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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 1. |
(WO 2007/134328) GELDANAMYCINS AND THEIR QUINONE MOIETIES INHIBIT CANCER BY ACTING ON MITOCHONDRIAL VOLTAGE-DEPENDENT ANION CHANNEL (VDAC) PROTEIN
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22.11.2007
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C07D 345/00
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PCT/US2007/068988
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VAN ANDEL RESEARCH INSTITUTE
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Derivatives of geldanamycin (GA), a benzoquinone ansamycin antibiotic, are in clinical trials as anticancer drugs. While, at nanomolar concentrations, these drugs are known to target HSP90 chaperone activity, second anticancer activity that inhibits HGF/SF-mediated tumor cell invasion at nanomolar concentrations has been found. Disclosed is the identification of the outer membrane mitochondrial voltage-dependent anion channel (VDAC) protein, a component of the permeability transition pore (PTP), as a novel GA binding protein and a demonstration that GA inhibits membrane potential at picomolar levels. Uubiquinone 0 and decyl-ubiquinone, known benzoquinone inhibitors of mitochondrial PTP function like GA, inhibit HGF/SF induced urokinase (uPA...
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| 2. |
(WO 2007/134304) METHODS AND COMPOSITIONS FOR CONTROLLED AND SUSTAINED PRODUCTION AND DELIVERY OF PEROXIDES
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22.11.2007
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C01D 1/32
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PCT/US2007/068910
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VIRGINIA COMMONWEALTH UNIVERSITY
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Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient's body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, H2O2 or inorganic peroxides from peroxide adducts with movement of these moieties across a selectively permeable barrier into, preferab...
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| 3. |
(WO 2007/134285) π-CONJUGATED HEAVY-METAL POLYMERS PARTICULARLY SUITED TO HYDROPONIC APPLICATIONS
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22.11.2007
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H05B 33/14
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PCT/US2007/068872
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UNIVERSITY OF UTAH
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A class of organic light-emitting diodes (OLEDs) emit light tailored to the absorption spectra of growing plants. Upon photoexcitation, the OLEDs generate light in both the blue-green and red regions of the visible spectrum. A heavy metal atom present in the π-conjugated polymer chain (such as platinum and/or iridium) acts via the spin-orbit coupling mechanism to cause an enhancement of the ratio of fluorescent to phosphorescent emission to be of approximately equal strength. These two emission bands overlap the absorption spectra of common plants grown under hydroponic conditions.
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| 4. |
(WO 2007/134280) π-CONJUGATED HEAVY-METAL POLYMERS FOR ORGANIC WHITE-LIGHT-EMITTING DIODES
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22.11.2007
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H01L 51/00
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PCT/US2007/068858
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UNIVERSITY OF UTAH
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| |
A polymer mixture emits a broad spectrum of visible light that appears white or near-white in the aggregate. The polymer mixture comprises two (or more) components in the active layer. A heavy atom, such as platinum and/or iridium, present in the backbone of the mixture acts via a spin-orbit coupling mechanism to cause the ratio of fluorescent to phosphorescent light emission bands to be of approximately equal strength. These two broad emissions overlap, resulting in an emission spectrum that appears to the eye to be white.
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| 5. |
(WO 2007/134254) SURVEYING AND MONITORING RESPIRATORY TRACT VIRAL COMMUNITIES USING UNCULTURED HUMAN SPUTUM SAMPLES
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22.11.2007
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C12Q 1/70
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PCT/US2007/068811
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SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION
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The invention provides compositions (e.g., kits) and methods for surveying and characterizing the presence of viral, bacterial and/or phage nucleic acid, including the complete viral and/or phage nucleic acid (e.g., DNA and/or RNA) population found in an individual, e.g., a human or other animal, including the complete viral, bacterial and/or phage pulmonary population, using the individual's sputum, for example, by using a human sputum sample.
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| 6. |
(WO 2007/134241) NASAL DELIVERY OF THERAPEUTIC AGENTS USING TIGHT JUNCTION AGONISTS
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22.11.2007
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A61K 38/08
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PCT/US2007/068792
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UNIVERSITY OF MARYLAND BALTIMORE
|
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The invention relates to a therapeutic composition comprising a therapeutically effective amount of one or more therapeutic agents and a nasal mucosa absorption-enhancing amount of one or more tight junction agonists. The invention further relates to a method of treating a subject comprising intranasally administering the composition of the invention to the subject.
