55                  60                
 Thr Thr Leu Thr Asp Ile Pro Gly Arg Arg Asn Leu His Trp Gly Val
  65                  70                  75                  80
 Lys Ser Pro Pro Tyr Gly Val Pro Thr Asn Cys Thr Pro Tyr Glu Gly
                  85                  90                  95    
 Pro Thr Glu Asp Pro Phe Asp Ser Gly Ser Gly
             100                 105        



      <210> 519
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 519
 Asp Gly Phe Pro Leu Ser Phe Tyr Asn Thr Pro Lys Ser Pro Thr Ser
   1               5                  10                  15    
 Glu Ile Leu Phe Pro Leu Ser Glu Ile Leu Phe Ser Gly Pro Phe Gly
              20                  25                  30        
 Trp Leu Ala Ala Pro Ser Cys Phe Gly Phe Ser Cys His Phe Leu Lys
          35                  40                  45            
 Lys Gly Phe Leu Gly Pro Gly Thr Val Ala His Ser Cys Asn Pro Ser
      50                  55                  60                
 Thr Leu Gly Gly Arg Gly Gly Trp Ile Thr Arg Gly Gln Glu Ile Lys
  65                  70                  75                  80
 Thr Ile Leu Ala Asn Thr Val Lys Pro
                  85                



      <210> 520
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 520
 Gly Pro Leu Arg Val Asp Thr Trp Ser Asn Val Glu Ser Leu Ala Cys
   1               5                  10                  15    
 Ala Gln Arg Glu Glu Glu Glu Glu Asn Glu Arg Lys Lys Leu Pro Gly
              20                  25                  30        
 Thr Ala Ser Pro Glu Lys Lys Gln Glu Leu Val Asp Glu Pro Ala Val
          35                  40                  45            
 Gly Glu Ser Lys Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp
      50                  55                  60                
 Gly Glu Ser Pro Pro Ala Ser Lys Ile Asn Met Asp Ala Leu Gln Pro
  65                  70                  75                  80
 Asn Glu Asn Glu Asp Lys Ser Pro Tyr Pro Thr Pro Glu Ser Thr Gly
                  85                  90                  95    
 Glu Glu Asp Glu Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg
             100                 105                 110        
 Pro Leu Ser Glu Leu His Leu Lys Glu Lys Thr Val Pro Met Pro Glu
         115                 120                 125            
 Ala Ser Ala Cys
     130        



      <210> 521
      <211> 150
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(150)
      <223> Xaa = any amino acid or nothing 


      <400> 521
 Lys Ile Asn Thr Glu Leu Gln Thr Glu Val Ala Met Leu Lys Ser Met
   1               5                  10                  15    
 Val Leu Trp Leu Gly Glu Gln Val Gln Ser Leu Gln Leu Gln Gln Gln
              20                  25                  30        
 Leu Arg His His Phe Asn His Ile His Ile Cys Val Thr Asn Ser Glu
          35                  40                  45            
 Tyr Asn Gln Ser Glu Tyr Pro Trp Asp Leu Val Lys Ala His Leu Gln
      50                  55                  60                
 Gly Ala Phe Thr Ser Asn Ile Thr Phe Asp Thr Gly Glu Phe Gln Asn
  65                  70                  75                  80
 Thr Ile Ile Asp Ser Thr Lys Xaa Pro His Asp Leu Xaa Ala Ser Leu
                  85                  90                  95    
 Asp Asp Cys Ser Xaa Ile Xaa Asp Gly Leu Ser Ile Leu Ala Ser Val
             100                 105                 110        
 Leu Met Leu Ala Ala Pro Val Leu Ala Leu Gln Thr Pro Ser Trp Met
         115                 120                 125            
 Leu Phe Met Ala Leu Pro Val Ser Leu Ser Arg Leu Lys Ala Tyr Phe
     130                 135                 140                
 Leu Val Ser Val Leu Ser
 145                 150



      <210> 522
      <211> 65
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(65)
      <223> Xaa = any amino acid or nothing 


      <400> 522
 Ile Phe Trp Val Gly Lys Asn Ala Leu His Glu Asp Glu Xaa Asn Thr
   1               5                  10                  15    
 Glu Arg Arg Thr Asp Asp Ile Pro Val Trp Asp His Glu Phe Leu Lys
              20                  25                  30        
 Val Asp Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu
          35                  40                  45            
 Tyr Ile Arg Gly Trp Leu Asp Val Thr Cys Lys Thr Gly Ala Asn Met
      50                  55                  60                
 Ile
  65



      <210> 523
      <211> 147
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(147)
      <223> Xaa = any amino acid or nothing 


      <400> 523
 Tyr Ala Arg Ser Ala Ile Gly Leu Leu Val Phe Gln Ser Leu Met Leu
   1               5                  10                  15    
 Val Ala Ala Gly Asp Gln Phe Leu Phe Arg Pro Xaa Gly Glu Xaa Arg
              20                  25                  30        
 Gln Pro Arg Xaa Xaa Leu Lys Met Thr Lys His Pro Pro Asn Arg Arg
          35                  40                  45            
 Gly Ile Ser Phe Glu Val Gly Ala Gln Leu Glu Ala Arg Asp Arg Leu
      50                  55                  60                
 Lys Asn Trp Tyr Pro Ala His Ile Glu Asp Ile Asp Tyr Glu Glu Gly
  65                  70                  75                  80
 Lys Val Leu Ile His Phe Lys Arg Trp Asn His Arg Tyr Asp Glu Trp
                  85                  90                  95    
 Phe Cys Trp Asp Ser Pro Tyr Leu Arg Pro Leu Glu Lys Ile Gln Leu
             100                 105                 110        
 Arg Lys Glu Gly Leu His Glu Glu Asp Gly Ser Ser Val Ser Asn Lys
         115                 120                 125            
 Ser Gly Lys Phe Cys Ser Met Gln Gly Gln Pro Leu Gly Cys Leu Cys
     130                 135                 140                
 Phe Asn Leu
 145        



      <210> 524
      <211> 103
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(103)
      <223> Xaa = any amino acid or nothing 


      <400> 524
 Lys Leu Phe Leu Gly Phe Pro Ile Leu His Gly Ser Ser Ser Pro Pro
   1               5                  10                  15    
 Xaa Leu Lys Val Pro Ser Leu Thr His Lys Val Ser Ala Leu Val Ser
              20                  25                  30        
 Ser Asn Ser Phe Xaa Val Met Tyr Leu Val Ile Phe His Met Asn Met
          35                  40                  45            
 Lys Val Ala Trp Arg Arg Gly Ser Leu Leu His Ser Phe Gln Leu Gly
      50                  55                  60                
 Phe Tyr Lys Ser Gln His Phe Gly Arg Pro Arg Trp Ala Asp Arg Leu
  65                  70                  75                  80
 Arg Leu Gly Val Arg Asp Gln Pro Gly Gln His Gly Glu Thr Pro Ser
                  85                  90                  95    
 Leu Leu Val Gln Lys Lys Ile
             100            



      <210> 525
      <211> 66
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(66)
      <223> Xaa = any amino acid or nothing 


      <400> 525
 Gly Pro Lys Pro Phe Ser Leu Gly His Lys Gly Lys Ser Cys Val Lys
   1               5                  10                  15    
 Lys Asn Phe Phe Phe Phe Phe Gly Gly Ser His Leu Xaa Met Gln Leu
              20                  25                  30        
 Leu Arg Arg Leu Arg Trp Glu Asp Gln Leu Ser Ser Gly Gly Arg Gly
          35                  40                  45            
 Cys Ser Gly Pro Xaa Leu His His Cys Thr Val Ala Trp Ala Thr Glu
      50                  55                  60                
 Gln Asp
  65    



      <210> 526
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 526
 Val Phe Thr Gly Asn Tyr Asn Ser Lys Met Arg Ile Trp Val Gly Thr
   1               5                  10                  15    
 Gln Pro Asn His Ile Ser Ala His Pro His Trp Val Met Val Ile Ser
              20                  25                  30        
 Val Ser Ser Arg Asn Ala Leu Ile Asp Met Pro Arg Asn Pro Cys Leu
          35                  40                  45            
 Thr Ser Cys Val Cys Leu Ser Ile Gln Ser Ser Arg Arg Leu Arg Leu
      50                  55                  60                
 Thr Ile Arg Ile Phe Met Pro Asp Ser Trp Leu Lys Ser Cys Leu Thr
  65                  70                  75                  80
 Ser Tyr Val Cys Leu Ser Ile Gln Ser Ser Arg Cys Leu Arg Leu Thr
                  85                  90                  95    
 Ile Arg Ile Phe Met Pro Asp Ser Trp Leu Lys Ser Cys Leu Thr Ser
             100                 105                 110        
 Tyr Val Cys Leu Ser Ile Gln Ser Ser Arg Arg Leu Gln Leu Thr Ile
         115                 120                 125            
 Arg Ile Phe Met Pro Asp Ser Trp Leu Lys Ser Cys Leu Thr Ser Tyr
     130                 135                 140                
 Val Cys Leu Ser Ile Gln Ser Ser Arg Cys Leu Gln Leu Thr Ile Arg
 145                 150                 155                 160
 Ile Phe Met Pro Asp Ser Trp Leu Lys Ser Cys Leu Thr Ser Tyr Val
                 165                 170                 175    
 Cys Leu Leu Ile Gln Ser Ser Arg Cys Leu Lys Leu Thr Val Arg Ile
             180                 185                 190        
 Phe Met Pro Leu Val Pro Arg Leu Ala
         195                 200    



      <210> 527
      <211> 203
      <212> PRT
      <213> Homo sapiens


      <400> 527
 Ser Arg Met Thr Lys Lys Arg Lys Arg Gln His Asp Phe Gln Lys Val
   1               5                  10                  15    
 Lys Leu Lys Val Gly Lys Lys Lys Pro Lys Leu Gln Asn Ala Thr Pro
              20                  25                  30        
 Thr Asn Phe Lys Thr Lys Thr Ile His Leu Pro Glu Gln Leu Lys Glu
          35                  40                  45            
 Asp Gly Thr Leu Pro Thr Asn Asn Arg Lys Leu Asn Ile Lys Asp Leu
      50                  55                  60                
 Leu Ser Gln Met His His Tyr Asn Ala Gly Val Lys Gln Arg Ala Leu
  65                  70                  75                  80
 Leu Gly Leu Lys Asp Leu Leu Ser Gln Tyr Pro Phe Ile Ile Asp Ala
                  85                  90                  95    
 His Leu Leu Asn Ile Leu Ser Glu Val Thr Ala Val Phe Thr Asp Lys
             100                 105                 110        
 Asp Ala Asn Val Arg Leu Ala Ala Val Gln Leu Leu Gln Phe Leu Ala
         115                 120                 125            
 Pro Lys Ile Arg Ala Glu Gln Ile Ser Pro Phe Phe Pro Leu Val Ser
     130                 135                 140                
 Ala His Leu Ser Ser Ala Met Thr His Ile Thr Glu Gly Ile Gln Glu
 145                 150                 155                 160
 Asp Ser Leu Lys Val Leu Asp Ile Leu Leu Glu Gln Tyr Pro Ala Leu
                 165                 170                 175    
 Ile Thr Gly Arg Ser Ser Ile Leu Leu Lys Asn Phe Val Glu Leu Ile
             180                 185                 190        
 Ser His Gln Gln Leu Ser Lys Gly Leu Asp Lys
         195                 200            



      <210> 528
      <211> 84
      <212> PRT
      <213> Homo sapiens


      <400> 528
 Trp Leu Pro Gly Glu Met Ala Val Glu Pro Pro Ala Asp Arg Leu Gln
   1               5                  10                  15    
 Glu Pro Leu Thr Phe Arg Asp Gly Ala Glu Asp Phe Thr Gln Glu Glu
              20                  25                  30        
 Trp Gly Gln Leu Asp Pro Thr Gln Arg Ile Leu Tyr Arg Asp Val Met
          35                  40                  45            
 Leu Glu Thr Phe Asp His Leu Leu Ser Ile Gly Pro Glu Leu Thr Lys
      50                  55                  60                
 Pro Glu Asp Ile Ser Gln Leu Glu Gln Gly Thr Asp Leu Trp Val Ala
  65                  70                  75                  80
 Glu Thr Leu Thr
                



      <210> 529
      <211> 135
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(134)
      <223> Xaa = any amino acid or nothing 


      <400> 529
 Ala Val Gly Gly Ser Ser Arg Ser His Gly Tyr Arg Arg Pro Ala Gly
   1               5                  10                  15    
 Thr Arg Pro Val Ser His Ala Gln Asp Pro Ser Ala Pro Pro Pro Ala
              20                  25                  30        
 Ser Arg Leu Pro Cys Ile Glu Ala Arg Gly Gly Gln Xaa Ser Leu Pro
          35                  40                  45            
 Ser Leu Ile Leu Gln Pro Gly Gly Ala Gly Trp Gly Ile Leu Leu Pro
      50                  55                  60                
 Asn Ser Val Leu Pro Pro Ala Pro Cys Thr Pro Gln Ser His Val Ser
  65                  70                  75                  80
 Leu Pro Ser Ala Gly Pro Cys Ala Pro Leu Gly Gly Arg Arg Gln Ala
                  85                  90                  95    
 Pro Leu Gly Pro Arg Ala Ala Glu Pro Cys Arg Val Arg Gly Cys Gly
             100                 105                 110        
 Ala Ala Ala Leu Ser Cys Ala Leu Pro Ala Leu Gly Arg Gly Thr Phe
         115                 120                 125            
 Gly Trp Lys Thr Gly Ile
     130                



      <210> 530
      <211> 359
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(357)
      <223> Xaa = any amino acid or nothing 


      <400> 530
 Val Arg Cys Thr Leu Ser Pro Ala Cys Gln Thr Pro Pro Gln Gly Pro
   1               5                  10                  15    
 His Arg Ser Ser Gly Pro Val Leu Ser Ser Pro Cys Pro Ala Pro Val
              20                  25                  30        
 Gly Glu Trp Leu Pro Pro Asn Gly Pro Xaa Ser Asp Asp Glu Leu Pro
          35                  40                  45            
 Leu Ser Gln Gln Cys Lys Cys Arg Thr Lys Ser Leu Ala Pro Pro Ser
      50                  55                  60                
 Ser Ala Xaa Gly Ser Xaa His Arg Thr Xaa Leu Pro Gly Thr Gly His
  65                  70                  75                  80
 Xaa Cys Gly Leu Ala Arg Ile Glu Ser Ser Ala Gly Val Leu Glu Glu
                  85                  90                  95    
 Ala Ser Ala Ala Lys Xaa Gly Ser Gly Glu Ala Pro Gly Ser Lys Gln
             100                 105                 110        
 His Ser Ser Ser Pro Ala Ala Thr Ser Ala Pro Ser Ala Gly Ser Trp
         115                 120                 125            
 His Pro Gly Thr Ala Ala Ala His Pro Pro Gly Ser Ser Ala Ser Phe
     130                 135                 140                
 His Thr Phe Ala Ala Phe Thr Val Ser Leu Ser Ala Ser Glu Leu Gly
 145                 150                 155                 160
 Ser Xaa Xaa Gln Ser Arg Val Lys His Phe Phe Leu Ser Cys Ser Ser
                 165                 170                 175    
 Thr Ser Cys Cys Ser Arg Ala Leu Ile His Thr Lys Ser Ser Glu Ser
             180                 185                 190        
 Gly Met Ser Ser Arg Arg Ser Ala Phe Ser Ser Pro Ser Ser Gly Gly
         195                 200                 205            
 Ile Ser Leu Ser Trp Leu Gly Pro Lys Ser Arg Ile Ser Ser Val Thr
     210                 215                 220                
 Ser Ser Arg Cys Ser Arg Val Ser Xaa Asn Phe Leu Ser Ser Glu Val
 225                 230                 235                 240
 Thr Phe Val Ser Val Ser Ser His Ser Ser Pro Gln Ala Thr Leu Glu
                 245                 250                 255    
 Xaa Leu Cys Val Lys Ser Gln Thr Ser Thr Met Leu Ser Tyr Ala Val
             260                 265                 270        
 Glu Leu Pro Ser Met Pro Glu Pro Ala Pro Leu Leu Gly Xaa Gly Leu
         275                 280                 285            
 Ser His Ser His Pro His Ala Val Arg Asp Ser Gly Glu Ala Cys Xaa
     290                 295                 300                
 Ser Met Gly Ser Val Thr Gly Pro Leu Tyr Ser Gly Tyr Lys Glu Glu
 305                 310                 315                 320
 Val Val Cys Cys Thr Leu Val Glu Val Phe Pro Ser Leu Leu Gln Val
                 325                 330                 335    
 Ser Arg Asn Pro Arg Met Pro Phe Asp Phe Leu Gly Ile Leu Ile Cys
             340                 345                 350        
 Thr Pro Trp Gly Ser
         355        



      <210> 531
      <211> 78
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(77)
      <223> Xaa = any amino acid or nothing 


      <400> 531
 Cys Ala Lys Asn Glu Cys Gln Gly Gly Gln Val Glu Ser Gly Ser Phe
   1               5                  10                  15    
 Xaa Ala Ile Tyr Leu Xaa Thr Val Ile Tyr Leu Cys Val Tyr Leu Ser
              20                  25                  30        
 Val Cys Leu Ser Ile Tyr Leu Ser Val Tyr Leu Ser Ile Tyr Leu Ser
          35                  40                  45            
 Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Pro Ser Ile His Pro Ser
      50                  55                  60                
 Ile Gln Leu Ala Ser Ile Xaa Ser Ile Phe Leu Trp Gly
  65                  70                  75        



      <210> 532
      <211> 283
      <212> PRT
      <213> Homo sapiens


      <400> 532
 Arg Lys Met Ala Gly Ser Pro Glu Leu Val Val Leu Asp Pro Pro Trp
   1               5                  10                  15    
 Asp Lys Glu Leu Ala Ala Gly Thr Glu Ser Gln Ala Leu Val Ser Ala
              20                  25                  30        
 Thr Pro Arg Glu Asp Phe Arg Val Arg Cys Thr Ser Lys Arg Ala Val
          35                  40                  45            
 Thr Glu Met Leu Gln Leu Cys Gly Arg Phe Val Gln Lys Leu Gly Asp
      50                  55                  60                
 Ala Leu Pro Glu Glu Ile Arg Glu Pro Ala Leu Arg Asp Ala Gln Trp
  65                  70                  75                  80
 Thr Phe Glu Ser Ala Val Gln Glu Asn Ile Ser Ile Asn Gly Gln Ala
                  85                  90                  95    
 Trp Gln Glu Ala Ser Asp Asn Cys Phe Met Asp Ser Asp Ile Lys Val
             100                 105                 110        
 Leu Glu Asp Gln Phe Asp Glu Ile Ile Val Asp Ile Ala Thr Lys Arg
         115                 120                 125            
 Lys Gln Tyr Pro Arg Lys Ile Leu Glu Cys Val Ile Lys Thr Ile Lys
     130                 135                 140                
 Ala Lys Gln Glu Ile Leu Lys Gln Tyr His Pro Val Val His Pro Leu
 145                 150                 155                 160
 Asp Leu Lys Tyr Asp Pro Asp Pro Ala Pro His Met Glu Asn Leu Lys
                 165                 170                 175    
 Cys Arg Gly Glu Thr Val Ala Lys Glu Ile Ser Glu Ala Met Lys Ser
             180                 185                 190        
 Leu Pro Ala Leu Ile Glu Gln Gly Glu Gly Phe Ser Gln Val Leu Arg
         195                 200                 205            
 Met Gln Pro Val Ile His Leu Gln Arg Ile His Gln Glu Val Phe Ser
     210                 215                 220                
 Ser Cys His Arg Lys Pro Asp Ala Lys Pro Glu Asn Phe Ile Thr Gln
 225                 230                 235                 240
 Ile Glu Thr Thr Pro Thr Glu Thr Ala Ser Arg Lys Thr Ser Asp Val
                 245                 250                 255    
 Val Leu Lys Arg Lys Gln Thr Lys Asp Cys Pro Gln Arg Lys Trp Tyr
             260                 265                 270        
 Pro Leu Arg Pro Lys Lys Ile Asn Leu Asp Thr
         275                 280            



      <210> 533
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 533
 Asp Cys Lys Asn Arg Asn Cys Ser Lys Gly Asp Ser Val Pro Met His
   1               5                  10                  15    
 Gln Gln Lys Arg Gln Pro Glu Leu Val Glu Gly Asn Leu Pro Val Phe
              20                  25                  30        
 Val Phe Pro Thr Glu Leu Ile Phe Tyr Ala Asp Asp Gln Ser Thr His
          35                  40                  45            
 Lys Gln Val Leu Thr Leu Tyr Asn Pro Tyr Glu Phe Ala Leu Lys Phe
      50                  55                  60                
 Lys Val Leu Cys Thr Thr Pro Asn Lys Tyr Val Val Val Asp Ala Ala
  65                  70                  75                  80
 Gly Ala Val Lys Pro Gln Cys Cys Val Asp Ile Val Ile Arg His Arg
                  85                  90                  95    
 Asp Val Arg Ser Cys His Tyr Gly Val Ile Asp Lys Phe Arg Leu Gln
             100                 105                 110        
 Val Ser Glu Gln Ser Gln Arg Lys Ala Leu Gly Arg Lys Glu Val Val
         115                 120                 125            
 Ala Thr Leu Leu Pro Ser Ala Lys Glu Gln Gln Lys Glu Glu Glu Glu
     130                 135                 140                
 Lys Arg Leu Lys Glu His Leu Thr Glu Ser Leu Phe Phe Glu Gln Ser
 145                 150                 155                 160
 Phe Gln Pro Glu Asn Arg Ala Val Ser Ser Gly Pro Ser Leu Leu Thr
                 165                 170                 175    
 Val Phe Leu Gly Val Val Cys Ile Ala Ala Leu Met Leu Pro Thr Leu
             180                 185                 190        
 Gly Asp Val Glu Ser Leu Val Pro Leu Tyr Leu His Leu Ser Val Asn
         195                 200                 205            
 Gln Lys Leu Val Ala Ala Tyr Ile Leu Gly Leu Ile Thr Met Ala Ile
     210                 215                 220                
 Leu Arg Thr
 225        



      <210> 534
      <211> 475
      <212> PRT
      <213> Homo sapiens


      <400> 534
 Ser Met Ile Ser Phe Cys Pro Asp Cys Gly Lys Ser Ile Gln Ala Ala
   1               5                  10                  15    
 Phe Lys Phe Cys Pro Tyr Cys Gly Asn Ser Leu Pro Val Glu Glu His
              20                  25                  30        
 Val Gly Ser Gln Thr Phe Val Asn Pro His Val Ser Ser Phe Gln Gly
          35                  40                  45            
 Ser Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val
      50                  55                  60                
 Lys Trp Ser Ser Thr Val Thr Ser Pro Arg Leu Ser Leu Phe Ser Asp
  65                  70                  75                  80
 Gly Asp Ser Ser Glu Ser Glu Asp Thr Leu Ser Ser Ser Glu Arg Ser
                  85                  90                  95    
 Lys Gly Ser Gly Ser Arg Pro Pro Thr Pro Lys Ser Ser Pro Gln Lys
             100                 105                 110        
 Thr Arg Lys Ser Pro Gln Val Thr Arg Gly Ser Pro Gln Lys Thr Ser
         115                 120                 125            
 Cys Ser Pro Gln Lys Thr Arg Gln Ser Pro Gln Thr Leu Lys Arg Ser
     130                 135                 140                
 Arg Val Thr Thr Ser Leu Glu Ala Leu Pro Thr Gly Thr Val Leu Thr
 145                 150                 155                 160
 Asp Lys Ser Gly Arg Gln Trp Lys Leu Lys Ser Phe Gln Thr Arg Asp
                 165                 170                 175    
 Asn Gln Gly Ile Leu Tyr Glu Ala Ala Pro Thr Ser Thr Leu Thr Cys
             180                 185                 190        
 Asp Ser Gly Pro Gln Lys Gln Lys Phe Ser Leu Lys Leu Asp Ala Lys
         195                 200                 205            
 Asp Gly Arg Leu Phe Asn Glu Gln Asn Phe Phe Gln Arg Ala Ala Lys
     210                 215                 220                
 Pro Leu Gln Val Asn Lys Trp Lys Lys Leu Tyr Ser Thr Pro Leu Leu
 225                 230                 235                 240
 Ala Ile Pro Thr Cys Met Gly Phe Gly Val His Gln Asp Lys Tyr Arg
                 245                 250                 255    
 Phe Leu Val Leu Pro Ser Leu Gly Arg Ser Leu Gln Ser Ala Leu Asp
             260                 265                 270        
 Val Ser Pro Lys His Val Leu Ser Glu Arg Ser Val Leu Gln Val Ala
         275                 280                 285            
 Cys Arg Leu Leu Asp Ala Leu Glu Phe Leu His Glu Asn Glu Tyr Val
     290                 295                 300                
 His Gly Asn Val Thr Ala Glu Asn Ile Phe Val Asp Pro Glu Asp Gln
 305                 310                 315                 320
 Ser Gln Val Thr Leu Ala Gly Tyr Gly Phe Ala Phe Arg Tyr Cys Pro
                 325                 330                 335    
 Ser Gly Lys His Val Ala Tyr Val Glu Gly Ser Arg Ser Pro His Glu
             340                 345                 350        
 Gly Asp Leu Glu Phe Ile Ser Met Asp Leu His Lys Gly Cys Gly Pro
         355                 360                 365            
 Ser Arg Arg Ser Asp Leu Gln Ser Leu Gly Tyr Cys Met Leu Lys Trp
     370                 375                 380                
 Leu Tyr Gly Phe Leu Pro Trp Thr Asn Cys Leu Pro Asn Thr Glu Asp
 385                 390                 395                 400
 Ile Met Lys Gln Lys Gln Lys Phe Val Asp Lys Pro Gly Pro Phe Val
                 405                 410                 415    
 Gly Pro Cys Gly His Trp Ile Arg Pro Ser Glu Thr Leu Gln Lys Tyr
             420                 425                 430        
 Leu Lys Val Val Met Ala Leu Thr Tyr Glu Glu Lys Pro Pro Tyr Ala
         435                 440                 445            
 Met Leu Arg Asn Asn Leu Glu Ala Leu Leu Gln Asp Leu Arg Val Ser
     450                 455                 460                
 Pro Tyr Asp Pro Ile Gly Leu Pro Met Val Pro
 465                 470                 475



      <210> 535
      <211> 306
      <212> PRT
      <213> Homo sapiens


      <400> 535
 Ala Glu Cys Glu Glu Val Arg Arg Lys Ser Glu Leu Phe Asn Pro Val
   1               5                  10                  15    
 Ser Leu Asp Cys Lys Leu Arg Gln Lys Ala Ile Ala Glu Val Asp Val
              20                  25                  30        
 Gly Thr Asp Lys Ala Gln Asn Ser Asp Pro Ile Leu Asp Thr Ser Ser
          35                  40                  45            
 Leu Val Pro Gly Cys Ser Ser Val Asp Asn Ile Lys Ser Ser Gln Thr
      50                  55                  60                
 Ser Gln Asn Gln Gly Leu Gly Arg Pro Thr Leu Glu Gly Asp Glu Glu
  65                  70                  75                  80
 Thr Ser Glu Val Glu Tyr Thr Val Asn Lys Gly Pro Ala Ser Ser Asn
                  85                  90                  95    
 Arg Asp Arg Val Pro Pro Ser Ser Glu Ala Ser Glu His His Pro Arg
             100                 105                 110        
 His Arg Val Ser Ser Gln Ala Glu Asp Thr Ser Ser Ser Phe Asp Asn
         115                 120                 125            
 Leu Phe Ile Asp Arg Leu Gln Arg Ile Thr Ile Ala Asp Gln Gly Glu
     130                 135                 140                
 Gln Gln Ser Glu Glu Asn Ala Ser Thr Lys Asn Leu Thr Gly Leu Ser
 145                 150                 155                 160
 Ser Gly Thr Glu Lys Lys Pro His Tyr Met Glu Val Leu Glu Met Arg
                 165                 170                 175    
 Ala Lys Asn Pro Val Pro Gln Leu Arg Lys Phe Lys Thr Asn Val Leu
             180                 185                 190        
 Pro Phe Arg Gln Asn Asp Ser Ser Ser His Cys Gln Lys Ser Gly Ser
         195                 200                 205            
 Pro Ile Ser Ser Glu Glu Arg Arg Arg Arg Asp Lys Gln His Leu Asp
     210                 215                 220                
 Asp Ile Thr Ala Ala Arg Leu Leu Pro Leu His His Met Pro Thr Gln
 225                 230                 235                 240
 Leu Leu Ser Ile Glu Glu Ser Leu Ala Leu Gln Lys Gln Gln Lys Gln
                 245                 250                 255    
 Asn Tyr Glu Glu Met Gln Ala Lys Leu Ala Ala Gln Lys Leu Ala Glu
             260                 265                 270        
 Arg Leu Asn Ile Lys Met Arg Ser Tyr Asn Pro Glu Gly Glu Ser Ser
         275                 280                 285            
 Gly Arg Tyr Arg Glu Val Arg Asp Glu Asp Asp Asp Trp Ser Ser Asp
     290                 295                 300                
 Glu Phe
 305    



      <210> 536
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 536
 Thr Leu Glu Phe Glu Ser His Ile Ile Phe Met Ser His Arg Ile Phe
   1               5                  10                  15    
 Phe Phe Cys Tyr Leu Lys Ala Lys Ile Lys Ile Leu Gly Trp Ala Arg
              20                  25                  30        
 Trp Leu Val Pro Val Ile Pro Ala Leu Trp Glu Ala Glu Val Gly Arg
          35                  40                  45            
 Ser Phe Glu Ala Arg Ser Ser Arg Thr Ala Trp Ala Thr Tyr Gly Gly
      50                  55                  60                
 Ser Leu Phe Tyr Lys Lys
  65                  70



      <210> 537
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 537
 Lys Met Ala Cys Asn Ile Pro Asn Gln Arg Gln Arg Thr Leu Ser Thr
   1               5                  10                  15    
 Thr Gly Glu Ala Leu Tyr Glu Ile Leu Gly Leu His Lys Gly Ala Ser
              20                  25                  30        
 Asn Glu Glu Ile Lys Lys Thr Tyr Arg Lys Leu Ala Leu Lys His His
          35                  40                  45            
 Pro Asp Lys Asn Pro Asp Asp Pro Ala Ala Thr Glu Lys Phe Lys Glu
      50                  55                  60                
 Ile Thr Asp Ala His Ala Ile Leu Thr Asp Ile Ser Lys Arg Ser Ile
  65                  70                  75                  80
 Tyr Asp Lys Tyr Gly Ser Leu Gly Leu Tyr Val Ala Glu Gln Phe Gly
                  85                  90                  95    
 Asp Glu Asn Val Asn Thr Tyr Phe Met Leu Ser Ser Trp Trp Ala Lys
             100                 105                 110        
 Ala Leu Phe Val Ile Val Gly Leu Leu Thr Gly Cys Tyr Phe Cys Cys
         115                 120                 125            
 Cys Leu Cys Cys Cys Cys Asn Cys Cys Cys Gly His Cys Arg Pro Glu
     130                 135                 140                
 Ser Ser Val Pro Glu Glu Asp Phe Tyr Val Ser Pro Glu Asp Leu Glu
 145                 150                 155                 160
 Glu Gln Ile Lys Ser Asp Met Glu Lys Asp Val Asp Phe Pro Val Phe
                 165                 170                 175    
 Leu Gln Pro Thr Asn Ala Asn Glu Lys Thr Gln Leu Ile Lys Glu Gly
             180                 185                 190        
 Ser Arg Ser Tyr Cys Thr Asp Ser
         195                 200



