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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 1. |
(WO 2007/124511) RESORBABLE CERAMICS WITH CONTROLLED STRENGTH LOSS RATES
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01.11.2007
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A61F 2/28
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PCT/US2007/067444
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WASHINGTON STATE UNIVERSITY
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Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion or ion dopants and metal oxide dopants, wherein the composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled strength loss, depending on dopant composition, under body, body fluid or simulated body fluid conditions. Preferably, the at least one dopant is selected from the group consisting of Zn<sp>2+</sp>, Mg<sp>2+</...
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| 2. |
(WO 2007/124494) ENANTIOSELECTVE REACTIONS CATALYZED BY CHIRAL TRIAZOLIUM SALTS
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01.11.2007
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C07D 498/04
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PCT/US2007/067236
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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This invention provides a convenient method for converting imines and other electrophiles into heterocyclic ring systems. The process does not require the use of metallic reagents, and is catalyzed by an organic heterocyclic carbene catalyst. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. Chiral heterocyclic carbene catalysts of the invention and methods of using these catalysts produce chiral heterocycles in high enantiomeric and diastereomeric excess.
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| 3. |
(WO 2007/124481) BIOPRINTING THREE-DIMENSIONAL STRUCTURES ONTO MICROSCALE TISSUE ANALOG DEVICES FOR PHARMACOKINETIC STUDY AND OTHER USES
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01.11.2007
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C12M 1/32
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PCT/US2007/067210
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DREXEL UNIVERSITY
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A microfluidic system for monitoring or detecting a change in a parameter of an input substance, which includes a microfluidic device having a tissue chamber and a tissue analog placed in the tissue chamber, wherein the tissue analog has a vessel structure mimicking naturally occurring vessel network incorporated in the tissue analog.
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| 4. |
(WO 2007/124477) EMBEDDED ARRAYS OF VERTICALLY ALIGNED CARBON NANOTUBE CARPETS AND METHODS FOR MAKING THEM
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01.11.2007
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C01B 31/02
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PCT/US2007/067198
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WILLIAM MARSH RICE UNIVERSITY
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According to some embodiments, the present invention provides a system and method for supporting a carbon nanotube array that involve an entangled carbon nanotube mat integral with the array, where the mat is embedded in an embedding material. The embedding material may be depositable on a carbon nanotube. A depositable material may be metallic or nonmetallic. The embedding material may be an adhesive material. The adhesive material may optionally be mixed with a metal powder. The embedding material may be supported by a substrate or self-supportive. The embedding material may be conductive or nonconductive. The system and method provide superior mechanical and, when applicable, electrical, contact between the carbon nanotubes in the array ...
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| 5. |
(WO 2007/124475) MAGNETIC RESONANCE EYE TRACKING SYSTEMS AND METHODS
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01.11.2007
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A61B 5/055
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PCT/US2007/067192
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EMORY UNIVERSITY
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Embodiments of magnetic resonance eye tracking systems and methods are disclosed. One embodiment, among others, comprises a method that receives magnetic resonance based data and determines direction of a subject's gaze based on the data.
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| 6. |
(WO 2007/124458) METHOD OF THERMAL TREATMENT FOR MYOLYSIS AND DESTRUCTION OF BENIGN UTERINE TUMORS
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01.11.2007
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A61B 8/14
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PCT/US2007/067145
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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A high-power ultrasound heating applicator for minimally-invasive thermal treatment of uterine fibroids or myomas. High-Intensity interstitial ultrasound, applied with minimally-invasive laparoscopic or hysteroscopic procedures, is used to effectively treat fibroids within the myometrium in lieu of major surgery. The applicators are configured with high-power capabilities and thermal penetration to treat large volumes of fibroid tissue (> 70 cm3) in short treatment times (3-20 minutes), while maintaining three-dimensional control of energy delivery to thermally destroy the target volume.
