<110> Human Genome Sciences, Inc., et al.

<120> Nucleic Acids, Proteins, and Antibodies

<130> PTZ11PCT

<150> 60/179,065
<151> 2000-01-31

<150> 60/180,628
<151> 2000-02-04

<150> 60/214,886
<151> 2000-06-28

<150> 60/217,487
<151> 2000-07-11

<150> 60/225,758
<151> 2000-08-14

<150> 60/220,963
<151> 2000-07-26

<150> 60/217,496
<151> 2000-07-11

<150> 60/225,447
<151> 2000-08-14

<150> 60/218,290
<151> 2000-07-14

<150> 60/225,757
<151> 2000-08-14

<150> 60/226,868
<151> 2000-08-22

<150> 60/216,647
<151> 2000-07-07

<150> 60/225,267
<151> 2000-08-14

<150> 60/216,880
<151> 2000-07-07

<150> 60/225,270
<151> 2000-08-14

<150> 60/251,869
<151> 2000-12-08

<150> 60/235,834
<151> 2000-09-27

<150> 60/234,274
<151> 2000-09-21

<150> 60/234,223
<151> 2000-09-21

<150> 60/228,924
<151> 2000-08-30

<150> 60/224,518
<151> 2000-08-14

<150> 60/236,369
<151> 2000-09-29

<150> 60/224,519
<151> 2000-08-14

<150> 60/220,964
<151> 2000-07-26

<150> 60/241,809
<151> 2000-10-20

<150> 60/249,299
<151> 2000-11-17

<150> 60/236,327
<151> 2000-09-29

<150> 60/241,785
<151> 2000-10-20

<150> 60/244,617
<151> 2000-11-01

<150> 60/225,268
<151> 2000-08-14

<150> 60/236,368
<151> 2000-09-29

<150> 60/251,856
<151> 2000-12-08

<150> 60/251,868
<151> 2000-12-08

<150> 60/229,344
<151> 2000-09-01

<150> 60/234,997
<151> 2000-09-25

<150> 60/229,343
<151> 2000-09-01

<150> 60/229,345
<151> 2000-09-01

<150> 60/229,287
<151> 2000-09-01

<150> 60/229,513
<151> 2000-09-05

<150> 60/231,413
<151> 2000-09-08

<150> 60/229,509
<151> 2000-09-05

<150> 60/236,367
<151> 2000-09-29

<150> 60/237,039
<151> 2000-10-02

<150> 60/237,038
<151> 2000-10-02

<150> 60/236,370
<151> 2000-09-29

<150> 60/236,802
<151> 2000-10-02

<150> 60/237,037
<151> 2000-10-02

<150> 60/237,040
<151> 2000-10-02

<150> 60/240,960
<151> 2000-10-20

<150> 60/239,935
<151> 2000-10-13

<150> 60/239,937
<151> 2000-10-13

<150> 60/241,787
<151> 2000-10-20

<150> 60/246,474
<151> 2000-11-08

<150> 60/246,532
<151> 2000-11-08

<150> 60/249,216
<151> 2000-11-17

<150> 60/249,210
<151> 2000-11-17

<150> 60/226,681
<151> 2000-08-22

<150> 60/225,759
<151> 2000-08-14

<150> 60/225,213
<151> 2000-08-14

<150> 60/227,182
<151> 2000-08-22

<150> 60/225,214
<151> 2000-08-14

<150> 60/235,836
<151> 2000-09-27

<150> 60/230,438
<151> 2000-09-06

<150> 60/215,135
<151> 2000-06-30

<150> 60/225,266
<151> 2000-08-14

<150> 60/249,218
<151> 2000-11-17

<150> 60/249,208
<151> 2000-11-17

<150> 60/249,213
<151> 2000-11-17

<150> 60/249,212
<151> 2000-11-17

<150> 60/249,207
<151> 2000-11-17

<150> 60/249,245
<151> 2000-11-17

<150> 60/249,244
<151> 2000-11-17

<150> 60/249,217
<151> 2000-11-17

<150> 60/249,211
<151> 2000-11-17

<150> 60/249,215
<151> 2000-11-17

<150> 60/249,264
<151> 2000-11-17

<150> 60/249,214
<151> 2000-11-17

<150> 60/249,297
<151> 2000-11-17

<150> 60/232,400
<151> 2000-09-14

<150> 60/231,242
<151> 2000-09-08

<150> 60/232,081
<151> 2000-09-08

<150> 60/232,080
<151> 2000-09-08

<150> 60/231,414
<151> 2000-09-08

<150> 60/231,244
<151> 2000-09-08

<150> 60/233,064
<151> 2000-09-14

<150> 60/233,063
<151> 2000-09-14

<150> 60/232,397
<151> 2000-09-14

<150> 60/232,399
<151> 2000-09-14

<150> 60/232,401
<151> 2000-09-14

<150> 60/241,808
<151> 2000-10-20

<150> 60/241,826
<151> 2000-10-20