      <210> 538
      <211> 509
      <212> PRT
      <213> Homo sapiens


      <400> 538
 Arg Leu Ala Ala Ala Gly Ala Asp Pro Ala Gly Ser Arg Gly Gly Arg
   1               5                  10                  15    
 Gly Ser Arg Glu Ala Pro Thr Glu Ala Ala Arg Cys Arg Ala Ser Pro
              20                  25                  30        
 Pro Pro Arg Ala Gly Ala Met Arg Gly Ser Pro Gly Asp Ala Glu Arg
          35                  40                  45            
 Arg Gln Arg Trp Gly Arg Leu Phe Glu Glu Leu Asp Ser Asn Lys Asp
      50                  55                  60                
 Gly Arg Val Asp Val His Glu Leu Arg Gln Gly Leu Ala Arg Leu Gly
  65                  70                  75                  80
 Gly Gly Asn Pro Asp Pro Gly Ala Gln Gln Gly Ile Ser Ser Glu Gly
                  85                  90                  95    
 Asp Ala Asp Pro Asp Gly Gly Leu Asp Leu Glu Glu Phe Ser Arg Tyr
             100                 105                 110        
 Leu Gln Glu Arg Glu Gln Arg Leu Leu Leu Met Phe His Ser Leu Asp
         115                 120                 125            
 Arg Asn Gln Asp Gly His Ile Asp Val Ser Glu Ile Gln Gln Ser Phe
     130                 135                 140                
 Arg Ala Leu Gly Ile Ser Ile Ser Leu Glu Gln Ala Glu Lys Ile Leu
 145                 150                 155                 160
 His Ser Met Asp Arg Asp Gly Thr Met Thr Ile Asp Trp Gln Glu Trp
                 165                 170                 175    
 Arg Asp His Phe Leu Leu His Ser Leu Glu Asn Val Glu Asp Val Leu
             180                 185                 190        
 Tyr Phe Trp Lys His Ser Thr Val Leu Asp Ile Gly Glu Cys Leu Thr
         195                 200                 205            
 Val Pro Asp Glu Phe Ser Lys Gln Glu Lys Leu Thr Gly Met Trp Trp
     210                 215                 220                
 Lys Gln Leu Val Ala Gly Ala Val Ala Gly Ala Val Ser Arg Thr Gly
 225                 230                 235                 240
 Thr Ala Pro Leu Asp Arg Leu Lys Val Phe Met Gln Val His Ala Ser
                 245                 250                 255    
 Lys Thr Asn Arg Leu Asn Ile Leu Gly Gly Leu Arg Ser Met Val Leu
             260                 265                 270        
 Glu Gly Gly Ile Arg Ser Leu Trp Arg Gly Asn Gly Ile Asn Val Leu
         275                 280                 285            
 Lys Ile Ala Pro Glu Ser Ala Ile Lys Phe Met Ala Tyr Glu Gln Ile
     290                 295                 300                
 Lys Arg Ala Ile Leu Gly Gln Gln Glu Thr Leu His Val Gln Glu Arg
 305                 310                 315                 320
 Phe Val Ala Gly Ser Leu Ala Gly Ala Thr Ala Gln Thr Ile Ile Tyr
                 325                 330                 335    
 Pro Met Glu Val Leu Lys Thr Arg Leu Thr Leu Arg Arg Thr Gly Gln
             340                 345                 350        
 Tyr Lys Gly Leu Leu Asp Cys Ala Arg Arg Ile Leu Glu Arg Glu Gly
         355                 360                 365            
 Pro Arg Ala Phe Tyr Arg Gly Tyr Leu Pro Asn Val Leu Gly Ile Ile
     370                 375                 380                
 Pro Tyr Ala Gly Ile Asp Leu Ala Val Tyr Glu Thr Leu Lys Asn Trp
 385                 390                 395                 400
 Trp Leu Gln Gln Tyr Ser His Asp Ser Ala Asp Pro Gly Ile Leu Val
                 405                 410                 415    
 Leu Leu Ala Cys Gly Thr Ile Ser Ser Thr Cys Gly Gln Ile Ala Ser
             420                 425                 430        
 Tyr Pro Leu Ala Leu Val Arg Thr Arg Met Gln Ala Gln Ala Ser Ile
         435                 440                 445            
 Glu Gly Gly Pro Gln Leu Ser Met Leu Gly Leu Leu Arg His Ile Leu
     450                 455                 460                
 Ser Gln Glu Gly Met Arg Gly Leu Tyr Arg Gly Ile Ala Pro Asn Phe
 465                 470                 475                 480
 Met Lys Val Ile Pro Ala Val Ser Ile Ser Tyr Val Val Tyr Glu Asn
                 485                 490                 495    
 Met Lys Gln Ala Leu Gly Val Thr Ser Arg Ser Phe Cys
             500                 505                



      <210> 539
      <211> 207
      <212> PRT
      <213> Homo sapiens


      <400> 539
 Arg Arg Arg Cys Phe Gln Gly Phe Leu Lys Lys Lys Lys Ile Ile Gln
   1               5                  10                  15    
 Pro Lys Gly Glu Gly Thr Gly Arg Gly Arg Gly Val Val Pro Phe Ile
              20                  25                  30        
 His Asn Ile Val Asn Ile His Gly Leu Tyr Tyr Met Cys Phe Ser Leu
          35                  40                  45            
 Val Phe Ala Cys Leu Ser Val Arg Leu Ser Val Trp Gly Leu Asp Leu
      50                  55                  60                
 Arg Ser Arg Ala Pro Leu Leu Pro Gln Pro Pro Pro Pro Cys Pro Thr
  65                  70                  75                  80
 Leu Gly Thr Glu Leu Glu Gln Val Trp Pro Pro Asn His Arg Trp Glu
                  85                  90                  95    
 Pro Ala Gly Ser Ala Trp Ala Thr Ala Ser Thr Leu Ala Pro Glu Ser
             100                 105                 110        
 Cys Val Cys Lys Cys Val Cys Val Tyr Ala Cys Leu Ser Met Cys Met
         115                 120                 125            
 Tyr Val His Gly Glu Pro Val Cys Lys Tyr Val Gln Arg Glu Thr Val
     130                 135                 140                
 Thr Val Thr Glu Ala Gly Gly Arg Trp Gly Cys Trp Arg Arg Gly Leu
 145                 150                 155                 160
 Pro Gly Ala Asp Ser Ser Gln Val Asp Pro Pro Gln Val Ser Gly Arg
                 165                 170                 175    
 Cys Asp Arg Val Ala Leu Arg Ala Glu Leu Leu Gly Thr Gln Gly Pro
             180                 185                 190        
 Gln Pro Ala Leu Leu Ala Val His Val Pro Thr Leu Asp Gly Arg
         195                 200                 205        



      <210> 540
      <211> 399
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(393)
      <223> Xaa = any amino acid or nothing 


      <400> 540
 Val Ser Phe Leu Leu Trp Thr Ser Gly Asn Lys Glu Asp Gly Arg Asn
   1               5                  10                  15    
 Gly Pro Ala Val Pro Ser Arg His Thr Gly Gly Ser Arg Thr Trp Arg
              20                  25                  30        
 Met Pro Lys Xaa Gln Glu Gly Glu Asn Pro Cys Pro Leu Pro Lys Arg
          35                  40                  45            
 Asn Leu Gly Asn Ala Xaa Thr Phe Asn Ser Xaa Lys Arg Thr Gly Pro
      50                  55                  60                
 Gly Ser Pro Asp Ser Lys Gly Pro Asp Leu Gly Pro Ile Ser Val Pro
  65                  70                  75                  80
 His Ile Leu Ser Gly Ser Pro Gly Pro Ser Ser Pro Thr Leu Pro Gln
                  85                  90                  95    
 Leu His Asp Leu Leu Ala Ile Pro Val Met Gln Gly Arg Glu Ala Gly
             100                 105                 110        
 Gly Leu Arg Gly His Arg Ala Leu Pro Leu Ala Xaa Glu Glu Ala Gly
         115                 120                 125            
 Arg Ala Leu Gln Leu Pro Leu Ser Gln Pro Pro Pro Cys Arg Pro Ala
     130                 135                 140                
 Ala Pro Phe Phe Asn Gln Gly Pro Gln Gly Cys Cys Pro Trp Arg Gly
 145                 150                 155                 160
 Ser Gly His Ser Pro Gly Pro Gln Leu Gly Gly Xaa Glu Pro Gly Ala
                 165                 170                 175    
 Tyr Ser Gly Trp Gln Gln Thr Ser Arg Met Ser Gly Val Ala Lys Pro
             180                 185                 190        
 Gly Ser Gly Val Arg Pro Ala Thr Gly Ser Pro Thr Arg Val Pro Pro
         195                 200                 205            
 Gly Ala Cys Ser Gln Ser Leu Pro Gly Thr Ala Pro Ser Pro Arg Pro
     210                 215                 220                
 Pro Gly Pro Pro Ala Leu Leu Arg Pro Ala Gly Val Gly Ala Leu Gln
 225                 230                 235                 240
 Gly His Gln Ser Arg Trp Gln Arg Gln Thr Pro Arg Ala Arg Glu Pro
                 245                 250                 255    
 Arg Pro Val Pro Leu Cys Ser Leu Pro Ala Pro Pro Gly Ser Val Gly
             260                 265                 270        
 Pro Gly Pro Arg Asp Ser Gln Arg Arg Ile Ala Gly Cys Pro Xaa Gly
         275                 280                 285            
 Gln Thr Ser Ile Phe Gly Gln Cys His Trp Gly Ser Val Gly Ser Leu
     290                 295                 300                
 Gly Pro Pro Arg Cys Ala Gly Ser Pro Cys Gly Pro Leu Gly Ser Arg
 305                 310                 315                 320
 Xaa Val His Ser Gly Leu His Ser Ser Arg Ser Ala Ser Trp Leu Pro
                 325                 330                 335    
 Arg Glu Gln Gln Gly Ser Pro Gly Gly Gly Gln Gly Pro Leu Val Trp
             340                 345                 350        
 Pro His Ser Ser Ala Leu Arg Pro Pro Gly Val Pro Gly Asn Leu Pro
         355                 360                 365            
 Pro Pro Ile Ala Pro Lys Pro Lys Arg Ala Ile Pro Ala Arg Asp Pro
     370                 375                 380                
 Ala Pro Pro Pro Gly Leu Gln His Glu
 385                 390            



      <210> 541
      <211> 146
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(145)
      <223> Xaa = any amino acid or nothing 


      <400> 541
 Met Leu Ala Ile Phe Lys Tyr Leu Ile Asn Asn Arg Leu Ile Thr Thr
   1               5                  10                  15    
 Xaa Gln Trp Thr Glu Lys Leu Thr Ser Xaa Gln Met Ile Thr Ile His
              20                  25                  30        
 Asn Thr Lys Gly Leu Thr Xaa Ser Leu Ile Leu Leu Ser Leu Ile Ile
          35                  40                  45            
 Phe Ile Ala Thr Thr Asn Leu Leu Gly Leu Leu Pro Tyr Ser Phe Thr
      50                  55                  60                
 Pro Thr Thr Gln Leu Ser Ile Asn Leu Ser Met Ala Ile Pro Leu Xaa
  65                  70                  75                  80
 Thr Val Ala Glu Phe Ile Gly Phe Arg Ser Lys Ile Lys Asn Ala Leu
                  85                  90                  95    
 Ser His Phe Leu Pro Gln Gly Thr Pro Thr Pro Leu Ile Pro Ile Leu
             100                 105                 110        
 Val Ile Ile Glu Thr Ile Ser Leu Leu Ile Gln Pro Ile Leu Leu Asp
         115                 120                 125            
 Val Leu Leu Thr Ala Asn Ile Thr Ala Gly His Leu Leu Ile His Leu
     130                 135                 140                
 Asn
 145



      <210> 542
      <211> 189
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(187)
      <223> Xaa = any amino acid or nothing 


      <400> 542
 Leu Asn Ile Asn Lys Lys Tyr Asn Tyr Ile Lys Arg Xaa Asp Tyr Tyr
   1               5                  10                  15    
 Lys Ile Ile Ile Asn Lys Lys Met Asn Ile Ile Xaa Ile Asn Lys Xaa
              20                  25                  30        
 Tyr Asn Lys Glu Xaa Tyr Lys Xaa Asn Met Lys Lys Ile Ile Lys Tyr
          35                  40                  45            
 Xaa Ile Tyr Tyr Ser Gln Val Ser Thr Pro Thr Ile Val Lys Val Ser
      50                  55                  60                
 Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala
  65                  70                  75                  80
 Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Tyr Val Val Leu Asn Gln
                  85                  90                  95    
 Leu Xaa Val Leu His Glu Lys Thr Pro Val Asn Asp Arg Val Thr Lys
             100                 105                 110        
 Cys Xaa Lys Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Thr Leu
         115                 120                 125            
 Glu Val Asp Lys Thr Tyr Val Thr Lys Lys Phe Asn Ala Glu Thr Phe
     130                 135                 140                
 Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile
 145                 150                 155                 160
 Lys Lys Gln Thr Ala Leu Asp Glu Leu Val Lys His Lys Pro Lys Ala
                 165                 170                 175    
 Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp
             180                 185        



      <210> 543
      <211> 65
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(64)
      <223> Xaa = any amino acid or nothing 


      <400> 543
 Ser Ser Ser Ser Ser Ser Pro Ser Thr Pro Gly Pro Pro Ser Pro Phe
   1               5                  10                  15    
 Leu Arg Gln Pro Pro Phe Gly Leu Asn Pro Phe Leu Pro Ala Gly Asp
              20                  25                  30        
 Xaa Gly Thr Gln Arg Gly Gly Ser Gly Arg Gly Gly Arg Gly Arg Gly
          35                  40                  45            
 Arg Asp Gly Ser Thr Asn Glu Gly Arg Gly Glu Arg Arg Gly Gln Gly
      50                  55                  60                





      <210> 544
      <211> 131
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(130)
      <223> Xaa = any amino acid or nothing 


      <400> 544
 Ala Lys Arg Lys Ser Val Pro Glu Glu Ile Trp Lys Ser Arg Gly Gln
   1               5                  10                  15    
 Phe Lys Asn Gln Gln Leu Asn Lys Glu Asn Asn Leu Gly Gln Glu Ile
              20                  25                  30        
 Ala Thr Cys Thr Lys Ile Pro Ser Arg Lys Arg Asp Ile Glu Phe Asn
          35                  40                  45            
 Glu Phe Val Lys Asn Phe Thr Val Arg Ser Ile Leu Val Ala Glu Gln
      50                  55                  60                
 Ile Asp Pro Met Glu Glu Asn Cys His Lys Tyr Gly Thr Cys Xaa Lys
  65                  70                  75                  80
 Met Leu Lys Gln Asn Ser Asp Leu Ile Ile Gln Glu Ser Met Met Glu
                  85                  90                  95    
 Lys Lys Lys Pro Cys Lys Tyr Ser Glu Cys Gly Arg Thr Phe Arg Gly
             100                 105                 110        
 His Ile Thr Leu Val Gln His Gln Ile Thr His Cys Gly Glu Arg Pro
         115                 120                 125            
 Cys Ile
     130



      <210> 545
      <211> 97
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(96)
      <223> Xaa = any amino acid or nothing 


      <400> 545
 Asn Asn Lys Asn Lys Ile Ala Ser Lys Arg Lys Lys Asn Ser Pro Glu
   1               5                  10                  15    
 Pro Gly Gly Leu Thr Thr Glu Leu Tyr Gln Thr Ser Lys Glu Glu Leu
              20                  25                  30        
 Glu Pro Ile Leu Leu Asn Leu Phe Gln Lys Ile Glu Lys Glu Glu Ile
          35                  40                  45            
 Leu Ser Asn Ser Phe Arg Glu Thr Ser Ile Ala Leu Ile Pro Lys Pro
      50                  55                  60                
 Gly Lys Asp Ile Thr Lys Glu Val Asn His Arg Pro Ile Ser Leu Met
  65                  70                  75                  80
 Asn Arg Asp Ala Lys Val Leu Asn Lys Met Leu Ser Asn Xaa Ile Gln
                  85                  90                  95    





      <210> 546
      <211> 141
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(139)
      <223> Xaa = any amino acid or nothing 


      <400> 546
 Gly Lys Pro Pro Phe Tyr Phe Gly Gly Pro Gly Phe Phe Pro Pro Pro
   1               5                  10                  15    
 Val Tyr Phe Lys Pro Pro Pro Pro Lys Asn Phe Phe Gly Pro Pro Lys
              20                  25                  30        
 Lys Lys Lys Phe Pro Pro Pro Pro Gly Val Tyr Phe Phe Phe Phe Leu
          35                  40                  45            
 Arg Pro Pro Pro Pro Leu Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
      50                  55                  60                
 Phe Phe Phe Xaa Glu Gly Gly Gly Glu Lys Pro Ser Pro Pro Ile Lys
  65                  70                  75                  80
 Lys Gly Phe Phe Lys Pro Lys Lys Phe Phe Ser Pro Pro Pro Gly Gly
                  85                  90                  95    
 Lys Lys Lys Pro Pro Phe Leu Lys Lys Lys Lys Lys Lys Lys Asp Val
             100                 105                 110        
 Pro Gln Ser Ser Asn Leu Glu Ser Ser Leu Ser Phe Pro Ile His Lys
         115                 120                 125            
 Thr Gly Thr Ile Ile Pro Ala Ser Leu Asn Val
     130                 135                



      <210> 547
      <211> 130
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(129)
      <223> Xaa = any amino acid or nothing 


      <400> 547
 His Thr Leu Leu Leu Gln Cys Leu Ser Ala Val Ala Phe Ser Gln Pro
   1               5                  10                  15    
 Cys Pro His Pro Ser Arg Leu Cys Asn Pro Cys Cys Ala Ser Gly Pro
              20                  25                  30        
 Pro Cys Ser Ser Xaa Ala Cys Cys Pro Arg Phe Cys Gln Ser Cys Pro
          35                  40                  45            
 Val Cys Xaa Pro Gln Asn Leu Leu Ser Ser Cys Pro Ser Pro Asp Leu
      50                  55                  60                
 Ala Leu Thr Ser Pro Ser Ala Gly Arg Pro Arg Cys Trp Trp Asn Cys
  65                  70                  75                  80
 Cys Gln Leu Thr Pro Cys Leu Ser Leu Gln Thr Gln Glu Trp Thr Gly
                  85                  90                  95    
 Ala His Leu Gln Leu Arg Arg Trp Gly Thr Gln Ala Gly Pro Glu Glu
             100                 105                 110        
 Pro Val His Gln Arg Thr Val Gly Ser Thr Ser His Ser Cys Ser Tyr
         115                 120                 125            
 Ala
    



      <210> 548
      <211> 139
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(137)
      <223> Xaa = any amino acid or nothing 


      <400> 548
 Arg Trp Ser Ala Arg Ser Arg Ile Thr Gly Glu Glu Gly Ser Glu Ser
   1               5                  10                  15    
 Ala Val Gln Glu Arg Xaa Leu Thr Tyr His Thr His Gly Gly Ile Ala
              20                  25                  30        
 Asn Arg Asp Arg Thr His Cys Pro Val Ser Leu Val Asn Val Ser Ser
          35                  40                  45            
 Met Ser Ala Gly Asp Val Ile Thr Ala Gly Lys Met Gln Gly Lys Val
      50                  55                  60                
 Val Leu Ala Glu Pro Thr Ala Ala Leu Cys His Gly Asn Gly Leu His
  65                  70                  75                  80
 Tyr Tyr Arg Gln Asp Trp Ser His Ala Ala Ala Tyr Val Thr Val Pro
                  85                  90                  95    
 Pro Val Arg Val Asp Thr Asn Thr Ser Thr Tyr Leu Met Ser Leu Leu
             100                 105                 110        
 Ala Asn Asp Thr Leu Asn Ile Val Ala Ser Asp Arg Arg Pro Phe Thr
         115                 120                 125            
 Thr Lys Gln Lys Ala Met Gly Asn Val
     130                 135        



      <210> 549
      <211> 118
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(117)
      <223> Xaa = any amino acid or nothing 


      <400> 549
 Gly Cys Leu Val Ser Leu Gly Val Ser His Ala Trp Gln Arg Val Gly
   1               5                  10                  15    
 Thr Trp Glu Ile Phe Val Gly Xaa Met Asn Ala Gly Xaa Met Ser Ala
              20                  25                  30        
 Xaa Thr Arg Gly Thr Glu Ile Ser Arg Ile Gly Gln Trp Met Gly Gly
          35                  40                  45            
 Glu Gly Met Ser Gly Leu Thr Ser Trp Phe Leu Leu Gly Glu Met Asn
      50                  55                  60                
 Pro Xaa Gly Leu Arg Glu Leu Asn Leu Leu Leu Thr Leu Ser Ile Thr
  65                  70                  75                  80
 Met Asn Gly Glu Thr Ile Ala Cys Ala Glu Gly Cys Gln Ala Ile Cys
                  85                  90                  95    
 Asp Thr Gly Thr Ser Leu Leu Thr Gly Pro Thr Ser Pro Ile Ala Gln
             100                 105                 110        
 His Gln Ser Asp Ile
         115        



      <210> 550
      <211> 147
      <212> PRT
      <213> Homo sapiens


      <400> 550
 Leu Leu Asp Asn Cys Gln Met Thr Val Leu Gly Ala Pro Thr Cys Ile
   1               5                  10                  15    
 His Gly Asn Thr Val Ser Val Ile Cys Thr Gly Ser Leu Thr Gln Pro
              20                  25                  30        
 Leu Phe Pro Cys Leu Ala Asn Val Ser Asp Pro Tyr Leu Ser Ala Val
          35                  40                  45            
 Pro Glu Gly Ser Ala Leu Ile Cys Leu Glu Asp Lys Arg Leu Arg Leu
      50                  55                  60                
 Val Asp Gly Asp Ser Arg Cys Ala Gly Arg Val Glu Ile Tyr His Asp
  65                  70                  75                  80
 Gly Phe Trp Gly Thr Ile Cys Asp Asp Gly Trp Asp Leu Ser Asp Ala
                  85                  90                  95    
 His Val Val Cys Gln Lys Leu Ser Cys Gly Val Ala Phe Asn Ala Thr
             100                 105                 110        
 Val Ser Ala His Phe Gly Val Gly Ala Gly Pro Ile Trp Leu Asp Asp
         115                 120                 125            
 Leu Asn Cys Thr Gly Met Glu Ser His Leu Arg Gln Cys Pro Phe
     130                 135                 140            



      <210> 551
      <211> 80
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(80)
      <223> Xaa = any amino acid or nothing 


      <400> 551
 Phe Phe Phe Phe Phe Phe Xaa Xaa Xaa Gly Val Xaa Gly Leu Asn Phe
   1               5                  10                  15    
 Phe Phe Phe Xaa Phe Phe Xaa Xaa Phe Phe Phe Phe Phe Phe Phe Xaa
              20                  25                  30        
 Phe Xaa Xaa Xaa Xaa Xaa Phe Phe Phe Phe Phe Xaa Gly Xaa Xaa Xaa
          35                  40                  45            
 Xaa Phe Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Phe Phe Phe Phe Phe Phe
      50                  55                  60                
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Xaa Cys Tyr
  65                  70                  75                  80





      <210> 552
      <211> 28
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(28)
      <223> Xaa = any amino acid or nothing 


      <400> 552
 Glu Val Met His Phe Cys Leu Phe Val Phe Xaa Asp Arg Val Leu Leu
   1               5                  10                  15    
 Cys His Pro Gly Trp Ser Ala Val Ala Gln Ser Gln
              20                  25            



      <210> 553
      <211> 87
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(87)
      <223> Xaa = any amino acid or nothing 


      <400> 553
 Thr Ala Pro Lys Lys Lys Lys Gly Gly Ala Pro Leu Gly Gly Pro Pro
   1               5                  10                  15    
 Arg Gly Pro Ile Leu Pro Arg Ile Pro Glu Asn Arg Arg Pro Pro Xaa
              20                  25                  30        
 Xaa Gly Ala Leu Leu Lys Pro Ser Pro Gly Pro Arg Phe Asn Thr Ala
          35                  40                  45            
 Trp Pro Gly Lys Pro Ala Pro Arg Glu Ser Leu Lys Arg Ala Pro Ser
      50                  55                  60                
 Leu Gly Gly Gly Pro Lys Arg Pro Asn Pro Pro Pro Glu Val Lys Ala
  65                  70                  75                  80
 Ser Gly Ala Asp Lys Lys Leu
                  85        



      <210> 554
      <211> 121
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(121)
      <223> Xaa = any amino acid or nothing 


      <400> 554
 Tyr His Ile Val Gln Pro Ser Pro Xaa Pro Leu Ala Gly Ala Leu Ser
   1               5                  10                  15    
 Ala Leu Leu Met Thr Ser Gly Leu Ala Met Arg Ser His Phe His Ser
              20                  25                  30        
 Ile Thr Leu Leu Ile Leu Gly Leu Leu Ser Ser Thr Leu Thr Ile Tyr
          35                  40                  45            
 Gln Xaa Trp Arg Asp Val Thr Arg Glu Ser Thr Tyr Gln Gly His His
      50                  55                  60                
 Thr Pro Pro Val Arg Lys Gly Leu Arg Tyr Gly Ile Ile Leu Phe Ile
  65                  70                  75                  80
 Thr Ser Glu Val Ile Phe Phe Ala Gly Leu Phe Xaa Ala Phe Tyr His
                  85                  90                  95    
 Ser Ser Leu Ala Pro Thr Pro Gln Leu Gly Gly His Trp Pro Pro Thr
             100                 105                 110        
 Gly Ile Thr Pro Leu Asn Thr Leu Glu
         115                 120    



      <210> 555
      <211> 63
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(63)
      <223> Xaa = any amino acid or nothing 


      <400> 555
 Leu Met Asn Ser Asn Ser Ile Pro Pro Ile Pro Leu Arg Pro Thr His
   1               5                  10                  15    
 Thr Pro Pro Met Lys Lys Leu Xaa Ile Arg Thr Ala Tyr Pro Arg Phe
              20                  25                  30        
 Arg Tyr Asp Gln Leu Ile His Leu Leu Xaa Lys Asn Phe Leu Pro Leu
          35                  40                  45            
 Thr Leu Ala Leu Leu Ile Xaa His Val Lys Lys Lys Lys Lys Lys
      50                  55                  60            



      <210> 556
      <211> 95
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(95)
      <223> Xaa = any amino acid or nothing 


      <400> 556
 Pro Ala Cys Gly Gly Phe Ser Pro Pro Pro Pro Pro Lys Phe Phe Phe
   1               5                  10                  15    
 Phe Pro Pro Pro Leu Phe Phe Phe Gly Gly Gly Gly Pro Pro Phe Pro
              20                  25                  30        
 Pro Pro Pro Lys Gly Phe Phe Phe Pro Asn Pro Pro Arg Gly Phe Phe
          35                  40                  45            
 Phe Pro Pro Pro Xaa Lys Lys Lys Phe Phe Phe Pro Pro Pro Pro Phe
      50                  55                  60                
 Phe Cys Pro Pro Pro Val Phe Phe Phe Cys Pro Pro Pro Leu Phe Phe
  65                  70                  75                  80
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
                  85                  90                  95



      <210> 557
      <211> 124
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(124)
      <223> Xaa = any amino acid or nothing 


      <400> 557
 Phe Val Ala Ala Glu Val Arg Asp Gly Gly Gly Gly Ala Gly Thr Arg
   1               5                  10                  15    
 Pro Pro Ser Gly Arg Met Lys Arg Arg Asn Ala Asp Cys Ser Lys Leu
              20                  25                  30        
 Arg Arg Pro Leu Lys Arg Asn Arg Ile Thr Glu Gly Ile Tyr Gly Ser
          35                  40                  45            
 Thr Phe Leu Tyr Leu Lys Phe Leu Val Val Trp Ala Leu Val Leu Leu
      50                  55                  60                
 Ala Asp Phe Val Leu Glu Phe Arg Phe Glu Tyr Leu Trp Pro Phe Trp
  65                  70                  75                  80
 Leu Phe Ile Arg Ser Val Tyr Asp Ser Phe Arg Tyr Gln Gly Leu Val
                  85                  90                  95    
 Cys Leu Val Ile His Val Phe His Val Trp Gly Pro Phe Ser Cys Leu
             100                 105                 110        
 Glu Xaa Met Leu Leu Ala Ile Leu Arg Xaa Leu Cys
         115                 120                



      <210> 558
      <211> 140
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(140)
      <223> Xaa = any amino acid or nothing 


      <400> 558
 Val Leu Asn His Ser Tyr Met Ile Pro Gly Arg Arg Asn Val Thr Arg
   1               5                  10                  15    
 Cys Ile Ser Arg Gln Leu Glu Val Gln Pro His Ala Leu Glu Leu Pro
              20                  25                  30        
 Asp Lys Cys Ser Leu Ala Phe Val Val Arg Ile Lys Arg Ile Asp Gly
          35                  40                  45            
 Gly Ser Leu Leu Val Gln Arg Thr Ile Ala Arg Leu Cys Leu Lys Lys
      50                  55                  60                
 Ile Phe Ser Gly Val Phe Leu Lys Met Leu Arg Ile Val Glu Pro Tyr
  65                  70                  75                  80
 Val Thr Xaa Gly Phe Pro Asn Leu Lys Ser Val Trp Glu Phe Ile Leu
                  85                  90                  95    
 Lys His Gly Gln Ala Lys Val Lys Asn Lys Thr Ile Gly Gln Thr Gln
             100                 105                 110        
 Trp Leu Thr Pro Val Ile Pro Ala Leu Trp Glu Ala Lys Asp Gly Trp
         115                 120                 125            
 Ile Met Arg Ser Gly Asp Arg Asp His Pro Gly Gln
     130                 135                 140



      <210> 559
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 559
 Glu Val Arg Ser His Val Lys Val Leu Gly Glu Met Leu Val Met Tyr
   1               5                  10                  15    
 Arg Arg Pro Gly Gln Ala Pro Pro Asp Gln Glu Ala Leu Gln Val Val
              20                  25                  30        
 Tyr Glu Arg Cys Glu Lys Leu Arg Pro Thr Leu Phe Arg Leu Ala Ser
          35                  40                  45            
 Asp Thr Thr Asp Asp Asp Asp Ala Leu Ser Glu Ile Leu Gln Ala Asn
      50                  55                  60                
 Asp Leu Leu Thr Gln Gly Val Leu Leu Tyr Lys Gln Val Met Glu Gly
  65                  70                  75                  80
 Arg Val Thr Phe Gly Asn Arg Val Thr Ser Ser Leu Gly Asp Ile Pro
                  85                  90                  95    
 Val Ser Arg Val Phe Gln Asn Pro Ala Gly Cys Met Lys Thr Cys Pro
             100                 105                 110        
 Leu Ile Asp Leu Glu Val Asp Asn Gly Pro Ala Gln Met Gly Thr Val
         115                 120                 125            
 Val Pro Ser Leu Leu His Gln Asp Leu Ala Ala Leu Gly Asn Ser Asp
     130                 135                 140                
 Ala Pro Val Thr Gly Met Val
 145                 150    



      <210> 560
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 560
 Arg Arg Arg Ala Asp Gly Cys Ile Tyr Gly Val Ser Arg Arg Ala Arg
   1               5                  10                  15    
 Val Val Ala Tyr Arg Arg Asp Glu Met Trp Ser Glu Gly Arg Tyr Glu
              20                  25                  30        
 Tyr Glu Arg Ile Pro Arg Glu Arg Ala Pro Pro Arg Ser His Pro Ser
          35                  40                  45            
 Asp Glu Ser Gly Tyr Arg Trp Thr Arg Asp Asp His Ser Ala Ser Arg
      50                  55                  60                
 Gln Pro Glu Tyr Arg Asp Met Arg Asp Gly Phe Arg Arg Lys Ser Phe
  65                  70                  75                  80
 Tyr Ser Ser His Tyr Ala Arg Glu Arg Ser Pro Tyr Lys Arg Asp Asn
                  85                  90                  95    
 Thr Phe Phe Arg Glu Ser Pro Val Gly Arg Lys Asp Ser Pro His Ser
             100                 105                 110        
 Arg Ser Gly Ser Ser Val Ser Ser Arg Ser Tyr Ser Pro Glu Arg Ser
         115                 120                 125            
 Lys Ser Tyr Ser Phe His Gln Ser Gln His Arg Lys Ser Val Arg Pro
     130                 135                 140                
 Gly Ala Ser Tyr Lys Arg Gln Asn Glu Gly Asn Pro Glu Arg Asp Lys
 145                 150                 155                 160
 Glu Arg Pro Val Gln Ser Leu Lys Thr Ser Arg Asp Thr Ser Pro Ser
                 165                 170                 175    
 Ser Gly Ser Ala Val Ser Ser Ser Lys Val Leu Asp Lys Pro Ser Arg
             180                 185                 190        
 Leu Thr Glu Lys Glu Leu Ala Glu Ala Ala Ser Lys Trp Ala Ala Glu
         195                 200                 205            
 Lys Leu Glu Lys Ser Asp Glu Ser Asn Leu Pro Glu Ile Ser Glu Tyr
     210                 215                 220                
 Glu Ala Gly Ser Thr Ala Pro Leu Phe Thr Asp Gln Pro Glu Glu Pro
 225                 230                 235                 240
 Glu Ser Asn Thr Thr His Gly Ile Glu Leu Phe Glu Asp Ser Gln Leu
                 245                 250                 255    
 Thr Thr Arg Ser Lys Ala Ile Ala Ser Lys Thr Lys Glu Ile Glu Gln
             260                 265                 270        
 Val Tyr Arg Gln Asp Cys Glu Thr Phe Gly Met Val Val Lys Met Leu
         275                 280                 285            
 Ile Glu Lys Asp Pro Ser Leu Glu Lys Ser Ile Gln Phe Ala Leu Arg
     290                 295                 300                
 Gln Asn Leu His Glu Ile Gly Glu Arg Cys Val Glu Glu Leu Lys His
 305                 310                 315                 320
 Phe Ile Ala Glu Tyr Asp Thr Ser Thr Gln Asp Phe Gly Glu Pro Phe
                 325                 330                 335    





