|
| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 1. |
(WO 2007/137288) METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF STAPHYLOCOCCUS AUREUS INFECTIONS THROUGH INTERFERENCE WITH OPUC OPERON INTERACTION WITH TRAP
|
29.11.2007
|
A61K 39/40
|
PCT/US2007/069551
|
TUFTS UNIVERSITY
|
| |
The bacterial protein OpuCA, an intracellular part of an ABC transporter, has been shown to interact directly with TRAP. The present invention provides methods and compositions directed at interfering with the interaction between OpuCA and TRAP. The resulting inhibition of TRAP advantageously will reduce pathogenesis of all bacteria that utilize this pathway. The present invention further provides methods and compositions directed at interfering with the interaction between TRAP and the extracellular substrate binding protein OpuCC, or the membrane-associated proteins OpuCB and OpuCD, which, like OpuCA, are encoded by the bacterial OpuC operon. Accordingly, the present methods and compositions will be useful in treating diseases caused by s...
|
| |
|
| 2. |
(WO 2007/137279) HERV-K ANTIGENS, ANTIBODIES, AND METHODS
|
29.11.2007
|
A61K 39/12
|
PCT/US2007/069497
|
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
|
| |
Methods and compositions for cancer diagnostics and therapy are provided. More particular, methods and compositions for detecting, preventing, and treating HERV-K+ cancers are provided. One example of a method may involve a method for preventing or inhibiting cancer cell proliferation by administering to a subject a cancer cell proliferation blocking or reducing amount of a HERV-K env protein binding antibody.
|
| |
|
| 3. |
(WO 2007/137275) STIMULATORS OF OSTEOBLASTOGENESIS AND APPLICATIONS OF THE SAME
|
29.11.2007
|
C07K 16/18
|
PCT/US2007/069493
|
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
|
| |
Compositions that stimulate osteoblastogenesis and the activity of osteoblasts are disclosed. Methods of stimulating osteoblastogenesis and the activity of osteoblasts are disclosed. Methods of treating a mammal for a bone condition by stimulating osteoblastogenesis and the activity of osteoblasts are disclosed. According to the present invention, a composition comprising a TNF blocker is administered to the mammal in an amount effective to stimulate osteoblastogenesis.
|
| |
|
| 4. |
(WO 2007/137271) CATALYSTS FOR HYDROGEN PRODUCTION
|
29.11.2007
|
B01J 23/80
|
PCT/US2007/069488
|
UNIVERSITY OF NOTRE DAME DU LAC
|
| |
Embodiments of the present invention provide catalysts for production of hydrogen from methanol. In an embodiment, a Cu/Zn catalyst may be promoted by Zr and/or Ce, in addition to, in embodiments, Pd or another noble metal. In an embodiment, a chemical composition may have a Cu/Zn base catalyst with a promoter element of Ce, Zr, and/or Pd or another noble metal. Methods of producing hydrogen using such catalysts are also provided.
|
| |
|
| 5. |
(WO 2007/137258) C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE
|
29.11.2007
|
A61K 31/70
|
PCT/US2007/069461
|
NEW YORK UNIVERSITY
|
| |
The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI -type immune response characterized by enhanced IL- 12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.
|
| |
|
| 6. |
(WO 2007/137256) CARBON NANOTUBE BASED IMAGING AGENTS
|
29.11.2007
|
A61K 49/04
|
PCT/US2007/069459
|
WILLIAM MARSH RICE UNIVERSITY
|
| |
Compositions and methods related to carbon nanotubes are provided. More particularly, imaging agents comprising carbon nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.
|
| |
|
| 7. |
(WO 2007/137245) SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION FLUID OUTLET STREAMS
|
29.11.2007
|
A61M 37/00
|
PCT/US2007/069414
|
COLUMBIA UNIVERSITY
|
| |
A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
|
| |
|
| 8. |
(WO 2007/137236) DRUG LOADED CONTRAST AGENTS: COMBINING DIAGNOSIS AND THERAPY
|
29.11.2007
|
A61K 49/00
|
PCT/US2007/069393
|
DREXEL UNIVERSITY
|
| |
This invention provides an improvement to methods of drug loading of ultrasound contrast agents. Echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof produced by the method of the invention wherein the echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof contain at least 10% more of a drug as compared to (1) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug prior to emulsifying or (2) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug to lyophilized polymer microcapsules, nanocapsules, or mixtures thereof.