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| 7. |
(WO 2007/134236) IMAGING AGENTS AND METHODS
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22.11.2007
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A61K 31/404
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PCT/US2007/068783
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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The disclosure includes a composition including a poly(L-glutamic acid) and a NIRF dye. It also includes a method including providing to a plurality of cells an imaging agent including poly(L-glutamic acid), a NIRF dye and then imaging the cells to detect the imaging agent. It further includes a dual functional contrast agent including an MRI agent conjugated with an optical imaging agent. A method of detecting cancer is provided including injecting a dual functional contrast agent into a patient and performing both an MRI and an optical scan. The presence of the agent may indicate cancer. A method of detecting cancer by injecting PG-DTPA-Gd-NIR813 into a patient, then detecting the presence or absence of Gd in a cell or tissue of the patie...
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| 8. |
(WO 2007/134229) FUNGUS-SPECIFIC IMAGING AGENTS
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22.11.2007
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A01N 37/18
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PCT/US2007/068766
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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The disclosure relates to an imaging composition including a fungus-specific peptide and an imaging material. Another imaging composition includes a fungus-specific peptide and a chelator able to chelate a radionuclide. The disclosure also provides to a method of detecting a fungal infection. The method includes administering an imaging agent to a patient. The imaging agent comprises a fungus-specific peptide and an imaging material. Then one may detect the imaging agent in the patient. Detecting retained imaging agent in a tissue or organ indicates fungal infection of the tissue or organ.
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| 9. |
(WO 2007/134220) A GENERAL METHOD FOR GENERATING HUMAN ANTIBODY RESPONSES IN VITRO
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22.11.2007
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C12N 5/00
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PCT/US2007/068752
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UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE
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| |
This invention relates to an in vitro method of producing antigen specific B cells and antibodies that provides for the capture of an entire primary human antibody repertoire for any foreign antigen, allows for screening large numbers of immunogen/adjuvant combinations, and permits the isolation of human monoclonal antibodies on demand thereby obviating the need to immunize humans with the target antigen.
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| 10. |
(WO 2007/134191) DETECTING MULTIPLE TYPES OF LEUKOCYTES
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22.11.2007
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C12M 1/34
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PCT/US2007/068704
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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Methods, systems, and apparatus for detecting multiple types of leukocytes in a blood sample material. A fluid or gas sample may pass through a sieve-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the relative distribution of multiple types of white blood cells in the sample.
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| 11. |
(WO 2007/134190) METHODS AND APPARATUS OF THREE DIMENSIONAL CARDIAC ELECTROPHYSIOLOGICAL IMAGING
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22.11.2007
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A61B 5/042
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PCT/US2007/068702
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REGENTS OF THE UNIVERSITY OF MINNESOTA
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Generating a three-dimensional representation of cardiac electrical activity within a subject's heart includes collecting, from a catheter having a distal portion that includes sensors that sense electrical activity and which catheter distal portion is positioned within a cardiac chamber of a subject, data for electrical activity sensed by the catheter distal portion while positioned within the chamber of the heart. The method also includes executing an imaging algorithm on the collected electrical activity data to generate a three-dimensional representation of cardiac electrical activity within a volume of the subject including all or a portion of the subject's heart. The method further includes displaying the imaged three-dimensional card...
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| 12. |
(WO 2007/134189) DETECTING TUMOR BIOMARKER IN ORAL CANCER
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22.11.2007
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C12Q 1/00
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PCT/US2007/068701
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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Methods and device for detecting the presence of tumor biomarkers in oral squamous cell carcinoma. A membrane based cell capture device allows deliver of cell samples and reagents to the membrane.
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| 13. |
(WO 2007/134167) COMPUTATIONAL ANALYSIS OF THE SYNERGY AMONG MULTIPLE INTERACTING FACTORS
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22.11.2007
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G01N 33/48
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PCT/US2007/068666
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THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
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Systems and methods for selecting factors from a data set of measurements are provided. The measurements include values of factors and/or outcomes. Two or more factors that are jointly associated with one or more outcomes from the data set are identified. Each of the two or more factors are analyzed to determine at least one cooperative interaction among the factors with respect to an outcome. The two or more factors can be a module of factors.