      <210> 561
      <211> 482
      <212> PRT
      <213> Homo sapiens


      <400> 561
 Leu Leu Ile Arg Glu Val Phe Ile Gln Val Leu Ile Lys Leu Arg Val
   1               5                  10                  15    
 Cys Phe Val Gln Cys Phe Ser Glu Ala Asp Arg Asp Ile Met Thr Leu
              20                  25                  30        
 Ala Asn His Trp Asn Cys Pro Val Leu Ser Ser Asp Ser Asp Phe Cys
          35                  40                  45            
 Ile Phe Asp Leu Lys Thr Gly Phe Cys Pro Leu Asn Ser Phe Gln Trp
      50                  55                  60                
 Arg Asn Met Asn Thr Ile Lys Gly Thr Gln Asn Tyr Ile Pro Ala Lys
  65                  70                  75                  80
 Cys Phe Ser Leu Asp Ala Phe Cys His His Phe Ser Asn Met Asn Lys
                  85                  90                  95    
 Ala Leu Leu Pro Leu Phe Ala Gly Leu Cys Gly Asn Asp His Val Asn
             100                 105                 110        
 Leu Pro Ile Met Glu Thr Phe Leu Ser Lys Ala Arg Leu Pro Leu Gly
         115                 120                 125            
 Ala Thr Ser Ser Lys Gly Arg Arg His His Arg Ile Leu Gly Leu Leu
     130                 135                 140                
 Asn Trp Leu Ser His Phe Ala Asn Pro Thr Glu Ala Leu Asp Asn Val
 145                 150                 155                 160
 Leu Lys Tyr Leu Pro Lys Lys Asp Arg Glu Asn Val Lys Glu Leu Leu
                 165                 170                 175    
 Cys Cys Ser Met Glu Glu Tyr Gln Gln Ser Gln Val Lys Leu Gln Asp
             180                 185                 190        
 Phe Phe Gln Cys Gly Thr Tyr Val Cys Pro Asp Ala Leu Asn Leu Gly
         195                 200                 205            
 Leu Pro Glu Trp Val Leu Val Ala Leu Ala Lys Gly Gln Leu Ser Pro
     210                 215                 220                
 Phe Ile Ser Asp Ala Leu Val Leu Arg Arg Thr Ile Leu Pro Thr Gln
 225                 230                 235                 240
 Val Glu Asn Met Gln Gln Pro Asn Ala His Arg Ile Ser Gln Pro Ile
                 245                 250                 255    
 Arg Gln Ile Ile Tyr Gly Leu Leu Leu Asn Ala Ser Pro His Leu Asp
             260                 265                 270        
 Lys Thr Ser Trp Asn Ala Leu Pro Pro Gln Pro Leu Ala Phe Ser Glu
         275                 280                 285            
 Val Glu Arg Ile Asn Lys Asn Ile Arg Thr Ser Ile Ile Asp Ala Val
     290                 295                 300                
 Glu Leu Ala Lys Asp His Ser Asp Leu Ser Arg Leu Thr Glu Leu Ser
 305                 310                 315                 320
 Leu Arg Arg Arg Gln Met Leu Leu Leu Glu Thr Leu Lys Val Lys Gln
                 325                 330                 335    
 Thr Ile Leu Glu Pro Ile Pro Thr Ser Leu Lys Leu Pro Ile Ala Val
             340                 345                 350        
 Ser Cys Tyr Trp Leu Gln His Thr Glu Thr Lys Ala Lys Leu His His
         355                 360                 365            
 Leu Gln Ser Leu Leu Leu Thr Met Leu Val Gly Pro Leu Ile Ala Ile
     370                 375                 380                
 Ile Asn Ser Pro Gly Lys Glu Glu Leu Gln Glu Asp Gly Ala Lys Met
 385                 390                 395                 400
 Leu Tyr Ala Glu Phe Gln Arg Val Lys Ala Gln Thr Arg Leu Gly Thr
                 405                 410                 415    
 Arg Leu Asp Leu Asp Thr Ala His Ile Phe Cys Gln Trp Gln Ser Cys
             420                 425                 430        
 Leu Gln Met Gly Asp Val Ser Gln Pro Ala Ala Val His Ser Ser Pro
         435                 440                 445            
 Arg Ala Arg Pro Asn Ser Thr Val Gln Trp Lys Pro Gly Ala Arg Thr
     450                 455                 460                
 Met Pro Ala Thr Ala Ser Ile Asp Leu Cys Arg Lys Ser Pro Glu His
 465                 470                 475                 480
 Met Ser
        



      <210> 562
      <211> 59
      <212> PRT
      <213> Homo sapiens


      <400> 562
 Thr Arg His Phe Tyr Leu Lys Lys Asn Asn Phe Pro Pro Thr Gln Lys
   1               5                  10                  15    
 Ser Cys Leu Pro Leu Phe Ser Leu Ser Ser Leu Cys Val Cys Val Cys
              20                  25                  30        
 Val Cys Val Cys Val Cys Val Cys Val Cys Val Tyr Ser Ser Ala Phe
          35                  40                  45            
 Lys Lys Thr Arg Arg Met His Arg Trp Ile Arg
      50                  55                



      <210> 563
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 563
 Gly Leu Val Asn Met Ala Leu Tyr Val Ser Pro Ile Val Ser Gly Glu
   1               5                  10                  15    
 Val Ile Arg Ser Arg Gly Gly Ser Thr Ser Glu Phe Thr Pro Gly Tyr
              20                  25                  30        
 Val Lys Pro Lys His Glu Val Asn Pro Gln Met Thr Leu Arg Arg Leu
          35                  40                  45            
 Pro Asp Glu Asp Pro Gln Asn Leu Ala Asp Pro Ala Tyr Arg Arg Arg
      50                  55                  60                
 Arg Ile Ile Met Gln Asn Met Arg Asp Glu Glu Leu Ala Ile Ala Gln
  65                  70                  75                  80
 Val Glu Glu Met Gln Ala Val Ser Ala Val Leu Lys Gly Lys Tyr Thr
                  85                  90                  95    
 Met Thr Gly
            



      <210> 564
      <211> 80
      <212> PRT
      <213> Homo sapiens


      <400> 564
 Ser Phe Val Val Glu Glu Leu Ser Trp Ala Leu Gln Met Leu Gly Arg
   1               5                  10                  15    
 Ile Pro Gly Leu Phe Ala Gln Ile Gln Asn Leu Gly Lys Glu Lys Ile
              20                  25                  30        
 Phe Trp Lys Glu Phe Ser Ile Leu Asp Ala Asn Lys Asn Thr Asp Val
          35                  40                  45            
 Ser Trp Lys Glu Ile Lys Ile Ala Thr Leu Thr Gly Val Trp Lys Lys
      50                  55                  60                
 Leu Ile Leu Thr Phe Glu Thr Val Ser Tyr Lys Ser Gln Asn Gln His
  65                  70                  75                  80





      <210> 565
      <211> 112
      <212> PRT
      <213> Homo sapiens


      <400> 565
 Tyr Asp Val Ile Val Gly Gly Glu Leu Phe Ser Asp Tyr Ser Asp Arg
   1               5                  10                  15    
 Pro Arg Lys Phe Val Ala Leu Asn Pro Lys Leu Lys Ser Thr Gly Ala
              20                  25                  30        
 Gly Arg Tyr Gln Phe Leu Ser Arg Trp Trp Asp Ala Tyr Arg Lys Gln
          35                  40                  45            
 Leu Gly Leu Lys Asp Phe Ser Pro Lys Ser Gln Ala Ala Val Ala Leu
      50                  55                  60                
 Gln Gln Ile Lys Glu Arg Gly Ala Leu Pro Met Ile Asp Arg Gly Asp
  65                  70                  75                  80
 Ile Arg Gln Ala Ile Asp Arg Cys Ser Asn Met Trp Ala Ser Leu Pro
                  85                  90                  95    
 Gly Ala Gly Tyr Gly Gln Phe Glu His Lys Ala Asp Ser Leu Ile Ala
             100                 105                 110        





      <210> 566
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 566
 Gln Glu Glu Trp Ser Leu Leu Ser Glu Ala Gln Arg Cys Leu Tyr His
   1               5                  10                  15    
 Asp Val Met Leu Glu Asn Leu Thr Leu Ile Ser Ser Leu Gly Cys Trp
              20                  25                  30        
 Tyr Gly Ala Lys Asp Glu Thr Pro Ser Lys Gln Thr Leu Ser Ile Gln
          35                  40                  45            
 Gln Glu Ser Pro Leu Arg Thr His Trp Thr Gly Gly Asn Asp Val Thr
      50                  55                  60                
 Leu Lys Leu Arg Leu Glu Tyr Thr Gly Met Val Ile Pro His Cys Gly
  65                  70                  75                  80
 Leu Lys Leu Leu Gly Leu Lys
                  85        



      <210> 567
      <211> 56
      <212> PRT
      <213> Homo sapiens


      <400> 567
 Thr Pro Gly Trp Thr Gln Leu Asp Ser Ser Gln Val Asn Leu Tyr Arg
   1               5                  10                  15    
 Asp Glu Lys Gln Glu Asn His Ser Ser Leu Val Ser Leu Gly Lys Thr
              20                  25                  30        
 Glu Thr Leu Ile Cys Leu Lys Ile Ser Trp His Ser Leu Arg Ile Arg
          35                  40                  45            
 Thr Tyr Trp Ala Val Arg Ser Cys
      50                  55    



      <210> 568
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 568
 Thr Gln Gln Gln Ala Ala Arg Ser Ser Glu Ala His Ser Trp Gln Ser
   1               5                  10                  15    
 Ser Ser Thr Gln Ser Leu Leu Glu Lys Phe Phe Leu Trp Arg Tyr Ser
              20                  25                  30        
 Arg Gly Leu Arg Ile Ser Leu Trp Phe Glu Thr Glu Ser His Cys Val
          35                  40                  45            
 Pro Gln Val Gly Val Arg Trp Cys Asp Leu Gly Ser Leu Lys Pro Leu
      50                  55                  60                
 Pro Pro Gly Phe Arg Arg Phe Ser
  65                  70        



      <210> 569
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 569
 Arg Asp Lys His Ile Asn Asn Leu Lys Lys Lys Cys Gln Lys Glu Ser
   1               5                  10                  15    
 Glu Gln Asn Arg Glu Lys Gln Gln Arg Ile Glu Thr Leu Glu Arg Tyr
              20                  25                  30        
 Leu Ala Asp Leu Pro Thr Leu Glu Asp His Gln Lys Gln Ser Gln Gln
          35                  40                  45            
 Leu Lys Asp Ser Glu Leu Lys Ser Thr Glu Leu Gln Glu Lys Val Thr
      50                  55                  60                
 Glu Leu Glu Ser Leu Leu Glu Glu Thr Gln Ala Ile Cys Arg Glu Lys
  65                  70                  75                  80
 Glu Ile Gln Leu Glu Ser Leu Arg Gln Arg Glu Thr Glu Phe Ser Ser
                  85                  90                  95    
 Ala Gly His Ser Leu Gln Asp Lys Gln Ser Val Glu Glu Thr Ser Gly
             100                 105                 110        
 Glu Gly Pro Glu Val Glu Met Glu Ser Trp Gln Lys Arg Tyr Asp Ser
         115                 120                 125            
 Leu Gln Lys Ile Val Glu Lys Gln Gln Gln Lys Met Asp Gln Leu Arg
     130                 135                 140                
 Ser Gln Val Gln Ser Leu Glu Gln Glu Val Ala Gln Glu Glu Gly Thr
 145                 150                 155                 160
 Ser Gln Ala Leu Arg Glu Glu Ala Gln Arg Arg Asp Ser Ala Leu Gln
                 165                 170                 175    
 Gln Leu Arg Thr Ala Val Lys Glu Leu Ser Val Gln Asn Gln Asp Leu
             180                 185                 190        
 Ile Glu Lys Asn Leu Thr Leu Gln Glu His Leu Arg Gln Ala Gln Pro
         195                 200                 205            
 Gly Ser Pro Pro Ser Pro Asp Thr Ala Gln Leu Ala Leu Glu Leu His
     210                 215                 220                
 Gln Glu Leu Ala Ser Cys Leu Gln Asp Leu Gln Ala Val Cys Ser Ile
 225                 230                 235                 240
 Val Thr Gln Arg Ala Gln Gly His Asp Pro Asn Leu Ser Leu
                 245                 250                



      <210> 570
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 570
 Lys Val Phe Cys Gln Met Asn Ser Leu Leu Asp Ala Arg Ser Leu Ser
   1               5                  10                  15    
 Leu Thr Ser Met Leu Phe Val Cys Glu Val Cys Val Lys Met Cys Asp
              20                  25                  30        
 Pro Ala Lys Gly Ala Ala Gly Gln Arg Thr Ile Ala Ala Leu Leu Pro
          35                  40                  45            
 Cys Leu Leu Asp Lys Gly Met Met Ser Thr Val Thr Glu Val Arg Ala
      50                  55                  60                
 Leu Ser Ile Asn Thr Leu Val Lys Ile Ser Lys Ser Ala Gly Ala Met
  65                  70                  75                  80
 Leu Lys Pro His Ala Pro Lys Leu Ile Pro Ala Leu Leu Glu Ser Leu
                  85                  90                  95    
 Ser Val Leu Glu Pro Gln Val Leu Asn Tyr Leu Ser Leu Arg Ala Thr
             100                 105                 110        
 Glu Gln Glu Lys Ala Ala Met Asp Ser Ala Arg Leu Ser Ala Ala Lys
         115                 120                 125            
 Ser
    



      <210> 571
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 571
 Ala Leu Thr Ser Pro Thr Leu Pro Gln Pro Leu Pro Gly Ala Thr Val
   1               5                  10                  15    
 Ile Glu Pro Leu Asp Asp Ile Ser Ala Val Thr Asp Ile Leu Thr His
              20                  25                  30        
 Arg Glu Gly Ala Arg Leu Glu Thr Pro Pro Pro Trp Leu Ala Met Phe
          35                  40                  45            
 Thr Asp Gln Pro Ala Leu Pro Asn Pro Cys Ser Pro Ala Ser Val Gly
      50                  55                  60                
 Pro
  65



      <210> 572
      <211> 227
      <212> PRT
      <213> Homo sapiens


      <400> 572
 Gly Pro Arg Gln Lys Arg Lys Pro Lys Ser Ser Ser Ser Gly Thr Lys
   1               5                  10                  15    
 Gly Lys Gly Asn Leu Glu Pro Tyr Leu Asn Phe Leu Pro Leu Ser Gln
              20                  25                  30        
 Val Asn Asn Lys Phe Gly Leu Arg Cys Lys Asn Cys Lys Thr Asn Ile
          35                  40                  45            
 His Glu His Cys Gln Ser Tyr Val Glu Met Gln Arg Cys Phe Gly Lys
      50                  55                  60                
 Ile Pro Pro Gly Phe His Arg Ala Tyr Ser Ser Pro Leu Tyr Ser Asn
  65                  70                  75                  80
 Gln Gln Tyr Ala Cys Val Lys Asp Leu Ser Ala Ala Asn Arg Asn Asp
                  85                  90                  95    
 Pro Val Phe Glu Thr Leu Arg Thr Gly Val Ile Met Ala Asn Lys Glu
             100                 105                 110        
 Arg Lys Lys Gly Gln Ala Asp Lys Lys Asn Pro Val Ala Ala Met Met
         115                 120                 125            
 Glu Glu Glu Pro Glu Ser Ala Arg Pro Glu Glu Gly Lys Pro Gln Asp
     130                 135                 140                
 Gly Asn Pro Glu Gly Asp Lys Lys Ala Glu Lys Lys Thr Pro Asp Asp
 145                 150                 155                 160
 Lys His Lys Gln Pro Gly Phe Gln Gln Ser His Tyr Phe Val Ala Leu
                 165                 170                 175    
 Tyr Arg Phe Lys Ala Leu Glu Lys Asp Asp Leu Asp Phe Pro Pro Gly
             180                 185                 190        
 Glu Lys Ile Thr Val Ile Asp Asp Ser Asn Glu Glu Trp Gly Arg Gly
         195                 200                 205            
 Lys Ile Gly Glu Lys Val Gly Phe Phe Pro Ser Asn Phe Ile Ile Trp
     210                 215                 220                
 Gly Pro Ala
 225        



      <210> 573
      <211> 40
      <212> PRT
      <213> Homo sapiens


      <400> 573
 Phe Arg Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys Val
   1               5                  10                  15    
 Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe
              20                  25                  30        
 Leu Ser Phe Pro Thr Thr Cys Ile
          35                  40



      <210> 574
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 574
 Arg Thr Asp Ser Ser Thr Thr Asn Arg Glu Ser Val Asn Ser Glu Asp
   1               5                  10                  15    
 Gly Asp Ala Lys Glu Pro Pro Tyr Arg Gly Pro Phe Cys Gly Arg Asp
              20                  25                  30        
 Arg Val His Thr Asp Phe Thr Pro Ser Pro Tyr Asp Thr Asp Ser Leu
          35                  40                  45            
 Lys Leu Lys Lys Gly Asp Ile Ile Asp Ile Ile Ser Lys Pro Pro Met
      50                  55                  60                
 Gly Thr Trp Met Gly Leu Leu Asn Asn Lys Val Gly Thr Phe Lys Phe
  65                  70                  75                  80
 Ile Tyr Val Asp Val Leu Ser Glu Asp Glu Glu Lys Pro Lys Arg Pro
                  85                  90                  95    
 Thr Arg Arg Arg Arg Lys Gly Arg Pro Pro Gln Pro Lys Ser Val Glu
             100                 105                 110        
 Asp Leu Leu Asp Arg Ile Asn Ile Lys Glu His Met Pro Thr Cys Ile
         115                 120                 125            





      <210> 575
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 575
 Arg Val Val Gln Thr Val Asp Pro Ser Lys Ala Gln Ala Lys Pro His
   1               5                  10                  15    
 Thr Leu Trp Val Ala Phe Ala Lys Leu Tyr Glu Asp Asn Gly Gln Leu
              20                  25                  30        
 Asp Asp Ala Arg Val Ile Leu Glu Lys Ala Thr Lys Val Asn Phe Lys
          35                  40                  45            
 Gln Val Asp Asp Leu Ala Ser Val Trp Cys Gln Cys Gly Glu Leu Glu
      50                  55                  60                
 Leu Arg His Glu Asn Tyr Asp Glu Ala Leu Arg Leu Leu Arg Lys Ala
  65                  70                  75                  80
 Thr Ala Leu Pro Ala Arg Arg Ala Glu Tyr Phe Asp Gly Ser Glu Pro
                  85                  90                  95    
 Val Gln Asn Arg Val Tyr Lys Ser Leu Lys Val Trp Ser Met Leu Ala
             100                 105                 110        
 Asp Leu Glu Glu Ser Leu Gly Thr Phe Gln Ser Thr Lys Ala Val Tyr
         115                 120                 125            
 Asp Arg Ile Leu Asp Leu Arg Ile Ala Thr Pro His Val Phe Gly Arg
     130                 135                 140                
 Ser Glu Asp Gln Ala Ser Thr Arg
 145                 150        



      <210> 576
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 576
 Cys Arg Glu Cys Thr Glu Gly Glu His Ala Glu Leu Pro Thr Val Pro
   1               5                  10                  15    
 Leu Lys Asp Val Val Glu Gln His Lys Ala Ser Leu Gln Val Gln Leu
              20                  25                  30        
 Asp Ala Val Asn Lys Arg Leu Pro Glu Ile Asp Ser Ala Leu Gln Phe
          35                  40                  45            
 Ile Ser Glu Ile Ile His Gln Leu Thr Asn Gln Lys Ala Ser Ile Val
      50                  55                  60                
 Asp Asp Ile His Ser Thr Phe Asp Glu Leu Gln Lys Thr Leu Asn Val
  65                  70                  75                  80
 Arg Lys Ser Val Leu Leu Met Glu Leu Glu Val Asn Tyr Gly Leu Lys
                  85                  90                  95    
 His Lys Val Leu Gln Ser Gln Leu Asp Thr Leu Leu Gln Gly Gln Glu
             100                 105                 110        
 Ser Ile Lys Ser Cys Ser Asn Phe Thr Ala Gln Thr Leu Asn His Gly
         115                 120                 125            
 Thr Lys Ala
     130    



      <210> 577
      <211> 131
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(130)
      <223> Xaa = any amino acid or nothing 


      <400> 577
 Leu Leu Tyr Thr Tyr Val Leu Leu Ala Ser Gly Val Trp Val Ala Xaa
   1               5                  10                  15    
 Ala Tyr His Arg Leu Ile Glu Asn Asn Arg Asn Gln Ile Ile Gln Ala
              20                  25                  30        
 Leu Leu Ile Thr Ile Leu Leu Gly Leu Tyr Phe Thr Leu Leu Gln Ala
          35                  40                  45            
 Ser Glu His Leu Gln Ser Pro Phe Thr Ile Ser Asp Gly Ile Tyr Gly
      50                  55                  60                
 Ser Thr Phe Phe Val Ala Thr Gly Phe His Arg Leu His Val Ile Ile
  65                  70                  75                  80
 Gly Ser Thr Leu Leu Thr Ile Cys Phe Ile Pro Gln Leu Ile Phe Asp
                  85                  90                  95    
 Phe Thr Ser Lys His His Phe Gly Ile Gln Ala Ala Val Xaa Tyr Trp
             100                 105                 110        
 His Leu Val Asp Gly Val Xaa Leu Phe Met His Gly Ser Ile Xaa Trp
         115                 120                 125            
 Val Ala
     130



      <210> 578
      <211> 598
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(588)
      <223> Xaa = any amino acid or nothing 


      <400> 578
 Ile Ser His Ser Leu Ser Thr Gln Asp Pro Asn Gly Glu Ser Ile Ile
   1               5                  10                  15    
 Tyr Asn Ser Ser Phe Ser Ala Val Asp Ser Phe Ala Val Ser Ser Pro
              20                  25                  30        
 Ala Ser Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys
          35                  40                  45            
 Tyr Ser Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr
      50                  55                  60                
 Glu Thr Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu
  65                  70                  75                  80
 Lys Glu Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu
                  85                  90                  95    
 Lys Lys Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu
             100                 105                 110        
 Leu Met Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val
         115                 120                 125            
 Glu Glu Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser
     130                 135                 140                
 Asp Asp Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr
 145                 150                 155                 160
 Phe Lys Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe
                 165                 170                 175    
 Asp Glu Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg
             180                 185                 190        
 Arg Val Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu
         195                 200                 205            
 Asn Phe Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val
     210                 215                 220                
 Ser Arg Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys
 225                 230                 235                 240
 Lys Leu Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp
                 245                 250                 255    
 Lys Tyr Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu
             260                 265                 270        
 Gly Val Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu
         275                 280                 285            
 Arg Phe Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln
     290                 295                 300                
 Tyr Val Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala
 305                 310                 315                 320
 Gly Ser Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu
                 325                 330                 335    
 Leu Lys Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu
             340                 345                 350        
 Tyr Cys Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn
         355                 360                 365            
 Val Ala Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu
     370                 375                 380                
 Ser Arg Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met
 385                 390                 395                 400
 Lys Asp Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln
                 405                 410                 415    
 Arg Leu Thr Glu Ser Pro Trp Leu Leu Trp Val Gly Gln Pro Ser Thr
             420                 425                 430        
 Asp Trp Ser Gly Asn Met Arg Asp Phe Met Lys Ala Gln Ala Tyr Gln
         435                 440                 445            
 Pro Gly Lys Asp Ile Leu Pro Asn Tyr Tyr Ala Ser Gln Lys Lys Thr
     450                 455                 460                
 Phe Glu Ile Asn Pro Arg Pro Pro Leu Ile Arg Asp Met Leu Arg Arg
 465                 470                 475                 480
 Ile Lys Glu Asp Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val
                 485                 490                 495    
 Leu Val Xaa Asn Arg Gln Arg Leu Gly Ser Gly Tyr Leu Phe Thr Gln
             500                 505                 510        
 Thr Leu Lys Ala Tyr Gly Asp Trp Arg Leu Glu Arg Met Leu Arg Leu
         515                 520                 525            
 Ser Phe Glu His Leu Thr Pro Asp Ala Lys Gly Gly Arg Arg Ala Pro
     530                 535                 540                
 Lys Glu Glu Pro Xaa Lys Arg Gln Gln Lys Asp Thr Ser Arg Lys Thr
 545                 550                 555                 560
 Gln Ser Arg Asp Glu Glu Met Gln Glu Met Gly Trp Trp Glu Thr Asp
                 565                 570                 575    
 Glu Glu Glu Glu Thr Ser Gln Arg Asn Pro Thr Ala
             580                 585            



      <210> 579
      <211> 143
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(142)
      <223> Xaa = any amino acid or nothing 


      <400> 579
 Ile Ala Ser Gly Arg Pro Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
   1               5                  10                  15    
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
              20                  25                  30        
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
          35                  40                  45            
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
      50                  55                  60                
 Phe Phe Phe Phe Phe Phe Phe Xaa Phe Tyr Ile Leu Lys Ile Phe Phe
  65                  70                  75                  80
 Phe Phe Phe Ile Leu Glu Ile Leu Cys Tyr Leu Ser Asn Tyr Gly Val
                  85                  90                  95    
 Gly Val Thr Tyr Ile Arg Met Ser Tyr Tyr Lys Xaa Met Leu Glu Ser
             100                 105                 110        
 Tyr Phe Phe Phe Thr Ile Asn Ile Phe Phe Ile Gly Asn Asn Tyr Leu
         115                 120                 125            
 Ile Ser Leu Ile Tyr Asn Ile Tyr Ala Val Lys Arg Gln Leu
     130                 135                 140        



      <210> 580
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 580
 Gly Ser Thr Thr Pro Ala Met Glu Phe Ala Ser Leu Phe Lys Lys Ile
   1               5                  10                  15    
 Leu Leu Ile Asp Cys Arg Asp Arg Gly Leu Ala Leu Leu Pro Arg Leu
              20                  25                  30        
 Val Leu Ser Ser Trp Pro Gln Val Ile Phe Leu Pro Trp Pro Pro Lys
          35                  40                  45            
 Phe Leu Gly Leu Arg Thr
      50                



      <210> 581
      <211> 90
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(90)
      <223> Xaa = any amino acid or nothing 


      <400> 581
 Glu Ser Ser Cys Asp Trp Leu Asn Ala Tyr Leu Thr Leu Val Arg Cys
   1               5                  10                  15    
 Ala Gln Asp Xaa Ala Asp Tyr Phe Ala Glu Arg Leu Tyr Lys Ser Met
              20                  25                  30        
 Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Ile Val Thr
          35                  40                  45            
 Arg Ala Glu Val Asp Leu His Gly Ile Lys Ala Lys Phe Gln Glu Lys
      50                  55                  60                
 Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Phe Gly Asp
  65                  70                  75                  80
 Phe Arg Lys Leu Leu Val Ala Leu Leu His
                  85                  90



      <210> 582
      <211> 149
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(149)
      <223> Xaa = any amino acid or nothing 


      <400> 582
 Leu Tyr Ile Phe Ser Pro Ser Arg Leu Ile Phe Phe Arg Gly Phe Ser
   1               5                  10                  15    
 Phe Phe Phe Phe Pro Pro Lys Lys Ile Phe Phe Leu Lys Ile Phe Pro
              20                  25                  30        
 Asn Asp Phe Phe Phe Pro Ser His Phe Phe Lys Ile Pro Ser Leu Gly
          35                  40                  45            
 Phe Phe Phe Tyr Thr Phe Phe Ile Arg Lys Ile Phe Phe Phe Phe Pro
      50                  55                  60                
 Ile Ile Tyr Phe Ser Pro Pro Gly Phe Phe Phe Xaa Ser Pro Pro Phe
  65                  70                  75                  80
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
                  85                  90                  95    
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
             100                 105                 110        
 Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe
         115                 120                 125            
 Gly Trp Tyr Lys Gln Arg Pro Ser Gln Ala Arg Val Trp Thr Ala Ser
     130                 135                 140                
 Leu Asp Phe Thr Leu
 145                



      <210> 583
      <211> 208
      <212> PRT
      <213> Homo sapiens


      <400> 583
 Gly Asp Leu Pro Asp Pro Cys Lys Phe Asn Phe Phe Pro Ile Pro Gly
   1               5                  10                  15    
 Pro Ser Leu Ser Ser Pro Pro Ser Pro Trp Ile Met Phe Lys Lys Phe
              20                  25                  30        
 Asp Glu Lys Glu Asn Val Ser Asn Cys Ile Gln Leu Lys Thr Ser Val
          35                  40                  45            
 Ile Lys Gly Ile Lys Asn Gln Leu Ile Glu Gln Phe Pro Gly Ile Glu
      50                  55                  60                
 Pro Trp Leu Asn Gln Ile Met Pro Lys Lys Asp Pro Val Lys Ile Val
  65                  70                  75                  80
 Arg Cys His Glu His Ile Glu Ile Leu Thr Val Asn Gly Glu Leu Leu
                  85                  90                  95    
 Phe Phe Arg Gln Arg Glu Gly Pro Phe Tyr Pro Thr Leu Arg Leu Leu
             100                 105                 110        
 His Lys Tyr Pro Phe Ile Leu Pro His Gln Gln Val Asp Lys Gly Ala
         115                 120                 125            
 Ile Lys Phe Val Leu Ser Gly Ala Asn Ile Met Cys Pro Gly Leu Thr
     130                 135                 140                
 Ser Pro Gly Ala Lys Leu Tyr Pro Ala Ala Val Asp Thr Ile Val Ala
 145                 150                 155                 160
 Ile Met Ala Glu Gly Lys Gln His Ala Leu Cys Val Gly Val Met Lys
                 165                 170                 175    
 Met Ser Ala Glu Asp Ile Glu Lys Val Asn Lys Gly Ile Gly Ile Glu
             180                 185                 190        
 Asn Ile His Tyr Leu Asn Asp Gly Leu Trp His Met Lys Thr Tyr Lys
         195                 200                 205            





      <210> 584
      <211> 116
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(113)
      <223> Xaa = any amino acid or nothing 


      <400> 584
 Phe Phe Phe Phe Glu Asp Lys Val Ser Leu Cys His Pro Arg Trp Glu
   1               5                  10                  15    
 Cys Ser Asp Asp Ile Thr Ala His Cys Ser Leu Asn Leu Gly Phe Lys
              20                  25                  30        
 Xaa Ser Ser His Leu Ser Leu Pro Lys Xaa Leu Cys Leu Leu Gly Thr
          35                  40                  45            
 Gln His Tyr Ala Pro Ala Asn Phe Leu Tyr Phe Val Phe Phe Val Glu
      50                  55                  60                
 Thr Gly Phe Arg His Val Gly Gln Ala Gly Leu Glu His Leu Gly Ser
  65                  70                  75                  80
 Thr Asp Pro Pro Ala Ser Ala Phe Pro Lys Cys Trp Asp Tyr Arg Cys
                  85                  90                  95    
 Glu Pro Pro Cys Ser Thr Arg Phe Tyr Tyr Leu Ser Xaa Leu Asn Phe
             100                 105                 110        
 Gly
    



      <210> 585
      <211> 147
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(146)
      <223> Xaa = any amino acid or nothing 


      <400> 585
 Ile Pro Pro Thr Met Gly Asn Leu Ala Leu Gly Gly Lys Asn Ser Ser
   1               5                  10                  15    
 Arg Gly Phe Val Asp Ser Leu Ile Cys Asn Ser Ser Arg Ala Phe Met
              20                  25                  30        
 Asp Trp Arg Ala Leu Leu Ser Ser Leu Asn Asp Phe Ala Ser Leu Ser
          35                  40                  45            
 Phe Ala Glu Ser Trp Asp Asn Val Gly Leu Leu Val Glu Pro Ser Pro
      50                  55                  60                
 Pro His Thr Val Asn Thr Leu Phe Leu Thr Asn Asp Leu Thr Asp Glu
  65                  70                  75                  80
 Val Met Asp Glu Val Leu Leu Lys Lys Ala His Leu Ile Leu Ser Tyr
                  85                  90                  95    
 His Pro Ser Ile Phe Arg Pro Met Lys Arg Ile Thr Trp Asn Thr Trp
             100                 105                 110        
 Lys Glu Leu Leu Val Ile Arg Ala Leu Glu Asn Arg Val Gly Ile Tyr
         115                 120                 125            
 Ser Pro Tyr Thr Thr Xaa Glu Ala Ala Pro Gln Gly Val Asn Asn Trp
     130                 135                 140                
 Val Ala
 145    



