(WO/2006/055806) DIAGNOSTIC, PROGNOSTIC, AND THERAPEUTIC FACTOR SMAC/DIABLO IN HUMAN CANCER
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- Description
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| Latest bibliographic data on file with the International Bureau
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| IPC: | A61K 38/08 (2006.01), C07K 7/06 (2006.01) | |||||||||||
| Applicants: | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, California 94607 (US) (All Except US). KYOTO PREFECTURAL UNIVERSITY OF MEDICINE [JP/JP]; Kawaramachi-hirokoji, Kamigyo-ku, Kyoto 602-8566 (JP) (All Except US). BONAVIDA, Benjamin [US/US]; (US) (US Only). MIKI, Tsuneharu [JP/JP]; (JP) (US Only). MIZUTANI, Yoichi [JP/JP]; (JP) (US Only). | |||||||||||
| Inventors: | BONAVIDA, Benjamin; (US). MIKI, Tsuneharu; (JP). MIZUTANI, Yoichi; (JP). | |||||||||||
| Agent: | PARENT, Annette S. et al.; Townsend And Townsend And Crew LLP, Two Embarcadero Center, 8th Floor, San Francisco, California 94111 (US). | |||||||||||
| Priority Data: |
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| Title: | DIAGNOSTIC, PROGNOSTIC, AND THERAPEUTIC FACTOR SMAC/DIABLO IN HUMAN CANCER | |||||||||||
| Abstract: | The present invention provides, for the first time, the finding that Smac/DIABLO is underexpressed in cancers such as renal cell carcinoma. In particular, the present invention provides methods of diagnosing and providing a prognosis for cancers that underexpress Smac/DIABLO, as well as methods of drug discovery to identify therapeutics useful when used alone or in combination with other cancer therapeutics. The present invention also provides methods of treating or inhibiting cancers that underexpresses Smac/DIABLO, in which potentiation of Smac/DIABLO expression and/or activity sensitizes resistant tumor cells to cytotoxic treatments including chemotherapy, radiation therapy, hormonal therapy, and immunotherapy. Compositions, kits, and integrated systems for carrying out the diagnostic, prognostic, and therapeutic methods of the present invention are also provided. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
