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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 1. |
(WO 2008/019403) DUAL-SENSITIZER-CONTAINING LUMINESCENT COMPOUNDS, CONJUGATES, AND USES THEREOF
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14.02.2008
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A61B 5/00
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PCT/US2007/075761
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UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
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The invention relates to novel luminescent compositions of matter containing two fluorophores (sensitizers), synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions and their conjugates in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.
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| 2. |
(WO 2008/019398) ELECTRODEPOSITION OF A POLYMER FILM AS A THIN FILM POLYMER ELECTROLYTE FOR 3D LITHIUM ION BATTERIES
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14.02.2008
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H01M 2/02
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PCT/US2007/075732
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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Systems and methods for depositing a thin polymer layer on a 3D substrate, such as a carbon substrate or the like, by electrochemical means for use as an electrolyte in 3D lithium batteries. This layer stays adhered to the substrate surface by chemical bonding and provides electrical insulation and lithium ion conductivity after the film has been soaked in conventional liquid electrolyte solution containing lithium ions that acts as a plasticiser. In a preferred embodiment, the thin polymer layer is composed of poly(acrylonitrile) (PAN).
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| 3. |
(WO 2008/019395) COMPOUNDS FOR IMPROVING LEARNING AND MEMORY
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14.02.2008
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A01N 37/28
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PCT/US2007/075728
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TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
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The present invention provides a method for improving learning and memory in a subject by administering a therapeutically effective amount of a compound of Formula (I), or of Formula (II), or of Formula (III): (R<sp>1</sp>)<sb>x</sb>-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu -(R<sp>2</sp>)<sb>y</sb>.
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| 4. |
(WO 2008/019381) MIXED CHARGE COPOLYMERS AND HYDROGELS
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14.02.2008
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C08F 220/34
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PCT/US2007/075409
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UNIVERSITY OF WASHINGTON
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Nonfouling copolymers and hydrogels comprising positively charged repeating units or latent positively charged repeating units and negatively charged units or latent positively charged units.
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| 5. |
(WO 2008/019379) USE OF ALLOGENEIC EFFECTOR CELLS AND ANTI-CS1 ANTIBODIES FOR SELECTIVE KILLING OF MULTIPLE MYELOMA CELLS
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14.02.2008
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C12N 5/06
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PCT/US2007/075404
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PDL BIOPHARMA, INC.
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Methods for treating MM using anti-CS1 antibodies are provided herein.
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| 6. |
(WO 2008/019375) PROTEOMIC PATTERNS OF CANCER PROGNOSTIC AND PREDICTIVE SIGNATURES
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14.02.2008
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G01N 33/68
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PCT/US2007/075393
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THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
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The invention provides method for predicting whether a cancer patient will respond to a therapy. Methods of the invention may involve examining protein from a cell of the cancer patient by determining the binding of a panel of antibodies to the protein. Methods of the invention may be used to generate both expression and activation profiles for cells from a cancer patient. Profiles from a cancer patient may then be compared to known profiles for therapy responders and non-responders to predict the individual response of the patient. For example, methods of the invention may be used to determine whether an ovarian or breast cancer patient will respond to a therapeutic protocol.
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| 7. |
(WO 2008/019346) MICROSPHERE-BASED COMPOSITION FOR PREVENTING AND/OR REVERSING NEW-ONSET AUTOIMMUNE DIABETES
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14.02.2008
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A61K 48/00
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PCT/US2007/075292
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BAXTER INTERNATIONAL INC.
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AS-oIigonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to reverse an autoimmune diabetes condition in NOD mice in vivo. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
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| 8. |
(WO 2008/019292) COMPOSITIONS AND METHODS FOR POTENTIATING ANTIBIOTIC ACTIVITY
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14.02.2008
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C07D 405/04
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PCT/US2007/075093
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TRUSTEES OF BOSTON UNIVERSITY
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The present invention provides compounds that potentiate the activity of antibiotic agents, particularly quinolones such as norflaxin. The invention further provides compositions, e.g., pharmaceutical compositions, comprising the inventive compounds. The invention also provides compositions comprising an antibiotic (e.g., a quinolone) and a compound that potentiates activity of the antibiotic. The invention further provides methods of treating a subject comprising administering any of the inventive compounds or compositions to the subject. The invention also provides screening methods to identify compounds that potentiate the activity of an antibiotic, e.g., a quinolone.
