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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 51. |
(WO 2008/008380) COMBINATION THERAPY FOR ADDICTION DISORDERS
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17.01.2008
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A01N 37/12
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PCT/US2007/015795
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REGENTS OF THE UNIVERSITY OF MINNESOTA
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| |
The present invention provides a therapeutic method comprising administering at least one opioid receptor antagonist and at least one glutathione-increasing agent to an individual afflicted with an addiction disorder, in amounts that are effective to eliminate or reduce at least one symptom of said addiction disorder.
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| 52. |
(WO 2008/008358) ANTI-COCAINE COMPOSITIONS AND TREATMENT
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17.01.2008
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A61K 38/46
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PCT/US2007/015762
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COLUMBIA UNIVERSITY
|
| |
Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.
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| 53. |
(WO 2008/008356) FRET-BASED APOPTOSIS DETECTOR
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17.01.2008
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A61K 45/00
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PCT/US2007/015760
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THE REGENTS OF THE UNIVERSITY OF MICHIGAN
|
| |
The present invention relates to compositions comprising a FRET-based substrate, a cell-targeting moiety and a dendrimer, and methods for generating and using the same.
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| 54. |
(WO 2008/008349) METHODS OF QUANTITATIVELY ASSESSING INFLAMMATION WITH BIOSENSING NANOPARTICLES
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17.01.2008
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G01N 33/53
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PCT/US2007/015748
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DREXEL UNIVERSITY
|
| |
The present invention includes a method of using one or more biomarkers to identify individuals with inflammatory disease using Quantum Dots conjugated to targeting moieties that will specifically bind to biomarker proteins or nucleic acids encoding the biomarker, where detection of the biomarker is associated with the inflammatory disease.
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| |
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| 55. |
(WO 2008/008311) METHODS FOR ADMINISTERING TUMOR VACCINES
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17.01.2008
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A61K 38/00
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PCT/US2007/015686
|
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
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| |
The present invention provides methods of inducing an immune response in a subject against a protein of interest and treating and suppressing a formation of a tumor comprising a tumor-associated protein, comprising sequential administration of fragments of the protein. The present invention also provides Her-2 protein fragments, recombinant peptides comprising same, nucleotide molecules encoding same, recombinant vaccine vectors and immunogenic compositions comprising same, and methods for inducing immune response and treating cancer, comprising same.
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| 56. |
(WO 2008/008284) CANCER BIOMARKERS AND METHODS OF USE THREOF
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17.01.2008
|
G01N 33/543
|
PCT/US2007/015584
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
The present invention provides detection methods for detecting a pre-cancerous epithelial cell signature. The present invention further provides reagents for use in the detection methods. A subject detection method is useful in various imaging, diagnostic, prognostic, and patient monitoring methods, which are also provided.
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| 57. |
(WO 2008/008266) BIOHYBRID ELASTOMERIC SCAFFOLDS AND METHODS OF USE THEREOF
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17.01.2008
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A61F 2/02
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PCT/US2007/015519
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UNIVERSITY OF PITTSBURGH- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
|
| |
Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
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| 58. |
(WO 2008/008264) SELECTIVE CASPASE INHIBITORS
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17.01.2008
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A61K 38/07
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PCT/US2007/015516
|
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
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| |
Described here are novel, highly selective inhibitors and activity based probes (ABPs) for caspases 3, 7, 8, and 9 and legumain. The compounds selectively inhibit only certain caspases. A positional scanning combinatorial library (PSCL) approach was used to screen pools of peptide acyloxymethyl ketones (AOMKs) containing both natural and non-natural amino acids for activity against a number of purified recombinant caspases. These screens were used to identify structural elements at multiple positions on the peptide scaffold that could be modulated to control inhibitor specificity towards target caspases. Further disclosed are individual optimized covalent inhibitors that could also be equipped with various tags for use as activity based pro...
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| 59. |
(WO 2008/008256) METHODS FOR ENHANCING PRODUCTION OF ISOPRENOID COMPOUNDS BY HOST CELLS
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17.01.2008
|
C12P 21/00
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PCT/US2007/015498
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a host cell that comprises a biosynthetic pathway that converts a substrate to isopentenyl pyrophosphate, where the biosynthetic pathway is modified to include a synthetic intergenic region (IGR) between at least two coding regions encoding enzymes in the biosynthetic pathway. The present invention further provides recombinant nucleic acid constructs comprising a synthetic IGR, and genetically modified host cells comprising a synthetic IGR.
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| 60. |
(WO 2008/008247) NEAR ULTRAVIOLET-WAVELENGTH PHOTONIC-CRYSTAL BIOSENSOR WITH ENHANCED SURFACE TO BULK SENSITIVITY RATIO
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17.01.2008
|
G01N 21/47
|
PCT/US2007/015448
|
The Board of Trustees of the University of Illinois
|
| |
Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled- Wave Analysis simulations predict a more tightly confined resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These new biosensors can be fabricated in mass by replica molding. They are especially well suited for applications requiring the detection of small molecul...
