(WO/2008/076961) NITRIC OXIDE INCREASES SWITCHING OF T CELLS INTO T REGULATORY CELLS
- Biblio. Data
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| Latest bibliographic data on file with the International Bureau
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| IPC: | C12N 5/02 (2006.01), C12N 5/00 (2006.01) | |||||||||||
| Applicants: | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, Texas 78701 (US) (All Except US). STEPKOWSKI, Stanislaw, M. [US/US]; (US) (US Only). | |||||||||||
| Inventor: | STEPKOWSKI, Stanislaw, M.; (US). | |||||||||||
| Agent: | MINTZ, Carol, G. et al.; CONLEY ROSE, P.C., P.O. Box 3267, Houston, Texas 77253-3267 (US). | |||||||||||
| Priority Data: |
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| Title: | NITRIC OXIDE INCREASES SWITCHING OF T CELLS INTO T REGULATORY CELLS | |||||||||||
| Abstract: | An ex vivo method of expanding a population of regulatory T-cells includes culturing a starting population of cells containing CD4+CD25+ T-cells in a growth medium; introducing nitric oxide into the growth medium sufficient to potentiate switching of the CD4+CD25+ T-cells to CD4+CD25+ regulatory T-cells (Treg cells), whereby a subpopulation of Treg cells is produced; and allowing the Treg cells to proliferate in culture, to provide a final population of T cells containing more Treg cells than were present in the original T-cells. The resulting expanded population of Treg cells are used to deter or decrease an undesired T-cell mediated immune response, e.g., allograft rejection, in a mammalian host by transplanting the Treg cells at a site of a potential or existing undesired immune response, whereby the undesired immune response is deterred or decreased. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