|
| |
|
| 9. |
(WO 2007/137225) METHOD FOR INDEXING NUCLEIC ACID SEQUENCES FOR COMPUTER BASED SEARCHING
|
29.11.2007
|
G06F 19/00
|
PCT/US2007/069367
|
THE UNIVERSITY OF CHICAGO
|
| |
The present invention relates to a method for indexing nucleic acid sequences to aid computer based searching of nucleic acid sequences by indexing a nucleotide sequence by the presence of unique Kmers in the sequence. The method of the present invention comprises utilizing an algorithm to automatically index a nucleic acid sequence.
|
| |
|
| 10. |
(WO 2007/137210) SYSTEM AND TECHNIQUES FOR MAGNETIC MANIPULATION OF INTERNAL ORGANS DURING MINIMALLY INVASIVE SURGERY
|
29.11.2007
|
A61N 2/10
|
PCT/US2007/069317
|
CREIGHTON UNIVERSITY
|
| |
Systems and techniques for manipulating organs during minimally invasive surgery are disclosed. Magnetic material is delivered to an organ (10) of interest and the organ (10) is manipulated during the procedure via a magnet (30) external to the patient (25). The magnetic material may be delivered in fluidized form by filing a balloon (22).
|
| |
|
| 11. |
(WO 2007/137207) METHOD AND APPARATUS FOR INCREASING BLOOD FLOW IN A BODY PART
|
29.11.2007
|
A61B 17/00
|
PCT/US2007/069314
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
An enclosure is dimensioned to enclose an affected area of a body part plus a small margin around which a releasable seal is attached to make the enclosure substantially airtight around the body part without contacting the area to be treated. A port in the enclosure is attached to tubing for connection of a pump for forcing air under pressure into the enclosure. In the preferred embodiment, the enclosure is an inflatable plastic bag. The compression provided by the air pressure is applied uniformly to the body part to increase blood flow within the body part without physically contacting the affected area of the body part. In one embodiment, the pump is a combination air and vacuum pump so that pressures within the enclosure may be cycled b...
|
| |
|
| 12. |
(WO 2007/137200) PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS
|
29.11.2007
|
A01N 37/00
|
PCT/US2007/069307
|
BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
|
| |
Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.
|
| |
|
| 13. |
(WO 2007/137190) FUNCTIONALLY DIVERSE MACROMOLECULES AND THEIR SYNTHESIS
|
29.11.2007
|
A61K 31/787
|
PCT/US2007/069290
|
THE TEXAS A & M UNIVERSITY SYSTEM
|
| |
Functionally diverse macromolecules and synthetic routes for obtaining the same are disclosed. In certain embodiments, the synthesis proceeds in a divergent manner. In other embodiments, the routes rely on the differential reactivity of monomelic electrophilic triazine building blocks that display protected or unprotected groups. This diversity permits the facile introduction of a variety of diversity groups at multiple positions of these macromolecules, thereby setting the stage for further generational growth of the macromolecule and/or incorporation of other diversity groups such as biocompatible targeting groups.
|
| |
|
| 14. |
(WO 2007/137174) COMPOSITIONS AND METHODS FOR THE DETECTION OF VULNERABLE PLAQUE
|
29.11.2007
|
A61K 51/00
|
PCT/US2007/069267
|
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
|
| |
Targeting polypeptide imaging agents, methods employing the agents, and kits employing the agents are provided. The targeting polypeptide imaging agents may have at least one targeting polypeptide and at least one contrast enhancing imaging agent.
|
| |
|
| 15. |
(WO 2007/137155) CATALYST FREE POLYMERIZATION OF 3,4-ALKYLENEDIOXYPYRROLE AND 3,4-ALKYLENEDIOXYFURAN
|
29.11.2007
|
C08G 61/12
|
PCT/US2007/069228
|
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
|
| |
A method to prepare halogen end-capped polypyrroles, polyfurans or copolymeric pyrroles and furans is presented that readily occurs in a liquid state as well as a solid state without the need of a catalyst from a dihalopyrrole monomer, dihalofuran monomer, or a mixture of monomers. The polymerization mixture can be modified to include a monohalo-monomer for the introduction of a specific end-group or a polyhalo-monomer to form a branched polymer or network. An initiating species can be included in the polymerization mixture to avoid an induction period or to commence the polymerization process on demand. The electroactive polymers can be formed as a bulk material, a coating, or as a film.
