(WO/2008/055242) EARLY DETECTION OF DIABETES
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
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| IPC: | C07K 16/18 (2006.01), C07K 16/40 (2006.01), G01N 33/53 (2006.01), G01N 33/555 (2006.01), G01N 33/573 (2006.01), G01N 33/577 (2006.01), G01N 33/66 (2006.01) | |||||||||||
| Applicants: | THE JOHNS HOPKINS UNIVERSITY [US/US]; Johns Hopkins Technology Transfer, 100 North Charles Street, 5th Floor, Baltimore, MD 21201 (US) (All Except US). HART, Gerald, W. [US/US]; (US) (US Only). PARK, Kyoungsook [KR/US]; (US) (US Only). SAUDEK, Christopher, D. [US/US]; (US) (US Only). WANG, Zihao [CN/US]; (US) (US Only). | |||||||||||
| Inventors: | HART, Gerald, W.; (US). PARK, Kyoungsook; (US). SAUDEK, Christopher, D.; (US). WANG, Zihao; (US). | |||||||||||
| Agent: | HAILE, Lisa, A.; DLA Piper US LLP, 4365 Executive Drive, Suite 1100, San Diego, CA 92121-2133 (US). | |||||||||||
| Priority Data: |
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| Title: | EARLY DETECTION OF DIABETES | |||||||||||
| Abstract: | The present invention is based on the discovery that hexosamine, and in particular the dynamic O-GlcNAcylation of proteins (modification of proteins by the sugar N- acetylglucosamine) both causes insulin-resistance (a hallmark of type II diabetes) and is responsible for glucose toxicity in the disease. Accordingly, the invention provides methods of diagnosing a subject as having or at risk of having pre-diabetes or diabetes. Also provided are methods of characterizing hyperglycemia in a subject, methods of identifying a protein as being associated with hyperglycemia, and kits for detecting pre¬ diabetes or diabetes. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
