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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 1. |
(WO 2008/025016) SYSTEMS AND METHODS FOR HIGH-THROUGHPUT, MINIMALLY-INVASIVE RADIATION BIODOSIMETRY
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28.02.2008
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A61B 5/00
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PCT/US2007/076825
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
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A method for obtaining a sample, determining the sample's metabolomic signature, comparing that signature to at least one known metabolomic signature, and quantifying the radiation exposure of the sample Sample sources may include blood, blood plasma, sweat, urine, sebum, saliva, or cells, or a combination thereof The method may utilize samples obtained noninvasively The method may be capable of high throughput, 50, 100, 1000, 10,000, 100,000, or more samples per hour The method may utilize samples from mice, humans, or other mammals The method may utilize chromatography, mass spectroscopy, or radiofrequency differential ion mobility spectrometry analysis, or a combination thereof The method may employ software for comparing the metabolomic...
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| 2. |
(WO 2008/025015) EPITOPE-PROTEIN SCAFFOLDS AND THEIR USE
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28.02.2008
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G06F 19/00
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PCT/US2007/076824
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THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
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Computational protocols for the design of epitope-protein scaffolds which elicit selected neutralizing antibodies are disclosed, and related compositions and uses.
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| 3. |
(WO 2008/024971) RECURSIVELY PARTIONED STATIC IP ROUTER TABLES
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28.02.2008
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H04L 12/28
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PCT/US2007/076756
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UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.
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A recursively partitioned static router-table, the data structure incorporating a <i>first-level</i> partition including subtries and an auxiliary trie. A node of the subtrie includes a path Q(N) from the root <i>R</i> of a trie <i>T</i> to a root <i>N</i> of the subtrie, a stride <i>s</i> for a <i>next-level</i> partition, a mask that characterizes a <i>next-level</i> perfect hash function, and a pointer to the hash table for the <i>next-level </i>partition. At least one of the trie T, the <i>first-level</i> partition, the auxiliary trie, and the <i>nex...
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| 4. |
(WO 2008/024966) ELECTROSTATIC PARTICLE EXPOSURE SYSTEM AND METHOD OF EXPOSING A TARGET MATERIAL TO SMALL PARTICLES
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28.02.2008
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H02H 1/00
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PCT/US2007/076746
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THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE
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A system for exposing a target material to small particles. The system includes an exposure chamber that receives the target material. A stream of charged particles is directed via an inlet into the exposure chamber toward the target material. One or more electrodes are located relative to the target material and the inlet, and are electrically charged, so as to cause at least some of the charged particles to impact upon the target material. The system can be used to expose the target material to small, for example, nanoscale, particles in a gas environment.
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| 5. |
(WO 2008/024953) TRANSITION METAL-CATALYZED ALKYLATION OF C-H BONDS WITH ORGANOBORON REAGENTS
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28.02.2008
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C07D 213/06
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PCT/US2007/076725
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BRANDEIS UNIVERSITY
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One aspect of the present invention relates to methods for functionalization of 2-arylpyridine and arylpyrazoles with organoboron reagents in the presence of a transition metal catalyst to furnish alkylated arylpyridines and arylpyrazoles via regioselective functionalization of sp<sp>2</sp> -hybridized C-H bonds at a position ortho to the point of attachment of the pyridine or pyrazole ring to the aromatic nucleus, hi other embodiments, the present invention provides for alkylation of sp<sp>3</sp>-hybridized C-H bonds in alkylpyridines.
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| 6. |
(WO 2008/024950) METHODS FOR PRODUCING MATERIALS WITH PHOTO- AND ELECTROLUMINESCENCE PROPERTIES AND SYSTEMS USING SUCH MATERIALS
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28.02.2008
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C09K 11/06
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PCT/US2007/076719
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The University of Akron
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The invention is directed to a method of preparing polymeric metallomacrocycles having measurable photo- and electroluminescence properties and devices using such materials. In an embodiment, an <i>O</i>-hexyl-3,5-bis(terpyridine)phenol ligand has been synthesized and transformed into a hexagonal Zn(II)-metallomacrocycle by a facile self-assembly procedure capitalizing on terpyridine-Zn(II)-terpyridine connectivity. The material is usable in an OLED device based on the photo- and electro-luminescence characteristics thereof.
