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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 26. |
(WO 2008/016631) CARBON DIOXIDE STIMULATION OF NITRIFICATION IN ACTIVATED SLUDGE REACTORS
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07.02.2008
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C02F 3/00
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PCT/US2007/017166
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UNIVERSITY OF SOUTH FLORIDA
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| |
A method of stimulating nitrification at low SRT by elevating pCO2 during aeration is disclosed. The improvement on solids settling performance when elevated pCO2 was supplied after 2 hours within the React cycle is consistent with the previous results that identified inorganic carbon as a potential remedy to poor settling and bulking sludge problems in activated sludge systems. Elevated pCO2 increases the concentration of carbon dioxide and lowers the pH, which improve nitrification. The specific growth rate of nitrifying bacteria is sensitive to pCO2, pH, and dissolved oxygen (DO). The DO is a function of the aeration rate. Elevating the pCO2 and lowering the aeration rate provides conditions for nitrification rates that are comparable to...
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| 27. |
(WO 2008/016615) METHODS FOR HIGH SENSITIVITY DETECTION OF GENETIC POLYMORPHISMS
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07.02.2008
|
C12Q 1/68
|
PCT/US2007/017128
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
Multiplex PCR-based methods for detecting a variant polynucleotide having a nucleotide sequence differing from the wild-type nucleotide sequence of a nucleic acid molecule, wherein the variant polynucleotide is in a sample containing an excess of the wild-type nucleic acid molecule. The methods are particularly useful for detection of deletions from, or translocations and inversions in, genomic DNA. The susceptibility to, diagnosis of, and progression of a disease clinically related to the occurrence of such polymorphisms in an individual may also be confirmed and monitored using the multiplex PCR-based methods or by detecting RNA fusion transcripts in a sample that correspond to previously identified deletions, translocations or inversions...
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| 28. |
(WO 2008/016606) HIGH REFRACTIVE INDEX CRYSTALLINE COLLOIDAL ARRAYS MATERIALS AND A PROCESS FOR MAKING THE SAME
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07.02.2008
|
B01J 13/02
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PCT/US2007/017115
|
UNIVERSITY OF PITTSBURGH
|
| |
Disclosed are a new composite material and a process for synthesizing highly charged, highly monodisperse, core-shell particles with high refractive index cores, as well as stable, long lasting crystalline colloidal arrays (CCAs) formed thereof. A preferred embodiment of the core particle can be highly monodisperse zinc sulfide (ZnS) particles and a preferred embodiment of the shell can be highly charged polyelectrolytes. The CCAs formed thereof are charge stabilized photonic crystals that shows distinctive first and second order Bragg diffraction peaks whose locations vary over a wide spectral region from UV through visible to IR, with unusually strong intensity and broad band width due to the high index of refraction. These high refractiv...
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| 29. |
(WO 2008/016604) USE OF COLOSTRININ, CONSTITUENT PEPTIDES THEREOF, AND ANALOGS THEREOF AS ANTI-MUTAGENIC AGENTS
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07.02.2008
|
A61K 35/20
|
PCT/US2007/017112
|
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
|
| |
The present invention includes methods of decreasing the mutation frequency in a cell, the method including contacting cells with colostrinin, a constituent peptide thereof, an active analog thereof, or a combination thereof. Mutation frequencies decreased by the present method include spontaneous mutations and mutations induced by reactive oxygen-species (ROS), UVA radiation, UVB radiation, chemical agents and physical agents.
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| 30. |
(WO 2008/016594) PICORNAVIRUS AND USES THEREOF
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07.02.2008
|
A61K 39/00
|
PCT/US2007/017088
|
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
|
| |
The invention is directed to a clade of newly isolated and identified picornaviruses associated with respiratory infection, and isolated nucleic acids sequences and peptides thereof. The invention also relates to antibodies against antigens derived from the picornavirus. The invention also relates to iRNAs which target nucleic acid sequences of the picornavirus. The invention is related to methods for detecting the presence or absence of picornavirus in a subject. The invention is also related to immunogenic compositions for inducing an immune response against picornavirus in a subject.
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| 31. |
(WO 2008/016593) BIOACTIVE DEPSIDE AND ANTHOCYANIN COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
|
07.02.2008
|
A61K 31/235
|
PCT/US2007/017087
|
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
|
| |
Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplemen...
