<110> Human Genome Sciences, Inc., et al.

<120> Nucleic Acids, Proteins, and Antibodies

<130> PTZ01PCT

<150> 60/179,065
<151> 2000-01-31

<150> 60/180,628
<151> 2000-02-04

<150> 60/214,886
<151> 2000-06-28

<150> 60/217,487
<151> 2000-07-11

<150> 60/225,758
<151> 2000-08-14

<150> 60/220,963
<151> 2000-07-26

<150> 60/217,496
<151> 2000-07-11

<150> 60/225,447
<151> 2000-08-14

<150> 60/218,290
<151> 2000-07-14

<150> 60/225,757
<151> 2000-08-14

<150> 60/226,868
<151> 2000-08-22

<150> 60/216,647
<151> 2000-07-07

<150> 60/225,267
<151> 2000-08-14

<150> 60/216,880
<151> 2000-07-07

<150> 60/225,270
<151> 2000-08-14

<150> 60/251,869
<151> 2000-12-08

<150> 60/235,834
<151> 2000-09-27

<150> 60/234,274
<151> 2000-09-21

<150> 60/234,223
<151> 2000-09-21

<150> 60/228,924
<151> 2000-08-30

<150> 60/224,518
<151> 2000-08-14

<150> 60/236,369
<151> 2000-09-29

<150> 60/224,519
<151> 2000-08-14

<150> 60/220,964
<151> 2000-07-26

<150> 60/241,809
<151> 2000-10-20

<150> 60/249,299
<151> 2000-11-17

<150> 60/236,327
<151> 2000-09-29

<150> 60/241,785
<151> 2000-10-20

<150> 60/244,617
<151> 2000-11-01

<150> 60/225,268
<151> 2000-08-14

<150> 60/236,368
<151> 2000-09-29

<150> 60/251,856
<151> 2000-12-08

<150> 60/251,868
<151> 2000-12-08

<150> 60/229,344
<151> 2000-09-01

<150> 60/234,997
<151> 2000-09-25

<150> 60/229,343
<151> 2000-09-01

<150> 60/229,345
<151> 2000-09-01

<150> 60/229,287
<151> 2000-09-01

<150> 60/229,513
<151> 2000-09-05

<150> 60/231,413
<151> 2000-09-08

<150> 60/229,509
<151> 2000-09-05

<150> 60/236,367
<151> 2000-09-29

<150> 60/237,039
<151> 2000-10-02

<150> 60/237,038
<151> 2000-10-02

<150> 60/236,370
<151> 2000-09-29

<150> 60/236,802
<151> 2000-10-02

<150> 60/237,037
<151> 2000-10-02

<150> 60/237,040
<151> 2000-10-02

<150> 60/240,960
<151> 2000-10-20

<150> 60/239,935
<151> 2000-10-13

<150> 60/239,937
<151> 2000-10-13

<150> 60/241,787
<151> 2000-10-20

<150> 60/246,474
<151> 2000-11-08

<150> 60/246,532
<151> 2000-11-08

<150> 60/249,216
<151> 2000-11-17

<150> 60/249,210
<151> 2000-11-17

<150> 60/226,681
<151> 2000-08-22

<150> 60/225,759
<151> 2000-08-14

<150> 60/225,213
<151> 2000-08-14

<150> 60/227,182
<151> 2000-08-22

<150> 60/225,214
<151> 2000-08-14

<150> 60/235,836
<151> 2000-09-27

<150> 60/230,438
<151> 2000-09-06

<150> 60/215,135
<151> 2000-06-30

<150> 60/225,266
<151> 2000-08-14

<150> 60/249,218
<151> 2000-11-17

<150> 60/249,208
<151> 2000-11-17

<150> 60/249,213
<151> 2000-11-17

<150> 60/249,212
<151> 2000-11-17

<150> 60/249,207
<151> 2000-11-17

<150> 60/249,245
<151> 2000-11-17

<150> 60/249,244
<151> 2000-11-17

<150> 60/249,217
<151> 2000-11-17

<150> 60/249,211
<151> 2000-11-17

<150> 60/249,215
<151> 2000-11-17

<150> 60/249,264
<151> 2000-11-17

<150> 60/249,214
<151> 2000-11-17

<150> 60/249,297
<151> 2000-11-17

<150> 60/232,400
<151> 2000-09-14

<150> 60/231,242
<151> 2000-09-08

<150> 60/232,081
<151> 2000-09-08

<150> 60/232,080
<151> 2000-09-08

<150> 60/231,414
<151> 2000-09-08

<150> 60/231,244
<151> 2000-09-08

<150> 60/233,064
<151> 2000-09-14

<150> 60/233,063
<151> 2000-09-14

<150> 60/232,397
<151> 2000-09-14

<150> 60/232,399
<151> 2000-09-14

<150> 60/232,401
<151> 2000-09-14

<150> 60/241,808
<151> 2000-10-20

<150> 60/241,826
<151> 2000-10-20

<150> 60/241,786
<151> 2000-10-20

<150> 60/241,221
<151> 2000-10-20

<150> 60/246,475
<151> 2000-11-08

<150> 60/231,243
<151> 2000-09-08

<150> 60/233,065
<151> 2000-09-14

<150> 60/232,398
<151> 2000-09-14

<150> 60/234,998
<151> 2000-09-25

<150> 60/246,477
<151> 2000-11-08

<150> 60/246,528