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| 7. |
(WO 2008/024919) INTERFERON ANTAGONISTS, ANTIBODIES THERETO, AND ASSOCIATED METHODS OF USE
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28.02.2008
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A61K 38/21
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PCT/US2007/076655
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UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
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[00243] Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the invention relates to antagonists of interferon proteins and associated methods of use as well as methods to develop neutralizing antibodies against IFN antagonists to treat viral infections.
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| 8. |
(WO 2008/024902) TARGETING OF FRUCTOKINASE AS THERAPY FOR CARDIOVASCULAR DISEASE, METABOLIC SYNDROME, AND RENAL DISEASE
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28.02.2008
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C12Q 1/48
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PCT/US2007/076624
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UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
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Disclosed herein are methods of treating and/or preventing hypertension, metabolic syndrome, and/or renal disease that involve the targeting of Fructokinase (ketohexokinase). Also disclosed herein are methods of screening for inhibitors of Fructokinase. Further disclosed herein are methods of formulating a prescriptive regimen for hypertension, metabolic syndrome, and/or renal disease that comprises evaluating the level of ketohexokinase activity in an individual.
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| 9. |
(WO 2008/024885) SYMMETRIC, SPATULAR ATTACHMENTS FOR ENHANCED ADHESION OF MICRO-AND NANO-FIBERS
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28.02.2008
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C09J 5/00
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PCT/US2007/076582
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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A fabricated nano-structure includes a substrate, a supporting stalk, a node, and at least two spatular plate portions. The first end of the. supporting stalk is connected to the substrate. The supporting stalk has a diameter range of about 50 nanometers to about 2 microns. A node is disposed at the second end of the supporting stalk. At least two spatular plate portions are connected to the node. The spatular plate portions have planar geometries and are radially distributed about the node. The spatular plate portions have a ratio of a maximum plate thickness to a maximum plate length of at most about 1:20. The maximum plate length is at least about 100 nanometers. The spatular plate portions adhere to a contact surface using intermolecula...
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| 10. |
(WO 2008/024879) USE OF TETANUS TOXIN TO AMPLIFY INADEQUATE VOLUNTARY MUSCLE CONTRACTION OR TO IMPROVE MUSCLE TONE IN AN ANIMAL ACTIVELY VACCINATED AGAINST THE TOXIN AND A REGIMEN FOR TREATMENT
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28.02.2008
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A61K 39/08
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PCT/US2007/076575
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UNIVERSITY OF MARYLAND, BALTIMORE
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A method of improving functional movement of a muscle in an animal in need thereof comprising administering to the muscle of an animal, which is actively vaccinated against tetanus toxin and which has a compromised central nervous system, an inadequate voluntary muscle contraction-amplifying amount of tetanus toxin; a method of improving the tone of a muscle in an animal comprising administering to the muscle of the animal, which is actively vaccinated against the toxin, a muscle tone-improving amount of tetanus toxin; and a regimen for dosage escalation of tetanus toxin comprising an initial dose and subsequent doses, wherein the initial dose is about 0.5 µg tetanus toxin/muscle, each subsequent dose is at least about 2-fold higher than a...
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| 11. |
(WO 2008/024868) METHOD OF OBTAINING A TREATMENT COMPOSITION FOR IMPROVING THE PRODUCTIVITY OF HYDROCARBON PRODUCING WELLS
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28.02.2008
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E21B 43/22
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PCT/US2007/076562
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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A method of obtaining a treatment composition for treating a hydrocarbon-bearing clastic formation having brine therein to enhance recovery of hydrocarbon from the formation. The method comprises: obtaining a formation information set comprising a temperature value, brine content value, and brine composition data obtained from a geological zone of the hydrocarbon-bearing clastic formation; comparing the formation information set to a compatibility information set to generate a comparison information set, the compatibility information set comprising compatibility information for at least at least one model brine and at least one model composition at at least one model temperature; selecting a treatment composition based, at least in part, on...
