(WO/2008/110846) COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
| ||||||||||||
| ||||||||||||
| IPC: | A61K 31/415 (2006.01), C07D 231/12 (2006.01), C07D 301/00 (2006.01), A61P 35/00 (2006.01) | |||||||||||
| Applicants: | ASTEX THERAPEUTICS LIMITED [GB/GB]; 436 Cambridge Science Park, Milton Road, Cambridge Cambridgeshire CB4 0QA (GB) (All Except US). THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL [GB/GB]; 123 Old Brompton Road, London SW7 3RP (GB) (All Except US). CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Sardinia House, Sardinia Street, London WC2A 3NL (GB) (All Except US). WOODHEAD, Steven John [GB/GB]; (GB) (US Only). REES, David Charles [GB/GB]; (GB) (US Only). FREDERICKSON, Martyn [GB/GB]; (GB) (US Only). GRIMSHAW, Kyla Merriom [GB/GB]; (GB) (US Only). | |||||||||||
| Inventors: | WOODHEAD, Steven John; (GB). REES, David Charles; (GB). FREDERICKSON, Martyn; (GB). GRIMSHAW, Kyla Merriom; (GB). | |||||||||||
| Agent: | HUTCHINS, Michael Richard; Elkington And Fife LLP, Prospect House, 8 Pembroke Road, Sevenoaks Kent TN13 1XR (GB). | |||||||||||
| Priority Data: |
| |||||||||||
| Title: | COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES | |||||||||||
| Abstract: | The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)- 1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)- phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H- pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
