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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 51. |
(WO 2008/010984) ACRIDINE ACTIVATION OF P53 AND USES THEREOF
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24.01.2008
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C07D 413/12
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PCT/US2007/016122
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
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| |
This invention relates to the stabilization of p53 in cells, thereby inducing eitrher cell cycle arrest or apoptosis or both and the consequence of such stabilization on the treatment of cancer. Specifically, the use of acridine and its derivatives in stabilizing p53 through blockage of its ubiquitation, thereby inducing cell cycle arrest or apoptosis in a cell; and the use of these compounds in the treatment of cancer.
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| 52. |
(WO 2008/010975) EARLY DETECTION AND PROGNOSIS OF COLON CANCERS
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24.01.2008
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C12Q 1/68
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PCT/US2007/016104
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THE JOHNS HOPKINS UNIVERSITY
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| |
A genome wide microarray gene expression approach for human colorectal cancer cells was used to identify hundreds of hypermethylated genes for colon cancer. We compared isogenic cells altered pharmacologically versus genetically to induce genomic demethylation, to pinpoint genes activated by DNA demethylation, but not by inhibition of class I and II histone deacetylases (HDACs). We achieve an 82% success rate in predicting genes with densely hypermethylated CpG islands and complete gene silencing. The genes are similarly hypermethylated in primary tumors and have previously undetected tumor suppressor functions. The genes can be used diagnostically to detect cancer, pre-cancer, and likelihood of developing cancer.
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| 53. |
(WO 2008/010959) BEAM ABLATION LITHOGRAPHY
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24.01.2008
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H01L 21/00
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PCT/US2007/016006
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
|
| |
Provided are beam ablation lithography methods capable of removing and manipulating material at the nanoscale. Also provided are nanoscale devices, nanogap field effect transistors, nano-wires, nano-crystals and artificial atoms made using the disclosed methods.
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| 54. |
(WO 2008/010953) PYRIDINONE DIKETO ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY
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24.01.2008
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A61K 31/4412
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PCT/US2007/015981
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UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
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| |
A new class of diketo acids constructed on pyridinone scaffolds, designed as inhibitors of HTV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents, especially other anti-HIV compounds (including other anti-HIV integrase agents), which can be used to create combination anti-HIV cocktails. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described. C...
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| 55. |
(WO 2008/010930) HIV-1 PEPTIDES, NUCLEIC ACIDS, AND COMPOSITIONS, AND USES THEREOF
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24.01.2008
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C07K 5/00
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PCT/US2007/015703
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UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
|
| |
This invention features polypeptides, variants thereof, and fragments thereof useful in eliciting an immune response (e.g., neutralizing antibodies) against a broad spectrum of HIV-I isolates. The polypeptides, variants, and fragments include a portion of the gpl20 V2 domain of HIV-I. The polypeptides, variants, and fragments display an epitope that is recognized by at least one antibody which neutralizes at least one HIV-I primary isolate. This invention also features nucleic acid sequences encoding those polypeptides. In addition, the invention provides methods of screening for inhibitors of HIV-I entry into cells, as well as methods of treatment using the inhibitors.
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| 56. |
(WO 2008/010902) REGULATION OF TLR SIGNALING BY COMPLEMENT
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24.01.2008
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C07K 14/00
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PCT/US2007/015105
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
|
| |
This invention provides methods of inducing the production of pro-inflammatory cytokines by activating a Toll like Receptor (TLR) and the complement system. This invention further provides vaccines that contain compounds that activate a Toll like Receptor (TLR) and the complement system.
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| 57. |
(WO 2008/010864) MODIFIED ADENOVIRUS HEXON PROTEIN AND USES THEREOF
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24.01.2008
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A61K 39/12
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PCT/US2007/010347
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
|
| |
The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The modified adenovirus has a capsid comprising a hexon protein with a deletion in hypervariable region 1 and/or hypervariable region 4 of the hexon and an insert of an exogenous molecule therein.
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| 58. |
(WO 2008/010859) PLANT SUPEROXIDE DISMUTASE EXPRESSION RESISTANT TO MICRO-RNA REGULATION
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24.01.2008
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C12N 15/52
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PCT/US2007/008680
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
This invention provides variant sequences to miR398 targets in copper/zinc superoxide dismutase (CSD) genes resulting in resistance to down regulation of the CSD by the miR398.
