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Search result: 13 of 81 |
(WO/2008/016924) IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN
- Biblio. Data
- Description
- Claims
- National Phase
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| Latest bibliographic data on file with the International Bureau
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| IPC: | A61K 48/00 (2006.01), A61P 9/04 (2006.01), A61P 9/10 (2006.01) | |||||||||||||||
| Applicants: | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th St., Austin, TX 78701 (US) (All Except US). OLSON, Eric [US/US]; (US) (US Only). VAN ROOIJ, Eva [NL/US]; (US) (US Only). | |||||||||||||||
| Inventors: | OLSON, Eric; (US). VAN ROOIJ, Eva; (US). | |||||||||||||||
| Agent: | HIGHLANDER, Steven, L.; FULBRIGHT & JAWORSKI L.L.P., 600 Congress Avenue, Suite 2400, Austin, TX 78701 (US). | |||||||||||||||
| Priority Data: |
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| Title: | IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN | |||||||||||||||
| Abstract: | The present invention relates to the identification of a microRNA, miR-208, that induces the expression of β-myosin heavy chain (β-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders. | |||||||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