|
| |
|
| 16. |
(WO 2007/137144) SINGLE PROTEIN PRODUCTION IN LIVING CELLS FACILITATED BY A MESSENGER RNA INTERFERASE
|
29.11.2007
|
C12P 1/00
|
PCT/US2007/069194
|
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
|
| |
The present invention describes a single-protein production (SPP) system in living E. coli cells that exploits the unique properties of an rnRNA interferase, for example, MazF, a bacterial toxin that is a single stranded RNA- and ACA-specific endoribonuclease, which efficiently and selectively degrades all cellular mRNAs in vivo, resulting in a precipitous drop in total protein synthesis. Concomitant expression of MazF and a target gene engineered to encode an ACA-less mRNA results in sustained and high-level (up to 90%) target expression in the virtual absence of background cellular protein synthesis. Remarkably, target synthesis continues for at least 4 days, indicating that cells retain transcriptional and translational competence despit...
|
| |
|
| 17. |
(WO 2007/137135) ROTENONE ANALOGS: METHOD OF PREPARATION AND USE
|
29.11.2007
|
A01N 25/26
|
PCT/US2007/069178
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
The present invention provides rotenone analogs and methods of making and using them. Labeled with single photon and positron emitting isotopes, the rotenone analogs of the present invention are useful in, for example, clinical imaging applications as tracers to measure cardiac blood flow and detect regions of ischemia.
|
| |
|
| 18. |
(WO 2007/137130) MAGNETORHEOLOGICAL FLUIDS AND THERAPEUTIC USES THEREOF
|
29.11.2007
|
A61K 33/26
|
PCT/US2007/069170
|
BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, on behalf of the University of Nevada
|
| |
In some embodiments, the present disclosure provides methods for stimulating a subject's immune system. Particular methods provide a tumor specific immune response by injecting a tumor with a magnetorheological fluid and applying a magnetic field to the tumor. The immune response can be used to treat disseminated tumors or metastatic cells. Further methods induce a general immune response, such as by treating a section of tissue, such as healthy tissue, with a magnetorheological fluid and applying a magnetic field to the treated tissue. The immune response can be used to treat illness or disease or to enhance the effect of a therapeutic agent. In particular examples, the disclosed methods are used to enhance the effect of immuno stimulants....
|
| |
|
| 19. |
(WO 2007/137127) METHODS FOR CARBONATE PRETREATMENT AND PULPING OF CELLULOSIC MATERIAL
|
29.11.2007
|
D21C 3/02
|
PCT/US2007/069159
|
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
|
| |
A method of pretreating comminuted fibrous material with sodium carbonate and then cooking the pretreated material in the presence of anthraquinone (AQ) is provided. The resulting pulp produced has a higher yield, enhanced strength, and better bleachability compared to pulp produced by prior art methods. AQ may also be introduced to the carbonate pretreatment stage. The method may further include an acid pretreatment providing further enhanced properties to the pulp produced.
|
| |
|
| 20. |
(WO 2007/137124) DEVICES AND METHODS FOR FLUORESCENT INSPECTION AND/OR REMOVAL OF MATERIAL IN A SAMPLE
|
29.11.2007
|
G01N 33/574
|
PCT/US2007/069155
|
UNIVERSITY OF UTAH RESEARCH FOUNDATION
|
| |
An apparatus is provided that includes a light emitting component, a light detecting component, a lock in amplifier, a frequency generator that is operatively linked to the lock in amplifier and the light emitting component, a speaker capable of emitting an audio signal wherein the output audio signal varies depending on the detected fluorescence in the sample, and a visible output of relative fluorescent intensity where the visible output varies depending on the detected fluorescence in the sample. The apparatus may also include a laser that is operatively coupled to the lock in amplifier through a control switch, and focusing lens or an additional type of filter such as an interference filter, a short pass filter, a notch filter, a long p...