<151> 2000-11-08

<150> 60/246,525
<151> 2000-11-08

<150> 60/246,476
<151> 2000-11-08

<150> 60/246,526
<151> 2000-11-08

<150> 60/249,209
<151> 2000-11-17

<150> 60/246,527
<151> 2000-11-08

<150> 60/246,523
<151> 2000-11-08

<150> 60/246,524
<151> 2000-11-08

<150> 60/246,478
<151> 2000-11-08

<150> 60/246,609
<151> 2000-11-08

<150> 60/246,613
<151> 2000-11-08

<150> 60/249,300
<151> 2000-11-17

<150> 60/249,265
<151> 2000-11-17

<150> 60/246,610
<151> 2000-11-08

<150> 60/246,611
<151> 2000-11-08

<150> 60/230,437
<151> 2000-09-06

<150> 60/251,990
<151> 2000-12-08

<150> 60/251,988
<151> 2000-12-05

<150> 60/251,030
<151> 2000-12-05

<150> 60/251,479
<151> 2000-12-06

<150> Not assigned
<151> 2000-12-05

<150> Not assigned
<151> 2000-12-01

<150> 60/251,989
<151> 2000-12-08

<150> 60/250,391
<151> 2000-12-01

<150> Not assigned
<151> 2000-12-11

<160> 18

<170> PatentIn Ver. 2.0

<210> 1
<211> 733
<212> DNA
<213> Homo sapiens

<400> 1
gggatccgga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc ccagcacctg     60
aattcgaggg tgcaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga    120
tctcccggac tcctgaggtc acatgcgtgg tggtggacgt aagccacgaa gaccctgagg    180
tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg    240
aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact    300
ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca acccccatcg    360
agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc    420
catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct    480
atccaagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga    540
ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg    600
acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc    660
acaaccacta cacgcagaag agcctctccc tgtctccggg taaatgagtg cgacggccgc    720
gactctagag gat                                                       733

<210> 2
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> Site
<222> (3)
<223> Xaa equals any of the twenty naturally ocurring L-amino acids

<400> 2
Trp Ser Xaa Trp Ser
  1               5

<210> 3
<211> 86
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic sequence with 4 tandem copies of the GAS binding site 
      found in the IRF1 promoter (Rothman et al., Immunity 1:457-468 
      (1994)), 18 nucleotides complementary to the SV40 early promoter,
      and a Xho I restriction site.

<400> 3
gcgcctcgag atttccccga aatctagatt tccccgaaat gatttccccg aaatgatttc     60
cccgaaatat ctgccatctc aattag                                          86

<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic sequence complementary to the SV40 promter; includes a
      Hind III restriction site.

<400> 4
gcggcaagct ttttgcaaag cctaggc                                         27

<210> 5
<211> 271
<212> DNA
<213> Artificial Sequence

<220>
<221> Protein_Bind
<223> Synthetic promoter for use in biological assays; includes GAS
      binding sites found in the IRF1 promoter (Rothman et al., Immunity
      1:457-468 (1994)).

<400> 5
ctcgagattt ccccgaaatc tagatttccc cgaaatgatt tccccgaaat gatttccccg     60 
aaatatctgc catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc    120
gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat    180
ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt    240
ttttggaggc ctaggctttt gcaaaaagct t                                   271

<210> 6
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic primer complementary to human genomic EGR-1 promoter
      sequence (Sakamoto et al., Oncogene 6:867-871 (1991)); includes a
      Xho I restriction site.

