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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 1. |
(WO 2008/017076) ITERATIVE METHODS FOR DOSE REDUCTION AND IMAGE ENHANCEMENT IN TOMOGRAPHY
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07.02.2008
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A61B 6/00
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PCT/US2007/075220
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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A system and method for creating a three dimensional cross sectional image of an object by the reconstruction of its projections that have been iteratively refined through modification in object space and Fourier space is disclosed. The invention provides systems and methods for use with any tomographic imaging system that reconstructs an object from its projections. In one embodiment, the invention presents a method to eliminate interpolations present in conventional tomography. The method has been experimentally shown to provide higher resolution and improved image quality parameters over existing approaches. A primary benefit of the method is radiation dose reduction since the invention can produce an image of a desired quality with a fe...
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| 2. |
(WO 2008/017065) GAS DELIVERY SYSTEM AND METHOD
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07.02.2008
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A61M 16/00
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PCT/US2007/075180
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THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
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| |
A gas delivery system and a method of delivering gas are disclosed. In one such system there is a housing and a displaceable partition. The housing may be divided by the partition into a respirator side and a patient side. The partition may have one or more holes extending through the partition to allow gas to move from one side of the partition to the other side of the partition.
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| 3. |
(WO 2008/017045) SUCCINCT REPRESENTATION OF STATIC PACKET CLASSIFIERS
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07.02.2008
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H04L 12/56
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PCT/US2007/075107
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UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
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A computer-implemented method of classifying packets of data transmitted over a data communications network includes providing a memory-storable packet classifier rule defined by a plurality of filters, each filter uniquely corresponding to a one of a plurality of actions to be taken in transmitting the data packets over the data communications network; and classifying a data packet according to the packet classifier rule by generating at least one supernode trie subject to a predetermined constraint for reducing accesses to a memory in which the packet classifier rule is stored. A system including a combination of hardware and software modules is provided for carrying out the method. A computer-readable storage medium is also provided for ...
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| 4. |
(WO 2008/017031) MICROFLUIDIC PRODUCTION OF MONODISPERSED SUBMICRON EMULSION THROUGH FILTRATION AND SORTING OF SATELLITE DROPS
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07.02.2008
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B07B 13/00
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PCT/US2007/075079
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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| |
Improved systems and methods are provided herein for passively filtering out droplets of different size such as satellite droplets from the generation of primary droplets and use these satellite droplets as the source for monodispersed production of submicron emulsions. The systems and methods described use active flow control to sort droplets of different size into desired collecting zones and use conventional shearing principles, and, as a result, provide 100% filtration of satellite droplets regardless of size differences.
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| 5. |
(WO 2008/017029) DRUG CARRIERS, THEIR SYNTHESIS, AND METHODS OF USE THEREOF
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07.02.2008
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A61K 47/40
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PCT/US2007/075073
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BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
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Drug carriers, methods of synthesizing, and methods of use thereof are provided.
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| 6. |
(WO 2008/017017) THREE-PHASE PARTITIONING METHOD FOR PURIFYING A PROTEIN
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07.02.2008
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A23J 1/00
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PCT/US2007/075047
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RUTGERS, THE STATE UNIVERSITY
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| |
The present invention is a kit and method for purifying a protein of interest.
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| 7. |
(WO 2008/017002) POLYMORPHISMS IN GENES AFFECTING CNS DISORDERS AND USES THEREOF
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07.02.2008
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C12Q 1/68
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PCT/US2007/075010
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THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
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Diagnostic and prognostic methods, compositions, assays, and kits useful for predicting the phenotype of subjects who have, or are at risk of developing, a mental disorder. The methods also include predicting the prognostic outcome of a subject's mental disorder as well as the subject's responsiveness to drug treatments for the mental disorder. The methods and kits include determining the allelic status of polymorphisms in the MAOA, TPH2 and DRD2 genes.
