|
| Title |
Pub. Date |
Int. Class |
App. Num |
Applicant |
| 26. |
(WO 2007/103739) METHODS AND COMPOSITIONS RELATED TO CYCLIC PEPTIDE SYNTHESIS
|
13.09.2007
|
A61K 38/12
|
PCT/US2007/063089
|
THE UNIVERSITY OF UTAH RESEARCH FOUNDATION
|
| |
Disclosed are compositions and methods for cyclization of polymers such as peptides.
|
| |
|
| 27. |
(WO 2007/103726) ARTERY IMAGING SYSTEM
|
13.09.2007
|
G06K 9/00
|
PCT/US2007/063069
|
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
|
| |
Techniques for imaging a blood vessel are described. A transducer attached to a catheter is guided to a first site within a blood vessel. The catheter is moved to a second site proximal to the first site at a speed selected to enable the transducer to generate a signal indicative of a geometry of the wall, the lumen, and a portion of the side branch. A first image of the blood vessel obtained from the signal is oriented with a second image of the blood vessel such that a first portion of the first image aligns with a second portion of the second image.
|
| |
|
| 28. |
(WO 2007/103706) NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION
|
13.09.2007
|
A61B 5/055
|
PCT/US2007/063034
|
THE OHIO STATE UNIVERSITY
|
| |
A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyaniiie derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
|
| |
|
| 29. |
(WO 2007/103665) POLYFUNCTIONAL COMPOUNDS AND USES AS IMPLANT MATERIALS
|
13.09.2007
|
C07C 69/34
|
PCT/US2007/062882
|
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
|
| |
The synthesis and characterization of polymer core initiators are described herein. Polymer core initiators are used to prepare the polyfunctional prepolymers described herein, which may be optionally tethered. The polyfunctional prepolymers described herein are used to prepare cements, optionally with added co-monomers, for repairing and restoring tissues.
|
| |
|
| 30. |
(WO 2007/103579) POWER GENERATING LEG
|
13.09.2007
|
A61F 5/00
|
PCT/US2007/006122
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
A power generating leg, configurable to be coupled to a person's lower limb, comprising a thigh link, a shank link, a knee mechanism, a torque generator, and a power unit The knee mechanism is connected to said thigh link and said shank link, and allows movements of said thigh link and said shank link relative to each other The torque generator is configured to generate torque between said shank link and said thigh link The power unit is coupled to said torque generator, and configured to cause said torque generator to generate torque In a power regeneration mode, said power unit causes said torque generator to generate a torque that opposes the angular velocity of said thigh link and said shank link and said power unit converts a portion o...
|
| |
|
| 31. |
(WO 2007/103558) HYBRID ENERGY TRANSFER FOR NUCLEIC ACID DETECTION
|
13.09.2007
|
C12Q 1/68
|
PCT/US2007/006041
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
Assays using enzymatic degradation of RNA/DNA heteroduplexes are provided for the detection of target nucleic acid molecules. Such enzymatic degradation may be obtained by enzymes including RNaseH. Exemplary methods include Probe Trapping (PT), Hybrid Energy Transfer (HET), and Fluorescent Probe Degradation (FPD). The assays make use of an RNA or chimeric RNA/DNA probe which recognizes a target DNA sequence and forms an RNA/DNA heteroduplex that is the substrate for the enzyme RNaseH which degrades the RNA portion of the probe. Degraded probe fragments diffuse away from the DNA target leading to a detectable signal and allowing the DNA target to hybridize to another probe. Probe degradation is cycled over time. The assays disclosed herein a...
|
| |
|
| 32. |
(WO 2007/103541) DIAGNOSTIC AND PROGNOSTIC METHODS FOR LUNG DISORDERS USING GENE EXPRESSION PROFILES FROM NOSE EPITHELIAL CELLS
|
13.09.2007
|
G01N 33/574
|
PCT/US2007/006006
|
THE TRUSTEES OF BOSTON UNIVERSITY
|
| |
The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer.