<400> 6
gcgctcgagg gatgacagcg atagaacccc gg                                   32

<210> 7
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic primer complementary to human genomic EGR-1 promoter
      sequence (Sakamoto et al., Oncogene 6:867-871 (1991)); includes a
      Hind III restriction site.

<400> 7
gcgaagcttc gcgactcccc ggatccgcct c                                    31

<210> 8
<211> 12
<212> DNA
<213> Homo sapiens

<400> 8
ggggactttc cc                                                         12

<210> 9
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<221> Primer_Bind
<223> Synthetic primer with 4 tandem copies of the NF-KB binding site
      (GGGGACTTTCCC), 18 nucleotides complementary to the 5' end of the
      SV40 early promoter sequence, and a XhoI restriction site.

<400> 9
gcggcctcga ggggactttc ccggggactt tccggggact ttccgggact ttccatcctg     60
ccatctcaat tag                                                        73

<210> 10
<211> 256
<212> DNA
<213> Artificial Sequence

<220>
<221> Protein_Bind
<223> Synthetic promoter for use in biological assays; includes NF-KB
      binding sites.

<400> 10
ctcgagggga ctttcccggg gactttccgg ggactttccg ggactttcca tctgccatct     60
caattagtca gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc    120
cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg cagaggccga    180
ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg    240
cttttgcaaa aagctt                                                    256

<210> 11
<211> 1066
<212> DNA
<213> Homo sapiens

<220>
<221> SITE
<222> (511)
<223> n equals a,t,g, or c

<400> 11
aattcggcac gagtggacaa ccatcaggga gccaggacac agaggggcag agcaagtcag     60
cattggcgcc ccttcctcag atccctatca tcttgggaaa cagtagccca gaggttcagg    120
aagatgttaa cttaaatgtt cggggtgccc cagtctgttc agcatggctg aaatccacac    180
tccgtattct tccttgaaga aactgttatc tttactcaat ggcttcgtgg ctgtgtctgg    240
catcatccta gttggcctgg gcattggtgg taaatgtgga ggggcctctc tgacgaatgt    300
cctcgggctg tcctccgcat acctccttca cgttggcaac ctgtgcctgg tgatgggatg    360
catcacggta ctgcttggct gtgccgggtg gtatggagcg actaaagaga gcagaggcac    420
gctcttgttt tgcatcctgt caatggttat tgtcctcatc atggaagtta cagctgccac    480
agtggtcctt cttttctttc caattgttgg nagatgtggc cttggaacac accttcgtga    540
ccctgaggaa gaattacaga ggttacaacg agccagacga ctattctaca cagtggaact    600
tggtcatgga gaagctaaag tgctgtgggg tgaataacta cacagatttt tctggctctt    660
ccttcgaaat gacaacgggc cacacctacc ccaggagttg ctgtaaatcc atcggaagtg    720
tgtcctgtga cggacgcgat gtgtctccaa acgtcatcca ccagaagggc tgtttccata    780
aactcctaaa aatcaccaag actcagagct tcaccctgag tgggagctct ctgggagctg    840
cagtgataca gttgccagga attcttgcca ctttgctgct gtttatcaag ctgggctgac    900
acccaggcct ggagaagatg agacacctgg gcccatctgg ctgctggaga ttcagtctca    960
gttttatttc tctgtggcac tcactgcttc tggaggggag actgttaata aaagatttgg   1020
gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa actcga                  1066

<210> 12
<211> 545
<212> DNA
<213> Homo sapiens

<400> 12
ggcacgagct cggccgagcc gggccgcgcc gccgctgccg ccgccgcgcg cggattctgc     60
ttctcagaag atgcactatt atagatactc taacgccaag gtcagctgct ggtacaagta    120
cctccttttc agctacaaca tcatcttctg gttggctgga gttgtcttcc ttggtgtctt    180
aagaaccagc ccacaacagc ctctctttct cctccacata ctgcagcctc cctccatgca    240
tcccacatac aagcactccc ccacttctca tcgttcaggg atggactgca accttaattt    300
acttgccgga gtgtacattc tagtgtggtg tatactggtg gctgttgatg atgatttttt    360
tttttttaca caattctctg tagactagga gaagaatgct tgtgtttttc ggaagtgtga    420
tgcttctctt tgactgccaa actcttttat ggaatatatc ttttttttaa aaaaaaaaaa    480
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    540
aaaaa                                                                545