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| 12. |
(WO 2008/024865) COMPOSITIONS AND METHODS FOR IMPROVING THE PRODUCTIVITY OF HYDROCARBON PRODUCING WELLS
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28.02.2008
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C09K 8/60
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PCT/US2007/076558
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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Compositions comprise nonionic fluorinated polymeric surfactants and solvent. The solvent comprises: at least one of a polyol or polyol ether, wherein the polyol and polyol ether have from 2 to 25 carbon atoms; and at least one monohydroxy alcohol, ether, or ketone having from 1 to 4 carbon atoms, or a mixture thereof, wherein the solvent is capable of at least one of solubilizing or displacing brine or condensate in the hydrocarbon-bearing clastic formation. Embodiments of the compositions are useful in recovery of hydrocarbons from hydrocarbon-bearing clastic formations that contain brine and/or condensate.
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| 13. |
(WO 2008/024864) AMINO ACID OLIGOMER DIETARY SUPPLEMENT
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28.02.2008
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A23K 1/00
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PCT/US2007/076557
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THE CURATORS OF THE UNIVERSITY OF MISSOURI
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A method for supplementing the levels of select amino acids in ruminants is provided. Amino acids are susceptible to microbial degradation in the rumen, where the relative susceptibility of an amino acid oligomer is determined primarily by its solubility in the rumen fluid. A method for designing and preparing microbial resistant amino acid oligomers based on relative solubility is also provided. Various compositions containing amino acids are disclosed and shown to resist microbial degradation in ruminants.
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| 14. |
(WO 2008/024858) METHODS AND COMPOUNDS REGULATING THE ERYTHROID RESPONSE TO IRON DEFICIENCY
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28.02.2008
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A61K 38/00
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PCT/US2007/076546
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UNIVERSITY OF VIRGINIA PATENT FOUNDATION
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The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.
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| 15. |
(WO 2008/024857) AN APPARATUS AND METHOD FOR OPTIMIZATION OF CARDIAC RESYNCHRONIZATION THERAPY
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28.02.2008
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A61N 1/368
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PCT/US2007/076543
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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An apparatus ( 10) and method for biventricular pacing comprises means and steps for i) evidence-based, 11) optimized, in) simultaneously evidence-based and optimized endomyocardium and ιv) optimized epimyocardium pacing in cardiac resynchronization Monophasic action potential is mapped by evidence-based and individualized optimization of cardiac resynchronization, pacing and implantable cardioverter defibrillators in percutaneous procedures, thoracoscopic procedures or open chest surgeries The optimized electrode sites are identified without MAP mapping without use of an electrophysiologic system for optimι/ed cardiac resynchronization, pacing and an implantable cardioverter defibrillator in percutaneous procedures, thoracoscopic procedu...
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| 16. |
(WO 2008/024844) ANTICANCER COMBINATION THERAPIES
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28.02.2008
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A01N 43/04
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PCT/US2007/076525
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THE JOHNS HOPKINS UNIVERSITY
|
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Methods for treating or preventing hyperproliferating diseases, e.g., cancer, are described. A method may comprise administering to a subject in need thereof a therapeutically effective amount of a chemotherapeutic agent and a DNA vaccine.
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| 17. |
(WO 2008/024830) RADIOHALOIMATINIBS AND METHODS OF THEIR SYNTHESIS AND USE IN PET IMAGING OF CANCERS
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28.02.2008
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A61K 51/00
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PCT/US2007/076503
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.
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| 18. |
(WO 2008/024829) RADIOHALOIMATINIBS AND METHODS OF THEIR SYNTHESIS AND USE IN PET IMAGING OF CANCERS
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28.02.2008
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A61K 31/497
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PCT/US2007/076501
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.
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| 19. |
(WO 2008/024826) RADIOHALOTHYMIDINES AND METHODS OF THEIR SYNTHESIS AND USE IN PET IMAGING OF CANCERS
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28.02.2008
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A61K 51/00
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PCT/US2007/076498
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells. We also disclose specific N<sp>3</sp> -radiohaloalkyl thymidines and salts thereof.