      <210> 586
      <211> 345
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(341)
      <223> Xaa = any amino acid or nothing 


      <400> 586
 Asp Gly Val Ser Leu Leu Leu Tyr Arg Leu Glu Tyr Asn Gly Val Ile
   1               5                  10                  15    
 Ser Pro His Cys Asn Pro Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser
              20                  25                  30        
 Arg Val Ala Gly Ile Thr Gly Met Arg His His Ala Gln Leu Ile Phe
          35                  40                  45            
 Val Phe Leu Val Glu Thr Gly Phe His His Val Gly Gln Ala Gly Leu
      50                  55                  60                
 Glu Leu Leu Thr Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala
  65                  70                  75                  80
 Gly Ile Thr Gly Met Ser His His Ala Trp Pro Asp Val Asn Tyr Leu
                  85                  90                  95    
 Lys Asn Phe Gln Val Ile Leu Met Gly Gln Gly Trp Asn Pro Cys Ser
             100                 105                 110        
 Gly Pro Ile Arg Ala Pro Gly Cys His Lys Arg Met His Ala Leu Thr
         115                 120                 125            
 Pro Val Gly Leu Gly Gly Phe Gly Asn Val Leu Leu Leu Phe Xaa Asp
     130                 135                 140                
 Gly Cys Leu Ser Val Ala His Pro Gly Ala Gln Trp His Asp His Ser
 145                 150                 155                 160
 Ser Leu Gln Pro Arg Pro Pro Gly Leu Arg Tyr Pro Pro Ala Ser Ala
                 165                 170                 175    
 Ser Xaa Val Ser Ala Ser Gly Phe His Asp Asp Leu Gly Pro Arg His
             180                 185                 190        
 Thr Thr Leu Val Leu Phe Arg Gly Gln Ser Cys Thr Arg Ser Pro Ser
         195                 200                 205            
 Ala Thr Ala Pro Pro Arg Ser Thr Asp Met Gln Ser Xaa Ala Ala Leu
     210                 215                 220                
 Phe Pro Arg Gly Ser Cys Val Gly Phe Leu Gly Pro Ser Val Asp Tyr
 225                 230                 235                 240
 Arg Thr Pro Ala Glu Asp Leu Leu Gly Met Pro His Cys Leu Cys Phe
                 245                 250                 255    
 Pro Ser Ser Leu Asn Thr Gln Ser Gly Leu Ala Met Met Pro Leu Cys
             260                 265                 270        
 Leu Leu Ala Ser Pro Pro Leu Glu Gln Pro Ser Trp His Ala Thr Leu
         275                 280                 285            
 Leu Ala Ala Gly His Cys Ala Phe Cys Leu Tyr Arg Ser Ala Val Met
     290                 295                 300                
 Leu Pro Lys Xaa Gln Gln Gln Gln Gln Gln Gln Arg Leu Gly Thr Trp
 305                 310                 315                 320
 Leu Met Pro Val Phe Pro Ala Val Arg Asp Gln Pro Gly Gln His Gly
                 325                 330                 335    
 Glu Thr Leu Ser Leu
             340    



      <210> 587
      <211> 78
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(77)
      <223> Xaa = any amino acid or nothing 


      <400> 587
 Val Asp His Leu Arg Ser Glu Val Xaa Asp Gln Pro Gly Gln His Ile
   1               5                  10                  15    
 Val Lys Pro Arg Leu Tyr Xaa Lys Ile Gln Lys Leu Ala Gly His Gly
              20                  25                  30        
 Gly Ala Cys Leu Xaa Ser Pro Leu Leu Gly Lys Leu Arg Gln Glu Asn
          35                  40                  45            
 Arg Leu Asn Pro Gly Ala Arg Ser Cys Ser Glu Pro Arg Ser His Tyr
      50                  55                  60                
 Cys Thr Pro Ala Trp Gly Thr Glu Xaa Asn Ser Val Ser
  65                  70                  75        



      <210> 588
      <211> 108
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(107)
      <223> Xaa = any amino acid or nothing 


      <400> 588
 Gly Tyr Cys Phe Ser Arg Arg Ser Gly Ser Met Ala Leu Trp Arg Ala
   1               5                  10                  15    
 Tyr Gln Arg Ala Leu Ala Ala His Pro Trp Lys Val Gln Val Leu Thr
              20                  25                  30        
 Ala Asp Phe Trp Gly Gly Arg Gln His Cys Trp Pro His Ala Ser Ser
          35                  40                  45            
 Tyr Thr Cys Arg Pro Arg Pro Pro Gly Leu Lys Asp Ile Ala Ser Cys
      50                  55                  60                
 Ser Ser Leu Gln Glu Ala Thr Ser Cys Pro Ser Ala Phe Cys Ala Xaa
  65                  70                  75                  80
 Asn Ser Lys Ala Thr Lys Gln Leu Val Glu Arg Arg Gly Leu Gln Glu
                  85                  90                  95    
 His Gln Arg Gly Arg Thr Leu Thr Met Val Ser
             100                 105        



      <210> 589
      <211> 174
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(172)
      <223> Xaa = any amino acid or nothing 


      <400> 589
 Val Gly Ser Gln Gly Leu Val Pro Lys Lys Asn Arg Pro Ala Gly Lys
   1               5                  10                  15    
 Asp Leu Gly Ala Pro Ser Gly Gly Pro Pro Arg Lys Cys Ile Pro Trp
              20                  25                  30        
 Gln Gly Leu Leu Leu Thr Ala Ser Leu Leu Ala Leu Xaa Glu Ala Pro
          35                  40                  45            
 Thr Thr Ala Trp Leu Phe Ile Ala Ser Ala Pro Tyr Glu Val Ala Glu
      50                  55                  60                
 Gly Glu Asn Val His Leu Ser Val Val Tyr Leu Arg Glu Asn Leu Tyr
  65                  70                  75                  80
 Ser Tyr Gly Trp Tyr Lys Gly Lys Thr Val Glu Pro Asn Gln Leu Ile
                  85                  90                  95    
 Ala Ala Tyr Val Ile Asp Thr His Val Arg Thr Pro Gly Pro Ala Tyr
             100                 105                 110        
 Ser Gly Arg Glu Thr Ile Ser Pro Ser Gly Asp Leu His Phe Gln Asn
         115                 120                 125            
 Val Thr Leu Glu Asp Thr Gly Tyr Tyr Asn Leu Gln Val Thr Tyr Arg
     130                 135                 140                
 Asn Ser Gln Ile Glu Gln Ala Ser His His Leu Arg Val Tyr Glu Ser
 145                 150                 155                 160
 Val Ala Gln Pro Ser Ile Gln Ala Ser Ser Cys Ile
                 165                 170        



      <210> 590
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 590
 Val Thr Arg Ala His Cys Trp Lys Met Glu Arg Ser Leu Arg Gln Ser
   1               5                  10                  15    
 Leu Leu Glu Pro Val Pro Pro Ser Leu Pro Asn Ser Val Leu Gly Trp
              20                  25                  30        
 Cys Ala Glu Leu Arg Val Leu Cys Lys Leu Glu Glu Asn Val Gln Ala
          35                  40                  45            
 Thr Asn Ser Pro Ser Glu Ala Glu Glu Phe Gln Leu Glu Val Ser Gly
      50                  55                  60                
 Leu Leu Gly Glu Met Asn Cys Pro Tyr Leu Ser Leu Thr Ser Gly Asp
  65                  70                  75                  80
 Val Thr Lys Arg Leu Leu Ile Gln Lys Asn Cys Leu Leu Leu Leu Thr
                  85                  90                  95    
 Tyr Leu Ile Ser Glu Leu Glu Ala Ala Arg Met Leu Cys Val Asn Ala
             100                 105                 110        
 Pro Pro Lys Lys Ser
         115        



      <210> 591
      <211> 39
      <212> PRT
      <213> Homo sapiens


      <400> 591
 Asp Arg Val Ser Leu Leu Leu Pro Arg Leu Asp Cys Asn Gly Thr Ile
   1               5                  10                  15    
 Leu Val His Cys Gly Leu Arg Leu Pro Gly Phe Lys Arg Phe Ser Cys
              20                  25                  30        
 Leu Ser Leu Pro Ser
          35        



      <210> 592
      <211> 123
      <212> PRT
      <213> Homo sapiens


      <400> 592
 Gln Pro Gln Thr Asp Thr Met Val His Leu Thr Pro Glu Glu Lys Ala
   1               5                  10                  15    
 Ala Ala Thr Val Leu Trp Gly Lys Gly Asn Val Asp Glu Val Gly Gly
              20                  25                  30        
 Glu Ala Leu Val Lys Leu Ile Gly Ala Tyr Pro Trp Thr Gln Arg Phe
          35                  40                  45            
 Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp Ala Val Met Gly Asn
      50                  55                  60                
 Pro Asn Gly Lys Ala His Gly Ala Lys Val Leu Gly Ala Phe Ser Asp
  65                  70                  75                  80
 Gly Leu Ala His Leu Asp Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser
                  85                  90                  95    
 Glu Leu His Cys Asp Lys Leu His Val Asp Ala Glu Asn Phe Met Leu
             100                 105                 110        
 Leu Gly Asn Val Leu Val Cys Glu Leu Ala
         115                 120        



      <210> 593
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 593
 Ile Ile Ser Val Lys Arg Trp Met Glu Pro Gly Gln His Gly Lys Thr
   1               5                  10                  15    
 Pro Pro Pro Leu Lys Ile Gln Arg Leu Ala Gly His Ser Gln Val Leu
              20                  25                  30        
 Arg Gly Leu Arg His Lys Asn Cys Leu Asn Pro Gly Asp Gly Gly Cys
          35                  40                  45            
 Ser Glu Pro Arg Val Phe His Cys Thr Pro Ala Trp Val Thr Glu Glu
      50                  55                  60                
 Asp Pro Val Ser Leu Ser Lys Lys Arg Glu Met Asp Gly Asn Asn Thr
  65                  70                  75                  80
 Thr Phe Thr Pro Ser Gln Leu
                  85        



      <210> 594
      <211> 139
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(139)
      <223> Xaa = any amino acid or nothing 


      <400> 594
 Pro Gln Thr Gln Arg Glu Pro Thr Met Gly Leu Ser Ala Ala Asp Xaa
   1               5                  10                  15    
 Thr Asn Val Xaa Ala Gly Trp Gly Lys Val Gly Ala His Ala Gly Glu
              20                  25                  30        
 Tyr Gly Ala Glu Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr
          35                  40                  45            
 Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Tyr Ala Gln Asp
      50                  55                  60                
 Lys Gly His Gly Met Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala
  65                  70                  75                  80
 His Val Asp Asp Met Pro Asn Ala Leu Tyr Ala Leu Ser Asp Leu His
                  85                  90                  95    
 Ala His Lys Leu Xaa Val Asp Pro Val Asn Phe Lys Leu Leu Asn His
             100                 105                 110        
 Cys Leu Val Val Thr Leu Ala Cys His Leu Leu Ala Glu Val Thr Pro
         115                 120                 125            
 Gly Val His Ala Phe Leu Asp Lys Phe Pro Gly
     130                 135                



      <210> 595
      <211> 121
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(121)
      <223> Xaa = any amino acid or nothing 


      <400> 595
 Ser Tyr Pro Glu Thr Trp Ala Leu Glu Asp Ala Ser Leu Glu Gln Met
   1               5                  10                  15    
 Asp Asn Gly Tyr Trp Gly Tyr Met Met Thr Asp Pro Val Thr Leu Asn
              20                  25                  30        
 Val Gly Gly His Leu Tyr Thr Thr Ile Leu Thr Thr Leu Thr Arg Tyr
          35                  40                  45            
 Pro Asp Ser Met Leu Gly Ala Met Asn Gly Gly Asp Phe Pro Thr Ala
      50                  55                  60                
 Xaa Asp Pro Gln Gly Asn Tyr Phe Ile Asp Leu Asp Gly Pro Leu Phe
  65                  70                  75                  80
 Arg Tyr Val Leu Asn Phe Leu Arg Thr Ser Glu Leu Thr Leu Pro Leu
                  85                  90                  95    
 Asp Phe Lys Glu Phe Asp Leu Leu Leu Lys Xaa Ser Asp Phe Tyr Gln
             100                 105                 110        
 Ile Glu Pro Leu Ile Gln Cys Ile Asn
         115                 120    



      <210> 596
      <211> 86
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(86)
      <223> Xaa = any amino acid or nothing 


      <400> 596
 Ser Phe Arg Arg Pro Met Ala Ser Ala Ser Thr Gln Pro Ala Ala Leu
   1               5                  10                  15    
 Ser Ala Glu Gln Ala Lys Ala Ser Ile His Xaa Phe Leu Ala Leu Ser
              20                  25                  30        
 Ala Gly Pro Ala Val Cys Ser Pro Thr Pro Thr Arg Asp Ala Ser Leu
          35                  40                  45            
 Gly Cys Phe Trp Arg Ala Val Val Leu Ala Glu Val Ile Gln Ala Phe
      50                  55                  60                
 Ser Ala Pro Glu Asn Ala Val Arg Met Asp Glu Ala Arg Asp Asn Ala
  65                  70                  75                  80
 Cys Asn Asp Met Gly Lys
                  85    



      <210> 597
      <211> 34
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(34)
      <223> Xaa = any amino acid or nothing 


      <400> 597
 Glu His Arg Pro Gly Val Val Ala His Ala Cys Asn Pro Ser Thr Ser
   1               5                  10                  15    
 Gly Gly Gln Gly Glu Trp Ile Thr Xaa Gly Gln Glu Phe Lys Thr Ser
              20                  25                  30        
 Leu Gly
        



      <210> 598
      <211> 58
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(58)
      <223> Xaa = any amino acid or nothing 


      <400> 598
 Lys Lys Lys Lys Lys Lys Lys Lys Arg Gly Glu Ile Gly Lys Phe Tyr
   1               5                  10                  15    
 Ser Leu Leu Glu Glu Leu Thr Ala Arg Ser Trp Phe Ser Cys Phe Phe
              20                  25                  30        
 Ile Phe Xaa Asp Lys Gln Gly Leu Pro Trp Trp Leu Gly Ile Ser Tyr
          35                  40                  45            
 Lys Gly Ser Gly Gln Tyr Asp Ile Gln Ala
      50                  55            



      <210> 599
      <211> 87
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(87)
      <223> Xaa = any amino acid or nothing 


      <400> 599
 Gly Ala Glu Val Ala Pro Leu Ser Ile Tyr Phe Thr Gln Val Pro Val
   1               5                  10                  15    
 Val His Ile Tyr Ser Val Ile Met Thr Arg Leu Val Lys Leu Ala Ala
              20                  25                  30        
 Arg Lys Gln Ser Pro Phe Phe Leu Ala Val Phe Gly Ile Tyr His Leu
          35                  40                  45            
 Leu Ile Thr Ile His Phe Xaa Arg Gln Lys Lys Lys Ile Tyr Leu Ser
      50                  55                  60                
 Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Ser Ile Tyr Leu Asn
  65                  70                  75                  80
 Asp Leu Thr Glu Glu Asn Cys
                  85        



      <210> 600
      <211> 68
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(68)
      <223> Xaa = any amino acid or nothing 


      <400> 600
 Asn Phe Cys Thr Thr Ala Ser Xaa Gly Arg Gly Cys Ser Glu Pro Arg
   1               5                  10                  15    
 Xaa Arg His Cys Thr Pro Ala Trp Val Thr Asp Tyr Asp Ser Ile Ser
              20                  25                  30        
 Asn Lys Asn Xaa Thr Gly Gly Asp Phe Ile Lys Asn Ile Met Arg Asn
          35                  40                  45            
 Leu Gln Asp Ala Ile Ile Gly Ser Val Tyr Phe His Val Glu Arg Val
      50                  55                  60                
 Asn Arg Leu Asn
  65            



      <210> 601
      <211> 74
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(74)
      <223> Xaa = any amino acid or nothing 


      <400> 601
 Glu Asp His His Ala Gly Thr Leu Ile Thr Ala Leu Ser Ser His Xaa
   1               5                  10                  15    
 Phe Phe Thr Xaa Val Gly Leu Glu Ile Asn Met Leu Ala Phe Ile Pro
              20                  25                  30        
 Val Leu Thr Lys Lys Lys Lys Lys Lys Arg Gly Gly Pro Phe Lys Gly
          35                  40                  45            
 Thr Lys Phe Lys Ala Arg Gly Gly Gly Arg Lys Asn Phe Phe Lys Gly
      50                  55                  60                
 Ala Pro Lys Leu Asn Ser Gly Ala Gly Val
  65                  70                



      <210> 602
      <211> 131
      <212> PRT
      <213> Homo sapiens


      <400> 602
 Val Ser Glu Glu Lys Leu Leu Val Arg Ile Pro Arg Val Ile Gly Ala
   1               5                  10                  15    
 Thr Tyr Ser Leu Ala Asn Glu Arg Leu Arg Ala Leu Glu Asp Ile Glu
              20                  25                  30        
 Arg Glu Ile Gly Ala Ile Leu Gln Asn Ala Gly Thr Val Ile Leu Glu
          35                  40                  45            
 Leu Ser Lys Glu Lys Thr Asn Glu Arg Leu Leu Asp Arg Gln Ala Ala
      50                  55                  60                
 Ala Phe Thr Ala Ser Val Gln His Val Glu Ala Glu Leu Ser Ala Gln
  65                  70                  75                  80
 Ile Arg Tyr Leu Thr Gln Val Ala Thr Gly Gln Pro His Glu Gly Ser
                  85                  90                  95    
 Ser Tyr Ser Ser Arg Lys Asp Cys Gln Met Ala Leu Lys Arg Val Asp
             100                 105                 110        
 Tyr Ala Arg Leu Lys Leu Ser Asp Val Ala Arg Thr Cys Glu Gln Met
         115                 120                 125            
 Leu Glu Asn
     130    



      <210> 603
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 603
 Gly Thr Tyr Ala Leu Lys Ile Ile Gly His Lys Arg Ser Ser Glu Gly
   1               5                  10                  15    
 Val Gln Arg His His Leu Lys Gly Ile Thr Glu Ile Leu Met Asn Arg
              20                  25                  30        
 Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser Glu Leu Leu
          35                  40                  45            
 Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg Val Leu Leu
      50                  55                  60                
 Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala Asp Leu Leu
  65                  70                  75                  80
 Asp Arg Glu His Met Ser
                  85    



      <210> 604
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 604
 Gly Thr Tyr Ala Leu Lys Ile Ile Gly His Lys Arg Ser Ser Glu Gly
   1               5                  10                  15    
 Val Gln Arg His His Leu Lys Gly Ile Thr Glu Ile Leu Met Asn Arg
              20                  25                  30        
 Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser Glu Leu Leu
          35                  40                  45            
 Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg Val Leu Leu
      50                  55                  60                
 Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala Asp Leu Leu
  65                  70                  75                  80
 Asp Arg Glu His Met Ser
                  85    



      <210> 605
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 605
 Gly Thr Tyr Ala Leu Lys Ile Ile Gly His Lys Arg Ser Ser Glu Gly
   1               5                  10                  15    
 Val Gln Arg His His Leu Lys Gly Ile Thr Glu Ile Leu Met Asn Arg
              20                  25                  30        
 Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser Glu Leu Leu
          35                  40                  45            
 Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg Val Leu Leu
      50                  55                  60                
 Phe Arg Ser Gly Val Lys Gly Val Phe Cys Ala Gly Ala Asp Leu Leu
  65                  70                  75                  80
 Asp Arg Glu His Met Ser
                  85    



      <210> 606
      <211> 114
      <212> PRT
      <213> Homo sapiens


      <400> 606
 Cys Ser Ser Glu Asp Lys Glu Asp Ser Phe Tyr Pro Arg Asn Ser Lys
   1               5                  10                  15    
 Lys Lys Cys Lys Asp Phe Ser Lys His Gln Val Phe Cys Phe Val Leu
              20                  25                  30        
 Arg Arg Glu Ser Cys Ser Val Ala Arg Ala Gly Val Gln Trp Arg Asp
          35                  40                  45            
 Leu Gly Ser Leu Gln Ala Pro Pro Pro Gly Phe Thr Pro Phe Ser Trp
      50                  55                  60                
 Lys Gly Glu Asp Ala Val Ser Leu Asn Arg Ser Ile Ala Pro Gln Pro
  65                  70                  75                  80
 Glu Arg Gln Ser Glu Thr Leu Gly Ser Asn Arg Leu Arg Arg Trp Arg
                  85                  90                  95    
 Lys Asn Tyr Lys Ala Arg Arg Gly Gly His Met Pro Val Leu Gln Val
             100                 105                 110        
 Leu Ser
        



      <210> 607
      <211> 89
      <212> PRT
      <213> Homo sapiens


      <400> 607
 Arg Met Lys Thr Ile Leu Ser Asn Gln Thr Val Asp Ile Pro Glu Asn
   1               5                  10                  15    
 Val Asp Ile Thr Leu Lys Gly Arg Thr Gly Ile Val Lys Gly Pro Arg
              20                  25                  30        
 Gly Thr Leu Arg Arg Asp Phe Asn His Ile Asn Val Glu Leu Ser Leu
          35                  40                  45            
 Leu Gly Lys Lys Lys Lys Arg Leu Arg Val Asp Lys Trp Arg Gly Asn
      50                  55                  60                
 Thr Lys Glu Leu Ser Thr Asp Arg Thr Met Cys Ile His Cys His Asn
  65                  70                  75                  80
 Met Ile Met Val Val Ile His Val Trp
                  85                



      <210> 608
      <211> 32
      <212> PRT
      <213> Homo sapiens


      <400> 608
 Lys His Thr Leu Gly Trp Val Gln Trp Leu Met Pro Ala Ile Pro Ala
   1               5                  10                  15    
 Leu Trp Glu Ala Lys Val Gly Arg Ser Leu Glu Thr His Ala Ser Ala
              20                  25                  30        





      <210> 609
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 609
 Phe His Phe Phe Arg Lys Pro Pro Glu Ser Lys Lys Pro Ser Val Pro
   1               5                  10                  15    
 Glu Thr Glu Ala Asp Gly Phe Val Leu Leu Gly Asp Thr Thr Asp Glu
              20                  25                  30        
 Gln Arg Met Thr Ala Arg Gly Lys Thr Ser Asp Ile Glu Ala Asn Gln
          35                  40                  45            
 Pro Leu Glu Thr Asn Lys Glu Asn Ser Ser Ser Val Thr Val Ser Asp
      50                  55                  60                
 Pro Glu Met Glu Asn Lys Ala Gly Gln Thr Leu Glu Asn Ser Ser Leu
  65                  70                  75                  80
 Met Ala Glu Leu Leu Ser Asp Val Pro Val Thr Leu Ala Pro His Val
                  85                  90                  95    
 Leu Ala Gly
            



      <210> 610
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 610
 Leu Ala Leu Phe Tyr Pro Gln Ile Lys Ala Ile Ile Phe Phe Phe Tyr
   1               5                  10                  15    
 Leu Ile Asn Ala Ser Asn Gly Ser Ile Leu Phe Phe Ser Gly Pro Phe
              20                  25                  30        
 His Thr Cys Ser Leu Lys Ser Ser Gly Ala Leu Trp Cys Met Ile Phe
          35                  40                  45            
 Arg Gly Arg Phe His Ser Leu Val Cys Phe Ser Arg Leu Ser Gly Val
      50                  55                  60                
 Leu Met Glu Val Glu Glu His Glu Val Leu Gln Asp Ser Leu Asp Arg
  65                  70                  75                  80
 Cys Tyr Ser Thr Pro Pro Met Phe Phe Asp Ile Pro Asp
                  85                  90            



      <210> 611
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 611
 Asn Ser Ala Pro Glu Ala Gly Ser Cys Trp Lys Met Lys Val Asn Ile
   1               5                  10                  15    
 Ser Phe Pro Ala Thr Gly Cys Gln Lys Leu Ile Glu Val Asp Asp Glu
              20                  25                  30        
 Arg Lys Leu Arg Thr Phe Tyr Asp Asn Arg Met Ala Pro Glu Val Ala
          35                  40                  45            
 Val Asp Ala Leu Val Glu Glu Trp Lys Gly Tyr Val Val Arg Ile Ile
      50                  55                  60                
 Gly Gly Asn Asp Lys Gln Gly Phe Pro Met Lys His Gly Asp Leu Thr
  65                  70                  75                  80
 His Gly Arg Val Arg Leu Leu Leu Ser Lys Gly His Ser Cys Tyr Arg
                  85                  90                  95    
 Pro Arg Arg Thr Gly Glu Arg Lys Arg Lys Ser Leu Arg Gly Cys Ile
             100                 105                 110        
 Val Asp Ala Asn Leu Ser Val Leu
         115                 120



      <210> 612
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 612
 Ala Leu Ile Met Ser Phe Ile Phe Glu Gly Ile Tyr Asp Gly Phe Ser
   1               5                  10                  15    
 Ser Val Leu Gln Phe Leu Gly Leu Tyr Lys Lys Ser Gly Lys Leu Val
              20                  25                  30        
 Phe Leu Gly Leu Asp Asn Ala Gly Lys Thr Thr Leu Leu His Met Leu
          35                  40                  45            
 Lys Asp Asp Arg Leu Gly Gln His Val Pro Thr Leu His Pro Thr Ser
      50                  55                  60                
 Glu Glu Leu Thr Ile Ala Gly Met Thr Phe Thr Thr Phe Asp Leu Gly
  65                  70                  75                  80
 Gly His Glu Gln Ala Arg Arg Val Trp Lys Asn Tyr Leu Pro Ala Ile
                  85                  90                  95    
 Asn Gly Ile Val Phe Leu Val Asp Cys Ala Asp His Ser Arg Leu Val
             100                 105                 110        
 Glu Ser Lys Val Glu Leu Asn Ala
         115                 120



      <210> 613
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 613
 Arg Gly Ile Pro Arg Leu Glu Arg Pro Asn Pro Ser Leu Thr Leu Ala
   1               5                  10                  15    
 Pro Asp Thr Gln Asp Leu Phe Lys Leu Cys Cys Lys Cys Asn Lys Ser
              20                  25                  30        
 Asp Pro Val Pro Pro Leu Thr Arg Lys Lys Lys Lys Lys Lys Lys Lys
          35                  40                  45            
 Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys
      50                  55                  60                
 Lys Arg Gly Ala Leu
  65                



      <210> 614
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 614
 Glu Leu Ala Pro Leu Gln Ser Leu Arg Lys Gly Pro Gly Leu Leu Ser
   1               5                  10                  15    
 Pro Pro Arg Ala Cys Pro Val Pro Thr Pro Ala Val Ser Arg Thr Leu
              20                  25                  30        
 Leu Gly Asn Phe Glu Glu Ser Leu Leu Arg Gly Arg Phe Ala Pro Ser
          35                  40                  45            
 Gly His Ile Asp Gly Tyr Thr Ala Glu Ile Gly Ala Ser Gly Ser Tyr
      50                  55                  60                
 Cys Pro Gln His Val Thr
  65                  70



      <210> 615
      <211> 379
      <212> PRT
      <213> Homo sapiens


      <400> 615
 Val Pro Ala Gln Pro Pro Lys Ser Arg Leu Ser Arg Gly Glu Leu Leu
   1               5                  10                  15    
 Gly Leu Lys Arg Pro Val Leu Val Arg Pro Arg Trp Val Gly Ser Glu
              20                  25                  30        
 Gln Ala Glu Ala Thr Met Glu Gln Cys Ala Cys Val Glu Arg Glu Leu
          35                  40                  45            
 Asp Lys Val Leu Gln Lys Phe Leu Thr Tyr Gly Gln His Cys Glu Arg
      50                  55                  60                
 Ser Leu Glu Glu Leu Leu His Tyr Val Gly Gln Leu Arg Ala Glu Leu
  65                  70                  75                  80
 Ala Ser Ala Ala Leu Gln Gly Thr Pro Leu Ser Ala Thr Leu Ser Leu
                  85                  90                  95    
 Val Met Ser Gln Cys Cys Arg Lys Ile Lys Asp Thr Val Gln Lys Leu
             100                 105                 110        
 Ala Ser Asp His Lys Asp Ile His Ser Ser Val Ser Arg Val Gly Lys
         115                 120                 125            
 Ala Ile Asp Arg Asn Phe Asp Ser Glu Ile Cys Gly Val Val Ser Asp
     130                 135                 140                
 Ala Val Trp Asp Ala Arg Glu Gln Gln Gln Gln Ile Leu Gln Met Ala
 145                 150                 155                 160
 Ile Val Glu His Leu Tyr Gln Gln Gly Met Leu Ser Val Ala Glu Glu
                 165                 170                 175    
 Leu Cys Gln Glu Ser Thr Leu Asn Val Asp Leu Asp Phe Lys Gln Pro
             180                 185                 190        
 Phe Leu Glu Leu Asn Arg Ile Leu Glu Ala Leu His Glu Gln Asp Leu
         195                 200                 205            
 Gly Pro Ala Leu Glu Trp Ala Val Ser His Arg Gln Arg Leu Leu Glu
     210                 215                 220                
 Leu Asn Ser Ser Leu Glu Phe Lys Leu His Arg Leu His Phe Ile Arg
 225                 230                 235                 240
 Leu Leu Ala Gly Gly Pro Ala Lys Gln Leu Glu Ala Leu Ser Tyr Ala
                 245                 250                 255    
 Arg His Phe Gln Pro Phe Ala Arg Leu His Gln Arg Glu Ile Gln Val
             260                 265                 270        
 Met Met Gly Ser Leu Val Tyr Leu Arg Leu Gly Leu Glu Lys Ser Pro
         275                 280                 285            
 Tyr Cys His Leu Leu Asp Ser Ser His Trp Ala Glu Ile Cys Glu Thr
     290                 295                 300                
 Phe Thr Arg Asp Ala Cys Ser Leu Leu Gly Leu Ser Val Glu Ser Pro
 305                 310                 315                 320
 Leu Ser Val Ser Phe Ala Ser Gly Cys Val Ala Leu Pro Val Leu Met
                 325                 330                 335    
 Asn Ile Lys Ala Val Ile Glu Gln Arg Gln Cys Thr Gly Val Trp Asn
             340                 345                 350        
 His Lys Asp Glu Leu Pro Ile Glu Ile Glu Leu Gly Met Lys Cys Trp
         355                 360                 365            
 Tyr His Ser Val Phe Ala Cys Pro Ile Leu Tyr
     370                 375                



      <210> 616
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 616
 Val Gly Pro Lys Phe Glu Pro Asp Arg Ser Ala Gly Arg Arg Leu Ala
   1               5                  10                  15    
 Val Val Phe Arg Gly Asn Thr Pro Ser Leu Trp Leu Ser Met Ser Ile
              20                  25                  30        
 Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln Ile Gly Phe Glu Val
          35                  40                  45            
 Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser Gln Gly Leu Cys Ser
      50                  55                  60                
 Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys Lys Glu Arg Phe Phe
  65                  70                  75                  80
 Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg Ala Val Leu Val Asp
                  85                  90                  95    
 Met Glu Pro Lys Val Ile Asn Gln Thr Leu Ser Lys Ala Ala Gln Ser
             100                 105                 110        
 Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe Cys Gln Lys Gln Gly
         115                 120                 125            
 Ser Gly Asn Asn Trp Ala Tyr Gly
     130                 135    



      <210> 617
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 617
 Val Gly Pro Lys Phe Glu Pro Asp Arg Ser Ala Gly Arg Arg Leu Ala
   1               5                  10                  15    
 Val Val Phe Arg Gly Asn Thr Pro Ser Leu Trp Leu Ser Met Ser Ile
              20                  25                  30        
 Val Thr Val Gln Leu Gly Gln Cys Gly Asn Gln Ile Gly Phe Glu Val
          35                  40                  45            
 Phe Asp Ala Leu Leu Ser Asp Ser His Ser Ser Gln Gly Leu Cys Ser
      50                  55                  60                
 Met Arg Glu Asn Glu Ala Tyr Gln Ala Ser Cys Lys Glu Arg Phe Phe
  65                  70                  75                  80
 Ser Glu Glu Glu Asn Gly Val Pro Ile Ala Arg Ala Val Leu Val Asp
                  85                  90                  95    
 Met Glu Pro Lys Val Ile Asn Gln Thr Leu Ser Lys Ala Ala Gln Ser
             100                 105                 110        
 Gly Gln Trp Lys Tyr Gly Gln His Ala Cys Phe Cys Gln Lys Gln Gly
         115                 120                 125            
 Ser Gly Asn Asn Trp Ala Tyr Gly
     130                 135    



