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| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 26. |
(WO 2007/095233) THIN FILM METAL ALLOY COVERED STENT
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23.08.2007
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A61F 2/06
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PCT/US2007/003792
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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| |
A stent has a structure including a generally rectangular thin film sheet of shape memory alloy wrapped into a generally tubular shape.
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| 27. |
(WO 2007/095230) TREATMENT OF AUTOIMMUNE BLISTERING DISEASE USING ANTI-IgE ANTIBODY
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23.08.2007
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G01N 33/53
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PCT/US2007/003788
|
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
|
| |
This invention relates to the treatment of autoimmune blistering disease. Specifically, the invention relates to the use of anti-IgB antibody, its fragments, derivatives, metabolites or their combination in methods and compositions for the treatment of bullous pemphigoid, pemphigus vulgaris, pemphigus foliaceous, cicatricial pemphigoid, anti-epiligrin pemphigoid, epidermolysis bullosa acquisita, herpes gestationis, dermatitis herpetiformis, bullous lupus, paraneoplastic pemphigous, or a combination or variants thereof.
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| 28. |
(WO 2007/095202) BLOCKADE OF GAMMA-SECRETASE ACTIVITY TO PROMOTE MYELINATION BY OLIGODENDROCYTES
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23.08.2007
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C12N 5/08
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PCT/US2007/003725
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THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
|
| |
Methods are provided for enhancing myelination. Myelination is enhanced by administration of agents that are inhibitors of γ-secretase. Methods of screening for pharmaceutically active compounds that enhance myelination, and for genes involved in myelination are also provided.
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| 29. |
(WO 2007/095201) PSEUDOTYPED RETROVIRAL VECTORS AND METHODS OF USE THEREOF
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23.08.2007
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C12N 15/47
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PCT/US2007/003724
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
The present invention provides nucleic acids encoding recombinant envelope proteins; and packaging cells comprising the nucleic acids, which packaging cells provide for encapsidation of recombinant retroviral vectors. The present invention provides producer cells that produce pseudotyped recombinant retroviral vectors. The present invention further provides methods of purifying pseudotyped recombinant retroviral vectors; and purified pseudotyped recombinant retroviral vectors. The present invention further provides methods of delivering a gene product to an individual. The methods generally involve introducing a subject recombinant retroviral vector into an individual.
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| 30. |
(WO 2007/095187) COMPOSITIONS AND METHODS FOR ANTIBIOTIC POTENTIATION AND DRUG DISCOVERY
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23.08.2007
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A01N 43/16
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PCT/US2007/003698
|
TRUSTEES OF BOSTON UNIVERSITY
|
| |
The present invention provides methods for identifying target genes whose partial or complete functional inactivation potentiates the activity of an antibiotic agent, e.g., a quinolone antibiotic. The invention further provides methods for identifying agents that modulate expression of target genes or that modulate activity of expression products of target genes. Agents identified according to various methods of the invention potentiate the activity of antibiotics such as quinolones, aminoglycosides, peptide antibiotics and β-lactams. Also provided are agents that suppress and/or retard resistance to antibiotics. The inventive methods provide potentiating agents and compositions comprising potentiating agents and antibiotics. Such agents a...
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| 31. |
(WO 2007/095185) VARIANTS IN COMPLEMENT REGULATORY GENES PREDICT AGE-RELATED MACULAR DEGENERATION
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23.08.2007
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C12Q 1/68
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PCT/US2007/003696
|
UNIVERSITY OF IOWA RESEARCH FOUNDATION
|
| |
Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided.
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| 32. |
(WO 2007/095177) SYSTEM AND METHOD FOR SELECTING DIFFERENTIALLY DEPENDENT GENES FROM GENE EXPRESSION DATA
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23.08.2007
|
G06F 19/00
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PCT/US2007/003681
|
UNIVERSITY OF ROCHESTER
|
| |
Dependence between expression levels of different genes is identified through a multivariate method of statistical analysis of single color microarray gene expression data. An algorithm is applied to gene data to identify those genes that are likely to change their relationship with all other genes, and select such genes for further investigation. If genes change their relationship to other genes from phenotype to phenotype, they are treated as likely to change their relationship with one another.
