Re:Search - Details

Prof. James (Jim) Heath, Caltech is providing expertise in designing more stable antibodies

SUBMISSION ID 2121

Contact Details

Provider California Institute of Technology - Caltech
Partnership Hub Coordinator Name BIO Ventures for Global Health
221 Main Street, Suite 1600
San Francisco, CA 94105
USA
Tel: +1 415 446 94 43
partnershiphub@bvgh.org

Submission Summary

TitleProf. James (Jim) Heath, Caltech is providing expertise in designing more stable antibodies
Executive Summary/Abstract Professor James (Jim) Heath leads a laboratory where one group’s researchis in the area of solid-state quantum physics, materials science, and basic surface science, while another group focuses on fundamental biology and translational medicine. On the biology and translational medical side, Heath's group has developed a number of microchip based platforms for highly multiplex analysis of functional proteins from single cells and blood, with specific applications to immune monitoring and tissue analysis, and with a medical focus on oncology.His group also has expertise in creating artificial antibodies that share the high affinity and selectivity of monoclonal antibodies, but maintain the stability of short peptides. They are developing chemistries for targeting these peptides at specific protein epitopes. The superior stability of these capture agents has possible advantages in diagnostic applications for immunoassays, as well as in vivo (imaging andtherapeutic) applications.
Keywords peptide design; stable antibodies; knowhow; diagnostic

Disease Selection

Disease Dracunculiasis (guinea-worm disease);Dengue/dengue hemorrhagic fever;Echinococcosis;Leprosy;Trachoma;Podoconiosis;Tuberculosis;Cysticercosis;Leishmaniasis;Buruli Ulcer;Onchocerciasis;Rabies;Schistosomiasis;Lymphatic filariasis;Human African trypanosomiasis;Foodborne trematode infections (Clonorchiasis, Fascioliasis, Opistorchiasis, Paragonimiasis);Snakebite;Chagas disease (American trypanosomiasis);Endemic treponematoses (Yaws);Soil transmitted helminthiasis;Malaria
Comment
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Type of Data

Type of Data Other Type of Data or Service







OTHER TYPE OF DATA OR SERVICES SUBFIELDS

Data/Service Description

 
Summary/Abstract Text The contribution here is know-how by Prof. Jim Heath who has expertise in designing more stable antibodies that have the stability of short peptides. This could potentially be of interest to organizations like PATH and IDRI working on diagnostics especially antibody diagnostics. This might enable the diagnostic to be more stable for developing world applications. So it would be that organizations would know there is a resource or a person with expertise in developing more stable antibodies and could approach to see if there is interest in a collaboration or just sharing of know how.
Keywords
References

Benefits for Disease

 
Field(s) of Current Application diagnostic; cancer
How to use Data/Service for Disease Contact Prof Heath for sharing knowhow
Potential Benefits for Disease Application This could potentially be of interest to organizations like PATH and IDRI working on diagnostics especially antibody diagnostics. This might enable the diagnostic to be more stable for developing world applications. So it would be that organizations would know there is a resource or a person with expertise in developing more stable antibodies and could approach to see if there is interest in a collaboration or just sharing of know how.

Publication/Patent Status

 
Proprietary Data/Service Yes
How many Patent Families
How many granted patents
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How many Pending Patents
Pending Patent Reference Number(s)

Collaboration Status

 
In house only Yes

 

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