      <210> 618
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 618
 Cys Thr Trp Asn Glu Asn Gln Arg Met Glu Ile Val Trp Glu Val Leu
   1               5                  10                  15    
 Phe Leu Leu Gln Ala Asn Phe Ile Val Cys Ile Ser Ala Gln Gln Asn
              20                  25                  30        
 Ser Pro Lys Ile His Glu Gly Trp Trp Ala Tyr Lys Glu Val Val Gln
          35                  40                  45            
 Gly Ser Phe Val Pro Val Pro Ser Phe Trp Gly Leu Val Asn Ser Ala
      50                  55                  60                
 Trp Asn Leu Cys Ser Val Gly Lys
  65                  70        



      <210> 619
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 619
 Leu Asn Tyr His Gln Asn Ile Asn Asp Phe Phe Glu Thr Glu Ser His
   1               5                  10                  15    
 Ser Val Thr Arg Leu Glu Cys Ser Gly Thr Ile Leu Ala Gln Cys Asn
              20                  25                  30        
 Leu Cys Leu Leu Ser Pro Ser Asp Ser Pro Pro
          35                  40            



      <210> 620
      <211> 188
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(186)
      <223> Xaa = any amino acid or nothing 


      <400> 620
 Arg His Ile Val Ile Gly Glu Gly Lys Leu Lys Gly Gln Pro Gly Ala
   1               5                  10                  15    
 Ser Val Ala Ala Pro Cys Val Arg Leu Val Pro His Ser Ile Pro Val
              20                  25                  30        
 Leu Ala Leu Ser Pro Gly Leu Leu Cys Ser Ala Arg Ser Thr Lys Gln
          35                  40                  45            
 Lys Asn Ser Cys Gln Gln Leu Lys Glu Asp Val Asp Gln Thr Lys Trp
      50                  55                  60                
 Gly Thr Asp Thr Pro Ser Met Asp Xaa Ile Leu Met Glu Glu Val Lys
  65                  70                  75                  80
 Leu Glu Glu Gln Leu Lys Glu Val Val Glu Glu Tyr Lys Leu Ala Leu
                  85                  90                  95    
 Ser Asp Thr Glu Gly Leu Gln Gln Ser Ile Gln Lys Leu Val Asp Glu
             100                 105                 110        
 Ala Asn Met Cys Ser Ile Gln Gly Phe Cys Met Asp Ser Leu Glu Val
         115                 120                 125            
 Ala Asp Val Leu Glu Asn Gly Thr Gln Cys Val Ser Xaa Gln Lys Asn
     130                 135                 140                
 Ser Cys Gln Gln Leu Lys Glu Asp Val Asp Pro Asn Gln Met Gly Asp
 145                 150                 155                 160
 Arg Tyr Ser Leu Tyr Gly Leu Asp Thr His Gly Arg Ser Gln Val Arg
                 165                 170                 175    
 Arg Ala Thr Glu Gly Gly Cys Gly Arg Ile
             180                 185    



      <210> 621
      <211> 97
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(96)
      <223> Xaa = any amino acid or nothing 


      <400> 621
 Arg Lys Gly Gln Gln Gln Thr Cys Leu Ser Leu Arg Val Ser Trp Leu
   1               5                  10                  15    
 Tyr Arg Lys Val Thr Phe Ser Ile Phe Phe Phe Phe Leu Ile Leu Xaa
              20                  25                  30        
 Lys Xaa Arg Trp Gly Leu Thr Met Val Thr Gln Ala Gly Leu Lys Leu
          35                  40                  45            
 Leu Gly Thr Ser Asn Pro Pro Ala Phe Ala Leu Pro Lys Cys Trp Asp
      50                  55                  60                
 Tyr Arg Cys Lys Ser Leu Pro Pro Ala Gln Lys Leu Thr Phe Ser Lys
  65                  70                  75                  80
 Ala Thr Thr Lys Lys Thr Pro Gln Ile Cys Gln Ser Met Lys Val Ser
                  85                  90                  95    





      <210> 622
      <211> 274
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(271)
      <223> Xaa = any amino acid or nothing 


      <400> 622
 His Glu Thr Met Glu Ala Ala Pro Ser Arg Phe Met Phe Leu Leu Phe
   1               5                  10                  15    
 Leu Leu Thr Cys Glu Leu Ala Ala Glu Val Ala Ala Glu Val Glu Lys
              20                  25                  30        
 Ser Ser Asp Gly Pro Gly Ala Ala Gln Glu Pro Thr Trp Leu Thr Asp
          35                  40                  45            
 Val Pro Ala Ala Met Glu Phe Ile Ala Ala Thr Glu Asp Leu Glu Ile
      50                  55                  60                
 Pro Ala Val Pro Ile Leu His Ser Met Val Gln Lys Phe Pro Gly Val
  65                  70                  75                  80
 Ser Phe Gly Ile Ser Thr Asp Ser Glu Val Leu Thr His Tyr Asn Ile
                  85                  90                  95    
 Thr Gly Asn Thr Ile Cys Leu Phe Arg Leu Val Asp Asn Glu Gln Leu
             100                 105                 110        
 Asp Leu Glu Asp Glu Asp Ile Glu Ser Ile Asp Ala Thr Lys Leu Ser
         115                 120                 125            
 Arg Phe Ile Glu Ile Asn Ser Leu His Met Val Thr Glu Tyr Asn Pro
     130                 135                 140                
 Val Thr Val Ile Gly Leu Phe Asn Ser Val Ile Gln Ile His Leu Leu
 145                 150                 155                 160
 Leu Ile Asn Glu Pro Arg Pro Pro Gln Lys Tyr Glu Glu Asn Met His
                 165                 170                 175    
 Arg Tyr Gln Lys Ala Ala Lys Leu Phe Gln Gly Lys Ile Pro Pro Leu
             180                 185                 190        
 Phe Leu Val Gly Gln Leu Asp Glu Arg Lys Met Gly Lys Val Ile Ser
         195                 200                 205            
 Phe Phe Lys Leu Lys Glu Ser Gln Leu Pro Ala Leu Gln Phe Thr Arg
     210                 215                 220                
 Leu Xaa Asp Asp Glu Trp Asp Thr Leu Pro Thr Ala Glu Val Ser Val
 225                 230                 235                 240
 Glu His Val Gln Asn Phe Cys Asp Gly Phe Leu Ser Gly Lys Leu Leu
                 245                 250                 255    
 Lys Glu Asn Arg Glu Ser Glu Gly Lys Thr Pro Lys Val Glu Leu
             260                 265                 270    



      <210> 623
      <211> 93
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(90)
      <223> Xaa = any amino acid or nothing 


      <400> 623
 Asp Arg Val Ser Leu Leu Ser Pro Arg Leu Glu Cys Ser Gly Val Val
   1               5                  10                  15    
 Ser Ala His Cys Lys Leu Arg Leu Pro Gly Ser Arg Arg Phe Ser Cys
              20                  25                  30        
 Leu Ser Leu Ser Gly Ser Trp Asp Tyr Arg Arg Pro Pro Pro Arg Pro
          35                  40                  45            
 Ala Asn Phe Phe Val Phe Leu Val Glu Thr Gly Phe His Cys Gly Leu
      50                  55                  60                
 Asp Leu Leu Thr Ser Xaa Ser Ala Arg Leu Gly Leu Pro Lys Cys Trp
  65                  70                  75                  80
 Asp Tyr Lys Arg Glu Pro Pro His Pro Ala
                  85                  90



      <210> 624
      <211> 718
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(685)
      <223> Xaa = any amino acid or nothing 


      <400> 624
 Asn Ser Ser Trp Pro Ala Glu Pro Ala Ala Ser Pro Trp Arg Pro Leu
   1               5                  10                  15    
 Trp Arg Ala Leu Gly Ala Thr Phe Pro Ser Gly Ser Gln Pro Ala Ala
              20                  25                  30        
 Arg Thr Pro Ala Gly Pro Cys Ile Gly Gly Met Ala Pro Pro Gly Phe
          35                  40                  45            
 Lys His Val Ser Ser Met Leu Ala Leu Thr Ile Ile Ala Ser Thr Trp
      50                  55                  60                
 Ala Leu Thr Pro Thr His Tyr Leu Thr Lys His Asp Val Glu Arg Leu
  65                  70                  75                  80
 Lys Ala Ser Leu Asp Arg Pro Phe Thr Asn Leu Glu Ser Ala Phe Tyr
                  85                  90                  95    
 Ser Ile Val Gly Leu Ser Ser Leu Gly Ala Gln Val Pro Asp Ala Lys
             100                 105                 110        
 Lys Ala Cys Thr Tyr Ile Arg Ser Asn Leu Asp Pro Ser Asn Val Asp
         115                 120                 125            
 Ser Leu Phe Tyr Gly Trp Pro Arg Ala Ser Gln Ala Leu Ser Gly Met
     130                 135                 140                
 Xaa Arg Ser Leu Phe Ser Asn Glu Thr Lys Asp Leu Ala Phe Gly Gln
 145                 150                 155                 160
 Leu Phe Ser Xaa Gly Thr Ser Ser Val Tyr Pro Arg Ser Tyr His Ala
                 165                 170                 175    
 Ser Val Ala Ala Leu Lys Trp Ala Leu Gly Leu Pro Leu Ala Ser Gln
             180                 185                 190        
 Glu Ala Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu Thr Val
         195                 200                 205            
 Leu Ala Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser Gln Gln
     210                 215                 220                
 Ala Asp Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val Ala Arg
 225                 230                 235                 240
 Leu Asp Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly Leu Glu
                 245                 250                 255    
 Thr Thr Ala Leu Phe Val Ala Ala Thr Tyr Lys Ala Leu Met Asp His
             260                 265                 270        
 Val Gly Thr Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu Met
         275                 280                 285            
 Asn Ala Ile Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala Phe
     290                 295                 300                
 Ser Val Ala Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His Val
 305                 310                 315                 320
 Pro Val Val Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu Gln
                 325                 330                 335    
 Ala Ile Leu Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu Thr
             340                 345                 350        
 Gln Ala Thr Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg Ala
         355                 360                 365            
 Thr Val Leu Gln Lys Thr Ser Phe Thr Pro Val Gly Ile Val Phe Glu
     370                 375                 380                
 Leu Asn Phe Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe Leu
 385                 390                 395                 400
 Gly Arg Lys Leu Lys Gly Asp Asn Arg Tyr Ile Ser Asn Thr Val Glu
                 405                 410                 415    
 Leu Arg Val Gln Asp Pro Pro Thr Glu Val Gly Ile Thr Asn Val Asp
             420                 425                 430        
 Leu Ser Thr Val Asp Lys Asp Gln Ser Ile Ala Pro Gln Thr Thr Arg
         435                 440                 445            
 Val Thr Tyr Pro Ala Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His
     450                 455                 460                
 Gln Asn Phe Ala Leu Phe Phe Gln Leu Val Gly Val Asn Thr Gly Ala
 465                 470                 475                 480
 Glu Leu Thr Pro His Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr
                 485                 490                 495    
 Gly Gln Glu Val Val Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr
             500                 505                 510        
 Lys Phe Glu Leu Asp Thr Ser Glu Arg Lys Gly Leu Asn Leu Thr Ser
         515                 520                 525            
 Arg Ser Gly Thr Tyr Thr Phe Tyr Leu Ile Ile Gly Asp Ala Thr Leu
     530                 535                 540                
 Lys Asn Pro Ile Leu Trp Asn Val Ala Asp Val Val Ile Lys Phe Pro
 545                 550                 555                 560
 Glu Glu Glu Ala Pro Ser Thr Val Leu Ser Gln Asn Leu Phe Thr Pro
                 565                 570                 575    
 Lys Gln Glu Ile Gln His Leu Phe Arg Glu Pro Glu Lys Arg Pro Pro
             580                 585                 590        
 Thr Val Val Ser Asn Thr Phe Thr Ala Leu Ile Leu Ser Pro Leu Leu
         595                 600                 605            
 Leu Leu Phe Ala Leu Trp Ile Arg Ile Gly Ala Asn Val Ser Asn Phe
     610                 615                 620                
 Thr Phe Ala Pro Ser Thr Ile Ile Phe His Leu Gly His Ala Ala Met
 625                 630                 635                 640
 Leu Gly Leu Met Tyr Val Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr
                 645                 650                 655    
 Leu Lys Tyr Leu Ala Ile Leu Gly Ser Val Thr Phe Leu Ala Gly Asn
             660                 665                 670        
 Arg Met Leu Ala Gln Gln Ala Val Lys Arg Thr Ala His
         675                 680                 685



      <210> 625
      <211> 146
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(140)
      <223> Xaa = any amino acid or nothing 


      <400> 625
 Gln Gly Ser Lys Val Phe Ile Lys Lys Cys Ser Thr Ser Ser Leu Thr
   1               5                  10                  15    
 Arg Glu Met Gln Ile Ser Thr Gln Arg Ser His Cys Gly Thr Leu Ile
              20                  25                  30        
 Xaa Ala Ser Glu Val Arg Lys Ser Gly Xaa His Gln Cys Gln Arg Xaa
          35                  40                  45            
 Leu Trp Glu Gly Asp Leu Leu His Cys Xaa Xaa Gln Cys Glu Leu Met
      50                  55                  60                
 Glu Pro Thr Trp Lys Met Ala Trp His Gln Leu Leu Glu Lys Lys Thr
  65                  70                  75                  80
 His Ser Pro Leu Asp Leu Pro Val Pro His Gln Gly Leu Asp Met Ala
                  85                  90                  95    
 Val Met Cys Tyr Gln Gly Ala Cys Ala Arg Asn Leu Tyr Ser Gln Ile
             100                 105                 110        
 Leu Thr Ile Ala Pro Asn Trp Asn Gln Pro Thr Tyr Pro Ser Gly Arg
         115                 120                 125            
 Glu Trp Met Leu Lys Asn Ala Arg Ile Ala Ile Gly
     130                 135                 140



      <210> 626
      <211> 318
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(316)
      <223> Xaa = any amino acid or nothing 


      <400> 626
 Ser Val Ser Thr Thr Arg Ser Phe Ser Val Asp Ser Ser Ala Lys Thr
   1               5                  10                  15    
 Ala Ala Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr
              20                  25                  30        
 Thr Ser Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg
          35                  40                  45            
 Ala Leu Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser
      50                  55                  60                
 Thr Cys Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly
  65                  70                  75                  80
 Ser Met Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val
                  85                  90                  95    
 Thr Leu Ile Ile Leu Ile Val Glu Leu Ser Gly Leu Gln Ala Arg Phe
             100                 105                 110        
 Pro Leu Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala
         115                 120                 125            
 Leu Phe Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln
     130                 135                 140                
 Phe Leu Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe
 145                 150                 155                 160
 Phe Ser Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr
                 165                 170                 175    
 Arg Ala Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly
             180                 185                 190        
 Leu Leu Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe
         195                 200                 205            
 Ile Ser Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys
     210                 215                 220                
 Val Ala Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu
 225                 230                 235                 240
 Leu Asn Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser
                 245                 250                 255    
 Phe Leu Ser Gly Leu Ala Phe Cys Leu Ser Ser Ser Met Pro Pro Pro
             260                 265                 270        
 Leu Phe Ser Gly Pro Ser Thr Ser Ser Met Arg Ser Met Ala Ala Ser
         275                 280                 285            
 Leu Gly Ala Arg Glu Met Xaa Ala Ala Ala Ala Ala Met Pro Thr Thr
     290                 295                 300                
 Cys Val Pro Gly Thr Ala Asp Trp Leu Trp Pro Ser
 305                 310                 315    



      <210> 627
      <211> 686
      <212> PRT
      <213> Homo sapiens


      <400> 627
 Gly Cys Gln Arg Phe Met Ile Asn Met Gly Asp Ser His Val Asp Thr
   1               5                  10                  15    
 Ser Ser Thr Val Ser Glu Ala Val Ala Glu Glu Val Ser Leu Phe Ser
              20                  25                  30        
 Met Thr Asp Met Ile Leu Phe Ser Leu Ile Val Gly Leu Leu Thr Tyr
          35                  40                  45            
 Trp Phe Leu Phe Arg Lys Lys Lys Glu Glu Val Pro Glu Phe Thr Lys
      50                  55                  60                
 Ile Gln Thr Leu Thr Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys
  65                  70                  75                  80
 Met Lys Lys Thr Gly Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr
                  85                  90                  95    
 Gly Thr Ala Glu Glu Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg
             100                 105                 110        
 Tyr Gly Met Arg Gly Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala
         115                 120                 125            
 Asp Leu Ser Ser Leu Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys
     130                 135                 140                
 Met Ala Thr Tyr Gly Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe
 145                 150                 155                 160
 Tyr Asp Trp Leu Gln Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe
                 165                 170                 175    
 Ala Val Phe Gly Leu Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met
             180                 185                 190        
 Gly Lys Tyr Val Asp Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile
         195                 200                 205            
 Phe Glu Leu Gly Leu Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe
     210                 215                 220                
 Ile Thr Trp Arg Glu Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly
 225                 230                 235                 240
 Val Glu Ala Thr Gly Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val
                 245                 250                 255    
 Val His Thr Asp Ile Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly
             260                 265                 270        
 Arg Leu Lys Ser Tyr Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn
         275                 280                 285            
 Pro Phe Leu Ala Ala Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr
     290                 295                 300                
 Glu Arg His Leu Met His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile
 305                 310                 315                 320
 Arg Tyr Glu Ser Gly Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser
                 325                 330                 335    
 Ala Leu Val Asn Gln Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val
             340                 345                 350        
 Val Met Ser Leu Asn Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro
         355                 360                 365            
 Phe Pro Cys Pro Thr Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp
     370                 375                 380                
 Ile Thr Asn Pro Pro Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr
 385                 390                 395                 400
 Ala Ser Glu Pro Ser Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser
                 405                 410                 415    
 Ser Gly Glu Gly Lys Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg
             420                 425                 430        
 Arg His Ile Leu Ala Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro
         435                 440                 445            
 Ile Asp His Leu Cys Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr
     450                 455                 460                
 Ser Ile Ala Ser Ser Ser Lys Val His Pro Asn Ser Val His Ile Cys
 465                 470                 475                 480
 Ala Val Val Val Glu Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly
                 485                 490                 495    
 Val Ala Thr Asn Trp Leu Arg Ala Lys Glu Pro Val Gly Glu Asn Gly
             500                 505                 510        
 Gly Arg Ala Leu Val Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu
         515                 520                 525            
 Pro Phe Lys Ala Thr Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly
     530                 535                 540                
 Val Ala Pro Phe Ile Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln
 545                 550                 555                 560
 Gln Gly Lys Glu Val Gly Glu Thr Leu Leu Tyr Tyr Gly Cys Arg Arg
                 565                 570                 575    
 Ser Asp Glu Asp Tyr Leu Tyr Arg Glu Glu Leu Ala Gln Phe His Arg
             580                 585                 590        
 Asp Gly Ala Leu Thr Gln Leu Asn Val Ala Phe Ser Arg Glu Gln Ser
         595                 600                 605            
 His Lys Val Tyr Val Gln His Leu Leu Lys Gln Asp Arg Glu His Leu
     610                 615                 620                
 Trp Lys Leu Ile Glu Gly Gly Ala His Ile Tyr Val Cys Gly Asp Ala
 625                 630                 635                 640
 Arg Asn Met Ala Arg Asp Val Gln Asn Thr Phe Tyr Asp Ile Val Ala
                 645                 650                 655    
 Glu Leu Gly Ala Met Glu His Ala Gln Ala Val Asp Tyr Ile Lys Lys
             660                 665                 670        
 Leu Met Thr Lys Gly Arg Tyr Ser Leu Asp Val Trp Ser
         675                 680                 685



      <210> 628
      <211> 590
      <212> PRT
      <213> Homo sapiens


      <400> 628
 Met Ser Arg Arg Leu Leu Pro Arg Ala Glu Lys Arg Arg Arg Arg Leu
   1               5                  10                  15    
 Glu Gln Arg Gln Gln Pro Asp Glu Gln Arg Arg Arg Ser Gly Ala Met
              20                  25                  30        
 Val Lys Met Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Arg Tyr Tyr
          35                  40                  45            
 Gly Gly Gly Ser Glu Gly Gly Arg Ala Pro Lys Arg Leu Lys Thr Asp
      50                  55                  60                
 Asn Ala Gly Asp Gln His Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala
  65                  70                  75                  80
 Gly Ala Ala Gly Gly Gly Gly Gly Gly Glu Asn Tyr Asp Asp Pro His
                  85                  90                  95    
 Lys Thr Pro Ala Ser Pro Val Val His Ile Arg Gly Leu Ile Asp Gly
             100                 105                 110        
 Val Val Glu Ala Asp Leu Val Glu Ala Leu Gln Glu Phe Gly Pro Ile
         115                 120                 125            
 Ser Tyr Val Val Val Met Pro Lys Lys Arg Gln Ala Leu Val Glu Phe
     130                 135                 140                
 Glu Asp Val Leu Gly Ala Cys Asn Ala Val Asn Tyr Ala Ala Asp Asn
 145                 150                 155                 160
 Gln Ile Tyr Ile Ala Gly His Pro Ala Phe Val Asn Tyr Ser Thr Ser
                 165                 170                 175    
 Gln Lys Ile Ser Arg Pro Gly Asp Ser Asp Asp Ser Arg Ser Val Asn
             180                 185                 190        
 Ser Val Leu Leu Phe Thr Ile Leu Asn Pro Ile Tyr Ser Ile Thr Thr
         195                 200                 205            
 Asp Val Leu Tyr Thr Ile Cys Asn Pro Cys Gly Pro Val Gln Arg Ile
     210                 215                 220                
 Val Ile Phe Arg Lys Asn Gly Val Gln Ala Met Val Glu Phe Asp Ser
 225                 230                 235                 240
 Val Gln Ser Ala Gln Arg Ala Lys Ala Ser Leu Asn Gly Ala Asp Ile
                 245                 250                 255    
 Tyr Ser Gly Cys Cys Thr Leu Lys Ile Glu Tyr Ala Lys Pro Thr Arg
             260                 265                 270        
 Leu Asn Val Phe Lys Asn Asp Gln Asp Thr Trp Asp Tyr Thr Asn Pro
         275                 280                 285            
 Asn Leu Ser Gly Gln Gly Asp Pro Gly Ser Asn Pro Asn Lys Arg Gln
     290                 295                 300                
 Arg Gln Pro Pro Leu Leu Gly Asp His Pro Ala Glu Tyr Gly Gly Pro
 305                 310                 315                 320
 His Gly Gly Tyr His Ser His Tyr His Asp Glu Gly Tyr Gly Pro Pro
                 325                 330                 335    
 Pro Pro His Tyr Glu Gly Arg Arg Met Gly Pro Pro Val Gly Gly His
             340                 345                 350        
 Arg Arg Gly Pro Ser Arg Tyr Gly Pro Gln Tyr Gly His Pro Pro Pro
         355                 360                 365            
 Pro Pro Pro Pro Pro Glu Tyr Gly Pro His Ala Asp Ser Pro Val Leu
     370                 375                 380                
 Met Val Tyr Gly Leu Asp Gln Ser Lys Met Asn Cys Asp Arg Val Phe
 385                 390                 395                 400
 Asn Val Phe Cys Leu Tyr Gly Asn Val Glu Lys Val Lys Phe Met Lys
                 405                 410                 415    
 Ser Lys Pro Gly Ala Ala Met Val Glu Met Ala Asp Gly Tyr Ala Val
             420                 425                 430        
 Asp Arg Ala Ile Thr His Leu Asn Asn Asn Phe Met Phe Gly Gln Lys
         435                 440                 445            
 Leu Asn Val Cys Val Ser Lys Gln Pro Ala Ile Met Pro Gly Gln Ser
     450                 455                 460                
 Tyr Gly Leu Glu Asp Gly Ser Cys Ser Tyr Lys Asp Phe Ser Glu Ser
 465                 470                 475                 480
 Arg Asn Asn Arg Phe Ser Thr Pro Glu Gln Ala Ala Lys Asn Arg Ile
                 485                 490                 495    
 Gln His Pro Ser Asn Val Leu His Phe Phe Asn Ala Pro Leu Glu Val
             500                 505                 510        
 Thr Glu Glu Asn Phe Phe Glu Ile Cys Asp Glu Leu Gly Val Lys Arg
         515                 520                 525            
 Pro Ser Ser Val Lys Val Phe Ser Gly Lys Ser Glu Arg Ser Ser Ser
     530                 535                 540                
 Gly Leu Leu Glu Trp Glu Ser Lys Ser Asp Ala Leu Glu Thr Leu Gly
 545                 550                 555                 560
 Phe Leu Asn His Tyr Gln Met Lys Asn Pro Asn Gly Pro Tyr Pro Tyr
                 565                 570                 575    
 Thr Leu Lys Leu Cys Phe Ser Thr Ala Gln His Ala Ser
             580                 585                



      <210> 629
      <211> 615
      <212> PRT
      <213> Homo sapiens


      <400> 629
 Ser Asn Leu Pro Glu Ala Asn Val Met Ser Ile Val Ile Pro Leu Gly
   1               5                  10                  15    
 Val Asp Thr Ala Glu Thr Ser Tyr Leu Glu Met Ala Ala Gly Ser Glu
              20                  25                  30        
 Pro Glu Ser Val Glu Ala Ser Pro Val Val Val Glu Lys Ser Asn Ser
          35                  40                  45            
 Tyr Pro His Gln Leu Tyr Thr Ser Ser Ser His His Ser His Ser Tyr
      50                  55                  60                
 Asn Gly Phe Ala Pro Met Arg Thr His Asn Arg Val Leu Val Pro Pro
  65                  70                  75                  80
 Pro Asn Thr Pro Ala Pro Pro Pro Pro Ser Val Leu Ile Ser Lys Asn
                  85                  90                  95    
 Glu Val Gly His Ile Tyr Pro Leu Pro Asn Phe Asp Glu Thr Ser Gln
             100                 105                 110        
 Cys Leu Pro Thr Ile Ser Thr Ser Glu Asp Gly Ser Tyr Gly Thr Asp
         115                 120                 125            
 Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp Asp Gly Tyr Met Ile
     130                 135                 140                
 Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile Asp Cys Met Gly Ile
 145                 150                 155                 160
 Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys Glu Arg Cys Gln Pro
                 165                 170                 175    
 Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu Gln Arg Arg Lys Arg
             180                 185                 190        
 Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr Glu Ser Gly Asp Glu
         195                 200                 205            
 Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His Thr Pro Thr Ser Ile
     210                 215                 220                
 Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn Asp Lys Arg Arg Lys
 225                 230                 235                 240
 Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys Cys Lys Lys Gly Ser
                 245                 250                 255    
 Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly Trp Glu
             260                 265                 270        
 Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn Asn Asn
         275                 280                 285            
 Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala Leu Arg
     290                 295                 300                
 Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp Leu Asn
 305                 310                 315                 320
 Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile Gln Lys
                 325                 330                 335    
 Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Trp Pro Pro Asp Ala Leu
             340                 345                 350        
 Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe Glu Ala
         355                 360                 365            
 Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe Tyr Ser
     370                 375                 380                
 Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe Gly Asn
 385                 390                 395                 400
 Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu Val Arg
                 405                 410                 415    
 His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser Ile His
             420                 425                 430        
 Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe Asp Tyr
         435                 440                 445            
 Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu Asn Pro
     450                 455                 460                
 Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn Ile Asn
 465                 470                 475                 480
 Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys Asp Ile
                 485                 490                 495    
 Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp Cys Glu
             500                 505                 510        
 Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg Lys Leu
         515                 520                 525            
 Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp Phe Ile
     530                 535                 540                
 Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu Met Glu
 545                 550                 555                 560
 Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Asn Trp Thr Val
                 565                 570                 575    
 Asp Gly Cys Gly Ser Trp Phe Trp Phe Arg Ala Glu Ala Ser Val Lys
             580                 585                 590        
 Ala Leu Gly Leu Thr Leu Asn Val Leu Phe Gly
         595                 600            



      <210> 630
      <211> 615
      <212> PRT
      <213> Homo sapiens


      <400> 630
 Ser Asn Leu Pro Glu Ala Asn Val Met Ser Ile Val Ile Pro Leu Gly
   1               5                  10                  15    
 Val Asp Thr Ala Glu Thr Ser Tyr Leu Glu Met Ala Ala Gly Ser Glu
              20                  25                  30        
 Pro Glu Ser Val Glu Ala Ser Pro Val Val Val Glu Lys Ser Asn Ser
          35                  40                  45            
 Tyr Pro His Gln Leu Tyr Thr Ser Ser Ser His His Ser His Ser Tyr
      50                  55                  60                
 Asn Gly Phe Ala Pro Met Arg Thr His Asn Arg Val Leu Val Pro Pro
  65                  70                  75                  80
 Pro Asn Thr Pro Ala Pro Pro Pro Pro Ser Val Leu Ile Ser Lys Asn
                  85                  90                  95    
 Glu Val Gly His Ile Tyr Pro Leu Pro Asn Phe Asp Glu Thr Ser Gln
             100                 105                 110        
 Cys Leu Pro Thr Ile Ser Thr Ser Glu Asp Gly Ser Tyr Gly Thr Asp
         115                 120                 125            
 Val Thr Arg Cys Ile Cys Gly Phe Thr His Asp Asp Gly Tyr Met Ile
     130                 135                 140                
 Cys Cys Asp Lys Cys Ser Val Trp Gln His Ile Asp Cys Met Gly Ile
 145                 150                 155                 160
 Asp Arg Gln His Ile Pro Asp Thr Tyr Leu Cys Glu Arg Cys Gln Pro
                 165                 170                 175    
 Arg Asn Leu Asp Lys Glu Arg Ala Val Leu Leu Gln Arg Arg Lys Arg
             180                 185                 190        
 Glu Asn Met Ser Asp Gly Asp Thr Ser Ala Thr Glu Ser Gly Asp Glu
         195                 200                 205            
 Val Pro Val Glu Leu Tyr Thr Ala Phe Gln His Thr Pro Thr Ser Ile
     210                 215                 220                
 Thr Leu Thr Ala Ser Arg Val Ser Lys Val Asn Asp Lys Arg Arg Lys
 225                 230                 235                 240
 Lys Ser Gly Glu Lys Glu Gln His Ile Ser Lys Cys Lys Lys Gly Ser
                 245                 250                 255    
 Ala Pro Glu Ile Asp Pro Ser Ser Asp Gly Ser Asn Phe Gly Trp Glu
             260                 265                 270        
 Thr Lys Ile Lys Ala Trp Met Asp Arg Tyr Glu Glu Ala Asn Asn Asn
         275                 280                 285            
 Gln Tyr Ser Glu Gly Val Gln Arg Glu Ala Gln Arg Ile Ala Leu Arg
     290                 295                 300                
 Leu Gly Asn Gly Asn Asp Lys Lys Glu Met Asn Lys Ser Asp Leu Asn
 305                 310                 315                 320
 Thr Asn Asn Leu Leu Phe Lys Pro Pro Val Glu Ser His Ile Gln Lys
                 325                 330                 335    
 Asn Lys Lys Ile Leu Lys Ser Ala Lys Asp Trp Pro Pro Asp Ala Leu
             340                 345                 350        
 Ile Ile Glu Tyr Arg Gly Lys Phe Met Leu Arg Glu Gln Phe Glu Ala
         355                 360                 365            
 Asn Gly Tyr Phe Phe Lys Arg Pro Tyr Pro Phe Val Leu Phe Tyr Ser
     370                 375                 380                
 Lys Phe His Gly Leu Glu Met Cys Val Asp Ala Arg Thr Phe Gly Asn
 385                 390                 395                 400
 Glu Ala Arg Phe Ile Arg Arg Ser Cys Thr Pro Asn Ala Glu Val Arg
                 405                 410                 415    
 His Glu Ile Gln Asp Gly Thr Ile His Leu Tyr Ile Tyr Ser Ile His
             420                 425                 430        
 Ser Ile Pro Lys Gly Thr Glu Ile Thr Ile Ala Phe Asp Phe Asp Tyr
         435                 440                 445            
 Gly Asn Cys Lys Tyr Lys Val Asp Cys Ala Cys Leu Lys Glu Asn Pro
     450                 455                 460                
 Glu Cys Pro Val Leu Lys Arg Ser Ser Glu Ser Met Glu Asn Ile Asn
 465                 470                 475                 480
 Ser Gly Tyr Glu Thr Arg Arg Lys Lys Gly Lys Lys Asp Lys Asp Ile
                 485                 490                 495    
 Ser Lys Glu Lys Asp Thr Gln Asn Gln Asn Ile Thr Leu Asp Cys Glu
             500                 505                 510        
 Gly Thr Thr Asn Lys Met Lys Ser Pro Glu Thr Lys Gln Arg Lys Leu
         515                 520                 525            
 Ser Pro Leu Arg Leu Ser Val Ser Asn Asn Gln Glu Pro Asp Phe Ile
     530                 535                 540                
 Asp Asp Ile Glu Glu Lys Thr Pro Ile Ser Asn Glu Val Glu Met Glu
 545                 550                 555                 560
 Ser Glu Glu Gln Ile Ala Glu Arg Lys Arg Lys Met Asn Trp Thr Val
                 565                 570                 575    
 Asp Gly Cys Gly Ser Trp Phe Trp Phe Arg Ala Glu Ala Ser Val Lys
             580                 585                 590        
 Ala Leu Gly Leu Thr Leu Asn Val Leu Phe Gly
         595                 600            



