(WO/2002/024625) PROCESS FOR THE PREPARATION OF 3-ARYL-2-HYDROXY PROPANOIC ACID DERIVATIVES
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| Latest bibliographic data on file with the International Bureau
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| Pub. No.: | WO/2002/024625 | International Application No.: | PCT/IB2001/001699 | |||
| Publication Date: | 28.03.2002 | International Filing Date: | 17.09.2001 | |||
| Chapter 2 Demand Filed: 19.04.2002 | ||||||
| IPC: | C07C 67/00 (2006.01), C07C 67/10 (2006.01), C07C 67/11 (2006.01) | ||||||||||
| Applicants: | DR. REDDY'S RESEARCH FOUNDATION [IN/IN]; 7-1-27, Ameerpet, Hyderabad 500 016 (IN) (All Except US). POTLAPALLY, Rajender, Kumar [IN/IN]; (IN) (US Only). SIRIPRAGADA, Mahender, Rao [IN/IN]; (IN) (US Only). KOTRA, Narasimha, Murthy [IN/IN]; (IN) (US Only). SIRISILLA, Raju [IN/IN]; (IN) (US Only). MAMILLAPALLI, Ramabhadra, Sarma [IN/IN]; (IN) (US Only). GADDAM, Om, Reddy [IN/IN]; (IN) (US Only). | ||||||||||
| Inventors: | POTLAPALLY, Rajender, Kumar; (IN). SIRIPRAGADA, Mahender, Rao; (IN). KOTRA, Narasimha, Murthy; (IN). SIRISILLA, Raju; (IN). MAMILLAPALLI, Ramabhadra, Sarma; (IN). GADDAM, Om, Reddy; (IN). | ||||||||||
| Priority Data: |
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| Title: | PROCESS FOR THE PREPARATION OF 3-ARYL-2-HYDROXY PROPANOIC ACID DERIVATIVES | ||||||||||
| Abstract: | The present invention relates to an improved process for the preparation of 3-aryl-2-hydroxy propanoic acid derivatives of formula (1) where R?1¿ represents hydrogen atom or (C¿1?-C¿6?)alkyl group and R?2¿ represents (C¿1?-C¿6?)alkyl group which comprises: (i) selectively benzylating L-tyrosine to yield compound of formula (15); (ii). diazotising the compound of formula (15) to produce compound of formula (8); (iii) simultaneous etherification and esterification of compound of formula (8) to obtain crude compound of formula (9) with ee>90 %; (iv) hydrolysing the crude compound of formula (9) to produce compound of formula (9a) acid; (v) treating the compound of formula (9a) with chiral base to produce pure salt of formula (16); (vi) converting the compound of formula (16) to pure compound of formula (9a); (vii) esterifying pure compound of formula (9a) to produce pure compound of formula (9); (viii) debenzylating the compound of formula (9) to yield pure compound of formula (1). | ||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW. African Regional Intellectual Property Org. (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). |
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