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| 8. |
(WO 2008/016999) FERMENTATION SYSTEM HAVING STRAINER ASSEMBLY
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07.02.2008
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C12M 3/00
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PCT/US2007/075007
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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A fermentation system for production of biogas from solid organic material, the system including at least one fermentation reactor. The fermentation reactor includes a vessel (37) for housing a feed mixture having liquid and solid particles and an outlet port (44), a strainer assembly (33) at the outlet port for filtering processed feed mixture from the vessel, and a biogasification reactor (37) in fluid communication with another fermentation reactor, the other fermentation reactor configured to produce a biomethane. The strainer assembly further includes a mixture driving member (53) positioned in the strainer body (47) adjacent the drain opening (51), the mixture driving member having a driving surface configured to receive the liquid pa...
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| 9. |
(WO 2008/016994) HARNESSING WNT SIGNALING TO RESTRICT HIV REPLICATION
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07.02.2008
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C12N 7/00
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PCT/US2007/075000
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RUSH UNIVERSITY MEDICAL CENTER
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| |
Activation of the Wnt signaling pathway potently restricts HIV replication both in peripheral blood mononuclear cells (PBMCs) and astrocytes. Inducing Wnt signaling, leading to the activation of β-catenin, for example, by the addition of lithium chloride (LiCl) inhibited the replication of a number of HIV isolates in PBMCs. Activating Wnt signaling, either with LiCl or other agents that target this pathway, is an approach to inhibit HIV replication.
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| 10. |
(WO 2008/016987) MULTIPLE PASS SURFACE PLASMON RESONANCE DETECTOR
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07.02.2008
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G01N 21/55
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PCT/US2007/074989
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THE TEXAS A & M UNIVERSITY SYSTEM, A TEXAS STATE AGENCY
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| |
A fiber optic multiple-pass surface plasmon resonance technique provides an increase in the number of passes to any arbitrary number is described. Multiple reflections off a reflective sample surface are achieved in one embodiment using a fiber optic collimator, a reflector, and a second reflector, such as a corner cube prism. An electric field assist may be provided by migrating charged molecules to be detected toward the reflective sample surface. In further embodiments, the filed assist may be used with a single pass surface plasmon resonance technique. In still further embodiments, an electo-optic modulated recirculation loop may be used to increase the number of reflections off the sample surface.
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| 11. |
(WO 2008/016975) COMPOSITIONS AND METHODS FOR THE PROTECTION OF SUBSTRATES FROM HEAT FLUX AND FIRE
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07.02.2008
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C08K 3/22
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PCT/US2007/074974
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RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
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| |
A flame or heat flux protective coating composition, which includes a fiberglass dispersion in silicone. A flame or heat flux protective sheet, which includes fiberglass and silicone in a sheet form, wherein the fiberglass is dispersed in the silicone or the fiberglass is a woven cloth coated with the silicone is also presented. Articles incorporating the flame or heat flux protective coating or sheet form and methods for coating an article with the flame or heat flux protective coating composition are also presented.
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| 12. |
(WO 2008/016928) WINGLESS HOVERING OF MICRO AIR VEHICLE
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07.02.2008
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B64C 39/02
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PCT/US2007/074874
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UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
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| |
Embodiments of the subject invention relate to a Wingless Hovering Micro Air Vehicle (WHOMAV) and its Power Source Unit (PSU). Embodiments can operate at reasonable power levels for hovering and withstanding expected wind gusts. Embodiments of the subject invention can have a diameter less than 15 cm. Embodiments can have one or more smooth (continuous curvature) surface and can be operated using electromagnetic and electrohydrodynamic principles. The wingless design of specific embodiments can allow operation with no rotating or moving components. Additional embodiments can allow active response to the surrounding flow conditions. The issue of low lift to drag ratio and degradation of airfoil efficiency due to the inability of laminar boun...