<150> 60/241,786
<151> 2000-10-20

<150> 60/241,221
<151> 2000-10-20

<150> 60/246,475
<151> 2000-11-08

<150> 60/231,243
<151> 2000-09-08

<150> 60/233,065
<151> 2000-09-14

<150> 60/232,398
<151> 2000-09-14

<150> 60/234,998
<151> 2000-09-25

<150> 60/246,477
<151> 2000-11-08

<150> 60/246,528
<151> 2000-11-08

<150> 60/246,525
<151> 2000-11-08

<150> 60/246,476
<151> 2000-11-08

<150> 60/246,526
<151> 2000-11-08

<150> 60/249,209
<151> 2000-11-17

<150> 60/246,527
<151> 2000-11-08

<150> 60/246,523
<151> 2000-11-08

<150> 60/246,524
<151> 2000-11-08

<150> 60/246,478
<151> 2000-11-08

<150> 60/246,609
<151> 2000-11-08

<150> 60/246,613
<151> 2000-11-08

<150> 60/249,300
<151> 2000-11-17

<150> 60/249,265
<151> 2000-11-17

<150> 60/246,610
<151> 2000-11-08

<150> 60/246,611
<151> 2000-11-08

<150> 60/230,437
<151> 2000-09-06

<150> 60/251,990
<151> 2000-12-08

<150> 60/251,988
<151> 2000-12-05

<150> 60/251,030
<151> 2000-12-05

<150> 60/251,479
<151> 2000-12-06

<150> Not assigned
<151> 2000-12-05

<150> Not assigned
<151> 2000-12-01

<150> 60/251,989
<151> 2000-12-08

<150> 60/250,391
<151> 2000-12-01

<150> Not assigned
<151> 2000-12-11

<160> 13

<170> PatentIn Ver. 2.0

<210> 1
<211> 733
<212> DNA
<213> Homo sapiens

<400> 1
gggatccgga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc ccagcacctg     60
aattcgaggg tgcaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga    120
tctcccggac tcctgaggtc acatgcgtgg tggtggacgt aagccacgaa gaccctgagg    180
tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg    240
aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact    300
ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca acccccatcg    360
agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc    420
catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct    480
atccaagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga    540
ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg    600
acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc    660
acaaccacta cacgcagaag agcctctccc tgtctccggg taaatgagtg cgacggccgc    720
gactctagag gat                                                       733

<210> 2
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> Site
<222> (3)
<223> Xaa equals any of the twenty naturally ocurring L-amino acids

<400> 2
Trp Ser Xaa Trp Ser
  1               5

<210> 3
<211> 86
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic sequence with 4 tandem copies of the GAS binding site 
      found in the IRF1 promoter (Rothman et al., Immunity 1:457-468 
      (1994)), 18 nucleotides complementary to the SV40 early promoter,
      and a Xho I restriction site.

<400> 3
gcgcctcgag atttccccga aatctagatt tccccgaaat gatttccccg aaatgatttc     60
cccgaaatat ctgccatctc aattag                                          86

<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic sequence complementary to the SV40 promter; includes a
      Hind III restriction site.

<400> 4
gcggcaagct ttttgcaaag cctaggc                                         27

<210> 5
<211> 271
<212> DNA
<213> Artificial Sequence

<220>
<221> Protein_Bind
<223> Synthetic promoter for use in biological assays; includes GAS
      binding sites found in the IRF1 promoter (Rothman et al., Immunity
      1:457-468 (1994)).