|
| |
|
| 33. |
(WO 2007/103538) METHODS OF MULTIPLE ANTIBODY LABELING AND USES THEREOF
|
13.09.2007
|
G01N 33/53
|
PCT/US2007/005996
|
UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE
|
| |
The invention relates, in part, to methods of using multiple antibodies raised in two or more different species to label and identify cells, organisms, and additional targets. The invention additionally relates, in part, to diagnostic assays for disorders such as cancer, identification of organisms or contaminants in samples, and to assays to assess cell status, such as cell differentiation and cell lineage.
|
| |
|
| 34. |
(WO 2007/103536) PHOTOINDUCED PHASE SEPARATION OF GOLD IN TWO-COMPONENT NANOPARTICLES TO FORM NANOPRISMS
|
13.09.2007
|
B22F 1/00
|
PCT/US2007/005988
|
NORTHWESTERN UNIVERSITY
|
| |
Nanoprisms containing silver and gold are disclosed. The nanoprisms exhibit the properties of pure silver nanoprisms, but are less susceptible to silver modification or reaction by a surrounding environment than pure silver nanoprisms due to the presence of the gold. The gold surface of the nanoprisms can be further modified, using known gold-modification techniques.
|
| |
|
| 35. |
(WO 2007/103523) ANTIOXIDANT PROTEIN, COMPOSITIONS, AND METHODS OF USE
|
13.09.2007
|
C12N 9/00
|
PCT/US2007/005968
|
YALE UNIVERSITY
|
| |
The present invention provides a novel antioxidant protein (SAOP) comprising a MOCO Sulfurase C-terminal Domain (MOSC), which may be secreted and which has antioxidant activity, as demonstrated by its ability to protect cultured cells from oxidative stress, and by its ability to increase GSH concentration. The present invention also provides polynucleotides encoding the antioxidant protein, as well as vectors containing the polynucleotide under control of regulatory sequences, and corresponding host cells. The present invention also provides a composition comprising an effective amount of the antioxidant protein with a pharmaceutically acceptable carrier or excipient. The composition finds use in ameliorating oxidative stress in a mammal, a...
|
| |
|
| 36. |
(WO 2007/103522) SOLUBLE MONOMERIC EPHRIN A1
|
13.09.2007
|
C12N 5/06
|
PCT/US2007/005964
|
WAKE FOREST UNIVERSITY HEALTH SCIENCES
|
| |
The present disclosure provides a compound ephrinA1 in monomeric form, and methods of use of ephrinA1. Included are methods of detecting a cancer tumor expressing the oncogenic receptor EphA2 in a subject, a method of treating a cancer expressing the oncogenic receptor EphA2 in a subject, and a method of treating a cancer in a subject by administering a first compound that specifically binds to Eph receptors, while concurrently administering a second compound that specifically binds to IL13 receptors.
|
| |
|
| 37. |
(WO 2007/103508) LIGANDS FOR NEMATODE NUCLEAR RECEPTORS AND USES THEREOF
|
13.09.2007
|
G01N 33/573
|
PCT/US2007/005944
|
BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
|
| |
Anti-nematode compounds, compositions, and methods for identifying such compound are disclosed, where the compounds have the formula I: where Q, Q', R<sp>1</sp>, R<sp>2</sp>, and n are defined herein
|
| |
|
| 38. |
(WO 2007/103474) DRUG ADHERENCE MONITORING SYSTEM
|
13.09.2007
|
A61M 11/00
|
PCT/US2007/005890
|
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
|
| |
The present invention provides novel methods for monitoring subject adherence in taking prescribed drugs by detecting markers in exhaled breath after a subject takes the prescribed drug. In particular, the present invention provides novel methods for making additives that are combined with the drug(s). Upon biological breakdown of the drug/additive formulation in a subject's body, markers resulting directly from the biological breakdown of the additives are detected in exhaled breath using sensor technology. In certain embodiments of the invention, the drug adherence monitoring systems and methods include a reporting system capable of tracking subject compliance (either remotely or proximately) and of providing necessary alerts to the subje...