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| 33. |
(WO 2007/095161) METHODS AND COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH INCREASED BONE TURNOVER AND OSTEOPENIA
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23.08.2007
|
C07D 487/04
|
PCT/US2007/003656
|
NEW YORK UNIVERSITY
|
| |
The invention provides methods and compositions for modulating osteoclastogenesis and for treating bone diseases characterized by bone loss or a decrease in bone mass or density, by administering a compound or agent that modulates the adenosine Al receptor, in particular, an inhibitor or antagonist of the Al receptor.
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| 34. |
(WO 2007/095152) TRANSDUCIBLE DELIVERY OF SIRNA BY DSRNA BINDING DOMAIN FUSIONS TO PTD/CPPS
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23.08.2007
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C07K 16/00
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PCT/US2007/003641
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
The disclosure provides fusion polypeptides and constructs useful in delivering anionically charged nucleic acid molecules including diagnostics and therapeutics to a cell or subject. The fusion constructs include a protein transduction domain and a nucleic acid binding domain, or a protein transduction domain and a nucleic acid that is coated with one or more nucleic acid binding domains sufficient to neutralize an anionic charge on the nucleic acid. Also provided are methods of treating disease and disorders such as cell proliferative disorders.
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| |
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| 35. |
(WO 2007/095151) NERVE REGENERATION EMPLOYING KERATIN BIOMATERIALS
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23.08.2007
|
A61K 38/00
|
PCT/US2007/003639
|
WAKE FOREST UNIVERSITY HEALTH SCIENCES
|
| |
A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
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| 36. |
(WO 2007/095137) METHOD FOR CONDUCTIVITY CONTROL OF (AL,IN,GA,B)N
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23.08.2007
|
H01L 21/00
|
PCT/US2007/003607
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
A method of controlled p-type conductivity in (Al, In, Ga, B)N semiconductor crystals. Examples include { 1011 } GaN films deposited on {100} MgAl2O4 spinel substrate miscut in the <011> direction. Mg atoms may be intentionally incorporated in the growing semipolar nitride thin film to introduce available electronic states in the band structure of the semiconductor crystal, resulting in p-type conductivity. Other impurity atoms, such as Zn or C, which result in a similar introduction of suitable electronic states, may also be used.
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| 37. |
(WO 2007/095126) ASSAYS TO PREDICT ATHEROSCLEROSIS AND DYSFUNCTIONAL HIGH-DENSITY LIPOPROTEIN
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23.08.2007
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G01N 33/53
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PCT/US2007/003588
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
This invention provides novel assays for the detection of dysfunctional HDL. The assays are good diagnostics and/or prognostics for atherosclerosis or other pathologies characterized by an inflammatory response. In certain embodiments the methods involve measurements of heme-related HDL-associated proteins (e.g., haptoglobin, hemopexin, etc.), and/or measurements of the relative distribution of HDL-associated proteins between HDL and the non-lipoprotein fractions of plasma/serum, and/or measurements of the ability of pro-inflammatory HDL to consume nitric oxide, and/or measurement of the ability of HDL to inhibit LDL aggregation.
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| 38. |
(WO 2007/095069) NF-YA ACTIVATES MULTIPLE HEMATOPOIETIC STEM CELL (HSC) REGULATORY GENES AND PROMOTES HSC SELF-RENEWAL
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23.08.2007
|
C12N 15/85
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PCT/US2007/003434
|
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
|
| |
Provide are methods for enhancing hematopoietic stem cell (HSC) self-renewal and/or proliferation resulting from increasing the intracellular concentration of NF-Ya in the cell, as well as, the resulting enhanced HSC resulting from the use of the provided methods, therapeutic use of such enhanced HSC and kits relating thereto.