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| 7. |
(WO 2007/124452) METHODS FOR EXPRESSING MULTIPLE SIRNA AND SHRNA FROM A SINGLE VECTOR
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01.11.2007
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A61K 31/70
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PCT/US2007/067138
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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This invention provides methods and vectors for the expression of multiple siRNAs and shRNAs of different target sites or the same site of any gene simultaneously from a single vector, both viral and non-viral. It can function in any cell or organism; down-regulating any mRNAs that share sequence homology of 70% or greater with the expressed siRNAs or shRNAs from the vector. In particular, the methods disclose a special array of promoters within a vector, making expression of multiple siRNAs and shRNAs possible. The invention can be used to knock-down or knock-out the expression of a single gene at the same or multiple sites or different genes of the same or different physiological and pathological pathways for the purpose of gene function ...
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| 8. |
(WO 2007/124450) MOTION ARTIFACT COMPENSATION
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01.11.2007
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G06K 9/40
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PCT/US2007/067136
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
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A technique for correcting translational and rotational motion of an object, such as an object in a magnetic field, utilizes the k-space representation of the object. An initial region in the k-space representation is used as a motion-free reference region, indicative of the motion-free object. Motion-free data adjacent to the initial region are then estimated by extrapolating from the initial region, and the extrapolated data are subsequently used to estimate motion by correlating it with actual data. Segments adjacent to the initial region are then motion corrected and incorporated into an expanding base region. The expanded base region is used in subsequent correction steps. This process is continued until the entire k-space is motion-co...
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| 9. |
(WO 2007/124444) METHOD AND SYSTEM FOR PARALLEL RECONSTRUCTION IN THE K-SPACE DOMAIN FOR APPLICATION IN IMAGING SYSTEMS
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01.11.2007
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G01T 1/24
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PCT/US2007/067125
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UNIVERSITY OF UTAH RESEARCH FOUNDATION
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A method of performing parallel image reconstruction of undersampled image data in k-space. A defined partitioning of a k-space region into a plurality of segments is received. A segment of the plurality of segments is identified wherein data is sampled at less than a Nyquist rate. First imaging data is sampled at the Nyquist rate. A reconstruction coefficient is calculated for at least a portion of the identified segment using the sampled first imaging data. Second imaging data is sampled at less than the Nyquist rate. A value for a missing k-space sample in the identified segment is predicted using the calculated reconstruction coefficient and the sampled second imaging data. An image of the image area is defined using the predicted value...
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| 10. |
(WO 2007/124437) OBJECTIVE-COUPLED SELECTIVE PLANE ILLUMINATION MICROSCOPY
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01.11.2007
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G02B 21/06
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PCT/US2007/067115
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WASHINGTON UNIVERSITY IN ST. LOUIS
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A microscope assembly (102) includes an illumination source (104) coupled to an optical assembly by a coupler (132). The optical assembly includes an objective with optics that move along an optic axis. The illumination source (104) generates a light blade (106) that illuminates a portion of a sample (136) at an illumination plane (110). The light blade (106) induces a fluorescent emission from the sample (136) that is projected through the objective optics to a detector (126). The focal plane (122) of the objective optics is fixed with respect to the illumination source (104) by the coupler (132) so that the illumination plane (110) is coincident with the focal plane (122) as the objective optics move along the optic axis (124). The object...
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| 11. |
(WO 2007/124435) DETECTION OF HISTONE DEACETYLASE INHIBITION
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01.11.2007
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C07C 61/15
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PCT/US2007/067111
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BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
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Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): One example of a method is a method for detecting histone deacetylase activity comprising introducing a compound according to formula (1) to a plurality of cells and monitoring the cells with magnetic resonance spectroscopy.
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| 12. |
(WO 2007/124397) IONIC VISCOELASTICS AND VISCOELASTIC SALTS
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01.11.2007
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C07D 231/00
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PCT/US2007/067047
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TRUSTEES OF BOSTON UNIVERSITY
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One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variet...
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| 13. |
(WO 2007/124383) 1,1'-BINAPHTHYL-BASED INHIBITORS OF NAD+-DEPENDENT DEACETYLASE ACTIVITY AND SIR2-FAMILY MEMBERS
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01.11.2007
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C07C 39/14
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PCT/US2007/067006
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OREGON HEALTH & SCIENCE UNIVERSITY
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Aspects of the present invention provide novel compositions and methods for inhibiting NAD+-dependent deacetylase activity (e.g., SIR2) and for affecting and/or treating SIR2-related biological conditions and disorders including but not limited to cancer, HIV/AIDS, silenced genes, metabolism, apoptosis, aging, and conditions such as Malaria and infectious disease (e.g., <i>Trypanosoma brucei</i> (African sleeping sickness); Leishmaniasis (e.g., <i>Leishmania infantum</i>, etc.); <i>Mycobacterium tuberculosis</i>; and Anthrax). The novel compositions and methods comprising use of novel small molecule inhibitors of NAD+-dependent deacetylase activity (e.g., SIR2 inhibitors) that comp...