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| 9. |
(WO 2008/019291) ANTI-ALIX ANTIBODIES AND HYBRIDOMAS
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14.02.2008
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A61K 39/395
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PCT/US2007/075083
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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The present disclosure, according to specific example embodiments, generally relates to production and methods of use of antibodies. In particular, the present disclosure relates to anti-Alix antibodies and associated methods of using such antibodies in studies relating to Alix, including but not limited to properties such as the structure, function, and distribution of Alix in cells or in a suspension.
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| 10. |
(WO 2008/019241) METHOD FOR VIEWING THREE-DIMENSIONAL DATA SETS
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14.02.2008
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G06T 17/00
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PCT/US2007/074689
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UNIVERSITY OF MIAMI
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The present invention provides a method for viewing three-dimensional data sets. As applied to a three-dimension data set obtained by OCT techniques, a plane at a particular angle is established within the data set, and voxels on either side of the plane may be emphasized relative to other voxels, for example, by increasing the transparency or decreasing the intensity of surrounding voxels. The emphasized voxels may then form a flat slice or slab within the data set that, by analogy with the slit-lamp, may be considered a 'virtual slit' that highlights a section of the data set. The dimmer, non-emphasized surrounding voxels allow the section to be viewed in context. As in the slit-lamp, the method of the present invention may place the slit...
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| 11. |
(WO 2008/019217) STEREOREGULAR ROMP POLYMERS
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14.02.2008
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C08F 4/26
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PCT/US2007/073715
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THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
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The invention relates to stereoregular ROMP polymers, the monomers used to make them, and the processes used to convert the monomers to the polymers.
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| 12. |
(WO 2008/019201) ENHANCED DIAGNOSTIC MULTIMARKER SEROLOGICAL PROFILING
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14.02.2008
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G01N 33/574
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PCT/US2007/072355
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UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
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The present invention is related to methods of early diagnosis of ovarian cancer in a patient by determining serum levels of blood markers using a novel LabMAPTM technology (Luminex Corp., Austin, TX), which allows for simultaneous measurement of the blood markers in serum. The panel of blood markers offers extremely high predictive power for discrimination of ovarian cancer from both healthy control patients and from patients with benign pelvic/ovarian tumors. The methods of the present invention allow for rapid, early diagnosis of ovarian cancer with extremely high sensitivity and specificity to be clinically useful in disease diagnosis.
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| 13. |
(WO 2008/019196) CARBOMETALLATION OF ALKYNES AND IMPROVED SYNTHSIS OF UBIQUINONES
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14.02.2008
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C07F 5/06
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PCT/US2007/071411
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
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| 14. |
(WO 2008/019187) DETECTING AND TREATING DEMENTIA
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14.02.2008
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A61K 38/16
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PCT/US2007/070008
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MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
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This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
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| 15. |
(WO 2008/019186) BLOOD MONOCYTE CD163 EXPRESSION AS A BIOMARKER IN HIV-1 INFECTION AND NEUROAIDS
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14.02.2008
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A61K 39/12
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PCT/US2007/069716
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TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
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The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises contacting the biological sample with an anti-CD163 antibody, so that levels of CD163+/CD16+ peripheral blood mononuclear cells in the biological sample can be quantified. The method of the present invention is particularly useful for monitoring the course of HIV-1 infection and/or HIV Encephalopathy
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| 16. |
(WO 2008/019183) BIOPOLYMER AND PROTEIN PRODUCTION USING TYPE III SECRETION SYSTEMS OF GRAM NEGATIVE BACTERIA
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14.02.2008
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C12P 21/04
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PCT/US2007/069300
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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Proteins, polynucleotide, expression cassette, vector and bacterium compositions for obtaining proteins of interest by expression of same in gram negative bacteria having a Type III secretion system are provided. Uses of the proteins so obtained in the manufacture of isolated proteins, silks, fibers threats, and pharmaceutical compositions are also provided.
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| 17. |
(WO 2008/019182) PRESSURELESSLY SINTERED ZIRCONIUM DIBORIDE/SILICON CARBIDE COMPOSITE BODIES AND A METHOD FOR PRODUCING THE SAME
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14.02.2008
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C04B 35/52
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PCT/US2007/069259
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THE CURATORS OF THE UNIVERSITY OF MISSOURI
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A method of sintering a ZrB2 - SiC composite body at ambient pressures, including blending a first predetermined amount Of ZrB2 powder with a second predetermined amount of SiC powder, wherein both powders are characterized by the presence of surface oxide impurities. Next the blended powders are mixed to yield a substantially homogeneous powder mixture and a portion of the substantially homogeneous powder mixture is formed into a green body. The body is fired to a first temperature, wherein substantially all surface oxide impurities are reduced and/or volatilized to substantially eliminate oxides from the green body, and the body is heated to a second temperature and sintered to yield a composite body of at least about 99 percent theoretic...