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| 32. |
(WO 2008/016581) IMAGING NEURONAL ACTIVITY USING NONLINEAR PHASE MODULATION AS AN INTRINSIC CONTRAST MECHANISM
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07.02.2008
|
A61B 6/00
|
PCT/US2007/017067
|
DUKE UNIVERSITY
|
| |
Measurements of two photon absorption (TPA) and/or intrinsic non-linear phase modulation such as self-phase modulation (SPM) or cross- phase modulation (XPM) can be used for neuronal imaging, with potential advantages in speed, penetration depth and molecular contrast. Nonlinear optical processes such as SPM and XPM are known to be sensitive to material structure and are significantly altered by neuronal firing. A pulse shaping technique that extracts weak non-linear phase modulation signatures can be extrapolated to high spatial and temporal resolution while retaining the noninvasive character, thus eliminating the requirement for expressed or exogenous contrast agents.
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| 33. |
(WO 2008/016442) A TRUSTED P2P SYSTEM FOR PAID OR OTHER CONTENT DELIVERY
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07.02.2008
|
G06F 15/16
|
PCT/US2007/014815
|
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK
|
| |
A peer-to-peer content delivery system includes trusted auditors to report inappropriate peer behavior. This permits punishment or banishment. The trusted auditors can mimic peer behavior. The trusted auditors can be used in an existing peer-to-peer system, or in a system in which users share content anonymously via layer of inteπnediate nodes. The intermediate nodes can be inhibited from having an entirety of content they help to transfer. Vendors can leverage peer-to-peer transfer capacity and keep the same level of trust of customers as in traditional content distribution models. Infrastructure costs and end-user cost can be lowered. The intermediate nodes can be incentivized to contribute a portion of their transfer capacity, such as v...
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| 34. |
(WO 2008/016414) APPARATUS AND METHOD FOR CONTINUOUS PARTICLE SEPARATION
|
07.02.2008
|
B03B 5/00
|
PCT/US2007/013130
|
THE TRUSTEES OF PRINCETON UNIVERSITY
|
| |
The invention is directed to an apparatus and a method of separating particles, such as cells, from a heterogeneous fluid, such as blood, where the particles have a large range of sizes.
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| |
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| 35. |
(WO 2008/016391) SELF-COMPLEMENTARY PARVOVIRAL VECTORS, AND METHODS FOR MAKING AND USING THE SAME
|
07.02.2008
|
C12N 15/864
|
PCT/US2007/002712
|
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
|
| |
The teachings herein are generally directed to a method of enhancing the genetic stability of parvovirus vectors. The stability of conventional ss or dsAAV vector constructs can be enhanced, for example, to obtain a concurrent increase in vector titer and purity, as well as an improvement in vector safety, due at least in part to the elimination of stuffer DNA from the AAV vector. The method is broadly applicable to all gene transfer/therapy applications, such as those requiring delivery of foreign DNA containing recombinant gene expression cassettes. Such foreign DNA can range, for example, from about 0.2 up to about 5.2 kb in length. The enhanced vector constructs are highly flexible, user-friendly, and can be easily modified (via routine...
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| |
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| 36. |
(WO 2008/016390) CATALYST FOR THE GROWTH OF CARBON SINGLE-WALLED NANOTUBES
|
07.02.2008
|
C23C 16/00
|
PCT/US2007/002586
|
HONDA MOTOR CO., LTD.
|
| |
Methods and processes for synthesizing single-wall carbon nanotubes are provided. A carbon precursor gas is contacted with metal catalysts deposited on a support material. The metal catalysts are preferably nanoparticles having diameters less than about 3 run. The reaction temperature is selected such that it is near the eutectic point of the mixture of metal catalyst particles and carbon. Further, the rate at which hydrocarbons are fed into the reactor is equivalent to the rate at which the hydrocarbons react for given synthesis temperature. The methods produce carbon single-walled nanotubes having longer lengths.
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| |
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| 37. |
(WO 2008/016385) DEACYLASE POLYPEPTIDES, DEACYLASE POLYNUCLEOTIDES, AND METHODS OF USE THEREOF
|
07.02.2008
|
G01N 33/554
|
PCT/US2007/001290
|
THE UNIVERSITY OF WASHINGTON
|
| |
The present invention provides isolated deacylase polypeptides; and deacylase nucleic acids. The present invention further provides methods for identifying inhibitors of a bacterial deacylase and that are candidates for treating a periodontal disease. The present invention further provides antibodies specific for a subject deacylase polypeptide. The present invention further provides diagnostic methods for detecting silent bacterial infections of the gum tissues; diagnostic methods for detecting conditions and disorders that are sequelae of periodontitis; and diagnostic methods for monitoring a patient's response to treatment for a periodontal disease.
