(WO/2006/134605) AMORPHOUS ESOMEPRAZOLE HYDRATE
- Biblio. Data
- Description
- Claims
- National Phase
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| Latest bibliographic data on file with the International Bureau
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| IPC: | C07D 401/12 (2006.01) | |||||||||||
| Applicants: | HETERO DRUGS LIMITED [IN/IN]; Hetero House, 8-3-166/7/1, Erragadda, Hyderabad, Andhrapradesh, Hyderabad 500018 (IN) (All Except US). PARTHASARADHI REDDY, bandi [IN/IN]; (IN) (US Only). RATHNAKAR REDDY, kura [IN/IN]; (IN) (US Only). RAJI REDDY, rapolu [IN/IN]; (IN) (US Only). MURALIDHARA REDDY, dasari [IN/IN]; (IN) (US Only). | |||||||||||
| Inventors: | PARTHASARADHI REDDY, bandi; (IN). RATHNAKAR REDDY, kura; (IN). RAJI REDDY, rapolu; (IN). MURALIDHARA REDDY, dasari; (IN). | |||||||||||
| Title: | AMORPHOUS ESOMEPRAZOLE HYDRATE | |||||||||||
| Abstract: | The present invention relates to a novel amorphous form of esomeprazole hydrate, to a process for its preparation and to a pharmaceutical composition containing it. Thus, tetrahydrofuran and water are added to esomeprazole potassium salt at 25 - 30°C, cooled to 20°C and then the pH is adjusted to 7.5 - 8.0 with acetic acid. The reaction mass is cooled to 5°C, stirred for 2 to 3 hours at 0 - 5°C, filtered the mass, washed with chilled mixture of water and tetrahydrofuran (2 : 1), and again washed with water. The wet cake is dried at 30 - 35°C under vacuum to reach the moisture content to 25 - 30%. The solid is again dried in rotovapour at 25 - 30°C under nitrogen atmosphere to give amorphous esomeprazole hydrate. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