<400> 5
ctcgagattt ccccgaaatc tagatttccc cgaaatgatt tccccgaaat gatttccccg     60 
aaatatctgc catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc    120
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat    180
ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt    240
ttttggaggc ctaggctttt gcaaaaagct t                                   271

<210> 6
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic primer complementary to human genomic EGR-1 promoter
      sequence (Sakamoto et al., Oncogene 6:867-871 (1991)); includes a
      Xho I restriction site.

<400> 6
gcgctcgagg gatgacagcg atagaacccc gg                                   32

<210> 7
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic primer complementary to human genomic EGR-1 promoter
      sequence (Sakamoto et al., Oncogene 6:867-871 (1991)); includes a
      Hind III restriction site.

<400> 7
gcgaagcttc gcgactcccc ggatccgcct c                                    31

<210> 8
<211> 12
<212> DNA
<213> Homo sapiens

<400> 8
ggggactttc cc                                                         12

<210> 9
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic primer with 4 tandem copies of the NF-KB binding site
      (GGGGACTTTCCC), 18 nucleotides complementary to the 5' end of the
      SV40 early promoter sequence, and a XhoI restriction site.

<400> 9
gcggcctcga ggggactttc ccggggactt tccggggact ttccgggact ttccatcctg     60
ccatctcaat tag                                                        73

<210> 10
<211> 256
<212> DNA
<213> Artificial Sequence

<220>
<221> Protein_Bind
<223> Synthetic promoter for use in biological assays; includes NF-KB
      binding sites.

<400> 10
ctcgagggga ctttcccggg gactttccgg ggactttccg ggactttcca tctgccatct     60
caattagtca gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc    120
cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg cagaggccga    180
ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg    240
cttttgcaaa aagctt                                                    256

<210> 11
<211> 1552
<212> DNA
<213> Homo sapiens

<400> 11
ggcacgagcg gctgcgggcg cgaggtgagg ggcgcgaggt tcccagcagg atgccccggc     60
tctgcaggaa gctgaagtga gaggcccgga gagggcccag cccgcccggg gcaggatgac    120
caaggcccgg ctgttccggc tgtggctggt gctggggtcg gtgttcatga tcctgctgat    180
catcgtgtac tgggacagcg caggcgccgc gcacttctac ttgcacacgt ccttctctag    240
gccgcacacg gggccgccgc tgcccacgcc cgggccggac agggacaggg agctcacggc    300
cgactccgat gtcgacgagt ttctggacaa gtttctcagt gctggcgtga agcagagtga    360
ccttcccaga aaggagacgg agcagccgcc tgcgccgggg agcatggagg agagcgtgag    420
aggctacgac tggtccccgc gcgacgcccg gcgcagccca gaccagggcc ggcagcaggc    480
ggagcggagg agcgtgctgc ggggcttctg cgccaactcc agcctggcct tccccaccaa    540
ggagcgcgca ttcgacgaca tccccaactc ggagctgagc cacctgatcg tggacgaccg    600
gcacggggcc atctactgct acgtgcccaa ggtggcctgc accaactgga agcgcgtgat    660
gatcgtgctg agcggaagcc tgctgcaccg cggtgcgccc taccgcgacc cgctgcgcat    720
cccgcgcgag cacgtgcaca acgccagcgc gcacctgacc ttcaacaagt tctggcgccg    780
ctacgggaag ctctcccgcc acctcatgaa ggtcaagctc aagaagtaca ccaagttcct    840
cttcgtgcgc gaccccttcg tgcgcctgat ctccgccttc cgcagcaagt tcgagctgga    900
gaacgaggag ttctaccgca agttcgccgt gcccatgctg cggctgtacg ccaaccacac    960
cagcctgccc gcctcggcgc gcgaggcctt ccgcgctggc ctcaaggtgt ccttcgccaa   1020
cttcatccag tacctgctgg acccgcacac ggagaagctg gcgcccttca acgagcactg   1080
gcggcaggtg taccgcctct gccacccgtg ccagatcgac tacgacttcg tggggaagct   1140
ggagactctg gacgaggacg ccgcgcagct gctgcagcta ctccaggtgg accggcagct   1200
ccgcttcccc ccgagctacc ggaacaggac cgccagcagc tgggaggagg actggttcgc   1260
caagatcccc ctggcctgga ggcagcagct gtataaactc tacgaggccg actttgttct   1320
cttcggctac cccaagcccg aaaacctcct ccgagactga aagctttcgc gttgcttttt   1380
ctcgcgtgcc tggaacctga cgcacgcgca ctccagtttt tttatgacct acgattttgc   1440
aatctgggct tcttgttcac tccactgcct ctatccattg agtactgtat cgatattgtt   1500
ttttaagatt aatatatttc aggtatttaa tacgaaaaaa aaaaaaaaaa aa           1552

