(WO/2009/006404) HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
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| IPC: | C07D 413/12 (2006.01), A61K 31/505 (2006.01), A61P 35/00 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01) | |||||||||||
| Applicants: | SUNESIS PHARMACEUTICALS, INC. [US/US]; 395 Oyster Point Boulevard, Suite 400
South San Francisco, CA 94080 (US) (All Except US). BIOGEN IDEC MA INC. [US/US]; 14 Cambridge Center Cambridge, MA 02142 (US) (All Except US). COSSROW, Jennifer [US/US]; (US) (US Only). GUAN, Bing [US/US]; (US) (US Only). ISHCHENKO, Alexey [UA/US]; (US) (US Only). JONES, John, Howard [CA/US]; (US) (US Only). KUMARAVEL, Gnanasambandam [US/US]; (US) (US Only). LUGOVSKOY, Alexey [RU/US]; (US) (US Only). PENG, Hairuo [CN/US]; (US) (US Only). POWELL, Noel [US/US]; (US) (US Only). RAIMUNDO, Brian [US/US]; (US) (US Only). TANAKA, Hiroko [JP/US]; (US) (US Only). VESSELS, Jeffrey [US/US]; (US) (US Only). WYNN, Thomas [US/US]; (US) (US Only). XIN, Zhili [US/US]; (US) (US Only). | |||||||||||
| Inventors: | COSSROW, Jennifer; (US). GUAN, Bing; (US). ISHCHENKO, Alexey; (US). JONES, John, Howard; (US). KUMARAVEL, Gnanasambandam; (US). LUGOVSKOY, Alexey; (US). PENG, Hairuo; (US). POWELL, Noel; (US). RAIMUNDO, Brian; (US). TANAKA, Hiroko; (US). VESSELS, Jeffrey; (US). WYNN, Thomas; (US). XIN, Zhili; (US). | |||||||||||
| Agent: | ROBIDOUX, Andrea, L.C.; Choate, Hall & Stewart LLP Two International Place Boston, MA 02110 (US). | |||||||||||
| Priority Data: |
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| Title: | HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | |||||||||||
| Abstract: | The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently selected from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L2 is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydrogen or an optionally substituted C1-6 aliphatic group; | |||||||||||
| Designated States: |
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