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| 13. |
(WO 2008/016924) IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN
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07.02.2008
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A61K 48/00
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PCT/US2007/074866
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BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
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| |
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of β-myosin heavy chain (β-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.
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| 14. |
(WO 2008/016914) METHOD AND SYSTEM FOR DEMODULATION OF OPEN-LOOP GPS RADIO OCCULTATION SIGNALS
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07.02.2008
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H04B 7/185
|
PCT/US2007/074840
|
UNIVERSITY CORPORATION FOR ATMOSPHERIC RESEARCH
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| |
Methods and systems for demodulation of open-loop GPS radio occultation signals are provided. An occulted GPS radio signal where the atmosphere-induced modulation on the phase is up to 180 degrees may be recorded by a radio occultation receiver. The radio signal may be concurrently received by a second receiver where the atmosphere-induced phase modulation is below 90 degrees and where the Navigation Data Message (NDM) bit sequence can be readily extracted. The extracted NDM bit sequence may be used to demodulate the occulted GPS radio signal and a 4-quadrant phase extractor may then be used to determine the phase and amplitude of the radio occultation signal. The phase and amplitude modulations after removal of NDM may be used for inversio...
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| 15. |
(WO 2008/016912) SYSTEMS AND METHODS OF ANALYZING TWO DIMENSIONAL GELS
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07.02.2008
|
G01N 33/48
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PCT/US2007/074836
|
CASE WESTERN RESERVE UNIVERSITY
|
| |
Systems and methods of analyzing two dimensional gels are provided, in one embodiment, a method is provided for analyzing a 2-dimensiαnai gel. The method comprises receiving a first image of a gel based on a first protein sample labeled with a first fluorophore, receiving a second image of the ge! based on a second protein sample labeled with a second fluorophore, applying linear normalization to image intensity values of the second image to provide a linear normalized image, and comparing image intensity values of the linear normalized image from image intensity values of the first image to provide a compared image.
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| 16. |
(WO 2008/016911) REPLICATING MELATONIN SIGNALING IN A FETUS, NEWBORN OR SUCKLING INFANT
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07.02.2008
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A61K 31/4045
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PCT/US2007/074834
|
OREGON HEALTH & SCIENCE UNIVERSITY
|
| |
A method for achieving a chronobiologic effect on a circadian rhythm in a human infant or fetus in utero is described. The method involves the administration of melatonin or dose-equivalent melatonin analogue or melatonin receptor agonist to an infant by administering melatonin or dose-equivalent melatonin precursor, melatonin analogue or melatonin receptor agonist to the infant's breast-feeding mother or wet nurse, and to a fetus by administration of melatonin or dose-equivalent melatonin precursor, melatonin analogue or melatonin receptor agonist to the pregnant woman. Alternatives wherein melatonin or dose-equivalent melatonin analogue or melatonin receptor agonist is administered directly to the infant, such as in formula or in expresse...
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| 17. |
(WO 2008/016793) METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR CONTRIBUTING TO THE TREATMENT OF CANCERS
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07.02.2008
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A61K 31/337
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PCT/US2007/074036
|
SPECTRUM PHARMACEUTICALS, INC.
|
| |
Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.
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| 18. |
(WO 2008/016759) ANTI-AGING COMPOSITIONS COMPRISING MENYANTHES TRIFOLIATA LEAF EXTRACTS AND METHODS OF USE THEREOF
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07.02.2008
|
A01N 65/00
|
PCT/US2007/072823
|
ELC MANAGEMENT LLC
|
| |
An anti-aging composition comprising a skin-beneficial amount of actives identified in Menyanthes trifoliata leaf, wherein the actives are inhibitors of one or more of MMP-1, 2 and 9 and/or scavengers of peroxynitrite. Also disclosed are methods of using such a composition, which include treating the skin for signs of chronological or pre-mature aging.
