(WO/2006/091979) FULL KARYOTYPE SINGLE CELL CHROMOSOME ANALYSIS
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| Latest bibliographic data on file with the International Bureau
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| IPC: | C07H 21/04 (2006.01), C12Q 1/68 (2006.01) | |||||||||||
| Applicants: | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 FRANKLIN STREET, 12th Lfoor, Oakland, California 94607-5200 (US) (All Except US). WEIER, Heniz-ulrich [DE/US]; (US) (US Only). MUNNE, Santiago [--/US]; (US) (US Only). REPROGENETICS, LLC [US/US]; 101 OLD SHORT HILLS ROAD, Suite 501, West Orange, New Jersey 07052 (US) (All Except US). | |||||||||||
| Inventors: | WEIER, Heniz-ulrich; (US). MUNNE, Santiago; (US). | |||||||||||
| Agent: | CHEW, Michele et al.; LAWRENCE BERKELEY NATIONAL LABORATORY, One Cyclotron Road, Ms 90b-0104, Berkeley, California 94720 (US). | |||||||||||
| Priority Data: |
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| Title: | FULL KARYOTYPE SINGLE CELL CHROMOSOME ANALYSIS | |||||||||||
| Abstract: | A full set of 24 chromosome-specific probes to analyze single cells or cell organelles to test for abnormalities is described. When used in an assay based on sequential hybridization, the full set is comprised of three subsets of chromosome-specific probes with each set comprised of 8 different probes. Also described are assays using a set of probes to analyze single cells and cellular organelles to accurately determine the number and type of targeted human chromosomes in various types of cells and cell organelles, such as tumor cells, interphase cells and first polar bodies biopsied from non-inseminated oocytes. Methods of selection or generation of suitable probes and hybridization protocols are described, as are preferred probes for full set of 24 chromosome-specific probes to target all 24 human chromosomes are described in the Tables. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
