IPC 7 English version C07K !A-C07K 9/00

C07K-C07K00900

SECTION C – CHEMISTRY; METALLURGY

C 07

ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B 33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B 3/00, C25B 7/00) [2]

C 07 K

PEPTIDES (peptides in foodstuffs A23, e.g. obtaining protein compositions for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing ß-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D 519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific, but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G 69/00; macromolecular products derived from proteins C08H 1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N 15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N 33/00) [4]

Notes

(1)

In this subclass, the following terms or expressions are used with the meanings indicated:

–

"amino acids" are compounds in which at least one amino group and at least one carboxyl group are bound to the same carbon skeleton and the nitrogen atom of the amino group may form part of a ring;

–

"normal peptide link" is one between an alpha-amino group of an amino acid and the carboxyl group – in position 1 – of another alpha-amino acid;

–

"abnormal peptide link" is a link where at least one of the linked amino acids is not an alpha-amino acid or a link formed by at least one carboxyl or amino group being part of the side chain of an alpha-amino acid;

–

"peptides" are compounds containing at least two amino acid units, which are bound through at least one normal peptide link, including oligopeptides, polypeptides and proteins, where

(i)

"linear peptides" may comprise rings formed through S–S bridges, or through an hydroxy or a mercapto group of an hydroxy- or a mercapto-amino acid and the carboxyl group of another amino acid (e.g. peptide lactones) but do not comprise rings which are formed only through peptide links;

(ii)

"cyclic peptides" are peptides comprising at least one ring formed only through peptide links; the cyclisation may occur only through normal peptide links or through abnormal peptide links, e.g. through the 4-amino group of 2,4-diamino-butanoic acid. Thus, cyclic compounds in which at least one link in the ring is a non-peptide link are considered as "linear peptides";

(iii)

"depsipeptides" are compounds containing a sequence of at least two alpha-amino acids and at least one alpha-hydroxy carboxylic acid, which are bound through at least one normal peptide link and ester links, derived from the hydroxy carboxylic acids, where

(a)

"linear depsipeptides" may comprise rings formed through S–S bridges, or through an hydroxy or a mercapto group of an hydroxy-, or mercapto-amino acid and the carboxyl group of another amino- or hydroxy-acid but do not comprise rings formed only through peptide or ester links derived from hydroxy carboxylic acids, e.g. Gly-Ala-Gly-OCH₂CO₂H and Gly-OCH₂CO-Ala-Gly are considered as "linear depsipeptides", but HOCH₂CO-Gly-Ala-Gly does not contain an ester link, and is thus a derivative of Gly-Ala-Gly which is covered by C07K 5/08;

(b)

"cyclic depsipeptides" are peptides containing at least one ring formed only through peptide or ester links – derived from hydroxy carboxylic acids –, e.g. Gly-Ala-Gly-OCH₂CO; [4]

(iv)

"hybrid peptides" are peptides produced through fusion or covalent binding of two or more heterologous peptides.

(2)

Therapeutic activity of compounds is further classified in subclass A61P. [7]

(3)

Fragments of peptides or peptides modified by removal or addition of amino acids, by substitution of amino acids by others, or by combination of these modifications are classified as the parent peptides. However, fragments of peptides having only four or less amino acids are also classified in group C07K 5/00. [6]

(4)

Peptides prepared by chemical processes and having an amino acid sequence derived from naturally occurring peptides are classified with the natural one. [6]

(5)

Peptides prepared by recombinant DNA technology are not classified according to the host, but according to the original peptide expressed, e.g. HIV peptide expressed in E. coli is classified with HIV peptides. [6]

(6)

In this subclass, it is desirable to add the indexing codes of groups C07K 101:00 to C07K 123:00. The indexing codes should be unlinked. [6]

(7)

In this subclass, it is desirable to add the indexing codes of subclass C07M. The indexing codes should be unlinked. [6]

