(WO/2008/005290) METHODS FOR TESTING ANTI-THROMBOTIC AGENTS
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
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| Latest bibliographic data on file with the International Bureau
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| IPC: | C12P 21/02 (2006.01), A61K 38/16 (2006.01), A61K 38/36 (2006.01) | |||||||||||
| Applicants: | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library, 535 West 116th Street, New York, NY 10027 (US) (All Except US). CHEN, Jianchun [US/US]; (US) (US Only). DIACOVO, Thomas [US/US]; (US) (US Only). | |||||||||||
| Inventors: | CHEN, Jianchun; (US). DIACOVO, Thomas; (US). | |||||||||||
| Agent: | BAKER, Hollie, L. et al.; Wilmer Cutler Pickering Hale And Dorr LLP, 399 Park Avenue, New York, NY 10022 (US). | |||||||||||
| Priority Data: |
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| Title: | METHODS FOR TESTING ANTI-THROMBOTIC AGENTS | |||||||||||
| Abstract: | The invention provides a transgenic non-human animal expressing von Willebrand Factor Al protein containing at least one mutation selected from the group consisting of: 1263P>S, 1269N>D, 1274K>R, 1287M>R, 1302G>D, 1308H>R, 1313R>W, 1314I>V, 1326R>H, 1329L>I, 1330E>G, 1333A>D, 1344T>A, 1347I>V, 1350T>A, 1370G>S, 1379H>R, 1381T>A, 1385T>M 1391P>Q, 1394A>S, 1397L>F, 1421S>N, 1439L>V, 1442G>S, 1449R>Q, 1466A>P, 1469Q>L, 1472Q>H, 1473V>M, 1475H>Q, 1479S>G, and any combination thereof. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
