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Search result: 32 of 81 |
(WO/2008/016581) IMAGING NEURONAL ACTIVITY USING NONLINEAR PHASE MODULATION AS AN INTRINSIC CONTRAST MECHANISM
- Biblio. Data
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| Latest bibliographic data on file with the International Bureau
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| IPC: | A61B 6/00 (2006.01) | |||||||||||
| Applicants: | DUKE UNIVERSITY [US/US]; P.o. Box 90083, Durham, NC 27708-0083 (US) (All Except US). FISCHER, Martin, C. [DE/US]; (US) (US Only). WARREN, S., Warren [US/US]; (US) (US Only). | |||||||||||
| Inventors: | FISCHER, Martin, C.; (US). WARREN, S., Warren; (US). | |||||||||||
| Agent: | MAH, Raymond, Y.; NIXON & VANDERHYE P.C., 901 North Glebe Road, 11th Floor, Arlington, VA 22203-1808 (US). | |||||||||||
| Priority Data: |
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| Title: | IMAGING NEURONAL ACTIVITY USING NONLINEAR PHASE MODULATION AS AN INTRINSIC CONTRAST MECHANISM | |||||||||||
| Abstract: | Measurements of two photon absorption (TPA) and/or intrinsic non-linear phase modulation such as self-phase modulation (SPM) or cross- phase modulation (XPM) can be used for neuronal imaging, with potential advantages in speed, penetration depth and molecular contrast. Nonlinear optical processes such as SPM and XPM are known to be sensitive to material structure and are significantly altered by neuronal firing. A pulse shaping technique that extracts weak non-linear phase modulation signatures can be extrapolated to high spatial and temporal resolution while retaining the noninvasive character, thus eliminating the requirement for expressed or exogenous contrast agents. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