<210> 12
<211> 414
<212> PRT
<213> Homo sapiens

<400> 12
Met Thr Lys Ala Arg Leu Phe Arg Leu Trp Leu Val Leu Gly Ser Val
  1               5                  10                  15

Phe Met Ile Leu Leu Ile Ile Val Tyr Trp Asp Ser Ala Gly Ala Ala
             20                  25                  30

His Phe Tyr Leu His Thr Ser Phe Ser Arg Pro His Thr Gly Pro Pro
         35                  40                  45

Leu Pro Thr Pro Gly Pro Asp Arg Asp Arg Glu Leu Thr Ala Asp Ser
     50                  55                  60

Asp Val Asp Glu Phe Leu Asp Lys Phe Leu Ser Ala Gly Val Lys Gln
 65                  70                  75                  80

Ser Asp Leu Pro Arg Lys Glu Thr Glu Gln Pro Pro Ala Pro Gly Ser
                 85                  90                  95

Met Glu Glu Ser Val Arg Gly Tyr Asp Trp Ser Pro Arg Asp Ala Arg
            100                 105                 110

Arg Ser Pro Asp Gln Gly Arg Gln Gln Ala Glu Arg Arg Ser Val Leu
        115                 120                 125

Arg Gly Phe Cys Ala Asn Ser Ser Leu Ala Phe Pro Thr Lys Glu Arg
    130                 135                 140

Ala Phe Asp Asp Ile Pro Asn Ser Glu Leu Ser His Leu Ile Val Asp
145                 150                 155                 160

Asp Arg His Gly Ala Ile Tyr Cys Tyr Val Pro Lys Val Ala Cys Thr
                165                 170                 175

Asn Trp Lys Arg Val Met Ile Val Leu Ser Gly Ser Leu Leu His Arg
            180                 185                 190

Gly Ala Pro Tyr Arg Asp Pro Leu Arg Ile Pro Arg Glu His Val His
        195                 200                 205

Asn Ala Ser Ala His Leu Thr Phe Asn Lys Phe Trp Arg Arg Tyr Gly
    210                 215                 220

Lys Leu Ser Arg His Leu Met Lys Val Lys Leu Lys Lys Tyr Thr Lys
225                 230                 235                 240

Phe Leu Phe Val Arg Asp Pro Phe Val Arg Leu Ile Ser Ala Phe Arg
                245                 250                 255

Ser Lys Phe Glu Leu Glu Asn Glu Glu Phe Tyr Arg Lys Phe Ala Val
            260                 265                 270

Pro Met Leu Arg Leu Tyr Ala Asn His Thr Ser Leu Pro Ala Ser Ala
        275                 280                 285

Arg Glu Ala Phe Arg Ala Gly Leu Lys Val Ser Phe Ala Asn Phe Ile
    290                 295                 300

Gln Tyr Leu Leu Asp Pro His Thr Glu Lys Leu Ala Pro Phe Asn Glu
305                 310                 315                 320

His Trp Arg Gln Val Tyr Arg Leu Cys His Pro Cys Gln Ile Asp Tyr
                325                 330                 335

Asp Phe Val Gly Lys Leu Glu Thr Leu Asp Glu Asp Ala Ala Gln Leu
            340                 345                 350

Leu Gln Leu Leu Gln Val Asp Arg Gln Leu Arg Phe Pro Pro Ser Tyr
        355                 360                 365

Arg Asn Arg Thr Ala Ser Ser Trp Glu Glu Asp Trp Phe Ala Lys Ile
    370                 375                 380

Pro Leu Ala Trp Arg Gln Gln Leu Tyr Lys Leu Tyr Glu Ala Asp Phe
385                 390                 395                 400

Val Leu Phe Gly Tyr Pro Lys Pro Glu Asn Leu Leu Arg Asp 
                405                 410