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| 14. |
(WO 2007/134162) INVOLVEMENT OF A NOVEL NUCLEAR-ENCODED MITOCHONDRIAL POLY(A) POLYMERASE PAPD1 IN EXTREME OBESITY-RELATED PHENOTYPES IN MAMMALS
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22.11.2007
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C12Q 1/68
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PCT/US2007/068656
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WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION
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| |
Aspects of the present invention also provide novel compositions and methods based on novel PAPDl single nucleotide polymorphisms selected from the group consisting of AAFC02034082A:g.9224G>A, g.9330A>C, g.9367G>C, g.9419A>C, g.9435T>G, g.9409[(G)4]+[(G)5], g.l0084T>C, g.lO228G>T, c.10326C>T and c.lO364A>G, which may provide novel markers for intramuscular fat deposition. Additional aspects provide for novel methods which may comprise marker-assisted selection or marker-assisted management to improve intramuscular fat deposition in cattle.
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| 15. |
(WO 2007/134142) METHODS AND COMPOSITIONS FOR IDENTIFYING AND USING P21-REGULATED PROTEINS
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22.11.2007
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A61K 48/00
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PCT/US2007/068619
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UNIVERSITY COLLEGE DUBLIN
|
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This disclosure identifies p21-regulated proteins that may be used to induce anti- apoptotic and/or mitogenic cellular effects, both paracrine and within the p21-expressing cell itself. Three proteins released from HT- 1080 human fibrosarcoma cells displaying inducible p21 expression were identified; β-2-microglobulin, cystatin C, and pro-platelet basic protein. The disclosure also provides therapeutic compositions, methods for using, and methods for identifying p21-regulated proteins.
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| 16. |
(WO 2007/134141) APPARATUS AND METHOD FOR GROWING BIOLOGICAL ORGANISMS FOR FUEL AND OTHER PURPOSES
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22.11.2007
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C12M 1/00
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PCT/US2007/068618
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OHIO UNIVERSITY
|
| |
A bioreactor apparatus (10) in which a container (20) has sidewalls (22), a floor (24) and a ceiling (26) defining a chamber that contain a slurry of water, nutrients and photosynthetic microorganisms. A plurality of optical fibers (80) each of which has a first end disposed outside the chamber and a second end in the mixture. A light collector (70) spaced from the container has light incident on it and focuses the light onto the first ends of the plurality of optical fibers, thereby permitting the light to be conveyed into the mixture to promote photosynthesis. At least one nozzle (30) is in fluid communication with a source of gas, such as exhaust from a fossil-fuel burning power plant containing carbon dioxide. The nozzle is disposed in ...
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| 17. |
(WO 2007/134127) AGENTS FOR IMAGING APOPTOSIS
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22.11.2007
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A61K 38/00
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PCT/US2007/068596
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
|
| |
Compositions, and methods of using such compositions, having the following Formula (I) or salt, ester, or hydrate thereof, wherein R1 is Asp-Glu peptide, tert-butyloxycarbonyl, methoxyphenylacetyl, bromomethoxyphenylacetyl, fluoromethoxyphenylacetyl, (methylmethoxyphenyl)acetyl, or iodomethoxyphenylacetyl; R2 is valine (with or without protecting groups), aspartate (with or without protecting groups), t-Butyl, hydrogen, aniline, aromatic molecules, tert-butyloxycarbonyl, or fluorenyl-methoxy-carbonyl; and R3 is p- nitroaniline, 7-amino-4-methylcoumarin, fluoroethylamine, l-amino-4-fluoromethyl- cyclohexane, l-amino-4-fluoroethyl-cyclohexane, aniline, p-fluoroaniline, p- fluoromethylaniline, p-fluorobenzylamine, p-fluoromethylbenzylamine, 4-...
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| 18. |
(WO 2007/134122) PLANT ARTIFICIAL CHROMOSOME PLATFORMS VIA TELOMERE TRUNCATION
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22.11.2007
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C12N 15/82
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PCT/US2007/068589
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THE CURATORS OF THE UNIVERSITY OF MISSOURI
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The invention provides engineered plant minichromosomes generated by telomere mediated truncation of native chromosomes. These minichromosomes are faithfully transmitted from one generation to the next and provide an ideal platform for breeding genes into desired plant varieties with out problems, such as linkage drag, associated with standard breeding methods.
