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Search result: 77 of 81 |
(WO/2008/014668) ATTENUATED SALMONELLA CARRYING EFFECTIVE PLASMID AND ITS ANTITUMORIGENIC USE
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
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| Latest bibliographic data on file with the International Bureau
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| IPC: | C12N 1/21 (2006.01), A61K 35/74 (2006.01), A61K 38/17 (2006.01), A61K 48/00 (2006.01), A61P 35/00 (2006.01), C12N 15/74 (2006.01), C12R 1/42 (2006.01), C12N 15/12 (2006.01) | |||||||||||
| Applicants: | JILIN UNIVERSITY [CN/CN]; No 2 Xinmin St. Changchun
Jilin 130021 (CN) (All Except US). ZHAO, Xuejian [CN/CN]; (CN) (US Only). ZHANG, Ling [CN/CN]; (CN) (US Only). XU, Deqi [CN/CN]; (CN) (US Only). GAO, Lifang [CN/CN]; (CN) (US Only). | |||||||||||
| Inventors: | ZHAO, Xuejian; (CN). ZHANG, Ling; (CN). XU, Deqi; (CN). GAO, Lifang; (CN). | |||||||||||
| Agent: | JILINCHANGCHUN NEW CENTURY PATENT AGENT LTD.; No. 132, Renmin Street Changchun Jilin (CN). | |||||||||||
| Priority Data: |
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| Title: |
(EN) ATTENUATED SALMONELLA CARRYING EFFECTIVE PLASMID AND ITS ANTITUMORIGENIC USE (ZH) 运载重组质粒的减毒沙门氏菌及其在抗肿瘤中的应用 | |||||||||||
| Abstract: | The present invention relates to attenuated salmonella and its use in treating tumors. The present invention belongs to biological technique field. The present invention discloses the constructions of pH1Si-Stat3, pGRIM-19, and pGRIM-19-Si-Stat3 recombinant plasmid, which coexpresses GRIM-19 and siRNA-Stat3. An attenuation salmonella electrotransformated with the recombinant plasmid is disclosed. The coexpression of GRIM-19 and siRNA-Stat3 has a good synergistic inhibition effect on the growth and metastases of tumors in the experiment in vivo. Attenuated salmonella has phagorytosis effect on tumors, and the progenitive specificity in tumortissue is more than 1000 times as that in normal tissue. The attenuated salmonella carrying effective plasmid, which can coexpresses siRNA-Stat3 and GRIM-19, can reach the deep part of tumors, and thus markedly inhibit their growth and metastases and evidently prolong the survival time of mice. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | Chinese (ZH) |
| Filing Language: | Chinese (ZH) |