|
| |
|
| 39. |
(WO 2007/103440) CATALYTIC PROCESS FOR DEEP OXIDATIVE DESULFURIZATION OF LIQUID TRANSPORTATION FUELS
|
13.09.2007
|
C01G 31/00
|
PCT/US2007/005838
|
SAUDI ARABIAN OIL COMPANY
|
| |
Sulfur-containing compounds, including specifically thiophenic compounds, in a liquid hydrocarbon feedstream are catalytically oxidized by combining the hydrocarbon feedstream with a catalytic reaction mixture that includes a peroxide that is soluble in water or in a polar organic acid, at least one carboxylic acid, and a catalyst that is a transition metal salt selected from the group consisting of (NH4)2WO4, (NH4)6 W12O40. H2O, Na2WO4, Li2WO4, K2WO4, MgWO4, (NH4)2MoO4, (NH4)6 Mo7O24. 4H2O, MnO0 and NaVO3; the mixture is vigorously agitated for a time that is sufficient to oxidize the sulfur-containing compounds to form sulfoxides and sulfones; the reaction mixture is allowed to stand and separate into a lower aqueous layer containing the ...
|
| |
|
| 40. |
(WO 2007/103435) BIOAVAILABLE CURCUMINOID FORMULATIONS FOR TREATING ALZHEIMER'S DISEASE AND OTHER AGE-RELATED DISORDERS
|
13.09.2007
|
A01N 65/00
|
PCT/US2007/005829
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
Curcuminoid formulations having enhanced bioavailability are provided and comprise a curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically acceptable inhibitor. A method of treating Alzheimer's and other age-related diseases by administering such a composition is also provided.
|
| |
|
| 41. |
(WO 2007/103422) MESOPOROUS CARBON FIBER WITH A HOLLOW INTERIOR OR A CONVOLUTED SURFACE
|
13.09.2007
|
D01F 9/12
|
PCT/US2007/005809
|
CLEMSON UNIVERSITY
|
| |
Convoluted activated carbon fibers and methods for their preparation are described. The activated carbon materials are engineered to increase the proportion of activated porous material proximate to external surfaces and decrease the proportion of activated porous material internal and distance from these surfaces. The convoluted activated carbon fibers may be used in all manner of devices that contain high surface area carbon materials, including but not limited to various electrochemical devices (e.g., capacitors, batteries, fuel cells, and the like), hydrogen storage devices, filtration devices, catalytic substrates, and the like.
|
| |
|
| 42. |
(WO 2007/103419) STRUCTURES AND DESIGNS FOR IMPROVED EFFICIENCY AND REDUCED STRAIN III-NITRIDE HETEROSTRUCTURE SEMICONDUCTOR DEVICES
|
13.09.2007
|
H01L 29/732
|
PCT/US2007/005806
|
THE ARIZONA BOARD OF REGENTS, A BODY CORPORATE ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY
|
| |
The present invention provides semiconductor structures, and methods for making semiconductor structures, comprising an InA1N and/or InA1GaN strain relief layer that have a lattice constant larger than that of a substrate film upon which it is grown such that it allows the growth of strain-free or low-strain semiconductor devices.
|
| |
|
| 43. |
(WO 2007/103397) PATTERN MATCHING TECHNIQUE FOR HIGH THROUGHPUT NETWORK PROCESSING
|
13.09.2007
|
G06F 17/30
|
PCT/US2007/005733
|
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
|
| |
A pattern matching technique for high throughput network processing includes a simple yet powerful special purpose architecture and a set of novel string matching algorithms that can work in unison. The novel set of algorithms allow for bit-level partitioning of rules such that may be more easily implemented in hardware or software. The result is a device that maintains tight worst case bounds on performance, can be updated with new rules without interrupting operation, compiles in seconds instead of hours, and is ten times more efficient than the existing best known solutions in this area.
|
| |
|
| 44. |
(WO 2007/103375) GATING GRID AND METHOD OF MANUFACTURE
|
13.09.2007
|
H01R 43/00
|
PCT/US2007/005697
|
STILLWATER SCIENTIFIC INSTRUMENTS
|
| |
An electrochemically activated fluid (20, 22, 44, 45, 51, 52, 190, 192) is provided, which has an anolyte and a catholyte. For example, a sparged anolyte and a sparged catholyte (51, 52) are provided. In another example, a combined anolyte and catholyte (71, 160) is provided.