      <210> 631
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 631
 Leu Gly His Cys Asn Leu Ser Ile Tyr Ser Tyr Glu Ile Lys Thr Gly
   1               5                  10                  15    
 Val Pro Ser Pro Arg Gly Met Ile Tyr Leu Leu Leu Cys Val Cys Val
              20                  25                  30        
 Cys Val Cys Leu Pro Asn His Ala Ile Ile Val Met Leu Asn Arg Thr
          35                  40                  45            
 Glu Pro Tyr Val Pro Glu Gly Gly Ala Tyr Leu Pro Glu Arg Glu Pro
      50                  55                  60                
 Phe Ile Val Pro Val Glu Pro Glu Arg Thr Ala Glu Tyr Glu Asp Tyr
  65                  70                  75                  80
 Gly Ala Asp Glu Pro Ala Glu Glu Pro Pro Glu Pro His Arg Arg Trp
                  85                  90                  95    
 Arg Arg Ala Leu Pro His Gly Pro Gly Gln
             100                 105    



      <210> 632
      <211> 84
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(84)
      <223> Xaa = any amino acid or nothing 


      <400> 632
 Gln Ile Glu Ser Ser Ser Leu Asn Val Asn Lys Lys Asp Asn His Thr
   1               5                  10                  15    
 Lys Thr Pro Ser Glu Gly His Gln His Gln Arg Pro Lys Val Asp Lys
              20                  25                  30        
 Ser Leu Lys Met Arg Lys Lys Gln Arg Lys Lys Ala Glu Asn Ser Lys
          35                  40                  45            
 Asn Gln Asn Ala Ser Ser Pro Pro Lys Glu His Asn Ser Ser Pro Ala
      50                  55                  60                
 Lys Glu Gln Asn Xaa Thr Glu Asn Glu Phe Asp Glu Leu Thr Glu Val
  65                  70                  75                  80
 Gly Phe Arg Met
                



      <210> 633
      <211> 37
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(37)
      <223> Xaa = any amino acid or nothing 


      <400> 633
 Met Glu Ser Cys Ser Val Thr Gln Val Gly Val Gln Trp His Asn Gln
   1               5                  10                  15    
 Leu Thr Ala Thr Pro Pro Pro Arg Phe Lys Arg Leu Ser Ser Xaa Asp
              20                  25                  30        
 Tyr Arg Ala Cys Ile
          35        



      <210> 634
      <211> 80
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(80)
      <223> Xaa = any amino acid or nothing 


      <400> 634
 Arg His Lys Lys Arg Cys Leu Thr Tyr Leu Thr Ile Lys Xaa Met Gln
   1               5                  10                  15    
 Ile Lys Thr Lys Met Arg Tyr His Phe Thr His Ser Arg Met Phe Ile
              20                  25                  30        
 Val Lys Lys Asp Ser Lys Cys Trp Gln Ile Cys Gly Glu Ile Glu Ile
          35                  40                  45            
 Leu Thr His Cys Trp Trp Lys Cys Thr Met Val Gln Ser Leu Trp Lys
      50                  55                  60                
 Ile Val Xaa Pro Phe Leu Lys Met Met Glu Lys Met Arg Ser Glu Phe
  65                  70                  75                  80





      <210> 635
      <211> 132
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(132)
      <223> Xaa = any amino acid or nothing 


      <400> 635
 Ala Gln Gly Pro Tyr Leu Ala Arg His Glu Pro Leu Thr Ala Ser Ser
   1               5                  10                  15    
 Leu Ser Arg Ser Ala Met Ser Ser Glu Pro Pro Pro Pro Pro Gln Pro
              20                  25                  30        
 Pro Thr His Gln Ala Ser Val Gly Leu Leu Asp Thr Pro Trp Ser Arg
          35                  40                  45            
 Glu Arg Ser Pro Ser Pro Leu Arg Gly Asn Val Val Pro Ser Pro Leu
      50                  55                  60                
 Pro Thr Arg Arg Thr Arg Thr Phe Ser Ala Xaa Val Thr Gly Ser Ser
  65                  70                  75                  80
 Gly Leu Gly Ser Thr Leu Asn Leu Gln Gly Ala Phe Leu Val Ser His
                  85                  90                  95    
 Pro Gln Pro Thr Ala Gln Pro Gln Val Cys Leu Phe Gly Ser Pro Gly
             100                 105                 110        
 His Arg Pro Lys Asn Gly Gln Arg His Ser Glu Ser Leu Ala Ser Gly
         115                 120                 125            
 Lys Arg Ser Ile
     130        



      <210> 636
      <211> 566
      <212> PRT
      <213> Homo sapiens


      <400> 636
 Phe Pro Ala Arg Pro Thr Arg Pro Arg Thr Arg Gly Gly Val Val Val
   1               5                  10                  15    
 Gly Ala Ala Ala Ala Gly Pro Arg Cys Gly Ser Ala Arg Ala Gln Val
              20                  25                  30        
 Ala Glu Gly Ala Val Arg Asn Ile Gln Ala Glu Gly His Arg Gln Ile
          35                  40                  45            
 Pro Asp Leu Thr Trp Thr Thr Leu Leu Leu Leu Ala Arg Pro Phe Asn
      50                  55                  60                
 Ser Pro Pro Leu Arg Ser Gly Leu Ala Pro Pro Pro Asp Leu Ser Leu
  65                  70                  75                  80
 Val Leu Leu Gln Ala Leu Thr Leu Asp Leu Arg Trp Leu Pro His Leu
                  85                  90                  95    
 Ser Gly Ala Met Ala Thr Gly Ala Asp Val Arg Asp Ile Leu Glu Leu
             100                 105                 110        
 Gly Gly Pro Glu Gly Asp Ala Ala Ser Gly Thr Ile Ser Lys Lys Asp
         115                 120                 125            
 Ile Ile Asn Pro Asp Lys Lys Lys Ser Lys Lys Ser Ser Glu Thr Leu
     130                 135                 140                
 Thr Phe Lys Arg Pro Glu Gly Met His Arg Glu Val Tyr Ala Leu Leu
 145                 150                 155                 160
 Tyr Ser Asp Lys Lys Asp Ala Pro Pro Leu Leu Pro Ser Asp Thr Gly
                 165                 170                 175    
 Gln Gly Tyr Arg Thr Val Lys Ala Lys Leu Gly Ser Lys Lys Val Arg
             180                 185                 190        
 Pro Trp Lys Trp Met Pro Phe Thr Asn Pro Ala Arg Lys Asp Gly Ala
         195                 200                 205            
 Met Phe Phe His Trp Arg Arg Ala Ala Glu Glu Gly Lys Asp Tyr Pro
     210                 215                 220                
 Phe Ala Arg Phe Asn Lys Thr Val Gln Val Pro Val Tyr Ser Glu Gln
 225                 230                 235                 240
 Glu Tyr Gln Leu Tyr Leu His Asp Asp Ala Trp Thr Lys Ala Glu Thr
                 245                 250                 255    
 Asp His Leu Phe Asp Leu Ser Arg Arg Phe Asp Leu Arg Phe Val Val
             260                 265                 270        
 Ile His Asp Arg Tyr Asp His Gln Gln Phe Lys Lys Arg Ser Val Glu
         275                 280                 285            
 Asp Leu Lys Glu Arg Tyr Tyr His Ile Cys Ala Lys Leu Ala Asn Val
     290                 295                 300                
 Arg Ala Val Pro Gly Thr Asp Leu Lys Ile Pro Val Phe Asp Ala Gly
 305                 310                 315                 320
 His Glu Arg Arg Arg Lys Glu Gln Leu Glu Arg Leu Tyr Asn Arg Thr
                 325                 330                 335    
 Pro Glu Gln Val Ala Glu Glu Glu Tyr Leu Leu Gln Glu Leu Arg Lys
             340                 345                 350        
 Ile Glu Ala Arg Lys Lys Glu Arg Glu Lys Arg Ser Gln Asp Leu Gln
         355                 360                 365            
 Lys Leu Ile Thr Ala Ala Asp Thr Thr Ala Glu Gln Arg Arg Thr Glu
     370                 375                 380                
 Arg Lys Ala Pro Lys Lys Lys Leu Pro Gln Lys Lys Glu Ala Glu Lys
 385                 390                 395                 400
 Pro Ala Val Pro Glu Thr Ala Gly Ile Lys Phe Pro Asp Phe Lys Ser
                 405                 410                 415    
 Ala Gly Val Thr Leu Arg Ser Gln Arg Met Lys Leu Pro Ser Ser Val
             420                 425                 430        
 Gly Gln Lys Lys Ile Lys Ala Leu Glu Gln Met Leu Leu Glu Leu Gly
         435                 440                 445            
 Val Glu Leu Ser Pro Thr Pro Thr Glu Glu Leu Val His Met Phe Asn
     450                 455                 460                
 Glu Leu Arg Ser Asp Leu Val Leu Leu Tyr Glu Leu Lys Gln Ala Cys
 465                 470                 475                 480
 Ala Asn Cys Glu Tyr Glu Leu Gln Met Leu Arg His Arg His Glu Ala
                 485                 490                 495    
 Leu Ala Arg Ala Gly Val Leu Gly Gly Pro Ala Thr Pro Ala Ser Gly
             500                 505                 510        
 Pro Gly Pro Ala Ser Ala Glu Pro Ala Val Thr Glu Pro Gly Leu Gly
         515                 520                 525            
 Pro Asp Pro Lys Asp Thr Ile Ile Asp Val Val Gly Ala Pro Leu Thr
     530                 535                 540                
 Pro Asn Ser Arg Lys Arg Arg Glu Ser Ala Ser Ser Ser Ser Ser Val
 545                 550                 555                 560
 Lys Lys Ala Lys Lys Pro
                 565    



      <210> 637
      <211> 566
      <212> PRT
      <213> Homo sapiens


      <400> 637
 Phe Pro Ala Arg Pro Thr Arg Pro Arg Thr Arg Gly Gly Val Val Val
   1               5                  10                  15    
 Gly Ala Ala Ala Ala Gly Pro Arg Cys Gly Ser Ala Arg Ala Gln Val
              20                  25                  30        
 Ala Glu Gly Ala Val Arg Asn Ile Gln Ala Glu Gly His Arg Gln Ile
          35                  40                  45            
 Pro Asp Leu Thr Trp Thr Thr Leu Leu Leu Leu Ala Arg Pro Phe Asn
      50                  55                  60                
 Ser Pro Pro Leu Arg Ser Gly Leu Ala Pro Pro Pro Asp Leu Ser Leu
  65                  70                  75                  80
 Val Leu Leu Gln Ala Leu Thr Leu Asp Leu Arg Trp Leu Pro His Leu
                  85                  90                  95    
 Ser Gly Ala Met Ala Thr Gly Ala Asp Val Arg Asp Ile Leu Glu Leu
             100                 105                 110        
 Gly Gly Pro Glu Gly Asp Ala Ala Ser Gly Thr Ile Ser Lys Lys Asp
         115                 120                 125            
 Ile Ile Asn Pro Asp Lys Lys Lys Ser Lys Lys Ser Ser Glu Thr Leu
     130                 135                 140                
 Thr Phe Lys Arg Pro Glu Gly Met His Arg Glu Val Tyr Ala Leu Leu
 145                 150                 155                 160
 Tyr Ser Asp Lys Lys Asp Ala Pro Pro Leu Leu Pro Ser Asp Thr Gly
                 165                 170                 175    
 Gln Gly Tyr Arg Thr Val Lys Ala Lys Leu Gly Ser Lys Lys Val Arg
             180                 185                 190        
 Pro Trp Lys Trp Met Pro Phe Thr Asn Pro Ala Arg Lys Asp Gly Ala
         195                 200                 205            
 Met Phe Phe His Trp Arg Arg Ala Ala Glu Glu Gly Lys Asp Tyr Pro
     210                 215                 220                
 Phe Ala Arg Phe Asn Lys Thr Val Gln Val Pro Val Tyr Ser Glu Gln
 225                 230                 235                 240
 Glu Tyr Gln Leu Tyr Leu His Asp Asp Ala Trp Thr Lys Ala Glu Thr
                 245                 250                 255    
 Asp His Leu Phe Asp Leu Ser Arg Arg Phe Asp Leu Arg Phe Val Val
             260                 265                 270        
 Ile His Asp Arg Tyr Asp His Gln Gln Phe Lys Lys Arg Ser Val Glu
         275                 280                 285            
 Asp Leu Lys Glu Arg Tyr Tyr His Ile Cys Ala Lys Leu Ala Asn Val
     290                 295                 300                
 Arg Ala Val Pro Gly Thr Asp Leu Lys Ile Pro Val Phe Asp Ala Gly
 305                 310                 315                 320
 His Glu Arg Arg Arg Lys Glu Gln Leu Glu Arg Leu Tyr Asn Arg Thr
                 325                 330                 335    
 Pro Glu Gln Val Ala Glu Glu Glu Tyr Leu Leu Gln Glu Leu Arg Lys
             340                 345                 350        
 Ile Glu Ala Arg Lys Lys Glu Arg Glu Lys Arg Ser Gln Asp Leu Gln
         355                 360                 365            
 Lys Leu Ile Thr Ala Ala Asp Thr Thr Ala Glu Gln Arg Arg Thr Glu
     370                 375                 380                
 Arg Lys Ala Pro Lys Lys Lys Leu Pro Gln Lys Lys Glu Ala Glu Lys
 385                 390                 395                 400
 Pro Ala Val Pro Glu Thr Ala Gly Ile Lys Phe Pro Asp Phe Lys Ser
                 405                 410                 415    
 Ala Gly Val Thr Leu Arg Ser Gln Arg Met Lys Leu Pro Ser Ser Val
             420                 425                 430        
 Gly Gln Lys Lys Ile Lys Ala Leu Glu Gln Met Leu Leu Glu Leu Gly
         435                 440                 445            
 Val Glu Leu Ser Pro Thr Pro Thr Glu Glu Leu Val His Met Phe Asn
     450                 455                 460                
 Glu Leu Arg Ser Asp Leu Val Leu Leu Tyr Glu Leu Lys Gln Ala Cys
 465                 470                 475                 480
 Ala Asn Cys Glu Tyr Glu Leu Gln Met Leu Arg His Arg His Glu Ala
                 485                 490                 495    
 Leu Ala Arg Ala Gly Val Leu Gly Gly Pro Ala Thr Pro Ala Ser Gly
             500                 505                 510        
 Pro Gly Pro Ala Ser Ala Glu Pro Ala Val Thr Glu Pro Gly Leu Gly
         515                 520                 525            
 Pro Asp Pro Lys Asp Thr Ile Ile Asp Val Val Gly Ala Pro Leu Thr
     530                 535                 540                
 Pro Asn Ser Arg Lys Arg Arg Glu Ser Ala Ser Ser Ser Ser Ser Val
 545                 550                 555                 560
 Lys Lys Ala Lys Lys Pro
                 565    



      <210> 638
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 638
 Leu Thr Arg Ala Pro Pro Pro Ser Thr Gln Val Arg Pro Val Pro Gly
   1               5                  10                  15    
 Pro Pro Ala Gly Ala Val Val Ala Ala Pro Gly Gly Ala Leu Ala Ser
              20                  25                  30        
 Val Ser Phe Asp Ser Arg Asp Ser Lys Met Ala Ala Gln Ser Ala Pro
          35                  40                  45            
 Lys Val Val Leu Lys Ser Thr Thr Lys Met Ser Leu Asn Glu Arg Phe
      50                  55                  60                
 Thr Asn Met Leu Lys Asn Lys Gln Pro Thr Pro Val Asn Ile Arg Ala
  65                  70                  75                  80
 Ser Met Gln Gln Gln Gln Gln Leu Ala Ser Ala Arg Asn Arg Arg Leu
                  85                  90                  95    
 Ala Gln Gln Met Glu Asn Arg Pro Ser Val Gln Ala Ala Leu Lys Leu
             100                 105                 110        
 Lys Gln Ser Leu Lys Gln Arg Leu Gly Lys Ser Asn Ile Gln Ala Arg
         115                 120                 125            
 Leu Gly Arg Pro Ile Gly Ala Leu Ala Arg Gly Ala Ile Gly Gly Arg
     130                 135                 140                
 Gly Leu Pro Ile Ile Gln Arg Gly Leu Pro Arg Gly Gly Leu Arg Gly
 145                 150                 155                 160
 Gly Arg Ala Thr Arg Thr Leu Leu Arg Gly Gly Met Ser Leu Arg Gly
                 165                 170                 175    
 Gln Asn Leu Leu Arg Gly Gly Arg Ala Val Ala Pro Arg Met Gly Leu
             180                 185                 190        
 Arg Arg Gly Gly Val Arg Gly Arg Gly Gly Pro Gly Arg Gly Gly Leu
         195                 200                 205            
 Gly Arg Gly Ala Met Gly Arg Gly Gly Ile Gly Gly Arg Gly Arg Gly
     210                 215                 220                
 Met Ile Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Arg
 225                 230                 235                 240
 Gly Arg Gly Arg Gly Ala Leu Ala Arg Pro Val Leu Thr Lys Glu Gln
                 245                 250                 255    
 Leu Asp Asn Gln Leu Asp Ala Tyr Met Ser Lys Thr Lys Gly His Leu
             260                 265                 270        
 Asp Ala Glu Leu Asp Ala Tyr Met Ala Gln Thr Asp Pro Glu Thr Asn
         275                 280                 285            
 Asp
    



      <210> 639
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 639
 Arg Pro Ala Glu Pro Asp Pro Gly Ser Gly His Pro Glu Pro Lys Ser
   1               5                  10                  15    
 Pro Thr Leu Ser Ala Val Met Ser Ala Glu Val Lys Val Thr Gly Gln
              20                  25                  30        
 Asn Gln Glu Gln Phe Leu Leu Leu Ala Lys Ser Ala Lys Gly Ala Ala
          35                  40                  45            
 Leu Ala Thr Leu Ile His Gln Val Leu Glu Ala Pro Gly Val Tyr Val
      50                  55                  60                
 Phe Gly Glu Leu Leu Asp Met Pro Asn Val Arg Glu Leu Ala Glu Ser
  65                  70                  75                  80
 Asp Phe Ala Ser Thr Phe Arg Leu Leu Thr Val Phe Ala Tyr Gly Thr
                  85                  90                  95    
 Tyr Ala Asp Tyr Leu Ala Glu Ala Arg Asn Leu Pro Pro Leu Thr Glu
             100                 105                 110        
 Ala Gln Lys Asn Lys Leu Arg His Leu Ser Val Val Thr Leu Ala Ala
         115                 120                 125            
 Lys Val Lys Cys Ile Pro Tyr Ala Val Leu Leu Glu Ala Leu Ala Leu
     130                 135                 140                
 Arg Asn Val Arg Gln Leu Glu Asp Leu Val Ile Glu Ala Val Tyr Ala
 145                 150                 155                 160
 Asp Val Leu Arg Gly Ser Leu Asp Gln Arg Asn Gln Arg Leu Glu Val
                 165                 170                 175    
 Asp Tyr Ser Ile Gly Arg Asp Ile Gln Arg Gln Asp Leu Ser Ala Ile
             180                 185                 190        
 Ala Arg Thr Leu Gln Glu Trp Cys Val Gly Cys Glu Val Val Leu Ser
         195                 200                 205            
 Gly Ile Glu Glu Gln Val Ser Arg Ala Asn Gln His Lys Glu Gln Gln
     210                 215                 220                
 Leu Gly Leu Lys Gln Gln Ile Glu Ser Glu Val Ala Asn Leu Lys Lys
 225                 230                 235                 240
 Thr Ile Lys Val Thr Thr Ala Ala Ala Ala Ala Ala Thr Ser Gln Asp
                 245                 250                 255    
 Pro Glu Gln His Leu Thr Glu Leu Arg Glu Pro Ala Pro Gly Thr Asn
             260                 265                 270        
 Gln Arg Gln Pro Ser Lys Lys Ala Ser Lys Gly Lys Gly Leu Arg Gly
         275                 280                 285            
 Ser Ala Lys Ile Trp Ser Lys Ser Asn
     290                 295        



      <210> 640
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 640
 Arg Leu His Val Val Pro Met Ala Arg Tyr Glu Glu Val Ser Val Ser
   1               5                  10                  15    
 Gly Phe Glu Glu Phe His Arg Ala Val Glu Gln His Asn Gly Lys Thr
              20                  25                  30        
 Ile Phe Ala Tyr Phe Thr Gly Ser Lys Asp Ala Gly Gly Lys Ser Trp
          35                  40                  45            
 Cys Pro Asp Cys Val Gln Ala Glu Pro Val Val Arg Glu Gly Leu Lys
      50                  55                  60                
 His Ile Ser Glu Gly Cys Val Phe Ile Tyr Cys Gln Val Gly Glu Lys
  65                  70                  75                  80
 Pro Tyr Trp Lys Asp Pro Asn Asn Asp Phe Arg Lys Asn Leu Lys Val
                  85                  90                  95    
 Thr Ala Val Pro Thr Leu Leu Lys Tyr Gly Thr Pro Gln Lys Leu Val
             100                 105                 110        
 Glu Ser Glu Cys Leu Gln Ala Asn Leu Val Glu Met Leu Phe Ser Glu
         115                 120                 125            
 Asp
    



      <210> 641
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 641
 Leu Phe Tyr Glu Glu Phe Ser Tyr Ala Thr Ile Leu Thr Ile Ser Ser
   1               5                  10                  15    
 Ser Glu Gln Lys Asn Ser Ile Lys Lys Ser Thr Phe Cys Leu Thr Leu
              20                  25                  30        
 Leu Pro Arg Leu Glu Cys Ser Gly Ala Val Met Ala Arg Cys Ser Leu
          35                  40                  45            
 Asn Leu Leu Gly Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Val Ala
      50                  55                  60                
 Gly Thr Thr Gly Ala Cys His His Thr Ser Leu Ile Phe Pro Phe Val
  65                  70                  75                  80
 Leu Tyr Val Asp Ser Thr Gly Leu Thr Leu Lys Thr
                  85                  90        



      <210> 642
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 642
 Asp Pro Arg Val Arg Thr Arg Glu Trp Asp Ser Leu Asn Tyr Glu Asn
   1               5                  10                  15    
 His Ile Tyr Leu Met Pro Phe Ile Tyr Ile Asn Ile Ile Leu Gly Gly
              20                  25                  30        
 Thr Ile Ser Leu Leu Gly Arg Leu Val Tyr Arg Ser His Leu Ile Ser
          35                  40                  45            
 Ser Leu Leu Cys Leu Glu Gly Ile Ile Leu Ser Leu Phe Ile Ile Ala
      50                  55                  60                
 Thr Leu Ile Thr Leu Asn Thr His Ser Leu Leu Thr Asn Ile Gly Pro
  65                  70                  75                  80
 Ile Ala Ile Leu Val Phe Ala Ala Cys Glu Ala Ala Gly Gly Leu Ser
                  85                  90                  95    
 Leu Leu Gly Ser Ile Ser Asn Thr Tyr Gly Leu Asn Tyr Val His Asn
             100                 105                 110        
 Leu Asn Leu Leu Gln Cys
         115            



      <210> 643
      <211> 306
      <212> PRT
      <213> Homo sapiens


      <400> 643
 Ala Glu Cys Glu Glu Val Arg Arg Lys Ser Glu Leu Phe Asn Pro Val
   1               5                  10                  15    
 Ser Leu Asp Cys Lys Leu Arg Gln Lys Ala Ile Ala Glu Val Asp Val
              20                  25                  30        
 Gly Thr Asp Lys Ala Gln Asn Ser Asp Pro Ile Leu Asp Thr Ser Ser
          35                  40                  45            
 Leu Val Pro Gly Cys Ser Ser Val Asp Asn Ile Lys Ser Ser Gln Thr
      50                  55                  60                
 Ser Gln Asn Gln Gly Leu Gly Arg Pro Thr Leu Glu Gly Asp Glu Glu
  65                  70                  75                  80
 Thr Ser Glu Val Glu Tyr Thr Val Asn Lys Gly Pro Ala Ser Ser Asn
                  85                  90                  95    
 Arg Asp Arg Val Pro Pro Ser Ser Glu Ala Ser Glu His His Pro Arg
             100                 105                 110        
 His Arg Val Ser Ser Gln Ala Glu Asp Thr Ser Ser Ser Phe Asp Asn
         115                 120                 125            
 Leu Phe Ile Asp Arg Leu Gln Arg Ile Thr Ile Ala Asp Gln Gly Glu
     130                 135                 140                
 Gln Gln Ser Glu Glu Asn Ala Ser Thr Lys Asn Leu Thr Gly Leu Ser
 145                 150                 155                 160
 Ser Gly Thr Glu Lys Lys Pro His Tyr Met Glu Val Leu Glu Met Arg
                 165                 170                 175    
 Ala Lys Asn Pro Val Pro Gln Leu Arg Lys Phe Lys Thr Asn Val Leu
             180                 185                 190        
 Pro Phe Arg Gln Asn Asp Ser Ser Ser His Cys Gln Lys Ser Gly Ser
         195                 200                 205            
 Pro Ile Ser Ser Glu Glu Arg Arg Arg Arg Asp Lys Gln His Leu Asp
     210                 215                 220                
 Asp Ile Thr Ala Ala Arg Leu Leu Pro Leu His His Met Pro Thr Gln
 225                 230                 235                 240
 Leu Leu Ser Ile Glu Glu Ser Leu Ala Leu Gln Lys Gln Gln Lys Gln
                 245                 250                 255    
 Asn Tyr Glu Glu Met Gln Ala Lys Leu Ala Ala Gln Lys Leu Ala Glu
             260                 265                 270        
 Arg Leu Asn Ile Lys Met Arg Ser Tyr Asn Pro Glu Gly Glu Ser Ser
         275                 280                 285            
 Gly Arg Tyr Arg Glu Val Arg Asp Glu Asp Asp Asp Trp Ser Ser Asp
     290                 295                 300                
 Glu Phe
 305    



      <210> 644
      <211> 727
      <212> PRT
      <213> Homo sapiens


      <400> 644
 Arg Pro Tyr Leu Gly Leu Leu Lys Met Ala Ala Leu Glu Glu Glu Phe
   1               5                  10                  15    
 Thr Leu Ser Ser Val Val Leu Ser Ala Gly Pro Glu Gly Leu Leu Gly
              20                  25                  30        
 Val Glu Gln Ser Asp Lys Thr Asp Gln Phe Leu Val Thr Asp Ser Gly
          35                  40                  45            
 Arg Thr Val Ile Leu Tyr Lys Val Ser Asp Gln Lys Pro Leu Gly Ser
      50                  55                  60                
 Trp Ser Val Lys Gln Gly Gln Ile Ile Thr Cys Pro Ala Val Cys Asn
  65                  70                  75                  80
 Phe Gln Thr Gly Glu Tyr Val Val Val His Asp Asn Lys Val Leu Arg
                  85                  90                  95    
 Ile Trp Asn Asn Glu Asp Val Asn Leu Asp Lys Val Phe Lys Ala Thr
             100                 105                 110        
 Leu Ser Ala Glu Val Tyr Arg Ile Leu Ser Val Gln Gly Thr Glu Pro
         115                 120                 125            
 Leu Val Leu Phe Lys Glu Gly Ala Val Arg Gly Leu Glu Ala Leu Leu
     130                 135                 140                
 Ala Asp Pro Gln Gln Lys Ile Glu Thr Val Ile Ser Asp Glu Glu Val
 145                 150                 155                 160
 Ile Lys Trp Thr Lys Phe Phe Val Val Phe Arg His Pro Val Leu Ile
                 165                 170                 175    
 Phe Ile Thr Glu Lys His Gly Asn Tyr Phe Ala Tyr Val Gln Met Phe
             180                 185                 190        
 Asn Ser Arg Ile Leu Thr Lys Tyr Thr Leu Leu Leu Gly Gln Asp Glu
         195                 200                 205            
 Asn Ser Val Ile Lys Ser Phe Thr Ala Ser Val Asp Arg Lys Phe Ile
     210                 215                 220                
 Ser Leu Met Ser Leu Ser Ser Asp Gly Cys Ile Tyr Glu Thr Leu Ile
 225                 230                 235                 240
 Pro Ile Arg Pro Ala Asp Pro Glu Lys Asn Gln Ser Leu Val Lys Ser
                 245                 250                 255    
 Leu Leu Leu Lys Ala Val Val Ser Gly Asn Ala Arg Asn Gly Val Ala
             260                 265                 270        
 Leu Thr Ala Leu Asp Gln Asp His Val Ala Val Leu Gly Ser Pro Leu
         275                 280                 285            
 Ala Ala Ser Lys Glu Cys Leu Ser Val Trp Asn Ile Lys Phe Gln Thr
     290                 295                 300                
 Leu Gln Thr Ser Lys Glu Leu Pro Gln Gly Thr Ser Gly Gln Leu Trp
 305                 310                 315                 320
 Tyr Tyr Gly Glu His Leu Phe Met Leu His Gly Lys Ser Leu Thr Val
                 325                 330                 335    
 Ile Pro Tyr Lys Cys Glu Val Ser Ser Leu Ala Gly Ala Leu Gly Lys
             340                 345                 350        
 Leu Lys His Ser Gln Asp Pro Gly Thr His Val Val Ser His Phe Val
         355                 360                 365            
 Asn Trp Glu Thr Pro Gln Gly Cys Gly Leu Gly Phe Gln Asn Ser Glu
     370                 375                 380                
 Gln Ser Arg Arg Ile Leu Arg Arg Arg Lys Ile Glu Val Ser Leu Gln
 385                 390                 395                 400
 Pro Glu Val Pro Pro Ser Lys Gln Leu Leu Ser Thr Ile Met Lys Asp
                 405                 410                 415    
 Ser Glu Lys His Ile Glu Val Glu Val Arg Lys Phe Leu Ala Leu Lys
             420                 425                 430        
 Gln Thr Pro Asp Phe His Thr Val Ile Gly Asp Thr Val Thr Gly Leu
         435                 440                 445            
 Leu Glu Arg Cys Lys Ala Glu Pro Ser Phe Tyr Pro Arg Asn Cys Leu
     450                 455                 460                
 Met Gln Leu Ile Gln Thr His Val Leu Ser Tyr Ser Leu Cys Pro Asp
 465                 470                 475                 480
 Leu Met Glu Ile Ala Leu Lys Lys Lys Asp Val Gln Leu Leu Gln Leu
                 485                 490                 495    
 Cys Leu Gln Gln Phe Pro Asp Ile Pro Glu Ser Val Thr Cys Ala Cys
             500                 505                 510        
 Leu Lys Ile Phe Leu Ser Ile Gly Asp Asp Ser Leu Gln Glu Thr Asp
         515                 520                 525            
 Val Asn Met Glu Ser Val Phe Asp Tyr Ser Ile Asn Ser Val His Asp
     530                 535                 540                
 Glu Lys Met Glu Glu Gln Thr Glu Ile Leu Gln Asn Gly Phe Asn Pro
 545                 550                 555                 560
 Glu Glu Asp Lys Cys Asn Asn Cys Asp Gln Glu Leu Asn Lys Lys Pro
                 565                 570                 575    
 Gln Asp Glu Thr Lys Glu Ser Thr Ser Cys Pro Val Val Gln Lys Arg
             580                 585                 590        
 Ala Ala Leu Leu Asn Ala Ile Leu His Ser Ala Tyr Ser Glu Thr Phe
         595                 600                 605            
 Leu Leu Pro His Leu Lys Asp Ile Pro Ala Gln His Ile Thr Leu Phe
     610                 615                 620                
 Leu Lys Tyr Leu Tyr Phe Leu Tyr Leu Lys Cys Ser Glu Asn Ala Thr
 625                 630                 635                 640
 Met Thr Leu Pro Gly Ile His Pro Pro Thr Leu Asn Gln Ile Met Asp
                 645                 650                 655    
 Trp Ile Cys Leu Leu Leu Asp Ala Asn Phe Thr Val Val Val Met Met
             660                 665                 670        
 Pro Glu Ala Lys Arg Leu Leu Ile Asn Leu Tyr Lys Leu Val Lys Ser
         675                 680                 685            
 Gln Ile Ser Val Tyr Ser Glu Leu Asn Lys Ile Glu Val Ser Phe Arg
     690                 695                 700                
 Glu Leu Gln Lys Leu Asn Gln Glu Lys Asn Asn Arg Gly Leu Tyr Ser
 705                 710                 715                 720
 Ile Glu Val Leu Glu Leu Phe
                 725        