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| 14. |
(WO 2007/124357) INTEGRATED MEMS METROLOGY DEVICE USING COMPLEMENTARY MEASURING COMBS
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01.11.2007
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H02N 1/00
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PCT/US2007/066963
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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The present invention provides a device for in-situ monitoring of material, process and dynamic properties of a MEMS device. The monitoring device includes a pair of comb drives, a cantilever suspension comprising a translating shuttle operatively connected with the pair of comb drives, structures for applying an electrical potential to the comb drives to displace the shuttle, structures for measuring an electrical potential from the pair of comb drives; measuring combs configured to measure the displacement of the shuttle, and structures for measuring an electrical capacitance of the measuring combs. Each of the comb drives may have differently sized comb finger gaps and a different number of comb finger gaps. The shuttle may be formed on ...
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| 15. |
(WO 2007/124355) VASCULAR ENDOTHELIAL RECEPTOR SPECIFIC INHIBITORS
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01.11.2007
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A61K 31/33
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PCT/US2007/066960
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NOVA SOUTHEASTERN UNIVERSITY
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The present application describes isoindoles and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful inhibitors of VEGFR.
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| 16. |
(WO 2007/124348) PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION
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01.11.2007
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A61K 51/00
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PCT/US2007/066947
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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Antagonists of group 1 metabotropic glutamate receptors (mGluR) potentiate the effect of positive AMPA receptor modulators on neurotrophin expression, such as brain-derived neurotrophic factor (BDNF). The findings described herein suggest a combinatorial approach for drug therapies, using both positive AMPA receptor modulators and mGluR antagonists, to enhance brain neurotrophism.
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| 17. |
(WO 2007/124331) CARDIOPROTECTIVE AND OTHER USES OF MAMMALIAN TARGET OF RAPAMYCIN (M-TOR) INHIBITORS
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01.11.2007
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A01N 43/00
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PCT/US2007/066910
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VIRGINIA COMMONWEALTH UNIVERSITY
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Novel uses of rapamycin include, e.g., the preconditioning-like effect of rapamycin against infarction in the intact heart as well against necrosis and apoptosis in cardiomyocytes. Other uses, especially in post-heart attack patients and other patients at risk of ischemia/reperfusion injury, are disclosed for rapamycin and other m-TOR inhibitors.
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| 18. |
(WO 2007/124320) CALIBRATION OF FUNCTIONAL MRI OF LIVING TISSUE INVOLVING A BOLD OR BOSS CONTRAST SIMULATION PHANTOM
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01.11.2007
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G01R 33/58
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PCT/US2007/066869
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UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
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Embodiments of the present invention relate to systems and methods for calibrating functional magnetic resonance imaging of living tissue. For example, a calibration method includes providing a contrast signal simulation device configured for generating one or more pre-determined contrast simulation signals selected from a group consisting of BOLD and BOSS contrast simulation signals that simulate at least one contrast signal generated by living tissue of a subject and positioning the contrast signal simulation device adjacent to the subject. The method includes using an imaging instrument to take first and second data sets from the subject's tissue while the contrast signal simulation device is disposed adjacent to the subject and while ge...
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| 19. |
(WO 2007/124314) USE OF ORGANIC CATION TRANSPORTERS FOR CANCER DIAGNOSIS AND THERAPY
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01.11.2007
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C12Q 1/00
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PCT/US2007/066848
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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The present invention provides, for the first time, the finding that organic cation transporters (OCTs) are major determinants of the anticancer activity of platinum-based drugs such as oxaliplatin, and therefore have clinical significance for selecting oxaliplatin as the preferred therapy for a cancer that expresses one or more OCTs, such as colorectal cancer or liver cancer. In addition, the OCT genotype can also be used to predict oxaliplatin response or to select therapy. The present invention also provides methods of treating or inhibiting cancers that expresses one or more OCTs by administering a therapeutically effective amount of a platinum-based drug such as an oxaliplatin analog having an organic non-leaving group with an increase...