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| 59. |
(WO 2008/010852) COMPOSITION AND METHOD OF TREATING HEARING LOSS
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24.01.2008
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H04R 29/00
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PCT/US2007/001422
|
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
|
| |
A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.
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| 60. |
(WO 2008/010844) COMPOSITIONS AND METHODS FOR THE DETECTION OF CHEMICAL WARFARE AGENTS
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24.01.2008
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G01N 31/00
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PCT/US2006/061865
|
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
|
| |
Compositions for detection of chemical warfare agents that comprise oximate anion reactive sites and fluorophore cores. Methods for detecting a chemical warfare agents that comprise providing a detector molecule comprising an oximate anion reactive site and a fluorophore core and detecting fluorescence from the detector molecule. Methods for enhancing the reactivity of an oximate nucleophile that comprise introducing an oxime into an aprotic solvent and deprotonating the oxime to form the oximate nucleophile with a base that creates noncoordinating anions.
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| 61. |
(WO 2008/010843) ASSESSING THE TOXIC POTENTIAL OF NANOMATERIALS
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24.01.2008
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G01N 33/50
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PCT/US2006/061685
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
A method based is provided for determining the toxicity of engineered nanomaterials (NM). The method comprises in vitro assays for oxidative stress associated with exposure to engineered NM, which comprise assays for: reactive oxygen species production; phase Il and glutathione antioxidant molecule expression; activation of MAP and NF-kappa B kinase signaling cascades; production of cytokines, chemokines and adhesion molecules; mitochondrial perturbation and apopotosis; and cellular uptake and subcellular localization of the NM. The method further comprises in vivo assays for oxidative stress in subjects exposed to NM.
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| 62. |
(WO 2008/010837) NONCOMPETITIVE IMMUNOASSAYS TO DETECT SMALL MOLECULES
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24.01.2008
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G01N 33/53
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PCT/US2006/048123
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
The present invention provides noncompetitive immunoassays to detect small molecules.
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| 63. |
(WO 2008/010830) MECHANISM FOR BIAXIAL ROTATION OF A WING AND VEHICLE CONTAINING SUCH MECHANISM
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24.01.2008
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B64C 33/02
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PCT/US2006/043294
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UNIVERSITY OF DELAWARE TECHNOLOGY CORPORATION
|
| |
A vehicle with wings and a mechanism for causing a flapping motion in wings. Each wing structure comprises a wing and a wing spar coupled to a follower via a resilient member. Each wing carrier is pivotally connected to the body and is configured to restrain lateral movement and permit rotation of the wing spar about a feathering axis. A biasing member provides torsional bias to each wing spar. A linkage, driven by an actuator, transmits cyclic motion that rotates the wing carrier about a flapping axis, which moves the follower along a follower path. A guide attached to the vehicle body lies in the path of each follower, and the follower and guide are shaped such that each wing spar has a first rotational position about its axis along a fir...
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| 64. |
(WO 2008/010824) IMPROVED CATALYSTS FOR FUEL CELL APPLICATIONS USING ELECTROLESS DEPOSITION
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24.01.2008
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C23C 18/16
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PCT/US2006/035767
|
UNIVERSITY OF SOUTH CAROLINA
|
| |
The present disclosure is directed to a process for electroless deposition of metal atoms on an electrode. The process includes treating a carbon-containing support by contacting the carbon-containing support with a treatment, impregnating the carbon- containing support with a precursor metal component to form seed sites on the carbon- containing support, and depositing metal atoms on the seed sites through electroless deposition by contacting the carbon-containing support with a metal salt and a reducing agent.