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| 19. |
(WO 2007/134120) MICROFLUIDIC DEVICE FOR FORMING MONODISPERSE LIPOPLEXES
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22.11.2007
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A61K 9/127
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PCT/US2007/068587
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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A method for forming monodisperse lipoplex assemblies includes providing a microfluidic device having a main microfluidic channel coupled to first and second reactant inlet channels. The first inlet channel is used to deliver a cationic lipid to the main channel while the second channel is used to deliver a nucleic acid. A droplet generation zone is provided in the main channel at the intersection of first and second carrier channels that contain a hydrophobic fluid. The cationic lipid, nucleic acid, and the hydrophobic fluid are then pumped through the device. In the droplet generation zone, shear force from the hydrophobic fluid pinches off droplets. The cationic lipid and nucleic acid are mixed in the generated droplets as the droplets m...
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| 20. |
(WO 2007/134117) DETECTING SINGLE AMINO ACID POLYMORPHISMS BY ISOTOPIC LABELING AND MASS SPECTROMETRY
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22.11.2007
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G01N 1/00
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PCT/US2007/068584
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INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
|
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A combination of split-field drift tube/mass spectrometry and isotopic labeling techniques is described for identifying single amino acid polymorphisms (SAAPs).
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| 21. |
(WO 2007/134094) HIGH FLUX AND SELECTIVITY SAPO-34 MEMBRANES FOR CO2/CH4 SEPARATIONS
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22.11.2007
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C07C 7/144
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PCT/US2007/068542
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THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
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SAPO-34 membranes and methods for their preparation and use are described. The SAPO-34 membranes are prepared by contacting at least one surface of a porous membrane support with a synthesis gel. The Si/AI ratio of the synthesis gel can be from 0.3 to 0.15. SAPO-34 crystals are optionally applied to the surface of the support prior to synthesis. A layer of SAPO-34 crystals is formed on at least one surface of the support. SAPO-34 crystals may also form in the pores of the support. SAPO-34 membranes of the invention can have improved selectivity for certain gas mixtures, including mixtures of carbon dioxide and methane.
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| 22. |
(WO 2007/134071) STABILIZED FORMULATION OF TRIAMCINOLONE ACETONIDE
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22.11.2007
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A61L 15/16
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PCT/US2007/068496
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THE UNIVERSITY OF MISSISSIPPI
|
| |
A stabilized formulation of triamcinolone acetonide in a bioadhesive base material is provided. The present invention further includes a method of producing a stabilized non-aqueous TAA formulation and methods of measuring the stability of such TAA formulations.
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| 23. |
(WO 2007/134060) CATALYST LAYERS AND RELATED METHODS
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22.11.2007
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B05D 5/12
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PCT/US2007/068482
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UNIVERSITY OF NOTRE DAME DU LAC
|
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Disclosed is a method of preparing a catalyst and a resultant coated substrate. An example method for preparing a catalyst includes dissolving a precursor salt in water to create a dissolved precursor salt. In addition, the method includes adding an ultra-violet sensitizer to the dissolved precursor salt to create a photo emulsion and mixing the photo emulsion with at least one of a surfactant or a stabilizer to create a modified photo emulsion. Further, the modified photo emulsion is applied to a substrate to create a coated substrate, and then the coated substrate is exposed to ultra-violet light. Further, the example method comprises washing the coated substrate after exposing the coated substrate to ultra-violet light and drying the coa...
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| 24. |
(WO 2007/134007) AMINATED MATERIALS FOR ASSAYS
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22.11.2007
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C08G 69/44
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PCT/US2007/068379
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THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
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Protein binding onto a polymeric surface is enhanced by treating the surface with an amine-bearing polymer like poly(ethyiene imine). When used in ELISA, the treated surface improves the performance of the assay.
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| 25. |
(WO 2007/133957) BIOMARKERS FOR MESOTHELIOMA: APOC1 AND APOA2
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22.11.2007
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C12Q 1/00
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PCT/US2007/068161
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VERMILLION, INC.
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The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying mesothelioma status in a patient. In particular, it has been found that ApoC1 and ApoA2 are biomarkers for mesothelioma. The biomarkers can be detected by SELDI mass spectrometry.
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