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| 20. |
(WO 2008/024790) TEMPLATES FOR ASSESSING BONE QUALITY AND METHODS OF USE THEREOF
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28.02.2008
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G06K 9/00
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PCT/US2007/076441
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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The present invention relates to the preparation and use of novel bone templates that can be prepared using a comprehensive approach to observing microstructural features of bone, including trabecular thickness and trabecular density. These features are assessed in regions of interest in a bone (e.g., proximal femur, distal femur, wrist, spine, etc.) as observed using digital radiographic techniques or clinical imaging, such as Dual Energy X-ray Absorptiometry (DEXA) and computed tomography (CT) scanners. The microstructural features are presented in the form of data based on scanning results and are also assessed and/or organized in terms of age, gender, race, pathology, clinical history, and other patient population parameters. The templa...
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| 21. |
(WO 2008/024783) LITHOGRAPHICALLY PATTERNED NANOWIRE ELECTRODEPOSITION
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28.02.2008
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H01B 13/00
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PCT/US2007/076433
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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Lithographically patterned nanowire electrodeposition (LPNE) combines attributes of photolithography with the versatility of bottom-up electrochemical synthesis. Photolithography is employed to define the position of a sacrificial nanoband electrode, preferably formed from a metal such as nickel, copper, silver, gold or the like, which is stripped using electrooxidation or a chemical etchant to advantageously recess the nanoband electrode between a substrate surface and the photoresist to form a trench defined by the substrate surface, the photoresist and the nanoband electrode. The trench acts as a 'nanoform' to form an incipient nanowire during its electrodeposition. The width of the nanowire is determined by the electrodeposition duratio...
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| 22. |
(WO 2008/024772) IMAGE-BASED SYSTEM AND METHOD FOR VEHICLE GUIDANCE AND NAVIGATION
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28.02.2008
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G05D 1/10
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PCT/US2007/076419
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UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
|
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A method of estimating position and orientation of a vehicle using image data is provided. The method includes capturing an image of a region external to the vehicle using a camera mounted to the vehicle, and identifying in the image a set of feature points of the region. The method further includes subsequently capturing another image of the region from a different orientation of the camera, and identifying in the image the same set of feature points. A pose estimation of the vehicle is generated based upon the identified set of feature points and corresponding to the region. Each of the steps are repeated at with respect to a different region at least once so as to generate at least one succeeding pose estimation of the vehicle. The pose ...
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| 23. |
(WO 2008/024771) METHOD TO REPAIR A DAMAGED INTERVERTEBRAL DISC THROUGH THE USE OF A BIOADHESIVE, THERMOGELLING HYDROGEL
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28.02.2008
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A61L 27/14
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PCT/US2007/076417
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SYNTHES (U.S.A.)
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The present invention is directed to a bioadhesive thermogelling hydrogel composition for repairing and/or augmenting an intervertebral disc. The bioadhesive thermogelling hydrogel composition can be cross linked with the surrounding tissue so as to potentially serve as a nucleus pulposus replacement or augmentation along with serving to repair annular tears or fissure. The bioadhesive thermogelling hydrogel composition may include three main components: a thermal responsive polymer, an amine-containing polymer and a crosslinking component. All three components can be modified and combined in numerous ways to serve the need of the system as long as the amine-containing component is kept separate from the crosslinking component until the com...
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| 24. |
(WO 2008/024759) IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE PY+3 BINDING SITE OF TYROSENE KINASE P56 LCK SH2 DOMAIN
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28.02.2008
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A61K 31/33
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PCT/US2007/076402
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UNIVERSITY OF MARYLAND, BALTIMORE
|
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Small molecular-weight non-peptidic compounds block Lck SH2 domain-dependent interactions. The inhibitors omit phosphotyrosine (pY) or related moieties.
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| 25. |
(WO 2008/024753) LIPID-DERIVED NANOPARTICLES FOR BRAIN-TARGETED DRUG DELIVERY
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28.02.2008
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A61K 9/127
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PCT/US2007/076389
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WAYNE STATE UNIVERSITY
|
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Disclosed herein are compositions and methods useful for the delivery of compounds across the blood brain barrier. Nanoparticles comprising lipids, such as brain lipids, are used to encapsulate drugs and to facilitate drug delivery to the brain.
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