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| |
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| 39. |
(WO 2007/095007) SYSTEMATIC GENOMIC LIBRARY AND USES THEREOF
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23.08.2007
|
C12N 15/87
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PCT/US2007/003147
|
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
|
| |
The present invention provides genomic DNA libraries that are systematically arranged on plasmids, methods of making and using the libraries, and plasmids that make up the libraries.
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| 40. |
(WO 2007/094986) METHODS OF EXPRESSING GAM-NEGATIVE GLYCOSAMINOGLYCOSAMINOGLYCAN SYNTHASE GENES IN GRAM-POSITIVE HOSTS
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23.08.2007
|
A61K 31/715
|
PCT/US2007/003016
|
THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
|
| |
The present invention relates to a Gram-negative glycosaminoglycan gene and methods of making and using same. The present invention relates to recombinant Gram- positive host cells containing a Gram-negative glycosaminoglycan synthase gene, and methods of producing glycosaminoglycans using such recombinant host cells.
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| |
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| 41. |
(WO 2007/094929) CELL CULTURE WELL-PLATES HAVING INVERTED COLLOIDAL CRYSTAL SCAFFOLDS
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23.08.2007
|
C12M 3/00
|
PCT/US2007/001751
|
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
|
| |
A three dimensional inverted colloidal crystal scaffold is described which comprises a substrate having at least one well. The scaffold also includes a three dimensional matrix comprising a transparent biocompatible polymeric network containing microspherical voids. The microspherical voids are each connected to at least one other void through inter-connecting pores. Additionally, an apparatus for producing such a colloidal crystal scaffold is described. Methods for making the inverted colloidal crystal scaffold, for using the scaffold and for identifying the effects of a drug, pharmaceutical or toxin on a living cell using the inverted colloidal crystal scaffold are also disclosed.
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| 42. |
(WO 2007/094924) HUMAN TELOMERASE REVERSE TRANSCRIPTASE PEPTIDES
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23.08.2007
|
A61K 39/00
|
PCT/US2007/001587
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
Tumor antigens can be categorized as tumor type specific or common. Telomerase reverse transcriptase (TRT) is the first bona fide common tumor antigen. While several 9mer peptides of the human TRT (hTRT) have been identified for HLA-A2, the most prevalent (~50%) HLA type in humans, little information exists on peptides for the remaining HLA types. As described herein, a multi-step approach was taken to select and characterize a panel of HLA-B7 9mer peptides as candidate immunogens. Specifically, several of algorithm based predictions, in vivo immunization of HLA-B7 transgenic mice, in vitro immunization of human blood lymphocytes, in vivo processing and supertype binding were employed to identify HLA-B7-restricted epitopes in hTRT. A correl...
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| 43. |
(WO 2007/094912) BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
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23.08.2007
|
C07D 513/04
|
PCT/US2007/001215
|
UNIVERSITY OF KENTUCKY
|
| |
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
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| |
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| 44. |
(WO 2007/094885) IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE
|
23.08.2007
|
C12N 9/78
|
PCT/US2006/061750
|
SOUTHERN METHODIST UNIVERSITY
|
| |
The present disclosure relates to methods of rational genome mining. A method may include narrowing the number of clones that would otherwise need to be screened and/or identifying a gene with a desired catalytic activity. The disclosure also relates to a nitrile hydrolase from Bradyrhizobium japonicum USDA110 first identified by rational genome mining. In addition, the disclosure relates to nitrilase bll6402 and catalytically active variants capable of converting an α-hydroxy nitriles, a β-hydroxy nitrile and/or an α, ω-dinitrile to a carboxylic acid.
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| 45. |
(WO 2007/094870) TOXICOLOGY AND CELLULAR EFFECT OF MANUFACTURED NANOMATERIALS
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23.08.2007
|
G01N 33/567
|
PCT/US2006/060369
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. We have performed whole genome expression array analysis and high content image analysis-based phenotypic measurements on human skin fibroblast cell populations exposed to multiwall carbon nano-onions (MWCNOs), multiwall carbon nanotubes (MWCNTs), and semiconductor nanocrystals. Here we demonstrate that exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular tr...
