(WO/2001/064929) PRODUCTION OF ANTIBODIES IN TRANSGENIC PLASTIDS
- Biblio. Data
- Description
- Claims
- National Phase
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| Latest bibliographic data on file with the International Bureau
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| IPC: | C07K 16/00 (2006.01), C07K 16/12 (2006.01), C12N 15/82 (2006.01) | ||||||||||||||||||
| Applicants: | AUBURN UNIVERSITY [US/US]; 309 Samford Hall
Auburn University, AL 36849 (US) (All Except US). UNIVERSITY OF CENTRAL FLORIDA [US/US]; 4000 Central Florida Boulevard Orlando, FL 32816 (US) (All Except US). DANIELL, Henry [US/US]; (US) (US Only). WYCOFF, Keith [US/US]; (US) (US Only). | ||||||||||||||||||
| Inventors: | DANIELL, Henry; (US). WYCOFF, Keith; (US). | ||||||||||||||||||
| Agent: | DONATIELLO, Guy, T. et al.; Schnader Harrison Segal & Lewis, LLP 1600 Market Street - Suite 3600 Philadelphia, PA 19103 (US). | ||||||||||||||||||
| Priority Data: |
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| Title: | PRODUCTION OF ANTIBODIES IN TRANSGENIC PLASTIDS | ||||||||||||||||||
| Abstract: | This invention provides compositions and methods for the transformation of plastids of plant cells with multiple genes, and proper association or assembly of multimeric proteins that are heterologous to the plastids of plant cells. A plasmid construct encoding all of the individual polypeptide components of the multimeric protein is provided. Stable integration of the heterologous coding sequences into the plastid genome of the target plant is accomplished through homologous recombination. The present invention achieves assembly of immunoglobulin heavy and light chains, with covalent bonding between the chains, into immunologically active immunoglobulins in the chloroplast. | ||||||||||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW. African Regional Intellectual Property Org. (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG). | ||||||||||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
