(WO/2008/057280) MULTI-CYCLIC COMPOUNDS AND METHODS OF USE
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
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| IPC: | C07D 261/06 (2006.01), C07D 401/04 (2006.01), C07D 413/04 (2006.01) | |||||||||||
| Applicants: | AMGEN INC. [US/US]; One Amgen Center Dr. M/S 28-2-c, Thousand Oaks, CA 93012 (US) (All Except US). HODOUS, Brian, L. [US/US]; (US) (US Only). GEUNS-MEYER, Stephanie, D. [US/US]; (US) (US Only). OLIVIERI, Philip, R. [US/US]; (US) (US Only). PATEL, Vinod, F. [US/US]; (US) (US Only). TEMPEST, Paul [US/US]; (US) (US Only). | |||||||||||
| Inventors: | HODOUS, Brian, L.; (US). GEUNS-MEYER, Stephanie, D.; (US). OLIVIERI, Philip, R.; (US). PATEL, Vinod, F.; (US). TEMPEST, Paul; (US). | |||||||||||
| Agent: | REDDY, G., Prabhakar; Amgen Inc., One Amgen Center Drive, Patent Operations / 28-2-c, Thousand Oaks, CA 91320-1799 (US). | |||||||||||
| Priority Data: |
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| Title: | MULTI-CYCLIC COMPOUNDS AND METHODS OF USE | |||||||||||
| Abstract: | The present invention relates to compounds of Formulas I and II, wherein B1, B2, B3, B4, C1, C2, ring D, L1, L2 and R1-4 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and Aurora and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