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| 18. |
(WO 2008/019181) REDUCIBLE OXIDE BASED CATALYSTS
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14.02.2008
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B01J 23/40
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PCT/US2007/068232
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN
|
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A catalyst is disclosed herein. The catalyst includes a reducible oxide support and at least one noble metal fixed on the reducible oxide support. The noble metal(s) is loaded on the support at a substantially constant temperature and pH.
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| 19. |
(WO 2008/019162) COMPOSITIONS AND METHODS RELATED TO STAPHYLOCOCCAL BACTERIUM PROTEINS
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14.02.2008
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A61K 39/00
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PCT/US2007/060720
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UNIVERSITY OF CHICAGO
|
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The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacteria. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a secreted virulence factor, which may be EsxA and/or EsxB, and/or peptide processed by sortase, which may be SdrD, SdrE, IsdA, IsdB SdrC, Spa, IsdC, CIfA, CIfB, SasF, or combinations thereof.
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| 20. |
(WO 2008/019160) METHOD FOR IDENTIFYING REFRACTIVE-INDEX FLUCTUATIONS OF A TARGET
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14.02.2008
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G01J 3/42
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PCT/US2007/017894
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NORTHWESTERN UNIVERSITY
|
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Systems and methods for identifying refractive-index fluctuations of a target are described in this application. One embodiment includes identifying one or more properties of emergent light, the emergent light to be emergent from a target, and determining refractive-index fluctuations of the target based on the one or more properties of the emergent light. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive- index fluctuations and the spatial correlation length of the refractive- index fluctuations. The determining refractive-index fluctuations further comprises determining one or more of the variance of the refractive- index fluctuations and the spatial correlation lengt...
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| 21. |
(WO 2008/019155) PROCESS OF FLUOROMONOMER POLYMERIZATION
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14.02.2008
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C08F 14/18
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PCT/US2007/017683
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THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
|
| |
Methods of making fluoropolymers from at least one fluoromonomer in either (1) a heterogeneous medium comprising a carbon dioxide and an aqueous phase with or without hydrocarbon surfactants or dispersants or stabilizer, or (2) a homogenous medium containing carbon dioxide with one or more organic solvents, are described.
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| 22. |
(WO 2008/019131) METHODS AND COMPOSITIONS FOR TREATING IGE-MEDIATED DISEASES
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14.02.2008
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A61K 38/00
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PCT/US2007/017479
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
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This invention provides recombinant peptides comprising a fragment of an IgE constant region, nucleotide molecules encoding same, recombinant vaccine vectors comprising same, and methods for inducing immune response and treating allergy, asthma and IgE mediated disease comprising same.
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| 23. |
(WO 2008/019123) ENZYME SENSORS, METHODS FOR PREPARING AND USING SUCH SENSORS, AND METHODS OF DETECTING PROTEASE ACTIVITY
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14.02.2008
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C12N 9/64
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PCT/US2007/017462
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GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
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Embodiments of the present disclosure provide for enzyme sensors, protease sensors, methods for producing and using the enzyme and protease sensors, methods of detecting and/or measuring protease activity, methods fo characterizing protease cellular activity, fusion proteins, polynucleotides, and vectors corresponding to the enzyme and protease sensors, kits, and the like.
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| 24. |
(WO 2008/019100) LIVING RADICAL POLYMERIZATION OF ACTIVATED AND NONACTIVATED MONOMERS CONTAINING ELECTRON-WITHDRAWING SIDE GROUPS
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14.02.2008
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C08F 4/611
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PCT/US2007/017396
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
|
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The invention concerns a method of polymerizing an alkene monomer to produce a polymer using a catalyst that is Cu(O), Cu<sb>2</sb>Te, CuSe, Cu<sb>2</sb>S, Cu<sb>2</sb>O, or a combination thereof, an initiator, and a component comprising a solvent and optional nitrogen-containing ligand, where the combination of the component and monomer is capable of diproportionating Cu(I)X into Cu(O) and Cu(II)X<sb>2</sb> where X is Cl, Br, or I.
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| 25. |
(WO 2008/019060) METHOD FOR PREDICTING ONSET/RISK OF ATRIAL FIBRILLATION (AF)
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14.02.2008
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G01N 33/00
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PCT/US2007/017336
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U.S. DEPARTMENT OF VETERANS AFFAIRS OFFICE OF GENERAL COUNSEL-PSG IV (024)
|
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A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a reactive oxidative metabolite (DROM).
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