(WO/2009/091550) SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS

(WO/2009/091550) SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS

Latest bibliographic data on file with the International Bureau
Pub. No.:  WO/2009/091550   International Application No.:  PCT/US2009/000228
Publication Date:23.07.2009 International Filing Date:13.01.2009
IPC: A61K 38/16 (2006.01)
Applicants:BAYER HEALTHCARE LLC [US/US]; 555 White Plains Road, Tarrytown, NY 10591 (US) (All Except US).
HENTEMAN, Martin, F. [US/US]; (US) (US Only).
SCOTT, William [US/US]; (US) (US Only).
WOOD, Jill [US/US]; (US) (US Only).
JOHNSON, Jeffrey [US/US]; (US) (US Only).
REDMAN, Aniko [US/US]; (US) (US Only).
BULLION, Ann-marie [US/US]; (US) (US Only).
GUERNON, Leatte [US/US]; (US) (US Only).
Inventors:HENTEMAN, Martin, F.; (US).
SCOTT, William; (US).
WOOD, Jill; (US).
JOHNSON, Jeffrey; (US).
REDMAN, Aniko; (US).
BULLION, Ann-marie; (US).
GUERNON, Leatte; (US).
Agent:LOREN, Ralph, A. et al.; Edwards Angell Palmer & Doge LLP, P.O. Box 55874, Boston, MA 02205 (US).
Priority Data:
61/021,029 14.01.2008 US
Title: SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS
Abstract: This invention relates to novel sulfone 2I3-dihydroimidazo[1 l2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language:English (EN)
Filing Language:English (EN)

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