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| |
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| 38. |
(WO 2008/016378) METHODS TO TREAT AND/OR PREVENT RADIATION- AND/OR CHEMICAL-INDUCED TOXICITY IN NON-MALIGNANT TISSUE
|
07.02.2008
|
A61K 31/366
|
PCT/US2006/048534
|
SCHERING CORPORATION
|
| |
The present invention relates to methods useful for treating and/ or preventing radiation- and/ or chemical-induced toxicity in non-malignant tissue using a protease activated receptor- 1 (PAR-I) inhibitor. In particular, use of a protease activated receptor- 1 (PAR-I) inhibitor to treat and/or prevent acute and chronic adverse effects of radiation and /or chemical exposure (e.g., to one or more of the following: intestine, lung, oral mucosa, or other organs).
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| |
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| 39. |
(WO 2008/016371) MACROMONOMERS FOR PREPARATION OF DEGRADABLE POLYMERS AND MODEL NETWORKS
|
07.02.2008
|
C08F 120/68
|
PCT/US2006/041270
|
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK
|
| |
The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.
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| |
|
| 40. |
(WO 2008/016345) JOINED CONCENTRIC TUBES
|
07.02.2008
|
H05B 6/10
|
PCT/US2006/029580
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
Tubular objects having two or more concentric layers that have different properties are joined to one another during their manufacture primarily by compressive and friction forces generated by shrinkage during sintering and possibly mechanical interlocking. It is not necessary for the concentric tubes to display adhesive-, chemical- or sinter- bonding to each other in order to achieve a strong bond. This facilitates joining of dissimilar materials, such as ceramics and metals.
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| |
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| 41. |
(WO 2008/016344) THERMIONIC EMITTING METAL INTERCALATED GRAPHITIC NANOFIBERS
|
07.02.2008
|
B32B 9/00
|
PCT/US2006/029539
|
VANDERBILT UNIVERSITY
|
| |
A carbon-based composition comprising graphite carbon nano-fibers intercalated with a metal useful as a thermionic electron emission material.
|
| |
|
| 42. |
(WO 2008/016335) A MICROARRAY SYSTEM AND A PROCESS FOR PRODUCING MICROARRAYS
|
07.02.2008
|
G01N 21/29
|
PCT/SG2007/000232
|
NATIONAL UNIVERSITY OF SINGAPORE
|
| |
A process for making a micro-array. The process comprises the step of depositing a population of microbeads on a substrate having at least one fiducial. The population being comprised of at least two sub-populations, preferably multiple sub-populations, each comprising a known active agent capable of specific binding with at least one target analyte. The said subpopulations are deposited sequentially and at discrete periods of each other. The process also comprises the step of making images of the substrate after deposition of each subpopulation. The images are then compared using the fiducial as a reference to thereby determine the location of each microbead and to identify the subpopulation, and its known active agent, based on difference...
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| |
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| 43. |
(WO 2008/016334) MULTIPLEX ANALYSIS OF NUCLEIC ACIDS
|
07.02.2008
|
C12Q 1/68
|
PCT/SG2007/000231
|
NATIONAL UNIVERSITY OF SINGAPORE
|
| |
There is disclosed a method for identifying target nucleic acids comprising the steps of: contacting a sample containing a plurality of target nucleic acids with at least one series of nucleotide primers under conditions that allow binding of said primers to at least one of said target nucleic acids and labeling of said bound primers with a detectable signal, wherein one member within each series has a lower level of specificity than other members of the series; and measuring said detectable signal of each labeled primer to determine the identity of said target nucleic acids.
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| |
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| 44. |
(WO 2008/016276) TRANSMEMBRANE DELIVERY PEPTIDE AND BIO-MATERIAL COMPRISING THE SAME
|
07.02.2008
|
C07K 7/06
|
PCT/KR2007/003734
|
CHUNG, Ji-Hyung
|
| |
The present invention relates to a transmembrane delivery peptide derived from human in which a target protein may be easily delivered into cells, and a recombinant vector comprising a nucleic acid coding the peptide. More specifically, the present invention relates to the transmembrane delivery peptide having an amino acid sequence described in SEQ ID No. 1 including 11 amino acids of specific sites in amino acid sequences of human G protein alpha 12, and a recombinant vector comprising a nucleic acid coding the same, a transformant prepared by introducing said recombinant vector, and the like. Since transmembrane delivery peptides of the present invention can be efficiently delivered into cells, they may be usefully used for the purposes ...