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| 61. |
(WO 2008/008229) DE NOVO FORMATION AND REGENERATION OF VASCULARIZED TISSUE FROM TISSUE PROGENITOR CELLS AND VASCULAR PROGENITOR CELLS
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17.01.2008
|
A61F 2/01
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PCT/US2007/015293
|
COLUMBIA UNIVERSITY
|
| |
It has been discovered that vascularized tissue or organs can be engineered by combined actions of tissue progenitor cells and vascular progenitor cells. Provided herein are compositions and methods directed to engineered vascularized tissue or organs formed by introducing tissue progenitor cells and vascular progenitor into or onto a biocompatible scaffold of matrix material. Also provided are methods of treating tissue defects via grafting of such compositions into subjects in need thereof.
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| 62. |
(WO 2008/008224) SOUR TASTE RECEPTOR COMPOSITIONS AND METHODS
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17.01.2008
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G01N 33/53
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PCT/US2007/015288
|
DUKE UNIVERSITY
|
| |
The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
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| 63. |
(WO 2008/008155) SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING
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17.01.2008
|
C12Q 1/68
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PCT/US2007/014366
|
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
|
| |
This invention relates to methods for identifying compound capable of activating p53-responsive transcriptional activity in a p53-deficient tumor cell and the use of these compunds.
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| 64. |
(WO 2008/008130) CHEMICAL PROTECTION OF METAL SURFACE
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17.01.2008
|
H01M 4/02
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PCT/US2007/012613
|
TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
|
| |
An electrochemical cell includes an anode having a metal material having an oxygen containing layer. The electrochemical cell also includes a cathode and an electrolyte. The anode includes a chemically bonded protective layer formed by reacting a D or P block precursor with the oxygen containing layer.
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| 65. |
(WO 2008/008114) USE OF ADIPOSE-DERIVED STEM CELLS FOR TREATMENT OF LEUKODYSTROPHIES
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17.01.2008
|
A61K 35/12
|
PCT/US2007/011438
|
THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
|
| |
The present invention relates to a treatment of a leukodystrophy by administration of an adipose-derived stem cell. Specifically, the present invention relates to the treatment of Krabbe disease with an adipose derived stem cell differentiated to express galactocerebrosidase.
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| |
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| 66. |
(WO 2008/008092) CAMPYLOBACTER PILUS PROTEIN, COMPOSITIONS AND METHODS
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17.01.2008
|
A01N 37/18
|
PCT/US2006/061470
|
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
|
| |
The present disclosure provides coding and amino acid sequences for a Campylobacter jejuni pilus protein (and from other species as well). This protein, when administered to a human or animal, elicits the expression of an immune response to Campylobacter jejuni, with the result that colonization and/or infection by this organism is reduced. Recombinant protein or biofilm material comprising the pilus protein is formulated into immunogenic compositions, especially for mucosal administration. Thus, the present invention provides methods for improvement of the microbial quality of food products including poultry, eggs, meat and dairy products, and indirectly of plant foods that may come in contact with agricultural waste, either from fertiliza...
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| 67. |
(WO 2008/008086) COMPOSITES FOR WIRELESS OPTICAL COMMUNICATION
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17.01.2008
|
H04B 10/06
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PCT/US2006/040356
|
UNIVERSITY OF DELAWARE
|
| |
An apparatus and process for operating connectorless, free- space data porting optical structural composites with integrated optical or electrical busses are disclosed. Optical transceivers and fiber optic/coaxial cable are embedded into a foam-core composite sandwich structure which is infiltrated with vinyl ester resin. The embedded busses are composed of a signal source producing an optical free space signal, which is shone onto an optical/electrical bus containing a transceiver for converting this signal into another electrical or optical signal which then is imprinted upon a coaxial or fiber optic cable buried in the composite structure. The signal traverses the composite structure, then a transceiver converts the electrical/optical si...
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| |
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| 68. |
(WO 2008/007932) CHITOSAN COMPLEX CONTAINING PH SENSITIVE IMIDAZOLE GROUP AND PREPARATION METHOD THEREOF
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17.01.2008
|
A61K 47/36
|
PCT/KR2007/003447
|
UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
|
| |
Disclosed herein a chitosan complex containing a pH-sensitive imidazole group and a method for the preparation thereof. The amino group of glycol chitosan is linked via amide bond to the histidine of the imidazole, which is hydrophobic in a neural range, but hydrophilic in a weak acid region an imidazole group via an amide bond between the amino group of glycol chitosan. The chitosan complex can be loaded with various hydrophobic drugs, such as anticancer agents and gene, and labeled with traceable radioisotopes, so that it is useful as a drug delivery system, a scintigraphical tracer and a gene carrier.
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| |
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| 69. |
(WO 2008/007880) A COMPOSITION COMPRISING AN EXTRACT OF PRUNUS PERSICA (L.) BATSCH FOR TREATING AND PREVENTING BONE DISEASES
|
17.01.2008
|
A61K 36/736
|
PCT/KR2007/003318
|
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
|
| |
The crude extract, polar solvent soluble or non-polar solvent soluble extract of Prunus persica (L.) BATSCH of the present invention inhibitedthe formation of osteoclasts in mouse bone marrow macrophages treated with RANKL and the bone resorption by osteoclasts without harmful effect on the viability of mouse bone marrow macrophage cells. Accordingly, it can be used as the therapeutics or health food for treating and preventing bone diseases.