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| 46. |
(WO 2007/094856) METHOD AND APPARATUS FOR IDENTIFYING AN IMAGING DEVICE
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23.08.2007
|
H04N 5/225
|
PCT/US2006/047846
|
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
|
| |
Techniques for identifying whether an image is derived from a camera or imaging device, and/or from which camera, or imaging device, an image derives are provided. The imaging device's reference noise pattern, a unique stochastic characteristic of all common digital imaging sensors, including CCD, CMOS (Foveon™ X3), and JFET is analyzed. The measured or inferred noise pattern of two images may be extracted and then cross correlated, with a high correlation being consistent with a common imager. Various preprocessing techniques may be used to improve tolerance to various types of image transform. It is also possible to perform the analysis without explicit separation of inferred image and inferred noise.
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| 47. |
(WO 2007/094854) RNA VIRUS VACCINES AND METHODS
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23.08.2007
|
A61K 39/12
|
PCT/US2006/047696
|
THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
|
| |
The invention is a vaccine, and method of vaccination, against RNA viruses, including RNA viruses in the family Flaviviridae, which includes for example West Nile Virus, Yellow fever virus, Dengue fever virus, Hepatitis C virus, Pestiviruses, Bovine viral diarrhea virus, and Classical Swine fever virus, wherein the vaccine comprises the RNA virus or immunogenic portions thereof, which have been treated with and rendered non-pathogenic by a phenothiazine dye and visible light, the phenothiazine dyes, including, but not limited to, Methylene Blue (MB), Methylene Green, 1 -methyl MB, 1,9-dimethyl MB, Azure A, Azure B, Azure C, thionine, and toluidine blue, or by squalene. The invention includes novel strains of WNV for use in producing a vacci...
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| 48. |
(WO 2007/094832) RECURSIVE AND TRELLIS-BASED FEEDBACK REDUCTION FOR MIMO-OFDM WITH RATE-LIMITED FEEDBACK
|
23.08.2007
|
H04L 27/00
|
PCT/US2006/044373
|
THE UNIVERSITY OF CONNECTICUT
|
| |
Techniques are provided for reducing feedback while maintaining performance in a MIMO-OFDM system. The disclosed techniques employ finite- rate feedback methods that uses vector quantization compression. The disclosed methods/techniques generally involve: receiving a plurality of symbols from a plurality of sub-carriers at a receiver; selecting a plurality of indices of codewords corresponding to a codebook of pre-coding weighting matrices for the sub-carriers based on vector quantization compression of the codewords; and transmitting the selected indices over a wireless channel to a transmitter. Finite state vector quantization feedback makes use of a finite state vector quantizer (FSVQ), which is a recursive vector quantizer (VQ) with a f...
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| 49. |
(WO 2007/094829) ISOLATED AND FIXED MICRO AND NANO STRUCTURES AND METHODS THEREOF
|
23.08.2007
|
A61F 2/00
|
PCT/US2006/043305
|
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
|
| |
Discrete micro and nanoscale particles are formed in predetermined shapes and sizes and predetermined size dispersions. The particles can also be attached to a film to form arrays of particles on a film. The particles are formed from molding techniques that can include high throughput and continuous particle molding.
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| 50. |
(WO 2007/094817) BIOSENSORS INCLUDING METALLIC NANOCAVITIES
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23.08.2007
|
G01N 33/53
|
PCT/US2006/030003
|
UNIVERSITY OF UTAH RESEARCH FOUNDATION
|
| |
A biomolecular assay includes a substrate with a metallic layer on at least one surface thereof. The metallic film includes nanocavities. The nanocavities are configured to enhance signals that are representative of the presence or amount of one or more analytes in a sample or sample solution, and may be configured to enhance the signal by a factor of about two or more or by a factor of about three or more. Such signal enhancement may be achieved with nanocavities that are organized in an array, randomly positioned nanocavities, or nanocavities that are surrounded by increased surface area features, such as corrugation or patterning, or nanocavities that have quadrilateral or triangular shapes with tailored edge lengths, or with a plurality...
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