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| 20. |
(WO 2007/124313) LIFE INSURANCE WITH A CATASTROPHIC MEDICAL HEALTH BENEFIT
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01.11.2007
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G06Q 40/00
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PCT/US2007/066827
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BOARD OF REGENTS, THE UNIVERSITY OF TEXASSYSTEM
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A life insurance instrument that combines life insurance with a catastrophic medical health benefit is presented. The described life insurance instrument provides a monetary sum to the insured or a beneficiary on the occurrence of death of the insured, and a payment of healthcare expenses to selected healthcare systems for a defined catastrophic illness during a defined time period based on an agreed upon sum for the treatment of defined catastrophic illnesses for the insured in exchange for annual payments during said defined time period. This life insurance instrument 1) benefits an individual by preserving his or her accumulated wealth from the costs of treatment of a catastrophic illness at selected healthcare systems duπng a set time ...
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| 21. |
(WO 2007/124284) BOMBESIN RECEPTOR ANATOGONISTS WITH ANTI-CANCER ACTIVITY
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01.11.2007
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C07K 5/08
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PCT/US2007/066615
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OREGON HEALTH & SCIENCE UNIVERSITY
|
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Synthetic peptides that inhibit ligand-binding by bombesin receptors are provided. Methods for inhibiting growth and inducing apoptosis of neoplastic cells using these peptides are also provided. Methods for treating cancer by administering the peptides are also provided.
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| 22. |
(WO 2007/124216) OPTICAL FIBER FOR DETECTING STRESS AND ASSOCIATED METHOD
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01.11.2007
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G02B 6/00
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PCT/US2007/064066
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UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
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This invention discloses an optical fiber structured to measure stress. The optical fiber includes a core, substantially surrounding the core is a cladding having a plurality of air holes, substantially surrounding the cladding is a buffer, and substantially surrounding the buffer is a jacket.
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| 23. |
(WO 2007/124169) COMPOSITIONS AND METHODS FOR TRANSIENT RECEPTOR POTENTIAL VANILLOID (TRPV) CHANNEL MEDIATED TREATMENTS
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01.11.2007
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A61K 31/165
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PCT/US2007/009908
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THE BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY
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The present inventions relate to therapeutic compositions comprising, and methods utilizing, arachidonic acid derivatives and analogs for treatment of patients demonstrating symptoms of pathological conditions. Specifically, the inventions relate to therapeutic compositions for activating transient receptor potential vanilloid-1 channels (TRPVl). Additionally, therapeutic compositions are provided for increasing TRPVl -type responses. These pathological conditions include, but are limited to, hypertension, in particular salt induced hypertension, and cardiovascular complications, including myocardial infarction, kidney dysfunction, diabetes, and inflammation. Further, the inventions relate to drug screening methods for providing additional ...
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| 24. |
(WO 2007/124151) RAPID 3-DIMENSIONAL BILATERAL BREAST MR IMAGING
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01.11.2007
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A61B 5/055
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PCT/US2007/009824
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THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
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Provided is a method for rapid, 3D, dynamic, projection reconstruction bilateral breast imaging using simultaneous multi-slab volume excitation and radial acquisition of a contrast enhanced bilateral image, in conjunction with SENSE processing, using k-Space Weighted Image Contrast ('KWIC') filtering and multi-coil arrays for signal separation in an interleaved bilateral MR bilateral breast scan that uses conventional Cartesian sampling without parallel imaging. Software was developed for the reconstruction, modeling contrast kinetics using a heuristic model, display by parametric mapping and viewer/analysis of the multidimensional, high frame-rate bilateral breast images.
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| 25. |
(WO 2007/124148) TREATMENT OF CONNECTIVE TISSUE DISORDERS
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01.11.2007
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A61K 48/00
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PCT/US2007/009821
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THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
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The present invention relates to methods of delivering nucleic acids to connective tissue cells and to methods of treating connective tissue disorders; in particular, the invention provides methods of delivering nucleic acids to connective tissue cells and methods of treating connective tissue disorders using parvovirus vectors.
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