|
| |
|
| 21. |
(WO 2007/137123) BIOMECHANICAL TREATMENT FOR OBESITY AND DIABETES
|
29.11.2007
|
A61N 1/00
|
PCT/US2007/069154
|
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
|
| |
Methods of maintaining or improving the metabolic state of a subject, e.g., a human, are disclosed. The methods can include providing to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to maintain or improve the subject's metabolic state. The subject can be diagnosed as having or can be at risk of developing, an obesity-related medical condition, e.g., type 2 diabetes, cardiovascular disease, hypertension, rheumatoid arthritis, and breast cancer. The methods can include a step of identifying a suitable subject by evaluating a physiological parameter that reflects the metabolic state of the subject, e.g., visceral fat content, subcutaneous fat content, body mass index, and blood pre...
|
| |
|
| 22. |
(WO 2007/137112) METHOD AND SYSTEM FOR CORRECTING OPTICAL ABERRATIONS, INCLUDING WIDEFIELD IMAGING APPLICATIONS
|
29.11.2007
|
G02B 21/00
|
PCT/US2007/069135
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
A system and method for correcting optical aberrations in optical devices, such as wide-field microscopes, optical tweezers and optical media devices, such as DVD drives. The system uses adaptive optics to correct optical aberrations, such as spherical and space-variant aberrations. Spherical aberrations can be corrected using one adaptive optical elements and space-variant aberrations can be corrected using numerous adaptive optical elements in tandem. The adaptive optical elements may be of several types, such as a liquid lenses, deformable membrane mirrors or various liquid crystal phase and amplitude modulators. Adaptive optics can also be used to simultaneously shift the focus of the optical device and correct optical aberrations.
|
| |
|
| 23. |
(WO 2007/137000) COMBINATION CANCER CHEMOTHERAPY
|
29.11.2007
|
A61K 31/166
|
PCT/US2007/068601
|
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
|
| |
Provided is a method for improving treatment of a neoplastic condition by combining a therapeutically effective amount of a polyADP-ribose polymerase inhibitor with a therapeutically effective amount of a compound which triggers the release of nucleolin from the G-quadruplexes in rDNA. As specifically exemplified, the compound which increases nucleolin binding is a substituted quinobenzoxazine analog, for example CX-3543.
|
| |
|
| 24. |
(WO 2007/136983) POWER COMBINERS USING META-MATERIAL COMPOSITE RIGHT/LEFT HAND TRANSMISSION LINE AT INFINITE WAVELENGTH FREQUENCY
|
29.11.2007
|
H01P 5/12
|
PCT/US2007/068256
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
Power combining methods and devices for tunnel diode oscillators using the infinite wavelength phenomenon observed in composite right/left-handed (CRLH) meta-material lines are described. One implementation utilizes a series combiner composed of zero degree lines, with each oscillator output port connected directly to the line and combined in-phase, to equally combine the power in phase. In a second implementation, a section of zero degree transmission line implements a stationary wave resonator with oscillators loosely coupled to the resonator, where the wave amplitude and phase are constant along the line. In one test of this second implementation a maximum power combining efficiency of 131 % was obtained with the zeroth order resonator w...
|
| |
|
| 25. |
(WO 2007/136967) RETROSPECTIVE SORTING OF 4D CT INTO BREATHING PHASES BASED ON GEOMETRIC ANALYSIS OF IMAGING FIDUCIALS
|
29.11.2007
|
G06T 5/00
|
PCT/US2007/067847
|
KONINKLIJKE PHILIPS ELECTRONICS, N.V.
|
| |
A respiratory marker (40, 140, 240, 340, 440) includes an elongated detectable portion (42, 342, 442) that is operatively coupled with respiration of an imaging subject such that the elongated detectable portion moves with the respiration. The elongated detectable portion is arranged to intersect images acquired by an imaging scanner (10) at different times and at different positions along a scanner axis (20), and is detectable as a marker feature in the images. A marker position finder (52, 54) is configured to determine positions of the marker features in the images.
|
| |
|
![[Back to Top]](/ipdl/include/backtop.gif){kind=small}