      <210> 645
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 645
 Trp Trp Pro Val Leu Arg Arg Trp Thr Met Lys Thr Phe Arg Trp Lys
   1               5                  10                  15    
 Val Lys Pro Gly Met Asp Val Ala Ser Val Pro Ser Val Arg Lys Val
              20                  25                  30        
 Arg Phe Gly Asp Gly Tyr Ser Gln Arg Ala Pro Ala Gly Leu Asn Ala
          35                  40                  45            
 Asn Leu Lys Thr Tyr Ser Val Thr Leu Ser Val Pro Arg Glu Glu Ala
      50                  55                  60                
 Thr Val Leu Glu Ser Phe Leu Glu Glu His Gly Gly Trp Lys Ser Phe
  65                  70                  75                  80
 Leu Trp Thr Pro Pro Tyr Glu Trp Arg Gln Ile Lys Val Thr Cys Ala
                  85                  90                  95    
 Lys Trp Ser Ser Arg Val Ser Met Leu Arg Val Glu Phe Ser Ala Glu
             100                 105                 110        
 Phe Glu Gln Val Val Asn
         115            



      <210> 646
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 646
 Gln Ser Val Trp Val Ala Gln Pro Pro Ala Val Thr Ala Asp Leu Gln
   1               5                  10                  15    
 Phe Leu Glu Gly Ser Gly Glu Lys Asn Ala Pro Thr Ala Val Leu Arg
              20                  25                  30        
 Lys Arg Gln Glu Glu Met Arg Pro Leu Asp Ile Asp Glu Val Glu Ala
          35                  40                  45            
 Pro Glu Glu Val Glu Val Leu Glu Pro Glu Glu Asp Phe Glu Gln Phe
      50                  55                  60                
 Leu Leu Pro Val Ile Asn Glu Met Arg Glu Asp Ile Ala Ser Leu Ile
  65                  70                  75                  80
 Arg Glu His Gly Arg Ala Tyr Leu Arg Thr Arg Ser Lys Leu Trp Glu
                  85                  90                  95    
 Met Asp Asn Met Leu Ile Gln Ile Lys Thr Gln Val Glu Ala Ser Glu
             100                 105                 110        
 Glu Ser Ala Leu Asn His Val Gln His Pro Ser Gly Glu Ala Asp Glu
         115                 120                 125            
 Arg Val Ser Glu Leu Cys Glu Lys Ala Glu Glu Lys Ala Lys Glu Ile
     130                 135                 140                
 Ala Lys Met Ala Glu Met Leu Val Glu Leu Val Trp Arg Ile Glu Arg
 145                 150                 155                 160
 Ser Glu Ser Ser
                



      <210> 647
      <211> 171
      <212> PRT
      <213> Homo sapiens


      <400> 647
 Gln Ala Ser Gly Leu Tyr Ser Phe Leu Thr Leu Ala Pro Met Thr His
   1               5                  10                  15    
 Leu Leu Leu Thr Ala Thr Val Thr Pro Ser Glu Gln Asn Ser Ser Arg
              20                  25                  30        
 Glu Pro Gly Trp Glu Thr Ala Met Ala Lys Asp Ile Leu Gly Glu Ala
          35                  40                  45            
 Gly Leu His Phe Asp Glu Leu Asn Lys Leu Arg Val Leu Asp Pro Glu
      50                  55                  60                
 Val Thr Gln Gln Thr Ile Glu Leu Lys Glu Glu Cys Lys Asp Phe Val
  65                  70                  75                  80
 Asp Lys Ile Gly Gln Phe Gln Lys Ile Val Gly Gly Leu Ile Glu Leu
                  85                  90                  95    
 Val Asp Gln Leu Ala Lys Glu Ala Glu Asn Glu Lys Met Lys Ala Ile
             100                 105                 110        
 Gly Ala Arg Asn Leu Leu Lys Ser Ile Ala Lys Gln Arg Glu Ala Gln
         115                 120                 125            
 Gln Gln Gln Leu Gln Ala Leu Ile Ala Glu Lys Lys Met Gln Leu Glu
     130                 135                 140                
 Arg Tyr Arg Val Glu Tyr Glu Ala Leu Cys Lys Val Glu Ala Glu Gln
 145                 150                 155                 160
 Asn Glu Phe Ile Asp Gln Phe Ile Phe Gln Lys
                 165                 170    



      <210> 648
      <211> 243
      <212> PRT
      <213> Homo sapiens


      <400> 648
 Thr Gly Asn Lys Met Gln Asp Pro Asn Ala Asp Thr Glu Trp Asn Asp
   1               5                  10                  15    
 Ile Leu Arg Lys Lys Gly Ile Leu Pro Pro Lys Glu Ser Leu Lys Glu
              20                  25                  30        
 Leu Glu Glu Glu Ala Glu Glu Glu Gln Arg Ile Leu Gln Gln Ser Val
          35                  40                  45            
 Val Lys Thr Tyr Glu Asp Met Thr Leu Glu Glu Leu Glu Asp His Glu
      50                  55                  60                
 Asp Glu Phe Asn Glu Glu Asp Glu Arg Ala Ile Glu Met Tyr Arg Arg
  65                  70                  75                  80
 Arg Arg Leu Ala Glu Trp Lys Ala Thr Lys Leu Lys Asn Lys Phe Gly
                  85                  90                  95    
 Glu Val Leu Glu Ile Ser Gly Lys Asp Tyr Val Gln Glu Val Thr Lys
             100                 105                 110        
 Ala Gly Glu Gly Leu Trp Val Ile Leu His Leu Tyr Lys Gln Gly Ile
         115                 120                 125            
 Pro Leu Cys Ala Leu Ile Asn Gln His Leu Ser Gly Leu Ala Arg Lys
     130                 135                 140                
 Phe Pro Asp Val Lys Phe Ile Lys Ala Ile Ser Thr Thr Cys Ile Pro
 145                 150                 155                 160
 Asn Tyr Pro Asp Arg Asn Leu Pro Thr Ile Phe Val Tyr Leu Glu Gly
                 165                 170                 175    
 Asp Ile Lys Ala Gln Phe Ile Gly Pro Leu Val Phe Gly Gly Met Asn
             180                 185                 190        
 Leu Thr Arg Asp Glu Leu Glu Trp Lys Leu Ser Glu Ser Gly Ala Ile
         195                 200                 205            
 Met Thr Asp Leu Glu Glu Asn Pro Lys Lys Pro Ile Glu Asp Val Leu
     210                 215                 220                
 Leu Ser Ser Val Arg Arg Ser Val Leu Met Lys Arg Asp Ser Asp Ser
 225                 230                 235                 240
 Glu Gly Asp
            



      <210> 649
      <211> 68
      <212> PRT
      <213> Homo sapiens


      <400> 649
 Met Thr Arg Gln Glu Glu Leu Ala Ala Ala Arg Ala Ala Leu His Asp
   1               5                  10                  15    
 Leu Met Thr Gly Lys Arg Val Ala Thr Val Gln Lys Asp Gly Arg Arg
              20                  25                  30        
 Val Glu Phe Thr Ala Thr Ser Val Ser Asp Leu Lys Lys Tyr Ile Ala
          35                  40                  45            
 Glu Leu Glu Val Gln Thr Gly Met Thr Gln Arg Arg Thr Gly Pro Ala
      50                  55                  60                
 Gly Phe Tyr Val
  65            



      <210> 650
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 650
 Arg Ser Tyr Phe Pro Tyr Ser Pro Gly Met Phe Gly Asp Asp Cys His
   1               5                  10                  15    
 Gln Leu Cys Asp Cys Glu Gly Glu Thr Phe Cys His Pro Lys Thr Glu
              20                  25                  30        
 Lys Cys Leu Cys Pro Arg Gly Arg Thr Gly Ala Arg Cys Asp Ala Gly
          35                  40                  45            





      <210> 651
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 651
 Leu Arg Met Thr Thr Ala Thr Arg Gln Glu Val Leu Gly Leu Tyr Arg
   1               5                  10                  15    
 Ser Ile Phe Arg Leu Ala Arg Lys Trp Gln Ala Thr Ser Gly Gln Met
              20                  25                  30        
 Glu Asp Thr Ile Lys Glu Lys Gln Tyr Ile Leu Asn Glu Ala Arg Thr
          35                  40                  45            
 Leu Phe Arg Lys Asn Lys Asn Leu Thr Asp Thr Asp Leu Ile Lys Gln
      50                  55                  60                
 Cys Ile Asp Glu Cys Thr Ala Arg Ile Glu Ile Gly Leu His Tyr Lys
  65                  70                  75                  80
 Ile Pro Tyr Pro Arg Pro Ile His Leu Pro Pro Met Gly Leu Thr Pro
                  85                  90                  95    
 Leu Arg Gly Arg Gly Leu Arg Ser Gln Glu Lys Leu Arg Lys Leu Ser
             100                 105                 110        
 Lys Pro Val Tyr Leu Arg Ser His Asp Glu Val Ser
         115                 120                



      <210> 652
      <211> 439
      <212> PRT
      <213> Homo sapiens


      <400> 652
 Cys Asp Ala Pro Leu Gly Gly Ser Ile Ala Gly Pro Phe Asp Gln Leu
   1               5                  10                  15    
 Glu Glu Ile Leu Gly Trp Glu Ser Ala Ala Ala His Ser Ala Glu Leu
              20                  25                  30        
 Val Ala Lys Gly Thr Val Gly Lys Arg Lys Trp Gly Cys Ala Gly Ala
          35                  40                  45            
 Ser Ser Ser Gly Ser Ala Leu Leu Pro Pro Cys Arg Glu Leu Leu Met
      50                  55                  60                
 Gly His Arg Phe Leu Arg Gly Leu Leu Thr Leu Leu Leu Pro Pro Pro
  65                  70                  75                  80
 Pro Leu Tyr Thr Arg His Arg Met Leu Gly Pro Glu Ser Val Pro Pro
                  85                  90                  95    
 Pro Lys Arg Ser Arg Ser Lys Leu Met Ala Pro Pro Arg Ile Gly Thr
             100                 105                 110        
 His Asn Gly Thr Phe His Cys Asp Glu Ala Leu Ala Cys Ala Leu Leu
         115                 120                 125            
 Arg Leu Leu Pro Glu Tyr Arg Asp Ala Glu Ile Val Arg Thr Arg Asp
     130                 135                 140                
 Pro Glu Lys Leu Ala Ser Cys Asp Ile Val Val Asp Val Gly Gly Glu
 145                 150                 155                 160
 Tyr Asp Pro Arg Arg His Arg Tyr Asp His His Gln Arg Ser Phe Thr
                 165                 170                 175    
 Glu Thr Met Ser Ser Leu Ser Pro Gly Lys Pro Trp Gln Thr Lys Leu
             180                 185                 190        
 Ser Ser Ala Gly Leu Ile Tyr Leu His Phe Gly His Lys Leu Leu Ala
         195                 200                 205            
 Gln Leu Leu Gly Thr Ser Glu Glu Asp Ser Met Val Gly Thr Leu Tyr
     210                 215                 220                
 Asp Lys Met Tyr Glu Asn Phe Val Glu Glu Val Asp Ala Val Asp Asn
 225                 230                 235                 240
 Gly Ile Ser Gln Trp Ala Glu Gly Glu Pro Arg Tyr Ala Leu Thr Thr
                 245                 250                 255    
 Thr Leu Ser Ala Arg Val Ala Arg Leu Asn Pro Thr Trp Asn His Pro
             260                 265                 270        
 Asp Gln Asp Thr Glu Ala Gly Phe Lys Arg Ala Met Asp Leu Val Gln
         275                 280                 285            
 Glu Glu Phe Leu Gln Arg Leu Asp Phe Tyr Gln His Ser Trp Leu Pro
     290                 295                 300                
 Ala Arg Ala Leu Val Glu Glu Ala Leu Ala Gln Arg Phe Gln Val Asp
 305                 310                 315                 320
 Pro Ser Gly Glu Ile Val Glu Leu Ala Lys Gly Ala Cys Pro Trp Lys
                 325                 330                 335    
 Glu His Leu Tyr His Leu Glu Ser Gly Leu Ser Pro Pro Val Ala Ile
             340                 345                 350        
 Phe Phe Val Ile Tyr Thr Asp Gln Ala Gly Gln Trp Arg Ile Gln Cys
         355                 360                 365            
 Val Pro Lys Glu Pro His Ser Phe Gln Ser Arg Leu Pro Leu Pro Glu
     370                 375                 380                
 Pro Trp Arg Gly Leu Arg Asp Glu Ala Leu Asp Gln Val Ser Gly Ile
 385                 390                 395                 400
 Pro Gly Cys Ile Phe Val His Ala Ser Gly Phe Ile Gly Gly His Arg
                 405                 410                 415    
 Thr Arg Glu Gly Ala Leu Ser Met Ala Arg Ala Thr Leu Ala Gln Arg
             420                 425                 430        
 Ser Tyr Leu Pro Gln Ile Ser
         435                



      <210> 653
      <211> 550
      <212> PRT
      <213> Homo sapiens


      <400> 653
 Gln Asn Ala Lys Val Gly Ser Glu Ala Ile Gln Val Leu Pro Ala Phe
   1               5                  10                  15    
 Pro Arg Glu Val Gln Arg Leu Pro Glu Pro Ala Lys Ser Cys Arg Gln
              20                  25                  30        
 Arg Gln Leu Glu Ala Arg Lys Ala Ala Ala Glu Lys Lys Lys Ile Gln
          35                  40                  45            
 Lys Glu Lys Leu Ser Thr Pro Glu Lys Ile Lys Gln Glu Ala Leu Glu
      50                  55                  60                
 Leu Ala Gly Ile Thr Ser Asp Pro Gly Leu Ser Leu Lys Gly Gly Leu
  65                  70                  75                  80
 Ser Gln Gln Gly Leu Lys Pro Ser Leu Lys Val Glu Pro Gln Asn His
                  85                  90                  95    
 Phe Ser Ser Phe Lys Tyr Ser Gly Asn Ala Val Val Glu Ser Tyr Ser
             100                 105                 110        
 Val Leu Gly Asn Cys Arg Pro Ser Asp Pro Tyr Ser Met Asn Ser Val
         115                 120                 125            
 Tyr Ser Tyr His Ser Tyr Tyr Ala Gln Pro Ser Leu Thr Ser Val Asn
     130                 135                 140                
 Gly Phe His Ser Lys Tyr Ala Leu Pro Ser Phe Ser Tyr Tyr Gly Phe
 145                 150                 155                 160
 Pro Ser Ser Asn Pro Val Phe Pro Ser Gln Phe Leu Gly Pro Gly Ala
                 165                 170                 175    
 Trp Gly His Ser Gly Ser Ser Gly Ser Phe Glu Lys Lys Pro Asp Leu
             180                 185                 190        
 His Ala Leu His Asn Ser Leu Ser Pro Ala Tyr Gly Gly Ala Glu Phe
         195                 200                 205            
 Ala Glu Leu Pro Ser Gln Ala Val Pro Thr Asp Ala His His Pro Thr
     210                 215                 220                
 Pro His His Gln Gln Pro Ala Tyr Pro Gly Pro Lys Glu Tyr Leu Leu
 225                 230                 235                 240
 Pro Lys Ala Pro Leu Leu His Ser Val Ser Arg Asp Pro Ser Pro Phe
                 245                 250                 255    
 Ala Gln Ser Ser Asn Cys Tyr Asn Arg Ser Ile Lys Gln Glu Pro Val
             260                 265                 270        
 Asp Pro Leu Thr Gln Ala Glu Pro Val Pro Arg Asp Ala Gly Lys Met
         275                 280                 285            
 Gly Lys Thr Pro Leu Ser Glu Val Ser Gln Asn Gly Gly Pro Ser His
     290                 295                 300                
 Leu Trp Gly Gln Tyr Ser Gly Gly Pro Ser Met Ser Pro Lys Arg Thr
 305                 310                 315                 320
 Asn Gly Val Gly Gly Ser Trp Gly Val Phe Ser Ser Gly Glu Ser Pro
                 325                 330                 335    
 Ala Ile Val Pro Asp Lys Leu Ser Ser Phe Gly Ala Ser Cys Leu Ala
             340                 345                 350        
 Pro Ser His Phe Thr Asp Gly Gln Trp Gly Leu Phe Pro Gly Glu Gly
         355                 360                 365            
 Gln Gln Ala Ala Ser His Ser Gly Gly Arg Leu Arg Gly Lys Pro Trp
     370                 375                 380                
 Ser Pro Cys Lys Phe Gly Asn Ser Thr Ser Ala Leu Ala Gly Pro Ser
 385                 390                 395                 400
 Leu Thr Glu Lys Pro Trp Ala Leu Gly Ala Gly Asp Phe Asn Ser Ala
                 405                 410                 415    
 Leu Lys Gly Ser Pro Gly Phe Gln Asp Lys Leu Trp Asn Pro Met Lys
             420                 425                 430        
 Gly Glu Glu Gly Arg Ile Pro Ala Ala Gly Ala Ser Gln Leu Val Phe
         435                 440                 445            
 Tyr Gln His Lys Asn Leu Asn Gln Pro Asn His Gly Leu Ala Leu Trp
     450                 455                 460                
 Glu Ala Lys Met Lys Gln Leu Ala Glu Arg Ala Arg Ala Arg Gln Glu
 465                 470                 475                 480
 Glu Ala Ala Arg Leu Gly Leu Gly Gln Gln Glu Ala Lys Leu Tyr Gly
                 485                 490                 495    
 Lys Lys Arg Lys Trp Gly Gly Thr Val Val Ala Glu Pro Gln Gln Lys
             500                 505                 510        
 Glu Lys Lys Gly Val Val Pro Thr Arg Gln Ala Leu Ala Val Pro Thr
         515                 520                 525            
 Asp Ser Ala Val Thr Val Ser Ser Tyr Ala Tyr Thr Lys Val Thr Gly
     530                 535                 540                
 Pro Tyr Ser Arg Trp Ile
 545                 550



      <210> 654
      <211> 221
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(218)
      <223> Xaa = any amino acid or nothing 


      <400> 654
 Lys Tyr Arg Trp Gly Phe Thr Val Leu Ala Arg Met Val Ser Ile Ser
   1               5                  10                  15    
 Xaa Ser Arg Asp Leu Pro Val Ser Ala Ser Gln Ser Ala Gly Ile Ile
              20                  25                  30        
 Gly Val Ser His Arg Ala Arg Pro Arg Phe Tyr Phe Leu Ile Ser Leu
          35                  40                  45            
 Trp His Leu Leu Tyr Phe Leu Ile Phe Phe Gln Ser Xaa Gln Xaa Met
      50                  55                  60                
 Lys Asn Leu Cys Leu Lys Lys Leu Pro Asp Asp Ser Asn Tyr Cys Ser
  65                  70                  75                  80
 Cys Thr Thr Leu Phe Lys Thr Gly Asn Leu Ser Cys Leu Pro Asp Ile
                  85                  90                  95    
 Leu Cys Thr Lys Ser Xaa Tyr Ser Val Ser Cys Lys Ser Phe Ala Asn
             100                 105                 110        
 Ser Tyr Ile Gln Lys Lys His Asp Lys Met Xaa Lys Glu Asn Gly Val
         115                 120                 125            
 Arg Xaa Gly Ile Ile Asn Asn Leu Arg Leu Ser Ile Ile Leu Ile Leu
     130                 135                 140                
 Ile Leu Ile Ser Xaa Leu Ser Tyr Phe Asn Asp Phe His Xaa Asn Ser
 145                 150                 155                 160
 Gly Thr Ser Leu Ile Val Ser Xaa His Tyr Tyr Leu Asn Lys His Asp
                 165                 170                 175    
 Leu His Pro Asn Tyr Phe Ile Leu Leu Phe Cys Phe Ser Phe Val Arg
             180                 185                 190        
 Gln Gly Leu Arg Ser Val Ala Gln Ala Gly Val Gln Trp Cys Asp Leu
         195                 200                 205            
 Gly Ser Leu Glu Pro Pro Pro Pro Arg Phe
     210                 215            



      <210> 655
      <211> 100
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(99)
      <223> Xaa = any amino acid or nothing 


      <400> 655
 Ser Lys Ser Pro Pro Pro Lys Arg Lys Leu Phe Pro Ser Ser Pro Pro
   1               5                  10                  15    
 Lys Thr Phe Tyr Pro Pro Pro His Ser Gly Val Phe Pro Pro Phe Pro
              20                  25                  30        
 Pro Xaa Asn Phe Phe Phe Ser Pro Arg Gly Leu Ile Phe Gly Gly Gly
          35                  40                  45            
 Phe Phe Gln Phe Phe Pro Pro Pro Lys Lys Arg Phe Phe Ser Lys Ile
      50                  55                  60                
 Pro Glu Ala Phe Leu Lys Val Pro Pro Lys Arg Lys Lys Ile Val Phe
  65                  70                  75                  80
 Ala Thr Ala Pro Val Tyr Phe Gly Pro Pro Arg Glu Phe Phe Lys Gly
                  85                  90                  95    
 Pro Pro Pro
            



      <210> 656
      <211> 72
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(72)
      <223> Xaa = any amino acid or nothing 


      <400> 656
 Pro Ser Ser Ser Ser Pro Phe Phe Phe Phe Phe Pro Pro Pro Gln Lys
   1               5                  10                  15    
 Gly Ile Phe Phe Pro Pro Phe Phe Phe Cys Phe Pro Arg Val Phe Ser
              20                  25                  30        
 Pro Pro Pro Phe Phe Ile Pro Pro Pro Arg Ile Phe Phe Leu Gly Pro
          35                  40                  45            
 Leu Lys Lys Lys Lys Thr Pro Pro Pro Pro Gly Gly Lys Asn Phe Phe
      50                  55                  60                
 Phe Xaa Arg Ala Pro Pro Ser Pro
  65                  70        



      <210> 657
      <211> 27
      <212> PRT
      <213> Homo sapiens


      <400> 657
 Gly Tyr Trp Gly Cys Ala Ile Gly Lys Ala Arg Gln Ala Ala Lys Thr
   1               5                  10                  15    
 Glu Ile Glu Lys Leu Gln Val Ile Ile Asn Ala
              20                  25        



      <210> 658
      <211> 73
      <212> PRT
      <213> Homo sapiens


      <400> 658
 Tyr Pro Met Phe Gln Val Gln Pro Val Gln His Val Tyr Pro Ala Gln
   1               5                  10                  15    
 Val Gln Tyr Val Glu Gly Gly Asp Ala Val Tyr Thr Asn Gly Ala Met
              20                  25                  30        
 Cys Val Leu Leu Pro Arg Ala Thr Pro Gly Thr Leu Ser Leu Thr Pro
          35                  40                  45            
 Ala Phe Ala Thr Trp Gly Gly Ile Lys Gln Ile Pro Leu Pro Tyr Ala
      50                  55                  60                
 Phe Gly Asp Val Phe Thr Lys Tyr Cys
  65                  70            



      <210> 659
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 659
 His Arg Pro Asp Gly Cys Pro Asp Ile Gly Pro Thr Gly Glu Leu Ser
   1               5                  10                  15    
 Gly Ser Leu Lys Ile Pro Asn Arg Asp Ser Gly Ile Asp Ser Pro Ser
              20                  25                  30        
 Ser Ser Val Ala Gly Glu Asn Phe Pro Cys Glu Glu Gly Leu Glu Ala
          35                  40                  45            
 Gly Pro Ser Pro Thr Val Leu Gly Ala His Ala Glu Met Ala Leu Asp
      50                  55                  60                
 Ser Gln Val Pro Lys Val Thr Pro Gln Glu Glu Ala Asp Ser Asp Val
  65                  70                  75                  80
 Gly Glu Glu Pro Asp Ser Glu Asn Thr Pro Gln Lys Ala Asp Lys Asp
                  85                  90                  95    
 Ala Gly Leu Ala Gln His Ser Gly Pro Gln Lys Leu Leu His Ile Ala
             100                 105                 110        
 Gln Glu Leu Leu His Thr Glu Glu Thr Tyr Val Lys Arg Leu His Leu
         115                 120                 125            
 Leu Asp Gln Val Phe Cys Thr Arg Leu Thr Asp Ala Gly Ile Pro Pro
     130                 135                 140                
 Glu Val Ile Met Gly Ile Phe Ser Asn Ile Ser Ser Ile His Arg Phe
 145                 150                 155                 160
 His Gly Gln Phe Leu Leu Pro Glu Leu Lys Thr Arg Ile Thr Glu Glu
                 165                 170                 175    
 Trp Asp Thr Asn Pro Arg Leu Gly Asp Ile Leu Gln Lys Leu Ala Pro
             180                 185                 190        
 Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg Ala Val
         195                 200                 205            
 Gly Leu Val Ser Thr Trp Thr Gln Arg Ser Pro Leu Phe Lys Asp Val
     210                 215                 220                
 Val His Ser Ile Gln Val Arg Arg Arg Arg Gly
 225                 230                 235



      <210> 660
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 660
 Met Ala Glu Met Gln Leu Ala Glu Leu Arg Ala Glu Ile Lys His Phe
   1               5                  10                  15    
 Val Ser Glu Arg Lys Tyr Asp Glu Glu Leu Gly Lys Ala Ala Arg Phe
              20                  25                  30        
 Ser Cys Asp Ile Glu Gln Leu Lys Ala Gln Ile Met Leu Cys Gly Glu
          35                  40                  45            
 Ile Pro His Pro Lys Asn Asn Tyr Ser Ser Arg Thr Pro Cys Ser Ser
      50                  55                  60                
 Leu Leu Pro Leu Leu Asn Ala His Ala Ala Thr Ser Gly Lys Gln Ser
  65                  70                  75                  80
 Asn Phe Ser Arg Lys Ser Ser Thr His Asn Lys Pro Ser Glu Gly Lys
                  85                  90                  95    
 Ala Ala Asn Pro Lys Met Val Ser Ser Leu Pro Ser Thr Ala Asp Pro
             100                 105                 110        
 Ser His Gln Thr Met Thr Ala Asn Lys Gln Asn Gly Glu
         115                 120                 125



      <210> 661
      <211> 125
      <212> PRT
      <213> Homo sapiens


      <400> 661
 Met Ala Glu Met Gln Leu Ala Glu Leu Arg Ala Glu Ile Lys His Phe
   1               5                  10                  15    
 Val Ser Glu Arg Lys Tyr Asp Glu Glu Leu Gly Lys Ala Ala Arg Phe
              20                  25                  30        
 Ser Cys Asp Ile Glu Gln Leu Lys Ala Gln Ile Met Leu Cys Gly Glu
          35                  40                  45            
 Ile Pro His Pro Lys Asn Asn Tyr Ser Ser Arg Thr Pro Cys Ser Ser
      50                  55                  60                
 Leu Leu Pro Leu Leu Asn Ala His Ala Ala Thr Ser Gly Lys Gln Ser
  65                  70                  75                  80
 Asn Phe Ser Arg Lys Ser Ser Thr His Asn Lys Pro Ser Glu Gly Lys
                  85                  90                  95    
 Ala Ala Asn Pro Lys Met Val Ser Ser Leu Pro Ser Thr Ala Asp Pro
             100                 105                 110        
 Ser His Gln Thr Met Thr Ala Asn Lys Gln Asn Gly Glu
         115                 120                 125



      <210> 662
      <211> 261
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(259)
      <223> Xaa = any amino acid or nothing 


      <400> 662
 Thr Leu Gln Thr Leu Ala Pro Ala Thr Val Gln Thr Val Ala Ala Pro
   1               5                  10                  15    
 Gln Val Gln Gln Val Pro Val Ser Gly Trp Lys Gly Phe Arg Glu Ala
              20                  25                  30        
 Leu Val Gly Ala Val Asn Trp Ser Leu Val Glu Asp Val Val Phe Met
          35                  40                  45            
 Ala Ala Val Gln Asn Pro Ala Leu Thr Ala Leu Thr Thr Pro Ile Gln
      50                  55                  60                
 Thr Ala Ala Leu Gln Val Pro Val Arg Ala Ala Phe Ser Pro Thr Leu
  65                  70                  75                  80
 Leu Pro Pro Pro Leu Phe Leu Glu Val Leu Val Phe Arg Asp Val Lys
                  85                  90                  95    
 Gln Val Pro Gly Gly Val Lys Gln Leu Glu Pro Pro Lys Glu Gly Glu
             100                 105                 110        
 Arg Arg Thr Thr His Asn Ile Ile Glu Lys Arg Ile Arg Ser Ser Ile
         115                 120                 125            
 Asn Asp Lys Ile Ile Glu Leu Lys Asp Leu Val Met Gly Thr Asp Ala
     130                 135                 140                
 Lys Val Gly Ala Lys Gln Asn Cys Val Leu Cys Ser Thr Ile Ser Pro
 145                 150                 155                 160
 Leu Pro Val Phe Ala Ser Gly Ala Xaa Arg Ser Pro Arg Leu Lys Val
                 165                 170                 175    
 Ser Glu Tyr Lys Thr Glu Leu Glu Val Leu Phe Tyr Xaa Ser Ile Leu
             180                 185                 190        
 Val Ser Cys Gln Asp Tyr Lys Ile Leu Lys Asn Ile Arg Asp Trp Xaa
         195                 200                 205            
 Gly Leu Ile Arg Gln Xaa Pro Ala Glu Thr Phe Asp Ser Phe Gly Tyr
     210                 215                 220                
 Ala Leu Gln Leu Met Gly Thr Pro Leu Ser Glu Ala Glu Lys Asp Ala
 225                 230                 235                 240
 Cys His Ser Val Val Pro Asp Thr Gly Leu Cys Val Pro Trp Ser Gln
                 245                 250                 255    
 Leu Met Ala
            



      <210> 663
      <211> 105
      <212> PRT
      <213> Homo sapiens


      <400> 663
 Tyr Ile Thr Pro Gly Ile Cys Pro Ser Leu Ser Thr Met Lys Ala Ile
   1               5                  10                  15    
 Val Glu Cys Ala Gly Gly Lys Val Leu Ser Lys Gln Pro Ser Phe Arg
              20                  25                  30        
 Lys Leu Met Glu His Lys Gln Asn Ser Val Gly Arg Val Glu Ser Ala
          35                  40                  45            
 Ser Glu Ser Val Ile Ala Leu Tyr His Ile Gln Arg Ser Val Thr Glu
      50                  55                  60                
 Lys Leu Ile Phe Phe Ser Leu Ser Leu Ser Glu Ile Ile Leu Ile Ser
  65                  70                  75                  80
 Cys Glu Asn Asp Leu His Leu Cys Arg Glu Tyr Phe Ala Arg Gly Ile
                  85                  90                  95    
 Gly Thr Phe Pro Arg Leu Pro Val
             100                



      <210> 664
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 664
 Ala Ser Leu Ser Cys Gly Gly Leu His Pro Val Arg Ala Ser Trp Leu
   1               5                  10                  15    
 Leu Cys Leu Thr Lys Gln Ala Trp Ala Met Glu Gly Ala Pro Pro Pro
              20                  25                  30        
 Ala Ser Leu Pro Pro Cys Ser Leu Ile Ser Asp Cys Cys Ala Ser Asn
          35                  40                  45            
 Gln Arg Asp Ser Val Gly Val Gly Pro Ser Glu Pro Cys Ala Gly Tyr
      50                  55                  60                
 Asn Leu Val Val Arg Arg Phe Leu Ser Arg Ser Glu Lys Arg Asn Ile
  65                  70                  75                  80
 Arg Val Gly Val Thr Arg Phe Ser Arg Cys Val Leu Ser Pro Leu Ser
                  85                  90                  95    
 Leu Thr Gln Lys Gly Asn Ser Leu Thr Pro Cys Ala Ser Gln Ala Arg
             100                 105                 110        
 Gln Cys Leu Ala Leu Leu Arg Leu Ala His Gly Ala Arg Thr His
         115                 120                 125        