<210> 13
<211> 770
<212> DNA
<213> Homo sapiens

<220>
<221> SITE
<222> (562)
<223> n equals a,t,g, or c

<220>
<221> SITE
<222> (735)
<223> n equals a,t,g, or c

<220>
<221> SITE
<222> (745)
<223> n equals a,t,g, or c

<400> 13
gcagggagcc aggacacaga ggggcagagc aagtcagcat tggcgcccct tcctcagatc     60
cctatcatct tgggaaacag tagcccagag gttcaggaag atgttaactt aaatgttcgg    120
ggtgccccag tctgttcagc atggctgaaa tccacactcc gtattcttcc ttgaagaaac    180
tgttatcttt actcaatggc wtcgwggctg tgtctggcat catcctagtt ggcctgggca    240
ttggtggtaa atgtggaggg gcctctctga cgaatgtcct cgggctgtcc tccgcatacc    300
tccttcacgt tggcaacctg tgcctggtga tgggatgcat cacggtactg cttggctgtg    360
ccgggtggta tggagcgact aaagagagca gaggcacgct cttgttttgc atcctgtcaa    420
tggttattgt cctcatcatg gaagttacag ctgccacagt ggtccttctt ttctttccaa    480
ttgttggaga tgtggccttg gaacacacct tcgtgaccct gaggaagaat tacagaggtt    540
acaacgagcc agacgactat tntacacagt ggaacttggc atggagaarc taaagtgctt    600
gtggggtgaa taactacaca gatttttctg gctcttcctt caaatkacaa cggccacacc    660
tacccaggag ttsctgtaaa tccawcggaa gtgtgtctgt gacsgacgsg atgtgtttca    720
aacgtcatcc accanaaggc tgttncataa actctaaaaa taccaagact               770

<210> 14
<211> 288
<212> DNA
<213> Homo sapiens

<400> 14
agaaggtgca ctattataga tactctaacg ccaaggtcag ctgctggtac aagtacctcc     60
ttttcagcta caacatcatc ttctggttgg ctggagttgt cttccttggt gtcttaagaa    120
ccagcccaca acagcctctc tttctcctcc acatactgca gcctccctcc atgcatccca    180
catacaagca ctcccccact tctcatcgtt caggatggaa ctgcaacctt aatttacttg    240
ccggagtgta cattctagtg tggtgtatac tggtggctgt tgatgatg                 288

<210> 15
<211> 181
<212> PRT
<213> Homo sapiens

<220>
<221> SITE
<222> (53)
<223> Xaa equals any of the naturally occurring L-amino acids

<400> 15
Trp Asp Ala Ser Arg Tyr Cys Leu Ala Val Pro Gly Gly Met Glu Arg
  1               5                  10                  15

Leu Lys Arg Ala Glu Ala Arg Ser Cys Phe Ala Ser Cys Gln Trp Leu
             20                  25                  30

Leu Ser Ser Ser Trp Lys Leu Gln Leu Pro Gln Trp Ser Phe Phe Ser
         35                  40                  45

Phe Gln Leu Leu Xaa Asp Val Ala Leu Glu His Thr Phe Val Thr Leu
     50                  55                  60

Arg Lys Asn Tyr Arg Gly Tyr Asn Glu Pro Asp Asp Tyr Ser Thr Gln
 65                  70                  75                  80

Trp Asn Leu Val Met Glu Lys Leu Lys Cys Cys Gly Val Asn Asn Tyr
                 85                  90                  95

Thr Asp Phe Ser Gly Ser Ser Phe Glu Met Thr Thr Gly His Thr Tyr
            100                 105                 110

Pro Arg Ser Cys Cys Lys Ser Ile Gly Ser Val Ser Cys Asp Gly Arg
        115                 120                 125

Asp Val Ser Pro Asn Val Ile His Gln Lys Gly Cys Phe His Lys Leu
    130                 135                 140

Leu Lys Ile Thr Lys Thr Gln Ser Phe Thr Leu Ser Gly Ser Ser Leu
145                 150                 155                 160

