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Search result: 52 of 140 |
(WO/2008/054659) AN IMPROVED METHOD OF MICRO-ENCAPSULATION
- Biblio. Data
- Description
- Claims
- National Phase
- Notices
- Documents
| Latest bibliographic data on file with the International Bureau
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| IPC: | A61K 9/14 (2006.01), A61K 9/50 (2006.01) | |||||||||||
| Applicants: | XAVIER UNIVERSITY OF LOUISIANA [US/US]; 1 Drexel Dr., New Orlean, LA 70125 (US) (All Except US). MANDAL, Tarun, K. [US/US]; (US) (US Only). GRAVES, Richard [US/US]; (US) (US Only). | |||||||||||
| Inventors: | MANDAL, Tarun, K.; (US). GRAVES, Richard; (US). | |||||||||||
| Agent: | KIESEL, William, David et al.; 2355 Drusilla Lane, Baton Rough, LA 70809 (US). | |||||||||||
| Priority Data: |
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| Title: | AN IMPROVED METHOD OF MICRO-ENCAPSULATION | |||||||||||
| Abstract: | A method of preparing micro-capsules. The active ingredient, preferably provided in the form of an acid salt dissolved in a basic aqueous solution, is emulsified into a polymer solution, preferably PLGA in a relatively volatile solvent such as dichloromethane, to create a water in oil emulsion. This emulsion is further emulsified into an aqueous solution having a pH of a between about 7.4 and 8.0 and most preferably between about 7.8 and 8.0 to create a water in oil in water solution. The polymer solvent is allowed to evaporate, causing the emulsified active ingredient and surrounding polymer matrix to precipitate, thereby forming the micro-capsules. The micro-capsules are separated from the suspension, washed and freeze dried. The method has a very high encapsulation efficiency, even at high loading rates. Additionally, the dissolution rate of the micro-particles produced by the method is very steady over a long period of time. | |||||||||||
| Designated States: |
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. African Regional Intellectual Property Org. (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW) Eurasian Patent Organization (EAPO) (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM) European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR) African Intellectual Property Organization (OAPI) (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). | |||||||||||
| Publication Language: | English (EN) |
| Filing Language: | English (EN) |
