(WO/2008/124083) AURORA KINASE MODULATORS AND METHOD OF USE
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
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| IPC: | C07D 401/04 (2006.01), A61K 31/502 (2006.01), A61P 35/00 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 409/04 (2006.01), C07D 471/04 (2006.01), C07D 487/04 (2006.01), C07D 493/04 (2006.01), C07D 495/04 (2006.01) | |||||||||||
| Applicants: | AMGEN INC. [US/US]; One Amgen Center Dr., Patent Operations M/S 28-2-C, Thousand Oaks, California 93012 (US) (All Except US). CEE, Victor, J. [US/US]; (US) (US Only). DEAK, Holly, L. [US/US]; (US) (US Only). GEUNS-MEYER, Stephanie, D. [US/US]; (US) (US Only). DU, Bingfan [US/US]; (US) (US Only). HODOUS, Brian, L. [US/US]; (US) (US Only). MARTIN, Matthew, W. [US/US]; (US) (US Only). NGUYEN, Hanh, Nho [US/US]; (US) (US Only). OLIVIERI, Philip, R. [US/US]; (US) (US Only). PANTER, Kathleen [US/US]; (US) (US Only). ROMERO, Karina [PE/US]; (US) (US Only). SCHENKEL, Laurie [US/US]; (US) (US Only). WHITE, Ryan [US/US]; (US) (US Only). | |||||||||||
| Inventors: | CEE, Victor, J.; (US). DEAK, Holly, L.; (US). GEUNS-MEYER, Stephanie, D.; (US). DU, Bingfan; (US). HODOUS, Brian, L.; (US). MARTIN, Matthew, W.; (US). NGUYEN, Hanh, Nho; (US). OLIVIERI, Philip, R.; (US). PANTER, Kathleen; (US). ROMERO, Karina; (US). SCHENKEL, Laurie; (US). WHITE, Ryan; (US). | |||||||||||
| Agent: | REDDY, G., Prabhakar; Amgen Inc., Law Department, M/S 28-2-C, One Amgen Center Drive, Thousand Oaks, California 91320-1799 (US). | |||||||||||
| Priority Data: |
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| Title: | AURORA KINASE MODULATORS AND METHOD OF USE | |||||||||||
| Abstract: | The present invention relates to chemical compounds having a general formula (I), wherein A1-8, D,, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