Gly Ala Ala Val Ile Gln Leu Pro Gly Ile Leu Ala Thr Leu Leu Leu
                165                 170                 175

Phe Ile Lys Leu Gly 
            180



<210> 16
<211> 128
<212> PRT
<213> Homo sapiens

<400> 16
Ala Arg Ala Arg Pro Ser Arg Ala Ala Pro Pro Leu Pro Pro Pro Arg
  1               5                  10                  15

Ala Asp Ser Ala Ser Gln Lys Met His Tyr Tyr Arg Tyr Ser Asn Ala
             20                  25                  30

Lys Val Ser Cys Trp Tyr Lys Tyr Leu Leu Phe Ser Tyr Asn Ile Ile
         35                  40                  45

Phe Trp Leu Ala Gly Val Val Phe Leu Gly Val Leu Arg Thr Ser Pro
     50                  55                  60

Gln Gln Pro Leu Phe Leu Leu His Ile Leu Gln Pro Pro Ser Met His
 65                  70                  75                  80

Pro Thr Tyr Lys His Ser Pro Thr Ser His Arg Ser Gly Met Asp Cys
                 85                  90                  95

Asn Leu Asn Leu Leu Ala Gly Val Tyr Ile Leu Val Trp Cys Ile Leu
            100                 105                 110

Val Ala Val Asp Asp Asp Phe Phe Phe Phe Thr Gln Phe Ser Val Asp
        115                 120                 125






<210> 17
<211> 161
<212> PRT
<213> Homo sapiens

<220>
<221> SITE
<222> (32)
<223> Xaa equals any of the naturally occurring L-amino acids

<220>
<221> SITE
<222> (33)
<223> Xaa equals any of the naturally occurring L-amino acids

<220>
<221> SITE
<222> (152)
<223> Xaa equals any of the naturally occurring L-amino acids

<220>
<221> SITE
<222> (161)
<223> Xaa equals any of the naturally occurring L-amino acids

<400> 17
Leu Lys Cys Ser Gly Cys Pro Ser Leu Phe Ser Met Ala Glu Ile His
  1              5                  10                  15

Thr Pro Tyr Ser Ser Leu Lys Lys Leu Leu Ser Leu Leu Asn Gly Xaa
             20                  25                  30

Xaa Ala Val Ser Gly Ile Ile Leu Val Gly Leu Gly Ile Gly Gly Lys
         35                  40                  45

Cys Gly Gly Ala Ser Leu Thr Asn Val Leu Gly Leu Ser Ser Ala Tyr
     50                  55                  60

Leu Leu His Val Gly Asn Leu Cys Leu Val Met Gly Cys Ile Thr Val
 65                  70                  75                  80

Leu Leu Gly Cys Ala Gly Trp Tyr Gly Ala Thr Lys Glu Ser Arg Gly
                 85                  90                  95

Thr Leu Leu Phe Cys Ile Leu Ser Met Val Ile Val Leu Ile Met Glu
            100                 105                 110

Val Thr Ala Ala Thr Val Val Leu Leu Phe Phe Pro Ile Val Gly Asp
        115                 120                 125

Val Ala Leu Glu His Thr Phe Val Thr Leu Arg Lys Asn Tyr Arg Gly
    130                 135                 140

Tyr Asn Glu Pro Asp Asp Tyr Xaa Thr Gln Trp Asn Leu Ala Trp Arg
145                 150                 155                 160

Xaa 




<210> 18
<211> 95
<212> PRT
<213> Homo sapiens

<400> 18
Lys Val His Tyr Tyr Arg Tyr Ser Asn Ala Lys Val Ser Cys Trp Tyr
  1              5                  10                  15

Lys Tyr Leu Leu Phe Ser Tyr Asn Ile Ile Phe Trp Leu Ala Gly Val
             20                  25                  30

Val Phe Leu Gly Val Leu Arg Thr Ser Pro Gln Gln Pro Leu Phe Leu
         35                  40                  45

Leu His Ile Leu Gln Pro Pro Ser Met His Pro Thr Tyr Lys His Ser
     50                  55                  60

Pro Thr Ser His Arg Ser Gly Trp Asn Cys Asn Leu Asn Leu Leu Ala
 65                  70                  75                  80

Gly Val Tyr Ile Leu Val Trp Cys Ile Leu Val Ala Val Asp Asp 
                 85                  90                  95