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| 70. |
(WO 2008/007859) METHOD FOR TRANSMITTING WIRELESS DATA AND RECORDING MEDIUM STORING PROGRAM FOR EXECUTING THE METHOD
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17.01.2008
|
H04L 29/02
|
PCT/KR2007/002645
|
KANGNUNG NATIONAL UNIVERSITY INDUSTRY ACADEMY CORPORATION GROUP
|
| |
A method of transmitting wireless data and a recorded medium storing a computer program therefor. The method of transmitting data by a sender coupled to a receiver through a network can include transmitting a data frame having an Initiation field to the sender and transmitting a plurality of data frames corresponding to the Initiation field. The present invention can improve the completion rate of data transmission under an extremely-poor wireless environment.
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| |
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| 71. |
(WO 2008/007856) AUTOMATIC VELOCITY CONTROL RUNNING MACHINE USING PRESSURE SENSOR ARRAY AND FUZZY-LOGIC
|
17.01.2008
|
A63B 22/02
|
PCT/KR2007/002481
|
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YEUNGNAM UNIVERSITY
|
| |
The present invention relates to an automatic speed-controlled treadmill using a pressure sensor array and a method of operating the same. The automatic speed-controlled treadmill includes a walking belt, a pressure sensor array including pressure sensors for detecting loads of the exerciser's feet and outputting the detected loads of the feet as load detection signals, a pace speed status storage unit for storing a pace speed and variation in pace speed of the exerciser, and a control unit provided with an algorithm for calculating a pace speed of the exerciser using the load detection signals, calculating a difference between a previous pace speed and a current pace speed as the variation in pace speed, calculating the exercise center of ...
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| 72. |
(WO 2008/007854) ARABIDOSIS ATLEJ1 GENE INVOLVED IN INHIBITING BIOSYNTHESIS OF JASMONIC ACID AND ETHYLENE AND METHOD FOR PRODUCING MALE-STERILE PLANT USING THE SAME
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17.01.2008
|
C12N 15/29
|
PCT/KR2007/001524
|
KOREA UNIVERSITY INDUSTRIAL AND ACADEMIC COLLABORATION FOUNDATION
|
| |
Disclosed herein are an Arabidopsis gene (AtLEJl), acting as an inhibitor of the biosynthesis of the phytohormones jasmonic acid and ethylene, and a method for producing a male sterile transgenic plant using the same. The gene guarantees stable male sterile strains which need no maintainers for the maintenance thereof. Also, the transgenic plants comprising the gene can be readily restored to a fertile phenotype merely through hormonal treatment.
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| 73. |
(WO 2008/007838) STAGE WITH DISPLACEMENT MAGNIFICATION MECHANISM FOR MEASURING
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17.01.2008
|
G01B 11/02
|
PCT/KR2006/005675
|
PUSAN NATIONAL UNIVERSITY INDUSTRY UNIVERSITY COOPERATION FOUNDATION
|
| |
The present invention relates to a stage with a displacement measuring means capable of measuring a displacement, and more particularly, to a stage provided with a displacement magnification means capable of magnifying a displacement so as to precisely measure a minute displacement on the order of nanometers. A stage according to an aspect of the present invention comprises a fixed base, a movable table, a first elastic support, a first actuator, a first displacement converting means and a first displacement measuring means. The movable table is installed to be movable with respect to the fixed base. The first elastic support supports the movable table with respect to the fixed base, and the first actuator generates a displacement of the mo...
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| 74. |
(WO 2008/007825) QUARTERNIZED AMINO GLUCOSAMINE COMPOUND FOR EXERTING ANTICANCER EFFECT
|
17.01.2008
|
C07H 5/06
|
PCT/KR2006/003671
|
PUKYONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
|
| |
The present invention relates to the quarternized amino glucosamine, it can exert an anticancer effect via induction of apoptosis in a dose and time dependant manner through which an anticancer treatment effect can be increased.
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| |
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| 75. |
(WO 2008/007818) NOVEL USE OF AIMP1 FOR CONTROLLING GLUCOSE LEVEL
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17.01.2008
|
C07K 14/00
|
PCT/KR2006/002753
|
SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION
|
| |
The present invention relates to a novel use of AIMPl for controlling glucose level. More particularly, the present invention relates to a method for controlling glucose level in a subject, and a method for preventing or treating hypoglycemia or disease associated with hypoglycemia in a subject, which comprise administering to a subject in need thereof an effective amount of AIMPl, its functional equivalent or a nucleic acid encoding them. Also, the present invention relates to a composition for controlling glucose level in a subject, and a composition for preventing and treating hypoglycemia or disease associated with hypoglycemia in a subject, which comprises AIMPl, its functional equivalent or a nucleic acid encoding them as an effective...
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