|
| |
|
| 45. |
(WO 2007/103368) METHODS FOR REGULATING INFLAMMATORY MEDIATORS AND PEPTIDES USEFUL THEREIN
|
13.09.2007
|
A61K 38/00
|
PCT/US2007/005688
|
BIOMARCK PHARMACEUTICALS, LTD.
|
| |
The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from the vesicles or granules in the inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. MANS peptide and active fragments thereof are useful in such methods.
|
| |
|
| 46. |
(WO 2007/103365) RANDOM RNAI LIBRARIES, METHODS OF GENERATING SAME, AND SCREENING METHODS UTILIZING SAME
|
13.09.2007
|
C12Q 1/68
|
PCT/US2007/005682
|
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
|
| |
This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.
|
| |
|
| 47. |
(WO 2007/103353) METHODS, SYSTEMS, AND MEDIA FOR FORMING LINEAR COMBINATIONS OF DATA
|
13.09.2007
|
G01N 31/00
|
PCT/US2007/005655
|
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
|
| |
Methods, systems, and media for forming linear combinations of data are provided. In some embodiments, methods for forming a linear combination of data include: receiving at a device a first codeword, wherein the first codeword comprises a linear combination of at least a first data unit including data, and a second data unit including data; encoding at the device the first codeword and a third data unit including data to form a second codeword, wherein the second codeword includes a linear combination of at least the first data unit, the second data unit, and the third data unit; and transmitting from the device the second codeword.
|
| |
|
| 48. |
(WO 2007/103349) DEVICES, METHODS AND COMPOSITIONS FOR PRESBYOPIA CORRECTION USING ULTRASHORT PULSE LASERS
|
13.09.2007
|
A61N 5/06
|
PCT/US2007/005648
|
THE TRUSTEES OF PRINCETON UNIVERSITY
|
| |
The invention relates to devices, compositions and methods used to improve vision and/or to treat an eye lens disease or condition. In some embodiments, the invention relates to altering or removing eye lens material for the treatment of presbyopia. In additional embodiments, the invention relates to placing compositions in a lens of an eye to improve elasticity of the lens both therapeutically by improving elasticity and/or improving refractive properties and/or prophylactically by preventing renewed stiffening and/or renewed deterioration of the lens refractive properties. In further embodiments, the invention relates to devices and methods of obtaining and analyzing data for use in altering the lens to optimize its elasticity and/or refr...
|
| |
|
| 49. |
(WO 2007/103346) POLYESTER BASED DEGRADABLE COMPOSITION AND IMPLANTABLE BIOMEDICAL ARTICLES
|
13.09.2007
|
C08G 18/34
|
PCT/US2007/005643
|
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
|
| |
A method of making an aliphatic polyester prepolymer, comprising: reacting, alone or in combination with other reactants, a diol with at least a first diacid (or a diester of said first diacid) to produce an aliphatic polyester prepolymer. The first diacid is preferably a trans-beta-hydromuconic acid (HMA). In some embodiments, the diol contains at least one ether linkage. In some embodiments the diol is further reacted with at a second diacid, or a diester of said second diacid, wherein said second diacid is different from said first diacid. Prepolymers produced from such processes and articles formed therefrom are also described.
|
| |
|
| 50. |
(WO 2007/103273) THIOREDOXIN AND THIOREDOXIN REDUCTASE INHIBITORS
|
13.09.2007
|
A01N 41/10
|
PCT/US2007/005530
|
TRUSTEES OF BOSTON UNIVERSITY
|
| |
The present invention relates to sulfone derivatives and to their use as modulators of the thioredoxin/thioredoxin reductase redox system, including for the treatment and/or prevention of pathophysiological conditions mediated by thioredoxin/thioredoxin reductase, such as cancer, HIV/ AIDS, Alzheimer's disease, rheumatoid arthritis, and skin disorders. Also provided are pharmaceutical compositions comprising the inventive sulfones.
|
| |
|
![[Back to Top]](/ipdl/include/backtop.gif){kind=small}
