(WO/2000/028042) USE OF AN INDUCIBLE GENE FOR THE ENZYME CYCLOOXYGENASE TO LOWER INTRAOCULAR PRESSURE
(WO/2000/028042) USE OF AN INDUCIBLE GENE FOR THE ENZYME CYCLOOXYGENASE TO LOWER INTRAOCULAR PRESSURE
Latest bibliographic data on file with the International Bureau
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| Pub. No.: | | WO/2000/028042 | |
International Application No.: | | PCT/US1999/026069 |
| Publication Date: | 18.05.2000 |
International Filing Date: | 04.11.1999 |
| Chapter 2 Demand Filed: 24.05.2000 |
| IPC: |
A61K 38/44 (2006.01), A61K 48/00 (2006.01) |
| Applicants: | ALCON LABORATORIES, INC. [US/US]; 6021 South Freeway
Fort Worth, TX 76134-2099 (US) (All Except US).
NIXON, Jon, C. [US/US]; (US) (US Only).
GRAFF, Gustav [US/US]; (US) (US Only). |
| Inventors: | NIXON, Jon, C.; (US).
GRAFF, Gustav; (US). |
| Agent: | COPELAND, Barry, L. et al.; Alcon Laboratories, Inc.
R & D Counsel, Q-148
6201 South Freeway
Forth Worth, TX 76134-2099 (US)
. |
| Priority Data: | |
| Title: |
USE OF AN INDUCIBLE GENE FOR THE ENZYME CYCLOOXYGENASE TO LOWER INTRAOCULAR PRESSURE
|
| Abstract: |
A method of lowering intraocular pressure (IOP) employs a gene that encodes a cyclooxygenase (COX) enzyme. Two isoforms of COX (COX-1 and COX-2) produce prostaglandins PGE¿2? and PGF2$g(a). The method of treatment entails administering to the eye of a mammal in need thereof a gene construct encoding a polypeptide having COX activity. In a preferred embodiment the COX enzyme is COX-2. It is also preferred that the gene be inducible with a specific small molecule or cytokine associated with the onset or progression of glaucoma. |
| Designated States: |
AU, BR, CA, JP, MX, US.
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
|
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