<210> 13
<211> 2233
<212> DNA
<213> Homo sapiens

<400> 13
caggttccca gcaggatgcc ccggctctgc aggaagctga agtgagaggc ccggagaggg     60
cccagcccgc ccggggcagg atgaccaagg cccggctgtt ccggctgtgg ctggtgctgg    120
ggtcggtgtt catgatcctg ctgatcatcg tgtactggga cagcgcaggc gccgcgcact    180
tctacttgca cacgtccttc tctaggccgc acacggggcc gccgctgccc acgcccgggc    240
cggacaggga cagggagctc acggccgact ccgatgtcga cgagtttctg gacaagtttc    300
tcagtgctgg cgtgaagcag agcgaccttc ccagaaagga gacggagcag ccgcctgcgc    360
cggggagcat ggaggagagc gtgagaggct acgactggtc cccgcgcgac gcccggcgca    420
gcccagacca gggccggcag caggcggagc ggaggagcgt gctgcggggc ttctgcgcca    480
actccagcct ggccttcccc accaaggagc gcgcattcga cgacatcccc aactcggagc    540
tgagccacct gatcgtggac gaccggcacg gggccatcta ctgctacgtg cccaaggtgg    600
cctgcaccaa ctggaagcgc gtgatgatcg tgctgagcgg aagcctgctg caccgcggtg    660
cgccctaccg cgacccgctg cgcatcccgc gcgagcacgt gcacaacgcc agcgcgcacc    720
tgaccttcaa caagttctgg cgccgctacg ggaagctctc ccgccacctc atgaaggtca    780
agctcaagaa gtacaccaag ttcctcttcg tgcgcgaccc cttcgtgcgc ctgatctccg    840
ccttccgcag caagttcgag ctggagaacg aggagttcta ccgcaagttc gccgtgccca    900
tgctgcggct gtacgccaac cacaccagcc tgcccgcctc ggcgcgcgag gccttccgcg    960
ctggcctcaa ggtgtccttc gccaacttca tccagtacct gctggacccg cacacggaga   1020
agctggcgcc cttcaacgag cactggcggc aggtgtaccg cctctgccac ccgtgccaga   1080
tcgactacga cttcgtgggg aagctggaga ctctggacga ggacgccgcg cagctgctgc   1140
agctactcca ggtggaccgg cagctccgct tccccccgag ctaccggaac aggaccgcca   1200
gcagctggga ggaggactgg ttcgccaaga tccccctggc ctggaggcag cagctgtata   1260
aactctacga ggccgacttt gttctcttcg gctaccccaa gcccgaaaac ctcctccgag   1320
actgaaagct ttcgcgttgc tttttctcgc gtgcctggaa cctgacgcac gcgcactcca   1380
gtttttttat gacctacgat tttgcaatct gggcttcttg ttcactccac tgcctctatc   1440
cattgagtac tgtatcgata ttgtttttta agattaatat atttcaggta tttaatacga   1500
aatgtggaag ggaatgctgg agtaaaatat cccctctccc ctccgcccgc ccacccgccc   1560
gcccgctcgc ccgctcgccc gctcctgtgg tttttctgag cgtgcgggcg ccgggagggg   1620
atgctgaggc tgatggagct gcctccaggg ctagggccac tcaccggagg agggcggggc   1680
ctgcacttga agtcaggccg cacctgtctg tttttggaag ggtagccgac aaatccttcc   1740
agagggaaag ttctttgttt aagtgttgta cttgaaaagg tcaatcttca gggcttcctg   1800
tttgaagtca agtcagaggt aaaccggtca gttacagaag caggatttct aggatttcta   1860
actccagctg ttcccatact gtctagttta aattatggct gttaaggccg ggcgggtgac   1920
tcaggcaggt aatcccagaa ctttgggagg cccagacaga aggatcgctt gaggtcagga   1980
atttgagacc tggccaacat ggtgaaaccc tgtctctact aaaaaaaaaa aaaaaaaaaa   2040
aaaaaaaaaa aaaaaaatga gtcgggtgtg gtggtgtgca cctgtagtcc cagctactca   2100
ggagttctga gatggaaaga ttgcttgaac ccaggaggca gaggctgcag tgagctgaga   2160
tcgcgacatt gcactctagc ctgggtgaca gagtgagatt ccatctcaaa ataaataaat   2220
aaatattaat aca                                                      2233