Subclass Index

PEPTIDES

Preparation

C07K 1/00

of undefined number of amino acids

C07K 2/00

Having up to 20 amino acids in an undefined or only partially defined sequence

C07K 4/00

Having up to 20 amino acids in a fully defined sequence

C07K 5/00 to C07K 9/00

Depsipeptides having up to 20 amino acids in a fully defined sequence

C07K 11/00

Having more than 20 amino acids

C07K 14/00

Immunoglobulins

C07K 16/00

Carrier-bound or immobilised peptides

C07K 17/00

Hybrid peptides

C07K 19/00

General processes for the preparation of peptides [4]

in solution [4]

on carriers [4]

using protecting groups or activating agents [4]

using activating agents [4]

using coupling agents [4]

107

by chemical modification of precursor peptides [6]

113

without change of the primary structure [6]

by hydrolysis [4]

Labelling of peptides [6]

Extraction; Separation; Purification [4,6]

by chromatography [6]

Ion-exchange chromatography [6]

Partition-, reverse-phase or hydrophobic interaction chromatography [6]

Affinity chromatography or related techniques based upon selective absorption processes [6]

by electrochemical means [6]

Electrophoresis [6]

Isoelectric focusing [6]

by precipitation [6]

as complexes [6]

by filtration, ultrafiltration or reverse osmosis [6]

by a combination of two or more processes of different types [6]

Peptides of undefined number of amino acids; Derivatives thereof [6]

Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof [6]

from viruses [6]

from bacteria [6]

from fungi [6]

from algae; from lichens [6]

from plants [6]

from animals; from humans [6]

Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof [4]

Note

In this group, the following expression is used with the meaning indicated: [6]

–

"first amino acid" means the first amino acid from the left side, i.e. the N-terminal amino acid, of the peptide sequence. [6]

containing at least one abnormal peptide link [4]

023

in which at least a beta-amino acid is involved [6]

027

in which at least a gamma-amino acid is involved, e.g. statine [6]

in which at least a delta-amino acid is involved, e.g. isosteres [6]

033

in which at least an epsilon- or zeta-amino acid is involved [6]

037

the abnormal link being formed by the side chain of an alpha-amino acid, e.g. gamma-Glu, epsilon-Lys, glutathione [6]

containing only normal peptide links [4]

Dipeptides [4]

062

the side chain of the first amino acid being acyclic, e.g. Gly, Ala [6]

065

the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr [6]

068

the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg [6]

072

the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn [6]

075

Asp-Phe; Derivatives thereof, e.g. aspartame [6]

078

the first amino acid being heterocyclic, e.g. Pro, His, Trp [6]

Tripeptides [4]

083

the side chain of the first amino acid being acyclic, e.g. Gly, Ala [6]

087

the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr [6]

the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg [6]

093

the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn [6]

097

the first amino acid being heterocyclic, e.g. Pro, His, Trp, e.g. thyroliberin, melanostatin [6]

Tetrapeptides [4]

103

the side chain of the first amino acid being acyclic, e.g. Gly, Ala [6]

107

the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr [6]

the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg [6]

113

the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn [6]

117

the first amino acid being heterocyclic, e.g. Pro, His, Trp [6]

Cyclic peptides [4]

Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof [4,6]

Linear peptides containing at least one abnormal peptide link [4]

Linear peptides containing only normal peptide links [4]

having 5 to 11 amino acids [4]

having 12 to 20 amino acids (gastrins C07K 14/595; somatostatins C07K 14/655; melanotropins C07K 14/68) [4,6]

Angiotensins; Related peptides [4]

Oxytocins; Vasopressins; Related peptides [4]

Kallidins; Bradykinins; Related peptides [4]

Eledoisins; Related peptides [4]

Luteinising hormone-releasing hormone (LHRH); Related peptides [6]

Gramicidins A, B, D; Related peptides [4]

Cyclic peptides containing at least one abnormal peptide link [4]

with only normal peptide links in the ring [4]

with at least one abnormal peptide link in the ring [4]

the cyclisation not occurring through 2,4-diamino-butanoic acid [4]

Bacitracins; Related peptides [4]

the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid [4]

Polymyxins; Related peptides [4]

Cyclic peptides containing only normal peptide links [4]

Gramicidins S, C; Tyrocidins A, B, C; Related peptides [4]

Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof [4,6]

C07K 11/00 - C07K 123:00