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(WO/2006/009629) METHODS AND AGENTS FOR MAINTAINING MUSCLE MASS AND FOR PREVENTING MUSCLE ATROPHY AND BIOMARKERS FOR MONITORING SAME
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| Latest bibliographic data on file with the International Bureau
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| IPC: | C07H 21/04 (2006.01) | |||||||||||
| Applicants: | NEW YORK UNIVERSITY [US/US]; 650 First Avenue, New York, NY 10016 (US) (All Except US). BURDEN, Steven [US/US]; (US) (US Only). LITTMAN, Daniel [US/US]; (US) (US Only). | |||||||||||
| Inventors: | BURDEN, Steven; (US). LITTMAN, Daniel; (US). | |||||||||||
| Agent: | MALLON, Veronica; Klauber & Jackson, 411 Hackensack Avenue, Hackensack, NJ 07601 (US). | |||||||||||
| Priority Data: |
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| Title: | METHODS AND AGENTS FOR MAINTAINING MUSCLE MASS AND FOR PREVENTING MUSCLE ATROPHY AND BIOMARKERS FOR MONITORING SAME | |||||||||||
| Abstract: | The present invention relates to methods for stimulating muscle growth and/or for inhibiting muscle atrophy in a subject suffering from or predisposed to having a muscle wasting disease by administering an agent that increases the expression of the runx1 gene or gene product in an individual. The invention further provides a biomarker for a muscle wasting disease or condition and methods for screening or diagnosing a subject having, or predisposed to having, a muscle wasting disease by measuring the level of expression of the runx1 gene or gene product in an individual. The invention further relates to the preparation of pharmaceutical compositions using agents that may aid in muscle growth and that may prevent or inhibit muscle atrophy by increasing the expression and/or activity of the runxl gene and/or gene product. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