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| 65. |
(WO 2008/010788) COMPOSITIONS AND METHODS FOR MAKING AND USING NANOEMULSIONS
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24.01.2008
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A61K 9/00
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PCT/US2006/026918
|
UNIVERSITY OF MASSACHUSETTS LOWELL
|
| |
The present invention discloses an improved nanoemulsion comprising a uniform and discrete range of very small particle nano-sized diameters. This uniformity results in improved bioavailability of incorporated compounds (i.e., pharmaceuticals or nutraceuticals) as reflected in various pharmacokinetic parameters including, but not limited to, decreased Tmax, increased Cmax, and increased AUC. The improved method of making these uniform nanoemulsions utilizes microfluidization which differs in both process and mechanics when compared to conventional milling and grinding techniques used to generate nanoparticulate compositions. Further, the improvement results, in part, from a novel step of mixing a substantially soluble compound into a heated...
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| 66. |
(WO 2008/010777) A MULTI-BEAM ION/ELECTRON SPECTRA-MICROSCOPE
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24.01.2008
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H01J 37/26
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PCT/SG2007/000218
|
NATIONAL UNIVERSITY OF SINGAPORE
|
| |
This invention is a multi-beam charged particle instrument that can simultaneously focus electrons and a variety of positive and negative ions, such as Gallium, Oxygen and Cesium ions, onto the same material target. In addition, the instrument has provision to simultaneously capture the spectrum of both secondary electrons and ions. The highly dispersive, high resolution mass spectrometer portion of the instrument is expected to detect and identify secondary ion species across the entire range of the periodic table, and also record a portion of their emitted energy spectrum. The electron energy spectrometer part of the instrument is designed to acquire the entire range of scattered electrons, from the low energy secondary electrons through ...
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| |
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| 67. |
(WO 2008/010687) METHOD FOR SELECTIVE BINDING, SEPARATION OR PURIFICATION OF PROTEINS USING MAGNETIC NANOPARTICLES
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24.01.2008
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B82B 3/00
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PCT/KR2007/003519
|
SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION
|
| |
The present invention relates to a method for selective binding, separation or purification of proteins using magnetic nanoparticles. More specifically, the present invention provides an easier, faster, and more economical method for the separation of specific proteins compared to the conventional method for metal-ion affinity chromatography. Furthermore, the present invention relates to a method for selective binding, separation, or purification of a specific protein using magnetic nanoparticle, which comprises: binding a magnetic nanoparticle which includes a transition metal such as iron, manganese, nickel, cobalt, zinc, etc. or ions thereof, to a specific protein contained in a biological mixture; separating said specific protein bound ...
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| |
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| 68. |
(WO 2008/010682) A HOLLOW TYPE MICRONEEDLE AND METHODS FOR PREPARING IT
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24.01.2008
|
A61M 37/00
|
PCT/KR2007/003507
|
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
|
| |
Disclosed herein are hollow microneedles and a fabrication method thereof. The microneedles are small in diameter and are long and hard enough to pass through the stratum corneum. Therefore, the hollow microneedle of the present invention can be used in blood sampling or drug injection through the skin.
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| |
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| 69. |
(WO 2008/010681) A SOLID TYPE MICRONEEDLE AND METHODS FOR PREPARING IT
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24.01.2008
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A61M 37/00
|
PCT/KR2007/003506
|
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
|
| |
Disclosed herein are biodegradable solid microneedles and a fabrication method thereof. The microneedles are small in diameter and are long and hard enough to pass through the stratum corneum. Thus, the biodegradable solid microneedles can be used for painless transdermal drug delivery, the detection of biological samples such as blood, and biopsy.
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| 70. |
(WO 2008/010648) MATCHING METHOD FOR MULTIPLE STUCK-AT FAULTS DIAGNOSIS
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24.01.2008
|
H01L 21/66
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PCT/KR2007/003127
|
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
|
| |
Provided is a matching method of diagnosing multiple stuck-at faults, which can accurately diagnose the multiple stuck-at faults using a single stuck-at fault simulator. The matching method includes calculating scores of candidate faults; generating a vectorwise intersection table; and determining a final set of candidate faults. The operations of calculating scores of the candidate faults and generating the vectorwise intersection table are serially performed during the simulation. The faults are classified as a vectorwise intersection, an intersection, a misprediction, a nonprediction, and a no error, and the calculation of the scores is performed for each of the classifications.
