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Search result: 12 of 73 |
(WO/2006/071896) EPITOPE-BASED SARS VACCINE
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
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| IPC: | A61K 39/215 (2006.01), C07K 16/10 (2006.01), C07K 16/42 (2006.01), C12N 15/50 (2006.01), C12Q 1/70 (2006.01) | ||||||||||||||||||
| Applicants: | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY [CN/CN]; Clear Water Bay, Kowloon, Hong Kong (CN) (All Except US). GUO, Zhihong [CN/CN]; (CN) (US Only). ZHONG, Xiaofen [CN/US]; (US) (US Only). GUO, Zufeng [CN/CN]; (CN) (US Only). YANG, Huanghao [CN/CN]; (CN) (US Only). XIE, Yong [US/CN]; (CN) (US Only). | ||||||||||||||||||
| Inventors: | GUO, Zhihong; (CN). ZHONG, Xiaofen; (US). GUO, Zufeng; (CN). YANG, Huanghao; (CN). XIE, Yong; (CN). | ||||||||||||||||||
| Agent: | CHAN, Albert, Wai-Kit; Law Offices of Albert Wai-Kit Chan, World Plaza, Suite 604, 141-07 20th Avenue, Whitestone, NY 11357 (US). | ||||||||||||||||||
| Priority Data: |
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| Title: | EPITOPE-BASED SARS VACCINE | ||||||||||||||||||
| Abstract: | This invention provides a vaccine for the infectious severe acute respiratory syndrome (SARS), which comprises antigenic epitopes from the pathogenic coronavirus. The antigenic epitopes were determined from the complementary antibodies in the plasma of convalescent SARS patients through phage display epitope mapping. These immunodominants consit of short peptide fragments distributed on various viral proteins, which includes, the spike protein, the nucleocapsid protein, the replicase 1a, and the unknown proteins 3a and 9b. Complementary antibodies targeting the immunodominant site on the spike protein effectively neutralize the coronavirus in vitro. This epitope-based vaccine avoids potential immunopathologic effects found in vaccines for other human or animal diseases since the epitopes induced safe and benificial humoral antibodies in convalescent SARS patients. | ||||||||||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | ||||||||||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
