(WO/2008/082766) ENGINEERED SCAFFOLDS FOR INTERVERTEBRAL DISC REPAIR AND REGENERATION AND FOR ARTICULATING JOINT REPAIR AND REGENERATION
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
| ||||||||||||
| ||||||||||||
| IPC: | G06G 7/48 (2006.01) | |||||||||||
| Applicants: | THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; Technology Management Office, Wolverine Tower, Room 2071, 3003 S. State Street, Ann Arbor, MI 48109 (US) (All Except US). WISCONSIN ALUMNI RESEARCH FOUNDATION [US/US]; 614 Walnut Street, Madison, WI 53705 (US) (All Except US). LIN, Chia-Ying [CN/US]; (US) (US Only). LaMARCA, Frank [US/US]; (US) (US Only). FEINBERG, Stephn, E. [US/US]; (US) (US Only). MURPHY, William, L. [US/US]; (US) (US Only). ADOX, James, R. [US/US]; (US) (US Only). HOLLISTER, Scott, J. [US/US]; (US) (US Only). | |||||||||||
| Inventors: | LIN, Chia-Ying; (US). LaMARCA, Frank; (US). FEINBERG, Stephn, E.; (US). MURPHY, William, L.; (US). ADOX, James, R.; (US). HOLLISTER, Scott, J.; (US). | |||||||||||
| Agent: | ROCHE, Richard, T.; Quarles & Brady LLP, 411 E. Wisconsin Ave., Milwaukee, WI 53202 (US). | |||||||||||
| Priority Data: |
| |||||||||||
| Title: | ENGINEERED SCAFFOLDS FOR INTERVERTEBRAL DISC REPAIR AND REGENERATION AND FOR ARTICULATING JOINT REPAIR AND REGENERATION | |||||||||||
| Abstract: | Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The scaffolds are designed with a microstructure that controls elastic and permeability property distribution within the scaffold. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