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| 71. |
(WO 2008/010637) COMPOSITION FOR ATTENUATING NEUROPATHIC PAIN COMPRISING A RECOMBINANT VECTOR EXPRESSING GAD65
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24.01.2008
|
A61K 48/00
|
PCT/KR2007/001508
|
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
|
| |
Provided is a pharmaceutical composition for attenuation of neuropathic pain comprising a GAD65-expressing recombinant vector. Direct introduction of the pharmaceutical composition of the present invention into a sciatic nerve leads to immediate therapeutic effects on peripheral neuropathic pain with a sustained and constant duration for several months. Therefore, the composition of the present invention is effective for the alleviation of peripheral neuropathic pain.
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| 72. |
(WO 2008/010632) ELECTROSTATIC CHUCK WITH HIGH-RESISTIVITY CERAMIC COATING MATERIALS
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24.01.2008
|
H01L 21/683
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PCT/KR2007/000855
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UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION CHUNGNAM NATIONAL UNIVERSITY
|
| |
The present invention relates to a method of manufacturing an electrostatic chuck used in stably fixing a wafer or glass substrate in a semiconductor/display panel manufacturing equipment. A core portion of the electrostatic chuck is formed through thermally- sprayed coating, and an Al2O3-YAG coating material with superior durability is applied to a portion in which electrical insulation and dielectric characteristics are required for the purpose of the increase of an adhesive strength, the uniformity of an adhesive force, the reduction of attaching/detaching time and the expansion of a life span.
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| 73. |
(WO 2008/010537) PLASMA PROCESSING DEVICE, PLASMA PROCESSING METHOD, AND PLASMA SURFACE PROCESSING METHOD
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24.01.2008
|
H05H 1/46
|
PCT/JP2007/064219
|
National University Corporation Nagoya University
|
| |
[PROBLEMS] To generate plasma inside a tube of a small opening diameter and perform plasma processing inside the tube. [MEANS FOR SOLVING PROBLEMS] A plasma processing device (2) is formed by a chamber (4) and a microwave generation device (6). A microwave is introduced into the chamber via a quartz tube (16). A tube holder (18) is arranged inside the quartz tube (16). Two holes are arranged in the side surface of the tube holders (18). A tube (20) of a micro opening diameter is fixed to the end of the tube holder (18).
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| 74. |
(WO 2008/010532) COMPOUND OR SALT THEREOF, PROCESSES FOR PRODUCING THESE, AROMATIC AZO COMPOUNDS, AND FLUORESCENT MATERIAL
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24.01.2008
|
C07F 5/02
|
PCT/JP2007/064213
|
The University of Tokyo
|
| |
A series of aromatic azo compounds (azoarene derivatives) was found to have a high fluorescence quantum yield. In particular, [2-(4-methoxyphenylazo)phenyl]bis(pentafluorophenyl)borane, which is an azobenzene derivative, had a fluorescence quantum yield in a room-temperature solution of 0.76, which was the highest in history. Various investigations on azobenzene derivatives have been made and many synthesis techniques have been established. A fluorescent material is provided which is useful because it has the intact advantage of the variety and simplicity of azobenzene derivative synthesis methods and because of the ease of regulating fluorescence wavelengths, etc. The compounds have excellent properties and are hence expected to be used in...
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| 75. |
(WO 2008/010520) SHOWER PLATE, METHOD FOR PRODUCING THE SAME, PLASMA PROCESSING APPARATUS USING THE SHOWER PLATE, PLASMA PROCESSING METHOD, AND METHOD FOR MANUFACTURING ELECTRONIC DEVICE
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24.01.2008
|
H05H 1/46
|
PCT/JP2007/064191
|
TOKYO ELECTRON LIMITED
|
| |
Disclosed is a shower plate which enables efficient plasma excitation, while completely preventing backflow of plasma. Specifically disclosed is a shower plate (105) which is arranged in a process chamber (102) of a plasma processing apparatus and comprises a plurality of gas discharging holes (113a) for discharging a plasma excitation gas for generating a plasma in the process chamber (102). In this shower plate (105), the aspect ratio between the length and the diameter of the gas discharging holes (length/diameter) is not less than 20. The gas discharging holes (113a) are formed in a ceramic member (113) which is separate from the shower plate (106), and the ceramic member (113) is fitted into a vertical hole (105) which is formed in the...
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