(WO/2008/054171) OMEGA CONOTOXINS
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
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| IPC: | A61K 38/17 (2006.01), A61P 25/00 (2006.01) | |||||||||||
| Applicants: | ANYGEN CO., LTD. [KR/KR]; Rm 306, Dept Of Pilot Production, Gwangju Techno P, Gwangju 500-706 (KR) (All Except US). KIM, Jae Il [KR/KR]; (KR) (US Only). RHIM, Hye Whon [KR/KR]; (KR) (US Only). KIM, Hyun Jeong [KR/KR]; (KR) (US Only). SUH, Hong Won [KR/KR]; (KR) (US Only). ROH, Soung Hun [KR/KR]; (KR) (US Only). YUN, Jung A [KR/KR]; (KR) (US Only). LEE, Seung Kyu [KR/KR]; (KR) (US Only). EU, Young Jae [KR/KR]; (KR) (US Only). NA, Heung Sik [KR/KR]; (KR) (US Only). | |||||||||||
| Inventors: | KIM, Jae Il; (KR). RHIM, Hye Whon; (KR). KIM, Hyun Jeong; (KR). SUH, Hong Won; (KR). ROH, Soung Hun; (KR). YUN, Jung A; (KR). LEE, Seung Kyu; (KR). EU, Young Jae; (KR). NA, Heung Sik; (KR). | |||||||||||
| Agent: | YANG, Boo-Hyun; 4th Fl. Oksan Bldg., 1627-10, Bongcheon-7-dong, Gwanak-gu, Seoul 151-818 (KR). | |||||||||||
| Priority Data: |
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| Title: | OMEGA CONOTOXINS | |||||||||||
| Abstract: | The present invention relates to a method for increasing the binding reversibility of a ω-conotoxin to a N-type calcium channel, which comprises preparing a ω-conotoxin having a Ile and/or Ala residue at a position of amino acid (11 and/or 12), respectively in the second loop between cysteine residues (2 and 3) of the ω-conotoxin represented by the formula I, such that the prepared ω-conotoxin has the increased binding reversibility to N-type calcium channel. In addition, the present invention relates to a novel ω-conotoxin and a pharmaceutical composition having plausible properties in view of blocking activity to and specificity to N-type calcium channel, and dramatically improved binding reversibility to N-type calcium channel. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