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| |
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| 45. |
(WO 2008/016247) LINEAR DEPOSITION SOURCES FOR DEPOSITION PROCESSES
|
07.02.2008
|
C23C 14/24
|
PCT/KR2007/003654
|
SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
|
| |
Linear deposition sources are disclosed. In one embodiment, the linear deposition source includes a container accommodating evaporation material and a heater configured to generate heat energy such that vaporized material is discharged uniformly onto a substrate on which a deposition layer is formed. The heater is provided on the container, wherein a portion of the heater positioned at a center portion of the container in the longitudinal direction generates more heat energy than the other portion of the heater. The heater includes a coil configured in a sinusoidal pattern, wherein the curvature pitch or height of the portion of the coil positioned at the center portion of the container in the longitudinal direction is set to be different f...
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| 46. |
(WO 2008/016186) ANTIBODY SPECIFIC TO INTACT HUMAN AUTOTAXIN, METHOD OF SCREENING THE SAME AND METHOD AND REAGENT FOR EXAMINING MALIGNANT LYMPHOMA BY ASSAYING AUTOTAXIN
|
07.02.2008
|
G01N 33/53
|
PCT/JP2007/065573
|
The University of Tokyo
|
| |
It is intended to provide a method of screening an antibody specifically recognizing intact human autotaxin that occurs in the same state as <i>in vivo</i> without being injured, which comprises the following steps: attaching a binding factor capable of capturing candidate antibodies for the antibody as described above to a solid phase; allowing the binding factor to bind to the candidate antibodies for the antibody as described above; treating a system, which has been treated with the above-described candidate antibodies, with intact human autotaxin; and then selecting an antibody specifically recognizing the intact human autotaxin with the use of the binding force to the intact human autotaxin to the above antibody as ...
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| 47. |
(WO 2008/016172) METASTASIS INHIBITOR
|
07.02.2008
|
A61K 31/663
|
PCT/JP2007/065385
|
KURUME UNIVERSITY
|
| |
Disclosed is an agent for inhibiting the bone metastasis and/or the muscle metastasis of a tumor, which is a problem of prognosis of a tumor therapy. Specifically, disclosed is an inhibitor of the metastasis (e.g., bone metastasis and/or muscle metastasis) of a tumor, which comprises a liposomal bisphosphonate-type substance (e.g., clodronate).
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| 48. |
(WO 2008/016163) CROSSLINKED GELATIN GEL MULTILAYERED STRUCTURE, CARRIER FOR BIOACTIVE FACTOR, PREPARATION FOR RELEASE OF BIOACTIVE FACTOR, AND THEIR PRODUCTION METHODS
|
07.02.2008
|
A61K 47/42
|
PCT/JP2007/065323
|
NICHIBAN CO., LTD.
|
| |
Disclosed is a crosslinked gelatin gel multilayered structure having a layered structure comprising multiple crosslinked gelatin gel layers arranged adjacent to one another, wherein each of the crosslinked gelatin gel layers is produced by crosslinking gelatin or a gelatin derivative by irradiation with electron beam in an oxygen-containing atmosphere. Also disclosed is a preparation for releasing a bioactive factor, which comprises the crosslinked gelatin gel multilayered structure and the bioactive factor contained in the crosslinked gelatin gel multilayered structure. Further disclosed are a method for producing the multilayered structure and a method for producing the preparation.
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| |
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| 49. |
(WO 2008/016155) METHOD FOR SCREENING FOR VITAMIN D RECEPTOR LIGAND
|
07.02.2008
|
C12Q 1/68
|
PCT/JP2007/065310
|
THE UNIVERSITY OF TOKYO
|
| |
Disclosed is a method for screening for a compound, comprising the step of detecting the binding between a vitamin D receptor and CDP. Specifically disclosed are: a novel method for the <i>in vitro</i> screening of a compound having a potent bone forming activity and few adverse side-effects; a compound involved in the differentiation of an osteoblast, which can be selected by the screening method; a therapeutic agent for a disease associated with the transcription activity enhanced by a complex of a vitamin D receptor and CDP through the vitamin D receptor, which comprises the compound; and a kit for use in the screening method.
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| |
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| 50. |
(WO 2008/016141) KIF-DERIVED PEPTIDE CAPABLE OF BINDING TO HLA-A24 MOLECULE
|
07.02.2008
|
C12N 15/09
|
PCT/JP2007/065273
|
KURUME UNIVERSITY
|
| |
Disclosed is a peptide derived from a glioma-related antigen, which is useful in specific immunotherapy for a glioma patient. Specifically disclosed is a KIF-derived peptide which can bind to an HLA-A24 molecule and can be recognized by a cell-mediated immunity. Also disclosed is a pharmaceutical composition for treating or preventing glioma, which comprises the peptide.
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