(WO/1994/000565) MORPHINONE REDUCTASE FOR THE PREPARATION OF HYDROMORPHONE AND HYDROCODONE
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
| |||||||||||||||||||
| |||||||||||||||||||
| IPC: | C12N 9/02 (2006.01), C12P 17/18 (2006.01), C12Q 1/32 (2006.01) | ||||||||||||||||||
| Applicants: | MACFARLAN SMITH LIMITED [GB/GB]; Wheatfield Road, Edinburgh EH11 2QA (GB) (All Except US). HAILES, Anne, Maria [GB/GB]; (GB) (US Only). FRENCH, Christopher, Edward [NZ/NZ]; (NZ) (US Only). BRUCE, Neil, Charles [GB/GB]; (GB) (US Only). | ||||||||||||||||||
| Inventors: | HAILES, Anne, Maria; (GB). FRENCH, Christopher, Edward; (NZ). BRUCE, Neil, Charles; (GB). | ||||||||||||||||||
| Agent: | GILL JENNINGS & EVERY; Broadgate House, 7 Eldon Street, London EC2M 7LH (GB). | ||||||||||||||||||
| Priority Data: |
| ||||||||||||||||||
| Title: | MORPHINONE REDUCTASE FOR THE PREPARATION OF HYDROMORPHONE AND HYDROCODONE | ||||||||||||||||||
| Abstract: | A morphinone reductase enzyme having the characteristics: (1) with the NADH cofactor it reduces morphinone to hydromorphone; (2) with the same cofactor it also reduces codeinone and neopinone but has no significant enzymatic activity in the reverse direction; (3) it has a molecular weight of about 81,000, as determined by gel filtration; and (4) in phosphate buffer it exhibits maximal activity at pH about 8.0. | ||||||||||||||||||
| Designated States: |
AU, CA, HU, JP, SK, US. European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE). | ||||||||||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