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| 19. |
(WO 2008/016707) USE OF IL-6 IN THE DIAGNOSIS AND TREATMENT OF NEUROINFLAMMATORY CONDITIONS
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07.02.2008
|
C12P 19/12
|
PCT/US2007/017376
|
THE JOHNS HOPKINS UNIVERSITY
|
| |
The invention features compositions and methods that are useful for the diagnosis and treatment of neuroinflammatory disorders (e.g., transverse myelitis, multiple sclerosis, optic neuritis, neuromyelitis optica).
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| 20. |
(WO 2008/016703) MULTIPLEXED MICROFLUIDIC VALVE ACTIVATOR
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07.02.2008
|
F16K 31/12
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PCT/US2007/017352
|
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
|
| |
Microfluidics devices include a mulitplexed hydraulic valve activation device The actuator of a microfluidcs device houses a control channel to cause a non-volatile and low-material permeability liquid and an actuator The actuator is in communication with a control channel The control channel communicates with a fluid channel, such that fluid moves through the control channel and compresses the fluid channel The action of compressing the fluidic channel may move fluid through the fluid channel The device may also include a piston in communication with a control channel and an actuator The device can be coupled to a computer system, control software, imaging devices, an incubator, or a cell handling system.
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| 21. |
(WO 2008/016693) METHOD FOR DETERMINING THE GENETIC BASIS FOR PHYSIOLOGICAL CHANGES IN ORGANISMS
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07.02.2008
|
C12Q 1/68
|
PCT/US2007/017283
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
The present invention provides a method for discovering the basis of changes in the observable properties of organisms by subjecting an organism to selection. Individual organisms with observable differences will thus become more prevalent in a population during selection. The basis for the differences are then determined by identifying genetic differences among the individual organisms and the original organism, followed by evaluation of the effects of each genetic difference either alone or in combination by using site-directed mutagenesis followed by observation of the effects.
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| 22. |
(WO 2008/016682) ARYL VINYL SULFIDES, SULFONES, SULFOXIDES AND SULFONAMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF
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07.02.2008
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A61K 31/33
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PCT/US2007/017266
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TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
|
| |
Compounds useful as antiproliferative agents, including, for example, anticancer agents, according to formula (I): wherein Ar1, Ar2, D, G, formula (a), m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, synthetic processes, and intermediates useful in such processes are provided.
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| 23. |
(WO 2008/016664) COMPOSITIONS AND METHODS FOR TREATING CANCER WITH DACARBAZINE NANOEMULSIONS
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07.02.2008
|
A61K 9/66
|
PCT/US2007/017228
|
UNIVERSITY OF MASSACHUSETTS LOWELL
|
| |
A uniform microfluidized nanoemulsion is disclosed containing an anti-cancer agent, such as dacarbazine. The microfluidized nanoemulsion improves the combination's cell membrane permeability by at least four-fold over conventional nanoemulsion compositions, which significantly increases the intracellular concentration of anti-cancer agents. As a nanoemulsion, dacarbazine has a greater anti-cancer efficacy than when applied as a free solution.
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| 24. |
(WO 2008/016659) AGENTS FOR TREATING NEURODEGENERATIVE DISEASES
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07.02.2008
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A61K 31/496
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PCT/US2007/017221
|
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
|
| |
The present invention relates to compounds effective in preventing neuronal cell death, which may be used in the treatment of neurodegenerative diseases. It is based, at least in part, on the discovery that particular compounds were effective in preventing neuronal death in model systems of Huntington's Disease.
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| 25. |
(WO 2008/016632) DEOXYBENZOIN-BASED ANTI-FLAMMABLE POLYPHOSPHONATE AND POLY(ARYLATE-PHOSPHONATE) COPOLYMER COMPOUNDS, COMPOSITIONS AND RELATED METHODS OF USE
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07.02.2008
|
C08K 3/32
|
PCT/US2007/017167
|
UNIVERSITY OF MASSACHUSETTS
|
| |
Deoxybenzoin-phosphonate and other copolymer compounds, compositions and related methods.
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