      <210> 665
      <211> 126
      <212> PRT
      <213> Homo sapiens


      <400> 665
 Gly Arg Val Arg Leu Leu Asn Asn Trp Asp Val Cys Ala Asn Met Phe
   1               5                  10                  15    
 Gly Thr Phe Phe Asp Thr Glu Asp Pro Gly Glu Phe Lys Met Lys Tyr
              20                  25                  30        
 Trp Gly Val Thr Ser Phe Leu Gln Lys Gly Asn Asp Asp His Trp Ile
          35                  40                  45            
 Val Asp Thr Asp Tyr Asp Thr Tyr Ala Gly Gln Tyr Ser Cys Arg Leu
      50                  55                  60                
 Leu Asn Leu Asp Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser
  65                  70                  75                  80
 Arg Asp Pro Asn Gly Leu Pro Pro Glu Ala Gln Lys Ile Val Arg Gln
                  85                  90                  95    
 Arg Gln Glu Glu Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile Val His
             100                 105                 110        
 Asn Gly Tyr Cys Asp Gly Arg Ser Lys Arg Asn Leu Leu
         115                 120                 125



      <210> 666
      <211> 35
      <212> PRT
      <213> Homo sapiens


      <400> 666
 Gln Ala Gly Leu Glu Leu Leu Thr Ser Asp Asp Leu Pro Ala Ser Ala
   1               5                  10                  15    
 Ser Lys Ser Ala Gly Thr Thr Gly Val Ser His Arg Ala Arg Pro Thr
              20                  25                  30        
 Leu Val Phe
          35



      <210> 667
      <211> 38
      <212> PRT
      <213> Homo sapiens


      <400> 667
 Gly Asn Val Leu Pro Val Leu Tyr Gly Glu Met Arg Val Gly Ser Arg
   1               5                  10                  15    
 Val Val Ser Gln Glu Ile Ser Thr Ala Asp Glu Gly Asp Gly Gly Gln
              20                  25                  30        
 Val Val Val Ile Gly Arg
          35            



      <210> 668
      <211> 111
      <212> PRT
      <213> Homo sapiens


      <400> 668
 Thr Glu Gln Lys Ser Lys Ser Lys Gln His Arg Val Ser Arg Arg Ala
   1               5                  10                  15    
 Gln Gln Arg Ala Glu Ser Pro Glu Ser Ser Ala Ile Glu Ser Thr Gln
              20                  25                  30        
 Ser Thr Pro Gln Lys Gly Arg Gly Arg Pro Ser Lys Thr Pro Ser Pro
          35                  40                  45            
 Ser Gln Pro Lys Lys Asn Val Arg Val Gly Arg Ser Lys Gln Ala Ala
      50                  55                  60                
 Thr Lys Glu Asn Asp Ser Ser Glu Glu Val Asn Val Phe Gln Gly Ser
  65                  70                  75                  80
 Ser Pro Val Asp Asp Ile Pro Gln Glu Glu Thr Glu Glu Glu Glu Val
                  85                  90                  95    
 Ser Thr Val Asn Val Arg Arg Arg Ser Ala Lys Arg Glu Arg Arg
             100                 105                 110    



      <210> 669
      <211> 39
      <212> PRT
      <213> Homo sapiens


      <400> 669
 Asn Tyr Arg Arg Arg Pro Arg Pro Pro Asn Ala Pro Ser Gln Asp Gly
   1               5                  10                  15    
 Lys Glu Ala Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala Pro Pro
              20                  25                  30        
 Thr Gln Gln Ser Ser Ala Glu
          35                



      <210> 670
      <211> 39
      <212> PRT
      <213> Homo sapiens


      <400> 670
 Asn Tyr Arg Arg Arg Pro Arg Pro Pro Asn Ala Pro Ser Gln Asp Gly
   1               5                  10                  15    
 Lys Glu Ala Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala Pro Pro
              20                  25                  30        
 Thr Gln Gln Ser Ser Ala Glu
          35                



      <210> 671
      <211> 93
      <212> PRT
      <213> Homo sapiens


      <400> 671
 Lys Thr Glu Asn Asp His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly
   1               5                  10                  15    
 Ser Leu Val Gln Phe Lys Ile Lys Arg Arg Thr Pro Leu Ser Lys Leu
              20                  25                  30        
 Met Lys Ala Tyr Cys Glu Arg Gln Gly Leu Ser Met Arg His Ile Thr
          35                  40                  45            
 Leu Arg Phe Asp Gly Gln Ser Ile Asn Glu Thr Asp Thr Pro Ala Gln
      50                  55                  60                
 Leu Glu Met Glu Asp Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr
  65                  70                  75                  80
 Glu Ser Val Pro Asp Ser Ile Leu Ala Gly His Ser Phe
                  85                  90            



      <210> 672
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 672
 Glu Arg Val Leu Glu Asn Val Glu His Tyr Gln Glu Leu Lys Lys Met
   1               5                  10                  15    
 Val Gln Gln Ser Asp Leu Gly Gln Tyr Val Thr Phe Leu Arg Ser Phe
              20                  25                  30        
 Ser Asp Lys Gln Lys Ile Ser Leu Leu His Ser Cys Thr Cys Val Leu
          35                  40                  45            
 Tyr Thr Pro Ser Asn Glu His Phe Gly Ile Val Pro Leu Glu Ala Met
      50                  55                  60                
 Tyr Met Gln Cys Pro Val Ile Ala Val Asn Ser Gly Gly Pro Leu Glu
  65                  70                  75                  80
 Ser Ile Asp His Ser Val Thr Gly Phe Leu Cys Glu Pro Asp Pro Val
                  85                  90                  95    
 His Phe Ser Glu Ala Ile Glu Lys Phe Ile Arg Glu Pro Ser Leu Lys
             100                 105                 110        
 Ala Thr Met Gly Leu Ala Gly Arg Ala Arg Val Lys Glu Lys Phe Ser
         115                 120                 125            
 Pro Glu Ala Phe Thr Glu Gln Leu Tyr Arg Tyr Val Thr Lys Leu Ala
     130                 135                 140                
 Gly
 145



      <210> 673
      <211> 210
      <212> PRT
      <213> Homo sapiens


      <400> 673
 Lys Ala Asp Phe Met Arg Pro Arg Ile Ser Phe Val Asp Arg Cys Tyr
   1               5                  10                  15    
 Ile Phe Ser Met Leu Asp Asn Glu Val Gly Ala Asn Pro Arg Gly Gly
              20                  25                  30        
 His Gln Cys Gly Ser Ala Leu Ser Cys Asp Glu Gly Val Pro Ala Ala
          35                  40                  45            
 Gln Gly Ala Ser Ser Glu Lys Pro His Glu Cys Thr Lys Cys Gly Lys
      50                  55                  60                
 Ala Leu Cys Cys Arg Ser Asp Leu Arg Val His His Gly Val His Ala
  65                  70                  75                  80
 Gly Glu Lys Ser Ser Ala Cys Ser Glu Arg Gly Ser Gly Phe Arg Glu
                  85                  90                  95    
 Lys Leu Cys Pro Asp Lys Gln Gly Thr His Thr Lys Glu Lys Pro Ala
             100                 105                 110        
 Arg Asp Ser Arg Ser Gly Lys Thr Ile Phe Arg Lys Thr Arg Leu Cys
         115                 120                 125            
 Val Pro Gly Thr Val His Ala Gly Ala Lys Pro Tyr Lys Cys Trp Glu
     130                 135                 140                
 Cys Glu Lys Thr Ser His Lys Ser Arg Leu Ile Glu His Leu Arg Ser
 145                 150                 155                 160
 His Thr Gly Glu Lys Pro Cys Gly Cys Arg Glu Cys Gly Lys Ala Phe
                 165                 170                 175    
 Phe Gln Lys Ser His Leu Ile Leu Arg Gln Arg Thr His Thr Gly Glu
             180                 185                 190        
 Lys Pro Cys Gly Cys Ala Glu Cys Gly Lys Ala Ala Pro Arg Thr Pro
         195                 200                 205            
 Ala Ser
     210



      <210> 674
      <211> 79
      <212> PRT
      <213> Homo sapiens


      <400> 674
 Val Trp Pro Leu Pro Cys Arg Asp Ala Asp Ala Gln Ser Glu Gly Ile
   1               5                  10                  15    
 Asn Ala Ser Ala Arg Tyr Pro Lys Asn Trp Val Thr Thr Gly Asp Pro
              20                  25                  30        
 Ala Arg Glu Phe Thr Met Ile His Ser Ala Pro Leu Met Leu Leu Ala
          35                  40                  45            
 Asp Pro Asp Glu Phe Glu Ser Val Gln Leu Ala Gln Ser Trp Pro Leu
      50                  55                  60                
 Gly Ala Ile Val Ser Leu Trp Arg Ser Pro Cys Arg Lys Met Asn
  65                  70                  75                



      <210> 675
      <211> 149
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(148)
      <223> Xaa = any amino acid or nothing 


      <400> 675
 Arg Gly Ile Asn Ile Asn Lys Lys Asp Val His Thr Glu Thr Pro Cys
   1               5                  10                  15    
 Lys Gly His Gln His Gln Arg Pro Lys Val Asp Lys Ser Met Lys Met
              20                  25                  30        
 Arg Lys Ser Xaa Cys Lys Lys Ala Glu Asn Ser Lys Asn Gln Asn Gly
          35                  40                  45            
 Ser Ser Pro Ala Lys Asp Tyr Asn Ser Ser Pro Ala Arg Glu Gln Asn
      50                  55                  60                
 Trp Met Glu Asn Trp Leu Asp Lys Leu Thr Glu Val Gly Phe Ile Arg
  65                  70                  75                  80
 Trp Ile Ile Thr Asn Ser Phe Lys Leu Lys Glu His Val Leu Thr Gln
                  85                  90                  95    
 Cys Lys Glu Leu Arg Ser Phe Glu Lys Lys Leu Glu Glu Leu Leu Thr
             100                 105                 110        
 Lys Ile Ile Ser Leu Glu Lys Thr Ile Ser Val Xaa Gly Glu Gly Xaa
         115                 120                 125            
 Ile Gln Ile Leu Asp Arg Ser Leu Xaa Arg Val Cys Val Gly Tyr Leu
     130                 135                 140                
 Arg Arg Ser Cys
 145            



      <210> 676
      <211> 135
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(135)
      <223> Xaa = any amino acid or nothing 


      <400> 676
 Ala Ala Ala Ala Ala Ala Asp Met Glu Arg Gln Glu Glu Ser Leu Ser
   1               5                  10                  15    
 Ala Arg Pro Ala Leu Glu Thr Glu Gly Leu Arg Phe Leu His Thr Thr
              20                  25                  30        
 Glu Gly Ser Leu Leu Ala Thr Tyr Gly Trp Asn Ile Val Phe Ser Cys
          35                  40                  45            
 Ile Leu Leu Tyr Val Val Phe Gln Lys Leu Ser Ala Arg Leu Arg Ala
      50                  55                  60                
 Leu Arg His Arg Gln Leu Asp Arg Ala Ala Ala Ala Val Glu Pro Asp
  65                  70                  75                  80
 Val Asp Val Lys Leu Gln Glu Ala Leu Ala Ala Ala Arg Leu Lys Met
                  85                  90                  95    
 Gln Glu Glu Leu Asn Ala Gln Val Glu Lys His Lys Glu Lys Leu Lys
             100                 105                 110        
 Gln Leu Glu Xaa Glu Lys Arg Arg Gln Thr Ile Glu Met Trp Asp Ser
         115                 120                 125            
 Met Gln Asp Gly Lys Ser Tyr
     130                 135



      <210> 677
      <211> 194
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(194)
      <223> Xaa = any amino acid or nothing 


      <400> 677
 Gly Gly Trp Leu Ala Phe Pro Leu Ala Cys Pro Gly Arg Cys His Gln
   1               5                  10                  15    
 Pro Pro Ala Ala Tyr Ala Ser Ala Ala Leu Leu Asn Leu Gly Arg Pro
              20                  25                  30        
 Glu Ala Pro Ala His Pro Gln Thr Ala Gly Ser Val Arg Pro Ala Ala
          35                  40                  45            
 Val Pro Pro Gly Cys Xaa Gly Arg Thr Gly Gly Ala Gly Ser Pro Ala
      50                  55                  60                
 Gly His Ser Ala Thr Gly Pro Ala Ala Pro Pro Pro Arg Gly Ser Thr
  65                  70                  75                  80
 Ser Ser Ala Pro Pro Ala Arg Gln Ala Glu Ala Gly Leu Glu Ser Ser
                  85                  90                  95    
 Ser Ala Gln Val Ile Arg Pro Pro Arg Ser Ser Lys Val Leu Gly Leu
             100                 105                 110        
 Gln Ala Xaa Ala Thr Ala Pro Gly Leu Pro Gln Leu Ser Glu Gly Asp
         115                 120                 125            
 Pro Gly Phe Pro Ser Gly Arg Val Thr Trp Ile Gly Gln Ser Pro Ala
     130                 135                 140                
 Ser Glu Asp Ser Trp Arg Pro Ser Ala Val Ser Ser Leu Thr Tyr Ser
 145                 150                 155                 160
 Pro Val Ser Pro Ala Arg Gly Cys Arg Ser Pro Ser Xaa Lys Ser Gly
                 165                 170                 175    
 Lys Thr Xaa Lys Ser Arg Gln Pro Lys Arg Glu Asn Pro Pro Gly Thr
             180                 185                 190        
 Ala Pro
        



      <210> 678
      <211> 72
      <212> PRT
      <213> Homo sapiens


      <400> 678
 Ile Leu Lys Ala Gln Ala Thr Val Gly Ile Ser Ile Asn Leu Asp Ser
   1               5                  10                  15    
 Pro Phe Thr Ser Pro Pro Leu Arg Glu Glu Ile Met Ala Asn Asn Phe
              20                  25                  30        
 Ser Leu Glu Ser His Asn Ile Ser Leu Thr Glu His Ser Ser Met Pro
          35                  40                  45            
 Val Glu Asn Asn Ile Thr Leu Glu Arg Pro Ser Asn Val Asn Leu Thr
      50                  55                  60                
 Cys Gln Phe Thr Thr Ser Gly Asp
  65                  70        



      <210> 679
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 679
 Gly Asn Met Lys Lys Gln Gly Ile Ser Asn Phe Ile Ser Tyr Ile Tyr
   1               5                  10                  15    
 Thr His Thr His Thr His Thr His Thr His Thr Tyr Ile Tyr Ile Tyr
              20                  25                  30        
 Ile His Ile Tyr Thr Tyr Thr His Thr Tyr Asn Phe Phe Phe Leu Glu
          35                  40                  45            
 Arg Glu Leu His Ser
      50            



      <210> 680
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 680
 Arg Arg Pro Glu Cys Val Trp Gly Arg Arg Gly Pro Ala Gly Glu Glu
   1               5                  10                  15    
 Ser Glu Gln Thr Ala Leu Ile Pro Leu Pro Arg Gly Leu Leu Thr Pro
              20                  25                  30        
 Pro Asn Trp Ser Gly Pro Pro Gly Leu Pro Pro Ala Ala Ser Gln Pro
          35                  40                  45            
 Ile Ile Leu Pro Gly Pro Gly Pro Ser Pro Asn Leu Leu Lys Ser Ser
      50                  55                  60                
 Thr Ser Ser Glu Arg Ser Arg Gly Ala Lys
  65                  70                



      <210> 681
      <211> 258
      <212> PRT
      <213> Homo sapiens


      <400> 681
 Pro Trp Val Leu Thr Met Asn Phe Ser Gly Gly Gly Arg Gln Glu Ala
   1               5                  10                  15    
 Ala Gly Ser Arg Gly Arg Arg Ala Pro Arg Pro Arg Glu Gln Asp Arg
              20                  25                  30        
 Asp Val Gln Leu Ser Lys Ala Leu Ser Tyr Ala Leu Arg His Gly Ala
          35                  40                  45            
 Leu Lys Leu Gly Leu Pro Met Gly Ala Asp Gly Phe Val Pro Leu Gly
      50                  55                  60                
 Thr Leu Leu Gln Leu Pro Gln Phe Arg Gly Phe Ser Ala Glu Asp Val
  65                  70                  75                  80
 Gln Arg Val Val Asp Thr Asn Arg Lys Gln Arg Phe Ala Leu Gln Leu
                  85                  90                  95    
 Gly Asp Pro Ser Thr Gly Leu Leu Ile Arg Ala Asn Gln Gly His Ser
             100                 105                 110        
 Leu Gln Val Pro Lys Leu Glu Leu Met Pro Leu Glu Thr Pro Gln Ala
         115                 120                 125            
 Leu Pro Pro Met Leu Val His Gly Thr Phe Trp Lys His Trp Pro Ser
     130                 135                 140                
 Ile Leu Leu Lys Gly Leu Ser Cys Gln Gly Arg Thr His Ile His Leu
 145                 150                 155                 160
 Ala Pro Gly Leu Pro Gly Asp Pro Gly Ile Ile Ser Gly Met Arg Ser
                 165                 170                 175    
 Arg Cys Glu Ile Ala Val Phe Ile Asp Gly Pro Leu Ala Leu Ala Asp
             180                 185                 190        
 Gly Ile Pro Phe Phe Arg Ser Ala Asn Gly Val Ile Leu Thr Pro Gly
         195                 200                 205            
 Asn Thr Asp Gly Phe Leu Leu Pro Lys Tyr Phe Lys Glu Ala Leu Gln
     210                 215                 220                
 Leu Arg Pro Thr Arg Lys Pro Leu Ser Leu Ala Gly Asp Glu Glu Thr
 225                 230                 235                 240
 Glu Cys Gln Ser Ser Pro Lys His Ser Ser Arg Glu Arg Arg Arg Ile
                 245                 250                 255    
 Gln Gln
        



      <210> 682
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 682
 Phe Asp Gln Pro Pro Gly Leu Lys Ala Thr Arg Asp Glu Lys Asp Ser
   1               5                  10                  15    
 Leu Leu Asn Ile Ala Arg Gly Lys Lys Asn Gly Glu Lys Thr Arg Arg
              20                  25                  30        
 Val Ser Ser Arg Lys Lys Pro Ala Leu Lys Ala Thr Ser Asp Glu Lys
          35                  40                  45            
 Asp Ser Phe Ser Asn Ile Thr Arg Gly Lys Lys Asp Gly Glu Ile Ser
      50                  55                  60                
 Arg Lys Val Ser Ser Gln Lys Pro Pro Thr Leu Lys Gly Thr Ser Asp
  65                  70                  75                  80
 Glu Glu Asp Ser Val Leu Gly Ile Ala Arg Glu Asn Lys Asp Gly Glu
                  85                  90                  95    
 Lys Ser Arg Thr Val Ser Ser Glu Lys Pro Pro Gly Leu Lys Ala Ser
             100                 105                 110        
 Ser Asp Glu Lys Glu Asn Val Leu Asn Ile Ala Arg Val Tyr Cys Val
         115                 120                 125            
 Arg Cys Arg Gly Ser
     130            



      <210> 683
      <211> 384
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(382)
      <223> Xaa = any amino acid or nothing 


      <400> 683
 Glu Ala Leu His Leu Ala His Phe Gly Leu Thr Gly Phe Thr Gln Thr
   1               5                  10                  15    
 His Cys Ala Arg Ala Trp Gly Gly Gln Thr Arg Lys Arg Arg Arg Val
              20                  25                  30        
 Pro Arg Asp Pro Gly Gly Ala Asn Cys Ala Gly Gly Gly Val Ser Ala
          35                  40                  45            
 Asp Thr Ser Gly Leu Ala Ala Ala Ala Arg Gly Pro Pro Thr Leu Gly
      50                  55                  60                
 Phe Arg Glu Arg Arg Ser Ala Arg Ser Leu Asp Arg Ile Arg Pro Ile
  65                  70                  75                  80
 Leu Val Leu Met Val Asp Lys Lys Leu Val Val Val Phe Gly Gly Thr
                  85                  90                  95    
 Gly Ala Gln Gly Gly Ser Val Ala Arg Thr Leu Leu Glu Asp Gly Thr
             100                 105                 110        
 Phe Lys Val Arg Val Val Thr Arg Asn Pro Arg Lys Lys Ala Ala Lys
         115                 120                 125            
 Glu Leu Arg Leu Gln Gly Ala Glu Val Val Gln Gly Asp Gln Asp Asp
     130                 135                 140                
 Gln Val Ile Met Glu Leu Ala Leu Asn Gly Ala Tyr Ala Thr Phe Ile
 145                 150                 155                 160
 Val Thr Asn Tyr Trp Glu Ser Cys Ser Gln Glu Gln Glu Val Lys Gln
                 165                 170                 175    
 Gly Lys Leu Leu Ala Asp Leu Ala Arg Arg Leu Gly Leu His Tyr Val
             180                 185                 190        
 Val Tyr Ser Gly Leu Glu Asn Ile Lys Lys Leu Thr Ala Gly Arg Leu
         195                 200                 205            
 Ala Ala Ala His Phe Asp Gly Lys Gly Glu Val Glu Glu Tyr Phe Arg
     210                 215                 220                
 Asp Ile Gly Val Pro Met Thr Ser Val Arg Leu Pro Cys Tyr Phe Glu
 225                 230                 235                 240
 Asn Leu Leu Ser His Phe Leu Pro Gln Lys Ala Pro Asp Gly Lys Ser
                 245                 250                 255    
 Tyr Leu Leu Ser Leu Pro Thr Gly Asp Val Pro Met Asp Gly Met Ser
             260                 265                 270        
 Val Ser Asp Leu Gly Pro Val Val Leu Ser Leu Leu Lys Met Pro Glu
         275                 280                 285            
 Lys Tyr Val Gly Gln Asn Ile Gly Leu Ser Thr Cys Arg His Thr Ala
     290                 295                 300                
 Glu Glu Tyr Ala Ala Leu Leu Thr Lys His Pro Ala Arg Ser Cys Thr
 305                 310                 315                 320
 Met Pro Arg Xaa Leu Leu Arg Thr Thr Lys Ser Leu Ala Phe Pro Val
                 325                 330                 335    
 Pro Gly Thr Trp Leu Asn Met Phe Arg Phe Tyr Ala Leu Arg Pro Asp
             340                 345                 350        
 Arg Asp Ile Glu Leu Thr Leu Arg Leu Asn Pro Lys Ala Leu Thr Leu
         355                 360                 365            
 Asp Gln Trp Leu Glu Gln His Lys Gly Asp Phe Asn Leu Leu
     370                 375                 380        



      <210> 684
      <211> 737
      <212> PRT
      <213> Homo sapiens


      <400> 684
 Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys
   1               5                  10                  15    
 Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro
              20                  25                  30        
 Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val
          35                  40                  45            
 Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu
      50                  55                  60                
 His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala
  65                  70                  75                  80
 Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val
                  85                  90                  95    
 Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr
             100                 105                 110        
 Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe
         115                 120                 125            
 Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val
     130                 135                 140                
 Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu
 145                 150                 155                 160
 Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile
                 165                 170                 175    
 His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala
             180                 185                 190        
 Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala
         195                 200                 205            
 Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln
     210                 215                 220                
 Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala
 225                 230                 235                 240
 Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser
                 245                 250                 255    
 Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro
             260                 265                 270        
 Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His
         275                 280                 285            
 Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr
     290                 295                 300                
 Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys
 305                 310                 315                 320
 Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly
                 325                 330                 335    
 Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp
             340                 345                 350        
 Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn
         355                 360                 365            
 Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala
     370                 375                 380                
 Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln
 385                 390                 395                 400
 Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr
                 405                 410                 415    
 Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr
             420                 425                 430        
 Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala
         435                 440                 445            
 Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln
     450                 455                 460                
 Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln
 465                 470                 475                 480
 Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met
                 485                 490                 495    
 Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro
             500                 505                 510        
 Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr
         515                 520                 525            
 Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp
     530                 535                 540                
 Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr
 545                 550                 555                 560
 Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val
                 565                 570                 575    
 Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly
             580                 585                 590        
 Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg
         595                 600                 605            
 Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys
     610                 615                 620                
 Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu
 625                 630                 635                 640
 Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp
                 645                 650                 655    
 Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys
             660                 665                 670        
 Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala
         675                 680                 685            
 Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu
     690                 695                 700                
 Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp
 705                 710                 715                 720
 Ser Val Gly Pro Leu Gly Thr Gly Pro Met Ala Gly Ala Gly Leu Pro
                 725                 730                 735    





      <210> 685
      <211> 70
      <212> PRT
      <213> Homo sapiens

      <221> misc_feature
      <222> (1)...(70)
      <223> Xaa = any amino acid or nothing 


      <400> 685
 Asn Cys Phe Leu Val Phe Ser Pro Ala Arg Ser Thr Val Gly Glu Phe
   1               5                  10                  15    
 Ala Ser Met Ser Ser Glu Glu Cys Ile Xaa Met His Val Val Phe Leu
              20                  25                  30        
 Phe Pro Leu Thr Leu Cys Val Val Ser Leu Xaa Glu Arg Gln Glu Ala
          35                  40                  45            
 Glu Lys Met Phe Lys Gly Lys Arg Gly Ala Gln Leu Ala Lys Asp Ile
      50                  55                  60                
 Ala Arg Arg Ser Lys Thr
  65                  70



      <210> 686
      <211> 453
      <212> PRT
      <213> Homo sapiens


      <400> 686
 Gln Ala Gln Pro Met Gly Arg Val Gly Gly Met Ala Gln Pro Met Gly
   1               5                  10                  15    
 Arg Ala Gly Ala Pro Lys Pro Met Gly Arg Ala Gly Ser Ala Arg Arg
              20                  25                  30        
 Gly Arg Phe Lys Gly Cys Trp Ser Glu Gly Ser Pro Val His Pro Val
          35                  40                  45            
 Pro Ala Val Leu Ser Trp Leu Leu Ala Leu Leu Arg Cys Ala Ser Thr
      50                  55                  60                
 Met Leu Ser Leu Arg Val Pro Leu Ala Pro Ile Thr Asp Pro Gln Gln
  65                  70                  75                  80
 Leu Gln Leu Ser Pro Leu Lys Gly Leu Ser Leu Val Asp Lys Glu Asn
                  85                  90                  95    
 Thr Pro Pro Ala Leu Ser Gly Thr Arg Val Leu Ala Ser Lys Thr Ala
             100                 105                 110        
 Arg Arg Ile Phe Gln Glu Pro Thr Glu Pro Lys Thr Lys Ala Ala Ala
         115                 120                 125            
 Pro Gly Val Glu Asp Glu Pro Leu Leu Arg Glu Asn Pro Arg Arg Phe
     130                 135                 140                
 Val Ile Phe Pro Ile Glu Tyr His Asp Ile Trp Gln Met Tyr Lys Lys
 145                 150                 155                 160
 Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Lys Asp
                 165                 170                 175    
 Ile Gln His Trp Glu Ser Leu Lys Pro Glu Glu Arg Tyr Phe Ile Ser
             180                 185                 190        
 His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Asn Glu Asn
         195                 200                 205            
 Leu Val Glu Arg Phe Ser Gln Glu Val Gln Ile Thr Glu Ala Arg Cys
     210                 215                 220                
 Phe Tyr Gly Phe Gln Ile Ala Met Glu Asn Ile His Ser Glu Met Tyr
 225                 230                 235                 240
 Ser Leu Leu Ile Asp Thr Tyr Ile Lys Asp Pro Lys Glu Arg Glu Phe
                 245                 250                 255    
 Leu Phe Asn Ala Ile Glu Thr Met Pro Cys Val Lys Lys Lys Ala Asp
             260                 265                 270        
 Trp Ala Leu Arg Trp Ile Gly Asp Lys Glu Ala Thr Tyr Gly Glu Arg
         275                 280                 285            
 Val Val Ala Phe Ala Ala Val Glu Gly Ile Phe Phe Ser Gly Ser Phe
     290                 295                 300                
 Ala Ser Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr
 305                 310                 315                 320
 Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe
                 325                 330                 335    
 Ala Cys Leu Met Phe Lys His Leu Val His Lys Pro Ser Glu Glu Arg
             340                 345                 350        
 Val Arg Glu Ile Ile Ile Asn Ala Val Arg Ile Glu Gln Glu Phe Leu
         355                 360                 365            
 Thr Glu Ala Leu Pro Val Lys Leu Ile Gly Met Asn Cys Thr Leu Met
     370                 375                 380                
 Lys Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Met Leu Glu Leu Gly
 385                 390                 395                 400
 Phe Ser Lys Val Phe Arg Val Glu Asn Pro Phe Asp Phe Met Glu Asn
                 405                 410                 415    
 Ile Ser Leu Glu Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu
             420                 425                 430        
 Tyr Gln Arg Met Gly Val Met Ser Ser Pro Thr Glu Asn Ser Phe Thr
         435                 440                 445            
 Leu Asp Ala Asp Phe
     450            



      <210> 687
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 687
 Arg Asn Met Ala Ala Ala Thr Leu Thr Ser Lys Leu Tyr Ser Leu Leu
   1               5                  10                  15    
 Phe Arg Arg Thr Ser Thr Phe Ala Leu Thr Ile Ile Val Gly Val Met
              20                  25                  30        
 Phe Phe Glu Arg Ala Phe Asp Gln Gly Ala Asp Ala Ile Tyr Asp His
          35                  40                  45            
 Val Asn Glu Gly Lys Leu Trp Lys His Ile Lys His Lys Tyr Glu Asn
      50                  55                  60                
 Lys
  65



      <210> 688
      <211> 344
      <212> PRT
      <213> Homo sapiens


      <400> 688
 Gln Trp Arg Asn Ser Ser His Arg Cys Leu Leu Leu His Pro Pro Leu
   1               5                  10                  15    
 Arg Arg Leu Pro Pro Ala Leu Pro Pro Pro Pro Pro Pro Cys Cys Cys
              20                  25                  30        
 Ser Lys Leu Leu Pro Pro Leu Gly Leu Lys Gly Phe Gln Met Glu His
          35                  40                  45            
 Phe Asp Ala Ser Leu Ser Thr Tyr Phe Lys Ala Leu Leu Gly Pro Arg
      50                  55                  60                
 Asp Thr Arg Val Lys Gly Trp Phe Leu Leu Asp Asn Tyr Ile Pro Thr
  65                  70                  75                  80
 Phe Ile Cys Ser Val Ile Tyr Leu Leu Ile Val Trp Leu Gly Pro Lys
                  85                  90                  95    
 Tyr Met Arg Asn Lys Gln Pro Phe Ser Cys Arg Gly Ile Leu Val Val
             100                 105                 110        
 Tyr Asn Leu Gly Leu Thr Leu Leu Ser Leu Tyr Met Phe Cys Glu Leu
         115                 120                 125            
 Val Thr Gly Val Trp Glu Gly Lys Tyr Asn Phe Phe Cys Gln Gly Thr
     130                 135                 140                
 Arg Thr Ala Gly Glu Ser Asp Met Lys Ile Ile Arg Val Leu Trp Trp
 145                 150                 155                 160
 Tyr Tyr Phe Ser Lys Leu Ile Glu Phe Met Asp Thr Phe Phe Phe Ile
                 165                 170                 175    
 Leu Arg Lys Asn Asn His Gln Ile Thr Val Leu His Val Tyr His His
             180                 185                 190        
 Ala Ser Met Leu Asn Ile Trp Trp Phe Val Met Asn Trp Val Pro Cys
         195                 200                 205            
 Gly His Ser Tyr Phe Gly Ala Thr Leu Asn Ser Phe Ile His Val Leu
     210                 215                 220                
 Met Tyr Ser Tyr Tyr Gly Leu Ser Ser Val Pro Ser Met Arg Pro Tyr
 225                 230                 235                 240
 Leu Trp Trp Lys Lys Tyr Ile Thr Gln Gly Gln Leu Leu Gln Phe Val
                 245                 250                 255    
 Leu Thr Ile Ile Gln Thr Ser Cys Gly Val Ile Trp Pro Cys Thr Phe
             260                 265                 270        
 Pro Leu Gly Trp Leu Tyr Phe Gln Ile Gly Tyr Met Ile Ser Leu Ile
         275                 280                 285            
 Ala Leu Phe Thr Asn Phe Tyr Ile Gln Thr Tyr Asn Lys Lys Gly Ala
     290                 295                 300                
 Ser Arg Arg Lys Asp His Leu Lys Asp His Gln Asn Gly Ser Met Ala
 305                 310                 315                 320
 Ala Val Asn Gly His Thr Asn Ser Phe Ser Pro Leu Glu Asn Asn Val
                 325                 330                 335    
 Lys Pro Arg Lys Leu Arg Lys Asp
             340                

